LTC4


SMILES CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N
InChIKey GWNVDXQDILPJIG-NXOLIXFESA-N

Chemical properties

Hydrogen bond acceptors 8
Hydrogen bond donors 7
Rotatable bonds 25
Molecular weight (Da) 625.3

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug Yes

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CysLT1 CLTR1 Human Leukotriene A pKi 7.0 7.55 8.1 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CysLT1 CLTR1 Human Leukotriene A pEC50 7.4 7.62 7.7 Guide to Pharmacology
CysLT1 CLTR1 Human Leukotriene A pIC50 6.44 6.45 6.46 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pEC50 7.03 7.5 8.64 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pIC50 8.4 8.44 8.48 Guide to Pharmacology
GPR17 GPR17 Human A orphans A pEC50 7.83 8.66 9.48 Guide to Pharmacology
GPR17 GPR17 Mouse A orphans A pEC50 9.13 9.13 9.13 Guide to Pharmacology
CysLT2 CLTR2 Human Leukotriene A pEC50 8.05 8.05 8.05 ChEMBL
CysLT1 CLTR1 Human Leukotriene A pEC50 7.37 7.37 7.37 ChEMBL