Compound 24 [Pmid: 16451050]


SMILES O=C([C@H]1CCCN1Cc1ccccc1)NCCCN1CCC2(CC1)OCc1c2cccc1
InChIKey MAKMQGKJURAJEN-RUZDIDTESA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 433.3

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 4EA3

Bioactivity

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
NOP OPRX Human Opioid A pKi 9.62 9.62 9.62 Guide to Pharmacology
NOP OPRX Human Opioid A pIC50 9.57 9.78 10.0 Guide to Pharmacology
NOP OPRX Mouse Opioid A pKd 8.24 8.24 8.24 ChEMBL
NOP OPRX Human Opioid A pIC50 9.57 9.7 9.82 ChEMBL
NOP OPRX Human Opioid A pKi 9.62 9.62 9.62 ChEMBL
κ OPRK Human Opioid A pIC50 5.6 5.6 5.6 ChEMBL
μ OPRM Human Opioid A pIC50 5.17 5.17 5.17 ChEMBL