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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44300265	200122	None	0	Human	Functional	pEC50	=	9.7	9.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	517	9	5	3	3.7	O=C(Cc1ccc(Cl)cc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL57104	200122	None	0	Human	Functional	pEC50	=	9.7	9.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	517	9	5	3	3.7	O=C(Cc1ccc(Cl)cc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	49871766	2557	None	36	Human	Functional	pEC50	=	9.7	9.7	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Human	Functional	pEC50	=	9.7	9.7	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Human	Functional	pEC50	=	9.7	9.7	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	49871766	2557	None	36	Human	Functional	pEC50	=	9.5	9.5	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Human	Functional	pEC50	=	9.5	9.5	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Human	Functional	pEC50	=	9.5	9.5	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	49871766	2557	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Mouse	Functional	pEC50	=	9.4	9.4	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	132427043	195579	None	3	Mouse	Functional	pEC50	=	9.4	9.4	-1	3	Agonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Mouse	Functional	pEC50	=	9.4	9.4	-1	3	Agonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	44300355	198995	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	484	9	5	4	2.4	O=C(Cc1cccnc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL56369	198995	None	0	Human	Functional	pEC50	=	8.9	8.9	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	484	9	5	4	2.4	O=C(Cc1cccnc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	44300451	200543	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	443	9	4	4	3.4	O=C(N/N=C/c1ccco1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL57438	200543	None	0	Human	Functional	pEC50	=	8.8	8.8	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	443	9	4	4	3.4	O=C(N/N=C/c1ccco1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46881642	8098	None	0	Mouse	Functional	pEC50	=	8	8.0	12	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	8	2	2	5.1	CC(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1091468	8098	None	0	Mouse	Functional	pEC50	=	8	8.0	12	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	8	2	2	5.1	CC(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	132427043	195579	None	3	Human	Functional	pEC50	=	8.0	8.0	-2	3	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Human	Functional	pEC50	=	8.0	8.0	-2	3	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46884660	6444	None	0	Human	Functional	pEC50	=	7	7.0	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1082471	6444	None	0	Human	Functional	pEC50	=	7	7.0	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884661	7820	None	0	Human	Functional	pEC50	=	7	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089512	7820	None	0	Human	Functional	pEC50	=	7	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884627	8379	None	0	Human	Functional	pEC50	=	7	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093170	8379	None	0	Human	Functional	pEC50	=	7	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	54580462	60851	None	0	Mouse	Functional	pEC50	=	7	7.0	4	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	422	6	3	5	3.9	CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762251	60851	None	0	Mouse	Functional	pEC50	=	7	7.0	4	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	422	6	3	5	3.9	CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54581475	60873	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human BRS3 by cell-based GRPR assayAgonist activity at human BRS3 by cell-based GRPR assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762275	60873	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human BRS3 by cell-based GRPR assayAgonist activity at human BRS3 by cell-based GRPR assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	54581475	60873	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human BRS3 by cell-based NMBR assayAgonist activity at human BRS3 by cell-based NMBR assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762275	60873	None	0	Human	Functional	pEC50	=	5	5.0	-	1	Agonist activity at human BRS3 by cell-based NMBR assayAgonist activity at human BRS3 by cell-based NMBR assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	4900723	8582	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	377	3	2	6	1.9	CN1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1	10.1016/j.bmcl.2010.03.065
	CHEMBL1094727	8582	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	377	3	2	6	1.9	CN1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1	10.1016/j.bmcl.2010.03.065
	46887826	8583	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	322	3	2	5	2.2	CN(C)c1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2	10.1016/j.bmcl.2010.03.065
	CHEMBL1094728	8583	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	322	3	2	5	2.2	CN(C)c1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2	10.1016/j.bmcl.2010.03.065
	46887767	8587	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	390	3	2	5	3.9	Nc1n[nH]c2nc(N3CCCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1094771	8587	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	390	3	2	5	3.9	Nc1n[nH]c2nc(N3CCCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887768	8588	None	0	Human	Functional	pEC50	=	5	5.0	-11	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	2	5	3.3	CC1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1	10.1016/j.bmcl.2010.03.065
	CHEMBL1094772	8588	None	0	Human	Functional	pEC50	=	5	5.0	-11	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	2	5	3.3	CC1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1	10.1016/j.bmcl.2010.03.065
	46887765	8659	None	0	Human	Functional	pEC50	=	5	5.0	-10	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	348	3	2	5	2.7	Nc1n[nH]c2nc(N3CCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095424	8659	None	0	Human	Functional	pEC50	=	5	5.0	-10	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	348	3	2	5	2.7	Nc1n[nH]c2nc(N3CCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46888066	8674	None	0	Human	Functional	pEC50	=	5	5.0	-21	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	390	5	2	5	3.9	CCNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095528	8674	None	0	Human	Functional	pEC50	=	5	5.0	-21	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	390	5	2	5	3.9	CCNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46888068	8677	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	1	6	3.1	Cn1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095530	8677	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	1	6	3.1	Cn1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3	10.1016/j.bmcl.2010.03.065
	46887766	8697	None	0	Human	Functional	pEC50	=	5	5.0	-6	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	2	5	3.5	Nc1n[nH]c2nc(N3CCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095741	8697	None	0	Human	Functional	pEC50	=	5	5.0	-6	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	2	5	3.5	Nc1n[nH]c2nc(N3CCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887915	8788	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	392	4	2	6	3.1	COc1ccc(CN2CCc3c(c(N4CCCCC4)nc4[nH]nc(N)c34)C2)cc1	10.1016/j.bmcl.2010.03.065
	CHEMBL1096531	8788	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	392	4	2	6	3.1	COc1ccc(CN2CCc3c(c(N4CCCCC4)nc4[nH]nc(N)c34)C2)cc1	10.1016/j.bmcl.2010.03.065
	46887916	8789	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	430	3	2	5	4.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1cccc(C(F)(F)F)c1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1096532	8789	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	430	3	2	5	4.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1cccc(C(F)(F)F)c1)C3	10.1016/j.bmcl.2010.03.065
	46887946	8793	None	0	Human	Functional	pEC50	=	5	5.0	-25	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	406	3	2	7	2.8	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc2c(c1)OCO2)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1096546	8793	None	0	Human	Functional	pEC50	=	5	5.0	-25	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	406	3	2	7	2.8	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc2c(c1)OCO2)C3	10.1016/j.bmcl.2010.03.065
	46887947	8794	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	368	3	2	5	3.5	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CC1CCCCC1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1096547	8794	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	368	3	2	5	3.5	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CC1CCCCC1)C3	10.1016/j.bmcl.2010.03.065
	46887948	8795	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	328	3	2	5	2.5	CC(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1	10.1016/j.bmcl.2010.03.065
	CHEMBL1096548	8795	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	328	3	2	5	2.5	CC(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1	10.1016/j.bmcl.2010.03.065
	46887949	8822	None	0	Human	Functional	pEC50	=	5	5.0	-9	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	342	2	2	5	2.9	CC(C)(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1	10.1016/j.bmcl.2010.03.065
	CHEMBL1096819	8822	None	0	Human	Functional	pEC50	=	5	5.0	-9	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	342	2	2	5	2.9	CC(C)(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1	10.1016/j.bmcl.2010.03.065
	46888069	8885	None	0	Human	Functional	pEC50	=	5	5.0	-13	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	404	3	1	7	3.2	CC(=O)n1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3	10.1016/j.bmcl.2010.03.065
	CHEMBL1097471	8885	None	0	Human	Functional	pEC50	=	5	5.0	-13	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	404	3	1	7	3.2	CC(=O)n1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3	10.1016/j.bmcl.2010.03.065
	46887875	8905	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	336	4	3	5	2.9	CC(C)Nc1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2	10.1016/j.bmcl.2010.03.065
	CHEMBL1097551	8905	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	336	4	3	5	2.9	CC(C)Nc1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2	10.1016/j.bmcl.2010.03.065
	46887824	8955	None	0	Human	Functional	pEC50	=	5	5.0	-20	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	380	3	2	5	3.0	Nc1n[nH]c2nc(N3CCC(F)CC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098097	8955	None	0	Human	Functional	pEC50	=	5	5.0	-20	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	380	3	2	5	3.0	Nc1n[nH]c2nc(N3CCC(F)CC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	3288900	8956	None	5	Human	Functional	pEC50	=	5	5.0	-2	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	364	3	2	6	1.9	Nc1n[nH]c2nc(N3CCOCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098098	8956	None	5	Human	Functional	pEC50	=	5	5.0	-2	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	364	3	2	6	1.9	Nc1n[nH]c2nc(N3CCOCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	25249151	8972	None	3	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	4	3	5	3.8	Nc1n[nH]c2nc(NC3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098185	8972	None	3	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	4	3	5	3.8	Nc1n[nH]c2nc(NC3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	4899895	8973	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	370	4	3	5	3.8	Nc1n[nH]c2nc(Nc3ccccc3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098186	8973	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	370	4	3	5	3.8	Nc1n[nH]c2nc(Nc3ccccc3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887825	9002	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	363	3	3	6	1.5	Nc1n[nH]c2nc(N3CCNCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098433	9002	None	0	Human	Functional	pEC50	=	5	5.0	1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	363	3	3	6	1.5	Nc1n[nH]c2nc(N3CCNCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887950	9031	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	4	2	5	3.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CCc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098535	9031	None	0	Human	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	4	2	5	3.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CCc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887914	14235	None	0	Human	Functional	pEC50	=	5	5.0	-2	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	380	3	2	5	3.2	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc(F)cc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1199153	14235	None	0	Human	Functional	pEC50	=	5	5.0	-2	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	380	3	2	5	3.2	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc(F)cc1)C3	10.1016/j.bmcl.2010.03.065
	4900723	8582	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	377	3	2	6	1.9	CN1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1	10.1016/j.bmcl.2010.03.065
	CHEMBL1094727	8582	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	377	3	2	6	1.9	CN1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1	10.1016/j.bmcl.2010.03.065
	46887767	8587	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	390	3	2	5	3.9	Nc1n[nH]c2nc(N3CCCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1094771	8587	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	390	3	2	5	3.9	Nc1n[nH]c2nc(N3CCCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887915	8788	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	392	4	2	6	3.1	COc1ccc(CN2CCc3c(c(N4CCCCC4)nc4[nH]nc(N)c34)C2)cc1	10.1016/j.bmcl.2010.03.065
	CHEMBL1096531	8788	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	392	4	2	6	3.1	COc1ccc(CN2CCc3c(c(N4CCCCC4)nc4[nH]nc(N)c34)C2)cc1	10.1016/j.bmcl.2010.03.065
	46887916	8789	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	430	3	2	5	4.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1cccc(C(F)(F)F)c1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1096532	8789	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	430	3	2	5	4.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1cccc(C(F)(F)F)c1)C3	10.1016/j.bmcl.2010.03.065
	46887947	8794	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	368	3	2	5	3.5	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CC1CCCCC1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1096547	8794	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	368	3	2	5	3.5	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CC1CCCCC1)C3	10.1016/j.bmcl.2010.03.065
	46887948	8795	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	328	3	2	5	2.5	CC(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1	10.1016/j.bmcl.2010.03.065
	CHEMBL1096548	8795	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	328	3	2	5	2.5	CC(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1	10.1016/j.bmcl.2010.03.065
	25249151	8972	None	3	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	4	3	5	3.8	Nc1n[nH]c2nc(NC3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098185	8972	None	3	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	4	3	5	3.8	Nc1n[nH]c2nc(NC3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	4899895	8973	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	370	4	3	5	3.8	Nc1n[nH]c2nc(Nc3ccccc3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098186	8973	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	370	4	3	5	3.8	Nc1n[nH]c2nc(Nc3ccccc3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887825	9002	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	363	3	3	6	1.5	Nc1n[nH]c2nc(N3CCNCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098433	9002	None	0	Rat	Functional	pEC50	=	5	5.0	-1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	363	3	3	6	1.5	Nc1n[nH]c2nc(N3CCNCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46882060	6315	None	0	Mouse	Functional	pEC50	=	5	5.0	-2	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	346	7	2	2	5.3	CCCCc1cnc(/C=C/c2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1081866	6315	None	0	Mouse	Functional	pEC50	=	5	5.0	-2	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	346	7	2	2	5.3	CCCCc1cnc(/C=C/c2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46881560	6994	None	0	Human	Functional	pEC50	=	6	6.0	-13	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	346	7	2	2	4.5	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084697	6994	None	0	Human	Functional	pEC50	=	6	6.0	-13	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	346	7	2	2	4.5	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46845425	1032	None	2	Human	Functional	pEC50	=	7	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	8504	1032	None	2	Human	Functional	pEC50	=	7	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1089721	1032	None	2	Human	Functional	pEC50	=	7	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	172446140	195510	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	529	7	2	9	4.9	C=CC(C)(C)C(OC(=O)c1cccnc1Br)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5405083	195510	None	0	Human	Functional	pEC50	=	7.0	7.0	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	529	7	2	9	4.9	C=CC(C)(C)C(OC(=O)c1cccnc1Br)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	25026056	8183	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091985	8183	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884630	8422	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093459	8422	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	62707362	81903	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-14	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	541	3	1	6	6.3	Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1	10.1021/ml200304j
	CHEMBL2164577	81903	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-14	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	541	3	1	6	6.3	Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1	10.1021/ml200304j
	46881509	7603	None	0	Mouse	Functional	pEC50	=	7.0	7.0	22	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(Cl)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1087933	7603	None	0	Mouse	Functional	pEC50	=	7.0	7.0	22	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(Cl)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46885311	8317	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092730	8317	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	46884576	8113	None	0	Mouse	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091598	8113	None	0	Mouse	Functional	pEC50	=	7.0	7.0	4	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	46884578	8182	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091984	8182	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884630	8422	None	0	Mouse	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093459	8422	None	0	Mouse	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884659	7819	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089511	7819	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25026056	8183	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091985	8183	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25025861	8382	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093184	8382	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46887949	8822	None	0	Rat	Functional	pEC50	=	6.0	6.0	9	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	342	2	2	5	2.9	CC(C)(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1	10.1016/j.bmcl.2010.03.065
	CHEMBL1096819	8822	None	0	Rat	Functional	pEC50	=	6.0	6.0	9	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	342	2	2	5	2.9	CC(C)(C)CN1CCc2c(c(N3CCCCC3)nc3[nH]nc(N)c23)C1	10.1016/j.bmcl.2010.03.065
	25025862	7823	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089521	7823	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25026056	8183	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091985	8183	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25025858	7784	None	0	Human	Functional	pEC50	=	7.0	7.0	-16	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	6	2	2	5.1	CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1089383	7784	None	0	Human	Functional	pEC50	=	7.0	7.0	-16	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	6	2	2	5.1	CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46884661	7820	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089512	7820	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884688	8175	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091918	8175	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618681	82820	None	0	Human	Functional	pEC50	=	7.0	7.0	14	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	512	2	1	5	6.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1	10.1021/ml200207w
	CHEMBL2179918	82820	None	0	Human	Functional	pEC50	=	7.0	7.0	14	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	512	2	1	5	6.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1	10.1021/ml200207w
	46884659	7819	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089511	7819	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884659	7819	None	0	Mouse	Functional	pEC50	=	8.0	8.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089511	7819	None	0	Mouse	Functional	pEC50	=	8.0	8.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884661	7820	None	0	Mouse	Functional	pEC50	=	8.0	8.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089512	7820	None	0	Mouse	Functional	pEC50	=	8.0	8.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884627	8379	None	0	Mouse	Functional	pEC50	=	8.0	8.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093170	8379	None	0	Mouse	Functional	pEC50	=	8.0	8.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889210	7534	None	0	Mouse	Functional	pEC50	=	8.0	8.0	1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	387	6	2	2	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087443	7534	None	0	Mouse	Functional	pEC50	=	8.0	8.0	1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	387	6	2	2	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	46881416	7167	None	0	Mouse	Functional	pEC50	=	8.0	8.0	18	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	382	7	2	2	5.2	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1085434	7167	None	0	Mouse	Functional	pEC50	=	8.0	8.0	18	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	382	7	2	2	5.2	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	59618811	82816	None	0	Human	Functional	pEC50	=	7.0	7.0	6	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	461	2	1	4	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1021/ml200207w
	CHEMBL2179914	82816	None	0	Human	Functional	pEC50	=	7.0	7.0	6	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	461	2	1	4	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1021/ml200207w
	59618620	82819	None	0	Human	Functional	pEC50	=	7.0	7.0	7	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	476	2	1	5	5.6	Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179917	82819	None	0	Human	Functional	pEC50	=	7.0	7.0	7	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	476	2	1	5	5.6	Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	54584418	60849	None	0	Mouse	Functional	pEC50	=	7.0	7.0	6	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762249	60849	None	0	Mouse	Functional	pEC50	=	7.0	7.0	6	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	46884663	7825	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089523	7825	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25025862	7823	None	0	Mouse	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089521	7823	None	0	Mouse	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	62707363	81904	None	0	Human	Functional	pEC50	=	6.9	6.9	8	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	544	3	2	5	6.3	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1	10.1021/ml200304j
	CHEMBL2164578	81904	None	0	Human	Functional	pEC50	=	6.9	6.9	8	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	544	3	2	5	6.3	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1	10.1021/ml200304j
	46884629	8381	None	0	Mouse	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093183	8381	None	0	Mouse	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	62707363	81904	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-8	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	544	3	2	5	6.3	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1	10.1021/ml200304j
	CHEMBL2164578	81904	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-8	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	544	3	2	5	6.3	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1	10.1021/ml200304j
	46882013	5607	None	0	Human	Functional	pEC50	=	5.9	5.9	-7	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	10	2	2	6.2	CCCCc1cnc(C(CCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1077345	5607	None	0	Human	Functional	pEC50	=	5.9	5.9	-7	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	10	2	2	6.2	CCCCc1cnc(C(CCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46884660	6444	None	0	Mouse	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1082471	6444	None	0	Mouse	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884628	8255	None	0	Mouse	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092381	8255	None	0	Mouse	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46881642	8098	None	0	Human	Functional	pEC50	=	6.9	6.9	-12	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	8	2	2	5.1	CC(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1091468	8098	None	0	Human	Functional	pEC50	=	6.9	6.9	-12	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	8	2	2	5.1	CC(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46884662	7824	None	0	Mouse	Functional	pEC50	=	7.9	7.9	6	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089522	7824	None	0	Mouse	Functional	pEC50	=	7.9	7.9	6	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889177	7486	None	0	Mouse	Functional	pEC50	=	7.9	7.9	10	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	497	10	2	4	6.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087066	7486	None	0	Mouse	Functional	pEC50	=	7.9	7.9	10	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	497	10	2	4	6.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46889233	7659	None	0	Mouse	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	383	8	2	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088409	7659	None	0	Mouse	Functional	pEC50	=	7.9	7.9	-1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	383	8	2	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	66901749	82813	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-18	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	2	1	4	6.2	Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179911	82813	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-18	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	2	1	4	6.2	Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	54585379	60859	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762261	60859	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54583454	60871	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762273	60871	None	0	Human	Functional	pEC50	=	5.9	5.9	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	90663970	106847	None	0	Human	Functional	pEC50	=	5.9	5.9	12	3	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	553	14	5	4	2.5	NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144503	106847	None	0	Human	Functional	pEC50	=	5.9	5.9	12	3	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	553	14	5	4	2.5	NC(=O)CC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46884662	7824	None	0	Mouse	Functional	pEC50	=	6.9	6.9	6	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089522	7824	None	0	Mouse	Functional	pEC50	=	6.9	6.9	6	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618658	82698	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179481	82698	None	0	Human	Functional	pEC50	=	6.9	6.9	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46887981	9092	None	0	Rat	Functional	pEC50	=	6.9	6.9	28	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	418	5	2	5	3.9	CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1099123	9092	None	0	Rat	Functional	pEC50	=	6.9	6.9	28	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	418	5	2	5	3.9	CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46888018	9064	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	460	5	2	5	4.9	CC(C)(C)CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098837	9064	None	0	Human	Functional	pEC50	=	5.9	5.9	-2	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	460	5	2	5	4.9	CC(C)(C)CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46885312	8103	None	0	Human	Functional	pEC50	=	5.9	5.9	-10	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091553	8103	None	0	Human	Functional	pEC50	=	5.9	5.9	-10	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	46881471	6463	None	0	Human	Functional	pEC50	=	6.9	6.9	-13	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1082543	6463	None	0	Human	Functional	pEC50	=	6.9	6.9	-13	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46889177	7486	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	497	10	2	4	6.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087066	7486	None	0	Human	Functional	pEC50	=	6.9	6.9	-10	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	497	10	2	4	6.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	59618681	82820	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-14	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	512	2	1	5	6.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1	10.1021/ml200207w
	CHEMBL2179918	82820	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-14	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	512	2	1	5	6.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1	10.1021/ml200207w
	46887980	9091	None	0	Rat	Functional	pEC50	=	6.9	6.9	24	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	404	4	2	5	3.5	CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1099122	9091	None	0	Rat	Functional	pEC50	=	6.9	6.9	24	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	404	4	2	5	3.5	CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46889235	7661	None	0	Mouse	Functional	pEC50	=	7.9	7.9	2	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	406	8	2	4	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088411	7661	None	0	Mouse	Functional	pEC50	=	7.9	7.9	2	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	406	8	2	4	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	25026058	7671	None	0	Mouse	Functional	pEC50	=	7.9	7.9	2	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	377	7	2	3	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088553	7671	None	0	Mouse	Functional	pEC50	=	7.9	7.9	2	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	377	7	2	3	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1	10.1016/j.bmcl.2010.03.028
	54580461	60850	None	0	Mouse	Functional	pEC50	=	7.9	7.9	4	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	380	6	3	5	2.9	CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762250	60850	None	0	Mouse	Functional	pEC50	=	7.9	7.9	4	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	380	6	3	5	2.9	CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	49871766	2557	None	36	Mouse	Functional	pEC50	=	7.9	7.9	-3	5	Agonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Mouse	Functional	pEC50	=	7.9	7.9	-3	5	Agonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Mouse	Functional	pEC50	=	7.9	7.9	-3	5	Agonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at endogenous mouse BB3 in mouse B16 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	46200989	2562	None	14	Mouse	Functional	pEC50	=	6.9	6.9	-9	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1021/ml200304j
	8502	2562	None	14	Mouse	Functional	pEC50	=	6.9	6.9	-9	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1021/ml200304j
	CHEMBL2023109	2562	None	14	Mouse	Functional	pEC50	=	6.9	6.9	-9	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1021/ml200304j
	46200989	2562	None	14	Mouse	Functional	pEC50	=	6.9	6.9	-9	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	8502	2562	None	14	Mouse	Functional	pEC50	=	6.9	6.9	-9	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	CHEMBL2023109	2562	None	14	Mouse	Functional	pEC50	=	6.9	6.9	-9	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	54583450	60858	None	0	Mouse	Functional	pEC50	=	5.9	5.9	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	388	4	3	5	3.0	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21	10.1016/j.bmcl.2011.02.011
	CHEMBL1762259	60858	None	0	Mouse	Functional	pEC50	=	5.9	5.9	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	388	4	3	5	3.0	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21	10.1016/j.bmcl.2011.02.011
	46884577	8114	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091599	8114	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618635	82700	None	0	Human	Functional	pEC50	=	6.9	6.9	6	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	435	2	1	4	5.8	Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2	10.1021/ml200207w
	CHEMBL2179484	82700	None	0	Human	Functional	pEC50	=	6.9	6.9	6	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	435	2	1	4	5.8	Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2	10.1021/ml200207w
	46881417	7219	None	0	Human	Functional	pEC50	=	5.9	5.9	-7	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	8	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCc3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1085670	7219	None	0	Human	Functional	pEC50	=	5.9	5.9	-7	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	8	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCc3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46889146	7685	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	348	7	2	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088684	7685	None	0	Human	Functional	pEC50	=	6.9	6.9	-1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	348	7	2	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1	10.1016/j.bmcl.2010.03.028
