Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
49779990 135736 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 4.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCCC1)C21CC1 nan
CHEMBL3730217 135736 0 None - 1 Human 10.2 pEC50 = 10.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 4.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCCC1)C21CC1 nan
67496162 135504 0 None - 1 Human 10.0 pEC50 = 10 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 8 2 3 4.2 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728769 135504 0 None - 1 Human 10.0 pEC50 = 10 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 8 2 3 4.2 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495697 135540 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 5 3 3 3.9 NC[C@H]1CC[C@@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3729012 135540 0 None - 1 Human 9.9 pEC50 = 9.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 5 3 3 3.9 NC[C@H]1CC[C@@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67495547 135304 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 8 3 3 3.5 NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727613 135304 0 None - 1 Human 9.8 pEC50 = 9.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 8 3 3 3.5 NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67496555 135532 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 443 4 3 3 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 nan
CHEMBL3728932 135532 0 None - 1 Human 9.7 pEC50 = 9.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 443 4 3 3 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 nan
67495917 135574 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 5 2 2 4.0 CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729214 135574 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 5 2 2 4.0 CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
124093849 183052 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 330 4 2 3 3.1 COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113194
CHEMBL4794375 183052 0 None - 1 Human 9.6 pEC50 = 9.6 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 330 4 2 3 3.1 COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113194
127024365 135708 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@H]1F)C21CC1 nan
CHEMBL3730056 135708 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@H]1F)C21CC1 nan
67496467 135772 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 7 3 3 3.1 NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730438 135772 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 7 3 3 3.1 NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
127024366 135723 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@@H]1F)C21CC1 nan
CHEMBL3730133 135723 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC[C@@H]1F)C21CC1 nan
67495052 135975 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 8 2 3 4.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731671 135975 0 None - 1 Human 9.5 pEC50 = 9.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 8 2 3 4.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495909 135608 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 8 2 3 3.8 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC1)C21CC1 nan
CHEMBL3729434 135608 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 8 2 3 3.8 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC1)C21CC1 nan
67495424 136139 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 6 2 3 2.9 CN(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732621 136139 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 6 2 3 2.9 CN(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422323 135884 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 8 3 5 3.1 NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3731107 135884 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 8 3 5 3.1 NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
87422349 135914 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 466 5 3 5 3.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCNC1)C21CC1 nan
CHEMBL3731259 135914 0 None - 1 Human 9.4 pEC50 = 9.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 466 5 3 5 3.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCNC1)C21CC1 nan
67496515 135844 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 433 6 3 3 2.4 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3730874 135844 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 433 6 3 3 2.4 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 nan
87422373 135303 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 440 7 3 5 2.8 NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3727601 135303 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 440 7 3 5 2.8 NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
67496242 135487 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 501 8 2 4 3.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCOCC1)C21CC1 nan
CHEMBL3728644 135487 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 501 8 2 4 3.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCOCC1)C21CC1 nan
67495587 135895 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 6 3 3 4.0 NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1 nan
CHEMBL3731166 135895 0 None - 1 Human 9.3 pEC50 = 9.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 6 3 3 4.0 NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1 nan
87422150 135415 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 8 3 5 2.9 NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728245 135415 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 8 3 5 2.9 NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
67495044 135610 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 9 2 3 4.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCCN1CCCC1)C21CC1 nan
CHEMBL3729460 135610 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 9 2 3 4.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCCN1CCCC1)C21CC1 nan
67495611 136043 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 9 2 3 4.3 CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3732081 136043 0 None - 1 Human 9.2 pEC50 = 9.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 9 2 3 4.3 CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 nan
67496319 135726 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 501 9 2 4 3.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCOCCN1CCCC1)C21CC1 nan
CHEMBL3730159 135726 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 501 9 2 4 3.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCOCCN1CCCC1)C21CC1 nan
67495075 135886 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 5 3 3 3.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 nan
CHEMBL3731113 135886 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 5 3 3 3.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 nan
67496410 136184 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.3 O=C(Nc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732902 136184 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.3 O=C(Nc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
71526099 182366 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 385 7 4 3 2.2 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O 10.1016/j.ejmech.2021.113194
CHEMBL4785302 182366 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 385 7 4 3 2.2 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O 10.1016/j.ejmech.2021.113194
67495605 135970 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 528 8 2 4 3.8 CN1CCCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3731635 135970 0 None - 1 Human 9.1 pEC50 = 9.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 528 8 2 4 3.8 CN1CCCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67496025 135541 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 429 4 3 3 2.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNC1)C21CC1 nan
CHEMBL3729013 135541 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 429 4 3 3 2.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNC1)C21CC1 nan
67495735 135578 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 6 3 3 3.3 CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729228 135578 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 6 3 3 3.3 CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
457933 215700 28 None 501 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C 10.1021/jm900592h
CHEMBL552527 215700 28 None 501 2 Human 9.0 pEC50 = 9 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](CCSC)C(N)=O)C(C)C 10.1021/jm900592h
67495663 135582 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 3 4.5 CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729246 135582 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 3 4.5 CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67496799 135942 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 418 6 3 3 2.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCO)C21CC1 nan
CHEMBL3731461 135942 0 None - 1 Human 9.0 pEC50 = 9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 418 6 3 3 2.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCO)C21CC1 nan
71525458 91684 0 None - 1 Human 9.0 pEC50 = 9 Functional
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
ChEMBL 413 7 4 3 3.0 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NC(C)(C)C(=O)O 10.1021/ml400179m
CHEMBL2408793 91684 0 None - 1 Human 9.0 pEC50 = 9 Functional
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
ChEMBL 413 7 4 3 3.0 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NC(C)(C)C(=O)O 10.1021/ml400179m
87422149 135894 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 8 2 4 3.6 O=C(Nc1ccc(Br)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731163 135894 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 8 2 4 3.6 O=C(Nc1ccc(Br)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495489 136005 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 6 3 3 2.2 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731849 136005 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 6 3 3 2.2 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
89685025 135732 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 529 4 2 4 4.3 CC(C)(C)OC(=O)N1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1 nan
CHEMBL3730197 135732 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 529 4 2 4 4.3 CC(C)(C)OC(=O)N1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1 nan
87422150 135415 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 8 3 5 2.9 NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728245 135415 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 8 3 5 2.9 NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
67495157 135618 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 4 2 2 4.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCC1)C21CC1 nan
CHEMBL3729500 135618 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 4 2 2 4.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCC1)C21CC1 nan
127036711 135754 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 9 2 4 3.5 O=C(NCc1ccc(Br)nc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730330 135754 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 9 2 4 3.5 O=C(NCc1ccc(Br)nc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496296 136014 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.3 O=C(Nc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731889 136014 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.3 O=C(Nc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496273 136128 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 7 2 4 3.2 CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3CC[C@H]2C32CC2)CC1 nan
CHEMBL3732566 136128 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 7 2 4 3.2 CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3CC[C@H]2C32CC2)CC1 nan
87422149 135894 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 8 2 4 3.6 O=C(Nc1ccc(Br)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731163 135894 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 8 2 4 3.6 O=C(Nc1ccc(Br)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495854 136096 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 417 6 3 3 2.7 NCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732404 136096 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 417 6 3 3 2.7 NCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495754 136290 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 529 10 2 4 4.2 COCC1CCCN1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728573 136290 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 529 10 2 4 4.2 COCC1CCCN1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3733986 136290 0 None - 1 Human 8.9 pEC50 = 8.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 529 10 2 4 4.2 COCC1CCCN1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495370 135615 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 5 2 3 3.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCO1)C21CC1 nan
CHEMBL3729487 135615 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 5 2 3 3.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCO1)C21CC1 nan
87421981 135272 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 8 2 4 3.5 O=C(Nc1ccc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727408 135272 0 None - 1 Human 8.8 pEC50 = 8.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 8 2 4 3.5 O=C(Nc1ccc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496224 135473 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 420 6 3 3 2.9 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCO)C21CC1 nan
CHEMBL3728559 135473 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 420 6 3 3 2.9 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCO)C21CC1 nan
67495939 136199 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 8 2 3 3.8 CCOCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3733012 136199 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 8 2 3 3.8 CCOCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495657 136288 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 4.6 CC(CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)N1CCCC1 nan
CHEMBL3731167 136288 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 4.6 CC(CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)N1CCCC1 nan
CHEMBL3733984 136288 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 4.6 CC(CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)N1CCCC1 nan
42629962 180691 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 377 6 1 8 3.0 CC(=O)c1coc(Cn2ccc(NC(=O)c3ncoc3-c3ccccc3)n2)n1 10.1016/j.ejmech.2021.113194
CHEMBL4755656 180691 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 377 6 1 8 3.0 CC(=O)c1coc(Cn2ccc(NC(=O)c3ncoc3-c3ccccc3)n2)n1 10.1016/j.ejmech.2021.113194
146597621 191313 0 None 33 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5191583 191313 0 None 33 2 Human 8.0 pEC50 = 8 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1 10.1021/acsmedchemlett.2c00079
67495008 135373 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 464 8 2 5 4.1 O=C(Nc1ccc2scnc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728025 135373 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 464 8 2 5 4.1 O=C(Nc1ccc2scnc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496354 135697 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 403 5 3 3 2.3 NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729988 135697 0 None - 1 Human 8.0 pEC50 = 8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 403 5 3 3 2.3 NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
57378085 153656 0 None - 1 Human 8.0 pEC50 = 8 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 442 6 2 9 3.4 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(Cl)c2)o1 nan
CHEMBL3981311 153656 0 None - 1 Human 8.0 pEC50 = 8 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 442 6 2 9 3.4 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(Cl)c2)o1 nan
57378194 150498 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 408 6 2 9 2.8 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2ccccc2)o1 nan
CHEMBL3954589 150498 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 408 6 2 9 2.8 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2ccccc2)o1 nan
22430370 79751 8 None - 1 Human 7.0 pEC50 = 7 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 390 3 2 4 4.1 Cc1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL211885 79751 8 None - 1 Human 7.0 pEC50 = 7 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 390 3 2 4 4.1 Cc1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
44413564 138746 0 None - 1 Human 7.0 pEC50 = 7 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 396 5 2 4 4.9 CCn1c(C(C)C)c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n1-c1ccccc1 10.1016/j.bmcl.2006.04.068
CHEMBL378064 138746 0 None - 1 Human 7.0 pEC50 = 7 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 396 5 2 4 4.9 CCn1c(C(C)C)c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n1-c1ccccc1 10.1016/j.bmcl.2006.04.068
25238441 19101 8 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 348 5 2 2 3.8 COc1ccc(CCNC(=O)Nc2ccc(Br)cc2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL1289381 19101 8 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 348 5 2 2 3.8 COc1ccc(CCNC(=O)Nc2ccc(Br)cc2)cc1 10.1016/j.bmc.2015.03.062
67495644 135367 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 5 3 3 3.4 NC(=O)C1CCCCC1NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728007 135367 0 None - 1 Human 7.0 pEC50 = 7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 5 3 3 3.4 NC(=O)C1CCCCC1NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
71698362 90674 0 None 3 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 455 6 1 6 3.2 COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391446 90674 0 None 3 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 455 6 1 6 3.2 COc1cccc(C(=O)c2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
122181323 121838 0 None -2 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590074 121838 0 None -2 2 Mouse 6.0 pEC50 = 6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
168273654 190302 0 None 6 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5176452 190302 0 None 6 2 Human 6.0 pEC50 = 6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
708867 121886 13 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 347 5 2 4 4.0 COc1ccc2[nH]c(SCC(=O)Nc3ccccc3Cl)nc2c1 10.1016/j.bmc.2015.03.062
CHEMBL3590214 121886 13 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 347 5 2 4 4.0 COc1ccc2[nH]c(SCC(=O)Nc3ccccc3Cl)nc2c1 10.1016/j.bmc.2015.03.062
87422106 135813 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 498 8 2 5 4.7 O=C(Nc1nc2ccc(Cl)cc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730690 135813 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 498 8 2 5 4.7 O=C(Nc1nc2ccc(Cl)cc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496037 136036 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 9 2 3 4.3 O=C(NCc1ccc(F)c(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732039 136036 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 9 2 3 4.3 O=C(NCc1ccc(F)c(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
24776345 155451 7 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 388 3 1 4 4.3 COc1ccc2[nH]c(C(=O)N3CCC(n4c(C)nc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
CHEMBL404003 155451 7 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 388 3 1 4 4.3 COc1ccc2[nH]c(C(=O)N3CCC(n4c(C)nc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
67496375 136202 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 7 2 2 4.5 CCCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3733047 136202 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 7 2 2 4.5 CCCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495422 136229 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1cc(F)c(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733207 136229 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1cc(F)c(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL5075000 214330 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCNCC2)C1=O 10.1016/j.ejmech.2021.113805
67495590 136279 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 11 2 5 3.1 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(OC)c1 nan
CHEMBL3730542 136279 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 11 2 5 3.1 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(OC)c1 nan
CHEMBL3733974 136279 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 11 2 5 3.1 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(OC)c1 nan
67496493 136286 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 11 2 4 3.9 COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Br nan
CHEMBL3728781 136286 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 11 2 4 3.9 COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Br nan
CHEMBL3733981 136286 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 11 2 4 3.9 COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Br nan
67496529 135514 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 402 8 3 6 1.1 CNCCNC(=O)[C@H]1[C@H](C(=O)NCc2nc(C(C)=O)cs2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728812 135514 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 402 8 3 6 1.1 CNCCNC(=O)[C@H]1[C@H](C(=O)NCc2nc(C(C)=O)cs2)[C@@H]2C=C[C@H]1C21CC1 nan
67495926 135879 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 497 9 2 3 4.5 CC(C)CCN1CCC(NC(=O)[C@H]2[C@H](C(=O)NCCc3ccc(Cl)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3731064 135879 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 497 9 2 3 4.5 CC(C)CCN1CCC(NC(=O)[C@H]2[C@H](C(=O)NCCc3ccc(Cl)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
92263206 174149 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometryAgonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
CHEMBL4547265 174149 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometryAgonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometry
ChEMBL 465 8 3 5 3.5 COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OC(C)(C)C 10.1039/C9MD00336C
67495041 136212 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 9 3 6 3.4 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCc2nc4ccccc4[nH]2)C32CC2)n1 nan
CHEMBL3733092 136212 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 9 3 6 3.4 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCc2nc4ccccc4[nH]2)C32CC2)n1 nan
87422369 135497 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 490 9 2 4 3.8 O=C(NCc1cc(Cl)nc(Cl)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728722 135497 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 490 9 2 4 3.8 O=C(NCc1cc(Cl)nc(Cl)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
44236330 194807 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 194807 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
155524563 170901 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometryAgonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4455225 170901 0 None 1 2 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometryAgonist activity at FRP2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization incubated for 30 mins and measured for 5 sec for 240 sec by fluorometry
ChEMBL 435 9 3 4 3.2 COC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
87422340 135695 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 8 3 6 2.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCOCCO)C21CC1 nan
CHEMBL3729977 135695 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 8 3 6 2.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCOCCO)C21CC1 nan
67495887 135826 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 6 1 3 3.2 CN(C)CCN(C)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730777 135826 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 6 1 3 3.2 CN(C)CCN(C)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67496610 135922 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 531 8 3 4 4.6 CC(C)(C)OC(=O)NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731311 135922 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 531 8 3 4 4.6 CC(C)(C)OC(=O)NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67496373 136293 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 8 2 4 3.9 O=C(Nc1ccc(C(F)(F)F)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730922 136293 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 8 2 4 3.9 O=C(Nc1ccc(C(F)(F)F)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733989 136293 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 8 2 4 3.9 O=C(Nc1ccc(C(F)(F)F)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
57378198 154076 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 408 6 2 9 2.8 Cc1cccc(-c2ocnc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
CHEMBL3984964 154076 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 408 6 2 9 2.8 Cc1cccc(-c2ocnc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
57377975 153083 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 422 6 2 9 3.1 Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
CHEMBL3976318 153083 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 422 6 2 9 3.1 Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
162657722 181118 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 436 4 3 3 4.6 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccc(Cl)nc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4760670 181118 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 436 4 3 3 4.6 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccc(Cl)nc2)CCCC1 10.1016/j.ejmech.2021.113194
145954612 162546 0 None 2 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4168567 162546 0 None 2 2 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
168270850 189875 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 377 3 2 3 3.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3cc(Cl)ccc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5169641 189875 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 377 3 2 3 3.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3cc(Cl)ccc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
162659418 181210 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 433 5 3 4 4.3 CC(C)n1cc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1 10.1016/j.ejmech.2021.113194
CHEMBL4761559 181210 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 433 5 3 4 4.3 CC(C)n1cc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1 10.1016/j.ejmech.2021.113194
122181324 121839 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 542 9 4 3 6.1 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590075 121839 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 542 9 4 3 6.1 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
44233646 196400 0 None -1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 196400 0 None -1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
44233646 196400 0 None -1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 196400 0 None -1 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
168291793 191907 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5200365 191907 0 None 2 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
67496049 135418 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 3 3.7 Cc1ccc(C)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1 nan
CHEMBL3728279 135418 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 3 3.7 Cc1ccc(C)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1 nan
67495233 135777 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 516 6 2 4 4.8 O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1ccnn1-c1ccccc1 nan
CHEMBL3730474 135777 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 516 6 2 4 4.8 O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1ccnn1-c1ccccc1 nan
67495759 136060 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 447 7 3 3 2.1 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3732166 136060 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 447 7 3 3 2.1 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 nan
164916035 192326 3 None 16 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5207056 192326 3 None 16 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
67495025 135946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 3 3 2.6 NC(=O)CCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731489 135946 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 3 3 2.6 NC(=O)CCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
71699060 90667 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391437 90667 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2cccs2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
67495872 135957 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 468 5 2 4 3.7 Cc1cc(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nn1C nan
CHEMBL3731544 135957 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 468 5 2 4 3.7 Cc1cc(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nn1C nan
71698880 90645 0 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 411 5 1 4 3.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391277 90645 0 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 411 5 1 4 3.5 Cc1cc(Cc2ccccc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
67495767 135517 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728830 135517 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496309 135638 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 5 2 3 3.7 CC(NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)N1CCCCC1 nan
CHEMBL3729615 135638 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 5 2 3 3.7 CC(NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)N1CCCCC1 nan
67495874 136119 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 5 2 3 4.3 Cc1ccncc1C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732516 136119 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 5 2 3 4.3 Cc1ccncc1C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
44232924 195300 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 195300 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44232924 195300 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 195300 0 None 1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
67495436 136264 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1c(F)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F nan
CHEMBL3728119 136264 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1c(F)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F nan
CHEMBL3733941 136264 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1c(F)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F nan
127024138 135923 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 549 10 2 3 4.2 O=C(NCCc1cc(F)c(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731316 135923 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 549 10 2 3 4.2 O=C(NCCc1cc(F)c(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
87422013 135639 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 6 3 5 2.8 CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729617 135639 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 6 3 5 2.8 CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
67495280 135847 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 6 2 4 4.2 CN(CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)OC(C)(C)C nan
CHEMBL3730902 135847 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 6 2 4 4.2 CN(CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)OC(C)(C)C nan
67494881 135965 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 6 2 3 3.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCCC1)C21CC1 nan
CHEMBL3731600 135965 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 6 2 3 3.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCCC1)C21CC1 nan
67495727 136115 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 455 6 2 5 2.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCn1cncn1)C21CC1 nan
CHEMBL3732504 136115 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 455 6 2 5 2.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCn1cncn1)C21CC1 nan
57378082 147778 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 438 7 2 10 2.8 COc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
CHEMBL3932747 147778 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 438 7 2 10 2.8 COc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
145949892 162796 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4172556 162796 0 None 2 2 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
87421942 135360 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 459 9 2 7 2.8 O=C(Nc1ncc([N+](=O)[O-])s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727914 135360 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 459 9 2 7 2.8 O=C(Nc1ncc([N+](=O)[O-])s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
44233647 195512 0 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 195512 0 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
44233647 195512 0 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 195512 0 None 1 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
87422045 135694 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 8 2 5 3.6 O=C(Nc1ncc(Cl)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729966 135694 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 8 2 5 3.6 O=C(Nc1ncc(Cl)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496039 136064 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 501 11 2 3 4.1 CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732195 136064 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 501 11 2 3 4.1 CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
24776356 167507 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 442 4 1 4 5.1 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(OC(F)(F)F)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL430016 167507 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 442 4 1 4 5.1 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(OC(F)(F)F)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
67495634 135810 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 533 6 2 3 5.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCN(Cc3ccccc3)CC1)C21CC1 nan
CHEMBL3730675 135810 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 533 6 2 3 5.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCN(Cc3ccccc3)CC1)C21CC1 nan
22430372 140102 11 None - 1 Human 4.9 pEC50 = 4.9 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 364 4 2 4 4.3 Cc1c(NC(=O)Nc2ccc(C(C)C)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL380160 140102 11 None - 1 Human 4.9 pEC50 = 4.9 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 364 4 2 4 4.3 Cc1c(NC(=O)Nc2ccc(C(C)C)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
44232677 196323 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 408 7 1 7 2.7 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1 10.1021/jm900592h
CHEMBL562456 196323 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 408 7 1 7 2.7 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc([N+](=O)[O-])cc3)c2=O)c1 10.1021/jm900592h
162653824 180464 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 447 6 3 4 4.5 CC(C)n1cc(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)cn1 10.1016/j.ejmech.2021.113194
CHEMBL4753061 180464 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 447 6 3 4 4.5 CC(C)n1cc(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)cn1 10.1016/j.ejmech.2021.113194
67496284 135571 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 5 2 2 4.0 CC(C)C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729198 135571 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 5 2 2 4.0 CC(C)C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
909951 172657 15 None - 1 Human 5.9 pEC50 = 5.9 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 336 3 2 4 3.4 Cc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
CHEMBL450023 172657 15 None - 1 Human 5.9 pEC50 = 5.9 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 336 3 2 4 3.4 Cc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
67496639 136267 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 505 10 2 4 4.0 O=C(NCc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729738 136267 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 505 10 2 4 4.0 O=C(NCc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733944 136267 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 505 10 2 4 4.0 O=C(NCc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
122181233 121822 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589947 121822 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
87422138 136033 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 5 3 5 3.7 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1(O)CCCCC1)C21CC1 nan
CHEMBL3732017 136033 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 5 3 5 3.7 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1(O)CCCCC1)C21CC1 nan
67495929 135274 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 7 2 4 4.2 Cc1cc(C)n(CCC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)n1 nan
CHEMBL3727417 135274 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 7 2 4 4.2 Cc1cc(C)n(CCC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)n1 nan
67495288 135299 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 440 5 2 3 4.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCc1ccoc1)C21CC1 nan
CHEMBL3727544 135299 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 440 5 2 3 4.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCc1ccoc1)C21CC1 nan
