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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	15931130	108758	0	None	1000	2	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	737	21	6	8	1.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	CHEMBL301477	108758	0	None	1000	2	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	737	21	6	8	1.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	44297866	108821	0	None	38	2	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	723	21	6	8	1.0	CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O	10.1021/jm00169a003
	CHEMBL301841	108821	0	None	38	2	Rat	9.4	pEC50	=	9.4	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	723	21	6	8	1.0	CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O	10.1021/jm00169a003
	2089	9542	28	None	-3	8	Rat	9.3	pEC50	=	9.3	Functional	Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry	ChEMBL		None	None	None		None	10.1021/jm900671k
	3795	9542	28	None	-3	8	Rat	9.3	pEC50	=	9.3	Functional	Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry	ChEMBL		None	None	None		None	10.1021/jm900671k
	5311311	9542	28	None	-3	8	Rat	9.3	pEC50	=	9.3	Functional	Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry	ChEMBL		None	None	None		None	10.1021/jm900671k
	CHEMBL217406	9542	28	None	-3	8	Rat	9.3	pEC50	=	9.3	Functional	Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry	ChEMBL		None	None	None		None	10.1021/jm900671k
	2098	10466	36	None	-63	11	Rat	9.0	pEC50	=	9	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	36511	10466	36	None	-63	11	Rat	9.0	pEC50	=	9	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	3805	10466	36	None	-63	11	Rat	9.0	pEC50	=	9	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	3835	10466	36	None	-63	11	Rat	9.0	pEC50	=	9	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	CHEMBL235363	10466	36	None	-63	11	Rat	9.0	pEC50	=	9	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	44355179	31120	0	None	33	2	Rat	8.9	pEC50	=	8.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	962	30	11	13	-2.2	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL134091	31120	0	None	33	2	Rat	8.9	pEC50	=	8.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	962	30	11	13	-2.2	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O	10.1021/jm00100a027
	2089	9542	28	None	-3	8	Rat	8.8	pEC50	=	8.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	3795	9542	28	None	-3	8	Rat	8.8	pEC50	=	8.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	5311311	9542	28	None	-3	8	Rat	8.8	pEC50	=	8.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	CHEMBL217406	9542	28	None	-3	8	Rat	8.8	pEC50	=	8.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	73356363	96279	0	None	-9	2	Rat	8.0	pEC50	=	8.0	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	711	22	7	8	0.9	CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	CHEMBL2372949	96279	0	None	-9	2	Rat	8.0	pEC50	=	8.0	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	711	22	7	8	0.9	CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	10055612	103200	0	None	-31	3	Rat	5.9	pEC50	=	5.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	711	23	7	8	0.9	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O	10.1021/jm00100a027
	CHEMBL262049	103200	0	None	-31	3	Rat	5.9	pEC50	=	5.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	711	23	7	8	0.9	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O	10.1021/jm00100a027
	10327810	123514	0	None	31	2	Rat	5.9	pEC50	=	5.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763	21	5	8	1.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL337465	123514	0	None	31	2	Rat	5.9	pEC50	=	5.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763	21	5	8	1.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O	10.1021/jm00100a027
	10259515	163916	0	None	-954	2	Rat	4.9	pEC50	=	4.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	751	22	6	8	1.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O	10.1021/jm00100a027
	CHEMBL407511	163916	0	None	-954	2	Rat	4.9	pEC50	=	4.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	751	22	6	8	1.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O	10.1021/jm00100a027
	44355678	30261	0	None	-4	2	Rat	5.9	pEC50	=	5.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	777	21	5	8	2.3	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL133362	30261	0	None	-4	2	Rat	5.9	pEC50	=	5.9	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	777	21	5	8	2.3	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O	10.1021/jm00100a027