	46884688	8175	None	0	Mouse	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091918	8175	None	0	Mouse	Functional	pEC50	=	6.9	6.9	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25025654	570	None	12	Human	Functional	pEC50	=	6.9	6.9	-15	3	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	10.1016/j.bmcl.2010.01.154
	6189	570	None	12	Human	Functional	pEC50	=	6.9	6.9	-15	3	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	10.1016/j.bmcl.2010.01.154
	8506	570	None	12	Human	Functional	pEC50	=	6.9	6.9	-15	3	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084942	570	None	12	Human	Functional	pEC50	=	6.9	6.9	-15	3	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	10.1016/j.bmcl.2010.01.154
	62707528	81818	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-11	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	4	2	8	6.0	C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164222	81818	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-11	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	4	2	8	6.0	C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	71451990	82817	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-6	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	537	3	2	5	6.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1	10.1021/ml200207w
	CHEMBL2179915	82817	None	0	Mouse	Functional	pEC50	=	6.9	6.9	-6	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	537	3	2	5	6.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1	10.1021/ml200207w
	172444284	195042	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	7	2	9	3.6	C=CC(C)(C)C(OC(=O)C1CCCO1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5395420	195042	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	444	7	2	9	3.6	C=CC(C)(C)C(OC(=O)C1CCCO1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	25025862	7823	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089521	7823	None	0	Human	Functional	pEC50	=	6.9	6.9	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	49871766	2557	None	36	Human	Functional	pEC50	=	7.9	7.9	-6	5	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Human	Functional	pEC50	=	7.9	7.9	-6	5	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Human	Functional	pEC50	=	7.9	7.9	-6	5	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	25026044	57859	None	1	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	390	6	2	4	3.9	CC(O)(Cc1nc(CC2(C(F)(F)F)CC2)c[nH]1)c1ccc(-n2cccn2)cc1	10.1021/ml100196d
	CHEMBL1671874	57859	None	1	Human	Functional	pEC50	=	7.9	7.9	-	1	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	390	6	2	4	3.9	CC(O)(Cc1nc(CC2(C(F)(F)F)CC2)c[nH]1)c1ccc(-n2cccn2)cc1	10.1021/ml100196d
	46885312	8103	None	0	Mouse	Functional	pEC50	=	7.9	7.9	10	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091553	8103	None	0	Mouse	Functional	pEC50	=	7.9	7.9	10	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	172443644	195475	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	451	7	2	9	4.1	C=CC(C)(C)C(OC(=O)c1ccccn1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5404444	195475	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	451	7	2	9	4.1	C=CC(C)(C)C(OC(=O)c1ccccn1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46881604	8872	None	0	Mouse	Functional	pEC50	=	7.8	7.8	25	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	6	2	2	5.6	O=C(O)c1ccccc1-c1ccc(CCc2ncc(C3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1097362	8872	None	0	Mouse	Functional	pEC50	=	7.8	7.8	25	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	6	2	2	5.6	O=C(O)c1ccccc1-c1ccc(CCc2ncc(C3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	90663956	106833	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	530	11	4	3	4.0	C[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144489	106833	None	0	Human	Functional	pEC50	=	6.9	6.9	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	530	11	4	3	4.0	C[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	90663965	106842	None	0	Human	Functional	pEC50	=	5.9	5.9	8	3	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	587	14	5	4	3.2	NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144498	106842	None	0	Human	Functional	pEC50	=	5.9	5.9	8	3	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	587	14	5	4	3.2	NC(=O)CC[C@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	4594	42886	None	68	Human	Functional	pEC50	=	4.9	4.9	-4	6	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1016/j.bmcl.2008.09.033
	CHEMBL1503	42886	None	68	Human	Functional	pEC50	=	4.9	4.9	-4	6	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	345	5	1	5	2.9	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1	10.1016/j.bmcl.2008.09.033
	46887766	8697	None	0	Rat	Functional	pEC50	=	5.8	5.8	6	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	2	5	3.5	Nc1n[nH]c2nc(N3CCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095741	8697	None	0	Rat	Functional	pEC50	=	5.8	5.8	6	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	2	5	3.5	Nc1n[nH]c2nc(N3CCCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	25134007	81820	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-87	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	5	2	8	6.0	CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	CHEMBL2164224	81820	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-87	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	5	2	8	6.0	CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	59618675	82696	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	497	1	1	5	4.8	Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179479	82696	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	497	1	1	5	4.8	Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	132427043	195579	None	3	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonist activity at human BB3 transiently expressed in human HEK293T cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 transiently expressed in human HEK293T cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Human	Functional	pEC50	=	6.8	6.8	-2	3	Agonist activity at human BB3 transiently expressed in human HEK293T cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 transiently expressed in human HEK293T cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46885313	8104	None	0	Human	Functional	pEC50	=	7.8	7.8	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091554	8104	None	0	Human	Functional	pEC50	=	7.8	7.8	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889234	7660	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	407	8	2	5	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088410	7660	None	0	Human	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	407	8	2	5	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	56840673	1141	None	0	Human	Functional	pEC50	=	7.8	7.8	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 10 mins by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 10 mins by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	8503	1141	None	0	Human	Functional	pEC50	=	7.8	7.8	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 10 mins by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 10 mins by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	CHEMBL2164575	1141	None	0	Human	Functional	pEC50	=	7.8	7.8	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 10 mins by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 10 mins by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	59618711	74220	None	0	Human	Functional	pEC50	=	7.8	7.8	3	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	600	5	2	6	5.6	CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	CHEMBL2023114	74220	None	0	Human	Functional	pEC50	=	7.8	7.8	3	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	600	5	2	6	5.6	CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	46884578	8182	None	0	Mouse	Functional	pEC50	=	7.8	7.8	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091984	8182	None	0	Mouse	Functional	pEC50	=	7.8	7.8	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	44300408	199260	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	455	10	5	3	3.4	O=C(NNCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL56562	199260	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	455	10	5	3	3.4	O=C(NNCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	172460636	196513	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	451	7	2	9	4.1	C=CC(C)(C)C(OC(=O)c1cccnc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5425677	196513	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	451	7	2	9	4.1	C=CC(C)(C)C(OC(=O)c1cccnc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	44300286	96612	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	1106	31	11	12	2.1	CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O	10.1021/jm0210921
	CHEMBL262992	96612	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	3	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	1106	31	11	12	2.1	CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CCNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)O	10.1021/jm0210921
	59618623	82691	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	501	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179474	82691	None	0	Human	Functional	pEC50	=	6.8	6.8	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	501	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	59618785	82697	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179480	82697	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46888017	9063	None	0	Human	Functional	pEC50	=	5.8	5.8	-24	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	446	4	2	5	4.5	CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098836	9063	None	0	Human	Functional	pEC50	=	5.8	5.8	-24	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	446	4	2	5	4.5	CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	66901760	82814	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-10	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	495	2	1	4	6.5	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1	10.1021/ml200207w
	CHEMBL2179912	82814	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-10	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	495	2	1	4	6.5	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1	10.1021/ml200207w
	59618785	82697	None	0	Human	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179480	82697	None	0	Human	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46881473	7678	None	0	Human	Functional	pEC50	=	6.8	6.8	-19	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1088614	7678	None	0	Human	Functional	pEC50	=	6.8	6.8	-19	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	25026446	57963	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	338	5	2	4	3.6	CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-n3cccn3)cc2)n1	10.1021/ml100196d
	CHEMBL1672353	57963	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	338	5	2	4	3.6	CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-n3cccn3)cc2)n1	10.1021/ml100196d
	25025861	8382	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093184	8382	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889234	7660	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	407	8	2	5	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088410	7660	None	0	Mouse	Functional	pEC50	=	7.8	7.8	-1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	407	8	2	5	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46889145	9078	None	0	Mouse	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	398	7	2	4	4.8	c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1	10.1016/j.bmcl.2010.03.028
	CHEMBL1099034	9078	None	0	Mouse	Functional	pEC50	=	7.8	7.8	1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	398	7	2	4	4.8	c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1	10.1016/j.bmcl.2010.03.028
	54581470	60848	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762248	60848	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54583452	60867	None	0	Mouse	Functional	pEC50	=	6.8	6.8	7	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	399	5	2	4	4.8	CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762269	60867	None	0	Mouse	Functional	pEC50	=	6.8	6.8	7	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	399	5	2	4	4.8	CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1	10.1016/j.bmcl.2011.02.011
	54586337	60860	None	0	Human	Functional	pEC50	=	5.8	5.8	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762262	60860	None	0	Human	Functional	pEC50	=	5.8	5.8	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	44589824	186797	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	330	6	1	5	3.9	COc1cc(CSc2nc3ccc(OC)cc3[nH]2)cc(OC)c1	10.1016/j.bmcl.2008.09.033
	CHEMBL488400	186797	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	330	6	1	5	3.9	COc1cc(CSc2nc3ccc(OC)cc3[nH]2)cc(OC)c1	10.1016/j.bmcl.2008.09.033
	46881558	7335	None	0	Human	Functional	pEC50	=	5.8	5.8	-31	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(F)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1086177	7335	None	0	Human	Functional	pEC50	=	5.8	5.8	-31	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(F)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	59618811	82816	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-6	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	461	2	1	4	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1021/ml200207w
	CHEMBL2179914	82816	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-6	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	461	2	1	4	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1021/ml200207w
	46881507	7467	None	0	Mouse	Functional	pEC50	=	6.8	6.8	16	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1086912	7467	None	0	Mouse	Functional	pEC50	=	6.8	6.8	16	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46881418	6764	None	0	Mouse	Functional	pEC50	=	6.8	6.8	10	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1083825	6764	None	0	Mouse	Functional	pEC50	=	6.8	6.8	10	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46882013	5607	None	0	Mouse	Functional	pEC50	=	6.8	6.8	7	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	10	2	2	6.2	CCCCc1cnc(C(CCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1077345	5607	None	0	Mouse	Functional	pEC50	=	6.8	6.8	7	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	10	2	2	6.2	CCCCc1cnc(C(CCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46884627	8379	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093170	8379	None	0	Human	Functional	pEC50	=	6.8	6.8	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	44300427	200071	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	468	12	4	3	3.4	O=C(CNCCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL57068	200071	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	468	12	4	3	3.4	O=C(CNCCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	54583454	60871	None	0	Mouse	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762273	60871	None	0	Mouse	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54586335	60854	None	0	Human	Functional	pEC50	=	5.8	5.8	-12	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762254	60854	None	0	Human	Functional	pEC50	=	5.8	5.8	-12	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	54582478	60872	None	0	Human	Functional	pEC50	=	5.8	5.8	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762274	60872	None	0	Human	Functional	pEC50	=	5.8	5.8	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	46884688	8175	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091918	8175	None	0	Human	Functional	pEC50	=	6.8	6.8	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618620	82819	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-7	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	476	2	1	5	5.6	Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179917	82819	None	0	Mouse	Functional	pEC50	=	6.8	6.8	-7	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	476	2	1	5	5.6	Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46889175	7443	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	429	10	2	4	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086673	7443	None	0	Human	Functional	pEC50	=	6.8	6.8	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	429	10	2	4	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46881418	6764	None	0	Human	Functional	pEC50	=	5.8	5.8	-10	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1083825	6764	None	0	Human	Functional	pEC50	=	5.8	5.8	-10	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46881417	7219	None	0	Mouse	Functional	pEC50	=	6.8	6.8	7	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	8	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCc3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1085670	7219	None	0	Mouse	Functional	pEC50	=	6.8	6.8	7	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	8	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCc3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46882011	5893	None	0	Rat	Functional	pEC50	=	6.8	6.8	1	3	Agonistic activity at rat BRS3 expressed in HEK293AEO at 10 uM by aequorin bioluminescence assayAgonistic activity at rat BRS3 expressed in HEK293AEO at 10 uM by aequorin bioluminescence assay	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079517	5893	None	0	Rat	Functional	pEC50	=	6.8	6.8	1	3	Agonistic activity at rat BRS3 expressed in HEK293AEO at 10 uM by aequorin bioluminescence assayAgonistic activity at rat BRS3 expressed in HEK293AEO at 10 uM by aequorin bioluminescence assay	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46889147	7686	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	445	7	1	5	5.7	O=C1NC(=O)C(c2ccccc2-c2ccc(CCC3N=CC(CC4CCCC4)=N3)cc2)S1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088685	7686	None	0	Human	Functional	pEC50	=	5.8	5.8	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	445	7	1	5	5.7	O=C1NC(=O)C(c2ccccc2-c2ccc(CCC3N=CC(CC4CCCC4)=N3)cc2)S1	10.1016/j.bmcl.2010.03.028
	46881510	7616	None	0	Human	Functional	pEC50	=	6.8	6.8	-18	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3F)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1088062	7616	None	0	Human	Functional	pEC50	=	6.8	6.8	-18	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3F)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	54585380	60864	None	0	Mouse	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	380	4	2	5	2.8	CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762266	60864	None	0	Mouse	Functional	pEC50	=	6.8	6.8	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	380	4	2	5	2.8	CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C	10.1016/j.bmcl.2011.02.011
	46881921	8059	None	0	Mouse	Functional	pEC50	=	6.7	6.7	15	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	8	2	2	5.5	CCCCc1cnc(C(C)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1091087	8059	None	0	Mouse	Functional	pEC50	=	6.7	6.7	15	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	8	2	2	5.5	CCCCc1cnc(C(C)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46882011	5893	None	0	Human	Functional	pEC50	=	5.7	5.7	-15	3	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079517	5893	None	0	Human	Functional	pEC50	=	5.7	5.7	-15	3	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	25026056	8183	None	0	Mouse	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091985	8183	None	0	Mouse	Functional	pEC50	=	7.7	7.7	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	44387452	60529	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	538	9	6	4	3.0	O=C(CC1NCCc2ccccc21)NNC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL175651	60529	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	538	9	6	4	3.0	O=C(CC1NCCc2ccccc21)NNC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	54582478	60872	None	0	Mouse	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762274	60872	None	0	Mouse	Functional	pEC50	=	6.7	6.7	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	46882011	5893	None	0	Human	Functional	pEC50	=	5.7	5.7	-15	3	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1021/ml100196d
	CHEMBL1079517	5893	None	0	Human	Functional	pEC50	=	5.7	5.7	-15	3	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1021/ml100196d
	46884629	8381	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093183	8381	None	0	Human	Functional	pEC50	=	6.7	6.7	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	71460964	82815	None	0	Human	Functional	pEC50	=	6.7	6.7	11	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	2	1	4	6.2	Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179913	82815	None	0	Human	Functional	pEC50	=	6.7	6.7	11	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	2	1	4	6.2	Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	90663968	106845	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	496	11	4	3	3.3	C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144501	106845	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	496	11	4	3	3.3	C[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	49871766	2557	None	36	Rat	Functional	pEC50	=	8.7	8.7	3	5	Agonist activity at rat BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at rat BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Rat	Functional	pEC50	=	8.7	8.7	3	5	Agonist activity at rat BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at rat BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Rat	Functional	pEC50	=	8.7	8.7	3	5	Agonist activity at rat BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at rat BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	44300379	101100	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	522	9	6	3	3.5	O=C(Cc1cc2ccccc2[nH]1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL294647	101100	None	0	Human	Functional	pEC50	=	8.7	8.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	522	9	6	3	3.5	O=C(Cc1cc2ccccc2[nH]1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	25025860	569	None	23	Mouse	Functional	pEC50	=	8.6	8.6	-4	5	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	6188	569	None	23	Mouse	Functional	pEC50	=	8.6	8.6	-4	5	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1091720	569	None	23	Mouse	Functional	pEC50	=	8.6	8.6	-4	5	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	25025863	8501	None	0	Mouse	Functional	pEC50	=	8.5	8.5	4	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	430	10	2	5	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1094054	8501	None	0	Mouse	Functional	pEC50	=	8.5	8.5	4	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	430	10	2	5	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	44300436	200025	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	488	11	4	3	4.0	O=C(CNCc1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL57039	200025	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	488	11	4	3	4.0	O=C(CNCc1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	49871766	2557	None	36	Mouse	Functional	pEC50	=	8.5	8.5	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Mouse	Functional	pEC50	=	8.5	8.5	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Mouse	Functional	pEC50	=	8.5	8.5	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	46881470	6462	None	0	Mouse	Functional	pEC50	=	7.7	7.7	40	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	CHEMBL1082542	6462	None	0	Mouse	Functional	pEC50	=	7.7	7.7	40	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	54582477	60868	None	0	Mouse	Functional	pEC50	=	6.7	6.7	11	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	406	5	2	6	4.2	CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762270	60868	None	0	Mouse	Functional	pEC50	=	6.7	6.7	11	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	406	5	2	6	4.2	CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	71460937	82694	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-10	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	493	3	1	4	6.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179477	82694	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-10	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	493	3	1	4	6.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46881416	7167	None	0	Human	Functional	pEC50	=	6.7	6.7	-18	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	382	7	2	2	5.2	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1085434	7167	None	0	Human	Functional	pEC50	=	6.7	6.7	-18	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	382	7	2	2	5.2	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	71451991	82818	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-15	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	477	2	2	5	5.6	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1	10.1021/ml200207w
	CHEMBL2179916	82818	None	0	Mouse	Functional	pEC50	=	6.7	6.7	-15	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	477	2	2	5	5.6	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1	10.1021/ml200207w
	59618746	74219	None	0	Human	Functional	pEC50	=	7.7	7.7	6	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	586	5	2	6	5.4	NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	CHEMBL2023113	74219	None	0	Human	Functional	pEC50	=	7.7	7.7	6	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	586	5	2	6	5.4	NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	49871766	2557	None	36	Mouse	Functional	pEC50	=	7.7	7.7	-3	5	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Mouse	Functional	pEC50	=	7.7	7.7	-3	5	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Mouse	Functional	pEC50	=	7.7	7.7	-3	5	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	53242205	60847	None	0	Mouse	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762247	60847	None	0	Mouse	Functional	pEC50	=	7.7	7.7	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	44300429	100702	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	455	11	4	4	2.7	O=C(CNCc1cccnc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL292176	100702	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	455	11	4	4	2.7	O=C(CNCc1cccnc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	44300505	163225	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	454	11	4	3	3.3	O=C(CNCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL417767	163225	None	0	Human	Functional	pEC50	=	7.7	7.7	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	454	11	4	3	3.3	O=C(CNCc1ccccc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	44589872	172826	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	330	4	1	4	3.7	COc1ccc2nc(CCc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	CHEMBL450593	172826	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	330	4	1	4	3.7	COc1ccc2nc(CCc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	54582477	60868	None	0	Human	Functional	pEC50	=	5.7	5.7	-11	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	406	5	2	6	4.2	CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762270	60868	None	0	Human	Functional	pEC50	=	5.7	5.7	-11	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	406	5	2	6	4.2	CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	46888020	9098	None	0	Rat	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	460	6	2	5	4.9	CCC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1099135	9098	None	0	Rat	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	460	6	2	5	4.9	CCC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	59618675	82696	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	497	1	1	5	4.8	Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179479	82696	None	0	Human	Functional	pEC50	=	6.7	6.7	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	497	1	1	5	4.8	Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46884576	8113	None	0	Mouse	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091598	8113	None	0	Mouse	Functional	pEC50	=	7.7	7.7	4	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	59618746	74219	None	0	Mouse	Functional	pEC50	=	7.7	7.7	-6	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	586	5	2	6	5.4	NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	CHEMBL2023113	74219	None	0	Mouse	Functional	pEC50	=	7.7	7.7	-6	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	586	5	2	6	5.4	NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	59618711	74220	None	0	Mouse	Functional	pEC50	=	7.7	7.7	-3	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	600	5	2	6	5.6	CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	CHEMBL2023114	74220	None	0	Mouse	Functional	pEC50	=	7.7	7.7	-3	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	600	5	2	6	5.6	CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	46882010	6064	None	0	Mouse	Functional	pEC50	=	7.7	7.7	13	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3Cl)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1080581	6064	None	0	Mouse	Functional	pEC50	=	7.7	7.7	13	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3Cl)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	25055504	57961	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	367	5	2	3	4.7	CC(C)(C)Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	CHEMBL1672351	57961	None	0	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	367	5	2	3	4.7	CC(C)(C)Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	54581471	60852	None	0	Human	Functional	pEC50	=	6.7	6.7	-6	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	444	5	3	5	3.6	O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762252	60852	None	0	Human	Functional	pEC50	=	6.7	6.7	-6	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	444	5	3	5	3.6	O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	4157547	25237	None	9	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human BRS3 expressed in HEK293AEQ cells using 10 uM dy-peptide by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells using 10 uM dy-peptide by bioluminescence assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1348293	25237	None	9	Human	Functional	pEC50	=	6.7	6.7	-	1	Agonist activity at human BRS3 expressed in HEK293AEQ cells using 10 uM dy-peptide by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells using 10 uM dy-peptide by bioluminescence assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	46882057	5924	None	0	Mouse	Functional	pEC50	=	5.7	5.7	2	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	9	2	2	6.1	CCCCc1cnc(C(Cc2ccc(-c3ccccc3C(=O)O)cc2)C(C)C)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079696	5924	None	0	Mouse	Functional	pEC50	=	5.7	5.7	2	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	9	2	2	6.1	CCCCc1cnc(C(Cc2ccc(-c3ccccc3C(=O)O)cc2)C(C)C)[nH]1	10.1016/j.bmcl.2010.01.154
	135398391	195996	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	418	10	3	8	3.7	C=CC(C)(C)C(OCCCCO)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5414856	195996	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	418	10	3	8	3.7	C=CC(C)(C)C(OCCCCO)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46881509	7603	None	0	Human	Functional	pEC50	=	5.6	5.6	-22	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(Cl)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1087933	7603	None	0	Human	Functional	pEC50	=	5.6	5.6	-22	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(Cl)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46881605	8873	None	0	Mouse	Functional	pEC50	=	7.6	7.6	14	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	7	2	3	4.5	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1097363	8873	None	0	Mouse	Functional	pEC50	=	7.6	7.6	14	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	7	2	3	4.5	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	90663969	106846	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	601	15	5	4	3.6	NC(=O)CC[C@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144502	106846	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	601	15	5	4	3.6	NC(=O)CC[C@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	59618635	82700	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-6	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	435	2	1	4	5.8	Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2	10.1021/ml200207w
	CHEMBL2179484	82700	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-6	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	435	2	1	4	5.8	Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2	10.1021/ml200207w
	46882011	5893	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-1	3	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079517	5893	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-1	3	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	123695309	196718	None	0	Human	Functional	pEC50	=	5.6	5.6	-4	2	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5430646	196718	None	0	Human	Functional	pEC50	=	5.6	5.6	-4	2	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46889233	7659	None	0	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	383	8	2	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088409	7659	None	0	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	383	8	2	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	44300796	163282	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	445	10	5	4	3.0	O=C(NNCc1ccco1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL418147	163282	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	445	10	5	4	3.0	O=C(NNCc1ccco1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	44589929	189544	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	370	3	1	4	4.5	FC(F)(F)c1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	CHEMBL513374	189544	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	370	3	1	4	4.5	FC(F)(F)c1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	65909	39640	None	17	Human	Functional	pEC50	=	6.6	6.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	428	3	1	5	4.2	CC1(CN2CCC(n3c(=O)[nH]c4ccccc43)CC2)OCc2ccccc2-n2cccc21	10.1021/jm0210921
	CHEMBL1474352	39640	None	17	Human	Functional	pEC50	=	6.6	6.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	428	3	1	5	4.2	CC1(CN2CCC(n3c(=O)[nH]c4ccccc43)CC2)OCc2ccccc2-n2cccc21	10.1021/jm0210921
	CHEMBL5483013	39640	None	17	Human	Functional	pEC50	=	6.6	6.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	428	3	1	5	4.2	CC1(CN2CCC(n3c(=O)[nH]c4ccccc43)CC2)OCc2ccccc2-n2cccc21	10.1021/jm0210921