67495409 135552 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729082 135552 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495697 135825 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 5 3 3 3.9 NC[C@H]1CC[C@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3730760 135825 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 5 3 3 3.9 NC[C@H]1CC[C@H](NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67496347 135850 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 519 9 2 3 4.2 O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730919 135850 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 519 9 2 3 4.2 O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
87421983 136230 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 426 6 3 5 2.2 CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3733217 136230 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 426 6 3 5 2.2 CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
57378197 153720 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 426 6 2 9 2.9 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(F)c2)o1 nan
CHEMBL3981821 153720 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 426 6 2 9 2.9 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(F)c2)o1 nan
98363171 121704 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 540 7 3 4 4.5 CCOC(=O)C1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(Br)cc2)CC1 10.1016/j.bmc.2015.03.062
CHEMBL3588923 121704 1 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 540 7 3 4 4.5 CCOC(=O)C1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(Br)cc2)CC1 10.1016/j.bmc.2015.03.062
CHEMBL5087410 215073 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1 10.1016/j.ejmech.2021.113805
24776350 94026 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 388 4 1 4 4.2 CCc1nc2ccccc2n1C1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL248928 94026 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 388 4 1 4 4.2 CCc1nc2ccccc2n1C1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
162645753 179488 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 444 6 3 3 4.9 O=C(Nc1ccc(Br)cc1)NC(CC1CCCCC1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
CHEMBL4741207 179488 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 444 6 3 3 4.9 O=C(Nc1ccc(Br)cc1)NC(CC1CCCCC1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
145951856 162867 0 None 8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4173645 162867 0 None 8 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
168282661 190966 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 358 4 3 4 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc3ccccc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5186339 190966 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 358 4 3 4 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc3ccccc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
168269851 189942 0 None 3 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5170711 189942 0 None 3 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
67495955 135503 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 6 2 3 4.1 CCN1CCC(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3728768 135503 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 6 2 3 4.1 CCN1CCC(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67496243 136272 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 422 8 2 4 3.1 Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1 nan
CHEMBL3727715 136272 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 422 8 2 4 3.1 Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1 nan
CHEMBL3733949 136272 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 422 8 2 4 3.1 Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1 nan
44233905 196310 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
CHEMBL562380 196310 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
44233905 196310 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
CHEMBL562380 196310 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
67495244 135641 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 458 8 1 2 5.3 CCCCCCN(C)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729626 135641 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 458 8 1 2 5.3 CCCCCCN(C)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422067 135653 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 443 8 2 5 2.9 O=C(Nc1cnc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729699 135653 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 443 8 2 5 2.9 O=C(Nc1cnc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
168278342 191127 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5188537 191127 0 None -1 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
67495124 136055 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 7 2 3 4.4 O=C(CCc1cccnc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732149 136055 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 7 2 3 4.4 O=C(CCc1cccnc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL5085818 214968 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)C2)C1=O 10.1016/j.ejmech.2021.113805
CHEMBL5087410 215073 0 None - 1 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1 10.1016/j.ejmech.2021.113805
87422026 135876 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 440 7 3 5 2.6 CNCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3731053 135876 0 None - 1 Human 7.9 pEC50 = 7.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 440 7 3 5 2.6 CNCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
44413524 78029 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 370 4 2 4 4.0 CCc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL209995 78029 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 370 4 2 4 4.0 CCc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
93095777 121706 2 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 415 5 2 2 3.8 O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCC1 10.1016/j.bmc.2015.03.062
CHEMBL3588925 121706 2 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 415 5 2 2 3.8 O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCC1 10.1016/j.bmc.2015.03.062
122180577 121703 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assayAgonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay
ChEMBL 721 13 2 6 4.9 CCC[C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@@H](Cc1ccc2ccccc2c1)N1C[C@@H](Cc2ccc(O)cc2)N(CC2CCCCC2)C(=O)C1=O 10.1016/j.bmc.2015.03.062
CHEMBL3588922 121703 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assayAgonist activity at FPR2 (unknown origin) by Fluo4 florescence based intracellular Ca2+ mobilization assay
ChEMBL 721 13 2 6 4.9 CCC[C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@@H](Cc1ccc2ccccc2c1)N1C[C@@H](Cc2ccc(O)cc2)N(CC2CCCCC2)C(=O)C1=O 10.1016/j.bmc.2015.03.062
67495871 135674 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 456 9 2 6 2.4 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN2CCCC2)C32CC2)n1 nan
CHEMBL3729817 135674 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 456 9 2 6 2.4 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN2CCCC2)C32CC2)n1 nan
67495536 135915 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 10 2 6 2.8 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
CHEMBL3731264 135915 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 10 2 6 2.8 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
145954612 162546 0 None 2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4168567 162546 0 None 2 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
71699059 90650 0 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391286 90650 0 None -3 2 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 417 5 1 5 3.6 Cc1cc(Cc2ccsc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
24776354 94107 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 392 3 1 3 4.8 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL249339 94107 0 None - 1 Human 4.9 pEC50 = 4.9 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 392 3 1 3 4.8 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(Cl)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL5078594 214545 0 None - 1 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None Cc1nn(C)cc1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O 10.1016/j.ejmech.2021.113805
44233646 196400 0 None -1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
CHEMBL562910 196400 0 None -1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 393 7 1 6 2.8 COc1ccc(NC(=O)Cn2nc(C)cc(Cc3cccc(OC)c3)c2=O)cc1 10.1021/jm900592h
67495472 135680 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 444 5 2 2 4.8 CC(C)(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729866 135680 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 444 5 2 2 4.8 CC(C)(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495703 136058 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 463 7 3 3 2.0 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732159 136058 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 463 7 3 3 2.0 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1 nan
89684942 135594 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 4 2 3 3.4 CN1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3729343 135594 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 4 2 3 3.4 CN1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
44413499 78153 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 427 3 2 6 3.9 CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(C2=NCCS2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL210475 78153 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 427 3 2 6 3.9 CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(C2=NCCS2)n1C 10.1016/j.bmcl.2006.04.068
122181411 121888 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay
ChEMBL 415 7 2 4 5.4 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(C)cc2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL3590216 121888 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay
ChEMBL 415 7 2 4 5.4 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(C)cc2)cc1 10.1016/j.bmc.2015.03.062
24776353 94106 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 376 3 1 3 4.3 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL249338 94106 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 376 3 1 3 4.3 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(F)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
87422020 135888 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 440 6 3 5 1.9 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3731133 135888 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 440 6 3 5 1.9 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
44413646 79687 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 420 4 2 6 3.8 CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2cncnc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL211555 79687 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 420 4 2 6 3.8 CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2cncnc2)n1C 10.1016/j.bmcl.2006.04.068
145978177 163037 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 452 8 4 2 4.7 O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4176353 163037 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 452 8 4 2 4.7 O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
145956762 162144 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4162303 162144 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL5088283 215127 3 None - 1 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None N#Cc1ccc(NC(=O)NC2CCN(c3ccccc3F)C2=O)cc1 10.1016/j.ejmech.2021.113805
24776348 94511 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 442 3 1 4 5.0 COc1ccc2[nH]c(C(=O)N3CCC(n4c(C(F)(F)F)nc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
CHEMBL251772 94511 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 442 3 1 4 5.0 COc1ccc2[nH]c(C(=O)N3CCC(n4c(C(F)(F)F)nc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
67495369 135929 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 10 2 6 2.3 CC(=O)c1nc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)co1 nan
CHEMBL3731379 135929 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 10 2 6 2.3 CC(=O)c1nc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)co1 nan
67495671 135652 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 9 2 3 3.5 O=C(NCc1c(F)cc(F)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729697 135652 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 9 2 3 3.5 O=C(NCc1c(F)cc(F)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496282 135301 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 7 1 3 3.7 COCCC(=O)N(C)C[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727591 135301 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 7 1 3 3.7 COCCC(=O)N(C)C[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422036 135749 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 492 8 2 5 3.7 O=C(Nc1nc(Br)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730289 135749 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 492 8 2 5 3.7 O=C(Nc1nc(Br)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495650 135715 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 7 2 4 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCOCC1)C21CC1 nan
CHEMBL3730081 135715 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 7 2 4 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCOCC1)C21CC1 nan
67495428 135435 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 5 2 2 5.4 O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1cccc(F)c1Cl nan
CHEMBL3728360 135435 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 5 2 2 5.4 O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1cccc(F)c1Cl nan
87421982 135811 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 413 5 3 5 2.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCO)C21CC1 nan
CHEMBL3730683 135811 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 413 5 3 5 2.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCO)C21CC1 nan
67495469 135371 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 6 2 3 3.8 CCN1CCCC1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728012 135371 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 6 2 3 3.8 CCN1CCCC1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495506 135580 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 7 2 3 4.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1 nan
CHEMBL3729242 135580 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 7 2 3 4.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1 nan
67495743 136157 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 432 7 2 3 3.4 COCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732748 136157 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 432 7 2 3 3.4 COCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
93095555 121879 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 501 7 2 4 4.0 CCOC(=O)C1CCN(C(=O)[C@H](Cc2ccccc2)NC(=O)Nc2ccc(Br)cc2)CC1 10.1016/j.bmc.2015.03.062
CHEMBL3590207 121879 1 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 501 7 2 4 4.0 CCOC(=O)C1CCN(C(=O)[C@H](Cc2ccccc2)NC(=O)Nc2ccc(Br)cc2)CC1 10.1016/j.bmc.2015.03.062
168295559 192179 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 384 5 2 6 3.1 COc1ccc([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)cc1 10.1021/acsmedchemlett.2c00079
CHEMBL5204580 192179 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 384 5 2 6 3.1 COc1ccc([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)cc1 10.1021/acsmedchemlett.2c00079
168283038 190903 0 None 16 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185462 190903 0 None 16 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
163322252 191856 5 None 26 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5199629 191856 5 None 26 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
67496420 135512 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 8 2 3 4.2 O=C(CCCN1CCCC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728805 135512 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 8 2 3 4.2 O=C(CCCN1CCCC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
162645401 179649 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 422 4 3 3 3.1 CN1CCC(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)CC1 10.1016/j.ejmech.2021.113194
CHEMBL4743451 179649 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 422 4 3 3 3.1 CN1CCC(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)CC1 10.1016/j.ejmech.2021.113194
44236328 195653 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 195653 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
44236328 195653 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 195653 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
168284664 191489 0 None 7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 488 5 2 3 4.9 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5193947 191489 0 None 7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 488 5 2 3 4.9 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21 10.1021/acs.jmedchem.1c02203
122181233 121822 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589947 121822 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
145952664 162409 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 500 9 3 4 4.6 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4166385 162409 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 500 9 3 4 4.6 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
87422011 136225 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 8 2 6 2.8 N#Cc1cnc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
CHEMBL3733176 136225 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 8 2 6 2.8 N#Cc1cnc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
87422037 135716 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 504 8 2 4 3.7 O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730082 135716 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 504 8 2 4 3.7 O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495638 135941 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 7 3 3 4.0 Cc1[nH]ncc1CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731458 135941 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 7 3 3 4.0 Cc1[nH]ncc1CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
44233647 195512 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
CHEMBL554291 195512 0 None 1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 423 8 1 7 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(OC)c(OC)c3)c2=O)c1 10.1021/jm900592h
71699139 90673 0 None -1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 493 5 1 4 4.0 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391443 90673 0 None -1 2 Human 4.8 pEC50 = 4.8 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 493 5 1 4 4.0 Cc1cc(Cc2cccc(Cl)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
67496376 135449 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 7 3 4 4.2 CC(C)(C)OC(=O)NCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728451 135449 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 7 3 4 4.2 CC(C)(C)OC(=O)NCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495567 135565 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 8 2 4 3.6 O=C(Nc1ccc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729170 135565 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 8 2 4 3.6 O=C(Nc1ccc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
87421986 135628 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 492 8 2 5 3.7 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729552 135628 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 492 8 2 5 3.7 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
87421962 135791 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 450 4 3 5 2.5 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 nan
CHEMBL3730548 135791 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 450 4 3 5 2.5 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 nan
57378305 153884 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 424 7 2 10 2.5 COc1cccc(-c2ocnc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
CHEMBL3983228 153884 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 424 7 2 10 2.5 COc1cccc(-c2ocnc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
57378084 148474 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 428 6 2 9 3.1 CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3cccc(Cl)c3)n2)n1 nan
CHEMBL3938248 148474 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 428 6 2 9 3.1 CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3cccc(Cl)c3)n2)n1 nan
285404 80294 10 None - 1 Human 6.8 pEC50 = 6.8 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 368 4 2 5 3.9 CSc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
CHEMBL214216 80294 10 None - 1 Human 6.8 pEC50 = 6.8 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 368 4 2 5 3.9 CSc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
164916034 191666 0 None 6 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196771 191666 0 None 6 2 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
67495076 136015 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 10 2 6 2.3 CC(=O)c1coc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
CHEMBL3731893 136015 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 10 2 6 2.3 CC(=O)c1coc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
71698365 90675 0 None 7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 484 7 2 7 3.9 COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
CHEMBL2391447 90675 0 None 7 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 484 7 2 7 3.9 COc1ccc(Nc2c(C(C)=O)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
122181233 121822 0 None 1 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589947 121822 0 None 1 2 Mouse 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
145952664 162409 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 500 9 3 4 4.6 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4166385 162409 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 500 9 3 4 4.6 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(C)c(F)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
145955803 162622 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 488 8 3 3 4.7 Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F 10.1016/j.ejmech.2017.09.023
CHEMBL4169807 162622 0 None 2 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 488 8 3 3 4.7 Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F 10.1016/j.ejmech.2017.09.023
168283929 191076 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187763 191076 0 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
67496815 135518 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 411 9 2 4 2.7 O=C(NCc1ccco1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728843 135518 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 411 9 2 4 2.7 O=C(NCc1ccco1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
87422329 135913 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 525 7 3 5 4.3 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1 nan
CHEMBL3731251 135913 0 None - 1 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 525 7 3 5 4.3 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1 nan
67496263 135365 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 10 2 3 3.8 O=C(NCCC1=CCCCC1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727975 135365 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 10 2 3 3.8 O=C(NCCC1=CCCCC1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
162644943 179377 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 416 4 3 3 4.2 Cc1cncc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)c1 10.1016/j.ejmech.2021.113194
CHEMBL4739971 179377 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 416 4 3 3 4.2 Cc1cncc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)c1 10.1016/j.ejmech.2021.113194
67495551 135378 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 4 2 4 4.7 CC(C)(C)OC(=O)N1CCCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1 nan
CHEMBL3728062 135378 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 4 2 4 4.7 CC(C)(C)OC(=O)N1CCCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1 nan
67495429 135702 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 7 2 5 3.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1cncn1)C21CC1 nan
CHEMBL3730013 135702 0 None - 1 Human 7.8 pEC50 = 7.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 7 2 5 3.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1cncn1)C21CC1 nan
122181320 121836 0 None 5 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590071 121836 0 None 5 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
122181322 121837 0 None 1 3 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590073 121837 0 None 1 3 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
44233644 196067 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 196067 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
44233644 196067 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 196067 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
145956276 162652 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4170201 162652 0 None -1 2 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
67495817 136175 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 3 3.7 Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(C)c1 nan
CHEMBL3732842 136175 0 None - 1 Human 5.8 pEC50 = 5.8 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 3 3.7 Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(C)c1 nan
67495074 136217 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 7 3 3 2.0 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1 nan
CHEMBL3733127 136217 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 7 3 3 2.0 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1 nan
24776358 154854 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 389 4 1 5 3.6 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2nc3cc(OC)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL400723 154854 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 389 4 1 5 3.6 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2nc3cc(OC)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
87422073 135361 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 464 4 2 5 2.9 NCC1CCN(C(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3727924 135361 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 464 4 2 5 2.9 NCC1CCN(C(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67496407 135550 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 7 3 3 3.1 NCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccc(Br)cc1)C21CC1 nan
CHEMBL3729077 135550 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 7 3 3 3.1 NCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccc(Br)cc1)C21CC1 nan
67495744 135964 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 6 3 3 3.9 Cc1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)[nH]c1C nan
CHEMBL3731599 135964 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 6 3 3 3.9 Cc1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)[nH]c1C nan
145958736 162192 0 None 6 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4162930 162192 0 None 6 2 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
122181231 121681 0 None 2 3 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL3588871 121681 0 None 2 3 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.ejmech.2017.09.023
44233648 195044 0 None 2 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 195044 0 None 2 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
44233648 195044 0 None 2 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 195044 0 None 2 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
67495857 135516 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 6 2 2 3.7 CC(C)CNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728826 135516 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 6 2 2 3.7 CC(C)CNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495889 135528 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 7 2 4 4.5 CC(C)(C)OC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728883 135528 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 7 2 4 4.5 CC(C)(C)OC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
168296342 192423 0 None 2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5208434 192423 0 None 2 2 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
71525548 91682 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
ChEMBL 385 7 4 3 2.2 CC[C@@H](C)[C@@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O 10.1021/ml400179m
CHEMBL2408791 91682 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
ChEMBL 385 7 4 3 2.2 CC[C@@H](C)[C@@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O 10.1021/ml400179m
127034861 135496 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 579 8 3 5 5.3 CC(C)(C)OC(=O)CNc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1 nan
CHEMBL3728708 135496 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 579 8 3 5 5.3 CC(C)(C)OC(=O)CNc1cccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1 nan
168293205 192114 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 430 5 2 3 3.7 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCC(F)(F)CC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5203658 192114 0 None - 1 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 430 5 2 3 3.7 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCC(F)(F)CC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5085666 214956 5 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccc(F)cc2)C1=O 10.1016/j.ejmech.2021.113805
67494874 135425 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 437 9 2 4 3.5 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3728297 135425 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 437 9 2 4 3.5 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
67496426 136210 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 443 5 3 3 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCCN1)C21CC1 nan
CHEMBL3733084 136210 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 443 5 3 3 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCCN1)C21CC1 nan
67495934 135412 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 8 2 3 5.0 CC1CCC(C)N1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728238 135412 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 8 2 3 5.0 CC1CCC(C)N1CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422059 135561 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 466 5 3 5 3.2 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCCN1)C21CC1 nan
CHEMBL3729130 135561 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 466 5 3 5 3.2 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCCN1)C21CC1 nan
67495856 135662 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 525 6 2 3 5.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@H]1CC[C@@H](CN3CCCC3)CC1)C21CC1 nan
CHEMBL3729758 135662 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 525 6 2 3 5.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@H]1CC[C@@H](CN3CCCC3)CC1)C21CC1 nan
67495763 135870 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 528 9 2 4 3.8 CCN1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3731035 135870 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 528 9 2 4 3.8 CCN1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
71525378 91683 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
ChEMBL 403 7 4 3 3.2 CC(C)C[C@H](NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NC(C)(C)C(=O)O 10.1021/ml400179m
CHEMBL2408792 91683 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Modulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assayModulation of FPRL1 (unknown origin) expressed in CHO-Ga16 cells assessed as induction of calcium activity by FLIPR assay
ChEMBL 403 7 4 3 3.2 CC(C)C[C@H](NC(=O)Nc1ccc(C(F)(F)F)cc1)C(=O)NC(C)(C)C(=O)O 10.1021/ml400179m
67495388 135659 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 4 2 2 3.9 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC(F)(F)F)C21CC1 nan
CHEMBL3729752 135659 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 4 2 2 3.9 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC(F)(F)F)C21CC1 nan
67495426 136070 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 474 6 3 3 2.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1 nan
CHEMBL3732225 136070 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 474 6 3 3 2.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1 nan
67495799 135590 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 527 6 2 4 4.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@@H]1CC[C@@H](CN3CCCC3)OC1)C21CC1 nan
CHEMBL3729306 135590 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 527 6 2 4 4.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@@H]1CC[C@@H](CN3CCCC3)OC1)C21CC1 nan
87422009 135943 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 406 5 2 2 3.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1 nan
CHEMBL3731469 135943 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 406 5 2 2 3.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1 nan
67495215 135783 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 417 6 3 3 2.6 CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730502 135783 0 None - 1 Human 8.6 pEC50 = 8.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 417 6 3 3 2.6 CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
162650379 180017 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 446 4 3 4 2.7 O=C(Nc1ccc(Br)nc1)C1C(C(=O)NC2CCNCC2)C2CCC1C21CC1 10.1016/j.ejmech.2021.113194
CHEMBL4747556 180017 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 446 4 3 4 2.7 O=C(Nc1ccc(Br)nc1)C1C(C(=O)NC2CCNCC2)C2CCC1C21CC1 10.1016/j.ejmech.2021.113194
67495567 135565 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 8 2 4 3.6 O=C(Nc1ccc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729170 135565 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 8 2 4 3.6 O=C(Nc1ccc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
162660631 181253 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 416 5 3 3 4.2 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4762142 181253 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 416 5 3 3 4.2 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCCC1 10.1016/j.ejmech.2021.113194
67495925 135519 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 6 2 2 4.4 CC(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728852 135519 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 6 2 2 4.4 CC(C)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495001 135478 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 5 2 2 4.5 O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C1CCCC1 nan
CHEMBL3728585 135478 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 5 2 2 4.5 O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C1CCCC1 nan
67495712 135482 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 456 7 1 2 4.9 CCCN(CC1CC1)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728613 135482 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 456 7 1 2 4.9 CCCN(CC1CC1)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
145953127 162415 0 None 9 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 470 8 4 2 4.9 O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4166447 162415 0 None 9 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 470 8 4 2 4.9 O=C(Nc1ccc(F)cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
89684996 135440 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 557 5 2 4 5.0 CC(C)(C)OC(=O)N1CCC(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3728389 135440 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 557 5 2 4 5.0 CC(C)(C)OC(=O)N1CCC(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
1022 1656 55 None -5011 3 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
443295 1656 55 None -5011 3 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
CHEMBL267179 1656 55 None -5011 3 Human 4.7 pEC50 = 4.7 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL None None None None 10.1021/jm900592h
67495715 135642 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 9 2 3 3.9 O=C(NCc1cccc(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729633 135642 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 9 2 3 3.9 O=C(NCc1cccc(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495856 136091 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 525 6 2 3 5.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@H]1CC[C@H](CN3CCCC3)CC1)C21CC1 nan
CHEMBL3732371 136091 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 525 6 2 3 5.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)N[C@H]1CC[C@H](CN3CCCC3)CC1)C21CC1 nan
67495495 135305 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 455 10 2 5 3.1 CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3CC[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1 nan
CHEMBL3727620 135305 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 455 10 2 5 3.1 CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3CC[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1 nan
67495271 135748 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 460 7 3 3 3.7 CC(C)C[C@@H](CO)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730283 135748 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 460 7 3 3 3.7 CC(C)C[C@@H](CO)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
