PGF


SMILES CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O
InChIKey PXGPLTODNUVGFL-YNNPMVKQSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 12
Molecular weight (Da) 354.2

Drug properties

Molecular type Small molecule
Physiological/Surrogate Endogenous
Approved drug Yes

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
DP1 PD2R Human Prostanoid A pKi 6.1 6.25 6.4 Guide to Pharmacology
DP2 PD2R2 Human Prostanoid A pKi 6.4 6.4 6.4 Guide to Pharmacology
EP1 PE2R1 Human Prostanoid A pKi 6.2 6.25 6.3 Guide to Pharmacology
EP2 PE2R2 Human Prostanoid A pKi 5.2 5.6 6.0 Guide to Pharmacology
EP3 PE2R3 Human Prostanoid A pKi 7.42 7.42 7.42 Guide to Pharmacology
EP4 PE2R4 Human Prostanoid A pKi 9.1 9.29 9.49 Guide to Pharmacology
FP PF2R Human Prostanoid A pKi 7.9 8.2 8.5 Guide to Pharmacology
TP TA2R Human Prostanoid A pKi 5.1 5.1 5.1 Guide to Pharmacology
EP1 PE2R1 Mouse Prostanoid A pKi 5.9 5.9 5.9 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pKi 6.67 6.67 6.67 Guide to Pharmacology
EP3 PE2R3 Mouse Prostanoid A pKi 7.12 7.12 7.12 Guide to Pharmacology
EP1 PE2R1 Rat Prostanoid A pKi 6.4 6.4 6.4 Guide to Pharmacology
FP PF2R Mouse Prostanoid A pKi 8.5 8.5 8.5 Guide to Pharmacology
DP2 PD2R2 Mouse Prostanoid A pKi 6.2 6.2 6.2 Guide to Pharmacology
EP2 PE2R2 Rat Prostanoid A pKi 5.6 5.6 5.6 Guide to Pharmacology
EP4 PE2R4 Rat Prostanoid A pKi 6.2 6.2 6.2 Guide to Pharmacology
FP PF2R Bovine Prostanoid A pKi 6.89 6.89 6.89 ChEMBL
FP PF2R Human Prostanoid A pKi 6.92 6.92 6.92 ChEMBL
EP1 PE2R1 Mouse Prostanoid A pKi 5.89 5.89 5.89 PDSP Ki database
EP3 PE2R3 Mouse Prostanoid A pKi 7.12 7.12 7.12 PDSP Ki database
FP PF2R Mouse Prostanoid A pKi 8.47 8.47 8.47 PDSP Ki database
EP3 PE2R3 Bovine Prostanoid A pKi 7.43 7.53 7.62 PDSP Ki database
FP PF2R Bovine Prostanoid A pKi 6.92 6.92 6.92 PDSP Ki database
FP PF2R Human Prostanoid A pKi 7.32 7.91 8.49 PDSP Ki database
EP1 PE2R1 Human Prostanoid A pKi 6.26 6.26 6.26 PDSP Ki database
EP3 PE2R3 Human Prostanoid A pKi 7.42 7.42 7.42 PDSP Ki database
EP4 PE2R4 Human Prostanoid A pKi 6.02 6.28 6.54 PDSP Ki database
DP1 PD2R Human Prostanoid A pKi 6.06 6.06 6.06 PDSP Ki database
IP PI2R Human Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
TP TA2R Mouse Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
IP PI2R Mouse Prostanoid A pKi 5.0 5.0 5.0 PDSP Ki database
DP2 PD2R2 Human Prostanoid A pKi 8.19 8.19 8.19 Drug Central
EP2 PE2R2 Human Prostanoid A pKi 8.22 8.22 8.22 Drug Central
FP PF2R Human Prostanoid A pKd 8.08 8.08 8.08 Drug Central
TP TA2R Human Prostanoid A pKi 8.29 8.29 8.29 Drug Central
EP1 PE2R1 Mouse Prostanoid A pKi 8.23 8.23 8.23 Drug Central
EP3 PE2R3 Mouse Prostanoid A pKi 8.15 8.15 8.15 Drug Central
EP1 PE2R1 Rat Prostanoid A pKi 8.19 8.19 8.19 Drug Central
FP PF2R Bovine Prostanoid A pKi 8.16 8.16 8.16 Drug Central
DP2 PD2R2 Mouse Prostanoid A pKi 8.21 8.21 8.21 Drug Central
EP2 PE2R2 Rat Prostanoid A pKi 8.25 8.25 8.25 Drug Central
EP4 PE2R4 Rat Prostanoid A pKi 8.21 8.21 8.21 Drug Central
DP1 PD2R Rat Prostanoid A pKi 6.16 6.16 6.16 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
EP4 PE2R4 Human Prostanoid A pEC50 6.05 6.05 6.05 Guide to Pharmacology
EP3 PE2R3 Rat Prostanoid A pEC50 8.38 8.38 8.38 Guide to Pharmacology
FP PF2R Bovine Prostanoid A pIC50 6.85 6.85 6.85 ChEMBL
FP PF2R Mouse Prostanoid A pEC50 7.61 7.76 7.9 ChEMBL
FP PF2R Human Prostanoid A pEC50 7.1 7.36 7.61 ChEMBL
FP PF2R Human Prostanoid A pIC50 7.37 8.16 8.6 ChEMBL
EP1 PE2R1 Human Prostanoid A pIC50 6.42 6.54 6.66 ChEMBL
EP1 PE2R1 Human Prostanoid A pEC50 6.22 6.22 6.22 ChEMBL
EP3 PE2R3 Human Prostanoid A pIC50 6.49 6.72 6.96 ChEMBL
EP3 PE2R3 Human Prostanoid A pEC50 5.64 5.64 5.64 ChEMBL
TP TA2R Human Prostanoid A pEC50 5.85 5.85 5.85 ChEMBL
DP1 PD2R Human Prostanoid A pIC50 8.27 8.27 8.27 Drug Central
EP1 PE2R1 Human Prostanoid A pIC50 8.18 8.18 8.18 Drug Central
EP4 PE2R4 Human Prostanoid A pIC50 8.27 8.27 8.27 Drug Central
EP3 PE2R3 Rat Prostanoid A pEC50 8.08 8.08 8.08 Drug Central
FP PF2R Mouse Prostanoid A pEC50 8.1 8.1 8.1 Drug Central
DP1 PD2R Human Prostanoid A pIC50 5.35 5.35 5.35 ChEMBL
EP3 PE2R3 Human Prostanoid A pIC50 8.16 8.16 8.16 Drug Central
EP4 PE2R4 Human Prostanoid A pIC50 5.38 5.38 5.38 ChEMBL