psilocin


SMILES CN(CCc1c[nH]c2c1c(O)ccc2)C
InChIKey SPCIYGNTAMCTRO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 204.1

Drug properties

Molecular type Small molecule
Physiological/Surrogate Surrogate
Approved drug No

Database connections

Structure pdb 8DPG 7WC5
Ligand site mutations 5-HT2A 5-HT2C

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Bovine 5-Hydroxytryptamine A pKi 6.43 6.43 6.43 PDSP Ki database
5-HT2B F6QI78 Bovine 5-Hydroxytryptamine A pKi 6.35 6.35 6.35 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.31 7.31 7.31 PDSP Ki database
5-HT2A 5HT2A Rat 5-Hydroxytryptamine A pKi 7.6 7.76 7.92 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.0 8.0 8.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Mouse 5-Hydroxytryptamine A pEC50 8.0 8.0 8.01 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pEC50 7.24 7.24 7.24 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pIC50 8.97 8.97 8.97 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pEC50 7.52 7.52 7.52 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pIC50 8.11 8.11 8.11 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 7.12 7.86 8.37 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 8.08 8.08 8.08 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pEC50 7.62 7.62 7.62 Guide to Pharmacology