PF-04852946


SMILES COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O
InChIKey MDVYCLAYSVNYDS-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 456.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP1 PD2R Human Prostanoid A pKi 5.92 5.92 5.92 ChEMBL
EP2 PE2R2 Human Prostanoid A pKi 9.2 9.2 9.2 ChEMBL
EP4 PE2R4 Human Prostanoid A pKi 4.79 4.79 4.79 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP2 PE2R2 Human Prostanoid A pKB 8.45 8.49 8.53 Guide to Pharmacology