Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
AssayType |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 11120893 | 11294 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL102250 | 11294 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 | 10.1021/jm030020m | ||
| 10925382 | 11788 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL105091 | 11788 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 | 10.1021/jm030020m | ||
| 11759467 | 11941 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL105958 | 11941 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 | 10.1021/jm030020m | ||
| 10308815 | 130256 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 341 | 4 | 1 | 4 | 3.0 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 | 10.1016/j.bmcl.2015.07.042 | ||
| CHEMBL3617557 | 130256 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 341 | 4 | 1 | 4 | 3.0 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 | 10.1016/j.bmcl.2015.07.042 | ||
| 11044798 | 11940 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 300 | 4 | 2 | 3 | 3.1 | CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | ||
| CHEMBL105955 | 11940 | 0 | None | - | 1 | Human | 7.9 | pEC50 | = | 7.9 | Functional | ChEMBL | 300 | 4 | 2 | 3 | 3.1 | CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | ||
| 11372635 | 73861 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | ||
| CHEMBL187308 | 73861 | 0 | None | - | 1 | Human | 6.9 | pEC50 | = | 6.9 | Functional | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | ||
| 11056946 | 115670 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL321080 | 115670 | 0 | None | - | 1 | Human | 7.8 | pEC50 | = | 7.8 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 | 10.1021/jm030020m | ||
| 10946905 | 170461 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 3 | 2 | 3 | 3.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL420475 | 170461 | 0 | None | - | 1 | Human | 7.7 | pEC50 | = | 7.7 | Functional | ChEMBL | 312 | 3 | 2 | 3 | 3.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 | 10.1021/jm030020m | ||
| 11110452 | 11902 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL105722 | 11902 | 0 | None | - | 1 | Human | 7.6 | pEC50 | = | 7.6 | Functional | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 | 10.1021/jm030020m | ||
| 44387174 | 68547 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | ||
| CHEMBL177238 | 68547 | 0 | None | - | 1 | Human | 6.6 | pEC50 | = | 6.6 | Functional | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | ||
| 9947817 | 11819 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | ||
| CHEMBL105261 | 11819 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | ||
| 11011968 | 11713 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 298 | 3 | 2 | 3 | 2.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL104720 | 11713 | 0 | None | - | 1 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 298 | 3 | 2 | 3 | 2.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 | 10.1021/jm030020m | ||
| 2543 | 10479 | 68 | None | -3 | 14 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | ||
| 5358 | 10479 | 68 | None | -3 | 14 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | ||
| 54 | 10479 | 68 | None | -3 | 14 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | ||
| CHEMBL128 | 10479 | 68 | None | -3 | 14 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | ||
| DB00669 | 10479 | 68 | None | -3 | 14 | Human | 7.5 | pEC50 | = | 7.5 | Functional | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | ||
| 10445946 | 174642 | 4 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | ||
| CHEMBL431041 | 174642 | 4 | None | - | 1 | Human | 7.4 | pEC50 | = | 7.4 | Functional | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | ||
| 44395894 | 73722 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 371 | 3 | 1 | 4 | 4.2 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | ||
| CHEMBL186662 | 73722 | 0 | None | - | 1 | Human | 6.3 | pEC50 | = | 6.3 | Functional | ChEMBL | 371 | 3 | 1 | 4 | 4.2 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | ||
| 44395925 | 73921 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 390 | 3 | 2 | 4 | 3.6 | CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | ||
| CHEMBL187581 | 73921 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 390 | 3 | 2 | 4 | 3.6 | CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | ||
| 122190350 | 130249 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1 | 10.1016/j.bmcl.2015.07.042 | ||
| CHEMBL3617550 | 130249 | 0 | None | - | 1 | Human | 7.3 | pEC50 | = | 7.3 | Functional | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1 | 10.1016/j.bmcl.2015.07.042 | ||
| 44352308 | 124265 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | ||
| CHEMBL339980 | 124265 | 0 | None | - | 1 | Human | 8.2 | pEC50 | = | 8.2 | Functional | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | ||
| 44395930 | 73783 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 388 | 3 | 2 | 4 | 4.0 | CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | ||
| CHEMBL186951 | 73783 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 388 | 3 | 2 | 4 | 4.0 | CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | ||
| 9863365 | 68549 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 353 | 3 | 1 | 4 | 4.0 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | ||
| CHEMBL177258 | 68549 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 353 | 3 | 1 | 4 | 4.0 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | ||
| 44386896 | 139063 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | ||
| CHEMBL369705 | 139063 | 0 | None | - | 1 | Human | 7.2 | pEC50 | = | 7.2 | Functional | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | ||
| 5 | 6927 | 72 | None | -15 | 27 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm0155190 | ||
| 5202 | 6927 | 72 | None | -15 | 27 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm0155190 | ||
| CHEMBL39 | 6927 | 72 | None | -15 | 27 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm0155190 | ||
| DB08839 | 6927 | 72 | None | -15 | 27 | Human | 8.1 | pEC50 | = | 8.1 | Functional | ChEMBL | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 10.1021/jm0155190 | ||
| 9798021 | 130248 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 340 | 4 | 1 | 3 | 3.6 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | ||
| CHEMBL3617549 | 130248 | 0 | None | - | 1 | Human | 7.1 | pEC50 | = | 7.1 | Functional | ChEMBL | 340 | 4 | 1 | 3 | 3.6 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | ||
| 11046087 | 11719 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 | 10.1021/jm030020m | ||
| CHEMBL104753 | 11719 | 0 | None | - | 1 | Human | 8.0 | pEC50 | = | 8.0 | Functional | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 | 10.1021/jm030020m | ||
| 10000386 | 66893 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 389 | 3 | 1 | 4 | 4.3 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | ||
| CHEMBL173949 | 66893 | 0 | None | - | 1 | Human | 7.0 | pEC50 | = | 7.0 | Functional | ChEMBL | 389 | 3 | 1 | 4 | 4.3 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | ||
| 146420200 | 191660 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 360 | 3 | 1 | 4 | 3.8 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cn3)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4852743 | 191660 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 360 | 3 | 1 | 4 | 3.8 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cn3)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| 146420010 | 193113 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 393 | 4 | 1 | 3 | 4.5 | CCN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4874958 | 193113 | 0 | None | - | 1 | Human | 6.8 | pIC50 | = | 6.8 | Functional | ChEMBL | 393 | 4 | 1 | 3 | 4.5 | CCN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| 146420029 | 191541 | 0 | None | 60 | 6 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 379 | 3 | 1 | 3 | 4.2 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4851044 | 191541 | 0 | None | 60 | 6 | Human | 7.7 | pIC50 | = | 7.7 | Functional | ChEMBL | 379 | 3 | 1 | 3 | 4.2 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| 146420204 | 192498 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 377 | 3 | 1 | 3 | 4.5 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4865700 | 192498 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 377 | 3 | 1 | 3 | 4.5 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| 146420207 | 192161 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 344 | 3 | 1 | 4 | 3.3 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cn3)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4860576 | 192161 | 0 | None | - | 1 | Human | 7.6 | pIC50 | = | 7.6 | Functional | ChEMBL | 344 | 3 | 1 | 4 | 3.3 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cn3)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| 146420206 | 192289 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 359 | 3 | 1 | 3 | 4.4 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cc3)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4862526 | 192289 | 0 | None | - | 1 | Human | 7.5 | pIC50 | = | 7.5 | Functional | ChEMBL | 359 | 3 | 1 | 3 | 4.4 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(Cl)cc3)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| 146420182 | 191297 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 361 | 3 | 1 | 3 | 4.0 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4847626 | 191297 | 0 | None | - | 1 | Human | 8.3 | pIC50 | = | 8.3 | Functional | ChEMBL | 361 | 3 | 1 | 3 | 4.0 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| 146420009 | 192948 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 405 | 4 | 1 | 3 | 4.7 | O=C(Nc1cccc(C(F)=C2CCN(C3CC3)CC2)n1)c1c(F)cc(F)cc1F | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4872571 | 192948 | 0 | None | - | 1 | Human | 6.2 | pIC50 | = | 6.2 | Functional | ChEMBL | 405 | 4 | 1 | 3 | 4.7 | O=C(Nc1cccc(C(F)=C2CCN(C3CC3)CC2)n1)c1c(F)cc(F)cc1F | 10.1016/j.ejmech.2021.113782 | ||
| 146420181 | 191244 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 343 | 3 | 1 | 3 | 3.9 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4846825 | 191244 | 0 | None | - | 1 | Human | 8.2 | pIC50 | = | 8.2 | Functional | ChEMBL | 343 | 3 | 1 | 3 | 3.9 | CN1CCC(=C(F)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 | 10.1016/j.ejmech.2021.113782 | ||
| 164620307 | 192850 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 415 | 4 | 1 | 3 | 4.8 | O=C(Nc1cccc(C(F)=C2CCN(C(F)F)CC2)n1)c1c(F)cc(F)cc1F | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL4871295 | 192850 | 0 | None | - | 1 | Human | 6.1 | pIC50 | = | 6.1 | Functional | ChEMBL | 415 | 4 | 1 | 3 | 4.8 | O=C(Nc1cccc(C(F)=C2CCN(C(F)F)CC2)n1)c1c(F)cc(F)cc1F | 10.1016/j.ejmech.2021.113782 | ||
| 11610526 | 9062 | 64 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1016/j.ejmech.2021.113782 | ||
| 3928 | 9062 | 64 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1016/j.ejmech.2021.113782 | ||
| 5351 | 9062 | 64 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1016/j.ejmech.2021.113782 | ||
| CHEMBL3039520 | 9062 | 64 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1016/j.ejmech.2021.113782 | ||
| DB11732 | 9062 | 64 | None | - | 1 | Human | 7.1 | pIC50 | = | 7.1 | Functional | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1016/j.ejmech.2021.113782 | ||
| 102 | 10899 | 48 | None | -8 | 20 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | ||
| 3659 | 10899 | 48 | None | -8 | 20 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | ||
| 8969 | 10899 | 48 | None | -8 | 20 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | ||
| CHEMBL15245 | 10899 | 48 | None | -8 | 20 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | ||
| DB01392 | 10899 | 48 | None | -8 | 20 | Rat | 8.2 | pIC50 | = | 8.2 | Functional | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | ||
| 11954224 | 222732 | 0 | None | -1 | 5 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | ||
| 134 | 9292 | 24 | None | -5 | 18 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 1775 | 9292 | 24 | None | -5 | 18 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 9681 | 9292 | 24 | None | -5 | 18 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| CHEMBL1065 | 9292 | 24 | None | -5 | 18 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| DB00247 | 9292 | 24 | None | -5 | 18 | Rat | 8.1 | pIC50 | = | 8.1 | Functional | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | ||
| 2543 | 10479 | 68 | None | -3 | 14 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8384716 | ||
| 5358 | 10479 | 68 | None | -3 | 14 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8384716 | ||
| 54 | 10479 | 68 | None | -3 | 14 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8384716 | ||
| CHEMBL128 | 10479 | 68 | None | -3 | 14 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8384716 | ||
| DB00669 | 10479 | 68 | None | -3 | 14 | Human | 7.2 | pIC50 | = | 7.2 | Functional | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8384716 | ||
| 1809 | 6922 | 32 | None | -8511 | 8 | Rat | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8384716 | ||
| 4 | 6922 | 32 | None | -8511 | 8 | Rat | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8384716 | ||
| CHEMBL18840 | 6922 | 32 | None | -8511 | 8 | Rat | 5.6 | pIC50 | None | 5.6 | Functional | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8384716 | ||
| 102 | 10899 | 48 | None | -8 | 20 | Rat | 6.2 | pIC50 | None | 6.2 | Functional | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8384716 | ||
| 3659 | 10899 | 48 | None | -8 | 20 | Rat | 6.2 | pIC50 | None | 6.2 | Functional | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8384716 | ||
| 8969 | 10899 | 48 | None | -8 | 20 | Rat | 6.2 | pIC50 | None | 6.2 | Functional | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8384716 | ||
| CHEMBL15245 | 10899 | 48 | None | -8 | 20 | Rat | 6.2 | pIC50 | None | 6.2 | Functional | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8384716 | ||
| DB01392 | 10899 | 48 | None | -8 | 20 | Rat | 6.2 | pIC50 | None | 6.2 | Functional | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8384716 | ||
| 133 | 9274 | 52 | None | -1258 | 28 | Rat | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8384716 | ||
| 1723 | 9274 | 52 | None | -1258 | 28 | Rat | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8384716 | ||
| 28693 | 9274 | 52 | None | -1258 | 28 | Rat | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8384716 | ||
| CHEMBL19215 | 9274 | 52 | None | -1258 | 28 | Rat | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8384716 | ||
| DB13520 | 9274 | 52 | None | -1258 | 28 | Rat | 6.3 | pIC50 | None | 6.3 | Functional | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8384716 | ||
| 5 | 6927 | 72 | None | -120 | 27 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8384716 | ||
| 5202 | 6927 | 72 | None | -120 | 27 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8384716 | ||
