TETRAHYDROCANNABIVARIN


SMILES CCCc1cc(O)c2c(c1)OC(C)(C)[C@@H]1CCC(C)=C[C@@H]21
InChIKey ZROLHBHDLIHEMS-HUUCEWRRSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 2
Molecular weight (Da) 286.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB1 CNR1 Mouse Cannabinoid A pKi 7.12 7.12 7.12 ChEMBL
CB2 CNR2 Human Cannabinoid A pKi 7.2 7.65 8.55 ChEMBL
CB1 CNR1 Human Cannabinoid A pKi 6.0 7.31 8.82 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
CB1 CNR1 Mouse Cannabinoid A pEC50 4.9 4.9 4.9 ChEMBL
GPR55 GPR55 Human GPR18, GPR55 and GPR119 A pEC50 6.06 6.06 6.06 ChEMBL
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pEC50 8.27 8.27 8.27 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pEC50 7.55 7.55 7.55 ChEMBL
CB2 CNR2 Human Cannabinoid A pEC50 7.01 7.21 7.42 ChEMBL
CB2 CNR2 Human Cannabinoid A pIC50 7.75 7.75 7.75 ChEMBL
CB1 CNR1 Human Cannabinoid A pIC50 7.88 7.88 7.88 ChEMBL