57378083 151226 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 476 6 2 9 3.8 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(C(F)(F)F)c2)o1 nan
CHEMBL3960228 151226 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 476 6 2 9 3.8 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(C(F)(F)F)c2)o1 nan
11262 381 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(cc1)NC(=O)N[C@@H](C(=O)NCC1(CCCCC1)c1cccnc1)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2014.12.007
122181321 381 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(cc1)NC(=O)N[C@@H](C(=O)NCC1(CCCCC1)c1cccnc1)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2014.12.007
CHEMBL3590072 381 0 None - 1 Mouse 5.7 pEC50 = 5.7 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(cc1)NC(=O)N[C@@H](C(=O)NCC1(CCCCC1)c1cccnc1)Cc1c[nH]c2c1cccc2 10.1016/j.bmc.2014.12.007
44236326 195299 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 195299 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44236326 195299 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 195299 0 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
67495690 135337 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 506 9 2 5 3.3 O=C(NCc1cnc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727792 135337 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 506 9 2 5 3.3 O=C(NCc1cnc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495155 135802 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 514 8 2 4 2.6 CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3730632 135802 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 514 8 2 4 2.6 CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67496425 135434 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 532 8 3 3 4.5 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1 nan
CHEMBL3728352 135434 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 532 8 3 3 4.5 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1 nan
67495953 135704 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 4 2 2 4.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCCC1)C21CC1 nan
CHEMBL3730033 135704 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 4 2 2 4.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCCC1)C21CC1 nan
CHEMBL5090603 215251 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None CC(C)(C)OC(=O)N1CCC(CN2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)CC1 10.1016/j.ejmech.2021.113805
89685004 135751 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 4 2 4 4.7 CC(C)(C)OC(=O)N1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3730306 135751 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 4 2 4 4.7 CC(C)(C)OC(=O)N1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
87422027 135338 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 494 8 2 5 3.9 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727795 135338 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 494 8 2 5 3.9 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496050 135682 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 9 3 3 3.5 NCCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3729885 135682 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 9 3 3 3.5 NCCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2CC[C@H]1C21CC1 nan
67495190 136183 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 6 2 4 2.9 COC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732895 136183 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 6 2 4 2.9 COC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
168288195 191738 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)no2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5197701 191738 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)no2)c(F)c1 10.1021/acsmedchemlett.2c00079
67495923 135471 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 7 3 3 3.4 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728553 135471 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 7 3 3 3.4 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495196 135577 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 10 2 5 3.4 CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
CHEMBL3729225 135577 0 None - 1 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 10 2 5 3.4 CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
CHEMBL5085435 214944 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(CC2CCN(Cc3ccccc3)CC2)C1=O 10.1016/j.ejmech.2021.113805
87421992 135834 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 464 8 2 5 4.1 O=C(Nc1nc2ccccc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730819 135834 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 464 8 2 5 4.1 O=C(Nc1nc2ccccc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
44413534 138354 0 None -4 4 Human 7.6 pEC50 = 7.6 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.bmcl.2006.04.068
CHEMBL377226 138354 0 None -4 4 Human 7.6 pEC50 = 7.6 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.bmcl.2006.04.068
67495918 135462 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 4 3.6 CC(=O)c1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3728508 135462 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 4 3.6 CC(=O)c1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
67495331 135470 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 5 3 3 2.8 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 nan
CHEMBL3728546 135470 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 5 3 3 2.8 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 nan
67495564 136237 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 7 3 4 3.2 NS(=O)(=O)c1ccc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
CHEMBL3733264 136237 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 7 3 4 3.2 NS(=O)(=O)c1ccc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
CHEMBL5075000 214330 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCNCC2)C1=O 10.1016/j.ejmech.2021.113805
122181232 121821 0 None 8 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589946 121821 0 None 8 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
122181234 121823 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589948 121823 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
122181324 121839 0 None -2 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 542 9 4 3 6.1 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590075 121839 0 None -2 2 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 542 9 4 3 6.1 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
168295570 192180 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 378 3 2 4 2.9 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3nc(Cl)ccc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5204594 192180 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 378 3 2 4 2.9 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3nc(Cl)ccc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
168274924 190245 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5175543 190245 0 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5080179 214644 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None CC(C)(C)OC(=O)N1CC(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1 10.1016/j.ejmech.2021.113805
67496353 135828 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1ccc(Br)c(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730781 135828 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1ccc(Br)c(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495785 135275 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 9 1 4 3.3 COCCN(CCOC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727426 135275 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 9 1 4 3.3 COCCN(CCOC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422136 135505 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 390 6 3 4 1.7 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Cl)nc2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3728771 135505 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 390 6 3 4 1.7 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Cl)nc2)[C@@H]2CC[C@H]1C21CC1 nan
67495409 135552 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729082 135552 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496020 135845 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 7 2 4 4.1 CCn1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1C nan
CHEMBL3730881 135845 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 7 2 4 4.1 CCn1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1C nan
87422334 136048 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 4 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 nan
CHEMBL3732094 136048 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 4 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCNCC1)C21CC1 nan
122181231 121681 0 None -2 3 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3588871 121681 0 None -2 3 Mouse 6.6 pEC50 = 6.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
168286767 191658 0 None 53 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196551 191658 0 None 53 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
67495496 135770 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 3 3 1.9 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730424 135770 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 3 3 1.9 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
44233905 196310 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
CHEMBL562380 196310 0 None -1 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1021/jm900592h
44413496 139738 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 386 4 2 6 3.4 CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cncnc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL379853 139738 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 386 4 2 6 3.4 CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cncnc2)n1C 10.1016/j.bmcl.2006.04.068
92881734 121880 1 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 463 5 2 2 4.8 O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc21 10.1016/j.bmc.2015.03.062
CHEMBL3590208 121880 1 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 463 5 2 2 4.8 O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCc2ccccc21 10.1016/j.bmc.2015.03.062
162676377 183323 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 402 4 3 3 3.9 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cccnc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4797594 183323 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 402 4 3 3 3.9 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cccnc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL5085435 214944 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(CC2CCN(Cc3ccccc3)CC2)C1=O 10.1016/j.ejmech.2021.113805
162425412 191044 0 None 21 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 386 5 2 6 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccccc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5187399 191044 0 None 21 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 386 5 2 6 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccccc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
146597617 191942 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2ncc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5201015 191942 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2ncc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
168281597 191246 0 None 50 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5190571 191246 0 None 50 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
122181318 121834 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 524 9 4 3 5.9 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590069 121834 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 524 9 4 3 5.9 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
122181325 121840 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 542 9 4 3 6.1 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590076 121840 0 None - 1 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 542 9 4 3 6.1 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
145952485 162829 0 None 2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4172968 162829 0 None 2 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
168288891 191542 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2noc(-c3ccc(Cl)cc3)n2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5194850 191542 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2noc(-c3ccc(Cl)cc3)n2)c(F)c1 10.1021/acsmedchemlett.2c00079
67496417 135976 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 6 2 4 4.3 Cc1nc(CC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cs1 nan
CHEMBL3731676 135976 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 6 2 4 4.3 Cc1nc(CC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cs1 nan
127036712 136249 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 7 3 4 1.3 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cn2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3733330 136249 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 7 3 4 1.3 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cn2)[C@@H]2C=C[C@H]1C21CC1 nan
164916036 191563 0 None 147 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5195186 191563 0 None 147 2 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
67495766 135520 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 459 7 3 3 3.0 CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728857 135520 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 459 7 3 3 3.0 CC(C)(CN)CNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495515 136240 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 5 3 3 2.2 C[C@H](NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(N)=O nan
CHEMBL3733280 136240 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 5 3 3 2.2 C[C@H](NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(N)=O nan
122181319 121835 0 None 7 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 524 9 4 3 5.9 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590070 121835 0 None 7 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 524 9 4 3 5.9 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
67496719 136277 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 10 2 4 3.8 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Cl nan
CHEMBL3728133 136277 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 10 2 4 3.8 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Cl nan
CHEMBL3733972 136277 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 10 2 4 3.8 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1Cl nan
67495526 135573 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 491 9 2 4 4.3 O=C(Nc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729208 135573 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 491 9 2 4 4.3 O=C(Nc1ccc(OC(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495947 135553 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 6 2 3 2.9 CN(C)CC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729083 135553 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 6 2 3 2.9 CN(C)CC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67496240 135960 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 545 9 3 4 5.0 CC(C)(C)OC(=O)NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731561 135960 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 545 9 3 4 5.0 CC(C)(C)OC(=O)NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
122181320 121836 0 None 5 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590071 121836 0 None 5 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL5084374 214888 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(CC2CCNCC2)C1=O 10.1016/j.ejmech.2021.113805
168279295 191022 0 None 91 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187135 191022 0 None 91 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
24776357 94167 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 386 4 1 3 4.7 CCc1ccc2[nH]c(C(=O)N3CC[C@@H](n4c(CC)nc5ccccc54)C3)cc2c1 10.1016/j.bmcl.2007.09.043
CHEMBL249742 94167 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 386 4 1 3 4.7 CCc1ccc2[nH]c(C(=O)N3CC[C@@H](n4c(CC)nc5ccccc54)C3)cc2c1 10.1016/j.bmcl.2007.09.043
CHEMBL5085818 214968 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)C2)C1=O 10.1016/j.ejmech.2021.113805
24776349 154965 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 450 4 1 4 5.7 COc1ccc2[nH]c(C(=O)N3CCC(n4c(-c5ccccc5)nc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
CHEMBL401313 154965 0 None - 1 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 450 4 1 4 5.7 COc1ccc2[nH]c(C(=O)N3CCC(n4c(-c5ccccc5)nc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
162668376 182467 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 407 5 4 5 1.7 O=C(Nc1ccc(Br)cc1)NC1(C(=O)NCc2nn[nH]n2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4786842 182467 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 407 5 4 5 1.7 O=C(Nc1ccc(Br)cc1)NC1(C(=O)NCc2nn[nH]n2)CCCC1 10.1016/j.ejmech.2021.113194
71699063 90671 0 None 1 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 454 6 2 5 2.6 Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391440 90671 0 None 1 2 Human 4.6 pEC50 = 4.6 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 454 6 2 5 2.6 Cc1cc(Cc2ccc(C(N)=O)cc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
67496228 135606 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 402 8 3 6 1.3 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN)C32CC2)n1 nan
CHEMBL3729427 135606 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 402 8 3 6 1.3 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN)C32CC2)n1 nan
5308652 138625 5 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 352 4 2 5 3.1 COc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
CHEMBL377642 138625 5 None 1 2 Human 5.6 pEC50 = 5.6 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 352 4 2 5 3.1 COc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
67496454 135763 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 4.5 Cc1cc(Br)ccc1NC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730378 135763 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 4.5 Cc1cc(Br)ccc1NC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495449 135593 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 535 9 2 3 4.2 O=C(NCc1c(F)cc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729342 135593 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 535 9 2 3 4.2 O=C(NCc1c(F)cc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495561 136192 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 453 10 2 5 2.9 CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1 nan
CHEMBL3732960 136192 0 None - 1 Human 7.6 pEC50 = 7.6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 453 10 2 5 2.9 CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1 nan
CHEMBL5076199 214397 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None Cc1nn(-c2ccccc2)c(C)c1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O 10.1016/j.ejmech.2021.113805
71699062 90669 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 412 5 1 5 2.9 Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391439 90669 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 412 5 1 5 2.9 Cc1cc(Cc2cccnc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
71699143 90679 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 470 6 2 6 3.2 COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391450 90679 0 None 3 2 Human 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 470 6 2 6 3.2 COc1cccc(C(=O)Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
122181322 121837 0 None -4 3 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590073 121837 0 None -4 3 Mouse 5.6 pEC50 = 5.6 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL5070452 214214 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)CC2)C1=O 10.1016/j.ejmech.2021.113805
67495297 136206 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 9 2 6 1.9 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN(C)C)C32CC2)n1 nan
CHEMBL3733076 136206 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 9 2 6 1.9 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN(C)C)C32CC2)n1 nan
67495865 135283 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 2 3 2.6 CN(C)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727453 135283 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 2 3 2.6 CN(C)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495510 136262 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1F nan
CHEMBL3733253 136262 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1F nan
CHEMBL3733939 136262 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1F nan
145949892 162796 0 None 2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4172556 162796 0 None 2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
67495961 136287 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 11 2 4 3.5 CCOc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3730203 136287 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 11 2 4 3.5 CCOc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3733983 136287 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 11 2 4 3.5 CCOc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
71698442 90676 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 336 3 2 5 1.5 Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391448 90676 0 None -3 2 Human 4.5 pEC50 = 4.5 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 336 3 2 5 1.5 Cc1cc(N)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
67495965 135663 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 8 3 6 0.8 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)n1 nan
CHEMBL3729761 135663 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 8 3 6 0.8 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)n1 nan
67495646 136129 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 512 6 1 2 5.6 CN(C[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)Cc1ccccc1Cl nan
CHEMBL3732583 136129 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 512 6 1 2 5.6 CN(C[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(=O)Cc1ccccc1Cl nan
67495824 135756 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 444 5 2 3 3.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCCO1)C21CC1 nan
CHEMBL3730354 135756 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 444 5 2 3 3.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCCO1)C21CC1 nan
67496189 135839 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 6 3 3 2.5 CNC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730852 135839 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 6 3 3 2.5 CNC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
127024133 135502 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 472 5 3 3 3.9 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCC(O)CC1)C21CC1 nan
CHEMBL3728753 135502 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 472 5 3 3 3.9 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCC(O)CC1)C21CC1 nan
67495181 135350 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 459 6 2 3 2.8 CN(C)C(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727840 135350 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 459 6 2 3 2.8 CN(C)C(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495807 135747 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 7 2 3 4.1 CCSCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730279 135747 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 7 2 3 4.1 CCSCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
127035356 135474 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 437 6 2 4 3.1 CC(C)CNC(=O)[C@H]1[C@H](C(=O)NCc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728562 135474 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 437 6 2 4 3.1 CC(C)CNC(=O)[C@H]1[C@H](C(=O)NCc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
67495379 136039 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 501 10 2 3 4.8 CCN(CC)CCCC(C)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732049 136039 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 501 10 2 3 4.8 CCN(CC)CCCC(C)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
16036926 77631 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 448 3 2 4 3.7 Cc1c(NC(=O)Nc2ccc(I)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL208884 77631 2 None - 1 Human 7.5 pEC50 = 7.5 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 448 3 2 4 3.7 Cc1c(NC(=O)Nc2ccc(I)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
44413525 139603 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 447 5 2 6 5.2 CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cnc4ccccc4c3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
CHEMBL379762 139603 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 447 5 2 6 5.2 CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cnc4ccccc4c3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
162645814 179612 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 404 6 3 3 4.0 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
CHEMBL4742937 179612 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 404 6 3 3 4.0 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
67495531 136250 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 8 3 3 3.5 NCCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccc(Br)cc1)C21CC1 nan
CHEMBL3733340 136250 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 8 3 3 3.5 NCCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccc(Br)cc1)C21CC1 nan
122180578 121705 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 555 7 4 5 3.8 CNOC(=O)C1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(Br)cc2)CC1C 10.1016/j.bmc.2015.03.062
CHEMBL3588924 121705 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 555 7 4 5 3.8 CNOC(=O)C1CCN(C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)Nc2ccc(Br)cc2)CC1C 10.1016/j.bmc.2015.03.062
122180579 121709 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 397 6 2 3 4.2 CSc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCCC2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL3588928 121709 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 397 6 2 3 4.2 CSc1ccc(NC(=O)N[C@@H](Cc2ccccc2)C(=O)N2CCCCC2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL5076914 214446 4 None 1 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccccc2)C1=O 10.1016/j.ejmech.2021.113805
145951856 162867 0 None 8 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4173645 162867 0 None 8 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
872695 19011 11 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 270 5 2 2 3.1 COc1ccc(CCNC(=O)Nc2ccccc2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL1288648 19011 11 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 270 5 2 2 3.1 COc1ccc(CCNC(=O)Nc2ccccc2)cc1 10.1016/j.bmc.2015.03.062
145955803 162622 0 None 2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 488 8 3 3 4.7 Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F 10.1016/j.ejmech.2017.09.023
CHEMBL4169807 162622 0 None 2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 488 8 3 3 4.7 Cc1ccc(C2(CNC(=O)[C@H](Cc3ccc(C#N)cc3)NC(=O)Nc3ccc(F)cc3)CC2)cc1F 10.1016/j.ejmech.2017.09.023
67496358 135979 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 535 9 2 3 4.2 O=C(NCc1cc(F)c(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731680 135979 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 535 9 2 3 4.2 O=C(NCc1cc(F)c(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495154 136145 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 5 1 4 4.0 Cc1cc(C(=O)N(C)C[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nn1C nan
CHEMBL3732650 136145 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 5 1 4 4.0 Cc1cc(C(=O)N(C)C[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nn1C nan
87422008 135329 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 478 7 2 5 3.3 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1 nan
CHEMBL3727729 135329 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 478 7 2 5 3.3 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1 nan
67496616 135733 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 6 2 3 3.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(=O)N1CCCC1)C21CC1 nan
CHEMBL3730211 135733 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 6 2 3 3.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(=O)N1CCCC1)C21CC1 nan
127036714 136063 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 402 7 3 4 1.2 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Cl)nc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732192 136063 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 402 7 3 4 1.2 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Cl)nc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495716 136265 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 455 9 2 3 3.8 O=C(NCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728125 136265 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 455 9 2 3 3.8 O=C(NCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733942 136265 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 455 9 2 3 3.8 O=C(NCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
44413547 79798 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 368 4 2 4 3.8 CCc1c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL212113 79798 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 368 4 2 4 3.8 CCc1c(NC(=O)Nc2ccc(C)c(F)c2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
122181323 121838 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590074 121838 0 None 2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
168283359 190788 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5183856 190788 0 None 5 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
67495617 135481 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 6 2 2 4.1 O=C(CC1CC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728604 135481 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 6 2 2 4.1 O=C(CC1CC1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495528 135398 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 451 11 2 4 3.0 O=C(NCCOc1ccccc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728166 135398 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 451 11 2 4 3.0 O=C(NCCOc1ccccc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
146597625 191238 1 None 47 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5190385 191238 1 None 47 2 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
67496311 135460 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 383 7 3 4 1.5 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)cc1 nan
CHEMBL3728506 135460 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 383 7 3 4 1.5 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)cc1 nan
67495168 135657 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 9 2 3 3.9 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729722 135657 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 9 2 3 3.9 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
57378196 144400 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 492 7 2 10 3.7 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(OC(F)(F)F)c2)o1 nan
CHEMBL3906325 144400 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 492 7 2 10 3.7 Cc1nc(C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c(-c2cccc(OC(F)(F)F)c2)o1 nan
2165902 121883 11 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 341 6 2 4 3.9 CCc1ccc(NC(=O)CSc2nc3cc(OC)ccc3[nH]2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL3590211 121883 11 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 341 6 2 4 3.9 CCc1ccc(NC(=O)CSc2nc3cc(OC)ccc3[nH]2)cc1 10.1016/j.bmc.2015.03.062
67495032 135911 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 10 2 6 2.8 CC(=O)c1nc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cs1 nan
CHEMBL3731244 135911 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 10 2 6 2.8 CC(=O)c1nc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cs1 nan
CHEMBL5084374 214888 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(CC2CCNCC2)C1=O 10.1016/j.ejmech.2021.113805
67495652 136241 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 505 9 2 4 3.9 O=C(NCc1csc(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733287 136241 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 505 9 2 4 3.9 O=C(NCc1csc(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
145956361 161987 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4159569 161987 0 None -2 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
67496430 135664 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 368 6 3 4 1.1 Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)nc1 nan
CHEMBL3729765 135664 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 368 6 3 4 1.1 Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)nc1 nan
87422315 135324 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 441 5 3 5 2.8 CC(C)(CO)NC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3727702 135324 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 441 5 3 5 2.8 CC(C)(CO)NC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
67495430 135315 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 532 7 2 4 4.9 Cn1c(CCC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nc2ccccc21 nan
CHEMBL3727668 135315 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 532 7 2 4 4.9 Cn1c(CCC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)nc2ccccc21 nan
67495295 135737 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 459 8 2 3 3.7 CCN(CC)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730231 135737 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 459 8 2 3 3.7 CCN(CC)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495822 135855 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 7 2 2 4.5 CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730944 135855 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 430 7 2 2 4.5 CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
24776351 94067 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 388 4 1 4 4.2 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL249132 94067 0 None - 1 Human 7.5 pEC50 = 7.5 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 388 4 1 4 4.2 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
168280238 190930 0 None 6 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185921 190930 0 None 6 2 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
145956361 161987 0 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4159569 161987 0 None -2 2 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
87422107 136292 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 506 8 2 4 4.0 O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729273 136292 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 506 8 2 4 4.0 O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733988 136292 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 506 8 2 4 4.0 O=C(Nc1cnc(Br)c(F)c1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL5070452 214214 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)CC2)C1=O 10.1016/j.ejmech.2021.113805
67496611 135686 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 7 3 3 2.2 CNCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729916 135686 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 7 3 3 2.2 CNCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
168284711 191578 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc(-c3ccc(Cl)cc3)no2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5195336 191578 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nc(-c3ccc(Cl)cc3)no2)c(F)c1 10.1021/acsmedchemlett.2c00079
24776352 154966 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 388 4 1 4 4.2 CCc1nc2ccccc2n1[C@H]1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL401314 154966 0 None - 1 Human 5.5 pEC50 = 5.5 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 388 4 1 4 4.2 CCc1nc2ccccc2n1[C@H]1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
67496253 135906 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 401 10 2 3 3.0 CC(C)CCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731214 135906 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 401 10 2 3 3.0 CC(C)CCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
87422039 135389 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 413 5 2 4 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1 nan
CHEMBL3728109 135389 0 None - 1 Human 6.5 pEC50 = 6.5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 413 5 2 4 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1 nan
67495594 135437 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 387 10 2 3 2.7 CCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728370 135437 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 387 10 2 3 2.7 CCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495485 136137 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 8 2 5 3.7 CC(C)(C)c1cc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1 nan
CHEMBL3732612 136137 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 8 2 5 3.7 CC(C)(C)c1cc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1 nan
162653376 180361 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 403 4 3 4 3.3 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cncnc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4751781 180361 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 403 4 3 4 3.3 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cncnc2)CCCC1 10.1016/j.ejmech.2021.113194