	10462850	31035	0	None	36	2	Rat	7.8	pEC50	=	7.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763	21	5	8	1.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL134012	31035	0	None	36	2	Rat	7.8	pEC50	=	7.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763	21	5	8	1.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O	10.1021/jm00100a027
	2098	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	36511	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	3805	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	3835	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	CHEMBL235363	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	2098	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	36511	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	3805	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	3835	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	CHEMBL235363	10466	36	None	-63	11	Rat	6.8	pEC50	=	6.8	Functional	Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae	ChEMBL		None	None	None		None	10.1021/jm00169a003
	73348740	96281	0	None	-51	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	737	21	6	8	1.4	CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	CHEMBL2372953	96281	0	None	-51	2	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	737	21	6	8	1.4	CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	44297675	107396	0	None	47	2	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	711	22	7	8	0.9	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	CHEMBL291903	107396	0	None	47	2	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	711	22	7	8	0.9	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	10395375	123435	0	None	2	2	Rat	5.7	pEC50	=	5.7	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763	21	5	8	1.8	CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL337037	123435	0	None	2	2	Rat	5.7	pEC50	=	5.7	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763	21	5	8	1.8	CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O	10.1021/jm00100a027
	2090	9543	25	None	-6	9	Rat	7.6	pEC50	=	7.6	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	5311312	9543	25	None	-6	9	Rat	7.6	pEC50	=	7.6	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	CHEMBL437797	9543	25	None	-6	9	Rat	7.6	pEC50	=	7.6	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		None	10.1021/jm00100a027
	CHEMBL335054	218259	0	None	20	3	Rat	8.5	pEC50	=	8.5	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O	10.1021/jm00100a027
	5311135	28495	12	None	316	3	Rat	8.4	pEC50	=	8.4	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	920	29	11	13	-2.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL131872	28495	12	None	316	3	Rat	8.4	pEC50	=	8.4	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	920	29	11	13	-2.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL134481	215508	0	None	1	3	Rat	7.5	pEC50	=	7.5	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm00100a027
	44355648	103899	0	None	22	3	Rat	7.4	pEC50	=	7.4	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	994	29	10	13	-1.5	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL267712	103899	0	None	22	3	Rat	7.4	pEC50	=	7.4	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	994	29	10	13	-1.5	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O	10.1021/jm00100a027
	10350201	123939	0	None	6	2	Rat	6.3	pEC50	=	6.3	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763	21	5	8	1.8	CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL339391	123939	0	None	6	2	Rat	6.3	pEC50	=	6.3	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	763	21	5	8	1.8	CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O	10.1021/jm00100a027
	44355117	28560	0	None	19	3	Rat	7.2	pEC50	=	7.2	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	946	28	10	13	-2.1	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL131923	28560	0	None	19	3	Rat	7.2	pEC50	=	7.2	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	946	28	10	13	-2.1	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O	10.1021/jm00100a027
	44297786	108486	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	723	21	6	8	1.0	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O	10.1021/jm00169a003
	CHEMBL299503	108486	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	723	21	6	8	1.0	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O	10.1021/jm00169a003
	44355368	32413	0	None	1	3	Rat	7.2	pEC50	=	7.2	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	737	22	6	8	1.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O	10.1021/jm00100a027
	CHEMBL135186	32413	0	None	1	3	Rat	7.2	pEC50	=	7.2	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	737	22	6	8	1.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O	10.1021/jm00100a027
	2089	9542	28	None	-3	8	Rat	7.2	pEC50	=	7.2	Functional	Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay	ChEMBL		None	None	None		None	10.1021/jm900671k