| CHEMBL39 | 6927 | 72 | None | -120 | 27 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8384716 | ||
| DB08839 | 6927 | 72 | None | -120 | 27 | Rat | 7.2 | pIC50 | None | 7.2 | Functional | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8384716 | ||
| 1043 | 8363 | 14 | None | -251 | 23 | Rat | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8384716 | ||
| 149 | 8363 | 14 | None | -251 | 23 | Rat | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8384716 | ||
| 8223 | 8363 | 14 | None | -251 | 23 | Rat | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8384716 | ||
| CHEMBL442 | 8363 | 14 | None | -251 | 23 | Rat | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8384716 | ||
| DB00696 | 8363 | 14 | None | -251 | 23 | Rat | 7.3 | pIC50 | None | 7.3 | Functional | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8384716 | ||
| 134 | 9292 | 24 | None | -5 | 18 | Rat | 7.8 | pIC50 | None | 7.8 | Functional | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8384716 | ||
| 1775 | 9292 | 24 | None | -5 | 18 | Rat | 7.8 | pIC50 | None | 7.8 | Functional | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8384716 | ||
| 9681 | 9292 | 24 | None | -5 | 18 | Rat | 7.8 | pIC50 | None | 7.8 | Functional | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8384716 | ||
| CHEMBL1065 | 9292 | 24 | None | -5 | 18 | Rat | 7.8 | pIC50 | None | 7.8 | Functional | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8384716 | ||
| DB00247 | 9292 | 24 | None | -5 | 18 | Rat | 7.8 | pIC50 | None | 7.8 | Functional | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8384716 | ||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Assay information | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Similar- ity |
Common name |
GPCRdb ID |
#Vendors |
Reference ligand |
Fold selectivity |
# Tested GPCRs |
Species |
p-value (-log) |
Activity Type |
Activity Relation |
Activity Value |
Assay Type |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
| 146420029 | 191541 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 379 | 3 | 1 | 3 | 4.2 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | |||
| CHEMBL4851044 | 191541 | 0 | None | - | 0 | Human | 9.5 | pIC50 | = | 9.5 | Binding | ChEMBL | 379 | 3 | 1 | 3 | 4.2 | CN1CCC(=C(F)c2cccc(NC(=O)c3c(F)cc(F)cc3F)n2)CC1 | 10.1016/j.ejmech.2021.113782 | |||
| 18366015 | 85147 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| CHEMBL2110300 | 85147 | 0 | None | - | 0 | Human | 6.4 | pIC50 | = | 6.4 | Binding | ChEMBL | 313 | 4 | 2 | 3 | 2.6 | CN(C)[C@H]1C[C@H](c2c[nH]c3ccc(CC4COC(=O)N4)cc32)C1 | 10.1021/jm000956k | |||
| 114 | 9034 | 14 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| 6426760 | 9034 | 14 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| CHEMBL292779 | 9034 | 14 | None | - | 1 | Human | 5.4 | pIC50 | = | 5.4 | Binding | ChEMBL | 432 | 8 | 1 | 5 | 3.7 | Fc1cccc(c1)CCN1CCN(CC1)CCCc1c[nH]c2c1cc(cc2)n1cnnc1 | 10.1021/jm9704560 | |||
| 151 | 9194 | 44 | None | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm7011722 | |||
| 20 | 9194 | 44 | None | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm7011722 | |||
| 5311258 | 9194 | 44 | None | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm7011722 | |||
| CHEMBL101690 | 9194 | 44 | None | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm7011722 | |||
| 44352320 | 25716 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(c2c[nH]c3cccc(NC(=O)c4ccc(F)cc4)c23)CC1 | 10.1021/jm0155190 | |||
| CHEMBL128636 | 25716 | 0 | None | - | 1 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(c2c[nH]c3cccc(NC(=O)c4ccc(F)cc4)c23)CC1 | 10.1021/jm0155190 | |||
| 151 | 9194 | 44 | None | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2003.09.091 | |||
| 20 | 9194 | 44 | None | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2003.09.091 | |||
| 5311258 | 9194 | 44 | None | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2003.09.091 | |||
| CHEMBL101690 | 9194 | 44 | None | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2003.09.091 | |||
| 10220230 | 114199 | 2 | None | 4 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 230 | 1 | 2 | 3 | 2.0 | CN1CCC(c2c[nH]c3ccc(N)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL318105 | 114199 | 2 | None | 4 | 3 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 230 | 1 | 2 | 3 | 2.0 | CN1CCC(c2c[nH]c3ccc(N)nc23)CC1 | 10.1021/jm030020m | |||
| 10220244 | 114201 | 1 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 231 | 1 | 2 | 3 | 2.1 | CN1CCC(c2c[nH]c3ccc(O)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL318110 | 114201 | 1 | None | - | 1 | Human | 7.0 | pKi | = | 7 | Binding | ChEMBL | 231 | 1 | 2 | 3 | 2.1 | CN1CCC(c2c[nH]c3ccc(O)nc23)CC1 | 10.1021/jm030020m | |||
| 24865727 | 199892 | 0 | None | -630 | 11 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL522708 | 199892 | 0 | None | -630 | 11 | Human | 6.0 | pKi | = | 6 | Binding | ChEMBL | 479 | 7 | 0 | 5 | 4.4 | Cc1ccc2c(OCCN3CCC(Cc4cccc(N5CCCS5(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 11810310 | 11490 | 0 | None | 12 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103550 | 11490 | 0 | None | 12 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(F)c4)nc23)CC1 | 10.1021/jm030020m | |||
| 10970604 | 11835 | 0 | None | -3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 367 | 3 | 3 | 3 | 4.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105369 | 11835 | 0 | None | -3 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 367 | 3 | 3 | 3 | 4.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)Nc4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11727140 | 116170 | 0 | None | 58 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 326 | 3 | 2 | 3 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL321967 | 116170 | 0 | None | 58 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 326 | 3 | 2 | 3 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCC4)nc23)CC1 | 10.1021/jm030020m | |||
| 10915350 | 170185 | 0 | None | 9 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 359 | 3 | 2 | 4 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(C#N)c4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL419547 | 170185 | 0 | None | 9 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 359 | 3 | 2 | 4 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc(C#N)c4)nc23)CC1 | 10.1021/jm030020m | |||
| 122190357 | 130255 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 356 | 4 | 2 | 4 | 3.3 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2O)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617556 | 130255 | 0 | None | - | 1 | Human | 6.0 | pKi | = | 6.0 | Binding | ChEMBL | 356 | 4 | 2 | 4 | 3.3 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2O)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 44395894 | 73722 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 371 | 3 | 1 | 4 | 4.2 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL186662 | 73722 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 371 | 3 | 1 | 4 | 4.2 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4F)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 11035452 | 11776 | 0 | None | 8 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL105025 | 11776 | 0 | None | 8 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 11068036 | 170267 | 0 | None | 2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1ccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)cc1 | 10.1021/jm030020m | |||
| CHEMBL420101 | 170267 | 0 | None | 2 | 2 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1ccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)cc1 | 10.1021/jm030020m | |||
| 11223004 | 208993 | 0 | None | -4 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 389 | 5 | 3 | 3 | 3.9 | O=S(=O)(Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1Cl | 10.1021/jm049243i | |||
| CHEMBL609742 | 208993 | 0 | None | -4 | 5 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 389 | 5 | 3 | 3 | 3.9 | O=S(=O)(Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1)c1ccccc1Cl | 10.1021/jm049243i | |||
| 44395930 | 73783 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 3 | 2 | 4 | 4.0 | CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL186951 | 73783 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 388 | 3 | 2 | 4 | 4.0 | CN1CCC(N2CNc3ccc(NC(=O)c4ccc(F)cc4Cl)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 10991087 | 11310 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 6 | 2 | 3 | 3.9 | CCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL102344 | 11310 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 328 | 6 | 2 | 3 | 3.9 | CCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 10904295 | 11481 | 0 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103503 | 11481 | 0 | None | 1 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1021/jm030020m | |||
| 10925382 | 11788 | 0 | None | 43 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105091 | 11788 | 0 | None | 43 | 4 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccco4)nc23)CC1 | 10.1021/jm030020m | |||
| 10991464 | 138599 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 341 | 5 | 1 | 4 | 3.6 | Cc1oc2ccc(NC(=O)c3ccc(F)cc3)nc2c1CCN(C)C | 10.1016/j.bmcl.2003.09.091 | |||
| CHEMBL369391 | 138599 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 341 | 5 | 1 | 4 | 3.6 | Cc1oc2ccc(NC(=O)c3ccc(F)cc3)nc2c1CCN(C)C | 10.1016/j.bmcl.2003.09.091 | |||
| 122190351 | 130250 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2cc(NC(=O)c3ccc(F)cc3)ccc2F)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617551 | 130250 | 0 | None | - | 1 | Human | 5.9 | pKi | = | 5.9 | Binding | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2cc(NC(=O)c3ccc(F)cc3)ccc2F)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 11069268 | 11927 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 394 | 6 | 2 | 3 | 4.9 | CCCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105850 | 11927 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 394 | 6 | 2 | 3 | 4.9 | CCCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 10925076 | 115179 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 5 | 2 | 3 | 3.5 | CCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL319857 | 115179 | 0 | None | - | 1 | Human | 7.9 | pKi | = | 7.9 | Binding | ChEMBL | 314 | 5 | 2 | 3 | 3.5 | CCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 11068509 | 115712 | 0 | None | 6 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 364 | 4 | 2 | 4 | 3.6 | COc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 | 10.1021/jm030020m | |||
| CHEMBL321133 | 115712 | 0 | None | 6 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 364 | 4 | 2 | 4 | 3.6 | COc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 | 10.1021/jm030020m | |||
| 11200511 | 208509 | 0 | None | -15 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 | 10.1021/jm049243i | |||
| CHEMBL606547 | 208509 | 0 | None | -15 | 8 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccccc3Cl)cc12 | 10.1021/jm049243i | |||
| 44395925 | 73921 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 390 | 3 | 2 | 4 | 3.6 | CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL187581 | 73921 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 390 | 3 | 2 | 4 | 3.6 | CN1CCC(N2CNc3ccc(NC(=O)c4c(F)cc(F)cc4F)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 44395786 | 177785 | 0 | None | 9 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 353 | 3 | 1 | 4 | 4.0 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL445651 | 177785 | 0 | None | 9 | 2 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 353 | 3 | 1 | 4 | 4.0 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 71459954 | 85957 | 0 | None | -17 | 7 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 495 | 6 | 3 | 3 | 4.0 | O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 | 10.1021/jm049243i | |||
| CHEMBL2113386 | 85957 | 0 | None | -17 | 7 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 495 | 6 | 3 | 3 | 4.0 | O=S(=O)(Cc1ccccc1I)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1 | 10.1021/jm049243i | |||
| 11122117 | 11758 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 4 | 2 | 3 | 4.2 | CCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104953 | 11758 | 0 | None | - | 1 | Human | 6.8 | pKi | = | 6.8 | Binding | ChEMBL | 366 | 4 | 2 | 3 | 4.2 | CCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 122190354 | 130253 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 374 | 4 | 1 | 3 | 4.3 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2Cl)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617554 | 130253 | 0 | None | - | 1 | Human | 5.8 | pKi | = | 5.8 | Binding | ChEMBL | 374 | 4 | 1 | 3 | 4.3 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2Cl)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 10959868 | 11851 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 380 | 5 | 2 | 3 | 4.5 | CCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105478 | 11851 | 0 | None | - | 1 | Human | 7.8 | pKi | = | 7.8 | Binding | ChEMBL | 380 | 5 | 2 | 3 | 4.5 | CCCN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11121708 | 11646 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4F)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104384 | 11646 | 0 | None | 2 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4F)nc23)CC1 | 10.1021/jm030020m | |||
| 11822996 | 11831 | 0 | None | 19 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 308 | 3 | 2 | 4 | 1.7 | CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105327 | 11831 | 0 | None | 19 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 308 | 3 | 2 | 4 | 1.7 | CN1CCC(c2c[nH]c3ccc(NS(C)(=O)=O)nc23)CC1 | 10.1021/jm030020m | |||
| 11003379 | 115878 | 0 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4[N+](=O)[O-])nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL321343 | 115878 | 0 | None | 3 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4[N+](=O)[O-])nc23)CC1 | 10.1021/jm030020m | |||
| 9935387 | 106218 | 0 | None | -251 | 14 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL282971 | 106218 | 0 | None | -251 | 14 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 10287730 | 10309 | 40 | None | -2511 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm049039v | |||
| 77 | 10309 | 40 | None | -2511 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm049039v | |||
| CHEMBL425190 | 10309 | 40 | None | -2511 | 12 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 412 | 6 | 0 | 5 | 4.3 | Cc1ccc2c(n1)cccc2OCCN1CCN(CC1)Cc1cccc2c1nccc2 | 10.1021/jm049039v | |||
| 151 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2015.07.042 | |||
| 20 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2015.07.042 | |||
| 5311258 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL101690 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2015.07.042 | |||
| 151 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2004.09.079 | |||
| 20 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2004.09.079 | |||
| 5311258 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL101690 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1016/j.bmcl.2004.09.079 | |||