67495890 135448 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 493 7 3 3 3.7 NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
CHEMBL3728437 135448 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 493 7 3 3 3.7 NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
67495438 136123 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 519 8 2 3 4.9 O=C(Nc1ccc(Br)c(Cl)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732539 136123 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 519 8 2 3 4.9 O=C(Nc1ccc(Br)c(Cl)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
162644626 179368 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 436 5 3 3 3.3 CN1CCC(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)CC1 10.1016/j.ejmech.2021.113194
CHEMBL4739874 179368 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 436 5 3 3 3.3 CN1CCC(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)CC1 10.1016/j.ejmech.2021.113194
127035355 135932 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 385 7 2 5 2.1 CC(=O)c1coc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCC(C)C)C32CC2)n1 nan
CHEMBL3731384 135932 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 385 7 2 5 2.1 CC(=O)c1coc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCC(C)C)C32CC2)n1 nan
146649326 191974 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 436 5 2 6 3.8 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)s2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5201495 191974 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 436 5 2 6 3.8 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)s2)c(F)c1 10.1021/acsmedchemlett.2c00079
67495333 135613 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 6 2 4 5.3 O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1cnoc1-c1ccccc1 nan
CHEMBL3729471 135613 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 6 2 4 5.3 O=C(NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)c1cnoc1-c1ccccc1 nan
CHEMBL5085818 214968 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)C2)C1=O 10.1016/j.ejmech.2021.113805
2215592 79799 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 347 3 2 5 3.0 Cc1c(NC(=O)Nc2ccc(C#N)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL212116 79799 10 None - 1 Human 5.4 pEC50 = 5.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 347 3 2 5 3.0 Cc1c(NC(=O)Nc2ccc(C#N)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
168293191 192107 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 416 6 2 7 2.7 COc1ccc(-c2nnc(N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(OC)cc3F)o2)cc1 10.1021/acsmedchemlett.2c00079
CHEMBL5203596 192107 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 416 6 2 7 2.7 COc1ccc(-c2nnc(N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(OC)cc3F)o2)cc1 10.1021/acsmedchemlett.2c00079
127035212 135544 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 5 3 3 3.5 CNC(=O)[C@H](NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(C)(C)C nan
CHEMBL3729032 135544 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 5 3 3 3.5 CNC(=O)[C@H](NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1)C(C)(C)C nan
CHEMBL5088171 215120 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(c2cnn(-c3ccncc3)c2)C1=O 10.1016/j.ejmech.2021.113805
67495542 135669 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 542 8 2 4 3.3 CC(=O)N1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3729805 135669 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 542 8 2 4 3.3 CC(=O)N1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
168282231 190938 0 None 16 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185982 190938 0 None 16 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
44233905 196310 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2021.113194
CHEMBL562380 196310 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 (unknown origin) by calcium mobilization assayAgonist activity at FPR2 (unknown origin) by calcium mobilization assay
ChEMBL 441 6 1 5 3.6 COc1ccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2021.113194
122181319 121835 0 None -7 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 524 9 4 3 5.9 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590070 121835 0 None -7 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 524 9 4 3 5.9 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
44236326 195299 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551589 195299 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 441 6 1 5 3.6 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
67495653 135725 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 553 8 2 3 5.2 O=C(Nc1ccc(Br)c(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730156 135725 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 553 8 2 3 5.2 O=C(Nc1ccc(Br)c(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495892 135996 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 7 3 6 1.9 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCC2CCNCC2)C32CC2)n1 nan
CHEMBL3731785 135996 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 7 3 6 1.9 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCC2CCNCC2)C32CC2)n1 nan
CHEMBL5093348 215401 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(c3ncccn3)CC2)C1=O 10.1016/j.ejmech.2021.113805
162673364 182975 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 394 5 4 3 2.2 O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CNC1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4793549 182975 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 394 5 4 3 2.2 O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CNC1)C1CCCC1 10.1016/j.ejmech.2021.113194
67495440 136263 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 10 2 4 3.3 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F nan
CHEMBL3729027 136263 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 10 2 4 3.3 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F nan
CHEMBL3733940 136263 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 10 2 4 3.3 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1F nan
122181320 121836 0 None -5 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590071 121836 0 None -5 2 Mouse 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
145958736 162192 0 None 6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4162930 162192 0 None 6 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 508 8 3 3 5.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
67495563 136282 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 10 2 3 3.5 Cc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3728150 136282 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 10 2 3 3.5 Cc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3733978 136282 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 10 2 3 3.5 Cc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
67496272 135416 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 579 7 3 4 5.6 CC(C)(C)OC(=O)NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
CHEMBL3728252 135416 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 579 7 3 4 5.6 CC(C)(C)OC(=O)NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
122180580 121710 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 473 6 4 3 3.0 O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)NN1CCCCNC1=O 10.1016/j.bmc.2015.03.062
CHEMBL3588929 121710 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 473 6 4 3 3.0 O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)NN1CCCCNC1=O 10.1016/j.bmc.2015.03.062
67495873 135488 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 514 8 2 4 3.4 CN1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3728649 135488 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 514 8 2 4 3.4 CN1CCN(CCCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67495579 135989 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 7 2 4 3.8 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCn1ccnc1)C21CC1 nan
CHEMBL3731739 135989 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 7 2 4 3.8 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCn1ccnc1)C21CC1 nan
67495722 135703 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 443 4 3 3 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCNC1)C21CC1 nan
CHEMBL3730024 135703 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 443 4 3 3 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CCCNC1)C21CC1 nan
67496623 136113 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 6 3 4 3.9 CC(C)(C)OC(=O)NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732493 136113 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 6 3 4 3.9 CC(C)(C)OC(=O)NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495493 136291 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC(F)(F)C1)C21CC1 nan
CHEMBL3729299 136291 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC(F)(F)C1)C21CC1 nan
CHEMBL3733987 136291 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCC(F)(F)C1)C21CC1 nan
127035730 135443 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 461 8 4 4 2.3 CC(CO)NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728401 135443 0 None - 1 Human 8.4 pEC50 = 8.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 461 8 4 4 2.3 CC(CO)NCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495138 135467 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 434 7 2 3 3.6 COCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3728536 135467 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 434 7 2 3 3.6 COCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2CC[C@H]1C21CC1 nan
67496172 135801 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 472 6 3 3 2.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1 nan
CHEMBL3730629 135801 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 472 6 3 3 2.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1 nan
67495286 135920 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 7 2 3 3.8 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1 nan
CHEMBL3731297 135920 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 7 2 3 3.8 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1 nan
11418989 121707 1 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 429 5 2 2 4.2 O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1 10.1016/j.bmc.2015.03.062
CHEMBL3588926 121707 1 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 429 5 2 2 4.2 O=C(Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1 10.1016/j.bmc.2015.03.062
168272852 190639 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 402 5 2 6 3.2 COc1ccc([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5181627 190639 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 402 5 2 6 3.2 COc1ccc([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
168282219 190924 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 378 3 2 4 2.9 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3cc(Cl)cnc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5185842 190924 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 378 3 2 4 2.9 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3cc(Cl)cnc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
67495368 136085 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 535 9 2 3 4.2 O=C(NCc1ccc(Br)c(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732345 136085 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 535 9 2 3 4.2 O=C(NCc1ccc(Br)c(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495210 136274 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 426 9 2 5 2.4 Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1 nan
CHEMBL3730873 136274 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 426 9 2 5 2.4 Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1 nan
CHEMBL3733951 136274 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 426 9 2 5 2.4 Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1 nan
6268 309 7 None 2 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 10.1016/j.bmc.2015.03.062
727787 309 7 None 2 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 10.1016/j.bmc.2015.03.062
CHEMBL1289260 309 7 None 2 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 10.1016/j.bmc.2015.03.062
CHEMBL5090603 215251 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None CC(C)(C)OC(=O)N1CCC(CN2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)CC1 10.1016/j.ejmech.2021.113805
CHEMBL5076199 214397 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None Cc1nn(-c2ccccc2)c(C)c1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O 10.1016/j.ejmech.2021.113805
44236328 195653 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL556625 195653 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 397 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/jm900592h
1416500 121881 13 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 391 5 2 4 4.1 COc1ccc2[nH]c(SCC(=O)Nc3ccccc3Br)nc2c1 10.1016/j.bmc.2015.03.062
CHEMBL3590209 121881 13 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 391 5 2 4 4.1 COc1ccc2[nH]c(SCC(=O)Nc3ccccc3Br)nc2c1 10.1016/j.bmc.2015.03.062
CHEMBL5080179 214644 0 None - 1 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None CC(C)(C)OC(=O)N1CC(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1 10.1016/j.ejmech.2021.113805
168282160 190826 0 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184490 190826 0 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
145956762 162144 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4162303 162144 0 None 1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
67495622 135909 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 547 9 2 3 3.7 O=C(NCc1ccc(I)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731221 135909 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 547 9 2 3 3.7 O=C(NCc1ccc(I)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
44413508 78545 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 398 5 2 7 3.5 CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cncnc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
CHEMBL211220 78545 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 398 5 2 7 3.5 CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3cncnc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
CHEMBL5076914 214446 4 None 1 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccccc2)C1=O 10.1016/j.ejmech.2021.113805
122181322 121837 0 None 1 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590073 121837 0 None 1 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
71698531 90644 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 4.9 COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391258 90644 0 None 2 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 4.9 COc1cccc(Cc2cc(-c3ccccc3)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
24776341 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1016/j.bmcl.2006.04.068
5831 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1016/j.bmcl.2006.04.068
CHEMBL379761 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1016/j.bmcl.2006.04.068
44413498 140151 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 469 4 2 5 5.5 CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL380389 140151 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 469 4 2 5 5.5 CC(C)c1c(NC(=O)Nc2ccc(C(F)(F)F)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C 10.1016/j.bmcl.2006.04.068
87422121 135320 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 425 6 2 5 2.4 COCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727690 135320 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 425 6 2 5 2.4 COCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
24776341 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1016/j.bmcl.2007.09.043
5831 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1016/j.bmcl.2007.09.043
CHEMBL379761 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1016/j.bmcl.2007.09.043
127037326 135977 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 478 8 2 5 4.4 Cc1nsc2cc(NC(=O)[C@@H]3[C@@H]4C=C[C@H]([C@H]3C(=O)NCCCCN3CCCC3)C43CC3)ccc12 nan
CHEMBL3731677 135977 0 None - 1 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 478 8 2 5 4.4 Cc1nsc2cc(NC(=O)[C@@H]3[C@@H]4C=C[C@H]([C@H]3C(=O)NCCCCN3CCCC3)C43CC3)ccc12 nan
87422278 135567 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 6 3 5 3.4 NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
CHEMBL3729184 135567 0 None - 1 Human 7.4 pEC50 = 7.4 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 486 6 3 5 3.4 NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
122181322 121837 0 None 1 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590073 121837 0 None 1 3 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
168279956 191059 0 None 4 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187563 191059 0 None 4 2 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
44232675 195640 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
CHEMBL556485 195640 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
44232675 195640 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
CHEMBL556485 195640 0 None -1 2 Human 5.4 pEC50 = 5.4 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 407 6 1 7 2.5 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc4c(c3)OCO4)c2=O)c1 10.1021/jm900592h
67495000 135403 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 435 9 2 3 3.4 Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3728190 135403 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 435 9 2 3 3.4 Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
67495216 135856 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 535 9 2 3 4.2 O=C(NCc1cc(F)c(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730955 135856 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 535 9 2 3 4.2 O=C(NCc1cc(F)c(Br)c(F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
87422168 135300 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 8 2 5 3.2 Cc1cnc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
CHEMBL3727588 135300 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 8 2 5 3.2 Cc1cnc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
127037112 135926 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 7 3 2 5.4 O=C(CCc1cc2ccccc2[nH]1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731359 135926 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 7 3 2 5.4 O=C(CCc1cc2ccccc2[nH]1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422233 135404 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 540 8 3 6 4.3 CC(C)(C)OC(=O)NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3728194 135404 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 540 8 3 6 4.3 CC(C)(C)OC(=O)NCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
67495168 135657 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 9 2 3 3.9 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729722 135657 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 9 2 3 3.9 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495643 135938 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 3.7 O=C(CCCN1CCCC1=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731426 135938 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 8 2 3 3.7 O=C(CCCN1CCCC1=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
122181412 121889 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay
ChEMBL 431 8 2 5 5.1 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(OC)cc2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL3590217 121889 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assayAgonist activity at human FPR2 expressed in rat RBL-2H3 cells by intracellular Ca2+ mobilization assay
ChEMBL 431 8 2 5 5.1 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(OC)cc2)cc1 10.1016/j.bmc.2015.03.062
2302157 19304 8 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 373 7 2 6 3.3 COc1ccc2[nH]c(SCC(=O)Nc3ccc(OC)c(OC)c3)nc2c1 10.1016/j.bmc.2015.03.062
CHEMBL1290698 19304 8 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 373 7 2 6 3.3 COc1ccc2[nH]c(SCC(=O)Nc3ccc(OC)c(OC)c3)nc2c1 10.1016/j.bmc.2015.03.062
67496188 136072 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 9 2 3 3.9 O=C(NCc1cccc(Cl)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732252 136072 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 9 2 3 3.9 O=C(NCc1cccc(Cl)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495059 135429 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 9 2 7 1.5 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN2CCN(C)CC2)C32CC2)n1 nan
CHEMBL3728337 135429 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 9 2 7 1.5 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCN2CCN(C)CC2)C32CC2)n1 nan
89684994 135882 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 515 4 2 4 4.0 CC(C)(C)OC(=O)N1CC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1 nan
CHEMBL3731092 135882 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 515 4 2 4 4.0 CC(C)(C)OC(=O)N1CC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1 nan
162654865 180551 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 433 5 3 4 3.8 Cc1nn(C)cc1NC(=O)C(NC(=O)Nc1ccc(Br)cc1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4754119 180551 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 433 5 3 4 3.8 Cc1nn(C)cc1NC(=O)C(NC(=O)Nc1ccc(Br)cc1)C1CCCC1 10.1016/j.ejmech.2021.113194
310357 139118 16 None - 1 Human 5.3 pEC50 = 5.3 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 340 3 2 4 3.3 Cc1c(NC(=O)Nc2ccc(F)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL378707 139118 16 None - 1 Human 5.3 pEC50 = 5.3 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 340 3 2 4 3.3 Cc1c(NC(=O)Nc2ccc(F)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL5078594 214545 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR2 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assayAgonist activity at human FPR2 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assay
ChEMBL None None None Cc1nn(C)cc1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O 10.1016/j.ejmech.2021.113805
87422158 135785 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 7 2 6 2.4 CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3730506 135785 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 7 2 6 2.4 CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67495439 135809 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 8 2 3 3.5 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1 nan
CHEMBL3730671 135809 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 485 8 2 3 3.5 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCN1CCCC1)C21CC1 nan
1367800 78088 27 None - 1 Human 6.3 pEC50 = 6.3 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 356 3 2 4 3.8 Cc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL210298 78088 27 None - 1 Human 6.3 pEC50 = 6.3 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 356 3 2 4 3.8 Cc1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
122181323 121838 0 None 2 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590074 121838 0 None 2 2 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
122181232 121821 0 None -8 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589946 121821 0 None -8 2 Mouse 5.3 pEC50 = 5.3 Functional
Agonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at FPR2 in BALB/c mouse assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
67496566 136273 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 8 2 5 3.6 O=C(Nc1ccc2ncoc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728646 136273 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 8 2 5 3.6 O=C(Nc1ccc2ncoc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733950 136273 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 8 2 5 3.6 O=C(Nc1ccc2ncoc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
11024 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at human FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
11024 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
122583088 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
CHEMBL4784510 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
67496890 135933 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 418 6 2 3 3.0 COCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731396 135933 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 418 6 2 3 3.0 COCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495869 136289 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.2 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(F)CN1CCCC1)C21CC1 nan
CHEMBL3732090 136289 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.2 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(F)CN1CCCC1)C21CC1 nan
CHEMBL3733985 136289 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 8 2 3 4.2 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCC(F)CN1CCCC1)C21CC1 nan
127035056 135921 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 477 8 2 3 4.7 O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731308 135921 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 477 8 2 3 4.7 O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496357 136169 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 518 7 3 3 4.8 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1 nan
CHEMBL3732803 136169 0 None - 1 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 518 7 3 3 4.8 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCc1nc3ccccc3[nH]1)C21CC1 nan
87421957 135858 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 464 5 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 nan
CHEMBL3730960 135858 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 464 5 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 nan
67496595 135626 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 6 2 3 3.8 CN1CCCC1CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729542 135626 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 6 2 3 3.8 CN1CCCC1CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422137 136002 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 432 6 3 4 1.6 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)nc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731817 136002 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 432 6 3 4 1.6 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)nc2)[C@@H]2C=C[C@H]1C21CC1 nan
93095549 121708 7 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 385 5 2 2 4.1 O=C(Nc1ccc(Cl)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1 10.1016/j.bmc.2015.03.062
CHEMBL3588927 121708 7 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 385 5 2 2 4.1 O=C(Nc1ccc(Cl)cc1)N[C@@H](Cc1ccccc1)C(=O)N1CCCCC1 10.1016/j.bmc.2015.03.062
67495885 135480 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 6 2 2 4.1 CCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728603 135480 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 6 2 2 4.1 CCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
57377976 151076 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 412 6 2 9 2.6 CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3ccc(F)cc3)n2)n1 nan
CHEMBL3959136 151076 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 412 6 2 9 2.6 CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3ccc(F)cc3)n2)n1 nan
146035588 170872 2 None 5 2 Human 7.3 pEC50 = 7.3 Functional
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4454594 170872 2 None 5 2 Human 7.3 pEC50 = 7.3 Functional
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL5085666 214956 5 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccc(F)cc2)C1=O 10.1016/j.ejmech.2021.113805
24776344 94224 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 374 3 1 4 4.0 COc1ccc2[nH]c(C(=O)N3CCC(n4cnc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
CHEMBL250143 94224 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 374 3 1 4 4.0 COc1ccc2[nH]c(C(=O)N3CCC(n4cnc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
44413526 138341 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 405 4 2 7 3.6 CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(C3=NCCS3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
CHEMBL377163 138341 0 None - 1 Human 5.3 pEC50 = 5.3 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 405 4 2 7 3.6 CSc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(C3=NCCS3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
67495101 136266 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 9 2 3 3.3 O=C(NCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732392 136266 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 9 2 3 3.3 O=C(NCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733943 136266 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 9 2 3 3.3 O=C(NCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495555 135903 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 384 7 3 4 2.1 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(=O)O)C32CC2)cc1 nan
CHEMBL3731200 135903 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 384 7 3 4 2.1 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCC(=O)O)C32CC2)cc1 nan
87422285 135397 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 554 9 3 6 4.7 CC(C)(C)OC(=O)NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3728159 135397 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 554 9 3 6 4.7 CC(C)(C)OC(=O)NCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
67495416 135816 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 463 8 3 3 2.9 NCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730697 135816 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 463 8 3 3 2.9 NCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1 nan
67495407 135948 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 417 10 2 5 1.5 COC(=O)CCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731492 135948 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 417 10 2 5 1.5 COC(=O)CCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
146035589 173705 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4536334 173705 0 None 1 2 Human 7.3 pEC50 = 7.3 Functional
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
57378199 148150 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 448 7 2 9 3.6 Cc1cccc(-c2oc(C3CC3)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
CHEMBL3935685 148150 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 448 7 2 9 3.6 Cc1cccc(-c2oc(C3CC3)nc2C(=O)Nc2cnn(Cc3nc(C(C)(C)O)co3)n2)c1 nan
168283383 190820 0 None 3 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184396 190820 0 None 3 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
67495545 135796 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 7 2 2 5.1 O=C(CCc1ccc(F)cc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730596 135796 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 7 2 2 5.1 O=C(CCc1ccc(F)cc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
146648736 191727 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 470 6 2 7 3.6 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(OC(F)(F)F)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5197524 191727 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 470 6 2 7 3.6 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(OC(F)(F)F)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
87421961 135311 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 494 10 2 5 3.9 CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727646 135311 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 494 10 2 5 3.9 CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
67496833 136069 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 6 3 3 3.0 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 nan
CHEMBL3732223 136069 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 471 6 3 3 3.0 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 nan
44413507 138306 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 393 3 2 6 3.6 CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(C2=NCCS2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL377130 138306 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 393 3 2 6 3.6 CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(C2=NCCS2)n1C 10.1016/j.bmcl.2006.04.068
162658091 181028 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 423 6 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)NCC1CCCO1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4759517 181028 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 423 6 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)NCC1CCCO1)C1CCCC1 10.1016/j.ejmech.2021.113194
44232924 195300 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL551590 195300 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 7 1 5 3.9 COc1cccc(Cc2cc(C)nn(CCC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
67495592 136221 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 477 9 3 3 3.3 NCCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3733163 136221 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 477 9 3 3 3.3 NCCCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL5087410 215073 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1 10.1016/j.ejmech.2021.113805
71698528 90641 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 3.6 CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391255 90641 0 None -1 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 503 7 1 5 3.6 CCc1cc(Cc2cccc(OC)c2)c(=O)n(CC(=O)Nc2ccc(I)cc2)n1 10.1016/j.ejmech.2013.03.066
67495725 135312 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 571 6 2 4 5.4 CC(C)(C)OC(=O)N1CCCC(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1 nan
CHEMBL3727655 135312 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 571 6 2 4 5.4 CC(C)(C)OC(=O)N1CCCC(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)C1 nan
67495540 136244 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 425 9 2 4 3.0 Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1 nan
CHEMBL3733305 136244 0 None - 1 Human 6.3 pEC50 = 6.3 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 425 9 2 4 3.0 Cc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1 nan
168292800 192038 0 None 3 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5202577 192038 0 None 3 2 Human 5.3 pEC50 = 5.3 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
87422038 135753 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 424 4 3 5 2.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CNC1)C21CC1 nan
CHEMBL3730324 135753 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 424 4 3 5 2.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CNC1)C21CC1 nan
127036326 136168 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 478 8 2 5 4.4 Cc1nc2ccc(NC(=O)[C@@H]3[C@@H]4C=C[C@H]([C@H]3C(=O)NCCCCN3CCCC3)C43CC3)cc2s1 nan
CHEMBL3732799 136168 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 478 8 2 5 4.4 Cc1nc2ccc(NC(=O)[C@@H]3[C@@H]4C=C[C@H]([C@H]3C(=O)NCCCCN3CCCC3)C43CC3)cc2s1 nan
67494937 135536 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 412 8 2 5 2.7 Cc1coc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
CHEMBL3728965 135536 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 412 8 2 5 2.7 Cc1coc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
89684990 136114 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 7 2 3 4.8 CC(C)CCN1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3732502 136114 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 7 2 3 4.8 CC(C)CCN1CCC(NC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
2211856 77737 11 None - 1 Human 5.2 pEC50 = 5.2 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 366 3 2 6 2.9 Cc1c(NC(=O)Nc2ccc3c(c2)OCO3)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL209102 77737 11 None - 1 Human 5.2 pEC50 = 5.2 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 366 3 2 6 2.9 Cc1c(NC(=O)Nc2ccc3c(c2)OCO3)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
67495300 135833 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 385 7 3 4 1.7 COc1ccc(NC(=O)[C@@H]2[C@@H]3CC[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)cc1 nan
CHEMBL3730815 135833 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 385 7 3 4 1.7 COc1ccc(NC(=O)[C@@H]2[C@@H]3CC[C@H]([C@H]2C(=O)NCCC(N)=O)C32CC2)cc1 nan
67495243 136134 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 493 7 3 3 3.7 NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1 nan
CHEMBL3732601 136134 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 493 7 3 3 3.7 NCc1cccc(CNC(=O)[C@H]2[C@H](C(=O)NCc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c1 nan
67495785 135275 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 9 1 4 3.3 COCCN(CCOC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727426 135275 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 9 1 4 3.3 COCCN(CCOC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495572 135345 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 404 5 3 3 2.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCO)C21CC1 nan
CHEMBL3727812 135345 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 404 5 3 3 2.3 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCO)C21CC1 nan
67495383 135500 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 7 2 3 3.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCC(=O)N1CCCC1)C21CC1 nan
CHEMBL3728739 135500 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 7 2 3 3.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCC(=O)N1CCCC1)C21CC1 nan
87422236 135465 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 466 4 2 5 3.1 NCC1CCN(C(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3CC[C@H]2C32CC2)CC1 nan