	3795	9542	28	None	-3	8	Rat	7.2	pEC50	=	7.2	Functional	Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay	ChEMBL		None	None	None		None	10.1021/jm900671k
	5311311	9542	28	None	-3	8	Rat	7.2	pEC50	=	7.2	Functional	Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay	ChEMBL		None	None	None		None	10.1021/jm900671k
	CHEMBL217406	9542	28	None	-3	8	Rat	7.2	pEC50	=	7.2	Functional	Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay	ChEMBL		None	None	None		None	10.1021/jm900671k
	15931129	201757	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	697	22	7	8	0.6	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	CHEMBL54622	201757	0	None	-1	2	Rat	8.2	pEC50	=	8.2	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	697	22	7	8	0.6	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O	10.1021/jm00169a003
	44297852	105783	0	None	7	2	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	763	20	5	8	1.9	CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O	10.1021/jm00169a003
	CHEMBL280020	105783	0	None	7	2	Rat	8.1	pEC50	=	8.1	Functional	Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae	ChEMBL	763	20	5	8	1.9	CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O	10.1021/jm00169a003
	11765601	103199	0	None	9	2	Rat	7.0	pEC50	=	7.0	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	751	22	6	8	1.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O	10.1021/jm00100a027
	CHEMBL262048	103199	0	None	9	2	Rat	7.0	pEC50	=	7.0	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	751	22	6	8	1.8	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O	10.1021/jm00100a027
	10009596	122287	0	None	-1	2	Rat	7.0	pEC50	=	7.0	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	663	22	7	8	0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O	10.1021/jm00100a027
	CHEMBL335248	122287	0	None	-1	2	Rat	7.0	pEC50	=	7.0	Functional	In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.	ChEMBL	663	22	7	8	0.4	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O	10.1021/jm00100a027
	145953024	169369	0	None	-4	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method	ChEMBL	886	20	2	10	3.4	CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC	10.1021/acs.jmedchem.8b00885
	CHEMBL4168948	169369	0	None	-4	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method	ChEMBL	886	20	2	10	3.4	CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC	10.1021/acs.jmedchem.8b00885
	145952624	169164	0	None	-1	4	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method	ChEMBL	889	21	2	10	3.3	CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC	10.1021/acs.jmedchem.8b00885
	CHEMBL4165525	169164	0	None	-1	4	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method	ChEMBL	889	21	2	10	3.3	CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC	10.1021/acs.jmedchem.8b00885
	10917690	214384	1	None	-645	4	Human	5.5	pIC50	=	5.5	Functional	Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2	ChEMBL	471	8	0	5	5.4	COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1016/S0960-894X(97)10097-X
	CHEMBL95051	214384	1	None	-645	4	Human	5.5	pIC50	=	5.5	Functional	Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2	ChEMBL	471	8	0	5	5.4	COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1	10.1016/S0960-894X(97)10097-X
	145957924	168872	0	None	-1	4	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method	ChEMBL	886	20	2	10	3.4	CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC	10.1021/acs.jmedchem.8b00885
	CHEMBL4161021	168872	0	None	-1	4	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method	ChEMBL	886	20	2	10	3.4	CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC	10.1021/acs.jmedchem.8b00885
	CHEMBL412740	219800	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccc(/N=C(\S)Cc2ccccc2)cc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCS)C(N)=O	10.1016/S0960-894X(97)00088-7
	145958767	169034	0	None	1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method	ChEMBL	932	22	2	11	2.8	CC[C@H](C)[C@@H](OC(=O)[C@H](Cc1ccccc1)N(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC	10.1021/acs.jmedchem.8b00885
	CHEMBL4163618	169034	0	None	1	3	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method	ChEMBL	932	22	2	11	2.8	CC[C@H](C)[C@@H](OC(=O)[C@H](Cc1ccccc1)N(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC	10.1021/acs.jmedchem.8b00885
	2089	9542	28	None	-3	8	Human	8.1	pIC50	=	8.1	Functional	Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A	ChEMBL		None	None	None		None	10.1016/S0960-894X(97)00088-7
	3795	9542	28	None	-3	8	Human	8.1	pIC50	=	8.1	Functional	Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A	ChEMBL		None	None	None		None	10.1016/S0960-894X(97)00088-7