	59618646	82699	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	421	2	1	4	5.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2	10.1021/ml200207w
	CHEMBL2179482	82699	None	0	Mouse	Functional	pEC50	=	6.6	6.6	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	421	2	1	4	5.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2	10.1021/ml200207w
	46845425	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	8504	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1089721	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	46845425	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	8504	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	CHEMBL1089721	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	46884687	8174	None	0	Mouse	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091917	8174	None	0	Mouse	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46845425	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.01.154
	8504	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.01.154
	CHEMBL1089721	1032	None	2	Human	Functional	pEC50	=	7.6	7.6	1	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.01.154
	90663958	106835	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	482	12	4	3	3.8	C[C@H](NCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144491	106835	None	0	Human	Functional	pEC50	=	7.6	7.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	482	12	4	3	3.8	C[C@H](NCCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	25129212	74218	None	0	Human	Functional	pEC50	=	7.6	7.6	7	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	574	5	2	6	5.2	CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1016/j.bmc.2012.03.029
	CHEMBL2023112	74218	None	0	Human	Functional	pEC50	=	7.6	7.6	7	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	574	5	2	6	5.2	CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1016/j.bmc.2012.03.029
	46884629	8381	None	0	Mouse	Functional	pEC50	=	7.6	7.6	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093183	8381	None	0	Mouse	Functional	pEC50	=	7.6	7.6	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	54587369	60853	None	0	Mouse	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	354	4	3	5	2.6	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762253	60853	None	0	Mouse	Functional	pEC50	=	6.6	6.6	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	354	4	3	5	2.6	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1	10.1016/j.bmcl.2011.02.011
	54583452	60867	None	0	Human	Functional	pEC50	=	5.6	5.6	-7	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	399	5	2	4	4.8	CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762269	60867	None	0	Human	Functional	pEC50	=	5.6	5.6	-7	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	399	5	2	4	4.8	CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1	10.1016/j.bmcl.2011.02.011
	46882012	5894	None	0	Human	Functional	pEC50	=	5.6	5.6	-5	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	404	11	2	2	6.6	CCCCc1cnc(C(CCCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079518	5894	None	0	Human	Functional	pEC50	=	5.6	5.6	-5	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	404	11	2	2	6.6	CCCCc1cnc(C(CCCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46881507	7467	None	0	Human	Functional	pEC50	=	5.6	5.6	-16	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1086912	7467	None	0	Human	Functional	pEC50	=	5.6	5.6	-16	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46889232	7515	None	0	Mouse	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	401	6	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087200	7515	None	0	Mouse	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	401	6	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	25129212	74218	None	0	Mouse	Functional	pEC50	=	7.6	7.6	-7	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	574	5	2	6	5.2	CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1016/j.bmc.2012.03.029
	CHEMBL2023112	74218	None	0	Mouse	Functional	pEC50	=	7.6	7.6	-7	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	574	5	2	6	5.2	CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1016/j.bmc.2012.03.029
	54583453	60869	None	0	Mouse	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	389	5	3	5	3.5	CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762271	60869	None	0	Mouse	Functional	pEC50	=	6.6	6.6	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	389	5	3	5	3.5	CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1	10.1016/j.bmcl.2011.02.011
	44300482	200037	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	487	9	4	3	4.4	O=C(N/N=C/c1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL57046	200037	None	0	Human	Functional	pEC50	=	5.6	5.6	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	487	9	4	3	4.4	O=C(N/N=C/c1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46881961	5833	None	0	Human	Functional	pEC50	=	5.6	5.6	-28	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	348	8	2	2	4.9	CCCCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079114	5833	None	0	Human	Functional	pEC50	=	5.6	5.6	-28	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	348	8	2	2	4.9	CCCCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46881920	8326	None	0	Human	Functional	pEC50	=	5.6	5.6	-7	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	9	2	2	5.9	CCCCc1cnc(C(CC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1092798	8326	None	0	Human	Functional	pEC50	=	5.6	5.6	-7	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	9	2	2	5.9	CCCCc1cnc(C(CC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46881644	7845	None	0	Mouse	Functional	pEC50	=	5.6	5.6	1	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	348	5	2	2	4.9	CC(C)(C)c1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1089720	7845	None	0	Mouse	Functional	pEC50	=	5.6	5.6	1	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	348	5	2	2	4.9	CC(C)(C)c1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46881921	8059	None	0	Human	Functional	pEC50	=	5.6	5.6	-15	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	8	2	2	5.5	CCCCc1cnc(C(C)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1091087	8059	None	0	Human	Functional	pEC50	=	5.6	5.6	-15	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	8	2	2	5.5	CCCCc1cnc(C(C)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	59618710	82812	None	0	Human	Functional	pEC50	=	6.6	6.6	7	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	473	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2	10.1021/ml200207w
	CHEMBL2179910	82812	None	0	Human	Functional	pEC50	=	6.6	6.6	7	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	473	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2	10.1021/ml200207w
	172452178	195831	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	451	7	2	9	4.1	C=CC(C)(C)C(OC(=O)c1ccncc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5411592	195831	None	0	Human	Functional	pEC50	=	6.6	6.6	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	451	7	2	9	4.1	C=CC(C)(C)C(OC(=O)c1ccncc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46884688	8175	None	0	Mouse	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091918	8175	None	0	Mouse	Functional	pEC50	=	7.6	7.6	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	53242205	60847	None	0	Mouse	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762247	60847	None	0	Mouse	Functional	pEC50	=	7.6	7.6	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46889210	7534	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	387	6	2	2	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087443	7534	None	0	Human	Functional	pEC50	=	7.5	7.5	-1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	387	6	2	2	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	46882010	6064	None	0	Human	Functional	pEC50	=	6.5	6.5	-13	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3Cl)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1080581	6064	None	0	Human	Functional	pEC50	=	6.5	6.5	-13	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3Cl)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46884630	8422	None	0	Mouse	Functional	pEC50	=	8.5	8.5	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093459	8422	None	0	Mouse	Functional	pEC50	=	8.5	8.5	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	44300356	200703	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	483	9	5	3	3.0	O=C(Cc1ccccc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL57559	200703	None	0	Human	Functional	pEC50	=	8.5	8.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	483	9	5	3	3.0	O=C(Cc1ccccc1)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	132427043	195579	None	3	Human	Functional	pEC50	=	8.4	8.4	-2	3	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Human	Functional	pEC50	=	8.4	8.4	-2	3	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46884628	8255	None	0	Mouse	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092381	8255	None	0	Mouse	Functional	pEC50	=	8.4	8.4	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL525577	218143	None	0	Human	Functional	pEC50	=	8.4	8.4	-64	3	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O	10.1016/j.bmcl.2008.09.033
	25025863	8501	None	0	Human	Functional	pEC50	=	7.5	7.5	-4	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	430	10	2	5	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1094054	8501	None	0	Human	Functional	pEC50	=	7.5	7.5	-4	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	430	10	2	5	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46881683	8364	None	0	Mouse	Functional	pEC50	=	7.5	7.5	2	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	9	2	2	5.9	CCC(C)(CC)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1093080	8364	None	0	Mouse	Functional	pEC50	=	7.5	7.5	2	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	9	2	2	5.9	CCC(C)(CC)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	44300275	203998	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	522	11	3	3	4.5	O=C(CN1CCC(Cc2ccccc2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL60537	203998	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	522	11	3	3	4.5	O=C(CN1CCC(Cc2ccccc2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46884578	8182	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091984	8182	None	0	Human	Functional	pEC50	=	6.5	6.5	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46885313	8104	None	0	Mouse	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091554	8104	None	0	Mouse	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46881508	7468	None	0	Mouse	Functional	pEC50	=	7.5	7.5	26	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(Cl)c3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1086913	7468	None	0	Mouse	Functional	pEC50	=	7.5	7.5	26	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(Cl)c3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	90663963	106840	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	551	11	5	4	3.3	C[C@H](NC(=O)CC1NCCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144496	106840	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	551	11	5	4	3.3	C[C@H](NC(=O)CC1NCCc2ccccc21)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	172465965	196684	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	478	8	2	9	4.6	C=CC(C)(C)C(OC(=O)c1ccc(C=O)cc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5429857	196684	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	478	8	2	9	4.6	C=CC(C)(C)C(OC(=O)c1ccc(C=O)cc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46887980	9091	None	0	Human	Functional	pEC50	=	5.5	5.5	-24	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	404	4	2	5	3.5	CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1099122	9091	None	0	Human	Functional	pEC50	=	5.5	5.5	-24	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	404	4	2	5	3.5	CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	90663967	106844	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	497	11	4	4	2.7	C[C@H](NC(=O)Cc1cccnc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144500	106844	None	0	Human	Functional	pEC50	=	7.5	7.5	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	497	11	4	4	2.7	C[C@H](NC(=O)Cc1cccnc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	54585379	60859	None	0	Mouse	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762261	60859	None	0	Mouse	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54586337	60860	None	0	Mouse	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762262	60860	None	0	Mouse	Functional	pEC50	=	6.5	6.5	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	59618646	82699	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	421	2	1	4	5.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2	10.1021/ml200207w
	CHEMBL2179482	82699	None	0	Human	Functional	pEC50	=	6.5	6.5	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	421	2	1	4	5.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2	10.1021/ml200207w
	54580463	60855	None	0	Mouse	Functional	pEC50	=	7.5	7.5	11	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762255	60855	None	0	Mouse	Functional	pEC50	=	7.5	7.5	11	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	56840673	1141	None	0	Mouse	Functional	pEC50	=	7.5	7.5	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	8503	1141	None	0	Mouse	Functional	pEC50	=	7.5	7.5	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	CHEMBL2164575	1141	None	0	Mouse	Functional	pEC50	=	7.5	7.5	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	46881603	9134	None	0	Mouse	Functional	pEC50	=	7.5	7.5	19	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	402	8	2	2	6.1	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCC3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1099370	9134	None	0	Mouse	Functional	pEC50	=	7.5	7.5	19	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	402	8	2	2	6.1	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCC3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	136086809	7445	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	445	10	3	4	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=O)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086684	7445	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	445	10	3	4	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=O)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46881605	8873	None	0	Human	Functional	pEC50	=	6.5	6.5	-14	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	7	2	3	4.5	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1097363	8873	None	0	Human	Functional	pEC50	=	6.5	6.5	-14	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	7	2	3	4.5	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	123695309	196718	None	0	Human	Functional	pEC50	=	5.5	5.5	-4	2	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5430646	196718	None	0	Human	Functional	pEC50	=	5.5	5.5	-4	2	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46889146	7685	None	0	Mouse	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	348	7	2	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088684	7685	None	0	Mouse	Functional	pEC50	=	7.5	7.5	1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	348	7	2	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1	10.1016/j.bmcl.2010.03.028
	54581472	60861	None	0	Mouse	Functional	pEC50	=	6.5	6.5	18	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	365	4	3	4	3.1	CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762263	60861	None	0	Mouse	Functional	pEC50	=	6.5	6.5	18	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	365	4	3	4	3.1	CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46881920	8326	None	0	Mouse	Functional	pEC50	=	6.5	6.5	7	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	9	2	2	5.9	CCCCc1cnc(C(CC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1092798	8326	None	0	Mouse	Functional	pEC50	=	6.5	6.5	7	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	9	2	2	5.9	CCCCc1cnc(C(CC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46887912	9027	None	0	Rat	Functional	pEC50	=	6.5	6.5	16	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	396	3	2	5	3.7	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1Cl)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098513	9027	None	0	Rat	Functional	pEC50	=	6.5	6.5	16	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	396	3	2	5	3.7	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1Cl)C3	10.1016/j.bmcl.2010.03.065
	46887877	8974	None	0	Rat	Functional	pEC50	=	6.5	6.5	19	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	363	3	2	6	2.5	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccn1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098188	8974	None	0	Rat	Functional	pEC50	=	6.5	6.5	19	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	363	3	2	6	2.5	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccn1)C3	10.1016/j.bmcl.2010.03.065
	46887981	9092	None	0	Human	Functional	pEC50	=	5.5	5.5	-28	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	418	5	2	5	3.9	CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1099123	9092	None	0	Human	Functional	pEC50	=	5.5	5.5	-28	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	418	5	2	5	3.9	CCC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	54580462	60851	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	422	6	3	5	3.9	CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762251	60851	None	0	Human	Functional	pEC50	=	6.5	6.5	-4	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	422	6	3	5	3.9	CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	44589874	188512	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	344	4	1	4	4.3	COc1ccc2nc(C(C)Cc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	CHEMBL501895	188512	None	0	Human	Functional	pEC50	=	6.5	6.5	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	344	4	1	4	4.3	COc1ccc2nc(C(C)Cc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	3288900	8956	None	5	Rat	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	364	3	2	6	1.9	Nc1n[nH]c2nc(N3CCOCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098098	8956	None	5	Rat	Functional	pEC50	=	5.5	5.5	2	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	364	3	2	6	1.9	Nc1n[nH]c2nc(N3CCOCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46884628	8255	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092381	8255	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618710	82812	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-7	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	473	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2	10.1021/ml200207w
	CHEMBL2179910	82812	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-7	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	473	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2	10.1021/ml200207w
	46881604	8872	None	0	Human	Functional	pEC50	=	6.4	6.4	-25	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	6	2	2	5.6	O=C(O)c1ccccc1-c1ccc(CCc2ncc(C3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1097362	8872	None	0	Human	Functional	pEC50	=	6.4	6.4	-25	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	6	2	2	5.6	O=C(O)c1ccccc1-c1ccc(CCc2ncc(C3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	71460964	82815	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-11	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	2	1	4	6.2	Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179913	82815	None	0	Mouse	Functional	pEC50	=	6.4	6.4	-11	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	2	1	4	6.2	Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	59618709	82809	None	0	Human	Functional	pEC50	=	7.4	7.4	14	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	455	2	1	4	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2	10.1021/ml200207w
	CHEMBL2179908	82809	None	0	Human	Functional	pEC50	=	7.4	7.4	14	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	455	2	1	4	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2	10.1021/ml200207w
	54582478	60872	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762274	60872	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	4254919	8658	None	6	Rat	Functional	pEC50	=	6.4	6.4	12	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	362	3	2	5	3.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095423	8658	None	6	Rat	Functional	pEC50	=	6.4	6.4	12	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	362	3	2	5	3.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	4581089	194010	None	2	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	348	4	1	5	4.2	COc1ccc2nc(SCc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	CHEMBL527650	194010	None	2	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	348	4	1	5	4.2	COc1ccc2nc(SCc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	46882059	5954	None	0	Mouse	Functional	pEC50	=	6.4	6.4	14	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	9	2	2	5.3	CCCCc1cnc(CCCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079869	5954	None	0	Mouse	Functional	pEC50	=	6.4	6.4	14	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	9	2	2	5.3	CCCCc1cnc(CCCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46887914	14235	None	0	Rat	Functional	pEC50	=	5.4	5.4	2	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	380	3	2	5	3.2	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc(F)cc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1199153	14235	None	0	Rat	Functional	pEC50	=	5.4	5.4	2	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	380	3	2	5	3.2	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc(F)cc1)C3	10.1016/j.bmcl.2010.03.065
	54581471	60852	None	0	Mouse	Functional	pEC50	=	7.4	7.4	6	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	444	5	3	5	3.6	O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762252	60852	None	0	Mouse	Functional	pEC50	=	7.4	7.4	6	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	444	5	3	5	3.6	O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46881643	7783	None	0	Human	Functional	pEC50	=	7.4	7.4	-6	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	7	2	2	5.5	CC(C)(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1089382	7783	None	0	Human	Functional	pEC50	=	7.4	7.4	-6	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	7	2	2	5.5	CC(C)(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	155794	209091	None	60	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	329	5	1	5	3.9	COc1ccc2nc(SCc3ncc(C)c(OC)c3C)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	CHEMBL892	209091	None	60	Human	Functional	pEC50	=	5.4	5.4	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	329	5	1	5	3.9	COc1ccc2nc(SCc3ncc(C)c(OC)c3C)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	46889209	7533	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	429	10	2	4	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3cnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087442	7533	None	0	Human	Functional	pEC50	=	6.4	6.4	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	429	10	2	4	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3cnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	90663959	106836	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	502	11	4	3	4.4	C[C@H](NCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144492	106836	None	0	Human	Functional	pEC50	=	8.4	8.4	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	502	11	4	3	4.4	C[C@H](NCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46884577	8114	None	0	Mouse	Functional	pEC50	=	8.4	8.4	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091599	8114	None	0	Mouse	Functional	pEC50	=	8.4	8.4	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889176	7444	None	0	Mouse	Functional	pEC50	=	8.3	8.3	10	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	444	10	3	5	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086674	7444	None	0	Mouse	Functional	pEC50	=	8.3	8.3	10	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	444	10	3	5	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46885311	8317	None	0	Mouse	Functional	pEC50	=	8.3	8.3	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092730	8317	None	0	Mouse	Functional	pEC50	=	8.3	8.3	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	132427046	195173	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	450	7	2	8	4.7	C=CC(C)(C)C(OC(=O)c1ccccc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5398098	195173	None	0	Human	Functional	pEC50	=	8.3	8.3	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	450	7	2	8	4.7	C=CC(C)(C)C(OC(=O)c1ccccc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	62707364	81906	None	0	Human	Functional	pEC50	=	7.4	7.4	8	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	529	3	1	7	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1	10.1021/ml200304j
	CHEMBL2164580	81906	None	0	Human	Functional	pEC50	=	7.4	7.4	8	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	529	3	1	7	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1	10.1021/ml200304j
	54583453	60869	None	0	Human	Functional	pEC50	=	5.4	5.4	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	389	5	3	5	3.5	CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762271	60869	None	0	Human	Functional	pEC50	=	5.4	5.4	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	389	5	3	5	3.5	CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1	10.1016/j.bmcl.2011.02.011
	54581474	60870	None	0	Human	Functional	pEC50	=	5.4	5.4	-4	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	376	6	3	6	2.7	CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762272	60870	None	0	Human	Functional	pEC50	=	5.4	5.4	-4	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	376	6	3	6	2.7	CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	46887946	8793	None	0	Rat	Functional	pEC50	=	6.4	6.4	25	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	406	3	2	7	2.8	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc2c(c1)OCO2)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1096546	8793	None	0	Rat	Functional	pEC50	=	6.4	6.4	25	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	406	3	2	7	2.8	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccc2c(c1)OCO2)C3	10.1016/j.bmcl.2010.03.065
	46861857	7442	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	461	10	3	4	6.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086672	7442	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	461	10	3	4	6.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46881601	9076	None	0	Human	Functional	pEC50	=	7.4	7.4	-5	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	388	7	2	2	5.7	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1099032	9076	None	0	Human	Functional	pEC50	=	7.4	7.4	-5	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	388	7	2	2	5.7	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	54581474	60870	None	0	Mouse	Functional	pEC50	=	6.4	6.4	4	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	376	6	3	6	2.7	CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762272	60870	None	0	Mouse	Functional	pEC50	=	6.4	6.4	4	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	376	6	3	6	2.7	CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	46881962	6175	None	0	Human	Functional	pEC50	=	5.4	5.4	-52	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	CHEMBL1081130	6175	None	0	Human	Functional	pEC50	=	5.4	5.4	-52	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	46888019	9065	None	0	Rat	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	458	5	2	5	4.6	O=C(Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3)C1CCCC1	10.1016/j.bmcl.2010.03.065
	CHEMBL1098838	9065	None	0	Rat	Functional	pEC50	=	6.4	6.4	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	458	5	2	5	4.6	O=C(Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3)C1CCCC1	10.1016/j.bmcl.2010.03.065
	46888067	8675	None	0	Human	Functional	pEC50	=	5.4	5.4	-6	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	432	5	2	5	5.0	CC(C)(C)CNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095529	8675	None	0	Human	Functional	pEC50	=	5.4	5.4	-6	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	432	5	2	5	5.0	CC(C)(C)CNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	59618747	81902	None	0	Human	Functional	pEC50	=	7.4	7.4	6	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	538	3	1	5	6.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1	10.1021/ml200304j
	CHEMBL2164576	81902	None	0	Human	Functional	pEC50	=	7.4	7.4	6	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	538	3	1	5	6.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1	10.1021/ml200304j
	46889235	7661	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	406	8	2	4	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088411	7661	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	406	8	2	4	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	25026058	7671	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	377	7	2	3	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088553	7671	None	0	Human	Functional	pEC50	=	7.4	7.4	-2	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	377	7	2	3	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1	10.1016/j.bmcl.2010.03.028
	46884687	8174	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091917	8174	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884576	8113	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091598	8113	None	0	Human	Functional	pEC50	=	6.4	6.4	-4	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	59618698	82693	None	0	Human	Functional	pEC50	=	7.4	7.4	6	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	517	3	1	5	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179476	82693	None	0	Human	Functional	pEC50	=	7.4	7.4	6	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	517	3	1	5	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	54580465	60857	None	0	Mouse	Functional	pEC50	=	5.4	5.4	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	390	5	3	5	3.2	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762258	60857	None	0	Mouse	Functional	pEC50	=	5.4	5.4	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	390	5	3	5	3.2	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1	10.1016/j.bmcl.2011.02.011
	46881472	7664	None	0	Human	Functional	pEC50	=	5.4	5.4	-56	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	CHEMBL1088468	7664	None	0	Human	Functional	pEC50	=	5.4	5.4	-56	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	46884661	7820	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089512	7820	None	0	Human	Functional	pEC50	=	6.4	6.4	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46888018	9064	None	0	Rat	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	460	5	2	5	4.9	CC(C)(C)CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098837	9064	None	0	Rat	Functional	pEC50	=	6.4	6.4	2	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	460	5	2	5	4.9	CC(C)(C)CC(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46881644	7845	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	348	5	2	2	4.9	CC(C)(C)c1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1089720	7845	None	0	Human	Functional	pEC50	=	5.4	5.4	-1	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	348	5	2	2	4.9	CC(C)(C)c1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46882060	6315	None	0	Human	Functional	pEC50	=	5.4	5.4	2	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	346	7	2	2	5.3	CCCCc1cnc(/C=C/c2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1081866	6315	None	0	Human	Functional	pEC50	=	5.4	5.4	2	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	346	7	2	2	5.3	CCCCc1cnc(/C=C/c2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46884660	6444	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1082471	6444	None	0	Human	Functional	pEC50	=	7.4	7.4	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	1214469	60845	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762245	60845	None	0	Human	Functional	pEC50	=	6.4	6.4	-5	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54587369	60853	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	354	4	3	5	2.6	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762253	60853	None	0	Human	Functional	pEC50	=	6.4	6.4	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	354	4	3	5	2.6	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1	10.1016/j.bmcl.2011.02.011
	54580463	60855	None	0	Human	Functional	pEC50	=	6.4	6.4	-11	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762255	60855	None	0	Human	Functional	pEC50	=	6.4	6.4	-11	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL403317	214990	None	22	Human	Functional	pEC50	=	5.4	5.4	-6309	4	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CN)[C@@H](C)O)C(N)=O	10.1021/jm0210921
	4254919	8658	None	6	Human	Functional	pEC50	=	5.3	5.3	-12	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	362	3	2	5	3.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095423	8658	None	6	Human	Functional	pEC50	=	5.3	5.3	-12	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	362	3	2	5	3.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	90663962	106839	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	468	11	4	3	3.7	C[C@H](NCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144495	106839	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	468	11	4	3	3.7	C[C@H](NCc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46882057	5924	None	0	Human	Functional	pEC50	=	5.3	5.3	-2	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	9	2	2	6.1	CCCCc1cnc(C(Cc2ccc(-c3ccccc3C(=O)O)cc2)C(C)C)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079696	5924	None	0	Human	Functional	pEC50	=	5.3	5.3	-2	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	9	2	2	6.1	CCCCc1cnc(C(Cc2ccc(-c3ccccc3C(=O)O)cc2)C(C)C)[nH]1	10.1016/j.bmcl.2010.01.154
	25025860	569	None	23	Human	Functional	pEC50	=	7.3	7.3	-14	5	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	6188	569	None	23	Human	Functional	pEC50	=	7.3	7.3	-14	5	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1091720	569	None	23	Human	Functional	pEC50	=	7.3	7.3	-14	5	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	25025860	569	None	23	Human	Functional	pEC50	=	7.3	7.3	-14	5	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1021/ml100196d
	6188	569	None	23	Human	Functional	pEC50	=	7.3	7.3	-14	5	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1021/ml100196d