CHEMBL3728521 135465 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 466 4 2 5 3.1 NCC1CCN(C(=O)[C@H]2[C@H](C(=O)Nc3ncc(Br)s3)[C@@H]3CC[C@H]2C32CC2)CC1 nan
87421986 135628 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 492 8 2 5 3.7 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729552 135628 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 492 8 2 5 3.7 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495518 136101 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 417 5 3 3 1.8 NC(=O)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732419 136101 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 417 5 3 3 1.8 NC(=O)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422206 135280 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 399 4 2 3 2.9 N#CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727442 135280 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 399 4 2 3 2.9 N#CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
122181231 121681 0 None 2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3588871 121681 0 None 2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL5087410 215073 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None CC(C)(C)OC(=O)N1CCC[C@H](N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)C1 10.1016/j.ejmech.2021.113805
67495699 135452 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 427 9 2 3 3.5 O=C(NCC1CCCCC1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728471 135452 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 427 9 2 3 3.5 O=C(NCC1CCCCC1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
162657326 180848 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 423 5 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CCOCC1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4757408 180848 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 423 5 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CCOCC1)C1CCCC1 10.1016/j.ejmech.2021.113194
162672626 183064 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 416 4 3 3 4.2 Cc1ccc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1 10.1016/j.ejmech.2021.113194
CHEMBL4794472 183064 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 416 4 3 3 4.2 Cc1ccc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1 10.1016/j.ejmech.2021.113194
44233645 196162 0 None 5 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
CHEMBL561375 196162 0 None 5 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
44232925 196626 2 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL564392 196626 2 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
44233645 196162 0 None 5 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
CHEMBL561375 196162 0 None 5 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 363 6 1 5 2.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccccc3)c2=O)c1 10.1021/jm900592h
44232925 196626 2 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL564392 196626 2 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 455 6 1 5 4.1 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1021/jm900592h
1131797 121882 16 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 355 6 2 5 3.5 COc1ccc2[nH]c(SCC(=O)Nc3ccc(C(C)=O)cc3)nc2c1 10.1016/j.bmc.2015.03.062
CHEMBL3590210 121882 16 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 355 6 2 5 3.5 COc1ccc2[nH]c(SCC(=O)Nc3ccc(C(C)=O)cc3)nc2c1 10.1016/j.bmc.2015.03.062
67495159 136276 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 483 8 2 6 3.3 O=C(Nc1nnc(C(F)(F)F)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730534 136276 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 483 8 2 6 3.3 O=C(Nc1nnc(C(F)(F)F)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733953 136276 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 483 8 2 6 3.3 O=C(Nc1nnc(C(F)(F)F)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
162652531 180384 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 402 4 3 3 3.9 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccccn2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4752145 180384 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 402 4 3 3 3.9 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccccn2)CCCC1 10.1016/j.ejmech.2021.113194
87422208 135636 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 7 2 5 2.7 CN(C)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729600 135636 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 7 2 5 2.7 CN(C)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
87422124 135807 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 5 3 5 3.6 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)N[C@H]1CC[C@@H](CO)CC1)C21CC1 nan
CHEMBL3730665 135807 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 5 3 5 3.6 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)N[C@H]1CC[C@@H](CO)CC1)C21CC1 nan
67495691 135910 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 498 6 2 2 5.2 O=C(Cc1ccccc1Cl)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731223 135910 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 498 6 2 2 5.2 O=C(Cc1ccccc1Cl)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495560 136177 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 6 2 3 4.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCc1ccccn1)C21CC1 nan
CHEMBL3732870 136177 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 6 2 3 4.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCc1ccccn1)C21CC1 nan
162656471 180812 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 395 5 3 3 2.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1COC1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4757032 180812 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 395 5 3 3 2.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1COC1)C1CCCC1 10.1016/j.ejmech.2021.113194
122181323 121838 0 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590074 121838 0 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
168281748 190861 0 None 6 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184913 190861 0 None 6 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
67496239 135800 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 400 4 2 2 3.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CC1)C21CC1 nan
CHEMBL3730609 135800 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 400 4 2 2 3.5 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NC1CC1)C21CC1 nan
67495876 136135 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 545 7 3 4 4.9 CC(C)(CNC(=O)OC(C)(C)C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732602 136135 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 545 7 3 4 4.9 CC(C)(CNC(=O)OC(C)(C)C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
145952485 162829 0 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4172968 162829 0 None 2 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 483 9 3 5 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc([N+](=O)[O-])cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
71698972 90649 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 401 5 1 5 3.1 Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL2391285 90649 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 401 5 1 5 3.1 Cc1cc(Cc2ccoc2)c(=O)n(CC(=O)Nc2ccc(Br)cc2)n1 10.1016/j.ejmech.2013.03.066
CHEMBL5087710 215091 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None CC(C)(C)OC(=O)N1CCC(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)CC1 10.1016/j.ejmech.2021.113805
67496888 136059 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 10 2 6 2.8 CC(=O)c1cnc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
CHEMBL3732163 136059 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 10 2 6 2.8 CC(=O)c1cnc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
67496605 136283 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 453 10 2 3 3.3 O=C(NCCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732978 136283 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 453 10 2 3 3.3 O=C(NCCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733979 136283 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 453 10 2 3 3.3 O=C(NCCc1ccc(F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
122181231 121681 0 None 2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3588871 121681 0 None 2 3 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
145963525 162299 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4164673 162299 0 None -2 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
67496231 135484 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 8 2 6 1.5 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCN(C)C)C32CC2)n1 nan
CHEMBL3728633 135484 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 8 2 6 1.5 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCN(C)C)C32CC2)n1 nan
145958696 162130 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4161946 162130 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 482 9 4 3 4.8 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2017.09.023
122181233 121822 0 None -1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589947 121822 0 None -1 2 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 543 9 4 4 5.5 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccnc(F)c3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
145978177 163037 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 452 8 4 2 4.7 O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4176353 163037 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 452 8 4 2 4.7 O=C(Nc1ccccc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
67495182 135525 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 4 3.6 CC(=O)c1cccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1 nan
CHEMBL3728870 135525 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 4 3.6 CC(=O)c1cccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1 nan
87422170 136275 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 8 2 5 3.2 Cc1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
CHEMBL3730618 136275 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 8 2 5 3.2 Cc1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
CHEMBL3733952 136275 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 428 8 2 5 3.2 Cc1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
87422375 136066 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 420 6 2 2 3.0 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1 nan
CHEMBL3732201 136066 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 420 6 2 2 3.0 O=C(NCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCF)C21CC1 nan
67496832 136269 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 438 9 2 5 2.8 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1 nan
CHEMBL3728237 136269 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 438 9 2 5 2.8 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1 nan
CHEMBL3733946 136269 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 438 9 2 5 2.8 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cn1 nan
162663800 181892 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 402 6 3 3 3.8 O=C(Nc1ccc(Br)cc1)N[C@@H](CC1CC1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
CHEMBL4779558 181892 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 402 6 3 3 3.8 O=C(Nc1ccc(Br)cc1)N[C@@H](CC1CC1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
168297721 192427 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 343 3 2 3 2.8 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3ccccc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5208504 192427 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 343 3 2 3 2.8 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2c2nc3ccccc3[nH]2)c(F)c1 10.1021/acsmedchemlett.2c00079
44233644 196067 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL560780 196067 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 489 6 1 5 3.4 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(I)cc3)c2=O)c1 10.1021/jm900592h
87422214 135468 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 467 4 3 5 3.3 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCC(O)CC1)C21CC1 nan
CHEMBL3728538 135468 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 467 4 3 5 3.3 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCC(O)CC1)C21CC1 nan
24776346 94249 5 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 402 4 1 4 4.6 CCc1nc2ccccc2n1C1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)CC1 10.1016/j.bmcl.2007.09.043
CHEMBL250347 94249 5 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 402 4 1 4 4.6 CCc1nc2ccccc2n1C1CCN(C(=O)c2cc3cc(OC)ccc3[nH]2)CC1 10.1016/j.bmcl.2007.09.043
168272319 190551 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5180261 190551 0 None -1 2 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
67495180 136227 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(F)cc1Br)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733198 136227 0 None - 1 Human 5.2 pEC50 = 5.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(F)cc1Br)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
127034681 136031 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 6 2 2 5.0 O=C(/C=C/c1ccccc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732009 136031 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 476 6 2 2 5.0 O=C(/C=C/c1ccccc1)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
122181408 121878 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 501 7 2 4 4.0 CCOC(=O)C1CCCN(C(=O)[C@H](Cc2ccccc2)NC(=O)Nc2ccc(Br)cc2)C1 10.1016/j.bmc.2015.03.062
CHEMBL3590206 121878 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 501 7 2 4 4.0 CCOC(=O)C1CCCN(C(=O)[C@H](Cc2ccccc2)NC(=O)Nc2ccc(Br)cc2)C1 10.1016/j.bmc.2015.03.062
67496055 135339 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 468 7 2 4 3.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1cccn1)C21CC1 nan
CHEMBL3727798 135339 0 None - 1 Human 8.2 pEC50 = 8.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 468 7 2 4 3.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1cccn1)C21CC1 nan
87421975 136219 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 466 5 3 5 3.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 nan
CHEMBL3733130 136219 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 466 5 3 5 3.0 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCNCC1)C21CC1 nan
67496570 136260 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 3 3 2.6 NC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729822 136260 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 3 3 2.6 NC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3733937 136260 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 3 3 2.6 NC(=O)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495789 135340 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 6 3 3 4.0 NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
CHEMBL3727801 135340 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 6 3 3 4.0 NCc1ccc(CNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)cc1 nan
67495768 135589 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 9 1 3 4.4 CCN(CC)CCN(CC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729293 135589 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 9 1 3 4.4 CCN(CC)CCN(CC)C(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
57336781 145608 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 420 6 2 9 2.8 Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C4(O)CC4)co3)n2)c1 nan
CHEMBL3915698 145608 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 420 6 2 9 2.8 Cc1cccc(-c2oc(C)nc2C(=O)Nc2cnn(Cc3nc(C4(O)CC4)co3)n2)c1 nan
87421981 135272 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 8 2 4 3.5 O=C(Nc1ccc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727408 135272 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 442 8 2 4 3.5 O=C(Nc1ccc(Cl)nc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
127036710 136044 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 7 3 4 1.5 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)nc2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3732086 136044 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 448 7 3 4 1.5 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)nc2)[C@@H]2CC[C@H]1C21CC1 nan
87422198 136270 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 8 2 5 3.0 O=C(Nc1cnc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730451 136270 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 8 2 5 3.0 O=C(Nc1cnc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733947 136270 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 8 2 5 3.0 O=C(Nc1cnc(Br)cn1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
162649751 180065 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 417 5 3 4 3.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnn1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4748148 180065 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 417 5 3 4 3.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnn1)C1CCCC1 10.1016/j.ejmech.2021.113194
67495050 135671 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 5 2 4 5.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccnn1-c1ccccc1)C21CC1 nan
CHEMBL3729807 135671 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 5 2 4 5.0 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)Nc1ccnn1-c1ccccc1)C21CC1 nan
CHEMBL5085818 214968 0 None - 1 Human 6.2 pEC50 = 6.2 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(Cc3ccccc3)C2)C1=O 10.1016/j.ejmech.2021.113805
67495005 135431 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 427 8 2 3 3.5 CC1CCC(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)CC1 nan
CHEMBL3728342 135431 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 427 8 2 3 3.5 CC1CCC(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)CC1 nan
67495777 135456 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 7 3 3 2.2 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3728499 135456 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 7 3 3 2.2 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2F)[C@@H]2CC[C@H]1C21CC1 nan
67495450 136171 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 6 2 4 4.6 Cc1nc(CC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c(C)s1 nan
CHEMBL3732813 136171 0 None - 1 Human 7.2 pEC50 = 7.2 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 499 6 2 4 4.6 Cc1nc(CC(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)c(C)s1 nan
162671881 182820 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 432 5 3 4 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCOCC1 10.1016/j.ejmech.2021.113194
CHEMBL4791407 182820 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 432 5 3 4 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCOCC1 10.1016/j.ejmech.2021.113194
67495882 135627 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 6 2 2 4.1 CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729543 135627 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 416 6 2 2 4.1 CCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495372 136037 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 432 7 2 3 3.4 COCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732041 136037 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 432 7 2 3 3.4 COCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
71698529 90642 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 469 7 1 5 4.4 COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391256 90642 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 469 7 1 5 4.4 COc1cccc(Cc2cc(C(C)C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
168278240 191077 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187767 191077 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
67495757 136268 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 11 2 4 3.9 CC(C)Oc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3728716 136268 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 11 2 4 3.9 CC(C)Oc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3733945 136268 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 11 2 4 3.9 CC(C)Oc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
67495677 135442 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 506 9 2 5 3.3 O=C(NCc1nc(Br)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728393 135442 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 506 9 2 5 3.3 O=C(NCc1nc(Br)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495654 136100 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 444 8 2 2 4.9 CCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732418 136100 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 444 8 2 2 4.9 CCCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
53552475 181264 4 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 348 4 3 3 2.6 O=C(CNC(=O)Nc1ccc(Br)cc1)Nc1cccnc1 10.1016/j.ejmech.2021.113194
CHEMBL4762222 181264 4 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 348 4 3 3 2.6 O=C(CNC(=O)Nc1ccc(Br)cc1)Nc1cccnc1 10.1016/j.ejmech.2021.113194
145963525 162299 0 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4164673 162299 0 None -2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 459 9 3 5 3.6 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1cccnc1)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
145956276 162652 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL4170201 162652 0 None -1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric methodAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization measured every 5 secs for 240 secs by Fluo-4-AM dye based fluorometric method
ChEMBL 520 9 3 4 4.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(F)c(Cl)c3)CC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL5087710 215091 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None CC(C)(C)OC(=O)N1CCC(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)CC1 10.1016/j.ejmech.2021.113805
122181320 121836 0 None 5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590071 121836 0 None 5 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 525 9 4 4 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3cccnc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
122181409 121884 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 386 6 3 6 3.5 COC(=O)Nc1cccc(NC(=O)CSc2nc3cc(OC)ccc3[nH]2)c1 10.1016/j.bmc.2015.03.062
CHEMBL3590212 121884 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 386 6 3 6 3.5 COC(=O)Nc1cccc(NC(=O)CSc2nc3cc(OC)ccc3[nH]2)c1 10.1016/j.bmc.2015.03.062
67495713 136089 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 435 10 2 3 3.2 O=C(NCCc1ccccc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732365 136089 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 435 10 2 3 3.2 O=C(NCCc1ccccc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495219 135985 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 508 8 2 3 4.6 COC[C@H](Cc1ccccc1)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3731705 135985 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 508 8 2 3 4.6 COC[C@H](Cc1ccccc1)NC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL5076914 214446 4 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR2 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assayAgonist activity at human FPR2 expressed in HEK293-A cells assessed as ERK phosphorylation level incubated for 5 mins by ELISA assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(c2ccccc2)C1=O 10.1016/j.ejmech.2021.113805
CHEMBL5078594 214545 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL None None None Cc1nn(C)cc1N1CCC(NC(=O)Nc2ccc(Br)cc2)C1=O 10.1016/j.ejmech.2021.113805
67495741 135645 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 8 3 3 3.9 O=C(Nc1ccc2[nH]ccc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729642 135645 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 446 8 3 3 3.9 O=C(Nc1ccc2[nH]ccc2c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496174 135738 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(F)c(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730234 135738 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 517 9 2 3 4.0 O=C(NCc1ccc(F)c(Br)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495408 135295 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 415 11 2 4 2.3 CC(=O)CCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727528 135295 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 415 11 2 4 2.3 CC(=O)CCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495972 135949 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 9 2 3 3.5 O=C(NCc1cc(F)cc(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731494 135949 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 9 2 3 3.5 O=C(NCc1cc(F)cc(F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3407845 211612 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Induction of calcium release in human FPR2 receptor-expressed HEK cell by cytosolic-free calcium assayInduction of calcium release in human FPR2 receptor-expressed HEK cell by cytosolic-free calcium assay
ChEMBL None None None None 10.1021/jm501018q
67495853 135270 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 7 3 3 2.4 NCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3727378 135270 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 431 7 3 3 2.4 NCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
145951632 162850 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization
ChEMBL 497 9 4 4 4.7 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
CHEMBL4173297 162850 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilizationAgonist activity at human FPR2 expressed in human HL60 cells assessed as induction of calcium mobilization
ChEMBL 497 9 4 4 4.7 O=C(Nc1ccc([N+](=O)[O-])cc1)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC1(c2ccccc2)CC1 10.1016/j.ejmech.2017.09.023
87422282 135900 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 8 2 5 4.2 O=C(Nc1nc2ccc(F)cc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3731186 135900 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 8 2 5 4.2 O=C(Nc1nc2ccc(F)cc2s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495903 136285 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 10 2 5 2.9 O=C(NCCc1ccc2c(c1)OCO2)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729493 136285 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 10 2 5 2.9 O=C(NCCc1ccc2c(c1)OCO2)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733980 136285 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 10 2 5 2.9 O=C(NCCc1ccc2c(c1)OCO2)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495914 135384 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 7 2 4 4.1 CCn1nc(C)cc1CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728092 135384 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 7 2 4 4.1 CCn1nc(C)cc1CCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67494992 135806 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 6 3 3 3.9 Cc1nc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)Nc2ccc(Br)cc2)C32CC2)[nH]c1C nan
CHEMBL3730664 135806 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 482 6 3 3 3.9 Cc1nc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)Nc2ccc(Br)cc2)C32CC2)[nH]c1C nan
1292869 139092 10 None - 1 Human 6.1 pEC50 = 6.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 350 4 2 4 3.7 CCc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
CHEMBL378679 139092 10 None - 1 Human 6.1 pEC50 = 6.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 350 4 2 4 3.7 CCc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1 10.1016/j.bmcl.2006.04.068
71698527 90640 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 6 1 5 3.2 COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
CHEMBL2391254 90640 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 427 6 1 5 3.2 COc1cccc(Cc2ccnn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2013.03.066
67495765 135351 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 427 9 2 6 1.8 Cc1nonc1CNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727847 135351 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 427 9 2 6 1.8 Cc1nonc1CNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
71699142 90677 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 442 6 2 6 3.7 COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
CHEMBL2391449 90677 0 None 1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilizationAgonist activity at FPR2 (unknown origin) transfected in human HL60 cells assessed as induction of Ca2+ mobilization
ChEMBL 442 6 2 6 3.7 COc1ccc(Nc2cc(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2013.03.066
87422142 135616 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 456 9 2 6 3.1 CC(=O)c1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
CHEMBL3729495 135616 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 456 9 2 6 3.1 CC(=O)c1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
67495073 136187 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 401 11 2 3 3.1 CCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732930 136187 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 401 11 2 3 3.1 CCCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496040 136045 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 9 2 3 4.3 O=C(NCc1cccc(C(F)(F)F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732087 136045 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 9 2 3 4.3 O=C(NCc1cccc(C(F)(F)F)c1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495981 135632 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 3 3.7 Cc1cc(C)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1 nan
CHEMBL3729585 135632 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 9 2 3 3.7 Cc1cc(C)cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1 nan
CHEMBL5093348 215401 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None O=C(Nc1ccc(Br)cc1)NC1CCN(C2CCN(c3ncccn3)CC2)C1=O 10.1016/j.ejmech.2021.113805
57377977 154019 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 394 6 2 9 2.4 CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3ccccc3)n2)n1 nan
CHEMBL3984386 154019 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 394 6 2 9 2.4 CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncoc3-c3ccccc3)n2)n1 nan
87422343 135840 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 438 6 3 5 1.7 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730856 135840 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 438 6 3 5 1.7 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
67495034 135864 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 9 2 3 4.1 CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730991 135864 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 9 2 3 4.1 CN(C)CCCCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67496009 135322 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 484 6 3 3 4.1 Cc1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3CC[C@H]2C32CC2)[nH]c1C nan
CHEMBL3727697 135322 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 484 6 3 3 4.1 Cc1nc(CCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3CC[C@H]2C32CC2)[nH]c1C nan
87422284 135568 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 5 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCN1)C21CC1 nan
CHEMBL3729189 135568 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 5 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCC1CCCN1)C21CC1 nan
87422074 135917 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 438 4 3 5 2.4 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCNC1)C21CC1 nan
CHEMBL3731273 135917 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 438 4 3 5 2.4 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCNC1)C21CC1 nan
44413497 78090 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 435 4 2 5 5.1 CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL210303 78090 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 435 4 2 5 5.1 CC(C)c1c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n(-c2cnc3ccccc3c2)n1C 10.1016/j.bmcl.2006.04.068
67496490 135535 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 7 2 3 3.2 CN(C)C(=O)CCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728947 135535 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 7 2 3 3.2 CN(C)C(=O)CCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422056 135779 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 441 7 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCO)C21CC1 nan
CHEMBL3730490 135779 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 441 7 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCCO)C21CC1 nan
67496609 136030 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 549 7 2 4 4.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC(c1ccccc1)N1CCOCC1)C21CC1 nan
CHEMBL3732008 136030 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 549 7 2 4 4.4 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC(c1ccccc1)N1CCOCC1)C21CC1 nan
67495637 136099 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 9 2 3 4.1 CCN(CC)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3732416 136099 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 9 2 3 4.1 CCN(CC)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
162660629 181243 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 417 5 3 4 3.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cncnc1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4761978 181243 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 417 5 3 4 3.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cncnc1)C1CCCC1 10.1016/j.ejmech.2021.113194
4776370 121885 9 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 373 7 2 5 4.4 CCOc1ccc2[nH]c(SCC(=O)Nc3ccccc3SC)nc2c1 10.1016/j.bmc.2015.03.062
CHEMBL3590213 121885 9 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 373 7 2 5 4.4 CCOc1ccc2[nH]c(SCC(=O)Nc3ccccc3SC)nc2c1 10.1016/j.bmc.2015.03.062
67495656 136040 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 415 11 2 3 3.4 CCC(CC)CNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732051 136040 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 415 11 2 3 3.4 CCC(CC)CNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
44413548 79763 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 382 4 2 4 4.4 Cc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3ccccc3)c2=O)cc1F 10.1016/j.bmcl.2006.04.068
CHEMBL211957 79763 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 382 4 2 4 4.4 Cc1ccc(NC(=O)Nc2c(C(C)C)n(C)n(-c3ccccc3)c2=O)cc1F 10.1016/j.bmcl.2006.04.068
24776355 94137 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 436 3 1 3 4.9 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
CHEMBL249537 94137 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 436 3 1 3 4.9 CCc1nc2ccccc2n1[C@@H]1CCN(C(=O)c2cc3cc(Br)ccc3[nH]2)C1 10.1016/j.bmcl.2007.09.043
67495598 136201 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 531 6 2 4 5.5 Cc1onc(-c2ccccc2)c1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3733039 136201 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 531 6 2 4 5.5 Cc1onc(-c2ccccc2)c1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495242 135735 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 402 4 2 2 3.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CC1)C21CC1 nan
CHEMBL3730215 135735 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 402 4 2 2 3.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CC1)C21CC1 nan
67495596 135743 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 8 3 6 0.9 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCN2CCNC2=O)C32CC2)n1 nan
CHEMBL3730255 135743 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 457 8 3 6 0.9 CC(=O)c1csc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCN2CCNC2=O)C32CC2)n1 nan
87422303 136032 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 425 5 2 4 3.7 CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
CHEMBL3732014 136032 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 425 5 2 4 3.7 CC(C)CNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2CC[C@H]1C21CC1 nan
67495351 136271 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 8 2 3 4.5 O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729485 136271 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 8 2 3 4.5 O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733948 136271 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 475 8 2 3 4.5 O=C(Nc1ccc(C(F)(F)F)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
57378195 153159 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 428 6 2 9 3.1 CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncsc3-c3cccc(F)c3)n2)n1 nan
CHEMBL3977012 153159 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.Intracellular Calcium Assay: Cells expressing recombinant human ALX receptor and the G-protein Gα16 (HEK293-hALXR-Gα16) were grown to 80% confluency in Growing Medium (GM). Cells were detached from culture dishes with a cell dissociation buffer (Invitrogen, 13151-014), and collected by centrifugation at 1,000 rpm at rt for 5 min in Assay Buffer (AB) (equal parts of Hank's BSS (Gibco, 14065-049) and DMEM without Phenol Red (Gibco, 11880-028)). After 60 min incubation at 37° C. under 5% CO2 in AB supplemented with 1 μM Fluo-4 (AM) (Invitrogen, F14202) and 20 mM HEPES (Gibco, 15630-056), the cells were washed and resuspended in AB. They were then seeded onto 384-well FLIPR assay plates (Greiner, 781091) at 50,000 cells in 70 μl per well and sedimented by centrifugation at 1,000 rpm for 1 min. Stock solutions of test compounds were made up at a concentration of 10 mM in DMSO, and serially diluted in AB to concentrations required for activation dose response curves.