	5311311	9542	28	None	-3	8	Human	8.1	pIC50	=	8.1	Functional	Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A	ChEMBL		None	None	None		None	10.1016/S0960-894X(97)00088-7
	CHEMBL217406	9542	28	None	-3	8	Human	8.1	pIC50	=	8.1	Functional	Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A	ChEMBL		None	None	None		None	10.1016/S0960-894X(97)00088-7
	CHEMBL264972	217412	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccc(NC(=S)c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCS)C(N)=O	10.1016/S0960-894X(97)00088-7
	153996	119445	2	None	-2	6	Human	8.1	pIC50	=	8.1	Functional	Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL330366	119445	2	None	-2	6	Human	8.1	pIC50	=	8.1	Functional	Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	CHEMBL539021	119445	2	None	-2	6	Human	8.1	pIC50	=	8.1	Functional	Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10097-X
	44392439	175154	0	None	-	1	Rabbit	10.1	pKd	=	10.1	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	557	7	1	4	5.2	O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL434548	175154	0	None	-	1	Rabbit	10.1	pKd	=	10.1	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	557	7	1	4	5.2	O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
	11433617	13543	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractionsAntagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions	ChEMBL	630	12	2	6	5.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
	CHEMBL1083850	13543	0	None	-	0	Human	9.7	pKd	=	9.7	Functional	Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractionsAntagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions	ChEMBL	630	12	2	6	5.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
	44392392	136951	0	None	-	1	Rabbit	9.7	pKd	=	9.7	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	555	7	0	4	5.4	O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL367815	136951	0	None	-	1	Rabbit	9.7	pKd	=	9.7	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	555	7	0	4	5.4	O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	44392491	175089	0	None	-	1	Rabbit	9.7	pKd	=	9.7	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	556	7	1	4	5.2	NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL434142	175089	0	None	-	1	Rabbit	9.7	pKd	=	9.7	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	556	7	1	4	5.2	NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	44392318	129321	0	None	-	0	Rabbit	9.6	pKd	=	9.6	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	519	7	0	4	5.0	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1	10.1016/j.bmcl.2005.05.134
	CHEMBL360134	129321	0	None	-	0	Rabbit	9.6	pKd	=	9.6	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	519	7	0	4	5.0	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1	10.1016/j.bmcl.2005.05.134
	44346720	121613	0	None	-	0	Golden hamster	9.3	pKd	=	9.3	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	849	14	9	8	1.8	CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL334186	121613	0	None	-	0	Golden hamster	9.3	pKd	=	9.3	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	849	14	9	8	1.8	CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	71452717	85673	0	None	-	0	Rabbit	9.2	pKd	=	9.2	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	678	7	5	6	1.6	O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	CHEMBL2112925	85673	0	None	-	0	Rabbit	9.2	pKd	=	9.2	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	678	7	5	6	1.6	O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	9959481	71993	0	None	-	1	Human	9.2	pKd	=	9.2	Functional	pA2 for NK2 receptor of human bladder IM9 cellspA2 for NK2 receptor of human bladder IM9 cells	ChEMBL	559	7	0	3	6.2	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL182600	71993	0	None	-	1	Human	9.2	pKd	=	9.2	Functional	pA2 for NK2 receptor of human bladder IM9 cellspA2 for NK2 receptor of human bladder IM9 cells	ChEMBL	559	7	0	3	6.2	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