	CHEMBL1091720	569	None	23	Human	Functional	pEC50	=	7.3	7.3	-14	5	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1021/ml100196d
	46888066	8674	None	0	Rat	Functional	pEC50	=	6.3	6.3	21	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	390	5	2	5	3.9	CCNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095528	8674	None	0	Rat	Functional	pEC50	=	6.3	6.3	21	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	390	5	2	5	3.9	CCNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887982	8746	None	0	Human	Functional	pEC50	=	5.3	5.3	-47	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	432	5	2	5	4.1	CC(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1096193	8746	None	0	Human	Functional	pEC50	=	5.3	5.3	-47	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	432	5	2	5	4.1	CC(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46887824	8955	None	0	Rat	Functional	pEC50	=	6.3	6.3	20	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	380	3	2	5	3.0	Nc1n[nH]c2nc(N3CCC(F)CC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098097	8955	None	0	Rat	Functional	pEC50	=	6.3	6.3	20	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	380	3	2	5	3.0	Nc1n[nH]c2nc(N3CCC(F)CC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	25128865	82690	None	0	Human	Functional	pEC50	=	7.3	7.3	9	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	3	1	4	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179473	82690	None	0	Human	Functional	pEC50	=	7.3	7.3	9	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	3	1	4	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	54581470	60848	None	0	Mouse	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762248	60848	None	0	Mouse	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54584420	60862	None	0	Mouse	Functional	pEC50	=	5.3	5.3	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	365	5	2	5	2.9	CC(C)(C)CC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762264	60862	None	0	Mouse	Functional	pEC50	=	5.3	5.3	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	365	5	2	5	2.9	CC(C)(C)CC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46882061	6352	None	0	Human	Functional	pEC50	=	5.3	5.3	-5	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	368	6	2	2	5.2	O=C(O)c1ccccc1-c1ccc(CCc2ncc(-c3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1082041	6352	None	0	Human	Functional	pEC50	=	5.3	5.3	-5	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	368	6	2	2	5.2	O=C(O)c1ccccc1-c1ccc(CCc2ncc(-c3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46881602	9077	None	0	Mouse	Functional	pEC50	=	8.2	8.2	15	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	402	7	2	2	6.1	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1099033	9077	None	0	Mouse	Functional	pEC50	=	8.2	8.2	15	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	402	7	2	2	6.1	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46861857	7442	None	0	Mouse	Functional	pEC50	=	8.2	8.2	2	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	461	10	3	4	6.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086672	7442	None	0	Mouse	Functional	pEC50	=	8.2	8.2	2	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	461	10	3	4	6.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	59618678	82808	None	0	Human	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	446	2	1	5	5.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2	10.1021/ml200207w
	CHEMBL2179907	82808	None	0	Human	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	446	2	1	5	5.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2	10.1021/ml200207w
	66901749	82813	None	0	Human	Functional	pEC50	=	7.3	7.3	18	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	2	1	4	6.2	Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179911	82813	None	0	Human	Functional	pEC50	=	7.3	7.3	18	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	2	1	4	6.2	Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	59618678	82808	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-3	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	446	2	1	5	5.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2	10.1021/ml200207w
	CHEMBL2179907	82808	None	0	Mouse	Functional	pEC50	=	7.3	7.3	-3	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	446	2	1	5	5.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2	10.1021/ml200207w
	46881558	7335	None	0	Mouse	Functional	pEC50	=	7.3	7.3	31	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(F)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1086177	7335	None	0	Mouse	Functional	pEC50	=	7.3	7.3	31	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccc(F)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	54580461	60850	None	0	Human	Functional	pEC50	=	7.3	7.3	-4	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	380	6	3	5	2.9	CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762250	60850	None	0	Human	Functional	pEC50	=	7.3	7.3	-4	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	380	6	3	5	2.9	CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54582478	60872	None	0	Mouse	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762274	60872	None	0	Mouse	Functional	pEC50	=	7.3	7.3	3	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	25110720	178933	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	332	4	1	5	3.5	COc1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	CHEMBL469313	178933	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	332	4	1	5	3.5	COc1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	46881963	6176	None	0	Mouse	Functional	pEC50	=	6.3	6.3	10	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1081131	6176	None	0	Mouse	Functional	pEC50	=	6.3	6.3	10	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	59618790	81819	None	0	Human	Functional	pEC50	=	7.3	7.3	12	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	587	4	2	8	6.1	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	CHEMBL2164223	81819	None	0	Human	Functional	pEC50	=	7.3	7.3	12	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	587	4	2	8	6.1	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	62707365	81908	None	0	Human	Functional	pEC50	=	7.3	7.3	11	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	4	2	8	6.0	C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164582	81908	None	0	Human	Functional	pEC50	=	7.3	7.3	11	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	4	2	8	6.0	C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	132427031	195960	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	430	8	2	8	4.5	C=CC(C)(C)C(OC(=O)CC(C)C)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5414271	195960	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	430	8	2	8	4.5	C=CC(C)(C)C(OC(=O)CC(C)C)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	141325733	196323	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	416	9	2	7	5.1	COc1cc(C(CC=C(C)C)OCCC(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5421389	196323	None	0	Human	Functional	pEC50	=	6.3	6.3	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	416	9	2	7	5.1	COc1cc(C(CC=C(C)C)OCCC(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46885313	8104	None	0	Human	Functional	pEC50	=	5.3	5.3	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091554	8104	None	0	Human	Functional	pEC50	=	5.3	5.3	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46882012	5894	None	0	Mouse	Functional	pEC50	=	6.3	6.3	5	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	404	11	2	2	6.6	CCCCc1cnc(C(CCCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079518	5894	None	0	Mouse	Functional	pEC50	=	6.3	6.3	5	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	404	11	2	2	6.6	CCCCc1cnc(C(CCCC)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46881963	6176	None	0	Human	Functional	pEC50	=	5.3	5.3	-10	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1081131	6176	None	0	Human	Functional	pEC50	=	5.3	5.3	-10	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46884659	7819	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089511	7819	None	0	Human	Functional	pEC50	=	6.3	6.3	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889148	7687	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	406	10	2	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCC(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088686	7687	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	406	10	2	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCC(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	132427043	195579	None	3	Mouse	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Mouse	Functional	pEC50	=	7.3	7.3	-1	3	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	59618778	82692	None	0	Human	Functional	pEC50	=	6.3	6.3	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	511	3	1	6	4.6	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179475	82692	None	0	Human	Functional	pEC50	=	6.3	6.3	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	511	3	1	6	4.6	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46888020	9098	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	460	6	2	5	4.9	CCC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1099135	9098	None	0	Human	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	460	6	2	5	4.9	CCC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46881419	6860	None	0	Human	Functional	pEC50	=	5.3	5.3	-8	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084130	6860	None	0	Human	Functional	pEC50	=	5.3	5.3	-8	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	53242205	60847	None	0	Human	Functional	pEC50	=	7.3	7.3	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762247	60847	None	0	Human	Functional	pEC50	=	7.3	7.3	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46887912	9027	None	0	Human	Functional	pEC50	=	5.3	5.3	-16	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	396	3	2	5	3.7	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1Cl)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098513	9027	None	0	Human	Functional	pEC50	=	5.3	5.3	-16	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	396	3	2	5	3.7	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1Cl)C3	10.1016/j.bmcl.2010.03.065
	46882059	5954	None	0	Human	Functional	pEC50	=	5.3	5.3	-14	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	9	2	2	5.3	CCCCc1cnc(CCCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079869	5954	None	0	Human	Functional	pEC50	=	5.3	5.3	-14	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	9	2	2	5.3	CCCCc1cnc(CCCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	59618753	81907	None	0	Human	Functional	pEC50	=	7.3	7.3	14	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	559	4	2	8	5.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1	10.1021/ml200304j
	CHEMBL2164581	81907	None	0	Human	Functional	pEC50	=	7.3	7.3	14	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	559	4	2	8	5.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1	10.1021/ml200304j
	46889232	7515	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	401	6	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087200	7515	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	401	6	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	46889145	9078	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	398	7	2	4	4.8	c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1	10.1016/j.bmcl.2010.03.028
	CHEMBL1099034	9078	None	0	Human	Functional	pEC50	=	7.3	7.3	-1	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	398	7	2	4	4.8	c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1	10.1016/j.bmcl.2010.03.028
	59618778	82692	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	511	3	1	6	4.6	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179475	82692	None	0	Mouse	Functional	pEC50	=	6.3	6.3	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	511	3	1	6	4.6	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46884663	7825	None	0	Mouse	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089523	7825	None	0	Mouse	Functional	pEC50	=	7.2	7.2	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	62707364	81906	None	0	Mouse	Functional	pEC50	=	7.2	7.2	-8	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	529	3	1	7	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1	10.1021/ml200304j
	CHEMBL2164580	81906	None	0	Mouse	Functional	pEC50	=	7.2	7.2	-8	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	529	3	1	7	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1	10.1021/ml200304j
	90663966	106843	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	592	14	6	4	3.0	NC(=O)CC[C@H](NC(=O)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144499	106843	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	592	14	6	4	3.0	NC(=O)CC[C@H](NC(=O)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46884662	7824	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089522	7824	None	0	Human	Functional	pEC50	=	6.2	6.2	-6	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	44589928	179110	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	336	3	1	4	4.2	Clc1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	CHEMBL471016	179110	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Agonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayAgonist activity at recombinant BRS-3 receptor expressed in baculovirus-transduced HEK293 cells assessed as intracellular calcium mobilization by FLIPR assay	ChEMBL	336	3	1	4	4.2	Clc1ccc2nc(COc3cc4c(cc3Cl)OCO4)[nH]c2c1	10.1016/j.bmcl.2008.09.033
	59618747	81902	None	0	Mouse	Functional	pEC50	=	7.2	7.2	-6	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	538	3	1	5	6.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1	10.1021/ml200304j
	CHEMBL2164576	81902	None	0	Mouse	Functional	pEC50	=	7.2	7.2	-6	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	538	3	1	5	6.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1	10.1021/ml200304j
	46881561	6995	None	0	Human	Functional	pEC50	=	6.2	6.2	-83	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	360	7	2	2	4.9	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084698	6995	None	0	Human	Functional	pEC50	=	6.2	6.2	-83	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	360	7	2	2	4.9	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46881964	6177	None	0	Human	Functional	pEC50	=	5.2	5.2	-8	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1081132	6177	None	0	Human	Functional	pEC50	=	5.2	5.2	-8	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	172457037	196351	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	469	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1cncc(F)c1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5422040	196351	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	469	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1cncc(F)c1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	54584421	60863	None	0	Mouse	Functional	pEC50	=	6.2	6.2	13	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	367	4	2	6	2.9	CC(C)(C)OC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762265	60863	None	0	Mouse	Functional	pEC50	=	6.2	6.2	13	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	367	4	2	6	2.9	CC(C)(C)OC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	44300407	199378	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	489	10	5	3	4.1	O=C(NNCc1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL56626	199378	None	0	Human	Functional	pEC50	=	8.2	8.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	489	10	5	3	4.1	O=C(NNCc1ccc(Cl)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	132427043	195579	None	3	Rat	Functional	pEC50	=	8.2	8.2	1	3	Agonist activity at rat BB3 transiently expressed in human HEK293T cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at rat BB3 transiently expressed in human HEK293T cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Rat	Functional	pEC50	=	8.2	8.2	1	3	Agonist activity at rat BB3 transiently expressed in human HEK293T cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at rat BB3 transiently expressed in human HEK293T cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46881643	7783	None	0	Mouse	Functional	pEC50	=	8.2	8.2	6	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	7	2	2	5.5	CC(C)(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1089382	7783	None	0	Mouse	Functional	pEC50	=	8.2	8.2	6	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	7	2	2	5.5	CC(C)(C)CCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	25025858	7784	None	0	Mouse	Functional	pEC50	=	8.2	8.2	16	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	6	2	2	5.1	CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1089383	7784	None	0	Mouse	Functional	pEC50	=	8.2	8.2	16	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	362	6	2	2	5.1	CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46884660	6444	None	0	Mouse	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1082471	6444	None	0	Mouse	Functional	pEC50	=	8.2	8.2	1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618730	82695	None	0	Human	Functional	pEC50	=	7.2	7.2	4	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	500	3	1	5	6.0	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179478	82695	None	0	Human	Functional	pEC50	=	7.2	7.2	4	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	500	3	1	5	6.0	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46888068	8677	None	0	Rat	Functional	pEC50	=	5.2	5.2	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	1	6	3.1	Cn1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095530	8677	None	0	Rat	Functional	pEC50	=	5.2	5.2	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	1	6	3.1	Cn1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3	10.1016/j.bmcl.2010.03.065
	123695309	196718	None	0	Mouse	Functional	pEC50	=	6.2	6.2	4	2	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5430646	196718	None	0	Mouse	Functional	pEC50	=	6.2	6.2	4	2	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46885311	8317	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092730	8317	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	46884630	8422	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093459	8422	None	0	Human	Functional	pEC50	=	7.2	7.2	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	62707362	81903	None	0	Human	Functional	pEC50	=	7.2	7.2	14	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	541	3	1	6	6.3	Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1	10.1021/ml200304j
	CHEMBL2164577	81903	None	0	Human	Functional	pEC50	=	7.2	7.2	14	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	541	3	1	6	6.3	Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1	10.1021/ml200304j
	66901760	82814	None	0	Human	Functional	pEC50	=	7.2	7.2	10	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	495	2	1	4	6.5	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1	10.1021/ml200207w
	CHEMBL2179912	82814	None	0	Human	Functional	pEC50	=	7.2	7.2	10	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	495	2	1	4	6.5	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1	10.1021/ml200207w
	46888017	9063	None	0	Rat	Functional	pEC50	=	7.2	7.2	24	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	446	4	2	5	4.5	CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098836	9063	None	0	Rat	Functional	pEC50	=	7.2	7.2	24	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	446	4	2	5	4.5	CC(C)(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	59618821	74216	None	0	Human	Functional	pEC50	=	7.2	7.2	7	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	657	6	2	9	6.4	CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1016/j.bmc.2012.03.029
	CHEMBL2023110	74216	None	0	Human	Functional	pEC50	=	7.2	7.2	7	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	657	6	2	9	6.4	CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1016/j.bmc.2012.03.029
	54585380	60864	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	380	4	2	5	2.8	CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762266	60864	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	380	4	2	5	2.8	CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C	10.1016/j.bmcl.2011.02.011
	54581472	60861	None	0	Human	Functional	pEC50	=	5.2	5.2	-18	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	365	4	3	4	3.1	CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762263	60861	None	0	Human	Functional	pEC50	=	5.2	5.2	-18	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	365	4	3	4	3.1	CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	90663961	106838	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	544	12	4	3	4.3	C[C@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144494	106838	None	0	Human	Functional	pEC50	=	5.2	5.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	544	12	4	3	4.3	C[C@H](NC(=O)CCc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL438926	216272	None	15	Human	Functional	pEC50	=	5.2	5.2	-190	3	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(C)C)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm0210921
	46884663	7825	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089523	7825	None	0	Human	Functional	pEC50	=	6.2	6.2	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46881603	9134	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	402	8	2	2	6.1	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCC3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1099370	9134	None	0	Human	Functional	pEC50	=	6.2	6.2	-19	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	402	8	2	2	6.1	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CCC3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46881419	6860	None	0	Mouse	Functional	pEC50	=	6.2	6.2	8	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084130	6860	None	0	Mouse	Functional	pEC50	=	6.2	6.2	8	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	54583451	60866	None	0	Mouse	Functional	pEC50	=	5.2	5.2	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	380	4	2	5	2.8	CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762268	60866	None	0	Mouse	Functional	pEC50	=	5.2	5.2	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	380	4	2	5	2.8	CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	25025861	8382	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093184	8382	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25025861	8382	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	CHEMBL1093184	8382	None	0	Human	Functional	pEC50	=	7.2	7.2	1	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	132427043	195579	None	3	Mouse	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Mouse	Functional	pEC50	=	7.2	7.2	-1	3	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	25026445	57962	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	367	5	2	3	4.7	CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	CHEMBL1672352	57962	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as induction of intracellular calcium mobilization by aequorin bioluminescence assay	ChEMBL	367	5	2	3	4.7	CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	59618821	74216	None	0	Mouse	Functional	pEC50	=	7.2	7.2	-7	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	657	6	2	9	6.4	CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1016/j.bmc.2012.03.029
	CHEMBL2023110	74216	None	0	Mouse	Functional	pEC50	=	7.2	7.2	-7	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	657	6	2	9	6.4	CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1016/j.bmc.2012.03.029
	46887877	8974	None	0	Human	Functional	pEC50	=	5.2	5.2	-19	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	363	3	2	6	2.5	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccn1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098188	8974	None	0	Human	Functional	pEC50	=	5.2	5.2	-19	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	363	3	2	6	2.5	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccn1)C3	10.1016/j.bmcl.2010.03.065
	46888067	8675	None	0	Rat	Functional	pEC50	=	6.2	6.2	6	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	432	5	2	5	5.0	CC(C)(C)CNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095529	8675	None	0	Rat	Functional	pEC50	=	6.2	6.2	6	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	432	5	2	5	5.0	CC(C)(C)CNc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	54583450	60858	None	0	Human	Functional	pEC50	=	5.2	5.2	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	388	4	3	5	3.0	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21	10.1016/j.bmcl.2011.02.011
	CHEMBL1762259	60858	None	0	Human	Functional	pEC50	=	5.2	5.2	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	388	4	3	5	3.0	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21	10.1016/j.bmcl.2011.02.011
	62707528	81818	None	0	Human	Functional	pEC50	=	7.2	7.2	11	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	4	2	8	6.0	C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164222	81818	None	0	Human	Functional	pEC50	=	7.2	7.2	11	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	4	2	8	6.0	C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	71460937	82694	None	0	Human	Functional	pEC50	=	7.2	7.2	10	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	493	3	1	4	6.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179477	82694	None	0	Human	Functional	pEC50	=	7.2	7.2	10	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	493	3	1	4	6.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	54586336	60856	None	0	Mouse	Functional	pEC50	=	5.2	5.2	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	362	5	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NCc1ccccc1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762257	60856	None	0	Mouse	Functional	pEC50	=	5.2	5.2	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	362	5	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NCc1ccccc1	10.1016/j.bmcl.2011.02.011
	46881561	6995	None	0	Mouse	Functional	pEC50	=	8.2	8.2	83	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	360	7	2	2	4.9	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084698	6995	None	0	Mouse	Functional	pEC50	=	8.2	8.2	83	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	360	7	2	2	4.9	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46881601	9076	None	0	Mouse	Functional	pEC50	=	8.1	8.1	5	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	388	7	2	2	5.7	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1099032	9076	None	0	Mouse	Functional	pEC50	=	8.1	8.1	5	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	388	7	2	2	5.7	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	90663960	106837	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	540	11	4	5	3.0	C[C@H](NC(=O)Cc1ccc2c(c1)OCO2)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144493	106837	None	0	Human	Functional	pEC50	=	8.1	8.1	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	540	11	4	5	3.0	C[C@H](NC(=O)Cc1ccc2c(c1)OCO2)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	25025654	570	None	12	Mouse	Functional	pEC50	=	8.1	8.1	1	3	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	10.1016/j.bmcl.2010.01.154
	6189	570	None	12	Mouse	Functional	pEC50	=	8.1	8.1	1	3	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	10.1016/j.bmcl.2010.01.154
	8506	570	None	12	Mouse	Functional	pEC50	=	8.1	8.1	1	3	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084942	570	None	12	Mouse	Functional	pEC50	=	8.1	8.1	1	3	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	10.1016/j.bmcl.2010.01.154
	46881473	7678	None	0	Mouse	Functional	pEC50	=	8.1	8.1	19	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1088614	7678	None	0	Mouse	Functional	pEC50	=	8.1	8.1	19	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	44300503	100954	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	523	11	3	4	3.4	O=C(CN1CCN(Cc2ccccc2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL293820	100954	None	0	Human	Functional	pEC50	=	7.2	7.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	523	11	3	4	3.4	O=C(CN1CCN(Cc2ccccc2)CC1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	54581473	60865	None	0	Mouse	Functional	pEC50	=	5.2	5.2	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	365	4	4	5	2.3	CC(C)(C)NC(=N)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762267	60865	None	0	Mouse	Functional	pEC50	=	5.2	5.2	1	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	365	4	4	5	2.3	CC(C)(C)NC(=N)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46888019	9065	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	458	5	2	5	4.6	O=C(Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3)C1CCCC1	10.1016/j.bmcl.2010.03.065
	CHEMBL1098838	9065	None	0	Human	Functional	pEC50	=	6.2	6.2	-1	2	Agonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	458	5	2	5	4.6	O=C(Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3)C1CCCC1	10.1016/j.bmcl.2010.03.065
	90663964	106841	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	582	15	6	5	1.9	NC(=O)CC[C@H](NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144497	106841	None	0	Human	Functional	pEC50	=	6.2	6.2	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	582	15	6	5	1.9	NC(=O)CC[C@H](NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46881560	6994	None	0	Mouse	Functional	pEC50	=	7.1	7.1	13	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	346	7	2	2	4.5	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084697	6994	None	0	Mouse	Functional	pEC50	=	7.1	7.1	13	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	346	7	2	2	4.5	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	54584418	60849	None	0	Human	Functional	pEC50	=	6.1	6.1	-6	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762249	60849	None	0	Human	Functional	pEC50	=	6.1	6.1	-6	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	46881964	6177	None	0	Mouse	Functional	pEC50	=	6.1	6.1	8	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1081132	6177	None	0	Mouse	Functional	pEC50	=	6.1	6.1	8	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1ccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46200989	2562	None	14	Human	Functional	pEC50	=	7.1	7.1	9	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	8502	2562	None	14	Human	Functional	pEC50	=	7.1	7.1	9	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	CHEMBL2023109	2562	None	14	Human	Functional	pEC50	=	7.1	7.1	9	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	46881472	7664	None	0	Mouse	Functional	pEC50	=	7.1	7.1	56	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	CHEMBL1088468	7664	None	0	Mouse	Functional	pEC50	=	7.1	7.1	56	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	54586336	60856	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	362	5	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NCc1ccccc1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762257	60856	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	362	5	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NCc1ccccc1	10.1016/j.bmcl.2011.02.011
	46888069	8885	None	0	Rat	Functional	pEC50	=	6.1	6.1	13	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	404	3	1	7	3.2	CC(=O)n1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3	10.1016/j.bmcl.2010.03.065
	CHEMBL1097471	8885	None	0	Rat	Functional	pEC50	=	6.1	6.1	13	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	404	3	1	7	3.2	CC(=O)n1nc(N)c2c3c(c(N4CCCCC4)nc21)CN(Cc1ccccc1)CC3	10.1016/j.bmcl.2010.03.065
	136118727	81905	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	545	3	2	7	5.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1	10.1021/ml200304j
	CHEMBL2164579	81905	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	545	3	2	7	5.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1	10.1021/ml200304j
	25128867	74217	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-10	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	669	6	2	9	6.5	CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1	10.1016/j.bmc.2012.03.029
	CHEMBL2023111	74217	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-10	2	Agonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	669	6	2	9	6.5	CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1	10.1016/j.bmc.2012.03.029
	46881683	8364	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	9	2	2	5.9	CCC(C)(CC)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1093080	8364	None	0	Human	Functional	pEC50	=	7.1	7.1	-2	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	390	9	2	2	5.9	CCC(C)(CC)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46887875	8905	None	0	Rat	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	336	4	3	5	2.9	CC(C)Nc1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2	10.1016/j.bmcl.2010.03.065
	CHEMBL1097551	8905	None	0	Rat	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	336	4	3	5	2.9	CC(C)Nc1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2	10.1016/j.bmcl.2010.03.065
	136118727	81905	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	545	3	2	7	5.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1	10.1021/ml200304j
	CHEMBL2164579	81905	None	0	Human	Functional	pEC50	=	7.1	7.1	1	2	Agonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	545	3	2	7	5.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1	10.1021/ml200304j
	71451990	82817	None	0	Human	Functional	pEC50	=	7.1	7.1	6	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	537	3	2	5	6.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1	10.1021/ml200207w
	CHEMBL2179915	82817	None	0	Human	Functional	pEC50	=	7.1	7.1	6	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	537	3	2	5	6.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1	10.1021/ml200207w
