GPCRdb

chlorprothixene

Agent/drug
Bioactivity

chlorprothixene

SMILES	CN(C)CC/C=C1/c2ccccc2Sc2ccc(Cl)cc21
InChIKey	WSPOMRSOLSGNFJ-AUWJEWJLSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	3
Molecular weight (Da)	315.1

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.86	6.86	6.86	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	9.37	9.45	9.52	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	8.35	8.35	8.35	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.52	8.52	8.52	ChEMBL
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	8.50	8.51	8.52	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.52	8.52	8.52	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.07	8.07	8.07	Drug Central
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	8.25	8.25	8.25	ChEMBL
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	8.25	8.28	8.30	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.25	8.25	8.25	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	8.08	8.08	8.08	Drug Central
D₁	DRD1	Human	Dopamine	A	pKi	7.75	7.75	7.75	ChEMBL
D₁	DRD1	Bovine	Dopamine	A	pKi	6.60	6.60	6.60	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	7.74	7.74	7.74	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	8.11	8.11	8.11	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	8.53	8.53	8.53	Guide to Pharmacology
D₂	DRD2	Human	Dopamine	A	pKi	8.53	8.53	8.53	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.10	8.37	8.53	PDSP Ki database

Showing 1 to 20 of 47 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₁	HRH1	Human	Histamine	A	pIC50	6.06	7.53	9.00	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.05	8.05	8.05	Drug Central
H₁	HRH1	Rat	Histamine	A	pIC50	8.97	8.97	8.97	ChEMBL

Showing 1 to 3 of 3 entries

chlorprothixene

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 0

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.609	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.620	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.605	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.589	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.614	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.660	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.615	4	Yes
DRD2	D₂ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.732	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N05A	0.597	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia or other primary psychotic disorders, unspecified	6A2Z	N05A	0.591	4	Yes
DRD3	D₃ receptor	Dopamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N05A	0.704	4	Yes

Showing 1 to 12 of 12 entries

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chlorprothixene

chlorprothixene

Chemical Properties

Database connections

Bioactivities

chlorprothixene

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information