ChEMBL 428 6 2 9 3.1 CC(C)(O)c1coc(Cn2ncc(NC(=O)c3ncsc3-c3cccc(F)c3)n2)n1 nan
44236329 195424 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL552396 195424 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
44236329 195424 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL552396 195424 0 None -1 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 381 6 1 5 2.9 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(F)cc3)c2=O)c1 10.1021/jm900592h
67495302 136236 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 10 2 3 3.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733261 136236 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 469 10 2 3 3.8 O=C(NCCc1ccc(Cl)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
44413563 79699 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 396 3 2 4 4.6 Cc1ccc(NC(=O)Nc2c(C(C)(C)C)n(C)n(-c3ccccc3)c2=O)cc1F 10.1016/j.bmcl.2006.04.068
CHEMBL211595 79699 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 396 3 2 4 4.6 Cc1ccc(NC(=O)Nc2c(C(C)(C)C)n(C)n(-c3ccccc3)c2=O)cc1F 10.1016/j.bmcl.2006.04.068
24776347 154736 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 430 5 1 4 5.2 COc1ccc2[nH]c(C(=O)N3CCC(n4c(CC(C)C)nc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
CHEMBL400089 154736 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assayAgonist activity at human recombinant FPRL1 expressed in CHO cells assessed as calcium flux by aequorin based bioluminescence assay
ChEMBL 430 5 1 4 5.2 COc1ccc2[nH]c(C(=O)N3CCC(n4c(CC(C)C)nc5ccccc54)CC3)cc2c1 10.1016/j.bmcl.2007.09.043
67495602 135848 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 11 2 5 2.2 O=C(NCCCn1ccnc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730904 135848 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 439 11 2 5 2.2 O=C(NCCCn1ccnc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496142 135297 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 463 10 2 4 3.3 CC(=O)c1cccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1 nan
CHEMBL3727532 135297 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 463 10 2 4 3.3 CC(=O)c1cccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c1 nan
146648729 192088 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 438 5 2 6 3.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3F)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5203364 192088 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assayAgonist activity at human FPR2 overexpressing CHO cells assessed as reduction in intracellular cAMP level incubated for 30 mins by HTRF assay
ChEMBL 438 5 2 6 3.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3F)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
87421997 136054 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 524 9 2 5 5.2 O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732146 136054 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 524 9 2 5 5.2 O=C(Nc1nc(-c2ccc(Cl)cc2)cs1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
87422124 136006 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 5 3 5 3.6 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)N[C@H]1CC[C@H](CO)CC1)C21CC1 nan
CHEMBL3731851 136006 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 5 3 5 3.6 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)N[C@H]1CC[C@H](CO)CC1)C21CC1 nan
122181231 121681 0 None 2 3 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilizationAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.ejmech.2017.09.023
CHEMBL3588871 121681 0 None 2 3 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilizationAgonist activity at FPR2 in human neutrophils assessed as induction of calcium mobilization
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.ejmech.2017.09.023
122181324 121839 0 None 2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 542 9 4 3 6.1 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590075 121839 0 None 2 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 542 9 4 3 6.1 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(F)cc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
67495936 136280 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 11 2 4 3.2 COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3730257 136280 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 11 2 4 3.2 COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3733975 136280 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 465 11 2 4 3.2 COc1ccc(CCNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
67495884 136010 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 5 2 2 4.9 CC1(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1(Cl)Cl nan
CHEMBL3731870 136010 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 496 5 2 2 4.9 CC1(C(=O)NC[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1(Cl)Cl nan
67496028 135655 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 11 2 4 3.7 O=C(NCc1cccc(OC(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3729706 135655 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 11 2 4 3.7 O=C(NCc1cccc(OC(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495883 135579 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 474 8 2 4 3.7 COC(=O)CCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729231 135579 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 474 8 2 4 3.7 COC(=O)CCCC(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
122181232 121821 0 None 8 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589946 121821 0 None 8 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
44233648 195044 0 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL549570 195044 0 None 2 2 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 expressed in human HL60 cells assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 431 6 1 5 3.8 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C(F)(F)F)cc3)c2=O)c1 10.1021/jm900592h
67495784 136281 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 10 2 3 3.9 O=C(NCCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733191 136281 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 10 2 3 3.9 O=C(NCCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3733976 136281 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 10 2 3 3.9 O=C(NCCc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL5084099 214873 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assayAgonist activity at FPRL1 (unknown origin) expressed in CHO-K1 cells assessed as increase in calcium mobilization incubated for 2.5 hrs by cellular based FLIPR assay
ChEMBL None None None CC(C)n1cc(N2CCC(NC(=O)Nc3ccc(Br)cc3)C2=O)cn1 10.1016/j.ejmech.2021.113805
67495285 135387 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 7 3 5 1.3 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2cnc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728104 135387 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 7 3 5 1.3 NC(=O)CCNC(=O)[C@H]1[C@H](C(=O)NCc2cnc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
67495336 135558 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 10 2 5 2.5 COc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)ccn1 nan
CHEMBL3729111 135558 0 None - 1 Human 5.1 pEC50 = 5.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 10 2 5 2.5 COc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)ccn1 nan
162663817 181904 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 419 4 3 4 3.6 Cc1nn(C)cc1NC(=O)C1(NC(=O)Nc2ccc(Br)cc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4779714 181904 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 419 4 3 4 3.6 Cc1nn(C)cc1NC(=O)C1(NC(=O)Nc2ccc(Br)cc2)CCCC1 10.1016/j.ejmech.2021.113194
67495672 136179 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 9 2 3 4.4 CC(NC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1)c1ccc(Br)cc1 nan
CHEMBL3732885 136179 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 513 9 2 3 4.4 CC(NC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1)c1ccc(Br)cc1 nan
67494972 135670 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 460 9 2 3 3.4 CCOCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729806 135670 0 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 460 9 2 3 3.4 CCOCCCNC(=O)[C@H]1[C@H](C(=O)NCc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67494874 135425 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 437 9 2 4 3.5 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3728297 135425 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 437 9 2 4 3.5 COc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
67495717 136073 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 468 7 2 4 3.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1ccnc1)C21CC1 nan
CHEMBL3732253 136073 0 None - 1 Human 8.1 pEC50 = 8.1 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 468 7 2 4 3.6 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCn1ccnc1)C21CC1 nan
87422368 135820 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 6 3 5 1.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1 nan
CHEMBL3730714 135820 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 479 6 3 5 1.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCNC1=O)C21CC1 nan
87422145 136155 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 4 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCCNC1)C21CC1 nan
CHEMBL3732729 136155 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 452 4 3 5 2.8 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NC1CCCNC1)C21CC1 nan
67495459 136095 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1c(F)cc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732403 136095 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 521 8 2 3 4.5 O=C(Nc1c(F)cc(Br)cc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495311 135597 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 500 7 2 4 3.0 CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
CHEMBL3729352 135597 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 500 7 2 4 3.0 CN1CCN(CCCNC(=O)[C@H]2[C@H](C(=O)Nc3ccc(Br)cc3)[C@@H]3C=C[C@H]2C32CC2)CC1 nan
67496035 135969 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 460 5 2 4 2.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1COCCO1)C21CC1 nan
CHEMBL3731632 135969 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 460 5 2 4 2.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCC1COCCO1)C21CC1 nan
67495282 135546 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 2 3 3.3 CN(C)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729034 135546 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 445 7 2 3 3.3 CN(C)CCCNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
67495568 135935 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 432 7 3 3 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCO)C21CC1 nan
CHEMBL3731406 135935 0 None - 1 Human 8.0 pEC50 = 8.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 432 7 3 3 3.1 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCO)C21CC1 nan
1240119 138687 9 None - 1 Human 7.1 pEC50 = 7.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 400 3 2 4 3.9 Cc1c(NC(=O)Nc2ccc(Br)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
CHEMBL377969 138687 9 None - 1 Human 7.1 pEC50 = 7.1 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 400 3 2 4 3.9 Cc1c(NC(=O)Nc2ccc(Br)cc2)c(=O)n(-c2ccccc2)n1C 10.1016/j.bmcl.2006.04.068
727813 19100 11 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 288 5 2 2 3.2 COc1ccc(CCNC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL1289379 19100 11 None - 1 Human 6.1 pEC50 = 6.1 Functional
Agonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assayAgonist activity against human FPR2 expressed in human HL60 cells by Fluo-4AM dye based intracellular Ca2+ mobilization assay
ChEMBL 288 5 2 2 3.2 COc1ccc(CCNC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.bmc.2015.03.062
44236330 194807 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 194807 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assayAgonist activity at FPRL1 in human neutrophiles assessed as induction of intracellular calcium flux by FLIPR3 calcium assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
44236330 194807 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL539401 194807 0 None 1 2 Human 6.1 pEC50 = 6.1 Functional
Agonist activity at FPRL1 in human neutrophiles by chemotaxis assayAgonist activity at FPRL1 in human neutrophiles by chemotaxis assay
ChEMBL 377 6 1 5 3.1 COc1cccc(Cc2cc(C)nn(CC(=O)Nc3ccc(C)cc3)c2=O)c1 10.1021/jm900592h
CHEMBL3407845 211612 0 None -1 2 Mouse 5.1 pEC50 = 5.1 Functional
Induction of calcium release in mouse FPR2 receptor-expressed HEK cell by cytosolic-free calcium assayInduction of calcium release in mouse FPR2 receptor-expressed HEK cell by cytosolic-free calcium assay
ChEMBL None None None None 10.1021/jm501018q
67495189 136278 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 11 2 5 3.1 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1OC nan
CHEMBL3733201 136278 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 11 2 5 3.1 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1OC nan
CHEMBL3733973 136278 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 481 11 2 5 3.1 COc1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1OC nan
67496363 135513 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 9 2 3 4.3 O=C(NCc1cc(F)cc(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728809 135513 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 9 2 3 4.3 O=C(NCc1cc(F)cc(C(F)(F)F)c1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496175 136261 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1cc(F)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1 nan
CHEMBL3728165 136261 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1cc(F)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1 nan
CHEMBL3733938 136261 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 487 10 2 4 3.4 COc1cc(F)c(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)c(F)c1 nan
67495803 135400 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 8 2 6 3.0 O=C(Nc1cccc2nonc12)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728174 135400 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 449 8 2 6 3.0 O=C(Nc1cccc2nonc12)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496010 135433 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 10 2 6 2.3 CC(=O)c1ncc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1 nan
CHEMBL3728344 135433 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 454 10 2 6 2.3 CC(=O)c1ncc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)o1 nan
122181232 121821 0 None 8 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3589946 121821 0 None 8 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in absence of probenecid
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
67496034 135830 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 468 11 2 5 3.3 CC(C)Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1 nan
CHEMBL3730804 135830 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 468 11 2 5 3.3 CC(C)Cc1cc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)no1 nan
67495569 135758 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 429 12 2 4 2.7 CC(=O)CCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730358 135758 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 429 12 2 4 2.7 CC(=O)CCCCNC(=O)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495825 136102 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 422 8 2 4 3.1 Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)nc1 nan
CHEMBL3732432 136102 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 422 8 2 4 3.1 Cc1ccc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)nc1 nan
24776341 3215 39 None -25 4 Human 7.0 pEC50 = 7.0 Functional
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
5831 3215 39 None -25 4 Human 7.0 pEC50 = 7.0 Functional
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
CHEMBL379761 3215 39 None -25 4 Human 7.0 pEC50 = 7.0 Functional
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
122181231 121681 0 None 2 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3588871 121681 0 None 2 3 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assayAgonist activity at human FPR2 transfected in human HL60 cells assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay
ChEMBL 555 10 4 5 5.3 COc1ccc(NC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccc(OC)cn3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
89685010 135472 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 5 2 4 4.7 CC(C)(C)OC(=O)N1CCCC1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3728558 135472 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 543 5 2 4 4.7 CC(C)(C)OC(=O)N1CCCC1CNC(=O)[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422207 135706 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 427 6 3 5 2.4 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCO)C21CC1 nan
CHEMBL3730036 135706 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 427 6 3 5 2.4 O=C(Nc1ncc(Br)s1)[C@@H]1[C@@H]2CC[C@H]([C@H]1C(=O)NCCCO)C21CC1 nan
67495863 135861 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 5 2 4 4.3 Cc1nn(C)c(Cl)c1C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730978 135861 0 None - 1 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 502 5 2 4 4.3 Cc1nn(C)c(Cl)c1C(=O)NC[C@H]1[C@H](C(=O)Nc2ccc(Br)cc2)[C@@H]2C=C[C@H]1C21CC1 nan
87422055 135572 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 8 2 5 4.2 CC(C)(C)c1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
CHEMBL3729199 135572 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 8 2 5 4.2 CC(C)(C)c1csc(NC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)n1 nan
162655466 180770 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 388 5 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CC1 10.1016/j.ejmech.2021.113194
CHEMBL4756434 180770 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assayAgonist activity at FPR2 (unknown origin) assessed as increase in calcium mobilization by cellular based FLIPR assay
ChEMBL 388 5 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CC1 10.1016/j.ejmech.2021.113194
67495729 135673 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 6 2 4 2.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCOCC1)C21CC1 nan
CHEMBL3729813 135673 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 473 6 2 4 2.7 O=C(Nc1ccc(Br)cc1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCN1CCOCC1)C21CC1 nan
67495852 135805 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 472 12 2 6 3.0 CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)NCc2nc(C(C)=O)cs2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3730658 135805 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 472 12 2 6 3.0 CCN(CC)CCCCNC(=O)[C@H]1[C@H](C(=O)NCc2nc(C(C)=O)cs2)[C@@H]2C=C[C@H]1C21CC1 nan
122181319 121835 0 None 7 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 524 9 4 3 5.9 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
CHEMBL3590070 121835 0 None 7 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecidAgonist activity at FPR2 in human PMN assessed as stimulation of Ca2+ influx measured every 5 secs for 240 secs by FLIPR assay in presence of probenecid
ChEMBL 524 9 4 3 5.9 COc1ccc(NC(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCC2(c3ccccc3)CCCCC2)cc1 10.1016/j.bmc.2014.12.007
67495601 135430 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 10 2 3 4.5 O=C(NCCc1ccc(Cl)cc1Cl)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3728341 135430 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 503 10 2 3 4.5 O=C(NCCc1ccc(Cl)cc1Cl)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495987 136197 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 463 10 2 4 3.3 CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
CHEMBL3732990 136197 0 None - 1 Human 5.0 pEC50 = 5.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 463 10 2 4 3.3 CC(=O)c1ccc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)cc1 nan
87422135 135696 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 424 6 3 5 2.0 CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
CHEMBL3729979 135696 0 None - 1 Human 7.0 pEC50 = 7.0 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 424 6 3 5 2.0 CNCCNC(=O)[C@H]1[C@H](C(=O)Nc2ncc(Br)s2)[C@@H]2C=C[C@H]1C21CC1 nan
22430395 79796 6 None - 1 Human 6.0 pEC50 = 6.0 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 354 3 2 4 3.6 Cc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1F 10.1016/j.bmcl.2006.04.068
CHEMBL212109 79796 6 None - 1 Human 6.0 pEC50 = 6.0 Functional
Activity at human FPRL1-mediated calcium mobilization in CHO cellsActivity at human FPRL1-mediated calcium mobilization in CHO cells
ChEMBL 354 3 2 4 3.6 Cc1ccc(NC(=O)Nc2c(C)n(C)n(-c3ccccc3)c2=O)cc1F 10.1016/j.bmcl.2006.04.068
168278228 191056 0 None 3 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187530 191056 0 None 3 2 Human 6.0 pEC50 = 6.0 Functional
Agonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAgonist activity at human FPR2 transfected in human HL-60 cells assessed as increase in calcium mobilization measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
67495811 136076 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 491 9 2 6 4.0 O=C(Nc1nc(-c2ccccc2)ns1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3732281 136076 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 491 9 2 6 4.0 O=C(Nc1nc(-c2ccccc2)ns1)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67495023 135284 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 10 2 6 2.8 CC(=O)c1ncc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
CHEMBL3727461 135284 0 None - 1 Human 6.0 pEC50 = 6 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 470 10 2 6 2.8 CC(=O)c1ncc(CNC(=O)[C@@H]2[C@@H]3C=C[C@H]([C@H]2C(=O)NCCCCN2CCCC2)C32CC2)s1 nan
67496494 135359 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 9 2 3 4.3 O=C(NCc1cc(C(F)(F)F)ccc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3727911 135359 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 507 9 2 3 4.3 O=C(NCc1cc(C(F)(F)F)ccc1F)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
67496552 135788 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 523 9 2 3 4.8 O=C(NCc1cc(C(F)(F)F)ccc1Cl)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
CHEMBL3730523 135788 0 None - 1 Human 5.0 pEC50 = 5 Functional
Agonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assayAgonist activity at human recombinant ALX receptor expressed in HEK293 cells co-expressing G-protein Galpha16 assessed as effect on calcium response by Fluo-4-AM dye based FLIPR assay
ChEMBL 523 9 2 3 4.8 O=C(NCc1cc(C(F)(F)F)ccc1Cl)[C@@H]1[C@@H]2C=C[C@H]([C@H]1C(=O)NCCCCN1CCCC1)C21CC1 nan
164916036 191563 0 None 147 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5195186 191563 0 None 147 2 Human 8.0 pIC50 = 8 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
168281597 191246 0 None 50 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5190571 191246 0 None 50 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
168291793 191907 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5200365 191907 0 None 2 2 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
168278228 191056 0 None 3 2 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187530 191056 0 None 3 2 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
155517009 170131 0 None -3 2 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by WKYMVM addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by WKYMVM addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
CHEMBL4444320 170131 0 None -3 2 Human 4.9 pIC50 = 4.9 Functional
Antagonist activity against FPR2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by WKYMVM addition and measured for 5 sec for 240 sec by fluorometryAntagonist activity against FPR2 (unknown origin) transfected in human HL60 cells assessed as calcium mobilization preincubated for 30 mins followed by WKYMVM addition and measured for 5 sec for 240 sec by fluorometry
ChEMBL 469 9 3 4 3.4 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)c1ccccc1 10.1039/C9MD00336C
168279295 191022 0 None 91 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187135 191022 0 None 91 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
168283038 190903 0 None 16 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185462 190903 0 None 16 2 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 429 5 2 4 3.4 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cccnc32)cc1 10.1021/acs.jmedchem.1c02203
168272319 190551 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5180261 190551 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
168283383 190820 0 None 3 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184396 190820 0 None 3 2 Human 4.8 pIC50 = 4.8 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
122181411 121888 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay
ChEMBL 415 7 2 4 5.4 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(C)cc2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL3590216 121888 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay
ChEMBL 415 7 2 4 5.4 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(C)cc2)cc1 10.1016/j.bmc.2015.03.062
146597621 191313 0 None 33 2 Human 7.7 pIC50 = 7.7 Functional
Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5191583 191313 0 None 33 2 Human 7.7 pIC50 = 7.7 Functional
Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration
ChEMBL 419 5 2 5 4.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(Cl)cc3)on2)c(F)c1 10.1021/acsmedchemlett.2c00079
163322252 191856 5 None 26 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5199629 191856 5 None 26 2 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
168281748 190861 0 None 6 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184913 190861 0 None 6 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
168279956 191059 0 None 4 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187563 191059 0 None 4 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 460 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
168274924 190245 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5175543 190245 0 None 1 2 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 456 5 2 3 4.8 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)c2ccccc21 10.1021/acs.jmedchem.1c02203
146597625 191238 1 None 47 2 Human 7.6 pIC50 = 7.6 Functional
Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
CHEMBL5190385 191238 1 None 47 2 Human 7.6 pIC50 = 7.6 Functional
Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration
ChEMBL 420 5 2 6 3.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Cl)cc3)o2)c(F)c1 10.1021/acsmedchemlett.2c00079
168286767 191658 0 None 53 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196551 191658 0 None 53 2 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
168293205 192114 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 430 5 2 3 3.7 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCC(F)(F)CC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5203658 192114 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 430 5 2 3 3.7 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCC(F)(F)CC2)cc1 10.1021/acs.jmedchem.1c02203
168282160 190826 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5184490 190826 0 None 1 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3cc(F)ccc32)cc1 10.1021/acs.jmedchem.1c02203
164916034 191666 0 None 6 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5196771 191666 0 None 6 2 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
168269851 189942 0 None 3 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5170711 189942 0 None 3 2 Human 5.5 pIC50 = 5.5 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 442 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
168273654 190302 0 None 6 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5176452 190302 0 None 6 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 437 6 4 4 2.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)NC2CCCCNC2=O)cc1 10.1021/acs.jmedchem.1c02203
168292800 192038 0 None 3 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5202577 192038 0 None 3 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccccc32)cc1 10.1021/acs.jmedchem.1c02203
164916035 192326 3 None 16 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5207056 192326 3 None 16 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
168280238 190930 0 None 6 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185921 190930 0 None 6 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 428 5 2 3 4.0 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccccc3C2)cc1 10.1021/acs.jmedchem.1c02203
168283929 191076 0 None 1 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5187763 191076 0 None 1 2 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2Cc3ccc(F)cc3C2)cc1 10.1021/acs.jmedchem.1c02203
168278342 191127 0 None -1 2 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5188537 191127 0 None -1 2 Human 4.3 pIC50 = 4.3 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 394 5 2 3 3.4 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCCC2)cc1 10.1021/acs.jmedchem.1c02203
168284664 191489 0 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 488 5 2 3 4.9 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21 10.1021/acs.jmedchem.1c02203
CHEMBL5193947 191489 0 None 7 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 488 5 2 3 4.9 CC1(C)CN(C(=O)[C@H](Cc2ccc(C#N)cc2)NC(=O)Nc2ccc(F)cc2)Cc2cc(F)ccc21 10.1021/acs.jmedchem.1c02203
168283359 190788 0 None 5 2 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5183856 190788 0 None 5 2 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 380 5 2 3 3.1 N#Cc1ccc(C[C@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCCC2)cc1 10.1021/acs.jmedchem.1c02203
122181410 121887 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay
ChEMBL 417 7 3 5 4.8 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(O)cc2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL3590215 121887 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay
ChEMBL 417 7 3 5 4.8 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(O)cc2)cc1 10.1016/j.bmc.2015.03.062
11024 685 19 None -4 4 Human 8.1 pIC50 = 8.1 Functional
Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
122583088 685 19 None -4 4 Human 8.1 pIC50 = 8.1 Functional
Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
CHEMBL4784510 685 19 None -4 4 Human 8.1 pIC50 = 8.1 Functional
Agonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migrationAgonist activity at human FPR2 in human HL-60 cells assessed as inhibition of chemotaxis by measuring reduction in cell migration
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acsmedchemlett.2c00079
6263 997 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assayAntagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assay
ChEMBL 721 12 2 6 4.8 CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C 10.1016/j.bmc.2015.03.062
91827351 997 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assayAntagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assay
ChEMBL 721 12 2 6 4.8 CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C 10.1016/j.bmc.2015.03.062
CHEMBL3590218 997 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assayAntagonist activity against FPR2 (unknown origin) pre-treated for 5 mins before addition of Wpep by Fluo4 florescence based intracellular Ca2+ mobilization assay
ChEMBL 721 12 2 6 4.8 CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C 10.1016/j.bmc.2015.03.062
168282231 190938 0 None 16 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
CHEMBL5185982 190938 0 None 16 2 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assayAntagonist activity at human FPR2 transfected in human HL-60 cells assessed as inhibition of WKYMVM-induced intracellular calcium mobilization preincubated for 10 mins followed by WKYMVM addition measured every 5 seconds for 240 secs by Fluo-4-AM dye based fluorescence assay
ChEMBL 446 5 2 3 4.2 N#Cc1ccc(C[C@@H](NC(=O)Nc2ccc(F)cc2)C(=O)N2CCc3ccc(F)cc32)cc1 10.1021/acs.jmedchem.1c02203
122181412 121889 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay
ChEMBL 431 8 2 5 5.1 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(OC)cc2)cc1 10.1016/j.bmc.2015.03.062
CHEMBL3590217 121889 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
Antagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assayAntagonist activity against human FPR2 expressed in rat RBL-2H3 cells pre-treated for 15 mins before addition of WKYMVm or C1 by intracellular Ca2+ mobilization assay
ChEMBL 431 8 2 5 5.1 CCCCOc1ccc(C(=O)NN2Cc3ccccc3NC2c2ccc(OC)cc2)cc1 10.1016/j.bmc.2015.03.062
49834265 272 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
FPR2/ALX internalization into monocytes.FPR2/ALX internalization into monocytes.
Guide to Pharmacology 428 6 1 8 4.0 Cc1cccc(c1)c1oc(nc1C(=O)Nc1cnn(n1)Cc1occ(n1)C(F)(F)C)C 27730665
9511 272 0 None - 1 Human 8.5 pEC50 = 8.5 Functional
FPR2/ALX internalization into monocytes.FPR2/ALX internalization into monocytes.