| 151 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm030020m | |||
| 20 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm030020m | |||
| 5311258 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm030020m | |||
| CHEMBL101690 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 10.1021/jm030020m | |||
| 44395832 | 129972 | 5 | None | 5 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.3 | CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL361303 | 129972 | 5 | None | 5 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 351 | 3 | 1 | 3 | 4.3 | CN1CCC(n2ccc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 11610526 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1021/acs.jmedchem.2c00633 | |||
| 3928 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1021/acs.jmedchem.2c00633 | |||
| 5351 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL3039520 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1021/acs.jmedchem.2c00633 | |||
| DB11732 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | ChEMBL | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 10.1021/acs.jmedchem.2c00633 | |||
| 10000386 | 66893 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 389 | 3 | 1 | 4 | 4.3 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| CHEMBL173949 | 66893 | 0 | None | - | 1 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 389 | 3 | 1 | 4 | 4.3 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cc(F)cc4F)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| 11098166 | 116564 | 0 | None | 3 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 287 | 2 | 3 | 3 | 2.1 | CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL323264 | 116564 | 0 | None | 3 | 3 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 287 | 2 | 3 | 3 | 2.1 | CNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 11384146 | 208512 | 0 | None | -6 | 9 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 | 10.1021/jm049243i | |||
| CHEMBL606556 | 208512 | 0 | None | -6 | 9 | Human | 8.6 | pKi | = | 8.6 | Binding | ChEMBL | 403 | 5 | 2 | 3 | 4.3 | CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3cccc(Cl)c3)cc12 | 10.1021/jm049243i | |||
| 44386896 | 139063 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| CHEMBL369705 | 139063 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2coc3ccc(NC(=O)c4c(F)cccc4Cl)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| 11728004 | 11225 | 0 | None | 1 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 356 | 8 | 2 | 3 | 4.7 | CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL101686 | 11225 | 0 | None | 1 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 356 | 8 | 2 | 3 | 4.7 | CCCCCCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 11111280 | 115975 | 0 | None | -1 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 364 | 4 | 2 | 4 | 3.6 | COc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL321562 | 115975 | 0 | None | -1 | 3 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 364 | 4 | 2 | 4 | 3.6 | COc1ccccc1C(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 11824009 | 170079 | 0 | None | 33 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 340 | 3 | 2 | 3 | 3.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCCC4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL418806 | 170079 | 0 | None | 33 | 2 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 340 | 3 | 2 | 3 | 3.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCCCC4)nc23)CC1 | 10.1021/jm030020m | |||
| 11747350 | 114109 | 0 | None | -100 | 10 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.4 | CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C | 10.1021/jm010943m | |||
| CHEMBL317535 | 114109 | 0 | None | -100 | 10 | Human | 5.7 | pKi | = | 5.7 | Binding | ChEMBL | 260 | 5 | 1 | 3 | 2.4 | CCOC(=O)c1[nH]c2ccccc2c1CCN(C)C | 10.1021/jm010943m | |||
| 10880608 | 11419 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 284 | 3 | 2 | 3 | 2.6 | CCN1CC=C(c2c[nH]c3ccc(NC(C)=O)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103058 | 11419 | 0 | None | - | 1 | Human | 7.7 | pKi | = | 7.7 | Binding | ChEMBL | 284 | 3 | 2 | 3 | 2.6 | CCN1CC=C(c2c[nH]c3ccc(NC(C)=O)nc23)CC1 | 10.1021/jm030020m | |||
| 11043914 | 11552 | 0 | None | -104 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1cc2c(C3CCN(C)CC3)c[nH]c2cn1 | 10.1021/jm030020m | |||
| CHEMBL104026 | 11552 | 0 | None | -104 | 3 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1cc2c(C3CCN(C)CC3)c[nH]c2cn1 | 10.1021/jm030020m | |||
| 10891048 | 11583 | 0 | None | 2 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 273 | 2 | 2 | 4 | 1.7 | CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL104158 | 11583 | 0 | None | 2 | 4 | Human | 6.7 | pKi | = | 6.7 | Binding | ChEMBL | 273 | 2 | 2 | 4 | 1.7 | CC(=O)Nc1ncc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 10198756 | 11642 | 1 | None | -1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 245 | 2 | 1 | 3 | 2.4 | COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL104374 | 11642 | 1 | None | -1 | 3 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 245 | 2 | 1 | 3 | 2.4 | COc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 122190360 | 130259 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 341 | 4 | 1 | 4 | 3.0 | CN1CCC(C(=O)c2ccnc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617560 | 130259 | 0 | None | - | 1 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 341 | 4 | 1 | 4 | 3.0 | CN1CCC(C(=O)c2ccnc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 11013959 | 114047 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 364 | 4 | 2 | 3 | 4.1 | CCN1CC=C(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL316979 | 114047 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 364 | 4 | 2 | 3 | 4.1 | CCN1CC=C(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 2543 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | |||
| 5358 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | |||
| 54 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | |||
| CHEMBL128 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | |||
| DB00669 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10.1021/jm0155190 | |||
| 6918542 | 211703 | 24 | None | -1258 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.0 | COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| CHEMBL76237 | 211703 | 24 | None | -1258 | 10 | Human | 5.6 | pKi | = | 5.6 | Binding | ChEMBL | 358 | 6 | 0 | 5 | 3.0 | COc1ccc2c(c1)c(CCN(C)C)cn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| 6918648 | 108336 | 1 | None | -407 | 14 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| CHEMBL29846 | 108336 | 1 | None | -407 | 14 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| 6918648 | 108336 | 1 | None | -407 | 14 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29846 | 108336 | 1 | None | -407 | 14 | Human | 6.6 | pKi | = | 6.6 | Binding | ChEMBL | 465 | 5 | 1 | 6 | 4.4 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN(C)CC1 | 10.1016/s0960-894x(02)00172-5 | |||
| 11760896 | 11762 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 388 | 4 | 2 | 4 | 3.3 | CN1CCC(c2c[nH]c3ccc(NS(=O)(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104968 | 11762 | 0 | None | - | 1 | Human | 7.6 | pKi | = | 7.6 | Binding | ChEMBL | 388 | 4 | 2 | 4 | 3.3 | CN1CCC(c2c[nH]c3ccc(NS(=O)(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 9796627 | 103428 | 0 | None | 1 | 7 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 308 | 4 | 1 | 4 | 3.1 | CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12 | 10.1021/jm010943m | |||
| CHEMBL263700 | 103428 | 0 | None | 1 | 7 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 308 | 4 | 1 | 4 | 3.1 | CN(C)CCc1cn(C(=O)c2ccccc2)c2ccc(O)cc12 | 10.1021/jm010943m | |||
| 44387174 | 68547 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| CHEMBL177238 | 68547 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4Cl)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| 9863365 | 68549 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 353 | 3 | 1 | 4 | 4.0 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| CHEMBL177258 | 68549 | 0 | None | - | 1 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 353 | 3 | 1 | 4 | 4.0 | CN1CCC(c2coc3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| 10436045 | 10289 | 4 | None | 1 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| 782 | 10289 | 4 | None | 1 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| CHEMBL432713 | 10289 | 4 | None | 1 | 13 | Human | 8.5 | pKi | = | 8.5 | Binding | ChEMBL | 499 | 9 | 3 | 3 | 6.4 | O=C(/C=C/c1ccc(c(c1)Cl)Cl)NCCCCCN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | 10.1016/s0960-894x(01)00397-3 | |||
| 11372635 | 73861 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL187308 | 73861 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 387 | 3 | 1 | 4 | 4.7 | CN1CCC(c2noc3ccc(NC(=O)c4ccc(F)cc4Cl)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 44352344 | 171149 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 325 | 5 | 2 | 2 | 3.7 | CN(C)CCc1c[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12 | 10.1021/jm0155190 | |||
| CHEMBL421287 | 171149 | 0 | None | - | 1 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 325 | 5 | 2 | 2 | 3.7 | CN(C)CCc1c[nH]c2cccc(NC(=O)c3ccc(F)cc3)c12 | 10.1021/jm0155190 | |||
| 11808793 | 11301 | 0 | None | 10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 3 | 3 | 3 | 2.5 | CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL102292 | 11301 | 0 | None | 10 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 301 | 3 | 3 | 3 | 2.5 | CCNC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 9862256 | 213899 | 0 | None | -2 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| CHEMBL92139 | 213899 | 0 | None | -2 | 9 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| 9950390 | 73025 | 0 | None | 223 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL184597 | 73025 | 0 | None | 223 | 4 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2n[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc23)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 10861816 | 11817 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 380 | 4 | 2 | 3 | 4.5 | CC(C)N1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105240 | 11817 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 380 | 4 | 2 | 3 | 4.5 | CC(C)N1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 6918647 | 107522 | 2 | None | -63 | 14 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| CHEMBL292759 | 107522 | 2 | None | -63 | 14 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 439 | 5 | 1 | 5 | 3.0 | COc1ccc(NS(=O)(=O)c2ccc(Br)cc2)cc1N1CCN(C)CC1 | 10.1021/jm980532e | |||
| 9913554 | 107769 | 0 | None | -398 | 14 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| CHEMBL29433 | 107769 | 0 | None | -398 | 14 | Human | 6.5 | pKi | = | 6.5 | Binding | ChEMBL | 491 | 5 | 1 | 6 | 5.0 | COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1CCN2CCC[C@H]2C1 | 10.1016/s0960-894x(02)00172-5 | |||
| 122190359 | 130257 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 341 | 4 | 1 | 4 | 3.0 | CN1CCC(C(=O)c2cncc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617559 | 130257 | 0 | None | - | 1 | Human | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 341 | 4 | 1 | 4 | 3.0 | CN1CCC(C(=O)c2cncc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 10527469 | 163044 | 3 | None | -7244 | 16 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 448 | 4 | 1 | 7 | 3.0 | COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 | 10.1021/jm970364a | |||
| CHEMBL40650 | 163044 | 3 | None | -7244 | 16 | Rat | 5.5 | pKi | = | 5.5 | Binding | ChEMBL | 448 | 4 | 1 | 7 | 3.0 | COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21 | 10.1021/jm970364a | |||
| 10945589 | 11755 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 272 | 3 | 3 | 3 | 2.4 | CCC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL104946 | 11755 | 0 | None | - | 1 | Human | 7.5 | pKi | = | 7.5 | Binding | ChEMBL | 272 | 3 | 3 | 3 | 2.4 | CCC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1 | 10.1021/jm030020m | |||
| 44395787 | 133561 | 7 | None | 75 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 3 | 1 | 4 | 3.7 | CN1CCC(n2ncc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL365405 | 133561 | 7 | None | 75 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 352 | 3 | 1 | 4 | 3.7 | CN1CCC(n2ncc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 10971452 | 11665 | 0 | None | 1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 402 | 3 | 2 | 3 | 4.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(Cl)cc4Cl)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104496 | 11665 | 0 | None | 1 | 3 | Human | 8.4 | pKi | = | 8.4 | Binding | ChEMBL | 402 | 3 | 2 | 3 | 4.9 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(Cl)cc4Cl)nc23)CC1 | 10.1021/jm030020m | |||
| 11120893 | 11294 | 0 | None | 181 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL102250 | 11294 | 0 | None | 181 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 324 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccoc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11809037 | 11865 | 0 | None | 1 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 309 | 3 | 1 | 5 | 1.7 | CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105556 | 11865 | 0 | None | 1 | 3 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 309 | 3 | 1 | 5 | 1.7 | CN1CCC(c2c[nH]c3ccc(OS(C)(=O)=O)nc23)CC1 | 10.1021/jm030020m | |||
| 44395809 | 129882 | 0 | None | 2 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 353 | 3 | 1 | 3 | 3.5 | CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL361061 | 129882 | 0 | None | 2 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 353 | 3 | 1 | 3 | 3.5 | CN1CCC(N2CCc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 122190352 | 130251 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2cc(F)cc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617552 | 130251 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2cc(F)cc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 11047115 | 11792 | 0 | None | 3 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105118 | 11792 | 0 | None | 3 | 4 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccc([N+](=O)[O-])c4)nc23)CC1 | 10.1021/jm030020m | |||
| 10934159 | 116218 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 258 | 2 | 3 | 3 | 2.0 | CC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL322018 | 116218 | 0 | None | - | 1 | Human | 7.4 | pKi | = | 7.4 | Binding | ChEMBL | 258 | 2 | 3 | 3 | 2.0 | CC(=O)Nc1ccc2[nH]cc(C3CCNCC3)c2n1 | 10.1021/jm030020m | |||
| 9817810 | 24144 | 1 | None | -19 | 8 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 300 | 4 | 1 | 4 | 2.4 | NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| CHEMBL125745 | 24144 | 1 | None | -19 | 8 | Human | 7.3 | pKi | = | 7.3 | Binding | ChEMBL | 300 | 4 | 1 | 4 | 2.4 | NCCc1cccc2c1ccn2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| 10445946 | 174642 | 4 | None | 50 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL431041 | 174642 | 4 | None | 50 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/acs.jmedchem.2c00633 | |||