	135398415	195415	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	432	11	3	8	4.1	C=CC(C)(C)C(OCCCCCO)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5403261	195415	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	432	11	3	8	4.1	C=CC(C)(C)C(OCCCCCO)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	123695309	196718	None	0	Mouse	Functional	pEC50	=	6.1	6.1	4	2	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5430646	196718	None	0	Mouse	Functional	pEC50	=	6.1	6.1	4	2	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as increase in intracellular calcium response and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46889176	7444	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	444	10	3	5	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086674	7444	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	2	Agonist activity at human BRS3Agonist activity at human BRS3	ChEMBL	444	10	3	5	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	25025860	569	None	23	Mouse	Functional	pEC50	=	7.1	7.1	-4	5	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	6188	569	None	23	Mouse	Functional	pEC50	=	7.1	7.1	-4	5	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1091720	569	None	23	Mouse	Functional	pEC50	=	7.1	7.1	-4	5	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	59618623	82691	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	501	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179474	82691	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	501	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	59618730	82695	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-4	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	500	3	1	5	6.0	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179478	82695	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-4	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	500	3	1	5	6.0	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46881962	6175	None	0	Mouse	Functional	pEC50	=	7.1	7.1	52	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	CHEMBL1081130	6175	None	0	Mouse	Functional	pEC50	=	7.1	7.1	52	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	412	8	2	3	5.2	COc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	90663957	106834	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	535	11	5	3	3.8	C[C@H](NC(=O)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL3144490	106834	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	535	11	5	3	3.8	C[C@H](NC(=O)Cc1cc2ccccc2[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	44300383	201147	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	535	10	4	4	5.5	O=C(N/N=C/c1ccc(-c2cccs2)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL58097	201147	None	0	Human	Functional	pEC50	=	5.1	5.1	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	535	10	4	4	5.5	O=C(N/N=C/c1ccc(-c2cccs2)cc1)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46887950	9031	None	0	Rat	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	4	2	5	3.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CCc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1098535	9031	None	0	Rat	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	4	2	5	3.1	Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(CCc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46881559	6993	None	0	Mouse	Functional	pEC50	=	8.1	8.1	10	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	418	7	2	2	5.4	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084696	6993	None	0	Mouse	Functional	pEC50	=	8.1	8.1	10	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	418	7	2	2	5.4	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	59618698	82693	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-6	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	517	3	1	5	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179476	82693	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-6	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	517	3	1	5	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	53242205	60847	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762247	60847	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	132427037	196736	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	464	7	2	8	5.0	C=CC(C)(C)C(OC(=O)c1ccc(C)cc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5431181	196736	None	0	Human	Functional	pEC50	=	7.1	7.1	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	464	7	2	8	5.0	C=CC(C)(C)C(OC(=O)c1ccc(C)cc1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	54580465	60857	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	390	5	3	5	3.2	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762258	60857	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	390	5	3	5	3.2	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1	10.1016/j.bmcl.2011.02.011
	46881470	6462	None	0	Human	Functional	pEC50	=	6.1	6.1	-40	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	CHEMBL1082542	6462	None	0	Human	Functional	pEC50	=	6.1	6.1	-40	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	407	7	2	3	5.0	N#Cc1cccc(Cc2cnc(CCc3ccc(-c4ccccc4C(=O)O)cc3)[nH]2)c1	10.1016/j.bmcl.2010.01.154
	25128867	74217	None	0	Human	Functional	pEC50	=	7.1	7.1	10	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	669	6	2	9	6.5	CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1	10.1016/j.bmc.2012.03.029
	CHEMBL2023111	74217	None	0	Human	Functional	pEC50	=	7.1	7.1	10	2	Agonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assayAgonist activity at human BRS3 expressed in human HEK293AEQ cells measured for 10 mins by aequorin bioluminescence assay	ChEMBL	669	6	2	9	6.5	CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1	10.1016/j.bmc.2012.03.029
	54584421	60863	None	0	Human	Functional	pEC50	=	5.1	5.1	-13	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	367	4	2	6	2.9	CC(C)(C)OC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762265	60863	None	0	Human	Functional	pEC50	=	5.1	5.1	-13	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	367	4	2	6	2.9	CC(C)(C)OC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	118539074	196794	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	430	8	2	8	4.6	COc1cc(C(CC=C(C)C)OC(=O)CC(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5432370	196794	None	0	Human	Functional	pEC50	=	6.1	6.1	-	1	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as increase in IP-1 accumulation incubated for 60 mins by HTRF assay	ChEMBL	430	8	2	8	4.6	COc1cc(C(CC=C(C)C)OC(=O)CC(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	46881508	7468	None	0	Human	Functional	pEC50	=	6.1	6.1	-26	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(Cl)c3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1086913	7468	None	0	Human	Functional	pEC50	=	6.1	6.1	-26	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	416	7	2	2	5.8	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(Cl)c3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	59618790	81819	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-12	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	587	4	2	8	6.1	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	CHEMBL2164223	81819	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-12	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	587	4	2	8	6.1	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	54584420	60862	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	365	5	2	5	2.9	CC(C)(C)CC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762264	60862	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	365	5	2	5	2.9	CC(C)(C)CC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54583451	60866	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	380	4	2	5	2.8	CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762268	60866	None	0	Human	Functional	pEC50	=	5.1	5.1	-1	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	380	4	2	5	2.8	CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	25128865	82690	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-9	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	3	1	4	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179473	82690	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-9	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	475	3	1	4	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46887768	8588	None	0	Rat	Functional	pEC50	=	6.1	6.1	11	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	2	5	3.3	CC1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1	10.1016/j.bmcl.2010.03.065
	CHEMBL1094772	8588	None	0	Rat	Functional	pEC50	=	6.1	6.1	11	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	376	3	2	5	3.3	CC1CCN(c2nc3[nH]nc(N)c3c3c2CN(Cc2ccccc2)CC3)CC1	10.1016/j.bmcl.2010.03.065
	1214469	60845	None	0	Mouse	Functional	pEC50	=	7.1	7.1	5	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762245	60845	None	0	Mouse	Functional	pEC50	=	7.1	7.1	5	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46881559	6993	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	418	7	2	2	5.4	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1084696	6993	None	0	Human	Functional	pEC50	=	7.1	7.1	-10	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	418	7	2	2	5.4	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3F)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46882061	6352	None	0	Mouse	Functional	pEC50	=	6.1	6.1	5	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	368	6	2	2	5.2	O=C(O)c1ccccc1-c1ccc(CCc2ncc(-c3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1082041	6352	None	0	Mouse	Functional	pEC50	=	6.1	6.1	5	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	368	6	2	2	5.2	O=C(O)c1ccccc1-c1ccc(CCc2ncc(-c3ccccc3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	71451991	82818	None	0	Human	Functional	pEC50	=	7.1	7.1	15	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	477	2	2	5	5.6	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1	10.1021/ml200207w
	CHEMBL2179916	82818	None	0	Human	Functional	pEC50	=	7.1	7.1	15	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	477	2	2	5	5.6	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1	10.1021/ml200207w
	46881602	9077	None	0	Human	Functional	pEC50	=	7.1	7.1	-15	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	402	7	2	2	6.1	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1099033	9077	None	0	Human	Functional	pEC50	=	7.1	7.1	-15	2	Agonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at human BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	402	7	2	2	6.1	O=C(O)c1ccccc1-c1ccc(CCc2ncc(CC3CCCCCC3)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46884662	7824	None	0	Human	Functional	pEC50	=	7.1	7.1	-6	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089522	7824	None	0	Human	Functional	pEC50	=	7.1	7.1	-6	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884687	8174	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091917	8174	None	0	Human	Functional	pEC50	=	7.1	7.1	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	62707365	81908	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-11	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	4	2	8	6.0	C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164582	81908	None	0	Mouse	Functional	pEC50	=	7.1	7.1	-11	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	573	4	2	8	6.0	C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	46887826	8583	None	0	Rat	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	322	3	2	5	2.2	CN(C)c1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2	10.1016/j.bmcl.2010.03.065
	CHEMBL1094728	8583	None	0	Rat	Functional	pEC50	=	5.1	5.1	1	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	322	3	2	5	2.2	CN(C)c1nc2[nH]nc(N)c2c2c1CN(Cc1ccccc1)CC2	10.1016/j.bmcl.2010.03.065
	25025862	7823	None	0	Mouse	Functional	pEC50	=	8.1	8.1	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089521	7823	None	0	Mouse	Functional	pEC50	=	8.1	8.1	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46881471	6463	None	0	Mouse	Functional	pEC50	=	8.0	8.0	13	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1082543	6463	None	0	Mouse	Functional	pEC50	=	8.0	8.0	13	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	396	7	2	2	5.5	Cc1ccccc1Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	44300413	100780	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	538	9	6	4	3.0	O=C(CC1NCCc2ccccc21)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	CHEMBL292646	100780	None	0	Human	Functional	pEC50	=	8.0	8.0	-	1	Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.Effective concentration required against human bombesin receptor 3 (BRS-3) in CHO cells by using FLIPR assay.	ChEMBL	538	9	6	4	3.0	O=C(CC1NCCc2ccccc21)NNC(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1	10.1021/jm0210921
	46881510	7616	None	0	Mouse	Functional	pEC50	=	8.0	8.0	18	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3F)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	CHEMBL1088062	7616	None	0	Mouse	Functional	pEC50	=	8.0	8.0	18	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	400	7	2	2	5.3	O=C(O)c1ccccc1-c1ccc(CCc2ncc(Cc3ccccc3F)[nH]2)cc1	10.1016/j.bmcl.2010.01.154
	46845425	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	8504	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1089721	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	46845425	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	8504	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	CHEMBL1089721	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonist activity at mouse BRS3Agonist activity at mouse BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	46845425	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.01.154
	8504	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.01.154
	CHEMBL1089721	1032	None	2	Mouse	Functional	pEC50	=	8.0	8.0	-1	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.01.154
	46885313	8104	None	0	Mouse	Functional	pEC50	=	7.1	7.1	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091554	8104	None	0	Mouse	Functional	pEC50	=	7.1	7.1	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	54586335	60854	None	0	Mouse	Functional	pEC50	=	7.1	7.1	12	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762254	60854	None	0	Mouse	Functional	pEC50	=	7.1	7.1	12	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	46884627	8379	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093170	8379	None	0	Mouse	Functional	pEC50	=	7.0	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884663	7825	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089523	7825	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618753	81907	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-14	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	559	4	2	8	5.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1	10.1021/ml200304j
	CHEMBL2164581	81907	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-14	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	559	4	2	8	5.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1	10.1021/ml200304j
	46881961	5833	None	0	Mouse	Functional	pEC50	=	7.0	7.0	28	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	348	8	2	2	4.9	CCCCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079114	5833	None	0	Mouse	Functional	pEC50	=	7.0	7.0	28	2	Agonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assayAgonistic activity at mouse BRS3 expressed in HEK293AEO cells by aequorin bioluminescence assay	ChEMBL	348	8	2	2	4.9	CCCCc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	46845425	1032	None	2	Mouse	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	8504	1032	None	2	Mouse	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1089721	1032	None	2	Mouse	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	11891917	60846	None	0	Human	Functional	pEC50	=	6.0	6.0	-8	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762246	60846	None	0	Human	Functional	pEC50	=	6.0	6.0	-8	2	Agonist activity at human BRS3 by functional assayAgonist activity at human BRS3 by functional assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46885312	8103	None	0	Human	Functional	pEC50	=	7.0	7.0	-10	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091553	8103	None	0	Human	Functional	pEC50	=	7.0	7.0	-10	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884578	8182	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091984	8182	None	0	Human	Functional	pEC50	=	7.0	7.0	-3	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884629	8381	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093183	8381	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25134006	81821	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-11	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	599	4	2	8	5.8	CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164225	81821	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-11	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	599	4	2	8	5.8	CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	46885311	8317	None	0	Mouse	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092730	8317	None	0	Mouse	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	59618658	82698	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179481	82698	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46887765	8659	None	0	Rat	Functional	pEC50	=	6.0	6.0	10	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	348	3	2	5	2.7	Nc1n[nH]c2nc(N3CCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1095424	8659	None	0	Rat	Functional	pEC50	=	6.0	6.0	10	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	348	3	2	5	2.7	Nc1n[nH]c2nc(N3CCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	46884628	8255	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092381	8255	None	0	Human	Functional	pEC50	=	7.0	7.0	-1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25025861	8382	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093184	8382	None	0	Human	Functional	pEC50	=	7.0	7.0	1	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	56840673	1141	None	0	Human	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	8503	1141	None	0	Human	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	CHEMBL2164575	1141	None	0	Human	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at human BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	46885312	8103	None	0	Mouse	Functional	pEC50	=	7.0	7.0	10	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091553	8103	None	0	Mouse	Functional	pEC50	=	7.0	7.0	10	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884577	8114	None	0	Mouse	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091599	8114	None	0	Mouse	Functional	pEC50	=	7.0	7.0	2	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884576	8113	None	0	Human	Functional	pEC50	=	7.0	7.0	-4	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091598	8113	None	0	Human	Functional	pEC50	=	7.0	7.0	-4	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	46884577	8114	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091599	8114	None	0	Human	Functional	pEC50	=	7.0	7.0	-2	2	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	11891917	60846	None	0	Mouse	Functional	pEC50	=	7.0	7.0	8	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762246	60846	None	0	Mouse	Functional	pEC50	=	7.0	7.0	8	2	Agonist activity at mouse BRS3 by functional assayAgonist activity at mouse BRS3 by functional assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	59618709	82809	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-14	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	455	2	1	4	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2	10.1021/ml200207w
	CHEMBL2179908	82809	None	0	Mouse	Functional	pEC50	=	7.0	7.0	-14	2	Agonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assayAgonist activity at mouse BRS3 expressed in HEK293 cells expressing aequorin measured for 30 secs by bioluminescence assay	ChEMBL	455	2	1	4	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2	10.1021/ml200207w
	25025860	569	None	23	Human	Functional	pEC50	=	7	7.0	-14	5	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	6188	569	None	23	Human	Functional	pEC50	=	7	7.0	-14	5	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1091720	569	None	23	Human	Functional	pEC50	=	7	7.0	-14	5	Agonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at human BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	46884687	8174	None	0	Mouse	Functional	pEC50	=	7	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091917	8174	None	0	Mouse	Functional	pEC50	=	7	7.0	3	2	Agonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesinAgonist activity at mouse BRS-3 expressed in HEK293 cells coexpressing AEQ over 10 mins by aequorin bioluminescence assay relative to D-Tyr6-betaAla11-Phe13-Nle14-bombesin	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	62707207	81822	None	0	Mouse	Functional	pEC50	=	7	7.0	-5	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	597	6	2	9	5.4	CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164226	81822	None	0	Mouse	Functional	pEC50	=	7	7.0	-5	2	Agonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assayAgonist activity at mouse BRS-3 expressed in HEK293AEQ cells assessed as bioluminescence for 10 mins by aequorin bioluminescence assay	ChEMBL	597	6	2	9	5.4	CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	46887982	8746	None	0	Rat	Functional	pEC50	=	7	7.0	47	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	432	5	2	5	4.1	CC(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	CHEMBL1096193	8746	None	0	Rat	Functional	pEC50	=	7	7.0	47	2	Agonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assayAgonist activity at rat BRS3 expressed in HEK293AEQ cells after 10 mins by aequorin bioluminescence assay	ChEMBL	432	5	2	5	4.1	CC(C)C(=O)Nc1n[nH]c2nc(N3CCCCC3)c3c(c12)CCN(Cc1ccccc1)C3	10.1016/j.bmcl.2010.03.065
	132427043	195579	None	3	Mouse	Functional	pIC50	=	8.8	8.8	-1	3	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Mouse	Functional	pIC50	=	8.8	8.8	-1	3	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	49871766	2557	None	36	Human	Functional	pIC50	=	7.0	7.0	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Human	Functional	pIC50	=	7.0	7.0	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Human	Functional	pIC50	=	7.0	7.0	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	123695309	196718	None	0	Human	Functional	pIC50	=	7.9	7.9	-4	2	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5430646	196718	None	0	Human	Functional	pIC50	=	7.9	7.9	-4	2	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	49871766	2557	None	36	Mouse	Functional	pIC50	=	7.7	7.7	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Mouse	Functional	pIC50	=	7.7	7.7	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Mouse	Functional	pIC50	=	7.7	7.7	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	132427043	195579	None	3	Human	Functional	pIC50	=	8.6	8.6	-2	3	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Human	Functional	pIC50	=	8.6	8.6	-2	3	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	49871766	2557	None	36	Human	Functional	pIC50	=	7.6	7.6	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Human	Functional	pIC50	=	7.6	7.6	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Human	Functional	pIC50	=	7.6	7.6	-6	5	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	123695309	196718	None	0	Mouse	Functional	pIC50	=	8.4	8.4	4	2	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5430646	196718	None	0	Mouse	Functional	pIC50	=	8.4	8.4	4	2	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	132427043	195579	None	3	Mouse	Functional	pIC50	=	7.5	7.5	-1	3	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Mouse	Functional	pIC50	=	7.5	7.5	-1	3	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	49871766	2557	None	36	Mouse	Functional	pIC50	=	8.4	8.4	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	6170	2557	None	36	Mouse	Functional	pIC50	=	8.4	8.4	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	CHEMBL1672354	2557	None	36	Mouse	Functional	pIC50	=	8.4	8.4	-3	5	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced intracellular calcium response by measuring Bantag-1 pIC50 preincubated for 10 mins with Bantag-1 followed by compound addition and measured for 3 mins by FLIPR calcium 6 assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/acs.jmedchem.3c00323
	123695309	196718	None	0	Mouse	Functional	pIC50	=	8.2	8.2	4	2	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5430646	196718	None	0	Mouse	Functional	pIC50	=	8.2	8.2	4	2	Agonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at mouse BB3 stably overexpressed in human HEK cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	123695309	196718	None	0	Human	Functional	pIC50	=	7.2	7.2	-4	2	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5430646	196718	None	0	Human	Functional	pIC50	=	7.2	7.2	-4	2	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	346	5	3	7	3.0	COc1cc(C(O)CC=C(C)C)c(OC)c2c1/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	132427043	195579	None	3	Human	Functional	pIC50	=	7.1	7.1	-2	3	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	CHEMBL5406411	195579	None	3	Human	Functional	pIC50	=	7.1	7.1	-2	3	Agonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assayAgonist activity at human BB3 stably overexpressed in human NCI-H1299 cells assessed as blockade of compound induced IP-1 accumulation by measuring Bantag-1 pIC50 in presence of Bantag-1 incubated for 60 mins by HTRF assay	ChEMBL	440	7	2	9	4.3	C=CC(C)(C)C(OC(=O)c1ccco1)c1cc(OC)c2c(c1OC)/C(=N/O)C=C/C2=N\O	10.1021/acs.jmedchem.3c00323
	11261	1155	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	2	In a Ca aequorin assay.In a Ca aequorin assay.	Guide to Pharmacology	428	4	1	3	5.0	COc1ccc2c(c1)C(=O)N(Cc1ccccc1)C(c1c2cccc1)C(=O)NC(C)(C)C	28324017
	154733031	1155	None	0	Human	Functional	pEC50	=	6.6	6.6	-2	2	In a Ca aequorin assay.In a Ca aequorin assay.	Guide to Pharmacology	428	4	1	3	5.0	COc1ccc2c(c1)C(=O)N(Cc1ccccc1)C(c1c2cccc1)C(=O)NC(C)(C)C	28324017
	11261	1155	None	0	Rat	Functional	pEC50	=	7	7.0	2	2	In a Ca aequorin assay.In a Ca aequorin assay.	Guide to Pharmacology	428	4	1	3	5.0	COc1ccc2c(c1)C(=O)N(Cc1ccccc1)C(c1c2cccc1)C(=O)NC(C)(C)C	28324017
	154733031	1155	None	0	Rat	Functional	pEC50	=	7	7.0	2	2	In a Ca aequorin assay.In a Ca aequorin assay.	Guide to Pharmacology	428	4	1	3	5.0	COc1ccc2c(c1)C(=O)N(Cc1ccccc1)C(c1c2cccc1)C(=O)NC(C)(C)C	28324017
	10569	2837	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	145996512	2837	None	0	Human	Functional	pEC50	=	5.7	5.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	31675498
	6192	3097	None	0	Rat	Functional	pEC50	=	7.0	7.0	-3	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	19580790
	73755184	3097	None	0	Rat	Functional	pEC50	=	7.0	7.0	-3	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	19580790
	6191	264	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15635635
	6191	264	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18006692
	6191	264	None	0	Human	Functional	pEC50	=	7.3	7.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20438784
	6192	3097	None	0	Mouse	Functional	pEC50	=	7.5	7.5	3	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	19580790
	73755184	3097	None	0	Mouse	Functional	pEC50	=	7.5	7.5	3	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	19580790
	49871766	2557	None	36	Human	Functional	pEC50	=	7.6	7.6	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	6170	2557	None	36	Human	Functional	pEC50	=	7.6	7.6	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	CHEMBL1672354	2557	None	36	Human	Functional	pEC50	=	7.6	7.6	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	8508	1150	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	479	8	2	5	4.5	CC(CCOc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	24412111
	91827365	1150	None	0	Human	Functional	pEC50	=	7.8	7.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology	479	8	2	5	4.5	CC(CCOc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	24412111
	8507	1002	None	0	Human	Functional	pEC50	=	7.9	7.9	3	2	UnclassifiedUnclassified	Guide to Pharmacology	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	25497965
	91827364	1002	None	0	Human	Functional	pEC50	=	7.9	7.9	3	2	UnclassifiedUnclassified	Guide to Pharmacology	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	25497965
	CHEMBL3356404	1002	None	0	Human	Functional	pEC50	=	7.9	7.9	3	2	UnclassifiedUnclassified	Guide to Pharmacology	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	25497965
	6192	3097	None	0	Human	Functional	pEC50	=	8.4	8.4	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	12212809
	6192	3097	None	0	Human	Functional	pEC50	=	8.4	8.4	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	19580790
	73755184	3097	None	0	Human	Functional	pEC50	=	8.4	8.4	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	12212809
	73755184	3097	None	0	Human	Functional	pEC50	=	8.4	8.4	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	19580790
	72944991	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	24412111
	72944991	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	26524625
	72944991	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	35644465
	8509	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	24412111
	8509	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	26524625
	8509	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	35644465
	CHEMBL3115390	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	24412111
	CHEMBL3115390	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	26524625
	CHEMBL3115390	1151	None	0	Human	Functional	pEC50	=	8.8	8.8	2	2	UnclassifiedUnclassified	Guide to Pharmacology	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	35644465
	10254379	1026	None	0	Human	Functional	pEC50	None	9.7	9.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	475	9	5	3	4.4	O=C(N[C@@H](C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NNc1ccc(cc1)Cl	12723954
	630	1026	None	0	Human	Functional	pEC50	None	9.7	9.7	-	1	UnclassifiedUnclassified	Guide to Pharmacology	475	9	5	3	4.4	O=C(N[C@@H](C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NNc1ccc(cc1)Cl	12723954
	6192	3097	None	0	Human	Functional	pIC50	=	5.3	5.3	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	20438784
	73755184	3097	None	0	Human	Functional	pIC50	=	5.3	5.3	-4	3	UnclassifiedUnclassified	Guide to Pharmacology	482	10	4	3	3.4	CC(C(=O)NC(C(=O)NCCc1ccccc1)Cc1c[nH]c2c1cccc2)NC(=O)c1ccccc1	20438784
	8505	2567	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology	569	10	4	5	5.8	COc1ccc(cc1)C1(CCCCC1)CNC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)Nc1ccc(cc1)[N+](=O)[O-]	25554218
	91827363	2567	None	0	Human	Functional	pIC50	=	5.3	5.3	-	1	UnclassifiedUnclassified	Guide to Pharmacology	569	10	4	5	5.8	COc1ccc(cc1)C1(CCCCC1)CNC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)Nc1ccc(cc1)[N+](=O)[O-]	25554218
	6191	264	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18006692
	6191	264	None	0	Human	Functional	pIC50	=	6.8	6.8	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20438784
	25025654	570	None	12	Human	Functional	pIC50	=	7.0	7.0	-15	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	6189	570	None	12	Human	Functional	pIC50	=	7.0	7.0	-15	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	8506	570	None	12	Human	Functional	pIC50	=	7.0	7.0	-15	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	CHEMBL1084942	570	None	12	Human	Functional	pIC50	=	7.0	7.0	-15	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	49871766	2557	None	36	Human	Functional	pIC50	=	7.2	7.2	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	23892571
	49871766	2557	None	36	Human	Functional	pIC50	=	7.2	7.2	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	6170	2557	None	36	Human	Functional	pIC50	=	7.2	7.2	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	23892571
	6170	2557	None	36	Human	Functional	pIC50	=	7.2	7.2	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	CHEMBL1672354	2557	None	36	Human	Functional	pIC50	=	7.2	7.2	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	23892571
	CHEMBL1672354	2557	None	36	Human	Functional	pIC50	=	7.2	7.2	-6	5	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	46845425	1032	None	2	Human	Functional	pIC50	=	7.6	7.6	1	2	UnclassifiedUnclassified	Guide to Pharmacology	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	20167483
	8504	1032	None	2	Human	Functional	pIC50	=	7.6	7.6	1	2	UnclassifiedUnclassified	Guide to Pharmacology	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	20167483
	CHEMBL1089721	1032	None	2	Human	Functional	pIC50	=	7.6	7.6	1	2	UnclassifiedUnclassified	Guide to Pharmacology	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	20167483
	25025860	569	None	23	Human	Functional	pIC50	=	7.7	7.7	-14	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	6188	569	None	23	Human	Functional	pIC50	=	7.7	7.7	-14	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	CHEMBL1091720	569	None	23	Human	Functional	pIC50	=	7.7	7.7	-14	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	633	1505	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18006692
	633	1505	None	0	Human	Functional	pIC50	=	8.0	8.0	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20438784
	25025654	570	None	12	Rat	Functional	pIC50	=	8.0	8.0	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	6189	570	None	12	Rat	Functional	pIC50	=	8.0	8.0	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	8506	570	None	12	Rat	Functional	pIC50	=	8.0	8.0	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	CHEMBL1084942	570	None	12	Rat	Functional	pIC50	=	8.0	8.0	-1	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	6176	573	None	0	Mouse	Functional	pIC50	=	8.1	8.1	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	20096642
	73755180	573	None	0	Mouse	Functional	pIC50	=	8.1	8.1	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	20096642
	3946	1503	None	0	Human	Functional	pIC50	=	8.1	8.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	18006692
	3946	1503	None	0	Human	Functional	pIC50	=	8.1	8.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	20438784
	25025860	569	None	23	Mouse	Functional	pIC50	=	8.2	8.2	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	6188	569	None	23	Mouse	Functional	pIC50	=	8.2	8.2	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	CHEMBL1091720	569	None	23	Mouse	Functional	pIC50	=	8.2	8.2	-4	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	25025654	570	None	12	Mouse	Functional	pIC50	=	8.2	8.2	1	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	6189	570	None	12	Mouse	Functional	pIC50	=	8.2	8.2	1	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	8506	570	None	12	Mouse	Functional	pIC50	=	8.2	8.2	1	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	CHEMBL1084942	570	None	12	Mouse	Functional	pIC50	=	8.2	8.2	1	3	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	46200989	2562	None	14	Human	Functional	pIC50	=	8.5	8.5	9	2	UnclassifiedUnclassified	Guide to Pharmacology	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	24900461