Guide to Pharmacology 428 6 1 8 4.0 Cc1cccc(c1)c1oc(nc1C(=O)Nc1cnn(n1)Cc1occ(n1)C(F)(F)C)C 27730665
16126783 503 0 None - 1 Human 11.1 pEC50 = 11.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 14 4 4 3.5 CC/C=C\C[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)O)O)O)O 22449948
6239 503 0 None - 1 Human 11.1 pEC50 = 11.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 14 4 4 3.5 CC/C=C\C[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)O)O)O)O 22449948
CHEMBL519495 503 0 None - 1 Human 11.1 pEC50 = 11.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 14 4 4 3.5 CC/C=C\C[C@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)O)O)O)O 22449948
5555 3392 0 None 1 2 Human 11.4 pEC50 = 11.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 14 3 5 3.6 CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)OC)O)O)O 22449948
71519431 3392 0 None 1 2 Human 11.4 pEC50 = 11.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 390 14 3 5 3.6 CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](C/C=C\CCC(=O)OC)O)O)O 22449948
16135249 3174 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23549262
6244 3174 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23549262
71312203 3174 0 None - 1 Human 4.6 pEC50 = 4.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23549262
1023 1660 0 None -47863 5 Mouse 5.3 pEC50 = 5.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
5841 1655 0 None -141253 4 Mouse 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 18606697
5841 1655 0 None -141253 4 Mouse 5.6 pEC50 = 5.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
11751175 3233 0 None -3 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 445 8 2 5 4.8 CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)OC 15308762
6265 3233 0 None -3 2 Human 5.7 pEC50 = 5.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 445 8 2 5 4.8 CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)OC 15308762
1044 424 0 None -1 3 Human 5.9 pEC50 = 5.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10882119
1044 424 0 None -1 3 Human 5.9 pEC50 = 5.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12368905
1044 424 0 None -1 3 Human 5.9 pEC50 = 5.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12560218
1044 424 0 None -1 3 Human 5.9 pEC50 = 5.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16278303
134611881 2321 0 None - 1 Human 6.0 pEC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11015447
5527 2321 0 None - 1 Human 6.0 pEC50 = 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11015447
11751175 3233 0 None 3 2 Mouse 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 445 8 2 5 4.8 CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)OC 23160941
6265 3233 0 None 3 2 Mouse 6.2 pEC50 = 6.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 445 8 2 5 4.8 CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)OC 23160941
5834 1152 0 None 1 2 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 517 7 1 5 5.1 COc1cccc(c1)Cc1cc(C)nn(c1=O)[C@@H](C(=O)Nc1ccc(cc1)Br)c1ccccc1 22607879
73755161 1152 0 None 1 2 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 517 7 1 5 5.1 COc1cccc(c1)Cc1cc(C)nn(c1=O)[C@@H](C(=O)Nc1ccc(cc1)Br)c1ccccc1 22607879
6268 309 7 None 2 3 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 19903830
727787 309 7 None 2 3 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 19903830
CHEMBL1289260 309 7 None 2 3 Human 6.3 pEC50 = 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 19903830
3935 1605 0 None -50 2 Mouse 6.4 pEC50 = 6.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17237393
1047 1939 17 None -281 4 Mouse 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15153530
16131438 1939 17 None -281 4 Mouse 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15153530
56947109 1939 17 None -281 4 Mouse 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15153530
CHEMBL4447799 1939 17 None -281 4 Mouse 6.5 pEC50 = 6.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15153530
6242 3564 0 None - 1 Human 6.6 pEC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9892621
5841 1655 0 None -9999 4 Human 6.7 pEC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16025565
155817495 1196 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15879124
6266 1196 0 None - 1 Mouse 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15879124
24776341 3215 39 None -60 4 Mouse 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 23160941
5831 3215 39 None -60 4 Mouse 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 23160941
CHEMBL379761 3215 39 None -60 4 Mouse 6.9 pEC50 = 6.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 23160941
4865 406 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11160457
4865 406 0 None - 1 Human 7.0 pEC50 = 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11316806
6249 3914 0 None - 1 Human 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11818541
6245 3698 0 None - 1 Human 7.3 pEC50 = 7.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10229829
24776341 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 16697190
5831 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 16697190
CHEMBL379761 3215 39 None -25 4 Human 7.4 pEC50 = 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 16697190
155817496 3572 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14662730
155817496 3572 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17513790
16207728 3572 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14662730
16207728 3572 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17513790
6275 3572 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14662730
6275 3572 0 None - 1 Human 7.7 pEC50 = 7.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17513790
1023 1660 0 None -151 5 Human 7.8 pEC50 = 7.8 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16025565
11024 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
122583088 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
CHEMBL4784510 685 19 None -4 4 Human 8.3 pEC50 = 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
1047 1939 17 None -3 4 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15465011
16131438 1939 17 None -3 4 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15465011
56947109 1939 17 None -3 4 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15465011
CHEMBL4447799 1939 17 None -3 4 Human 8.5 pEC50 = 8.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15465011
6267 3197 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 20542250
25074458 2566 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11435499
25074458 2566 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9853614
6240 2566 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11435499
6240 2566 0 None - 1 Human 8.7 pEC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9853614
6251 3535 0 None - 1 Human 9.0 pEC50 = 9.0 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 14662730
11024 685 19 None 4 4 Mouse 9.3 pEC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
122583088 685 19 None 4 4 Mouse 9.3 pEC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
CHEMBL4784510 685 19 None 4 4 Mouse 9.3 pEC50 = 9.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 32407089
1048 4054 0 None 3 4 Mouse 9.6 pEC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11035102
1048 4054 0 None 3 4 Mouse 9.6 pEC50 = 9.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
1041 2079 0 None - 1 Human 5.2 pEC50 None 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8573582
1039 3234 0 None - 1 Human 5.2 pEC50 None 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 431 7 3 5 4.5 CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)O 17652444
11647668 3234 0 None - 1 Human 5.2 pEC50 None 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology 431 7 3 5 4.5 CCCCOc1ccc(cc1)C(=O)NN1C(Nc2c(C1=O)cccc2)c1ccc(cc1)O 17652444
3934 3293 0 None 6 2 Human 11.9 pEC50 ~ 11.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 14 4 4 3.5 CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@@H]([C@H](C/C=C\CCC(=O)O)O)O)O 20080636
4356 3293 0 None 6 2 Human 11.9 pEC50 ~ 11.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 14 4 4 3.5 CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@@H]([C@H](C/C=C\CCC(=O)O)O)O)O 20080636
73755062 3293 0 None 6 2 Human 11.9 pEC50 ~ 11.9 Functional
UnclassifiedUnclassified
Guide to Pharmacology 376 14 4 4 3.5 CC/C=C\C[C@@H](/C=C/C=C\C=C\C=C\[C@@H]([C@H](C/C=C\CCC(=O)O)O)O)O 20080636
1034 2377 27 None -10 2 Human 12.0 pEC50 ~ 12 Functional
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 20080636
5280914 2377 27 None -10 2 Human 12.0 pEC50 ~ 12 Functional
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 20080636
CHEMBL392438 2377 27 None -10 2 Human 12.0 pEC50 ~ 12 Functional
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 20080636
10079900 2514 0 None - 1 Human 10.0 pIC50 = 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10748237
6250 2514 0 None - 1 Human 10.0 pIC50 = 10 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10748237
1030 3732 0 None -28 2 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10882119
1030 3732 0 None -28 2 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 17687636
1030 3732 0 None -28 2 Human 5.2 pIC50 = 5.2 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 6280748
1040 4063 0 None 4 2 Human 6.6 pIC50 = 6.6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 15210823
6241 883 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19023040
6263 997 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 721 12 2 6 4.8 CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C 23788657
91827351 997 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 721 12 2 6 4.8 CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C 23788657
CHEMBL3590218 997 0 None - 1 Human 7.1 pIC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology 721 12 2 6 4.8 CC([C@H]1CNC(=O)C(=O)N1C[C@@H]1CCCN1C[C@H](N1C[C@@H](Cc2ccc(cc2)O)N(C(=O)C1=O)CC1CCCCC1)Cc1ccc2c(c1)cccc2)C 23788657
1043 2990 0 None - 1 Human 7.0 pIC50 None 7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16025565


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Ligands Receptor Assay information Chemical information
Sel. page Common
name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Affinity)		 # tested GPCRs
(Affinity)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
CHEMBL5271637 193666 0 None - 0 Human 10.7 pEC50 = 10.7 Binding
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux
ChEMBL 420 4 2 5 3.0 COc1cc(F)c([C@@H]2CN3CCON=C3[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1016/j.ejmech.2021.113167
118132792 181644 0 None - 0 Human 10.3 pEC50 = 10.3 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 411 4 4 4 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4776349 181644 0 None - 0 Human 10.3 pEC50 = 10.3 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 411 4 4 4 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
122583080 182785 0 None - 0 Human 10.1 pEC50 = 10.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 4 4 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4790836 182785 0 None - 0 Human 10.1 pEC50 = 10.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 4 4 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
118132866 179684 0 None - 0 Human 10.1 pEC50 = 10.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 343 4 3 3 2.2 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4743917 179684 0 None - 0 Human 10.1 pEC50 = 10.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 343 4 3 3 2.2 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1021/acs.jmedchem.9b02101
122583049 180682 0 None - 0 Human 10.1 pEC50 = 10.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 395 4 4 4 2.2 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4755590 180682 0 None - 0 Human 10.1 pEC50 = 10.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 395 4 4 4 2.2 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
118132864 179710 0 None - 0 Human 10.0 pEC50 = 10.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4744094 179710 0 None - 0 Human 10.0 pEC50 = 10.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
122582941 180975 0 None - 0 Human 10.0 pEC50 = 10.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 395 4 3 3 3.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4758920 180975 0 None - 0 Human 10.0 pEC50 = 10.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 395 4 3 3 3.0 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
135251225 182308 0 None - 0 Human 10.0 pEC50 = 10.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 373 4 3 3 3.1 COc1ccc([C@@H]2CCNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784400 182308 0 None - 0 Human 10.0 pEC50 = 10.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 373 4 3 3 3.1 COc1ccc([C@@H]2CCNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5288361 194396 0 None - 0 Human 9.9 pEC50 = 9.9 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 371 5 2 3 3.0 CCN1C[C@@H](c2ccc(OC)cc2)[C@H](NC(=O)Nc2ccc(F)cc2)C1=O 10.1016/j.ejmech.2021.113167
CHEMBL5284349 194228 0 None - 0 Human 9.9 pEC50 = 9.9 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 512 6 3 4 4.7 CS(=O)(=O)Nc1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)cc1 10.1016/j.ejmech.2021.113167
122583076 182059 1 None - 0 Human 9.9 pEC50 = 9.9 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4781596 182059 1 None - 0 Human 9.9 pEC50 = 9.9 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
118132901 179774 0 None - 0 Human 9.8 pEC50 = 9.8 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F 10.1021/acs.jmedchem.9b02101
CHEMBL4744835 179774 0 None - 0 Human 9.8 pEC50 = 9.8 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F 10.1021/acs.jmedchem.9b02101
122582993 181247 0 None - 0 Human 9.8 pEC50 = 9.8 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 397 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4762030 181247 0 None - 0 Human 9.8 pEC50 = 9.8 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 397 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5281870 194112 0 None - 0 Human 9.8 pEC50 = 9.8 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 416 8 3 6 3.4 COc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2noc(CCO)n2)cc1 10.1016/j.ejmech.2021.113167
118132864 179710 0 None - 0 Human 9.7 pEC50 = 9.7 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4744094 179710 0 None - 0 Human 9.7 pEC50 = 9.7 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
162659259 181209 0 None - 0 Human 9.7 pEC50 = 9.7 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 439 4 3 3 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4761554 181209 0 None - 0 Human 9.7 pEC50 = 9.7 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 439 4 3 3 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Br)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5270733 193625 0 None - 0 Human 9.7 pEC50 = 9.7 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 524 7 3 4 3.6 CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1 10.1016/j.ejmech.2021.113167
124093849 183052 0 None - 0 Human 9.6 pEC50 = 9.6 Binding
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux
ChEMBL 330 4 2 3 3.1 COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL4794375 183052 0 None - 0 Human 9.6 pEC50 = 9.6 Binding
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux
ChEMBL 330 4 2 3 3.1 COc1ccc([C@@H]2COC[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5287715 194368 0 None - 0 Human 9.6 pEC50 = 9.6 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 416 8 3 7 2.4 COc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2nnn(CCO)n2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5273168 193728 0 None - 0 Human 9.6 pEC50 = 9.6 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 450 8 4 6 2.2 COc1ccc(NC(=O)N[C@@H]2/C(=N/OCCO)NC[C@H]2c2c(F)cc(OC)cc2F)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5275581 193839 0 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux
ChEMBL 398 4 2 5 2.3 COc1ccc([C@@H]2CN3C(=O)CON=C3[C@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113167
122583133 181138 0 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 401 4 3 4 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4760897 181138 0 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 401 4 3 4 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 10.1021/acs.jmedchem.9b02101
122582929 181837 0 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 382 4 3 5 2.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4778725 181837 0 None - 0 Human 9.5 pEC50 = 9.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 382 4 3 5 2.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc(C)ns2)c(F)c1 10.1021/acs.jmedchem.9b02101
122582983 180513 0 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 362 4 3 4 1.8 COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4753713 180513 0 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 362 4 3 4 1.8 COc1cnc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
11024 685 19 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 685 19 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 685 19 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583126 179799 0 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4745044 179799 0 None - 0 Human 9.4 pEC50 = 9.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5288386 194398 0 None - 0 Human 9.3 pEC50 = 9.3 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 561 5 2 3 6.0 CP(C)(=O)c1ccccc1-c1ccc(N2CC3(CC3)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F 10.1016/j.ejmech.2021.113167
11024 685 19 None - 0 Mouse 9.3 pEC50 = 9.3 Binding
Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 685 19 None - 0 Mouse 9.3 pEC50 = 9.3 Binding
Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 685 19 None - 0 Mouse 9.3 pEC50 = 9.3 Binding
Agonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assayAgonist activity at mouse FPR2 expressed in CHO cells assessed as reduction cAMP accumulation incubated for 1 hr by TR-FRET assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL5274399 193791 0 None - 0 Human 9.3 pEC50 = 9.3 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 404 9 4 4 2.9 CCc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)/C(N)=N/OCCO)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5270974 193640 0 None - 0 Human 9.2 pEC50 = 9.2 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 443 9 3 6 3.8 CCc1ccc(C[C@H](NC(=O)Nc2ccc(Cl)cc2)c2noc(N(C)CCO)n2)cc1 10.1016/j.ejmech.2021.113167
122583080 182785 0 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 4 4 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4790836 182785 0 None - 0 Mouse 9.2 pEC50 = 9.2 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 4 4 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)c(O)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5286212 194316 0 None - 0 Human 9.2 pEC50 = 9.2 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 422 7 4 3 3.0 N/C(=N\C(=O)CCO)[C@H](Cc1ccc(Cl)cc1)NC(=O)Nc1ccc(Cl)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5280720 194057 0 None - 0 Human 9.2 pEC50 = 9.2 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 506 7 3 6 2.4 CS(=O)(=O)NCC1(c2ccc(N3CCC[C@@H](NC(=O)Nc4cnc(Cl)cn4)C3=O)cc2)CCC1 10.1016/j.ejmech.2021.113167
122582964 180177 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 417 4 3 4 3.6 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4749577 180177 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 417 4 3 4 3.6 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cc3ccccc3s2)c(F)c1 10.1021/acs.jmedchem.9b02101
118132914 179568 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 386 4 3 4 2.2 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C#N)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4742149 179568 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 386 4 3 4 2.2 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C#N)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
71526099 182366 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay
ChEMBL 385 7 4 3 2.2 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O 10.1016/j.ejmech.2021.113167
CHEMBL4785302 182366 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay
ChEMBL 385 7 4 3 2.2 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O 10.1016/j.ejmech.2021.113167
122583009 181383 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 375 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1 10.1016/j.ejmech.2021.113167
CHEMBL4763673 181383 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 375 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1 10.1016/j.ejmech.2021.113167
122582974 179409 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4740375 179409 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
118132817 180301 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F 10.1021/acs.jmedchem.9b02101
CHEMBL4751168 180301 0 None - 0 Human 9.1 pEC50 = 9.1 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)cc1F 10.1021/acs.jmedchem.9b02101
122592369 182996 0 None - 0 Human 9.0 pEC50 = 9.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4793814 182996 0 None - 0 Human 9.0 pEC50 = 9.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
118132868 181394 0 None - 0 Human 9.0 pEC50 = 9.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cccc(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4763824 181394 0 None - 0 Human 9.0 pEC50 = 9.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2cccc(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5275766 193847 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 448 6 2 4 3.9 COc1ccc([C@@H]2CCN(Cc3ccccn3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5278464 193957 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 448 6 2 4 3.9 COc1ccc([C@H]2CCN(Cc3cccnc3)C(=O)[C@@H]2NC(=O)Nc2ccc(F)cc2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5286200 194315 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 473 7 2 3 5.3 COc1cc(F)c([C@H]2CCN(CCC(F)F)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)c(F)c1 10.1016/j.ejmech.2021.113167
CHEMBL5290016 194467 0 None - 0 Human 9.0 pEC50 = 9 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assayAgonist activity at human FPR2 expressed in CHO cells assessed as increase in calcium flux incubated for 50 mins by FLIPR calcium 5 dye based fluorescence assay
ChEMBL 437 5 2 5 4.3 COc1ccc([C@H]2CCN(c3ccnnc3)C[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1016/j.ejmech.2021.113167
122583086 182053 0 None - 0 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 378 4 4 3 2.5 CNc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4781488 182053 0 None - 0 Human 8.9 pEC50 = 8.9 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 378 4 4 3 2.5 CNc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
122583133 181138 0 None - 0 Mouse 8.9 pEC50 = 8.9 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 401 4 3 4 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4760897 181138 0 None - 0 Mouse 8.9 pEC50 = 8.9 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 401 4 3 4 3.1 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)s2)c(F)c1 10.1021/acs.jmedchem.9b02101
122583076 182059 1 None - 0 Mouse 8.8 pEC50 = 8.8 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4781596 182059 1 None - 0 Mouse 8.8 pEC50 = 8.8 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
122583163 179626 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 357 4 3 3 2.5 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(C)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4743084 179626 0 None - 0 Human 8.8 pEC50 = 8.8 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 357 4 3 3 2.5 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(C)c1 10.1021/acs.jmedchem.9b02101
118132940 182745 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 402 4 3 5 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ncc(Cl)s2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4790245 182745 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 402 4 3 5 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ncc(Cl)s2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5282261 194129 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 380 3 3 4 2.0 N#Cc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2cc3c(cc2F)OCC3)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5265888 193437 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 464 4 3 3 3.0 Cc1cccc(C2(NC(=O)N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(Br)cc3F)CC2)n1 10.1016/j.ejmech.2021.113167
CHEMBL5270218 193601 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 475 4 2 4 3.8 CN1CCN(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1 10.1016/j.ejmech.2021.113167
CHEMBL5273483 193744 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 474 4 2 4 3.9 O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O 10.1016/j.ejmech.2021.113167
44413534 138354 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL377226 138354 0 None - 0 Human 8.0 pEC50 = 8 Binding
Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL5277650 193918 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 503 4 2 4 3.7 CC(=O)N1CCN(c2ccc(N3CCC[C@@H](NC(=O)Nc4ccc(C(F)(F)F)cc4)C3=O)cc2)CC1 10.1016/j.ejmech.2021.113167
CHEMBL5281612 194096 0 None - 0 Human 7.0 pEC50 = 7 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 420 4 3 3 2.9 Cc1cccc(C2(NC(=O)N[C@@H]3C(=O)NC[C@H]3c3c(F)cc(Cl)cc3F)CC2)n1 10.1016/j.ejmech.2021.113167
CHEMBL5267353 193498 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 565 6 3 4 4.8 CP(C)(=O)c1ccccc1-c1ccc(N2CC(CO)[C@@H](NC(=O)Nc3ccc(Cl)cc3F)C2=O)c(F)c1F 10.1016/j.ejmech.2021.113167
162644272 181805 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 345 4 3 3 2.7 COc1ccc([C@@H]2NC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4778312 181805 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 345 4 3 3 2.7 COc1ccc([C@@H]2NC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5278883 193979 0 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 451 5 1 5 4.1 COc1cccc(-c2cc(C#N)c(C)n(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL5289577 194446 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay
ChEMBL 385 7 4 3 2.2 CC(C)C[C@@H](NC(=O)Nc1ccc(Br)cc1)C(=O)NCC(=O)O 10.1016/j.ejmech.2021.113167
11024 685 19 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
122583088 685 19 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL4784510 685 19 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL5284927 194249 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn([C@H](C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL5284145 194223 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay
ChEMBL 455 6 1 5 3.9 COc1ccc(Cc2c(C)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)cc1 10.1016/j.ejmech.2021.113167
11024 685 19 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitmentAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 685 19 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitmentAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 685 19 None - 0 Human 6.9 pEC50 = 6.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitmentAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
162676377 183323 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 402 4 3 3 3.9 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cccnc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4797594 183323 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 402 4 3 3 3.9 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cccnc2)CCCC1 10.1016/j.ejmech.2021.113194
162663800 181892 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 402 6 3 3 3.8 O=C(Nc1ccc(Br)cc1)N[C@@H](CC1CC1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
CHEMBL4779558 181892 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 402 6 3 3 3.8 O=C(Nc1ccc(Br)cc1)N[C@@H](CC1CC1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
122582973 180755 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 393 5 3 3 2.9 CCOc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4756320 180755 0 None - 0 Human 7.9 pEC50 = 7.9 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 393 5 3 3 2.9 CCOc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
162649751 180065 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 417 5 3 4 3.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnn1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4748148 180065 0 None - 0 Human 5.9 pEC50 = 5.9 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 417 5 3 4 3.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnn1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL5279627 194007 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay
ChEMBL 517 7 1 5 5.2 COc1cccc(Cc2c(-c3ccccc3)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
122487986 175950 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL4588649 175950 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assayAgonist activity at human recombinant FPR2 stably transfected in Flp-In-CHO cells assessed as ERK1/2 phosphorylation incubated for 1 hr by Alphascreen fluorescence assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL5279215 193995 0 None - 0 Human 5.8 pEC50 = 5.8 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 484 9 4 5 3.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(O)cc3)CC2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5265951 193441 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 483 6 2 5 3.4 O=C(Nc1ccc(Cl)cn1)N[C@@H]1CCCN(c2ccc(C3(CN4CCOCC4)CC3)cc2)C1=O 10.1016/j.ejmech.2021.113167
CHEMBL5273627 193747 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 525 7 4 6 1.7 CS(=O)(=O)NCC1(c2ccc(N3C[C@@H](O)C[C@@H](NC(=O)Nc4ncc(Cl)cc4F)C3=O)cc2)CC1 10.1016/j.ejmech.2021.113167
CHEMBL5284802 194242 0 None - 0 Human 7.8 pEC50 = 7.8 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 595 7 3 6 4.6 COc1cc(-c2ccccc2NS(C)(=O)=O)ccc1N1CCC[C@@H](NC(=O)Nc2ncc(C(F)(F)F)cc2F)C1=O 10.1016/j.ejmech.2021.113167
CHEMBL5265989 193443 0 None - 0 Human 6.8 pEC50 = 6.8 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 484 9 4 5 3.9 COc1ccc(NC(=O)N[C@@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3cccc(O)c3)CC2)cc1 10.1016/j.ejmech.2021.113167
162663817 181904 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 419 4 3 4 3.6 Cc1nn(C)cc1NC(=O)C1(NC(=O)Nc2ccc(Br)cc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4779714 181904 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 419 4 3 4 3.6 Cc1nn(C)cc1NC(=O)C1(NC(=O)Nc2ccc(Br)cc2)CCCC1 10.1016/j.ejmech.2021.113194
71362579 170856 7 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin2 recruitment after 90 mins by chemiluminescent assayAgonist activity at FPR2 (unknown origin) expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin2 recruitment after 90 mins by chemiluminescent assay
ChEMBL 856 26 10 11 1.8 CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(=O)O 10.1021/acs.jmedchem.8b00435
CHEMBL4454321 170856 7 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin2 recruitment after 90 mins by chemiluminescent assayAgonist activity at FPR2 (unknown origin) expressed in CHOK1 cells harboring beta-galactosidase enzyme fused beta-arrestin assessed as increase in beta-arrestin2 recruitment after 90 mins by chemiluminescent assay
ChEMBL 856 26 10 11 1.8 CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(=O)O 10.1021/acs.jmedchem.8b00435
162654865 180551 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 433 5 3 4 3.8 Cc1nn(C)cc1NC(=O)C(NC(=O)Nc1ccc(Br)cc1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4754119 180551 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 433 5 3 4 3.8 Cc1nn(C)cc1NC(=O)C(NC(=O)Nc1ccc(Br)cc1)C1CCCC1 10.1016/j.ejmech.2021.113194
122583009 181383 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 375 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4763673 181383 0 None - 0 Human 8.7 pEC50 = 8.7 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 375 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(C)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5274258 193781 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 60 mins by FLIPR assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 60 mins by FLIPR assay
ChEMBL 427 7 0 8 4.1 Cc1cccc(-c2oc(C)nc2C(=O)Cc2cnn(Cc3nc(C(C)(F)F)co3)n2)c1 10.1016/j.ejmech.2021.113167
CHEMBL5288663 194415 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at FPR2 (unknown origin) assessed as increase in calcium fluxAgonist activity at FPR2 (unknown origin) assessed as increase in calcium flux
ChEMBL 398 3 2 6 2.5 O=C(Nc1ccc(F)cc1)N[C@@H]1c2nnnn2C[C@H]1c1cc2c(cc1F)OCC2 10.1016/j.ejmech.2021.113167
CHEMBL5276954 193895 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 523 5 2 4 5.5 CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3csc(Cl)c3)C2=O)c(F)c1F 10.1016/j.ejmech.2021.113167
162645753 179488 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 444 6 3 3 4.9 O=C(Nc1ccc(Br)cc1)NC(CC1CCCCC1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
CHEMBL4741207 179488 0 None - 0 Human 5.7 pEC50 = 5.7 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 444 6 3 3 4.9 O=C(Nc1ccc(Br)cc1)NC(CC1CCCCC1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
CHEMBL5278986 193983 0 None - 0 Human 7.7 pEC50 = 7.7 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 512 6 3 6 3.3 Cc1cnc(NC(=O)N[C@@H]2CCCN(c3ccc(-c4ccccc4NS(C)(=O)=O)cc3F)C2=O)cn1 10.1016/j.ejmech.2021.113167
CHEMBL5276622 193883 0 None - 0 Human 6.7 pEC50 = 6.7 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 385 7 4 3 2.2 CC(C)C[C@H](NC(=O)CNC(=O)Nc1ccc(Br)cc1)C(=O)O 10.1016/j.ejmech.2021.113167
162664348 182141 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 318 5 2 2 4.1 COc1ccc(CC(C)NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4782531 182141 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 318 5 2 2 4.1 COc1ccc(CC(C)NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5284816 194244 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 342 5 3 2 3.3 CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5284060 194219 0 None - 0 Human 7.6 pEC50 = 7.6 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 517 5 2 3 5.5 CP(C)(=O)c1ccccc1-c1ccc(N2CC[C@@H](NC(=O)Nc3ccc(Cl)cc3)C2=O)c(F)c1F 10.1016/j.ejmech.2021.113167
162657722 181118 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 436 4 3 3 4.6 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccc(Cl)nc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4760670 181118 0 None - 0 Human 5.6 pEC50 = 5.6 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 436 4 3 3 4.6 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2ccc(Cl)nc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL5280794 194061 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 459 9 4 4 4.0 COc1ccc(NC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5287909 194377 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 460 4 2 3 5.0 O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(N3CCCCC3)cc2)C1=O 10.1016/j.ejmech.2021.113167
162673503 182976 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 365 3 3 2 3.0 O=C(Nc1ccc(F)cc1)N[C@@H]1C(=O)NC[C@H]1c1ccc(Cl)cc1F 10.1021/acs.jmedchem.9b02101
CHEMBL4793557 182976 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 365 3 3 2 3.0 O=C(Nc1ccc(F)cc1)N[C@@H]1C(=O)NC[C@H]1c1ccc(Cl)cc1F 10.1021/acs.jmedchem.9b02101
122582962 182688 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 5 3 4 2.4 COc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2c(F)cc(OC)cc2F)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4789579 182688 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 391 5 3 4 2.4 COc1ccc(NC(=O)N[C@@H]2C(=O)NC[C@H]2c2c(F)cc(OC)cc2F)cc1 10.1021/acs.jmedchem.9b02101
11024 685 19 None - 0 Mouse 8.5 pEC50 = 8.5 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 685 19 None - 0 Mouse 8.5 pEC50 = 8.5 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 685 19 None - 0 Mouse 8.5 pEC50 = 8.5 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL5285150 194259 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assayAgonist activity at human FPR2 expressed in HEK cells assessed as increase in calcium flux incubated for 40 mins by Fluo-4 staining based FLIPR assay
ChEMBL 403 7 4 3 2.3 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1F)C(=O)NCC(=O)O 10.1016/j.ejmech.2021.113167