| 10445946 | 174642 | 4 | None | 50 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL431041 | 174642 | 4 | None | 50 | 4 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 272 | 2 | 2 | 3 | 2.3 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 9798021 | 130248 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 340 | 4 | 1 | 3 | 3.6 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617549 | 130248 | 0 | None | - | 1 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 340 | 4 | 1 | 3 | 3.6 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 9947817 | 11819 | 0 | None | 56 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL105261 | 11819 | 0 | None | 56 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/acs.jmedchem.2c00633 | |||
| 9947817 | 11819 | 0 | None | 56 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL105261 | 11819 | 0 | None | 56 | 9 | Human | 8.3 | pKi | = | 8.3 | Binding | ChEMBL | 286 | 3 | 2 | 3 | 2.7 | CCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 10926112 | 179410 | 0 | None | 17 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 | 10.1021/jm030020m | |||
| CHEMBL449406 | 179410 | 0 | None | 17 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 348 | 3 | 2 | 3 | 3.9 | Cc1cccc(C(=O)Nc2ccc3[nH]cc(C4CCN(C)CC4)c3n2)c1 | 10.1021/jm030020m | |||
| 24865725 | 194863 | 0 | None | -1000 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| CHEMBL497963 | 194863 | 0 | None | -1000 | 12 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 453 | 8 | 1 | 5 | 4.2 | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 | 10.1021/jm8001444 | |||
| 44395810 | 73101 | 0 | None | 1 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 369 | 3 | 1 | 4 | 3.4 | CN1CCC(N2CCOc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL184994 | 73101 | 0 | None | 1 | 3 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 369 | 3 | 1 | 4 | 3.4 | CN1CCC(N2CCOc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 122190353 | 130252 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2ccc(F)c(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617553 | 130252 | 0 | None | - | 1 | Human | 6.3 | pKi | = | 6.3 | Binding | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2ccc(F)c(NC(=O)c3ccc(F)cc3)c2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 9867475 | 24785 | 0 | None | -190 | 9 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 432 | 7 | 0 | 5 | 4.2 | CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| CHEMBL126340 | 24785 | 0 | None | -190 | 9 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 432 | 7 | 0 | 5 | 4.2 | CN(C)CCc1cccc2c1cc(C(=O)c1ccccc1)n2S(=O)(=O)c1ccccc1 | 10.1021/jm010943m | |||
| 5311097 | 63044 | 30 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.0 | CN(C)[C@@H]1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL1628565 | 63044 | 30 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 351 | 3 | 2 | 2 | 4.0 | CN(C)[C@@H]1CCc2[nH]c3ccc(NC(=O)c4ccc(F)cc4)cc3c2C1 | 10.1021/acs.jmedchem.2c00633 | |||
| 11110452 | 11902 | 0 | None | 6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105722 | 11902 | 0 | None | 6 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccn4)nc23)CC1 | 10.1021/jm030020m | |||
| 11044798 | 11940 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 4 | 2 | 3 | 3.1 | CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| CHEMBL105955 | 11940 | 0 | None | - | 1 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 300 | 4 | 2 | 3 | 3.1 | CCCC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2n1 | 10.1021/jm030020m | |||
| 122190356 | 130108 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 370 | 5 | 1 | 4 | 3.6 | COc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3616488 | 130108 | 0 | None | - | 1 | Human | 6.2 | pKi | = | 6.2 | Binding | ChEMBL | 370 | 5 | 1 | 4 | 3.6 | COc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 11141562 | 115976 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 314 | 2 | 2 | 3 | 3.4 | CN1CCC(c2c[nH]c3ccc(NC(=O)C(C)(C)C)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL321578 | 115976 | 0 | None | - | 1 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 314 | 2 | 2 | 3 | 3.4 | CN1CCC(c2c[nH]c3ccc(NC(=O)C(C)(C)C)nc23)CC1 | 10.1021/jm030020m | |||
| 11024618 | 115330 | 0 | None | 2 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 353 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL320198 | 115330 | 0 | None | 2 | 4 | Human | 7.2 | pKi | = | 7.2 | Binding | ChEMBL | 353 | 3 | 2 | 4 | 3.2 | CN1CCC(c2c[nH]c3cnc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11056946 | 115670 | 0 | None | 48 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL321080 | 115670 | 0 | None | 48 | 4 | Human | 8.2 | pKi | = | 8.2 | Binding | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4cccs4)nc23)CC1 | 10.1021/jm030020m | |||
| 11824522 | 11662 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 359 | 3 | 2 | 4 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104484 | 11662 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 359 | 3 | 2 | 4 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(C#N)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11067619 | 11907 | 0 | None | 10 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 3 | 2 | 3 | 3.6 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105743 | 11907 | 0 | None | 10 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 334 | 3 | 2 | 3 | 3.6 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccccc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11046087 | 11719 | 0 | None | 53 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104753 | 11719 | 0 | None | 53 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 340 | 3 | 2 | 4 | 3.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccsc4)nc23)CC1 | 10.1021/jm030020m | |||
| 11101187 | 115238 | 0 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 389 | 4 | 1 | 5 | 3.3 | CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL319920 | 115238 | 0 | None | 3 | 2 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 389 | 4 | 1 | 5 | 3.3 | CN1CCC(c2c[nH]c3ccc(OS(=O)(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 10020895 | 11477 | 0 | None | 7 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| CHEMBL103479 | 11477 | 0 | None | 7 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1016/j.bmcl.2003.09.091 | |||
| 10020895 | 11477 | 0 | None | 7 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL103479 | 11477 | 0 | None | 7 | 8 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 352 | 3 | 2 | 3 | 3.8 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc(F)cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 10872581 | 11701 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104692 | 11701 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 379 | 4 | 2 | 5 | 3.5 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccc([N+](=O)[O-])cc4)nc23)CC1 | 10.1021/jm030020m | |||
| 24893978 | 7797 | 9 | None | -1819 | 8 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 525 | 6 | 2 | 4 | 4.9 | Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2008.06.019 | |||
| 8872 | 7797 | 9 | None | -1819 | 8 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 525 | 6 | 2 | 4 | 4.9 | Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2008.06.019 | |||
| CHEMBL495075 | 7797 | 9 | None | -1819 | 8 | Human | 5.1 | pKi | = | 5.1 | Binding | ChEMBL | 525 | 6 | 2 | 4 | 4.9 | Brc1cc(ccc1OC1CCNCC1)CN1CC[C@@H](C1)NC(=O)c1ccc(c(c1)Cl)Cl | 10.1016/j.bmcl.2008.06.019 | |||
| 10873909 | 11286 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 5.4 | O=C(Nc1ccc2[nH]cc(C3CCN(CCc4ccccc4)CC3)c2n1)c1ccc(F)cc1 | 10.1021/jm030020m | |||
| CHEMBL102182 | 11286 | 0 | None | - | 1 | Human | 7.1 | pKi | = | 7.1 | Binding | ChEMBL | 442 | 6 | 2 | 3 | 5.4 | O=C(Nc1ccc2[nH]cc(C3CCN(CCc4ccccc4)CC3)c2n1)c1ccc(F)cc1 | 10.1021/jm030020m | |||
| 9927441 | 214173 | 0 | None | -229 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12 | 10.1021/jm010943m | |||
| CHEMBL93868 | 214173 | 0 | None | -229 | 9 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 328 | 5 | 0 | 4 | 3.0 | CN(C)CCc1cn(S(=O)(=O)c2ccccc2)c2ccccc12 | 10.1021/jm010943m | |||
| 9840850 | 69265 | 3 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C | 10.1021/acs.jmedchem.2c00633 | |||
| CHEMBL178066 | 69265 | 3 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C | 10.1021/acs.jmedchem.2c00633 | |||
| 44352308 | 124265 | 0 | None | 32 | 12 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | |||
| CHEMBL339980 | 124265 | 0 | None | 32 | 12 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2cccc(NC(=O)c3ccc(F)cc3)c2c1CCN(C)C | 10.1021/jm0155190 | |||
| 9840850 | 69265 | 3 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C | 10.1016/j.bmcl.2003.09.091 | |||
| CHEMBL178066 | 69265 | 3 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 339 | 5 | 2 | 2 | 4.0 | Cc1[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc2c1CCN(C)C | 10.1016/j.bmcl.2003.09.091 | |||
| 122190350 | 130249 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617550 | 130249 | 0 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 358 | 4 | 1 | 3 | 3.7 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 11759467 | 11941 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL105958 | 11941 | 0 | None | 4 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 335 | 3 | 2 | 4 | 3.0 | CN1CCC(c2c[nH]c3ccc(NC(=O)c4ccncc4)nc23)CC1 | 10.1021/jm030020m | |||
| 44395762 | 74008 | 0 | None | 27 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 353 | 3 | 2 | 3 | 3.9 | CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL187952 | 74008 | 0 | None | 27 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 353 | 3 | 2 | 3 | 3.9 | CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 10946905 | 170461 | 0 | None | 43 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 3 | 2 | 3 | 3.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL420475 | 170461 | 0 | None | 43 | 4 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 312 | 3 | 2 | 3 | 3.1 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CCC4)nc23)CC1 | 10.1021/jm030020m | |||
| 122190355 | 130254 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 354 | 4 | 1 | 3 | 3.9 | Cc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617555 | 130254 | 0 | None | - | 1 | Human | 6.1 | pKi | = | 6.1 | Binding | ChEMBL | 354 | 4 | 1 | 3 | 3.9 | Cc1c(NC(=O)c2ccc(F)cc2)cccc1C(=O)C1CCN(C)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 44395762 | 74008 | 0 | None | 27 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 353 | 3 | 2 | 3 | 3.9 | CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL187952 | 74008 | 0 | None | 27 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | ChEMBL | 353 | 3 | 2 | 3 | 3.9 | CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 10308815 | 130256 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 4 | 1 | 4 | 3.0 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| CHEMBL3617557 | 130256 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 341 | 4 | 1 | 4 | 3.0 | CN1CCC(C(=O)c2cccc(NC(=O)c3ccc(F)cc3)n2)CC1 | 10.1016/j.bmcl.2015.07.042 | |||
| 11099817 | 11309 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 338 | 3 | 3 | 3 | 3.4 | O=C(Nc1ccc2[nH]cc(C3CCNCC3)c2n1)c1ccc(F)cc1 | 10.1021/jm030020m | |||
| CHEMBL102335 | 11309 | 0 | None | - | 1 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 338 | 3 | 3 | 3 | 3.4 | O=C(Nc1ccc2[nH]cc(C3CCNCC3)c2n1)c1ccc(F)cc1 | 10.1021/jm030020m | |||
| 44395762 | 74008 | 0 | None | 27 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 353 | 3 | 2 | 3 | 3.9 | CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| CHEMBL187952 | 74008 | 0 | None | 27 | 3 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 353 | 3 | 2 | 3 | 3.9 | CN1CCC(C2CNc3ccc(NC(=O)c4ccc(F)cc4)cc32)CC1 | 10.1016/j.bmcl.2004.09.079 | |||
| 22611622 | 11466 | 8 | None | 6 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 271 | 2 | 2 | 2 | 2.9 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1 | 10.1021/jm030020m | |||
| CHEMBL103424 | 11466 | 8 | None | 6 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 271 | 2 | 2 | 2 | 2.9 | CC(=O)Nc1ccc2[nH]cc(C3CCN(C)CC3)c2c1 | 10.1021/jm030020m | |||
| 11011968 | 11713 | 0 | None | 144 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 298 | 3 | 2 | 3 | 2.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 | 10.1021/jm030020m | |||
| CHEMBL104720 | 11713 | 0 | None | 144 | 4 | Human | 8.0 | pKi | = | 8.0 | Binding | ChEMBL | 298 | 3 | 2 | 3 | 2.7 | CN1CCC(c2c[nH]c3ccc(NC(=O)C4CC4)nc23)CC1 | 10.1021/jm030020m | |||
| 5 | 6927 | 72 | None | -144 | 53 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| 5202 | 6927 | 72 | None | -144 | 53 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| CHEMBL39 | 6927 | 72 | None | -144 | 53 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| DB08839 | 6927 | 72 | None | -144 | 53 | Human | 8.0 | pKd | = | 8 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| 151 | 9194 | 44 | None | 14 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 15900510 | |||
| 20 | 9194 | 44 | None | 14 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 15900510 | |||
| 5311258 | 9194 | 44 | None | 14 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 15900510 | |||
| CHEMBL101690 | 9194 | 44 | None | 14 | 4 | Human | 9.4 | pKd | = | 9.4 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 15900510 | |||
| 1524 | 8962 | 96 | 3H-KETANSERIN | -36 | 51 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 8962 | 96 | 3H-KETANSERIN | -36 | 51 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 8962 | 96 | 3H-KETANSERIN | -36 | 51 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 8962 | 96 | 3H-KETANSERIN | -36 | 51 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 8962 | 96 | 3H-KETANSERIN | -36 | 51 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 8962 | 96 | 3H-KETANSERIN | -36 | 51 | Human | 8.9 | pKi | = | 8.9 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 151 | 9194 | 44 | UNDEFINED | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | None | |||
| 20 | 9194 | 44 | UNDEFINED | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | None | |||
| 5311258 | 9194 | 44 | UNDEFINED | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | None | |||
| CHEMBL101690 | 9194 | 44 | UNDEFINED | 14 | 4 | Human | 8.8 | pKi | = | 8.8 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | None | |||