	8502	2562	None	14	Human	Functional	pIC50	=	8.5	8.5	9	2	UnclassifiedUnclassified	Guide to Pharmacology	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	24900461
	CHEMBL2023109	2562	None	14	Human	Functional	pIC50	=	8.5	8.5	9	2	UnclassifiedUnclassified	Guide to Pharmacology	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	24900461
	25025860	569	None	23	Rat	Functional	pIC50	=	8.6	8.6	4	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	6188	569	None	23	Rat	Functional	pIC50	=	8.6	8.6	4	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	CHEMBL1091720	569	None	23	Rat	Functional	pIC50	=	8.6	8.6	4	5	UnclassifiedUnclassified	Guide to Pharmacology	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	20096642
	6176	573	None	0	Human	Functional	pIC50	=	8.7	8.7	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	20096642
	6176	573	None	0	Human	Functional	pIC50	=	8.7	8.7	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	23892571
	6176	573	None	0	Human	Functional	pIC50	=	8.7	8.7	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	30971479
	73755180	573	None	0	Human	Functional	pIC50	=	8.7	8.7	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	20096642
	73755180	573	None	0	Human	Functional	pIC50	=	8.7	8.7	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	23892571
	73755180	573	None	0	Human	Functional	pIC50	=	8.7	8.7	-1	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	30971479
	6176	573	None	0	Rat	Functional	pIC50	=	8.8	8.8	1	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	20096642
	73755180	573	None	0	Rat	Functional	pIC50	=	8.8	8.8	1	5	UnclassifiedUnclassified	Guide to Pharmacology	895	23	7	8	4.8	CC(C[C@@H](C(=O)NCC1=CCCC(=C1)C[N+](C)(C)C)NC(=O)C[C@@H]([C@@H](NC([C@@H](N(C(=O)[C@H](CC1=CC=CCC1)NC(=O)OC(C)(C)C)C)Cc1c[nH]c[nH+]1)O)CC1CCCCC1)O)C	20096642
	56840673	1141	None	0	Human	Functional	pIC50	=	8.9	8.9	2	2	UnclassifiedUnclassified	Guide to Pharmacology	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	24900283
	8503	1141	None	0	Human	Functional	pIC50	=	8.9	8.9	2	2	UnclassifiedUnclassified	Guide to Pharmacology	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	24900283
	CHEMBL2164575	1141	None	0	Human	Functional	pIC50	=	8.9	8.9	2	2	UnclassifiedUnclassified	Guide to Pharmacology	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	24900283
	635	1450	None	0	Human	Functional	pIC50	None	5.6	5.6	-6	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9325344
	635	1450	None	0	Human	Functional	pIC50	None	5.6	5.6	-6	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9593699
	635	1450	None	0	Human	Functional	pIC50	None	5.6	5.6	-6	4	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9765358

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Ligands (move mouse cursor over ligand name to see structure)					Receptor	Activity									Chemical information
Sel. page	Common name	GPCRdb ID	Reference ligand	Vendors	Species	Assay Type	Activity Type	Activity Relation	Activity Value	p-value (-log)	Fold selectivity	Tested GPCRs	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	155511392	169651	None	0	Mouse	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	516	10	2	5	6.5	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCOc1cccc(O)c1	10.1016/j.bmcl.2016.07.056
	CHEMBL4435571	169651	None	0	Mouse	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	516	10	2	5	6.5	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCOc1cccc(O)c1	10.1016/j.bmcl.2016.07.056
	155511392	169651	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	516	10	2	5	6.5	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCOc1cccc(O)c1	10.1016/j.bmcl.2016.07.056
	CHEMBL4435571	169651	None	0	Human	Binding	pEC50	=	9.1	9.1	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	516	10	2	5	6.5	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCOc1cccc(O)c1	10.1016/j.bmcl.2016.07.056
	155528415	171430	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	466	9	1	5	5.3	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4461212	171430	None	0	Human	Binding	pEC50	=	9	9.0	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	466	9	1	5	5.3	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	76314247	105349	None	0	Mouse	Binding	pEC50	=	9	9.0	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	441	4	1	4	5.2	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115400	105349	None	0	Mouse	Binding	pEC50	=	9	9.0	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	441	4	1	4	5.2	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1	10.1016/j.bmcl.2013.12.106
	76314247	105349	None	0	Mouse	Binding	pEC50	=	9	9.0	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	441	4	1	4	5.2	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1	10.1016/j.bmc.2014.11.018
	CHEMBL3115400	105349	None	0	Mouse	Binding	pEC50	=	9	9.0	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	441	4	1	4	5.2	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1	10.1016/j.bmc.2014.11.018
	76314247	105349	None	0	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	441	4	1	4	5.2	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115400	105349	None	0	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	441	4	1	4	5.2	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1	10.1016/j.bmcl.2013.12.106
	76314247	105349	None	0	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	441	4	1	4	5.2	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1	10.1016/j.bmc.2014.11.018
	CHEMBL3115400	105349	None	0	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	441	4	1	4	5.2	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cc1	10.1016/j.bmc.2014.11.018
	46200989	2562	None	14	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmcl.2013.12.106
	8502	2562	None	14	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmcl.2013.12.106
	CHEMBL2023109	2562	None	14	Human	Binding	pEC50	=	8.9	8.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmcl.2013.12.106
	76321532	105335	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115386	105335	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	76321532	105335	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115386	105335	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	72944991	1151	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmcl.2013.12.106
	8509	1151	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmcl.2013.12.106
	CHEMBL3115390	1151	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmcl.2013.12.106
	76328698	105337	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	503	6	2	5	5.0	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115388	105337	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	503	6	2	5	5.0	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1	10.1016/j.bmcl.2013.12.106
	72944991	1151	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmc.2014.11.018
	8509	1151	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmc.2014.11.018
	CHEMBL3115390	1151	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmc.2014.11.018
	76328698	105337	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	503	6	2	5	5.0	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115388	105337	None	0	Human	Binding	pEC50	=	8.8	8.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	503	6	2	5	5.0	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1	10.1016/j.bmc.2014.11.018
	76317821	105329	None	0	Mouse	Binding	pEC50	=	7	7.0	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	419	4	1	4	4.4	O=C(Cc1cccc(OC2CCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115380	105329	None	0	Mouse	Binding	pEC50	=	7	7.0	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	419	4	1	4	4.4	O=C(Cc1cccc(OC2CCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76336000	105320	None	0	Mouse	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2cccnc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115371	105320	None	0	Mouse	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2cccnc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76328696	105333	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	471	6	2	5	4.8	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CCO	10.1016/j.bmcl.2013.12.106
	CHEMBL3115384	105333	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	471	6	2	5	4.8	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CCO	10.1016/j.bmcl.2013.12.106
	155521672	170753	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	452	9	2	4	5.2	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCC(=O)O	10.1016/j.bmcl.2016.07.056
	CHEMBL4451347	170753	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	452	9	2	4	5.2	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCC(=O)O	10.1016/j.bmcl.2016.07.056
	155530555	171637	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	515	10	1	6	4.4	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCNS(C)(=O)=O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4464287	171637	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	515	10	1	6	4.4	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCNS(C)(=O)=O)cc1	10.1016/j.bmcl.2016.07.056
	76328696	105333	None	0	Mouse	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	471	6	2	5	4.8	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CCO	10.1016/j.bmcl.2013.12.106
	CHEMBL3115384	105333	None	0	Mouse	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	471	6	2	5	4.8	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CCO	10.1016/j.bmcl.2013.12.106
	76325133	105331	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	457	5	2	5	4.4	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CO	10.1016/j.bmcl.2013.12.106
	CHEMBL3115382	105331	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	457	5	2	5	4.4	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CO	10.1016/j.bmcl.2013.12.106
	8507	1002	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	10.1016/j.bmc.2014.11.018
	91827364	1002	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	10.1016/j.bmc.2014.11.018
	CHEMBL3356404	1002	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	10.1016/j.bmc.2014.11.018
	155543657	173306	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	514	9	2	4	6.5	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1Cc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4522752	173306	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	514	9	2	4	6.5	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1Cc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	76325135	105343	None	0	Mouse	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	427	4	1	4	4.9	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115395	105343	None	0	Mouse	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	427	4	1	4	4.9	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76325135	105343	None	0	Mouse	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	427	4	1	4	4.9	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmc.2014.11.018
	CHEMBL3115395	105343	None	0	Mouse	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	427	4	1	4	4.9	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmc.2014.11.018
	76332372	105324	None	0	Mouse	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	379	4	1	4	3.5	CCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115375	105324	None	0	Mouse	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	379	4	1	4	3.5	CCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76336002	105328	None	0	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	421	4	1	4	4.5	CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115379	105328	None	0	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	421	4	1	4	4.5	CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76336002	105328	None	0	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	421	4	1	4	4.5	CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115379	105328	None	0	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	421	4	1	4	4.5	CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	155568183	176147	None	0	Mouse	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	420	8	2	4	4.7	CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	CHEMBL4590481	176147	None	0	Mouse	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	420	8	2	4	4.7	CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	76328697	105334	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115385	105334	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	76328697	105334	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115385	105334	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	155554592	174727	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	530	10	1	6	6.6	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCOc2cccc(O)c2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4557722	174727	None	0	Human	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	530	10	1	6	6.6	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCOc2cccc(O)c2)cc1	10.1016/j.bmcl.2016.07.056
	155543657	173306	None	0	Mouse	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	514	9	2	4	6.5	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1Cc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4522752	173306	None	0	Mouse	Binding	pEC50	=	7.9	7.9	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	514	9	2	4	6.5	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1Cc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	46200989	2562	None	14	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2014.11.018
	8502	2562	None	14	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2014.11.018
	CHEMBL2023109	2562	None	14	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2014.11.018
	76332370	105318	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	484	5	1	4	5.6	CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115369	105318	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	484	5	1	4	5.6	CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1	10.1016/j.bmcl.2013.12.106
	76332370	105318	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	484	5	1	4	5.6	CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115369	105318	None	0	Human	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	484	5	1	4	5.6	CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1	10.1016/j.bmc.2014.11.018
	76336003	105344	None	0	Mouse	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	3	2	4	5.4	O=C(Nc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115396	105344	None	0	Mouse	Binding	pEC50	=	5.9	5.9	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	3	2	4	5.4	O=C(Nc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	49871766	2557	None	36	Human	Binding	pEC50	=	7.9	7.9	-9	3	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1016/j.bmc.2014.11.018
	6170	2557	None	36	Human	Binding	pEC50	=	7.9	7.9	-9	3	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1016/j.bmc.2014.11.018
	CHEMBL1672354	2557	None	36	Human	Binding	pEC50	=	7.9	7.9	-9	3	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1016/j.bmc.2014.11.018
	155538227	172469	None	0	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	438	8	2	4	4.8	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	CHEMBL4476111	172469	None	0	Mouse	Binding	pEC50	=	6.9	6.9	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	438	8	2	4	4.8	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	76328697	105334	None	0	Mouse	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115385	105334	None	0	Mouse	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	76328697	105334	None	0	Mouse	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115385	105334	None	0	Mouse	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)CC1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	76336000	105320	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2cccnc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115371	105320	None	0	Human	Binding	pEC50	=	6.8	6.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2cccnc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76321531	105332	None	0	Human	Binding	pEC50	=	5.8	5.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	471	5	2	5	4.5	O=C(O)C1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115383	105332	None	0	Human	Binding	pEC50	=	5.8	5.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	471	5	2	5	4.5	O=C(O)C1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	76325134	105338	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	465	7	2	5	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115389	105338	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	465	7	2	5	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmcl.2013.12.106
	76325134	105338	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	465	7	2	5	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115389	105338	None	0	Human	Binding	pEC50	=	7.8	7.8	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	465	7	2	5	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76317820	105323	None	0	Mouse	Binding	pEC50	=	5.8	5.8	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	365	3	1	4	3.1	COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115374	105323	None	0	Mouse	Binding	pEC50	=	5.8	5.8	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	365	3	1	4	3.1	COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	118721523	116136	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	8	2	6	4.2	CCCCC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356405	116136	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	8	2	6	4.2	CCCCC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76325133	105331	None	0	Mouse	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	457	5	2	5	4.4	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CO	10.1016/j.bmcl.2013.12.106
	CHEMBL3115382	105331	None	0	Mouse	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	457	5	2	5	4.4	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1CO	10.1016/j.bmcl.2013.12.106
	155541223	173103	None	0	Mouse	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	391	9	1	4	4.8	CCC(C)(C)Cc1cn(CC(=O)O)c(CCc2ccc(-c3ccccn3)cc2)n1	10.1016/j.bmcl.2016.07.056
	CHEMBL4518142	173103	None	0	Mouse	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	391	9	1	4	4.8	CCC(C)(C)Cc1cn(CC(=O)O)c(CCc2ccc(-c3ccccn3)cc2)n1	10.1016/j.bmcl.2016.07.056
	76336002	105328	None	0	Human	Binding	pEC50	=	6.7	6.7	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	421	4	1	4	4.5	CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115379	105328	None	0	Human	Binding	pEC50	=	6.7	6.7	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	421	4	1	4	4.5	CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76336002	105328	None	0	Human	Binding	pEC50	=	6.7	6.7	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	421	4	1	4	4.5	CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115379	105328	None	0	Human	Binding	pEC50	=	6.7	6.7	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	421	4	1	4	4.5	CC(C)(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	155519281	170542	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	501	10	2	5	4.3	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCNS(C)(=O)=O	10.1016/j.bmcl.2016.07.056
	CHEMBL4448589	170542	None	0	Human	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	501	10	2	5	4.3	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCNS(C)(=O)=O	10.1016/j.bmcl.2016.07.056
	155561529	175734	None	0	Mouse	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	424	8	2	4	4.8	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCO	10.1016/j.bmcl.2016.07.056
	CHEMBL4580739	175734	None	0	Mouse	Binding	pEC50	=	8.7	8.7	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	424	8	2	4	4.8	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCO	10.1016/j.bmcl.2016.07.056
	76328698	105337	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	503	6	2	5	5.0	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115388	105337	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	503	6	2	5	5.0	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1	10.1016/j.bmcl.2013.12.106
	76336005	105347	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115399	105347	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76328698	105337	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	503	6	2	5	5.0	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115388	105337	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	503	6	2	5	5.0	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccc(F)cc2)c1	10.1016/j.bmc.2014.11.018
	76336005	105347	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmc.2014.11.018
	CHEMBL3115399	105347	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmc.2014.11.018
	76325132	105322	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	442	4	1	5	4.6	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115373	105322	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	442	4	1	5	4.6	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1	10.1016/j.bmcl.2013.12.106
	76325132	105322	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	442	4	1	5	4.6	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1	10.1016/j.bmc.2014.11.018
	CHEMBL3115373	105322	None	0	Mouse	Binding	pEC50	=	8.6	8.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	442	4	1	5	4.6	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1	10.1016/j.bmc.2014.11.018
	118721525	116138	None	0	Mouse	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	507	6	2	6	4.5	CC(C)(C)CC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356407	116138	None	0	Mouse	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	507	6	2	6	4.5	CC(C)(C)CC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76317820	105323	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	365	3	1	4	3.1	COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115374	105323	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	365	3	1	4	3.1	COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76332372	105324	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	379	4	1	4	3.5	CCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115375	105324	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	379	4	1	4	3.5	CCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76332373	105336	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115387	105336	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	76332373	105336	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115387	105336	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	155539847	172585	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	438	8	1	5	4.8	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCO)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4482945	172585	None	0	Human	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	438	8	1	5	4.8	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCO)cc1	10.1016/j.bmcl.2016.07.056
	49871766	2557	None	36	Mouse	Binding	pEC50	=	7.7	7.7	-2	3	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1016/j.bmc.2014.11.018
	6170	2557	None	36	Mouse	Binding	pEC50	=	7.7	7.7	-2	3	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1016/j.bmc.2014.11.018
	CHEMBL1672354	2557	None	36	Mouse	Binding	pEC50	=	7.7	7.7	-2	3	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1016/j.bmc.2014.11.018
	46200989	2562	None	14	Mouse	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmcl.2013.12.106
	8502	2562	None	14	Mouse	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmcl.2013.12.106
	CHEMBL2023109	2562	None	14	Mouse	Binding	pEC50	=	7.7	7.7	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmcl.2013.12.106
	155519753	170545	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	342	6	1	3	4.2	COC(=O)C(C)(C)c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4448645	170545	None	0	Human	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	342	6	1	3	4.2	COC(=O)C(C)(C)c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	76321531	105332	None	0	Mouse	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	471	5	2	5	4.5	O=C(O)C1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115383	105332	None	0	Mouse	Binding	pEC50	=	5.7	5.7	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	471	5	2	5	4.5	O=C(O)C1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	76317822	105340	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	439	2	1	3	6.2	CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115392	105340	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	439	2	1	3	6.2	CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1016/j.bmcl.2013.12.106
	76317822	105340	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	439	2	1	3	6.2	CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1016/j.bmc.2014.11.018
	CHEMBL3115392	105340	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	439	2	1	3	6.2	CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1016/j.bmc.2014.11.018
	155539847	172585	None	0	Mouse	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	438	8	1	5	4.8	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCO)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4482945	172585	None	0	Mouse	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	438	8	1	5	4.8	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCO)cc1	10.1016/j.bmcl.2016.07.056
	76317823	105350	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2ccccn2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115401	105350	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2ccccn2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76310619	105342	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmcl.2013.12.106
	CHEMBL3115394	105342	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmcl.2013.12.106
	76310619	105342	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmc.2014.11.018
	CHEMBL3115394	105342	None	0	Human	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmc.2014.11.018
	155554592	174727	None	0	Mouse	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	530	10	1	6	6.6	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCOc2cccc(O)c2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4557722	174727	None	0	Mouse	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	530	10	1	6	6.6	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCOc2cccc(O)c2)cc1	10.1016/j.bmcl.2016.07.056
	76317823	105350	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2ccccn2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115401	105350	None	0	Human	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2ccccn2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76328694	105319	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	322	3	0	2	4.1	CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C	10.1016/j.bmcl.2013.12.106
	CHEMBL3115370	105319	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	322	3	0	2	4.1	CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C	10.1016/j.bmcl.2013.12.106
	76328694	105319	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	322	3	0	2	4.1	CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C	10.1016/j.bmc.2014.11.018
	CHEMBL3115370	105319	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	322	3	0	2	4.1	CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C	10.1016/j.bmc.2014.11.018
	155520679	170599	None	0	Mouse	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	391	9	1	4	4.8	CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	CHEMBL4449347	170599	None	0	Mouse	Binding	pEC50	=	7.6	7.6	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	391	9	1	4	4.8	CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	118721522	116135	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	479	6	2	6	3.7	CC(C)C(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356403	116135	None	0	Mouse	Binding	pEC50	=	6.6	6.6	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	479	6	2	6	3.7	CC(C)C(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	155561529	175734	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	424	8	2	4	4.8	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCO	10.1016/j.bmcl.2016.07.056
	CHEMBL4580739	175734	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	424	8	2	4	4.8	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCO	10.1016/j.bmcl.2016.07.056
	155568881	176286	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	528	9	1	5	6.6	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2Cc2ccc(C(=O)O)cc2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4593256	176286	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	528	9	1	5	6.6	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2Cc2ccc(C(=O)O)cc2)cc1	10.1016/j.bmcl.2016.07.056
	155528415	171430	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	466	9	1	5	5.3	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4461212	171430	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	466	9	1	5	5.3	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	118721530	116142	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	491	7	2	6	3.7	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(C(=O)OCC2CC2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356412	116142	None	0	Human	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	491	7	2	6	3.7	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(C(=O)OCC2CC2)c1	10.1016/j.bmc.2014.11.018
	76321532	105335	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115386	105335	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	76321532	105335	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115386	105335	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	72944991	1151	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmcl.2013.12.106
	8509	1151	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmcl.2013.12.106
	CHEMBL3115390	1151	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmcl.2013.12.106
	76328699	105345	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccccc2F)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115397	105345	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccccc2F)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	72944991	1151	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmc.2014.11.018
	8509	1151	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmc.2014.11.018
	CHEMBL3115390	1151	None	0	Mouse	Binding	pEC50	=	8.5	8.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	500	6	2	6	4.6	OC(=O)C[C@H]1N(CCNc2c1ccc(n2)C(F)(F)F)C(=O)Cc1cccc(c1)Oc1ccc(nc1)C	10.1016/j.bmc.2014.11.018
	76336005	105347	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115399	105347	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76336005	105347	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmc.2014.11.018
	CHEMBL3115399	105347	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccc(F)cc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmc.2014.11.018
	118721530	116142	None	0	Mouse	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	491	7	2	6	3.7	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(C(=O)OCC2CC2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356412	116142	None	0	Mouse	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	491	7	2	6	3.7	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(C(=O)OCC2CC2)c1	10.1016/j.bmc.2014.11.018
	76332373	105336	None	0	Mouse	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115387	105336	None	0	Mouse	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmcl.2013.12.106
	76332373	105336	None	0	Mouse	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115387	105336	None	0	Mouse	Binding	pEC50	=	5.5	5.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	485	6	2	5	4.9	O=C(O)C[C@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(Oc2ccccc2)c1	10.1016/j.bmc.2014.11.018
	56840673	1141	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2013.12.106
	8503	1141	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2013.12.106
	CHEMBL2164575	1141	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2013.12.106
	56840673	1141	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmc.2014.11.018
	8503	1141	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmc.2014.11.018
	CHEMBL2164575	1141	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmc.2014.11.018
	76332370	105318	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	484	5	1	4	5.6	CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115369	105318	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	484	5	1	4	5.6	CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1	10.1016/j.bmcl.2013.12.106
	76332370	105318	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	484	5	1	4	5.6	CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115369	105318	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	484	5	1	4	5.6	CC(C)C1CN(Cc2ccccc2)c2ccccc2CN1C(=O)Nc1cccc(N2CCOCC2)c1	10.1016/j.bmc.2014.11.018
	118721523	116136	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	8	2	6	4.2	CCCCC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356405	116136	None	0	Mouse	Binding	pEC50	=	7.5	7.5	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	8	2	6	4.2	CCCCC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76314246	105341	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1ccc(Oc2ccccc2)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmcl.2013.12.106
	CHEMBL3115393	105341	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1ccc(Oc2ccccc2)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmcl.2013.12.106
	76314246	105341	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1ccc(Oc2ccccc2)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmc.2014.11.018
	CHEMBL3115393	105341	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1ccc(Oc2ccccc2)cc1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmc.2014.11.018