162674826 183232 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 347 6 3 3 2.6 COc1ccc(CC(NC(=O)Nc2ccc(Cl)cc2)C(N)=O)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4796468 183232 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 347 6 3 3 2.6 COc1ccc(CC(NC(=O)Nc2ccc(Cl)cc2)C(N)=O)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5276878 193891 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 371 7 4 3 1.9 CCC[C@H](NC(=O)CNC(=O)Nc1ccc(Br)cc1)C(=O)O 10.1016/j.ejmech.2021.113167
124092285 181494 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 348 6 3 3 3.2 COc1ccc(CC(NC(=O)Nc2ccc(Cl)cc2)C(=O)O)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4765025 181494 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 348 6 3 3 3.2 COc1ccc(CC(NC(=O)Nc2ccc(Cl)cc2)C(=O)O)cc1 10.1021/acs.jmedchem.9b02101
44413534 138354 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells by beta-arrestin recruitment assayAgonist activity at human FPR2 expressed in CHO-K1 cells by beta-arrestin recruitment assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL377226 138354 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells by beta-arrestin recruitment assayAgonist activity at human FPR2 expressed in CHO-K1 cells by beta-arrestin recruitment assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL5284816 194244 0 None - 0 Human 5.5 pEC50 = 5.5 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 342 5 3 2 3.3 CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5277178 193902 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 481 6 3 4 3.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)NC2(c3ccc4cc(OC)ccc4c3)CC2)c(F)c1 10.1016/j.ejmech.2021.113167
118132917 182978 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4793603 182978 0 None - 0 Human 7.5 pEC50 = 7.5 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc([C@H]2CNC(=O)[C@@H]2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5280317 194037 0 None - 0 Human 6.5 pEC50 = 6.5 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 419 7 4 3 2.4 O=C(CNC(=O)Nc1ccc(Br)cc1)N[C@@H](Cc1ccccc1)C(=O)O 10.1016/j.ejmech.2021.113167
CHEMBL5270501 193612 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 475 4 2 5 3.3 O=C(Nc1ccc(C(F)(F)F)cn1)N[C@@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O 10.1016/j.ejmech.2021.113167
11024 685 19 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
122583088 685 19 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL4784510 685 19 None - 0 Mouse 6.4 pEC50 = 6.4 Binding
Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL5288141 194385 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 499 5 2 4 4.9 O=C(Nc1ccc(Cl)cc1F)N[C@@H]1CCN(c2ccc(-c3cnn(C(F)F)c3)c(F)c2F)C1=O 10.1016/j.ejmech.2021.113167
118132818 179629 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 377 4 3 3 2.9 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(Cl)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4743133 179629 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 377 4 3 3 2.9 COc1ccc([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(Cl)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5282051 194118 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assayAgonist activity at human FPR2 expressed in HEK293 cells assessed as increase in calcium flux incubated for 45 mins by Fluo-4 AM dye based fluorescence assay
ChEMBL 334 6 3 3 3.1 COc1ccc(C[C@H](CO)NC(=O)Nc2ccc(Cl)cc2)cc1 10.1016/j.ejmech.2021.113167
122582903 182859 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 396 4 3 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cn2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4792002 182859 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 396 4 3 4 2.4 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(Cl)cn2)c(F)c1 10.1021/acs.jmedchem.9b02101
122582974 179409 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4740375 179409 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 359 4 3 3 2.8 COc1ccc(C2CNC(=O)C2NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL5270967 193639 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 497 5 3 3 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(-c3ccccc3C(=O)O)cc2)C1=O 10.1016/j.ejmech.2021.113167
CHEMBL5271664 193667 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 496 5 3 3 4.8 NC(=O)c1ccccc1-c1ccc(N2CCCC(NC(=O)Nc3ccc(C(F)(F)F)cc3)C2=O)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5277119 193900 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 421 4 2 2 4.9 O=C(Nc1ccccc1F)N[C@@H]1CCCN(c2ccc(-c3ccccc3F)cc2)C1=O 10.1016/j.ejmech.2021.113167
CHEMBL5278412 193956 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 471 4 2 2 5.8 O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(-c3ccccc3F)cc2)C1=O 10.1016/j.ejmech.2021.113167
CHEMBL5287828 194374 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 496 5 3 3 4.8 NC(=O)c1ccccc1-c1ccc(N2CCC[C@H](NC(=O)Nc3ccc(C(F)(F)F)cc3)C2=O)cc1 10.1016/j.ejmech.2021.113167
24776341 3215 39 None - 0 Human 7.4 pEC50 = 7.4 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
5831 3215 39 None - 0 Human 7.4 pEC50 = 7.4 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
CHEMBL379761 3215 39 None - 0 Human 7.4 pEC50 = 7.4 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 384 4 2 4 4.6 O=C(Nc1c(C(C)C)n(n(c1=O)c1ccccc1)C)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.8b01912
CHEMBL5282050 194117 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 459 9 4 4 4.0 COc1ccc(NC(=O)N[C@H](Cc2ccc(O)cc2)C(=O)NCC2(c3ccccc3)CC2)cc1 10.1016/j.ejmech.2021.113167
162659418 181210 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 433 5 3 4 4.3 CC(C)n1cc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1 10.1016/j.ejmech.2021.113194
CHEMBL4761559 181210 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 433 5 3 4 4.3 CC(C)n1cc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1 10.1016/j.ejmech.2021.113194
162671881 182820 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 432 5 3 4 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCOCC1 10.1016/j.ejmech.2021.113194
CHEMBL4791407 182820 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 432 5 3 4 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCOCC1 10.1016/j.ejmech.2021.113194
162645814 179612 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 404 6 3 3 4.0 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
CHEMBL4742937 179612 0 None - 0 Human 5.4 pEC50 = 5.4 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 404 6 3 3 4.0 CC(C)C[C@H](NC(=O)Nc1ccc(Br)cc1)C(=O)Nc1cccnc1 10.1016/j.ejmech.2021.113194
122582886 183324 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2F)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4797598 183324 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 379 4 3 3 2.5 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccccc2F)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5271505 193664 0 None - 0 Human 7.4 pEC50 = 7.4 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assayAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based FLIPR-fluorometeric assay
ChEMBL 455 6 1 5 3.9 COc1cccc(Cc2c(C)c(C)nn(CC(=O)Nc3ccc(Br)cc3)c2=O)c1 10.1016/j.ejmech.2021.113167
CHEMBL5288471 194404 0 None - 0 Human 6.4 pEC50 = 6.4 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 446 5 3 3 3.9 NC(=O)c1ccccc1-c1ccc(N2CCC[C@@H](NC(=O)Nc3ccc(F)cc3)C2=O)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5283221 194169 0 None - 0 Human 7.3 pEC50 = 7.3 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 469 5 3 3 3.6 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)NC2(c3cccc(C(F)(F)F)c3)CC2)c(F)c1 10.1016/j.ejmech.2021.113167
CHEMBL5282707 194146 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 497 5 3 3 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N[C@@H]1CCCN(c2ccc(-c3ccccc3C(=O)O)cc2)C1=O 10.1016/j.ejmech.2021.113167
122582977 182259 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 377 4 3 2 3.1 CCc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4783963 182259 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 377 4 3 2 3.1 CCc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
44413534 138354 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
CHEMBL377226 138354 0 None - 0 Mouse 7.3 pEC50 = 7.3 Binding
Agonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at mouse FPR2 expressed in CHO-A12 cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 398 3 2 4 4.8 Cn1c(C(C)(C)C)c(NC(=O)Nc2ccc(Cl)cc2)c(=O)n1-c1ccccc1 10.1016/j.ejmech.2021.113167
162673364 182975 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 394 5 4 3 2.2 O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CNC1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4793549 182975 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 394 5 4 3 2.2 O=C(Nc1ccc(Br)cc1)NC(C(=O)NC1CNC1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL5273815 193757 0 None - 0 Human 6.3 pEC50 = 6.3 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 474 4 2 4 3.9 O=C(Nc1ccc(C(F)(F)F)cc1)N[C@H]1CCCN(c2ccc(N3CC4(COC4)C3)cc2)C1=O 10.1016/j.ejmech.2021.113167
CHEMBL5284903 194248 0 None - 0 Human 5.3 pEC50 = 5.3 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 399 8 4 3 2.6 CC(C)C[C@H](NC(=O)CCNC(=O)Nc1ccc(Br)cc1)C(=O)O 10.1016/j.ejmech.2021.113167
CHEMBL5283999 194215 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 547 5 2 5 4.9 CC1(C)CN(c2ccc(-c3ccccc3P(C)(C)=O)c(F)c2F)C(=O)[C@@H]1NC(=O)Nc1cnc(Cl)cn1 10.1016/j.ejmech.2021.113167
124092515 181100 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 334 6 3 3 3.1 COc1ccc(CC(CO)NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
CHEMBL4760555 181100 0 None - 0 Human 8.2 pEC50 = 8.2 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 334 6 3 3 3.1 COc1ccc(CC(CO)NC(=O)Nc2ccc(Cl)cc2)cc1 10.1021/acs.jmedchem.9b02101
146035589 173705 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4536334 173705 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 483 10 1 6 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2cccc(OC)c2OC)c1=O 10.1021/acs.jmedchem.8b01912
162660629 181243 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 417 5 3 4 3.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cncnc1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4761978 181243 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 417 5 3 4 3.6 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cncnc1)C1CCCC1 10.1016/j.ejmech.2021.113194
146035588 170872 2 None - 0 Human 7.2 pEC50 = 7.2 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL4454594 170872 2 None - 0 Human 7.2 pEC50 = 7.2 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 453 9 1 5 5.2 CCCCC(C(=O)Nc1ccc(Cl)cc1)n1nc(C)cc(Cc2ccccc2OC)c1=O 10.1021/acs.jmedchem.8b01912
CHEMBL5267880 193518 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 484 9 4 5 3.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3cccc(O)c3)CC2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5274109 193770 0 None - 0 Human 5.2 pEC50 = 5.2 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 484 9 4 5 3.9 COc1ccc(NC(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCC2(c3ccc(O)cc3)CC2)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5273792 193756 0 None - 0 Human 7.2 pEC50 = 7.2 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 547 7 2 8 4.9 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2nnc(-c3ccc(Oc4ccc(C(F)(F)F)nc4)cc3)o2)c(F)c1 10.1016/j.ejmech.2021.113167
162653376 180361 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 403 4 3 4 3.3 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cncnc2)CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4751781 180361 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 403 4 3 4 3.3 O=C(Nc1ccc(Br)cc1)NC1(C(=O)Nc2cncnc2)CCCC1 10.1016/j.ejmech.2021.113194
162660631 181253 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 416 5 3 3 4.2 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4762142 181253 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 416 5 3 3 4.2 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CCCC1 10.1016/j.ejmech.2021.113194
162653824 180464 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 447 6 3 4 4.5 CC(C)n1cc(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)cn1 10.1016/j.ejmech.2021.113194
CHEMBL4753061 180464 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 447 6 3 4 4.5 CC(C)n1cc(NC(=O)C(NC(=O)Nc2ccc(Br)cc2)C2CCCC2)cn1 10.1016/j.ejmech.2021.113194
CHEMBL5276320 193869 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 492 6 3 4 4.4 COc1ccc(NC(=O)N[C@@H]2CCCN(c3ccc(-c4ccccc4C(N)=O)cc3)C2=O)cc1Cl 10.1016/j.ejmech.2021.113167
162655466 180770 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 388 5 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CC1 10.1016/j.ejmech.2021.113194
CHEMBL4756434 180770 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 388 5 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)Nc1cccnc1)C1CC1 10.1016/j.ejmech.2021.113194
122582993 181247 0 None - 0 Mouse 8.1 pEC50 = 8.1 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 397 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4762030 181247 0 None - 0 Mouse 8.1 pEC50 = 8.1 Binding
Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 397 4 3 3 2.7 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)c(F)c2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL5284816 194244 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 342 5 3 2 3.3 CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
CHEMBL5291461 194510 0 None - 0 Human 6.1 pEC50 = 6.1 Binding
Agonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assayAgonist activity at human FPR2 expressed in CHO cells assessed as cAMP level incubated for 1.5 hr by HTRF assay
ChEMBL 435 6 2 5 4.3 COc1cc(F)c([C@@H]2CNC(=O)[C@H]2Nc2cc(-c3ccc(C(F)F)cc3)on2)c(F)c1 10.1016/j.ejmech.2021.113167
CHEMBL5285738 194290 0 None - 0 Human 5.1 pEC50 = 5.1 Binding
Agonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysisAgonist activity at human FPR2 transfected in HL-60 cells assessed as increase in intracellular calcium flux incubated for 30 mins by Fluo-4 AM dye based fluorometer analysis
ChEMBL 399 4 2 4 2.6 O=C(Cn1c(=O)[nH]cc(-c2ccccc2)c1=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
122582965 180913 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 374 3 3 3 2.4 N#Cc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
CHEMBL4758129 180913 0 None - 0 Human 8.0 pEC50 = 8.0 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 374 3 3 3 2.4 N#Cc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 10.1021/acs.jmedchem.9b02101
162658091 181028 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 423 6 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)NCC1CCCO1)C1CCCC1 10.1016/j.ejmech.2021.113194
CHEMBL4759517 181028 0 None - 0 Human 6.0 pEC50 = 6.0 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 423 6 3 3 3.4 O=C(Nc1ccc(Br)cc1)NC(C(=O)NCC1CCCO1)C1CCCC1 10.1016/j.ejmech.2021.113194
122487986 175950 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
CHEMBL4588649 175950 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assayBiased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphascreen assay
ChEMBL 411 6 1 5 4.0 COc1cccc(Cc2cc(C)nn(C(C)C(=O)Nc3ccc(Cl)cc3)c2=O)c1 10.1021/acs.jmedchem.8b01912
162644943 179377 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 416 4 3 3 4.2 Cc1cncc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)c1 10.1016/j.ejmech.2021.113194
CHEMBL4739971 179377 0 None - 0 Human 5.0 pEC50 = 5.0 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 416 4 3 3 4.2 Cc1cncc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)c1 10.1016/j.ejmech.2021.113194
6268 309 7 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.9b02101
727787 309 7 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.9b02101
CHEMBL1289260 309 7 None - 0 Human 6.0 pEC50 = 6 Binding
Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric methodAgonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanning fluorometric method
ChEMBL 304 5 2 2 3.7 COc1ccc(cc1)CCNC(=O)Nc1ccc(cc1)Cl 10.1021/acs.jmedchem.9b02101
162672626 183064 0 None - 0 Human 5.0 pEC50 = 5 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 416 4 3 3 4.2 Cc1ccc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1 10.1016/j.ejmech.2021.113194
CHEMBL4794472 183064 0 None - 0 Human 5.0 pEC50 = 5 Binding
Agonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assayAgonist activity at human FPR2 expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment incubated for 150 mins by beta-galactosidase based PathHunter assay
ChEMBL 416 4 3 3 4.2 Cc1ccc(NC(=O)C2(NC(=O)Nc3ccc(Br)cc3)CCCC2)cn1 10.1016/j.ejmech.2021.113194
CHEMBL5284816 194244 0 None - 0 Human 5.0 pEC50 = 5 Binding
Agonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assayAgonist activity at FPR2 (unknown origin) expressed in CHO/Galpha16 cells assessed as increase in calcium flux by FLIPR assay
ChEMBL 342 5 3 2 3.3 CC(C)C(C(=O)O)C(C)NC(=O)Nc1ccc(Br)cc1 10.1016/j.ejmech.2021.113167
134263912 169882 0 None - 0 Human 10.0 pIC50 = 10 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4440913 169882 0 None - 0 Human 10.0 pIC50 = 10 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
153047598 175341 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4574711 175341 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
153047597 171407 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4462922 171407 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
134264894 169594 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4436717 169594 0 None - 0 Human 9.1 pIC50 = 9.1 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
153047597 171407 0 None - 0 Human 9.0 pIC50 = 9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4462922 171407 0 None - 0 Human 9.0 pIC50 = 9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
153047597 171407 0 None - 0 Human 9.0 pIC50 = 9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4462922 171407 0 None - 0 Human 9.0 pIC50 = 9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
10138 40 0 None - 0 Human 9.0 pIC50 = 9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
134264089 40 0 None - 0 Human 9.0 pIC50 = 9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
CHEMBL4536276 40 0 None - 0 Human 9.0 pIC50 = 9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
153047598 175341 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4574711 175341 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
1034 2377 27 None 1 2 Human 8.8 pIC50 = 8.8 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
5280914 2377 27 None 1 2 Human 8.8 pIC50 = 8.8 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
CHEMBL392438 2377 27 None 1 2 Human 8.8 pIC50 = 8.8 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
1034 2377 27 None 1 2 Human 8.7 pIC50 = 8.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
5280914 2377 27 None 1 2 Human 8.7 pIC50 = 8.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
CHEMBL392438 2377 27 None 1 2 Human 8.7 pIC50 = 8.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
153047598 175341 0 None - 0 Human 8.0 pIC50 = 8 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4574711 175341 0 None - 0 Human 8.0 pIC50 = 8 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
137650732 157280 0 None - 0 Human 8.0 pIC50 = 8 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2285 73 13 21 12.0 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4077102 157280 0 None - 0 Human 8.0 pIC50 = 8 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2285 73 13 21 12.0 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)Cc3ccc(F)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
1034 2377 27 None 1 2 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
5280914 2377 27 None 1 2 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
CHEMBL392438 2377 27 None 1 2 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
137657539 159767 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1524 61 23 17 -1.2 CCCCCCCCCCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)NCC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)C(C)C 10.1021/acs.jmedchem.7b00489
CHEMBL4105404 159767 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1524 61 23 17 -1.2 CCCCCCCCCCCCCCCC(=O)N[C@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](C(=O)N[C@H](CCCCN)C(=O)NCC(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CCCNC(=N)N)C(N)=O)C(C)C 10.1021/acs.jmedchem.7b00489
153047597 171407 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4462922 171407 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
137631898 156380 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1599 51 9 15 9.1 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4066521 156380 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1599 51 9 15 9.1 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
137647141 157595 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2177 73 13 21 11.2 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4081147 157595 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2177 73 13 21 11.2 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
137644238 158419 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1888 62 11 18 10.1 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4090485 158419 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1888 62 11 18 10.1 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
153047598 175341 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4574711 175341 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
134263912 169882 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4440913 169882 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
134265014 169494 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4434857 169494 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
134263912 169882 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4440913 169882 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
1034 2377 27 None 1 2 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
5280914 2377 27 None 1 2 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
CHEMBL392438 2377 27 None 1 2 Human 7.7 pIC50 = 7.7 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
137636433 156034 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2261 73 13 21 13.0 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4062611 156034 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2261 73 13 21 13.0 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)Cc3ccc(C)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
134263912 169882 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4440913 169882 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
153047598 175341 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4574711 175341 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
1034 2377 27 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
5280914 2377 27 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
CHEMBL392438 2377 27 None 1 2 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
134275888 171256 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 326 8 3 7 0.9 COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@H](C)O 10.1016/j.ejmech.2018.10.049
CHEMBL4460558 171256 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 326 8 3 7 0.9 COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@H](C)O 10.1016/j.ejmech.2018.10.049
155546686 173612 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 326 8 3 7 0.9 COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@@H](C)O 10.1016/j.ejmech.2018.10.049
CHEMBL4534051 173612 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 326 8 3 7 0.9 COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@@H](C)O 10.1016/j.ejmech.2018.10.049
137653536 158751 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1021 29 5 9 7.0 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4094101 158751 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1021 29 5 9 7.0 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
137645526 157698 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1310 40 7 12 8.1 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4082093 157698 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1310 40 7 12 8.1 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
134265014 169494 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4434857 169494 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
134264414 174341 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4551559 174341 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
134263912 169882 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4440913 169882 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
134264894 169594 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4436717 169594 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
134264414 174341 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4551559 174341 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-1beta secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
155546686 173612 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 326 8 3 7 0.9 COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@@H](C)O 10.1016/j.ejmech.2018.10.049
CHEMBL4534051 173612 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 326 8 3 7 0.9 COC(=O)CCC[C@H](O)[C@H](O)/C=C/c1nc(C)n(C)c1[C@@H](C)O 10.1016/j.ejmech.2018.10.049
134265014 169494 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4434857 169494 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
134264894 169594 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 354 10 3 7 1.6 CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4436717 169594 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 354 10 3 7 1.6 CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
153047597 171407 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4462922 171407 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
137634576 156021 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2261 73 13 21 14.5 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4062488 156021 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2261 73 13 21 14.5 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)[C@@H](C)c3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
137639628 156895 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2467 84 15 24 12.2 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4072333 156895 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2467 84 15 24 12.2 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
155561936 175707 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4582724 175707 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
153047597 171407 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4462922 171407 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
134264414 174341 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4551559 174341 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
10138 40 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
134264089 40 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
CHEMBL4536276 40 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IFNgamma secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
134264414 174341 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4551559 174341 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
134264414 174341 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4551559 174341 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
137638855 156956 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2756 95 17 27 13.2 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4073052 156956 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2756 95 17 27 13.2 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL3588930 211781 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assay
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1 10.1021/acs.jmedchem.7b00489
137639605 156877 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2261 73 13 21 14.5 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4072201 156877 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2261 73 13 21 14.5 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)[C@H](C)c3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
10138 40 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
134264089 40 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
CHEMBL4536276 40 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
134265014 169494 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4434857 169494 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
10138 40 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
134264089 40 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
CHEMBL4536276 40 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
CHEMBL3588930 211781 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Allosteric antagonist activity against FPR2 (unknown origin)Allosteric antagonist activity against FPR2 (unknown origin)
ChEMBL None None None CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1)[C@@H](C)c1ccccc1 10.1016/j.bmc.2015.03.062
137651557 157455 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2501 73 13 21 13.7 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4079416 157455 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2501 73 13 21 13.7 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)Cc3cc(F)c(F)c(F)c3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
134264414 174341 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4551559 174341 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
11024 685 19 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assayAgonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
122583088 685 19 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assayAgonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
CHEMBL4784510 685 19 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assayAgonist activity at FPR2 in human HL-60 cells assessed as reduction in chemoattractant induced chemotaxis by luminescence cell viability assay
ChEMBL 361 4 3 3 2.4 COc1cc(F)c(c(c1)F)[C@@H]1CNC(=O)[C@H]1NC(=O)Nc1ccccc1 10.1021/acs.jmedchem.9b02101
134264894 169594 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4436717 169594 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-12p70 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 354 10 3 7 1.6 CCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
155561936 175707 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4582724 175707 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
134265014 169494 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4434857 169494 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
155561936 175707 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4582724 175707 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
16143873 159588 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assay
ChEMBL 1712 54 23 19 -0.6 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4103322 159588 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation measured up to 20 mins by isoluminol-based chemiluminescence assay
ChEMBL 1712 54 23 19 -0.6 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
134263912 169882 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
CHEMBL4440913 169882 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](O)c1c(/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC)nc(C)n1C 10.1016/j.ejmech.2018.10.049
134265014 169494 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
CHEMBL4434857 169494 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for 30 mins followed by LPS stimulation for 24 hrs by luciferase reporter gene assay
ChEMBL 459 14 3 7 4.8 CCCCC[C@H](O)c1nc(-c2ccccc2)oc1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC(C)C 10.1016/j.ejmech.2018.10.049
153047598 175341 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
CHEMBL4574711 175341 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 506 14 3 7 5.2 CCCCC[C@@H](O)c1nc(-c2ccccc2)n(-c2ccccc2)c1/C=C/[C@@H](O)[C@@H](O)CCCC(=O)OC 10.1016/j.ejmech.2018.10.049
1034 2377 27 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
5280914 2377 27 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
CHEMBL392438 2377 27 None 1 2 Human 8.1 pIC50 = 8.1 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in TNFalpha secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 10.1016/j.ejmech.2018.10.049
137632100 156442 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 731 18 3 6 6.0 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4067361 156442 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 731 18 3 6 6.0 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccccc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
10138 40 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
134264089 40 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
CHEMBL4536276 40 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assayAgonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring reduction in IL-6 secretion pretreated for 30 mins followed by LPS stimulation for 24 hrs by electrochemiluminescence assay
ChEMBL 382 12 3 7 2.4 CCCCC[C@H](c1c(/C=C/[C@H]([C@H](CCCC(=O)OC)O)O)nc(n1C)C)O 10.1016/j.ejmech.2018.10.049
137645180 157901 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1524 61 23 17 -1.2 CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C(C)C 10.1021/acs.jmedchem.7b00489
CHEMBL4084411 157901 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 1524 61 23 17 -1.2 CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)C(C)C 10.1021/acs.jmedchem.7b00489
137647209 157739 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2585 73 13 21 17.3 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
CHEMBL4082656 157739 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Antagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assayAntagonist activity at FPR2 in human peripheral blood polymorphonuclear neutrophils assessed as inhibition of WKYMVM-peptide induced ROS production preincubated for 5 mins followed WKYMVM-peptide stimulation by isoluminol/HRP-based chemiluminescence assay
ChEMBL 2585 73 13 21 17.3 CCN(CC)c1ccc2c(-c3ccccc3C(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(=O)N[C@@H](CCCCN)C(=O)N(CCC(N)=O)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)Cc3ccc(C(F)(F)F)cc3)c3ccc(=[N+](CC)CC)cc-3oc2c1 10.1021/acs.jmedchem.7b00489
1048 4054 0 None - 1 Human 10.1 pKd = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10586077
1048 4054 0 None - 1 Human 10.1 pKd = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11035102
1048 4054 0 None - 1 Human 10.1 pKd = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 11285256
1048 4054 0 None - 1 Human 10.1 pKd = 10.1 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 23160941
1022 1656 55 None -38 2 Human 6.4 pKd = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349692
443295 1656 55 None -38 2 Human 6.4 pKd = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349692
CHEMBL267179 1656 55 None -38 2 Human 6.4 pKd = 6.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8349692
1031 423 0 None - 1 Human 6.5 pKd = 6.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12368905
1034 2377 27 None -1 2 Mouse 8.8 pKd = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 9151906
5280914 2377 27 None -1 2 Mouse 8.8 pKd = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 9151906
CHEMBL392438 2377 27 None -1 2 Mouse 8.8 pKd = 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 9151906
1034 2377 27 None 1 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 1322894
1034 2377 27 None 1 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 8006586
5280914 2377 27 None 1 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 1322894
5280914 2377 27 None 1 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 8006586
CHEMBL392438 2377 27 None 1 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 1322894
CHEMBL392438 2377 27 None 1 2 Human 9.0 pKd = 9.0 Binding
UnclassifiedUnclassified
Guide to Pharmacology 352 14 4 4 3.1 CCCCC[C@@H](/C=C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)O)O 8006586
6241 883 0 None - 1 Human 7.3 pKi = 7.3 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 19023040