| 5 | 6927 | 72 | 3H-5HT | -144 | 53 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 6927 | 72 | 3H-5HT | -144 | 53 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 6927 | 72 | 3H-5HT | -144 | 53 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 6927 | 72 | 3H-5HT | -144 | 53 | Human | 8.0 | pKi | = | 8 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 135 | 9310 | 43 | 125I-LSD | -51 | 56 | Mouse | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 9310 | 43 | 125I-LSD | -51 | 56 | Mouse | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 9310 | 43 | 125I-LSD | -51 | 56 | Mouse | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 9310 | 43 | 125I-LSD | -51 | 56 | Mouse | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 9310 | 43 | 125I-LSD | -51 | 56 | Mouse | 7.0 | pKi | = | 7 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4106 | 9280 | 22 | 125I-LSD | -2511 | 33 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 9280 | 22 | 125I-LSD | -2511 | 33 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 9280 | 22 | 125I-LSD | -2511 | 33 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 9280 | 22 | 125I-LSD | -2511 | 33 | Rat | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 28 | 10269 | 46 | 3H-5HT | -602 | 10 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3292447 | 10269 | 46 | 3H-5HT | -602 | 10 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL20963 | 10269 | 46 | 3H-5HT | -602 | 10 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 486 | 9 | 1 | 7 | 5.2 | COc1ccc(cc1OCCN(C)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 115 | 10563 | 80 | 3H-5HT | -24 | 27 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 10563 | 80 | 3H-5HT | -24 | 27 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 10563 | 80 | 3H-5HT | -24 | 27 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 5 | 6927 | 72 | 3H-KETANSERIN | -144 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 6927 | 72 | 3H-KETANSERIN | -144 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 6927 | 72 | 3H-KETANSERIN | -144 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 6927 | 72 | 3H-KETANSERIN | -144 | 53 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 1524 | 8962 | 96 | 3H-5HT | -36 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 8962 | 96 | 3H-5HT | -36 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 8962 | 96 | 3H-5HT | -36 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 8962 | 96 | 3H-5HT | -36 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 8962 | 96 | 3H-5HT | -36 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 8962 | 96 | 3H-5HT | -36 | 51 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 206 | 9271 | 16 | 3H-5HT | -6760 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 68848 | 9271 | 16 | 3H-5HT | -6760 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| CHEMBL12314 | 9271 | 16 | 3H-5HT | -6760 | 25 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 362 | 3 | 1 | 4 | 1.3 | CN1C[C@H](C[C@H]2[C@H]1Cc1cn(c3c1c2ccc3)C)NS(=O)(=O)N(C)C | None | |||
| 2176 | 9901 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 4828 | 9901 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 91 | 9901 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| CHEMBL500 | 9901 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| DB00960 | 9901 | 68 | 3H-5HT | -31622 | 27 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 248 | 6 | 3 | 3 | 1.9 | OC(COc1cccc2c1cc[nH]2)CNC(C)C | None | |||
| 243 | 9976 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3052762 | 9976 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 3502 | 9976 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| CHEMBL117287 | 9976 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| DB06480 | 9976 | 91 | 3H-5HT | -1096 | 34 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 367 | 6 | 2 | 5 | 2.1 | COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N | None | |||
| 130 | 10273 | 47 | 35S-GTPGammaS | -2754 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 3378093 | 10273 | 47 | 35S-GTPGammaS | -2754 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL281350 | 10273 | 47 | 35S-GTPGammaS | -2754 | 13 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 520 | 3 | 0 | 6 | 5.6 | CN1CCC2(CC1)COc1c2cc2c(c1)CCN2C(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 2470 | 10425 | 50 | 3H-5HT | -2089 | 58 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 10425 | 50 | 3H-5HT | -2089 | 58 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 10425 | 50 | 3H-5HT | -2089 | 58 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 10425 | 50 | 3H-5HT | -2089 | 58 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 10425 | 50 | 3H-5HT | -2089 | 58 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 108182 | 10903 | 22 | 3H-5HT | -32 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 245 | 10903 | 22 | 3H-5HT | -32 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| CHEMBL18041 | 10903 | 22 | 3H-5HT | -32 | 17 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 309 | 3 | 2 | 4 | 1.8 | COc1cc(N)c(cc1C(=O)NC1CN2CCC1CC2)Cl | None | |||
| 5656 | 209845 | 87 | 3H-5HT | -79 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | |||
| CHEMBL637 | 209845 | 87 | 3H-5HT | -79 | 43 | Human | 5.0 | pKi | = | 5 | Binding | PDSP KiDatabase | 277 | 5 | 1 | 3 | 3.0 | COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 | None | |||
| 115 | 10563 | 80 | 3H-5HT | -24 | 27 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 10563 | 80 | 3H-5HT | -24 | 27 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 10563 | 80 | 3H-5HT | -24 | 27 | Human | 6.0 | pKi | = | 6 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 107 | 6929 | 121 | 3H-5HT | -1778 | 31 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 1833 | 6929 | 121 | 3H-5HT | -1778 | 31 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| CHEMBL8165 | 6929 | 121 | 3H-5HT | -1778 | 31 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | None | |||
| 135 | 9310 | 43 | 3H-KETANSERIN | -5 | 56 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 9310 | 43 | 3H-KETANSERIN | -5 | 56 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 9310 | 43 | 3H-KETANSERIN | -5 | 56 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 9310 | 43 | 3H-KETANSERIN | -5 | 56 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 9310 | 43 | 3H-KETANSERIN | -5 | 56 | Human | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 2389 | 10104 | 118 | 3H-5HT | -562 | 66 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 10104 | 118 | 3H-5HT | -562 | 66 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 10104 | 118 | 3H-5HT | -562 | 66 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 10104 | 118 | 3H-5HT | -562 | 66 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 10104 | 118 | 3H-5HT | -562 | 66 | Human | 5.9 | pKi | = | 5.9 | Binding | PDSP KiDatabase | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5 | 6927 | 72 | 125I-LSD | -295 | 53 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 6927 | 72 | 125I-LSD | -295 | 53 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 6927 | 72 | 125I-LSD | -295 | 53 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 6927 | 72 | 125I-LSD | -295 | 53 | Mouse | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 134 | 9292 | 24 | 125I-LSD | -11 | 67 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 9292 | 24 | 125I-LSD | -11 | 67 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 9292 | 24 | 125I-LSD | -11 | 67 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 9292 | 24 | 125I-LSD | -11 | 67 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 9292 | 24 | 125I-LSD | -11 | 67 | Rat | 7.9 | pKi | = | 7.9 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 135398737 | 7745 | 93 | 3H-5HT | -19 | 90 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 7745 | 93 | 3H-5HT | -19 | 90 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 7745 | 93 | 3H-5HT | -19 | 90 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 7745 | 93 | 3H-5HT | -19 | 90 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 7745 | 93 | 3H-5HT | -19 | 90 | Human | 6.9 | pKi | = | 6.9 | Binding | PDSP KiDatabase | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| None | 222725 | 0 | 125I-LSD | -112 | 24 | Mouse | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 346 | 5 | 4 | 4 | 2.5 | COC1=CC2=C(C=C1)NC=C2C3=CCNCC3.C(CC(=O)O)C(=O)O | None | |||
| 11954224 | 222732 | 0 | 3H-5HT | -478 | 59 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 11954224 | 222732 | 0 | 3H-5HT | -478 | 59 | Human | 6.8 | pKi | = | 6.8 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 11957541 | 8241 | 40 | 3H-5HT | -436 | 16 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 1229 | 8241 | 40 | 3H-5HT | -436 | 16 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 147 | 8241 | 40 | 3H-5HT | -436 | 16 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 170617 | 8241 | 40 | 3H-5HT | -436 | 16 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| CHEMBL6616 | 8241 | 40 | 3H-5HT | -436 | 16 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 1220 | 6975 | 55 | 3H-5HT | -1318 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 31 | 6975 | 55 | 3H-5HT | -1318 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 7 | 6975 | 55 | 3H-5HT | -1318 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| CHEMBL56 | 6975 | 55 | 3H-5HT | -1318 | 44 | Human | 5.8 | pKi | = | 5.8 | Binding | PDSP KiDatabase | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | None | |||
| 152 | 7152 | 29 | 3H-5HT | -25 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 2107 | 7152 | 29 | 3H-5HT | -25 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| CHEMBL275854 | 7152 | 29 | 3H-5HT | -25 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 152 | 7152 | 29 | 3H-5HT | -25 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| 2107 | 7152 | 29 | 3H-5HT | -25 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| CHEMBL275854 | 7152 | 29 | 3H-5HT | -25 | 19 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | None | |||
| None | 222750 | 0 | 3H-5HT | -446 | 15 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 473 | 7 | 0 | 5 | 3.5 | COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br | None | |||
| None | 222750 | 0 | 3H-5HT | -446 | 15 | Human | 6.7 | pKi | = | 6.7 | Binding | PDSP KiDatabase | 473 | 7 | 0 | 5 | 3.5 | COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br | None | |||
| 2543 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 2337 | 10030 | 77 | 3H-5HT | -35 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 10030 | 77 | 3H-5HT | -35 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 10030 | 77 | 3H-5HT | -35 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 10030 | 77 | 3H-5HT | -35 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 10030 | 77 | 3H-5HT | -35 | 62 | Human | 5.7 | pKi | = | 5.7 | Binding | PDSP KiDatabase | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 2543 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 10479 | 68 | 3H-5HT | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1150 | 10650 | 121 | 3H-5HT | -107 | 25 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 125 | 10650 | 121 | 3H-5HT | -107 | 25 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| CHEMBL6640 | 10650 | 121 | 3H-5HT | -107 | 25 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| DB08653 | 10650 | 121 | 3H-5HT | -107 | 25 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | None | |||
| 1809 | 6922 | 32 | 125I-LSD | -26915 | 37 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 6922 | 32 | 125I-LSD | -26915 | 37 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 6922 | 32 | 125I-LSD | -26915 | 37 | Rat | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 11957541 | 8241 | 40 | 3H-KETANSERIN | -436 | 16 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 1229 | 8241 | 40 | 3H-KETANSERIN | -436 | 16 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 147 | 8241 | 40 | 3H-KETANSERIN | -436 | 16 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 170617 | 8241 | 40 | 3H-KETANSERIN | -436 | 16 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| CHEMBL6616 | 8241 | 40 | 3H-KETANSERIN | -436 | 16 | Human | 5.6 | pKi | = | 5.6 | Binding | PDSP KiDatabase | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | None | |||
| 2470 | 10425 | 50 | 3H-KETANSERIN | -2089 | 58 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 10425 | 50 | 3H-KETANSERIN | -2089 | 58 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 10425 | 50 | 3H-KETANSERIN | -2089 | 58 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 10425 | 50 | 3H-KETANSERIN | -2089 | 58 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 10425 | 50 | 3H-KETANSERIN | -2089 | 58 | Human | 8.4 | pKi | = | 8.4 | Binding | PDSP KiDatabase | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| None | 222831 | 0 | 3H-5HT | -87 | 8 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 339 | 4 | 3 | 3 | 1.9 | CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C | None | |||
| None | 222831 | 0 | 3H-5HT | -87 | 8 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 339 | 4 | 3 | 3 | 1.9 | CCC(CO)NC(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C | None | |||
| 10257 | 7525 | 31 | 125I-LSD | -12 | 19 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| 144 | 7525 | 31 | 125I-LSD | -12 | 19 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| CHEMBL416526 | 7525 | 31 | 125I-LSD | -12 | 19 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| DB01445 | 7525 | 31 | 125I-LSD | -12 | 19 | Mouse | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 204 | 3 | 2 | 2 | 2.0 | CN(CCc1c[nH]c2c1cc(O)cc2)C | None | |||
| 135398745 | 9688 | 112 | 3H-5HT | -43 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 9688 | 112 | 3H-5HT | -43 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 9688 | 112 | 3H-5HT | -43 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 9688 | 112 | 3H-5HT | -43 | 65 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 3652 | 10869 | 79 | 3H-5HT | -12 | 18 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 57 | 10869 | 79 | 3H-5HT | -12 | 18 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 60809 | 10869 | 79 | 3H-5HT | -12 | 18 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| CHEMBL21536 | 10869 | 79 | 3H-5HT | -12 | 18 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| DB15357 | 10869 | 79 | 3H-5HT | -12 | 18 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 1809 | 6922 | 32 | 125I-LSD | -34673 | 37 | Mouse | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 6922 | 32 | 125I-LSD | -34673 | 37 | Mouse | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 6922 | 32 | 125I-LSD | -34673 | 37 | Mouse | 5.5 | pKi | = | 5.5 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 134 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 133 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 134 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 9292 | 24 | 3H-5HT | -10 | 67 | Human | 7.5 | pKi | = | 7.5 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 133 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 9274 | 52 | 3H-5HT | -165 | 43 | Human | 6.5 | pKi | = | 6.5 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 2435 | 10362 | 83 | 3H-5HT | -190 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 10362 | 83 | 3H-5HT | -190 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 10362 | 83 | 3H-5HT | -190 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 10362 | 83 | 3H-5HT | -190 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 10362 | 83 | 3H-5HT | -190 | 48 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 145 | 6928 | 49 | 3H-5HT | -7 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 6928 | 49 | 3H-5HT | -7 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 6928 | 49 | 3H-5HT | -7 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 6928 | 49 | 3H-5HT | -7 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 145 | 6928 | 49 | 3H-5HT | -7 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1832 | 6928 | 49 | 3H-5HT | -7 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL7257 | 6928 | 49 | 3H-5HT | -7 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB14010 | 6928 | 49 | 3H-5HT | -7 | 30 | Human | 7.4 | pKi | = | 7.4 | Binding | PDSP KiDatabase | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 6852400 | 222716 | 0 | 3H-KETANSERIN | -9772 | 22 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | |||