	76328695	105325	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	393	4	1	4	3.9	CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115376	105325	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	393	4	1	4	3.9	CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76328695	105325	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	393	4	1	4	3.9	CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115376	105325	None	0	Human	Binding	pEC50	=	6.4	6.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	393	4	1	4	3.9	CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	132538074	172933	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	452	8	1	5	4.9	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4514194	172933	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	452	8	1	5	4.9	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	118721529	116141	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	8	2	6	4.1	CCCCOC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356411	116141	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	8	2	6	4.1	CCCCOC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	155519281	170542	None	0	Mouse	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	501	10	2	5	4.3	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCNS(C)(=O)=O	10.1016/j.bmcl.2016.07.056
	CHEMBL4448589	170542	None	0	Mouse	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	501	10	2	5	4.3	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCNS(C)(=O)=O	10.1016/j.bmcl.2016.07.056
	118721528	116140	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	3.9	CC(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356410	116140	None	0	Human	Binding	pEC50	=	8.4	8.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	3.9	CC(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	118721527	116139	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	479	6	2	6	3.7	CC(C)OC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356409	116139	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	479	6	2	6	3.7	CC(C)OC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	155541223	173103	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	391	9	1	4	4.8	CCC(C)(C)Cc1cn(CC(=O)O)c(CCc2ccc(-c3ccccn3)cc2)n1	10.1016/j.bmcl.2016.07.056
	CHEMBL4518142	173103	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	391	9	1	4	4.8	CCC(C)(C)Cc1cn(CC(=O)O)c(CCc2ccc(-c3ccccn3)cc2)n1	10.1016/j.bmcl.2016.07.056
	76317821	105329	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	419	4	1	4	4.4	O=C(Cc1cccc(OC2CCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115380	105329	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	419	4	1	4	4.4	O=C(Cc1cccc(OC2CCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	118721524	116137	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	491	7	2	6	3.8	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(OC(=O)CC2CC2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356406	116137	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	491	7	2	6	3.8	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(OC(=O)CC2CC2)c1	10.1016/j.bmc.2014.11.018
	155520679	170599	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	391	9	1	4	4.8	CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	CHEMBL4449347	170599	None	0	Human	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	391	9	1	4	4.8	CCC(C)(C)Cc1cnc(CCc2ccc(-c3ccccn3)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	8507	1002	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	10.1016/j.bmc.2014.11.018
	91827364	1002	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	10.1016/j.bmc.2014.11.018
	CHEMBL3356404	1002	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	4.1	CC(CC(=O)Oc1cccc(c1)CC(=O)N1CCNc2c([C@H]1CC(=O)O)ccc(n2)C(F)(F)F)C	10.1016/j.bmc.2014.11.018
	76336003	105344	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	3	2	4	5.4	O=C(Nc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115396	105344	None	0	Human	Binding	pEC50	=	5.4	5.4	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	3	2	4	5.4	O=C(Nc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	132538074	172933	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	452	8	1	5	4.9	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4514194	172933	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	452	8	1	5	4.9	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	118721527	116139	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	479	6	2	6	3.7	CC(C)OC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356409	116139	None	0	Mouse	Binding	pEC50	=	7.4	7.4	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	479	6	2	6	3.7	CC(C)OC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76310619	105342	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmcl.2013.12.106
	CHEMBL3115394	105342	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmcl.2013.12.106
	76310619	105342	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmc.2014.11.018
	CHEMBL3115394	105342	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	475	4	1	4	6.7	O=C(Cc1cccc(Oc2ccccc2)c1)N1Cc2ccc(C(F)(F)F)nc2Nc2ccccc21	10.1016/j.bmc.2014.11.018
	76317822	105340	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	439	2	1	3	6.2	CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115392	105340	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	439	2	1	3	6.2	CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1016/j.bmcl.2013.12.106
	76317822	105340	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	439	2	1	3	6.2	CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1016/j.bmc.2014.11.018
	CHEMBL3115392	105340	None	0	Human	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	439	2	1	3	6.2	CC(C)(C)c1ccc(CC(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1016/j.bmc.2014.11.018
	155552947	174185	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	376	6	1	3	5.2	COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4544477	174185	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	376	6	1	3	5.2	COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	155568881	176286	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	528	9	1	5	6.6	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2Cc2ccc(C(=O)O)cc2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4593256	176286	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	528	9	1	5	6.6	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2Cc2ccc(C(=O)O)cc2)cc1	10.1016/j.bmcl.2016.07.056
	118721528	116140	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	3.9	CC(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356410	116140	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	7	2	6	3.9	CC(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	118721531	116143	None	0	Human	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	507	6	2	6	4.3	CC(C)(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356413	116143	None	0	Human	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	507	6	2	6	4.3	CC(C)(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	118721529	116141	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	8	2	6	4.1	CCCCOC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356411	116141	None	0	Mouse	Binding	pEC50	=	8.3	8.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	493	8	2	6	4.1	CCCCOC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76336001	105326	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	407	6	1	4	4.3	CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115377	105326	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	407	6	1	4	4.3	CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76336001	105326	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	407	6	1	4	4.3	CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115377	105326	None	0	Mouse	Binding	pEC50	=	7.3	7.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	407	6	1	4	4.3	CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	76328695	105325	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	393	4	1	4	3.9	CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115376	105325	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	393	4	1	4	3.9	CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76328695	105325	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	393	4	1	4	3.9	CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115376	105325	None	0	Mouse	Binding	pEC50	=	6.3	6.3	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	393	4	1	4	3.9	CC(C)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	76336001	105326	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	407	6	1	4	4.3	CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115377	105326	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	407	6	1	4	4.3	CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76336001	105326	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	407	6	1	4	4.3	CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115377	105326	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	407	6	1	4	4.3	CCCCOc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	76336004	105346	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2cccc(F)c2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115398	105346	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2cccc(F)c2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76328699	105345	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccccc2F)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115397	105345	None	0	Human	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2ccccc2F)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	155521672	170753	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	452	9	2	4	5.2	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCC(=O)O	10.1016/j.bmcl.2016.07.056
	CHEMBL4451347	170753	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	452	9	2	4	5.2	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CCC(=O)O	10.1016/j.bmcl.2016.07.056
	76310617	105327	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	407	5	1	4	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115378	105327	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	407	5	1	4	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76325134	105338	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	465	7	2	5	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115389	105338	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	465	7	2	5	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmcl.2013.12.106
	76310617	105327	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	407	5	1	4	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115378	105327	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	407	5	1	4	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	76325134	105338	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	465	7	2	5	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115389	105338	None	0	Mouse	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	465	7	2	5	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76332371	105321	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2ccncc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115372	105321	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2ccncc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	155515849	170103	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	358	7	1	4	4.1	COC(=O)C(C)(C)Oc1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4442362	170103	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	358	7	1	4	4.1	COC(=O)C(C)(C)Oc1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	155552947	174185	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	376	6	1	3	5.2	COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4544477	174185	None	0	Human	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	376	6	1	3	5.2	COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	118721522	116135	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	479	6	2	6	3.7	CC(C)C(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356403	116135	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	479	6	2	6	3.7	CC(C)C(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	155538227	172469	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	438	8	2	4	4.8	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	CHEMBL4476111	172469	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	438	8	2	4	4.8	CC(C)(C)Cc1cnc(CCc2ccc(-c3cccc(F)c3C(=O)O)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	155543793	173318	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	434	8	1	5	4.8	COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4522974	173318	None	0	Mouse	Binding	pEC50	=	6.2	6.2	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	434	8	1	5	4.8	COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	155530555	171637	None	0	Mouse	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	515	10	1	6	4.4	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCNS(C)(=O)=O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4464287	171637	None	0	Mouse	Binding	pEC50	=	8.2	8.2	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	515	10	1	6	4.4	COC(=O)c1c(F)cccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CCNS(C)(=O)=O)cc1	10.1016/j.bmcl.2016.07.056
	76310617	105327	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	407	5	1	4	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115378	105327	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	407	5	1	4	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmcl.2013.12.106
	76310617	105327	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	407	5	1	4	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3115378	105327	None	0	Human	Binding	pEC50	=	7.2	7.2	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	407	5	1	4	4.1	CC(C)COc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3C2)c1	10.1016/j.bmc.2014.11.018
	46200989	2562	None	14	Human	Binding	pEC50	=	7.1	7.1	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2014.11.018
	8502	2562	None	14	Human	Binding	pEC50	=	7.1	7.1	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2014.11.018
	CHEMBL2023109	2562	None	14	Human	Binding	pEC50	=	7.1	7.1	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2014.11.018
	76314245	105330	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	433	4	1	4	4.8	O=C(Cc1cccc(OC2CCCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115381	105330	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	433	4	1	4	4.8	O=C(Cc1cccc(OC2CCCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	118721531	116143	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	507	6	2	6	4.3	CC(C)(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356413	116143	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	507	6	2	6	4.3	CC(C)(C)COC(=O)c1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76325135	105343	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	427	4	1	4	4.9	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115395	105343	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	427	4	1	4	4.9	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76325135	105343	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	427	4	1	4	4.9	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmc.2014.11.018
	CHEMBL3115395	105343	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	427	4	1	4	4.9	O=C(Cc1cccc(Oc2ccccc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmc.2014.11.018
	118721525	116138	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	507	6	2	6	4.5	CC(C)(C)CC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356407	116138	None	0	Human	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	507	6	2	6	4.5	CC(C)(C)CC(=O)Oc1cccc(CC(=O)N2CCNc3nc(C(F)(F)F)ccc3[C@H]2CC(=O)O)c1	10.1016/j.bmc.2014.11.018
	76314245	105330	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	433	4	1	4	4.8	O=C(Cc1cccc(OC2CCCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115381	105330	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	433	4	1	4	4.8	O=C(Cc1cccc(OC2CCCCC2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	76336004	105346	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2cccc(F)c2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115398	105346	None	0	Mouse	Binding	pEC50	=	8.1	8.1	-	0	Agonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at mouse BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	445	4	1	4	5.0	O=C(Cc1cccc(Oc2cccc(F)c2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	118721524	116137	None	0	Mouse	Binding	pEC50	=	7.1	7.1	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	491	7	2	6	3.8	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(OC(=O)CC2CC2)c1	10.1016/j.bmc.2014.11.018
	CHEMBL3356406	116137	None	0	Mouse	Binding	pEC50	=	7.1	7.1	-	0	Agonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	491	7	2	6	3.8	O=C(O)C[C@@H]1c2ccc(C(F)(F)F)nc2NCCN1C(=O)Cc1cccc(OC(=O)CC2CC2)c1	10.1016/j.bmc.2014.11.018
	155568183	176147	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	420	8	2	4	4.7	CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	CHEMBL4590481	176147	None	0	Human	Binding	pEC50	=	6.1	6.1	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	420	8	2	4	4.7	CC(C)(C)Cc1cnc(CCc2ccc(-c3ccccc3C(=O)O)cc2)n1CC(=O)O	10.1016/j.bmcl.2016.07.056
	76325132	105322	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	442	4	1	5	4.6	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115373	105322	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	442	4	1	5	4.6	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1	10.1016/j.bmcl.2013.12.106
	76325132	105322	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	442	4	1	5	4.6	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1	10.1016/j.bmc.2014.11.018
	CHEMBL3115373	105322	None	0	Human	Binding	pEC50	=	8.0	8.0	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	442	4	1	5	4.6	Cc1ccc(Oc2cccc(CC(=O)N3CCNc4nc(C(F)(F)F)ccc4C3)c2)cn1	10.1016/j.bmc.2014.11.018
	76328694	105319	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	322	3	0	2	4.1	CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C	10.1016/j.bmcl.2013.12.106
	CHEMBL3115370	105319	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	322	3	0	2	4.1	CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C	10.1016/j.bmcl.2013.12.106
	76328694	105319	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	322	3	0	2	4.1	CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C	10.1016/j.bmc.2014.11.018
	CHEMBL3115370	105319	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	322	3	0	2	4.1	CC(=O)N1Cc2ccccc2N(Cc2ccccc2)CC1C(C)C	10.1016/j.bmc.2014.11.018
	155543793	173318	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	434	8	1	5	4.8	COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4522974	173318	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	434	8	1	5	4.8	COC(=O)c1ccccc1-c1ccc(CCc2ncc(CC(C)(C)C)n2CC(=O)O)cc1	10.1016/j.bmcl.2016.07.056
	56840673	1141	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2013.12.106
	8503	1141	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2013.12.106
	CHEMBL2164575	1141	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2013.12.106
	56840673	1141	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmc.2014.11.018
	8503	1141	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmc.2014.11.018
	CHEMBL2164575	1141	None	0	Human	Binding	pEC50	=	7.0	7.0	-	0	Agonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assayAgonist activity at human BRS3 expressed in CHO-K1 cells by IP-One HTRF assay	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1016/j.bmc.2014.11.018
	76332371	105321	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2ccncc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	CHEMBL3115372	105321	None	0	Human	Binding	pEC50	=	6.0	6.0	-	0	Agonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assayAgonist activity at human BRS-3 expressed in CHOK1 cells after 1 hr by HTRF assay	ChEMBL	428	4	1	5	4.3	O=C(Cc1cccc(Oc2ccncc2)c1)N1CCNc2nc(C(F)(F)F)ccc2C1	10.1016/j.bmcl.2013.12.106
	155519753	170545	None	0	Mouse	Binding	pEC50	=	5	5.0	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	342	6	1	3	4.2	COC(=O)C(C)(C)c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	CHEMBL4448645	170545	None	0	Mouse	Binding	pEC50	=	5	5.0	-	0	Agonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assayAgonist activity at mouse BRS3 expressed in CHOK1 cells measured after 1 hrs by IP-One HTRF assay	ChEMBL	342	6	1	3	4.2	COC(=O)C(C)(C)c1ccc(CCc2ncc(CC(C)(C)C)[nH]2)cc1	10.1016/j.bmcl.2016.07.056
	25129212	74218	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	574	5	2	6	5.2	CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1016/j.bmc.2012.03.029
	CHEMBL2023112	74218	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	574	5	2	6	5.2	CC(C)(C(N)=O)c1cccc2c1N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1016/j.bmc.2012.03.029
	59618746	74219	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	586	5	2	6	5.4	NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	CHEMBL2023113	74219	None	0	Human	Binding	pIC50	=	9.3	9.3	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	586	5	2	6	5.4	NC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	25128867	74217	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	669	6	2	9	6.5	CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1	10.1016/j.bmc.2012.03.029
	CHEMBL2023111	74217	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	669	6	2	9	6.5	CC(C)(O)c1nc(C2(c3cccc4c3N(S(=O)(=O)c3ccc(OC(F)(F)F)cc3)Cc3ccc(C(F)(F)F)nc3N4)CCC2)no1	10.1016/j.bmc.2012.03.029
	59618681	82820	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	512	2	1	5	6.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1	10.1021/ml200207w
	CHEMBL2179918	82820	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	512	2	1	5	6.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc4ncccc4c32)cc1	10.1021/ml200207w
	59618753	81907	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	559	4	2	8	5.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1	10.1021/ml200304j
	CHEMBL2164581	81907	None	0	Human	Binding	pIC50	=	9.2	9.2	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	559	4	2	8	5.4	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(CO)n4)c32)cc1	10.1021/ml200304j
	62707362	81903	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	541	3	1	6	6.3	Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1	10.1021/ml200304j
	CHEMBL2164577	81903	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	541	3	1	6	6.3	Cn1cc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)cn1	10.1021/ml200304j
	66901749	82813	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	475	2	1	4	6.2	Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179911	82813	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	475	2	1	4	6.2	Cc1cccc2c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	59618790	81819	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	587	4	2	8	6.1	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	CHEMBL2164223	81819	None	0	Human	Binding	pIC50	=	9.1	9.1	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	587	4	2	8	6.1	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	62707364	81906	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	529	3	1	7	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1	10.1021/ml200304j
	CHEMBL2164580	81906	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	529	3	1	7	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4ncon4)c32)cc1	10.1021/ml200304j
	CHEMBL413893	215559	None	0	Human	Binding	pIC50	=	9.0	9.0	-	0	Inhibition of bombesin subtype 3 receptor expressed in human lung carcinoidsInhibition of bombesin subtype 3 receptor expressed in human lung carcinoids	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O	10.1021/jm049437y
	59618709	82809	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	455	2	1	4	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2	10.1021/ml200207w
	CHEMBL2179908	82809	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	455	2	1	4	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(Cl)nc1N2	10.1021/ml200207w
	62707365	81908	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	573	4	2	8	6.0	C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164582	81908	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	573	4	2	8	6.0	C[C@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	49871766	2557	None	36	Rat	Binding	pIC50	=	8.9	8.9	2	3	Displacement of [3H]Bag-3 from rat BRS-3Displacement of [3H]Bag-3 from rat BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Rat	Binding	pIC50	=	8.9	8.9	2	3	Displacement of [3H]Bag-3 from rat BRS-3Displacement of [3H]Bag-3 from rat BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Rat	Binding	pIC50	=	8.9	8.9	2	3	Displacement of [3H]Bag-3 from rat BRS-3Displacement of [3H]Bag-3 from rat BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	59618821	74216	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	657	6	2	9	6.4	CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1016/j.bmc.2012.03.029
	CHEMBL2023110	74216	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	657	6	2	9	6.4	CC(C)(O)c1nc(C(C)(C)c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1016/j.bmc.2012.03.029
	56840673	1141	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	8503	1141	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	CHEMBL2164575	1141	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	62707363	81904	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	544	3	2	5	6.3	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1	10.1021/ml200304j
	CHEMBL2164578	81904	None	0	Human	Binding	pIC50	=	8.9	8.9	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	544	3	2	5	6.3	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(C4CCNCC4)c32)cc1	10.1021/ml200304j
	25128865	82690	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	475	3	1	4	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179473	82690	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	475	3	1	4	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	25134007	81820	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	573	5	2	8	6.0	CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	CHEMBL2164224	81820	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	573	5	2	8	6.0	CC(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(C(C)(C)O)n4)c32)cc1	10.1021/ml200304j
	59618747	81902	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	538	3	1	5	6.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1	10.1021/ml200304j
	CHEMBL2164576	81902	None	0	Human	Binding	pIC50	=	8.8	8.8	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	538	3	1	5	6.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4cccnc4)c32)cc1	10.1021/ml200304j
	62707528	81818	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	573	4	2	8	6.0	C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164222	81818	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	573	4	2	8	6.0	C[C@@H](O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(C)(C)C)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	46889210	7534	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	387	6	2	2	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087443	7534	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	387	6	2	2	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CNC(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	59618785	82697	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179480	82697	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)s1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	59618635	82700	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	435	2	1	4	5.8	Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2	10.1021/ml200207w
	CHEMBL2179484	82700	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	435	2	1	4	5.8	Cc1ccc2c(n1)Nc1ccc(C)c(C)c1N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)C2	10.1021/ml200207w
	46884660	6444	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1082471	6444	None	0	Human	Binding	pIC50	=	8	8.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnsc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	53242205	60847	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762247	60847	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46884578	8182	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091984	8182	None	0	Human	Binding	pIC50	=	7	7.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccncc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889148	7687	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	406	10	2	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCC(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088686	7687	None	0	Human	Binding	pIC50	=	7.0	7.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	406	10	2	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCC(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	46845425	1032	None	2	Human	Binding	pIC50	=	8.0	8.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	8504	1032	None	2	Human	Binding	pIC50	=	8.0	8.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	CHEMBL1089721	1032	None	2	Human	Binding	pIC50	=	8.0	8.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.03.028
	25026044	57859	None	1	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	390	6	2	4	3.9	CC(O)(Cc1nc(CC2(C(F)(F)F)CC2)c[nH]1)c1ccc(-n2cccn2)cc1	10.1021/ml100196d
	CHEMBL1671874	57859	None	1	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	390	6	2	4	3.9	CC(O)(Cc1nc(CC2(C(F)(F)F)CC2)c[nH]1)c1ccc(-n2cccn2)cc1	10.1021/ml100196d
	46845425	1032	None	2	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	8504	1032	None	2	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1089721	1032	None	2	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	376	8	2	2	5.5	CCC(Cc1c[nH]c(n1)CCc1ccc(cc1)c1ccccc1C(=O)O)(C)C	10.1016/j.bmcl.2010.02.076
	46884630	8422	None	0	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093459	8422	None	0	Human	Binding	pIC50	=	8.0	8.0	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	339	7	1	3	5.3	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccns3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889177	7486	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	497	10	2	4	6.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087066	7486	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	497	10	2	4	6.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(C(F)(F)F)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	59618658	82698	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179481	82698	None	0	Human	Binding	pIC50	=	7.9	7.9	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	507	2	1	5	6.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1csc(C(F)(F)F)c1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46884629	8381	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093183	8381	None	0	Human	Binding	pIC50	=	6.9	6.9	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	358	7	1	3	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C#N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889145	9078	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	398	7	2	4	4.8	c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1	10.1016/j.bmcl.2010.03.028
	CHEMBL1099034	9078	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	398	7	2	4	4.8	c1ccc(-c2nnn[nH]2)c(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)c1	10.1016/j.bmcl.2010.03.028
	25025861	8382	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	CHEMBL1093184	8382	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	56840673	1141	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	8503	1141	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	CHEMBL2164575	1141	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	489	2	1	4	6.5	Cc1c(C)ccc2c1N(Cc1c(N2)nc(cc1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(C)(C)C	10.1021/ml200207w
	25026445	57962	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	367	5	2	3	4.7	CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	CHEMBL1672352	57962	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	367	5	2	3	4.7	CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	46884576	8113	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091598	8113	None	0	Human	Binding	pIC50	=	6.8	6.8	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	331	6	1	2	5.0	c1ccc(-c2ccc(CCc3nc(CC4CCCC4)c[nH]3)cc2)nc1	10.1016/j.bmcl.2010.02.076
	25026058	7671	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	377	7	2	3	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088553	7671	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	377	7	2	3	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCc4cn[nH]c43)cc2)n1	10.1016/j.bmcl.2010.03.028
	62707207	81822	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	597	6	2	9	5.4	CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164226	81822	None	0	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	597	6	2	9	5.4	CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	25025860	569	None	23	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	6188	569	None	23	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1091720	569	None	23	Human	Binding	pIC50	=	7.8	7.8	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	25025861	8382	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093184	8382	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	351	7	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccc(F)cn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618711	74220	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	600	5	2	6	5.6	CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	CHEMBL2023114	74220	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	600	5	2	6	5.6	CNC(=O)C1(c2cccc3c2N(S(=O)(=O)c2ccc(OC(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)CCC1	10.1016/j.bmc.2012.03.029
	71451991	82818	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	477	2	2	5	5.6	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1	10.1021/ml200207w
	CHEMBL2179916	82818	None	0	Human	Binding	pIC50	=	8.7	8.7	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	477	2	2	5	5.6	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(O)c32)cc1	10.1021/ml200207w
