GPCRdb

clomipramine

Agent/drug
Bioactivity

clomipramine

SMILES	CN(C)CCCN1c2ccccc2CCc2ccc(Cl)cc21
InChIKey	GDLIGKIOYRNHDA-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	2
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	314.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.10	8.10	8.10	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.40	7.40	7.40	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	7.14	7.14	7.14	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.15	8.15	8.15	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.06	7.06	7.06	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.49	8.49	8.49	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.28	6.28	6.28	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.28	6.28	6.28	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	7.34	7.34	7.34	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	6.69	6.69	6.69	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	5.00	5.00	5.00	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.72	7.72	7.72	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	7.45	7.45	7.45	PDSP Ki database

Showing 1 to 20 of 56 entries

Search:

Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.00	8.70	10.40	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	7.98	7.98	7.98	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	6.88	6.88	6.88	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	6.75	6.75	6.75	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	5.85	5.85	5.85	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.00	7.00	7.00	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	5.85	5.85	5.85	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	7.17	7.17	7.17	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	6.62	6.62	6.62	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.47	7.47	7.47	ChEMBL
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pIC50	6.61	6.61	6.61	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	5.95	5.95	5.95	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	6.38	6.38	6.38	ChEMBL
D₃	DRD3	Human	Dopamine	A	pIC50	6.86	6.86	6.86	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	9.70	9.70	9.70	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	7.07	7.07	7.07	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.01	8.01	8.01	Drug Central
H₂	HRH2	Human	Histamine	A	pIC50	5.69	5.69	5.69	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	5.85	6.42	7.00	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pIC50	7.04	7.04	7.04	ChEMBL

Showing 1 to 20 of 26 entries

clomipramine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 0

Phase III 9

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central PubChem GPCRdb

Sankey plot

Drug Information

Search:

Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3	N06A	0.575	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Dementia, unknown or unspecified cause	6D8Z	N06A	0.575	3	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.607	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z	N06A	0.561	4	Yes
5HT2A	5-HT_2A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N06A	0.620	3	Yes
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3	N06A	0.262	3	Yes
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Dementia, unknown or unspecified cause	6D8Z	N06A	0.259	3	Yes
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.448	4	Yes
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z	N06A	0.038	4	Yes
5HT2B	5-HT_2B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N06A	0.591	3	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Anxiety	MB24.3	N06A	0.557	3	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Dementia, unknown or unspecified cause	6D8Z	N06A	0.566	3	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.604	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Obsessive-compulsive disorder, unspecified	6B20.Z	N06A	0.539	4	Yes
5HT2C	5-HT_2C receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Schizophrenia, episode unspecified	6A20.Z	N06A	0.614	3	Yes

Showing 1 to 15 of 15 entries

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clomipramine

clomipramine

Chemical Properties

Database connections

Bioactivities

clomipramine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information