	71449111	85670	0	None	-	0	Rabbit	9.1	pKd	=	9.1	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	759	8	5	6	3.3	O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	CHEMBL2112922	85670	0	None	-	0	Rabbit	9.1	pKd	=	9.1	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	759	8	5	6	3.3	O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	44346727	174947	0	None	-	0	Golden hamster	9.1	pKd	=	9.1	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	784	11	8	7	2.7	CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL433191	174947	0	None	-	0	Golden hamster	9.1	pKd	=	9.1	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	784	11	8	7	2.7	CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44374427	61567	0	None	-	0	Rabbit	9.0	pKd	=	9	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	765	12	6	8	0.9	O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	CHEMBL161242	61567	0	None	-	0	Rabbit	9.0	pKd	=	9	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	765	12	6	8	0.9	O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	71458042	85671	0	None	-	0	Rabbit	9.0	pKd	=	9	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	692	8	5	6	2.0	O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	CHEMBL2112923	85671	0	None	-	0	Rabbit	9.0	pKd	=	9	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	692	8	5	6	2.0	O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	44392351	73176	0	None	-	1	Rabbit	9.0	pKd	=	9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	620	8	0	5	4.3	CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL185182	73176	0	None	-	1	Rabbit	9.0	pKd	=	9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	620	8	0	5	4.3	CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	10929285	73483	0	None	-	1	Rabbit	9.0	pKd	=	9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	507	7	0	4	4.8	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1	10.1016/j.bmcl.2005.05.134
	CHEMBL185572	73483	0	None	-	1	Rabbit	9.0	pKd	=	9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	507	7	0	4	4.8	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1	10.1016/j.bmcl.2005.05.134
	10940813	73105	0	None	-	1	Rabbit	8.9	pKd	=	8.9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	571	9	0	5	2.8	CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL185007	73105	0	None	-	1	Rabbit	8.9	pKd	=	8.9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	571	9	0	5	2.8	CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	44392347	128906	0	None	-	1	Rabbit	8.9	pKd	=	8.9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	543	7	0	4	5.1	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL359655	128906	0	None	-	1	Rabbit	8.9	pKd	=	8.9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	543	7	0	4	5.1	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
	9915372	133837	1	None	-	1	Rabbit	8.9	pKd	=	8.9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	543	8	1	5	2.2	NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL365613	133837	1	None	-	1	Rabbit	8.9	pKd	=	8.9	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	543	8	1	5	2.2	NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	9915372	133837	1	None	-	1	Human	8.8	pKd	=	8.8	Functional	pA2 for NK2 receptor of Human bladderpA2 for NK2 receptor of Human bladder	ChEMBL	543	8	1	5	2.2	NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL365613	133837	1	None	-	1	Human	8.8	pKd	=	8.8	Functional	pA2 for NK2 receptor of Human bladderpA2 for NK2 receptor of Human bladder	ChEMBL	543	8	1	5	2.2	NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	44392445	73129	0	None	-	1	Rabbit	8.8	pKd	=	8.8	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	495	8	0	3	5.2	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL185133	73129	0	None	-	1	Rabbit	8.8	pKd	=	8.8	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	495	8	0	3	5.2	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1	10.1016/j.bmcl.2005.05.134
	44346794	22040	0	None	-	0	Golden hamster	8.8	pKd	=	8.8	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	828	11	8	7	3.1	CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL121271	22040	0	None	-	0	Golden hamster	8.8	pKd	=	8.8	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	828	11	8	7	3.1	CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	10972666	129724	0	None	-	1	Rabbit	8.7	pKd	=	8.7	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	465	7	0	4	3.7	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL360721	129724	0	None	-	1	Rabbit	8.7	pKd	=	8.7	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	465	7	0	4	3.7	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1	10.1016/j.bmcl.2005.05.134
	10950925	136432	0	None	-	1	Rabbit	8.7	pKd	=	8.7	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	478	7	1	4	3.8	NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL367348	136432	0	None	-	1	Rabbit	8.7	pKd	=	8.7	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	478	7	1	4	3.8	NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	9830361	188405	0	None	-	0	Human	8.0	pKd	=	8	Functional	Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2	ChEMBL	538	7	1	4	7.1	C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
	CHEMBL47739	188405	0	None	-	0	Human	8.0	pKd	=	8	Functional	Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2	ChEMBL	538	7	1	4	7.1	C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