	25025860	569	None	23	Rat	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from rat BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from rat BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	6188	569	None	23	Rat	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from rat BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from rat BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1091720	569	None	23	Rat	Binding	pIC50	=	8.6	8.6	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from rat BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from rat BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	46889232	7515	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	401	6	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087200	7515	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	401	6	1	2	5.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc3c(c2)CN(C)C(=O)c2ccccc2-3)n1	10.1016/j.bmcl.2010.03.028
	59618675	82696	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	497	1	1	5	4.8	Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179479	82696	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	497	1	1	5	4.8	Cc1ccc2c(c1C)N(S(=O)(=O)C1=NC(C(C)(C)C)C=[S+]1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46884687	8174	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091917	8174	None	0	Human	Binding	pIC50	=	6.7	6.7	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	324	7	1	5	3.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ncnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889175	7443	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	429	10	2	4	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086673	7443	None	0	Human	Binding	pIC50	=	7.7	7.7	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	429	10	2	4	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	54581470	60848	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762248	60848	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54583453	60869	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	389	5	3	5	3.5	CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762271	60869	None	0	Human	Binding	pIC50	=	6.6	6.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	389	5	3	5	3.5	CC(C)(C)c1cc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)[nH]n1	10.1016/j.bmcl.2011.02.011
	54582477	60868	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	406	5	2	6	4.2	CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762270	60868	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	406	5	2	6	4.2	CC(C)(C)c1csc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	46889235	7661	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	406	8	2	4	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088411	7661	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	406	8	2	4	5.0	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3ncn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46889176	7444	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	444	10	3	5	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086674	7444	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	444	10	3	5	5.1	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(N)n[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	49871766	2557	None	36	Human	Binding	pIC50	=	7.6	7.6	-9	3	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Human	Binding	pIC50	=	7.6	7.6	-9	3	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Human	Binding	pIC50	=	7.6	7.6	-9	3	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	46884688	8175	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091918	8175	None	0	Human	Binding	pIC50	=	7.6	7.6	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	339	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCCC3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46885313	8104	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091554	8104	None	0	Human	Binding	pIC50	=	5.6	5.6	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C(=O)O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46889147	7686	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	445	7	1	5	5.7	O=C1NC(=O)C(c2ccccc2-c2ccc(CCC3N=CC(CC4CCCC4)=N3)cc2)S1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088685	7686	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	445	7	1	5	5.7	O=C1NC(=O)C(c2ccccc2-c2ccc(CCC3N=CC(CC4CCCC4)=N3)cc2)S1	10.1016/j.bmcl.2010.03.028
	136118727	81905	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	545	3	2	7	5.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1	10.1021/ml200304j
	CHEMBL2164579	81905	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	545	3	2	7	5.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(-c4noc(=O)[nH]4)c32)cc1	10.1021/ml200304j
	54583454	60871	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762273	60871	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	66901760	82814	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	495	2	1	4	6.5	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1	10.1021/ml200207w
	CHEMBL2179912	82814	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	495	2	1	4	6.5	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3cccc(Cl)c32)cc1	10.1021/ml200207w
	59618698	82693	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	517	3	1	5	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179476	82693	None	0	Human	Binding	pIC50	=	8.5	8.5	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	517	3	1	5	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(OC(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46200989	2562	None	14	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	8502	2562	None	14	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	CHEMBL2023109	2562	None	14	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of 125I-dY-peptide from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1016/j.bmc.2012.03.029
	46200989	2562	None	14	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1021/ml200304j
	8502	2562	None	14	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1021/ml200304j
	CHEMBL2023109	2562	None	14	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	615	5	2	9	5.7	FC(Oc1ccc(cc1)S(=O)(=O)N1Cc2ccc(nc2Nc2c1c(ccc2)c1noc(n1)C(O)(C)C)C(F)(F)F)(F)F	10.1021/ml200304j
	54580463	60855	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762255	60855	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	54580465	60857	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	390	5	3	5	3.2	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762258	60857	None	0	Human	Binding	pIC50	=	5.5	5.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	390	5	3	5	3.2	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC(C)(C)c1ccccc1	10.1016/j.bmcl.2011.02.011
	136086809	7445	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	445	10	3	4	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=O)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086684	7445	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	445	10	3	4	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=O)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46889146	7685	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	348	7	2	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088684	7685	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	348	7	2	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3O)cc2)n1	10.1016/j.bmcl.2010.03.028
	54581471	60852	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	444	5	3	5	3.6	O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762252	60852	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	444	5	3	5	3.6	O=C(NC12CC3CC(CC(C3)C1)C2)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54582478	60872	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762274	60872	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	25025862	7823	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089521	7823	None	0	Human	Binding	pIC50	=	7.5	7.5	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	322	7	1	3	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884662	7824	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089522	7824	None	0	Human	Binding	pIC50	=	6.5	6.5	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3cncn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46885311	8317	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092730	8317	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	424	7	2	2	6.0	O=C(O)c1cc(F)c(F)cc1-c1ccc(CCc2nc(CC3CCCCC3)c[nH]2)cc1	10.1016/j.bmcl.2010.02.076
	46882011	5893	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	CHEMBL1079517	5893	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin from human BRS3 expressed in NFAT-CHO cells after 2 hrs by liquid scintillation counting	ChEMBL	406	11	3	3	5.2	CCCCc1cnc(C(CCCO)Cc2ccc(-c3ccccc3C(=O)O)cc2)[nH]1	10.1016/j.bmcl.2010.01.154
	11389266	161899	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Inhibition of bombesin subtype 3 receptor expressed in human lung carcinoidsInhibition of bombesin subtype 3 receptor expressed in human lung carcinoids	ChEMBL	1303	44	17	18	-2.7	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O	10.1021/jm049437y
	CHEMBL414307	161899	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Inhibition of bombesin subtype 3 receptor expressed in human lung carcinoidsInhibition of bombesin subtype 3 receptor expressed in human lung carcinoids	ChEMBL	1303	44	17	18	-2.7	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)COCC(=O)Nc1ccc(CC(CNCCN)CNCCN)cc1)C(C)C)C(N)=O	10.1021/jm049437y
	54583450	60858	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	388	4	3	5	3.0	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21	10.1016/j.bmcl.2011.02.011
	CHEMBL1762259	60858	None	0	Human	Binding	pIC50	=	5.4	5.4	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	388	4	3	5	3.0	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCc2ccccc21	10.1016/j.bmcl.2011.02.011
	46884663	7825	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089523	7825	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	323	7	1	4	3.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-n3ccnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618678	82808	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	446	2	1	5	5.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2	10.1021/ml200207w
	CHEMBL2179907	82808	None	0	Human	Binding	pIC50	=	8.4	8.4	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	446	2	1	5	5.3	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C#N)nc1N2	10.1021/ml200207w
	59618646	82699	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	421	2	1	4	5.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2	10.1021/ml200207w
	CHEMBL2179482	82699	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	421	2	1	4	5.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cccnc1N2	10.1021/ml200207w
	54587369	60853	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	354	4	3	5	2.6	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762253	60853	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	354	4	3	5	2.6	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CCCCC1	10.1016/j.bmcl.2011.02.011
	71462686	82810	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	455	2	1	4	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(Cl)cnc1N2	10.1021/ml200207w
	CHEMBL2179909	82810	None	0	Human	Binding	pIC50	=	6.4	6.4	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	455	2	1	4	6.1	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(Cl)cnc1N2	10.1021/ml200207w
	46884659	7819	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089511	7819	None	0	Human	Binding	pIC50	=	7.4	7.4	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	340	7	1	4	4.7	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3csnn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	25026446	57963	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	338	5	2	4	3.6	CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-n3cccn3)cc2)n1	10.1021/ml100196d
	CHEMBL1672353	57963	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	338	5	2	4	3.6	CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(-n3cccn3)cc2)n1	10.1021/ml100196d
	71451990	82817	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	537	3	2	5	6.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1	10.1021/ml200207w
	CHEMBL2179915	82817	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	537	3	2	5	6.2	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccc(C(C)(C)O)c(F)c32)cc1	10.1021/ml200207w
	46889233	7659	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	383	8	2	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088409	7659	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	383	8	2	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.03.028
	25025863	8501	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	430	10	2	5	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1094054	8501	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	430	10	2	5	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	59618620	82819	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	476	2	1	5	5.6	Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179917	82819	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	476	2	1	5	5.6	Cc1ccc2c(n1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	49871766	2557	None	36	Mouse	Binding	pIC50	=	8.3	8.3	-2	3	Displacement of [3H]Bag-3 from mouse BRS-3Displacement of [3H]Bag-3 from mouse BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Mouse	Binding	pIC50	=	8.3	8.3	-2	3	Displacement of [3H]Bag-3 from mouse BRS-3Displacement of [3H]Bag-3 from mouse BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Mouse	Binding	pIC50	=	8.3	8.3	-2	3	Displacement of [3H]Bag-3 from mouse BRS-3Displacement of [3H]Bag-3 from mouse BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	59618811	82816	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	461	2	1	4	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1021/ml200207w
	CHEMBL2179914	82816	None	0	Human	Binding	pIC50	=	8.3	8.3	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	461	2	1	4	5.9	CC(C)(C)c1ccc(S(=O)(=O)N2Cc3ccc(C(F)(F)F)nc3Nc3ccccc32)cc1	10.1021/ml200207w
	71460937	82694	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	493	3	1	4	6.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179477	82694	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	493	3	1	4	6.4	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	59618730	82695	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	500	3	1	5	6.0	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179478	82695	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	500	3	1	5	6.0	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C#N)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	71460964	82815	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	475	2	1	4	6.2	Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179913	82815	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	475	2	1	4	6.2	Cc1ccc2c(c1)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	46884661	7820	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1089512	7820	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	334	7	1	3	4.6	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cnccn3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884627	8379	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1093170	8379	None	0	Human	Binding	pIC50	=	7.3	7.3	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	349	7	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(O)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	1214469	60845	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762245	60845	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54583452	60867	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	399	5	2	4	4.8	CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762269	60867	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	399	5	2	4	4.8	CC(C)(C)c1cccc(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)c1	10.1016/j.bmcl.2011.02.011
	54580462	60851	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	422	6	3	5	3.9	CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762251	60851	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	422	6	3	5	3.9	CC(C)(C)CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46885312	8103	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091553	8103	None	0	Human	Binding	pIC50	=	6.3	6.3	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	377	8	2	3	4.9	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3C(=O)O)cc2)n1	10.1016/j.bmcl.2010.02.076
	46861857	7442	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	461	10	3	4	6.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1086672	7442	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	461	10	3	4	6.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3nc(=S)[nH][nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	46889234	7660	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	407	8	2	5	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1088410	7660	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	407	8	2	5	4.4	CCC(C)(C)Cc1c[nH]c(CCc2ccc(N3CCCC[C@@H]3c3nnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	25026056	8183	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091985	8183	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	347	7	1	2	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(C)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618623	82691	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	501	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179474	82691	None	0	Human	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	501	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(F)(F)F)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	25025860	569	None	23	Mouse	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from mouse BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from mouse BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	6188	569	None	23	Mouse	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from mouse BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from mouse BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	CHEMBL1091720	569	None	23	Mouse	Binding	pIC50	=	8.2	8.2	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from mouse BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from mouse BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(Cc1cnc([nH]1)CCc1ccc(cc1)c1ccccn1)(C)C	10.1016/j.bmcl.2010.02.076
	4157547	25237	None	9	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-[D-Tyr6, b-Ala11, Phe13, Nle14]-Bombesin (6-14) from human BRS3 by competitive binding assayDisplacement of [125I]-[D-Tyr6, b-Ala11, Phe13, Nle14]-Bombesin (6-14) from human BRS3 by competitive binding assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1348293	25237	None	9	Human	Binding	pIC50	=	6.2	6.2	-	0	Displacement of [125I]-[D-Tyr6, b-Ala11, Phe13, Nle14]-Bombesin (6-14) from human BRS3 by competitive binding assayDisplacement of [125I]-[D-Tyr6, b-Ala11, Phe13, Nle14]-Bombesin (6-14) from human BRS3 by competitive binding assay	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	54581472	60861	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	365	4	3	4	3.1	CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762263	60861	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	365	4	3	4	3.1	CC(C)(C)NC(=O)NS(=O)(=O)c1ccccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54584418	60849	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762249	60849	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	54585380	60864	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	380	4	2	5	2.8	CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762266	60864	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	380	4	2	5	2.8	CN(C(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2)C(C)(C)C	10.1016/j.bmcl.2011.02.011
	54586335	60854	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	CHEMBL1762254	60854	None	0	Human	Binding	pIC50	=	6.2	6.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	408	4	3	5	3.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@]1(C)C2(C)C	10.1016/j.bmcl.2011.02.011
	54583451	60866	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	380	4	2	5	2.8	CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762268	60866	None	0	Human	Binding	pIC50	=	5.2	5.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	380	4	2	5	2.8	CN(C(=O)NC(C)(C)C)S(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	53242205	60847	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762247	60847	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	366	4	3	5	2.5	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54582478	60872	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762274	60872	None	0	Human	Binding	pIC50	=	7.2	7.2	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	388	6	3	6	2.9	O=S(=O)(Nc1nc(C2CCC2)n[nH]1)c1cnccc1NC1CC2CCC1C2	10.1016/j.bmcl.2011.02.011
	46884628	8255	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1092381	8255	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	348	7	2	3	4.8	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccc(N)n3)cc2)n1	10.1016/j.bmcl.2010.02.076
	46884577	8114	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	CHEMBL1091599	8114	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation countingDisplacement of [125I]D-Tyr6-betaAla11-Phe13-Nle14-bombesin from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by scintillation counting	ChEMBL	333	7	1	2	5.2	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3cccnc3)cc2)n1	10.1016/j.bmcl.2010.02.076
	59618778	82692	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	511	3	1	6	4.6	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	CHEMBL2179475	82692	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	511	3	1	6	4.6	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(S(C)(=O)=O)cc1)Cc1ccc(C(F)(F)F)nc1N2	10.1021/ml200207w
	54580461	60850	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	380	6	3	5	2.9	CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762250	60850	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	380	6	3	5	2.9	CCC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54581474	60870	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	376	6	3	6	2.7	CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	CHEMBL1762272	60870	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	376	6	3	6	2.7	CC(C)c1n[nH]c(NS(=O)(=O)c2cnccc2N[C@@H]2C[C@H]3CC[C@@H]2C3)n1	10.1016/j.bmcl.2011.02.011
	25134006	81821	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	599	4	2	8	5.8	CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	CHEMBL2164225	81821	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation countingDisplacement of [125I]-dY-peptide from human BRS-3 expressed in NFAT-CHO cells after 2 hrs by by liquid scintillation counting	ChEMBL	599	4	2	8	5.8	CC(C)(O)c1nc(-c2cccc3c2N(S(=O)(=O)c2ccc(C(F)(F)F)cc2)Cc2ccc(C(F)(F)F)nc2N3)no1	10.1021/ml200304j
	59618710	82812	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	473	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2	10.1021/ml200207w
	CHEMBL2179910	82812	None	0	Human	Binding	pIC50	=	8.1	8.1	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation countingDisplacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin(6-14) from human BRS3 expressed in CHO cells expressing NFAT after 2 hrs by liquid scintillation counting	ChEMBL	473	2	1	4	6.2	Cc1ccc2c(c1C)N(S(=O)(=O)c1ccc(C(C)(C)C)cc1)Cc1cc(F)c(Cl)nc1N2	10.1021/ml200207w
	25055504	57961	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	367	5	2	3	4.7	CC(C)(C)Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	CHEMBL1672351	57961	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	367	5	2	3	4.7	CC(C)(C)Cc1c[nH]c(C(C)(O)Cc2ccc(-c3ccc(F)cn3)cc2)n1	10.1021/ml100196d
	11891917	60846	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762246	60846	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	352	5	3	5	2.1	CC(C)NC(=O)NS(=O)(=O)c1cnccc1N[C@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	46889209	7533	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	429	10	2	4	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3cnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	CHEMBL1087442	7533	None	0	Human	Binding	pIC50	=	7.1	7.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	429	10	2	4	5.5	CCC(C)(C)Cc1c[nH]c(CCc2ccc(-c3ccccc3OCc3cnn[nH]3)cc2)n1	10.1016/j.bmcl.2010.03.028
	54586337	60860	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762262	60860	None	0	Human	Binding	pIC50	=	6.1	6.1	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@@H]2CC[C@H]1C2	10.1016/j.bmcl.2011.02.011
	54581473	60865	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	365	4	4	5	2.3	CC(C)(C)NC(=N)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762267	60865	None	0	Human	Binding	pIC50	=	5.0	5.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	365	4	4	5	2.3	CC(C)(C)NC(=N)NS(=O)(=O)c1cnccc1N[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	54585379	60859	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL1762261	60859	None	0	Human	Binding	pIC50	=	6	6.0	-	0	Binding affinity to human BRS3Binding affinity to human BRS3	ChEMBL	367	4	2	5	2.4	CC(C)(C)NC(=O)NS(=O)(=O)c1cnccc1O[C@@H]1C[C@H]2CC[C@@H]1C2	10.1016/j.bmcl.2011.02.011
	CHEMBL525577	218143	None	0	Human	Binding	pKi	=	9.4	9.4	2	3	Binding affinity to BRS-3 receptorBinding affinity to BRS-3 receptor	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](N)Cc1ccccc1)C(C)C)C(N)=O	10.1016/j.bmcl.2008.09.033
	49871766	2557	None	36	Rat	Binding	pKi	=	9.2	9.2	2	3	Displacement of [3H]Bag-3 from rat BRS-3Displacement of [3H]Bag-3 from rat BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Rat	Binding	pKi	=	9.2	9.2	2	3	Displacement of [3H]Bag-3 from rat BRS-3Displacement of [3H]Bag-3 from rat BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Rat	Binding	pKi	=	9.2	9.2	2	3	Displacement of [3H]Bag-3 from rat BRS-3Displacement of [3H]Bag-3 from rat BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	49871766	2557	None	36	Mouse	Binding	pKi	=	8.8	8.8	-2	3	Displacement of [3H]Bag-3 from mouse BRS-3Displacement of [3H]Bag-3 from mouse BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Mouse	Binding	pKi	=	8.8	8.8	-2	3	Displacement of [3H]Bag-3 from mouse BRS-3Displacement of [3H]Bag-3 from mouse BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Mouse	Binding	pKi	=	8.8	8.8	-2	3	Displacement of [3H]Bag-3 from mouse BRS-3Displacement of [3H]Bag-3 from mouse BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	49871766	2557	None	36	Human	Binding	pKi	=	8.4	8.4	-9	3	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	6170	2557	None	36	Human	Binding	pKi	=	8.4	8.4	-9	3	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	CHEMBL1672354	2557	None	36	Human	Binding	pKi	=	8.4	8.4	-9	3	Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3Displacement of [125I]-[D-Tyr6,beta-Ala11,Phe13,Nle14]-Bombesin (6-14) from human BRS-3	ChEMBL	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	10.1021/ml100196d
	71300326	118565	None	32	Human	Binding	pKi	=	5.1	5.1	-6	3	Selectivity interaction (Enzyme panel (ion channels, GPCRs, other targets)) EUB0000196bCl BRS3Selectivity interaction (Enzyme panel (ion channels, GPCRs, other targets)) EUB0000196bCl BRS3	ChEMBL	499	6	2	4	3.0	O=C([C@@H](Cc1cccc(C(F)(F)F)c1)NS(=O)(=O)c1cc(F)c2c(c1)CCNC2)N1CCCC1	10.6019/CHEMBL5212743
	CHEMBL3414622	118565	None	32	Human	Binding	pKi	=	5.1	5.1	-6	3	Selectivity interaction (Enzyme panel (ion channels, GPCRs, other targets)) EUB0000196bCl BRS3Selectivity interaction (Enzyme panel (ion channels, GPCRs, other targets)) EUB0000196bCl BRS3	ChEMBL	499	6	2	4	3.0	O=C([C@@H](Cc1cccc(C(F)(F)F)c1)NS(=O)(=O)c1cc(F)c2c(c1)CCNC2)N1CCCC1	10.6019/CHEMBL5212743
	CHEMBL4789678	118565	None	32	Human	Binding	pKi	=	5.1	5.1	-6	3	Selectivity interaction (Enzyme panel (ion channels, GPCRs, other targets)) EUB0000196bCl BRS3Selectivity interaction (Enzyme panel (ion channels, GPCRs, other targets)) EUB0000196bCl BRS3	ChEMBL	499	6	2	4	3.0	O=C([C@@H](Cc1cccc(C(F)(F)F)c1)NS(=O)(=O)c1cc(F)c2c(c1)CCNC2)N1CCCC1	10.6019/CHEMBL5212743
	25025654	570	None	12	Mouse	Binding	pKd	=	8.6	8.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	6189	570	None	12	Mouse	Binding	pKd	=	8.6	8.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	8506	570	None	12	Mouse	Binding	pKd	=	8.6	8.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	CHEMBL1084942	570	None	12	Mouse	Binding	pKd	=	8.6	8.6	-	1	UnclassifiedUnclassified	Guide to Pharmacology	374	7	2	2	5.3	OC(=O)c1ccccc1c1ccc(cc1)CCc1ncc([nH]1)CC1CCCC1	20096642
	164512405	218439	125I-[D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	5355	218439	125I-[D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	5355.0	218439	125I-[D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	CHEMBL26	218439	125I-[D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	DB00391	218439	125I-[D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	None	218575	125I-[D-Tyr6,Beta-Ala11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-	1	NoneNone	PDSP KiDatabase	1054	32	14	14	-3.4	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)N	None
	None	218575	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-	1	NoneNone	PDSP KiDatabase	1054	32	14	14	-3.4	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)N	None
	23185015	218576	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-	1	NoneNone	PDSP KiDatabase	2858	85	36	38	-8.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CNC=N1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CNC=N4)NC(=O)C(CC(=O)N)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C5CCCN5C(=O)C(CC6=CC=C(C=C6)O)NC(=O)C(CCSC)NC(=O)C(CCCCN)NC(=O)C(C(C)O)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C(C(C)O)NC(=O)CNC(=O)CNC(=O)CNC(=O)C(C)NC(=O)C7CCCN7C(=O)C(CC(C)C)NC(=O)C8CCCN8C(=O)C(C(C)C)N	None
	None	218581	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5	5.0	-	1	NoneNone	PDSP KiDatabase	1120	33	15	15	-3.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)C(CC1=CN=CN1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CC4=CN=CN4)NC(=O)C(CC(=O)N)NC(=O)CN	None
	None	218579	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.7	5.7	-	1	NoneNone	PDSP KiDatabase	1019	28	12	12	-1.3	CC(C)CC(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NCC(=O)NC(CO)C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CCSC)C(=O)N)NC(=O)C4CCC(=O)N4	None
	None	218580	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.5	5.5	-	1	NoneNone	PDSP KiDatabase	1071	29	13	13	-1.6	CCC(C)C(C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(C)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CC3=CN=CN3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCSC)C(=O)N)NC(=O)C5CCC(=O)N5	None
	25078137	218578	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.4	5.4	-	1	NoneNone	PDSP KiDatabase	1535	47	21	20	-6.1	C[C@H]([C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC3=CN=CN3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@@H]4CCC(=O)N4)O	None
	None	218577	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.4	5.4	-	1	NoneNone	PDSP KiDatabase	1084	30	13	13	-2.1	CC(C)C(C(=O)NCC(=O)NC(CC1=CN=CN1)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCSC)C(=O)N)NC(=O)C(C)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CCC(=O)N)NC(=O)C5CCC(=O)N5	None
	164512405	218439	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.3	5.3	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	5355	218439	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.3	5.3	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	5355.0	218439	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.3	5.3	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	CHEMBL26	218439	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.3	5.3	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	DB00391	218439	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.3	5.3	-316	12	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
	164512399	218583	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.2	5.2	-	1	NoneNone	PDSP KiDatabase	304	7	4	9	-10.5	C(C(C(C(C(=O)COP(=O)([O-])[O-])O)O)O)O.[Na+].[Na+]	None
	22146595	3290	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.2	5.2	-3467	3	NoneNone	PDSP KiDatabase		None	None	None		None	None
	618	3290	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.2	5.2	-3467	3	NoneNone	PDSP KiDatabase		None	None	None		None	None
	None	218582	125I-[DTyr6,BetaAla11,Phe13,Nle14]Bn(6-14)	0	Human	Binding	pKi	=	5.2	5.2	-	1	NoneNone	PDSP KiDatabase		None	None	None		None	None
	49871766	2557	None	36	Human	Binding	pKi	=	8.1	8.1	-9	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	23892571
	49871766	2557	None	36	Human	Binding	pKi	=	8.1	8.1	-9	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	6170	2557	None	36	Human	Binding	pKi	=	8.1	8.1	-9	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	23892571
	6170	2557	None	36	Human	Binding	pKi	=	8.1	8.1	-9	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	CHEMBL1672354	2557	None	36	Human	Binding	pKi	=	8.1	8.1	-9	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	23892571
	CHEMBL1672354	2557	None	36	Human	Binding	pKi	=	8.1	8.1	-9	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	24900253
	3946	1503	None	0	Human	Binding	pKi	=	8.1	8.1	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15102928
	632	1478	None	0	Human	Binding	pKi	=	8.2	8.2	-6	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9325344
	633	1505	None	0	Human	Binding	pKi	=	8.4	8.4	-	1	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11112777
	49871766	2557	None	36	Mouse	Binding	pKi	=	8.8	8.8	-2	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	21036912
	6170	2557	None	36	Mouse	Binding	pKi	=	8.8	8.8	-2	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	21036912
	CHEMBL1672354	2557	None	36	Mouse	Binding	pKi	=	8.8	8.8	-2	3	UnclassifiedUnclassified	Guide to Pharmacology	444	6	2	4	4.5	FC([C@@](c1ccc(cc1)n1cccn1)(Cc1ncc([nH]1)CC1(CC1)C(F)(F)F)O)(F)F	21036912
	632	1478	None	0	Mouse	Binding	pKi	=	8.8	8.8	-1	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10454496
	632	1478	None	0	Rat	Binding	pKi	=	9	9.0	1	5	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10454496

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Ligand source activities (1 row/activity)