| 73759726 | 222716 | 0 | 3H-KETANSERIN | -9772 | 22 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 361 | 0 | 1 | 2 | 4.8 | CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O | None | |||
| 107780 | 8625 | 54 | 3H-5HT | -269 | 18 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 14 | 8625 | 54 | 3H-5HT | -269 | 18 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| CHEMBL15928 | 8625 | 54 | 3H-5HT | -269 | 18 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | None | |||
| 1574 | 6869 | 60 | 3H-5HT | -4 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 6869 | 60 | 3H-5HT | -4 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 6869 | 60 | 3H-5HT | -4 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 1574 | 6869 | 60 | 3H-5HT | -4 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 218 | 6869 | 60 | 3H-5HT | -4 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| CHEMBL266591 | 6869 | 60 | 3H-5HT | -4 | 21 | Human | 6.4 | pKi | = | 6.4 | Binding | PDSP KiDatabase | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | None | |||
| 202 | 8290 | 77 | 3H-5HT | -1 | 33 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 60835 | 8290 | 77 | 3H-5HT | -1 | 33 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 972 | 8290 | 77 | 3H-5HT | -1 | 33 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| CHEMBL1175 | 8290 | 77 | 3H-5HT | -1 | 33 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| DB00476 | 8290 | 77 | 3H-5HT | -1 | 33 | Human | 5.4 | pKi | = | 5.4 | Binding | PDSP KiDatabase | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 2337 | 10030 | 77 | None | -35 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 50 | 10030 | 77 | None | -35 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 5002 | 10030 | 77 | None | -35 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| CHEMBL716 | 10030 | 77 | None | -35 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| DB01224 | 10030 | 77 | None | -35 | 62 | Human | 8.3 | pKi | = | 8.3 | Binding | Drug Central | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | None | |||
| 2389 | 10104 | 118 | None | -562 | 66 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 5073 | 10104 | 118 | None | -562 | 66 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 96 | 10104 | 118 | None | -562 | 66 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| CHEMBL85 | 10104 | 118 | None | -562 | 66 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| DB00734 | 10104 | 118 | None | -562 | 66 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | None | |||
| 11954224 | 222732 | 0 | 125I-LSD | -707 | 59 | Mouse | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 1353 | 8692 | 93 | 3H-5HT | -112 | 85 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 8692 | 93 | 3H-5HT | -112 | 85 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 8692 | 93 | 3H-5HT | -112 | 85 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 8692 | 93 | 3H-5HT | -112 | 85 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 8692 | 93 | 3H-5HT | -112 | 85 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 2181 | 9902 | 46 | 3H-5HT | -134 | 34 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 4830 | 9902 | 46 | 3H-5HT | -134 | 34 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 92 | 9902 | 46 | 3H-5HT | -134 | 34 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| CHEMBL440294 | 9902 | 46 | 3H-5HT | -134 | 34 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| DB09286 | 9902 | 46 | 3H-5HT | -134 | 34 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 189 | 10265 | 39 | 3H-5HT | -2089 | 17 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | |||
| 5163 | 10265 | 39 | 3H-5HT | -2089 | 17 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | |||
| CHEMBL297784 | 10265 | 39 | 3H-5HT | -2089 | 17 | Human | 5.3 | pKi | = | 5.3 | Binding | PDSP KiDatabase | 292 | 1 | 1 | 3 | 3.2 | O=C(N1CCc2c1cc1ccn(c1c2)C)Nc1cccnc1 | None | |||
| 133 | 9274 | 52 | 3H-5HT | -954 | 43 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 9274 | 52 | 3H-5HT | -954 | 43 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 9274 | 52 | 3H-5HT | -954 | 43 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 9274 | 52 | 3H-5HT | -954 | 43 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 9274 | 52 | 3H-5HT | -954 | 43 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 11954224 | 222732 | 0 | 125I-LSD | -741 | 59 | Rat | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 1342 | 6824 | 49 | 3H-5HT | -21 | 19 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 6824 | 49 | 3H-5HT | -21 | 19 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 6824 | 49 | 3H-5HT | -21 | 19 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 1342 | 6824 | 49 | 3H-5HT | -21 | 19 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 3 | 6824 | 49 | 3H-5HT | -21 | 19 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| CHEMBL277120 | 6824 | 49 | 3H-5HT | -21 | 19 | Human | 7.3 | pKi | = | 7.3 | Binding | PDSP KiDatabase | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | None | |||
| 102 | 10899 | 48 | 125I-LSD | -1412 | 49 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 10899 | 48 | 125I-LSD | -1412 | 49 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 10899 | 48 | 125I-LSD | -1412 | 49 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 10899 | 48 | 125I-LSD | -1412 | 49 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 10899 | 48 | 125I-LSD | -1412 | 49 | Rat | 6.3 | pKi | = | 6.3 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 18971832 | 9196 | 0 | 3H-5HT | 83 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| 21 | 9196 | 0 | 3H-5HT | 83 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| CHEMBL3186179 | 9196 | 0 | 3H-5HT | 83 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | None | |||
| 134 | 9292 | 24 | 125I-LSD | -5 | 67 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 9292 | 24 | 125I-LSD | -5 | 67 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 9292 | 24 | 125I-LSD | -5 | 67 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 9292 | 24 | 125I-LSD | -5 | 67 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 9292 | 24 | 125I-LSD | -5 | 67 | Mouse | 8.2 | pKi | = | 8.2 | Binding | PDSP KiDatabase | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 2435 | 10362 | 83 | None | -190 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 60149 | 10362 | 83 | None | -190 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 98 | 10362 | 83 | None | -190 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| CHEMBL12713 | 10362 | 83 | None | -190 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| DB06144 | 10362 | 83 | None | -190 | 48 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | None | |||
| 133 | 9274 | 52 | None | -165 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 1723 | 9274 | 52 | None | -165 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 28693 | 9274 | 52 | None | -165 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| CHEMBL19215 | 9274 | 52 | None | -165 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| DB13520 | 9274 | 52 | None | -165 | 43 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | None | |||
| 3652 | 10869 | 79 | None | -12 | 18 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 57 | 10869 | 79 | None | -12 | 18 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 60809 | 10869 | 79 | None | -12 | 18 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| CHEMBL21536 | 10869 | 79 | None | -12 | 18 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| DB15357 | 10869 | 79 | None | -12 | 18 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | None | |||
| 135398745 | 9688 | 112 | None | -43 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 47 | 9688 | 112 | None | -43 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| CHEMBL715 | 9688 | 112 | None | -43 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| DB00334 | 9688 | 112 | None | -43 | 65 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | None | |||
| 2393 | 10107 | 82 | None | -3 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 5078 | 10107 | 82 | None | -3 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 51 | 10107 | 82 | None | -3 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| CHEMBL905 | 10107 | 82 | None | -3 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| DB00953 | 10107 | 82 | None | -3 | 5 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | None | |||
| 11954224 | 222732 | 0 | None | -478 | 59 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 581 | 4 | 3 | 6 | 2.0 | CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C | None | |||
| 135398737 | 7745 | 93 | None | -19 | 90 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 38 | 7745 | 93 | None | -19 | 90 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 722 | 7745 | 93 | None | -19 | 90 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| CHEMBL42 | 7745 | 93 | None | -19 | 90 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| DB00363 | 7745 | 93 | None | -19 | 90 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | None | |||
| 102 | 10899 | 48 | 125I-LSD | -158 | 49 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 10899 | 48 | 125I-LSD | -158 | 49 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 10899 | 48 | 125I-LSD | -158 | 49 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 10899 | 48 | 125I-LSD | -158 | 49 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 10899 | 48 | 125I-LSD | -158 | 49 | Mouse | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| None | 222993 | 0 | 3H-5HT | -562 | 14 | Human | 5.2 | pKi | = | 5.2 | Binding | PDSP KiDatabase | 438 | 5 | 1 | 4 | 4.8 | C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45 | None | |||
| 2543 | 10479 | 68 | 125I-LSD | -18 | 32 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 10479 | 68 | 125I-LSD | -18 | 32 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 10479 | 68 | 125I-LSD | -18 | 32 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 10479 | 68 | 125I-LSD | -18 | 32 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 10479 | 68 | 125I-LSD | -18 | 32 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 4106 | 9280 | 22 | 3H-5HT | -1584 | 33 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 9280 | 22 | 3H-5HT | -1584 | 33 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 9280 | 22 | 3H-5HT | -1584 | 33 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 9280 | 22 | 3H-5HT | -1584 | 33 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 4106 | 9280 | 22 | 3H-5HT | -1584 | 33 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5358812 | 9280 | 22 | 3H-5HT | -1584 | 33 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 89 | 9280 | 22 | 3H-5HT | -1584 | 33 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| CHEMBL93240 | 9280 | 22 | 3H-5HT | -1584 | 33 | Human | 6.2 | pKi | = | 6.2 | Binding | PDSP KiDatabase | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | None | |||
| 5 | 6927 | 72 | 125I-LSD | -158 | 53 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 5202 | 6927 | 72 | 125I-LSD | -158 | 53 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL39 | 6927 | 72 | 125I-LSD | -158 | 53 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| DB08839 | 6927 | 72 | 125I-LSD | -158 | 53 | Rat | 7.2 | pKi | = | 7.2 | Binding | PDSP KiDatabase | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | None | |||
| 102 | 10899 | 48 | None | -100 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 10899 | 48 | None | -100 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 10899 | 48 | None | -100 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 10899 | 48 | None | -100 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 10899 | 48 | None | -100 | 49 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 10531 | 8202 | 21 | None | -83 | 24 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 121 | 8202 | 21 | None | -83 | 24 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 888 | 8202 | 21 | None | -83 | 24 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| CHEMBL1732 | 8202 | 21 | None | -83 | 24 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| DB00320 | 8202 | 21 | None | -83 | 24 | Human | 8.2 | pKi | = | 8.2 | Binding | Drug Central | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | None | |||
| 123606 | 7140 | 70 | None | 1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| 128 | 7140 | 70 | None | 1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| 7110 | 7140 | 70 | None | 1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| CHEMBL1505 | 7140 | 70 | None | 1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| DB00918 | 7140 | 70 | None | 1 | 3 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 6 | 1 | 3 | 2.2 | CN(CCc1c[nH]c2c1cc(cc2)CS(=O)(=O)N1CCCC1)C | None | |||
| 2869 | 10924 | 89 | None | -25 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 60 | 10924 | 89 | None | -25 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 60857 | 10924 | 89 | None | -25 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| CHEMBL1185 | 10924 | 89 | None | -25 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| DB00315 | 10924 | 89 | None | -25 | 7 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | None | |||
| 150 | 9287 | 21 | None | -11 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 1764 | 9287 | 21 | None | -11 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 8226 | 9287 | 21 | None | -11 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| CHEMBL1201356 | 9287 | 21 | None | -11 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| DB00353 | 9287 | 21 | None | -11 | 16 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | None | |||
