GPCRdb

BETAHISTINE

Agent/drug
Bioactivity

BETAHISTINE

SMILES	CNCCc1ccccn1
InChIKey	UUQMNUMQCIQDMZ-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	136.1

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Bioactivities

Affinity
Potency

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₃	HRH3	Rat	Histamine	A	pKi	5.69	5.69	5.69	ChEMBL
H₃	HRH3	Rat	Histamine	A	pKi	8.24	8.24	8.24	Drug Central

Showing 1 to 2 of 2 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

H₃	HRH3	Human	Histamine	A	pEC50	8.02	8.02	8.02	Drug Central
TA₁	TAAR1	Human	Trace amine	A	pIC50	5.22	5.22	5.22	ChEMBL
TA₁	TAAR1	Human	Trace amine	A	pEC50	5.91	5.91	5.91	ChEMBL

Showing 1 to 3 of 3 entries

BETAHISTINE

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Distribution across phases (no. indications)

Phase I 2

Phase II 4

Phase III 0

Phase IV 4

Database connections

ChEMBL_compound_ids ChEMBL_compound_ids PubChem DrugBank PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease

Gene	Protein	Receptor family	Ligand type	Class	Name	Phase	ICD11	ATC	Association score

HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Attention deficit hyperactivity disorder, presentation unspecified	1	6A05.Z		0.037
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Excessive weight gain	2	MG43.6		0.037
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Meniere disease	4	AB31.0		0.439
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	2	6A70.3		0.084
HRH1	H₁ receptor	Histamine receptors	Aminergic receptors	A	Vertigo, unspecified	4	MB48.0Z		0.577
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	A	Attention deficit hyperactivity disorder, presentation unspecified	1	6A05.Z		0.114
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	A	Excessive weight gain	2	MG43.6		0.037
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	A	Meniere disease	4	AB31.0		0.438
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	A	Single episode depressive disorder, severe, without psychotic symptoms	2	6A70.3		0.074
HRH3	H₃ receptor	Histamine receptors	Aminergic receptors	A	Vertigo, unspecified	4	MB48.0Z		0.370

Showing 1 to 10 of 10 entries