APROFENE


SMILES CCN(CC)CCOC(=O)C(C)(c1ccccc1)c1ccccc1
InChIKey DIDYGLSKVUKRRP-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 8
Molecular weight (Da) 325.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.77 8.77 8.77 ChEMBL
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 6.2 7.17 8.13 ChEMBL
M3 ACM3 Human Acetylcholine (muscarinic) A pKi 5.11 6.61 8.11 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKi 6.97 7.5 8.03 ChEMBL
M2 ACM2 Human Acetylcholine (muscarinic) A pKd 8.5 8.5 8.5 ChEMBL
M1 ACM1 Human Acetylcholine (muscarinic) A pKi 7.58 8.03 8.68 ChEMBL
M3 ACM3 Rat Acetylcholine (muscarinic) A pKi 8.47 8.47 8.47 PDSP Ki database
M2 ACM2 Rat Acetylcholine (muscarinic) A pKi 8.31 8.31 8.31 PDSP Ki database
M1 ACM1 Rat Acetylcholine (muscarinic) A pKi 9.07 9.07 9.07 PDSP Ki database
M4 ACM4 Human Acetylcholine (muscarinic) A pKi 8.42 8.42 8.42 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database