| 2543 | 10479 | 68 | None | -5 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 10479 | 68 | None | -5 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 10479 | 68 | None | -5 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 10479 | 68 | None | -5 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 10479 | 68 | None | -5 | 32 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 1809 | 6922 | 32 | 3H-5HT | -8317 | 37 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 6922 | 32 | 3H-5HT | -8317 | 37 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 6922 | 32 | 3H-5HT | -8317 | 37 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 1809 | 6922 | 32 | 3H-5HT | -8317 | 37 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 4 | 6922 | 32 | 3H-5HT | -8317 | 37 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| CHEMBL18840 | 6922 | 32 | 3H-5HT | -8317 | 37 | Human | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | None | |||
| 2543 | 10479 | 68 | 125I-LSD | -22 | 32 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 5358 | 10479 | 68 | 125I-LSD | -22 | 32 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 54 | 10479 | 68 | 125I-LSD | -22 | 32 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| CHEMBL128 | 10479 | 68 | 125I-LSD | -22 | 32 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| DB00669 | 10479 | 68 | 125I-LSD | -22 | 32 | Mouse | 7.1 | pKi | = | 7.1 | Binding | PDSP KiDatabase | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | None | |||
| 115 | 10563 | 80 | 125I-LSD | -19 | 27 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| 4296 | 10563 | 80 | 125I-LSD | -19 | 27 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| CHEMBL274866 | 10563 | 80 | 125I-LSD | -19 | 27 | Mouse | 6.1 | pKi | = | 6.1 | Binding | PDSP KiDatabase | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | None | |||
| None | 223229 | 0 | 3H-5HT | -524 | 28 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | |||
| None | 223229 | 0 | UNDEFINED | -524 | 28 | Human | 5.1 | pKi | = | 5.1 | Binding | PDSP KiDatabase | 322 | 5 | 2 | 3 | 4.1 | CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl | None | |||
| 40 | 8329 | 58 | None | -2 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 77993 | 8329 | 58 | None | -2 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 995 | 8329 | 58 | None | -2 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| CHEMBL1510 | 8329 | 58 | None | -2 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| DB00216 | 8329 | 58 | None | -2 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | None | |||
| 135 | 9310 | 43 | None | -5 | 56 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 1796 | 9310 | 43 | None | -5 | 56 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 4184 | 9310 | 43 | None | -5 | 56 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| CHEMBL6437 | 9310 | 43 | None | -5 | 56 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| DB06148 | 9310 | 43 | None | -5 | 56 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 264 | 0 | 0 | 2 | 3.1 | CN1CCN2C(C1)c1ccccc1Cc1c2cccc1 | None | |||
| 134 | 9292 | 24 | None | -10 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1775 | 9292 | 24 | None | -10 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 9681 | 9292 | 24 | None | -10 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| CHEMBL1065 | 9292 | 24 | None | -10 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| DB00247 | 9292 | 24 | None | -10 | 67 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | None | |||
| 1884 | 9512 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 4440 | 9512 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 45 | 9512 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| CHEMBL1278 | 9512 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| DB00952 | 9512 | 58 | None | -3 | 5 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | None | |||
| 2470 | 10425 | 50 | None | -2089 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 3300 | 10425 | 50 | None | -2089 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 5265 | 10425 | 50 | None | -2089 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 99 | 10425 | 50 | None | -2089 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| CHEMBL267930 | 10425 | 50 | None | -2089 | 58 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 6 | 1 | 4 | 3.2 | Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1 | None | |||
| 11610526 | 9062 | 64 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | None | |||
| 3928 | 9062 | 64 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | None | |||
| 5351 | 9062 | 64 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | None | |||
| CHEMBL3039520 | 9062 | 64 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | None | |||
| DB11732 | 9062 | 64 | None | - | 1 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | None | |||
| 1524 | 8962 | 96 | None | -36 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 197 | 8962 | 96 | None | -36 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 3822 | 8962 | 96 | None | -36 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 88 | 8962 | 96 | None | -36 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| CHEMBL51 | 8962 | 96 | None | -36 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| DB12465 | 8962 | 96 | None | -36 | 51 | Human | 8.1 | pKi | = | 8.1 | Binding | Drug Central | 395 | 5 | 1 | 5 | 2.4 | Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2 | None | |||
| 102 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 102 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 3659 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 8969 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| CHEMBL15245 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| DB01392 | 10899 | 48 | 3H-5HT | -100 | 49 | Human | 7.0 | pKi | = | 7.0 | Binding | PDSP KiDatabase | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | None | |||
| 2543 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 2543 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15900510 | |||
| 2543 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 2543 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 9225282 | |||
| 5358 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 5358 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15900510 | |||
| 5358 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 5358 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 9225282 | |||
| 54 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| 54 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15900510 | |||
| 54 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 54 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 9225282 | |||
| CHEMBL128 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| CHEMBL128 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15900510 | |||
| CHEMBL128 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| CHEMBL128 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 9225282 | |||
| DB00669 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 10193663 | |||
| DB00669 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 15900510 | |||
| DB00669 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| DB00669 | 10479 | 68 | None | -5 | 32 | Human | 7.6 | pKi | = | 7.6 | Binding | Guide to Pharmacology | 295 | 6 | 2 | 3 | 1.3 | CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 9225282 | |||
| 40 | 8329 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 77993 | 8329 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 995 | 8329 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| CHEMBL1510 | 8329 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| DB00216 | 8329 | 58 | None | -2 | 5 | Human | 8.0 | pKi | = | 8 | Binding | Guide to Pharmacology | 382 | 6 | 1 | 3 | 3.8 | CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1 | 10193663 | |||
| 18971832 | 9196 | 0 | None | 83 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| 21 | 9196 | 0 | None | 83 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| CHEMBL3186179 | 9196 | 0 | None | 83 | 13 | Human | 8.2 | pKi | = | 8.2 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.0 | CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C | 9395253 | |||
| 8422 | 6917 | 0 | None | 66 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 272 | 7 | 1 | 2 | 3.2 | CCCC(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 21422162 | |||
| 91827360 | 6917 | 0 | None | 66 | 2 | Human | 8.4 | pKi | = | 8.4 | Binding | Guide to Pharmacology | 272 | 7 | 1 | 2 | 3.2 | CCCC(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 21422162 | |||
| 11610526 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 20855361 | |||
| 3928 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 20855361 | |||
| 5351 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 20855361 | |||
| CHEMBL3039520 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 20855361 | |||
| DB11732 | 9062 | 64 | None | - | 1 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 377 | 4 | 1 | 4 | 3.3 | CN1CCC(CC1)C(=O)c1cccc(n1)NC(=O)c1c(F)cc(cc1F)F | 20855361 | |||
| 151 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 15900510 | |||
| 20 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 15900510 | |||
| 5311258 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 15900510 | |||
| CHEMBL101690 | 9194 | 44 | None | 14 | 4 | Human | 8.7 | pKi | = | 8.7 | Binding | Guide to Pharmacology | 351 | 3 | 2 | 2 | 4.4 | CN1CCC(CC1)c1c[nH]c2c1cc(cc2)NC(=O)c1ccc(cc1)F | 15900510 | |||
| 2438 | 7514 | 92 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 230 | 1 | 2 | 2 | 2.7 | CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | None | |||
| 3927 | 7514 | 92 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 230 | 1 | 2 | 2 | 2.7 | CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | None | |||
| CHEMBL1371156 | 7514 | 92 | None | 1 | 2 | Human | 8.9 | pKi | = | 8.9 | Binding | Guide to Pharmacology | 230 | 1 | 2 | 2 | 2.7 | CN1CCC(CC1)c1c[nH]c2c1cc(O)cc2 | None | |||
| 1353 | 8692 | 93 | None | -112 | 85 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 3559 | 8692 | 93 | None | -112 | 85 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 86 | 8692 | 93 | None | -112 | 85 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| CHEMBL54 | 8692 | 93 | None | -112 | 85 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| DB00502 | 8692 | 93 | None | -112 | 85 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 6 | 1 | 3 | 4.4 | Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl | None | |||
| 2181 | 9902 | 46 | None | -134 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 4830 | 9902 | 46 | None | -134 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 92 | 9902 | 46 | None | -134 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| CHEMBL440294 | 9902 | 46 | None | -134 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| DB09286 | 9902 | 46 | None | -134 | 34 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 375 | 7 | 1 | 4 | 2.6 | O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N | None | |||
| 202 | 8290 | 77 | None | -1 | 33 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 60835 | 8290 | 77 | None | -1 | 33 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 972 | 8290 | 77 | None | -1 | 33 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| CHEMBL1175 | 8290 | 77 | None | -1 | 33 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| DB00476 | 8290 | 77 | None | -1 | 33 | Human | 8.3 | pKi | None | 8.3 | Binding | Drug Central | 297 | 6 | 1 | 3 | 4.6 | CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 | None | |||
| 197706 | 8246 | 0 | None | -15848 | 10 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| 39 | 8246 | 0 | None | -15848 | 10 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| CHEMBL1742428 | 8246 | 0 | None | -15848 | 10 | Human | 5.5 | pKi | None | 5.5 | Binding | Guide to Pharmacology | 403 | 6 | 2 | 5 | 2.3 | NCCc1c[nH]c2c1cc(OCC(=O)N1CCN(CC1)c1ccc(cc1)C#N)cc2 | 10381763 | |||
| 2337 | 10030 | 77 | None | -35 | 62 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| 50 | 10030 | 77 | None | -35 | 62 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| 5002 | 10030 | 77 | None | -35 | 62 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| CHEMBL716 | 10030 | 77 | None | -35 | 62 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| DB01224 | 10030 | 77 | None | -35 | 62 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 383 | 5 | 1 | 6 | 2.9 | OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2 | 8935801 | |||
| 1150 | 10650 | 121 | None | -107 | 25 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 8380639 | |||
| 125 | 10650 | 121 | None | -107 | 25 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 8380639 | |||
| CHEMBL6640 | 10650 | 121 | None | -107 | 25 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 8380639 | |||
| DB08653 | 10650 | 121 | None | -107 | 25 | Human | 5.6 | pKi | None | 5.6 | Binding | Guide to Pharmacology | 160 | 2 | 2 | 1 | 1.7 | NCCc1c[nH]c2c1cccc2 | 8380639 | |||
| 1220 | 6975 | 55 | None | -1318 | 44 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 8380639 | |||
| 31 | 6975 | 55 | None | -1318 | 44 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 8380639 | |||
| 7 | 6975 | 55 | None | -1318 | 44 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 8380639 | |||
| CHEMBL56 | 6975 | 55 | None | -1318 | 44 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 247 | 5 | 1 | 2 | 3.4 | CCCN(C1CCc2c(C1)c(O)ccc2)CCC | 8380639 | |||
| 122 | 8219 | 9 | None | -316 | 11 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| 156314 | 8219 | 9 | None | -316 | 11 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| CHEMBL1332062 | 8219 | 9 | None | -316 | 11 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 287 | 8 | 2 | 2 | 2.9 | CCCN(CCC)CCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| 11957541 | 8241 | 40 | None | -436 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| 1229 | 8241 | 40 | None | -436 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| 147 | 8241 | 40 | None | -436 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| 170617 | 8241 | 40 | None | -436 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| CHEMBL6616 | 8241 | 40 | None | -436 | 16 | Human | 5.8 | pKi | None | 5.8 | Binding | Guide to Pharmacology | 321 | 4 | 1 | 3 | 2.2 | COc1cc(I)c(cc1CC(N)C)OC | 8380639 | |||
| 107 | 6929 | 121 | None | -1778 | 31 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8380639 | |||
| 1833 | 6929 | 121 | None | -1778 | 31 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8380639 | |||
| CHEMBL8165 | 6929 | 121 | None | -1778 | 31 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 190 | 3 | 2 | 2 | 1.7 | NCCc1c[nH]c2c1cc(OC)cc2 | 8380639 | |||
| 2389 | 10104 | 118 | None | -562 | 66 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 5073 | 10104 | 118 | None | -562 | 66 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 96 | 10104 | 118 | None | -562 | 66 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| CHEMBL85 | 10104 | 118 | None | -562 | 66 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| DB00734 | 10104 | 118 | None | -562 | 66 | Human | 5.9 | pKi | None | 5.9 | Binding | Guide to Pharmacology | 410 | 4 | 0 | 6 | 3.6 | Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2 | 8935801 | |||