	10232566	10990	0	None	-	0	Human	8.0	pKd	=	8	Functional	Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2	ChEMBL	607	12	2	4	6.1	CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
	CHEMBL100297	10990	0	None	-	0	Human	8.0	pKd	=	8	Functional	Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2	ChEMBL	607	12	2	4	6.1	CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
	44307677	176043	0	None	-	0	Guinea pig	8.0	pKd	=	8	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL441252	176043	0	None	-	0	Guinea pig	8.0	pKd	=	8	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	44370530	55897	0	None	-	0	Rat	7.0	pKd	=	7	Functional	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	639	13	4	7	2.6	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	10.1021/jm960213s
	CHEMBL156186	55897	0	None	-	0	Rat	7.0	pKd	=	7	Functional	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	639	13	4	7	2.6	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	10.1021/jm960213s
	9810288	210470	0	None	-	0	Guinea pig	7.0	pKd	=	7	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL67508	210470	0	None	-	0	Guinea pig	7.0	pKd	=	7	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	44346881	148301	0	None	-	0	Golden hamster	7.0	pKd	=	7	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	923	13	9	9	1.5	CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O	10.1021/jm00047a020
	CHEMBL384610	148301	0	None	-	0	Golden hamster	7.0	pKd	=	7	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	923	13	9	9	1.5	CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O	10.1021/jm00047a020
	10350528	113510	0	None	-	4	Rabbit	5.0	pKd	=	5	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	831	18	4	9	4.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL3144210	113510	0	None	-	4	Rabbit	5.0	pKd	=	5	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	831	18	4	9	4.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	10439730	113534	0	None	-	4	Rabbit	5.0	pKd	=	5	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	702	12	3	6	3.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL3144353	113534	0	None	-	4	Rabbit	5.0	pKd	=	5	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	702	12	3	6	3.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL413730	219864	0	None	-	0	Golden hamster	4.0	pKd	=	4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		None	10.1021/jm00014a022
	CHEMBL217365	216153	0	None	-	0	Rabbit	4.0	pKd	=	4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL262647	217322	0	None	-	0	Rabbit	4.0	pKd	=	4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O	10.1021/jm00014a022
	CHEMBL263985	217379	0	None	-	0	Rabbit	4.0	pKd	=	4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL329888	218101	0	None	-	0	Rabbit	4.0	pKd	=	4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O	10.1021/jm00014a022
	CHEMBL412621	219789	0	None	-	0	Rabbit	4.0	pKd	=	4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O	10.1021/jm00014a022
	CHEMBL413730	219864	0	None	-	0	Rabbit	4.0	pKd	=	4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		None	10.1021/jm00014a022
	44346487	120907	0	None	-	0	Rabbit	6.0	pKd	=	6.0	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	746	11	9	8	0.2	CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL332872	120907	0	None	-	0	Rabbit	6.0	pKd	=	6.0	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	746	11	9	8	0.2	CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44346706	174948	0	None	-	0	Golden hamster	7.0	pKd	=	7.0	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	745	11	9	8	-0.4	CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL433192	174948	0	None	-	0	Golden hamster	7.0	pKd	=	7.0	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	745	11	9	8	-0.4	CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL406487	219389	0	None	-	0	Golden hamster	6.0	pKd	=	6.0	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	44347003	170957	0	None	-	0	Rabbit	7.0	pKd	=	7.0	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	744	11	8	7	1.7	CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm00047a020
	CHEMBL421062	170957	0	None	-	0	Rabbit	7.0	pKd	=	7.0	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	744	11	8	7	1.7	CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm00047a020