| 10 | 7510 | 28 | None | -79 | 9 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| 3654103 | 7510 | 28 | None | -79 | 9 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| CHEMBL534232 | 7510 | 28 | None | -79 | 9 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 406 | 6 | 1 | 3 | 4.7 | Clc1cccc(c1)N1CCN(CC1)CC(C(c1ccccc1)c1ccccc1)O | 9303567 | |||
| 115 | 10563 | 80 | None | -24 | 27 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8380639 | |||
| 4296 | 10563 | 80 | None | -24 | 27 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8380639 | |||
| CHEMBL274866 | 10563 | 80 | None | -24 | 27 | Human | 6.0 | pKi | None | 6 | Binding | Guide to Pharmacology | 230 | 1 | 1 | 2 | 2.1 | FC(c1cccc(c1)N1CCNCC1)(F)F | 8380639 | |||
| 1809 | 6922 | 32 | None | -8317 | 37 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| 1809 | 6922 | 32 | None | -8317 | 37 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 9225282 | |||
| 4 | 6922 | 32 | None | -8317 | 37 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| 4 | 6922 | 32 | None | -8317 | 37 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 9225282 | |||
| CHEMBL18840 | 6922 | 32 | None | -8317 | 37 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 8380639 | |||
| CHEMBL18840 | 6922 | 32 | None | -8317 | 37 | Human | 6.1 | pKi | None | 6.1 | Binding | Guide to Pharmacology | 203 | 3 | 3 | 2 | 0.8 | NCCc1c[nH]c2c1cc(cc2)C(=O)N | 9225282 | |||
| 4106 | 9280 | 22 | None | -1584 | 33 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8380639 | |||
| 4106 | 9280 | 22 | None | -1584 | 33 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 9225282 | |||
| 5358812 | 9280 | 22 | None | -1584 | 33 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8380639 | |||
| 5358812 | 9280 | 22 | None | -1584 | 33 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 9225282 | |||
| 89 | 9280 | 22 | None | -1584 | 33 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8380639 | |||
| 89 | 9280 | 22 | None | -1584 | 33 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 9225282 | |||
| CHEMBL93240 | 9280 | 22 | None | -1584 | 33 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 8380639 | |||
| CHEMBL93240 | 9280 | 22 | None | -1584 | 33 | Human | 6.2 | pKi | None | 6.2 | Binding | Guide to Pharmacology | 356 | 2 | 0 | 4 | 4.4 | CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C | 9225282 | |||
| 1574 | 6869 | 60 | None | -4 | 21 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 8380639 | |||
| 218 | 6869 | 60 | None | -4 | 21 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 8380639 | |||
| CHEMBL266591 | 6869 | 60 | None | -4 | 21 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.7 | Cc1c(CCN)c2c([nH]1)ccc(c2)O | 8380639 | |||
| 2435 | 10362 | 83 | None | -190 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 60149 | 10362 | 83 | None | -190 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 98 | 10362 | 83 | None | -190 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| CHEMBL12713 | 10362 | 83 | None | -190 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| DB06144 | 10362 | 83 | None | -190 | 48 | Human | 6.4 | pKi | None | 6.4 | Binding | Guide to Pharmacology | 440 | 5 | 1 | 3 | 4.6 | Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O | 8935801 | |||
| 133 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8380639 | |||
| 133 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 9225282 | |||
| 1723 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8380639 | |||
| 1723 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 9225282 | |||
| 28693 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8380639 | |||
| 28693 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 9225282 | |||
| CHEMBL19215 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8380639 | |||
| CHEMBL19215 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 9225282 | |||
| DB13520 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 8380639 | |||
| DB13520 | 9274 | 52 | None | -165 | 43 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 403 | 4 | 1 | 4 | 4.1 | O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C | 9225282 | |||
| 135398745 | 9688 | 112 | None | -43 | 65 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| 47 | 9688 | 112 | None | -43 | 65 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| CHEMBL715 | 9688 | 112 | None | -43 | 65 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| DB00334 | 9688 | 112 | None | -43 | 65 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 312 | 1 | 1 | 5 | 1.7 | CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C | 8935801 | |||
| 3652 | 10869 | 79 | None | -12 | 18 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 57 | 10869 | 79 | None | -12 | 18 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 60809 | 10869 | 79 | None | -12 | 18 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| CHEMBL21536 | 10869 | 79 | None | -12 | 18 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| DB15357 | 10869 | 79 | None | -12 | 18 | Human | 6.5 | pKi | None | 6.5 | Binding | Guide to Pharmacology | 281 | 7 | 0 | 5 | 3.2 | CCCCCCOc1nsnc1C1=CCCN(C1)C | 9884068 | |||
| 2393 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 2393 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 15900510 | |||
| 5078 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 5078 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 15900510 | |||
| 51 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| 51 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 15900510 | |||
| CHEMBL905 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| CHEMBL905 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 15900510 | |||
| DB00953 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 10193663 | |||
| DB00953 | 10107 | 82 | None | -3 | 5 | Human | 6.6 | pKi | None | 6.6 | Binding | Guide to Pharmacology | 269 | 5 | 1 | 4 | 1.9 | CN(CCc1c[nH]c2c1cc(cc2)Cn1cncn1)C | 15900510 | |||
| 152 | 7152 | 29 | None | -25 | 19 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8380639 | |||
| 2107 | 7152 | 29 | None | -25 | 19 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8380639 | |||
| CHEMBL275854 | 7152 | 29 | None | -25 | 19 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 190 | 2 | 3 | 2 | 1.8 | CC(Cc1c[nH]c2c1cc(O)cc2)N | 8380639 | |||
| 4431 | 9506 | 25 | None | -575 | 12 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 8380639 | |||
| 73 | 9506 | 25 | None | -575 | 12 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 8380639 | |||
| CHEMBL8618 | 9506 | 25 | None | -575 | 12 | Human | 6.7 | pKi | None | 6.7 | Binding | Guide to Pharmacology | 393 | 7 | 0 | 5 | 2.9 | COc1ccccc1N1CCN(CC1)CCCCN1C(=O)c2c(C1=O)cccc2 | 8380639 | |||
| 107780 | 8625 | 54 | None | -269 | 18 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 15900510 | |||
| 107780 | 8625 | 54 | None | -269 | 18 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| 14 | 8625 | 54 | None | -269 | 18 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 15900510 | |||
| 14 | 8625 | 54 | None | -269 | 18 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| CHEMBL15928 | 8625 | 54 | None | -269 | 18 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 15900510 | |||
| CHEMBL15928 | 8625 | 54 | None | -269 | 18 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 497 | 6 | 1 | 7 | 5.0 | COc1ccc(cc1N1CCN(CC1)C)NC(=O)c1ccc(cc1)c1ccc(cc1C)c1noc(n1)C | 9303567 | |||
| 1043 | 8363 | 14 | None | -1737 | 29 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| 149 | 8363 | 14 | None | -1737 | 29 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| 8223 | 8363 | 14 | None | -1737 | 29 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| CHEMBL442 | 8363 | 14 | None | -1737 | 29 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| DB00696 | 8363 | 14 | None | -1737 | 29 | Human | 6.8 | pKi | None | 6.8 | Binding | Guide to Pharmacology | 581 | 4 | 3 | 6 | 2.0 | O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 8380639 | |||
| 10531 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 15900510 | |||
| 10531 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 9225282 | |||
| 121 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 15900510 | |||
| 121 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 9225282 | |||
| 888 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 15900510 | |||
| 888 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 9225282 | |||
| CHEMBL1732 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 15900510 | |||
| CHEMBL1732 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 9225282 | |||
| DB00320 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 15900510 | |||
| DB00320 | 8202 | 21 | None | -83 | 24 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 583 | 4 | 3 | 6 | 2.1 | CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O | 9225282 | |||
| 135398737 | 7745 | 93 | None | -19 | 90 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 38 | 7745 | 93 | None | -19 | 90 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 722 | 7745 | 93 | None | -19 | 90 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| CHEMBL42 | 7745 | 93 | None | -19 | 90 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| DB00363 | 7745 | 93 | None | -19 | 90 | Human | 6.9 | pKi | None | 6.9 | Binding | Guide to Pharmacology | 326 | 0 | 1 | 4 | 3.7 | CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2 | 8935801 | |||
| 102 | 10899 | 48 | None | -100 | 49 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| 3659 | 10899 | 48 | None | -100 | 49 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| 8969 | 10899 | 48 | None | -100 | 49 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| CHEMBL15245 | 10899 | 48 | None | -100 | 49 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| DB01392 | 10899 | 48 | None | -100 | 49 | Human | 7.0 | pKi | None | 7 | Binding | Guide to Pharmacology | 354 | 1 | 2 | 4 | 2.6 | COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1 | 8380639 | |||
| 1342 | 6824 | 49 | None | -21 | 19 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8380639 | |||
| 1342 | 6824 | 49 | None | -21 | 19 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 9225282 | |||
| 3 | 6824 | 49 | None | -21 | 19 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8380639 | |||
| 3 | 6824 | 49 | None | -21 | 19 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 9225282 | |||
| CHEMBL277120 | 6824 | 49 | None | -21 | 19 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 8380639 | |||
| CHEMBL277120 | 6824 | 49 | None | -21 | 19 | Human | 7.3 | pKi | None | 7.3 | Binding | Guide to Pharmacology | 212 | 1 | 1 | 2 | 2.2 | N1CCN(CC1)c1cccc2c1cccc2 | 9225282 | |||
| 145 | 6928 | 49 | None | -7 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 1832 | 6928 | 49 | None | -7 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| CHEMBL7257 | 6928 | 49 | None | -7 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| DB14010 | 6928 | 49 | None | -7 | 30 | Human | 7.4 | pKi | None | 7.4 | Binding | Guide to Pharmacology | 218 | 4 | 1 | 2 | 2.3 | COc1ccc2c(c1)c(CCN(C)C)c[nH]2 | 8380639 | |||
| 2869 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 2869 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 15900510 | |||
| 60 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 60 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 15900510 | |||
| 60857 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| 60857 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 15900510 | |||
| CHEMBL1185 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| CHEMBL1185 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 15900510 | |||
| DB00315 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 10193663 | |||
| DB00315 | 10924 | 89 | None | -25 | 7 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 287 | 5 | 2 | 3 | 1.9 | CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C | 15900510 | |||
| 150 | 9287 | 21 | None | -11 | 16 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| 1764 | 9287 | 21 | None | -11 | 16 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| 8226 | 9287 | 21 | None | -11 | 16 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| CHEMBL1201356 | 9287 | 21 | None | -11 | 16 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| DB00353 | 9287 | 21 | None | -11 | 16 | Human | 7.5 | pKi | None | 7.5 | Binding | Guide to Pharmacology | 339 | 4 | 3 | 3 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO | 8380639 | |||
| 5 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15900510 | |||
| 5 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| 5 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225282 | |||
| 5202 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15900510 | |||
| 5202 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| 5202 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225282 | |||
| CHEMBL39 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15900510 | |||
| CHEMBL39 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| CHEMBL39 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225282 | |||
| DB08839 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 15900510 | |||
| DB08839 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 8380639 | |||
| DB08839 | 6927 | 72 | None | -144 | 53 | Human | 7.9 | pKi | None | 7.9 | Binding | Guide to Pharmacology | 176 | 2 | 3 | 2 | 1.4 | NCCc1c[nH]c2c1cc(O)cc2 | 9225282 | |||
| 134 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15900510 | |||
| 134 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| 1775 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15900510 | |||
| 1775 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| 9681 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15900510 | |||
| 9681 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| CHEMBL1065 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15900510 | |||
| CHEMBL1065 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| DB00247 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 15900510 | |||
| DB00247 | 9292 | 24 | None | -10 | 67 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 353 | 4 | 2 | 4 | 1.9 | CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO | 8380639 | |||
| 1884 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 1884 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 15900510 | |||
| 4440 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 4440 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 15900510 | |||
| 45 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| 45 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 15900510 | |||
| CHEMBL1278 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| CHEMBL1278 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 15900510 | |||
| DB00952 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 10193663 | |||
| DB00952 | 9512 | 58 | None | -3 | 5 | Human | 8.2 | pKi | None | 8.2 | Binding | Guide to Pharmacology | 335 | 5 | 2 | 3 | 2.1 | CNS(=O)(=O)CCc1ccc2c(c1)c(c[nH]2)C1CCN(CC1)C | 15900510 | |||