	CHEMBL216897	216123	0	None	-	0	Golden hamster	5.0	pKd	=	5.0	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	44346707	121273	0	None	-	0	Rabbit	6.9	pKd	=	6.9	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	798	11	7	7	3.0	CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL333515	121273	0	None	-	0	Rabbit	6.9	pKd	=	6.9	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	798	11	7	7	3.0	CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL407328	219433	0	None	-	0	Golden hamster	5.9	pKd	=	5.9	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	44307898	208252	0	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL60504	208252	0	None	-	0	Guinea pig	7.9	pKd	=	7.9	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	44347083	22226	0	None	-	0	Golden hamster	7.9	pKd	=	7.9	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	762	12	8	8	1.4	CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm00047a020
	CHEMBL121571	22226	0	None	-	0	Golden hamster	7.9	pKd	=	7.9	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	762	12	8	8	1.4	CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm00047a020
	CHEMBL385603	219136	0	None	-	0	Golden hamster	5.9	pKd	=	5.9	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	44307821	108891	0	None	-	0	Guinea pig	6.9	pKd	=	6.9	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL302329	108891	0	None	-	0	Guinea pig	6.9	pKd	=	6.9	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	10259370	113525	0	None	-	0	Rabbit	6.9	pKd	=	6.9	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	730	12	3	7	3.4	CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21	10.1021/jm00063a015
	CHEMBL3144340	113525	0	None	-	0	Rabbit	6.9	pKd	=	6.9	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	730	12	3	7	3.4	CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21	10.1021/jm00063a015
	CHEMBL412189	219754	0	None	-	0	Rabbit	5.9	pKd	=	5.9	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm00014a022
	10418001	113530	0	None	-	0	Rabbit	5.9	pKd	=	5.9	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	822	14	3	8	4.9	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL3144348	113530	0	None	-	0	Rabbit	5.9	pKd	=	5.9	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	822	14	3	8	4.9	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	10349900	113526	0	None	-	4	Rabbit	4.9	pKd	=	4.9	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	716	13	3	7	2.8	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL3144343	113526	0	None	-	4	Rabbit	4.9	pKd	=	4.9	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	716	13	3	7	2.8	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	10395494	113531	0	None	-	0	Rabbit	4.9	pKd	=	4.9	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	788	12	3	8	4.5	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL3144349	113531	0	None	-	0	Rabbit	4.9	pKd	=	4.9	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	788	12	3	8	4.5	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	44347084	121030	0	None	-	0	Rabbit	6.9	pKd	=	6.9	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	893	16	9	9	2.8	CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL333027	121030	0	None	-	0	Rabbit	6.9	pKd	=	6.9	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	893	16	9	9	2.8	CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44346863	173163	0	None	-	0	Rabbit	6.9	pKd	=	6.9	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	909	13	9	9	2.0	CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL427606	173163	0	None	-	0	Rabbit	6.9	pKd	=	6.9	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	909	13	9	9	2.0	CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL263743	217367	0	None	-	0	Rabbit	4.9	pKd	=	4.9	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		None	10.1021/jm00014a022
	CHEMBL385914	219148	0	None	-	0	Rabbit	5.9	pKd	=	5.9	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O	10.1021/jm00014a022
	CHEMBL439287	220611	0	None	-	0	Golden hamster	5.9	pKd	=	5.9	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O	10.1021/jm00014a022
	CHEMBL267409	217499	0	None	-	0	Golden hamster	6.9	pKd	=	6.9	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O	10.1021/jm00014a022
	CHEMBL329888	218101	0	None	-	0	Rat	4.9	pKd	=	4.9	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O	10.1021/jm00014a022
	CHEMBL387199	219186	0	None	-	0	Golden hamster	5.8	pKd	=	5.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	44346488	170967	0	None	-	0	Rabbit	5.8	pKd	=	5.8	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	798	11	8	7	2.2	CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O	10.1021/jm00047a020
	CHEMBL421071	170967	0	None	-	0	Rabbit	5.8	pKd	=	5.8	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	798	11	8	7	2.2	CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O	10.1021/jm00047a020
	CHEMBL267409	217499	0	None	-	0	Rabbit	5.8	pKd	=	5.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O	10.1021/jm00014a022
	CHEMBL329888	218101	0	None	-	0	Golden hamster	4.8	pKd	=	4.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O	10.1021/jm00014a022
	44346720	121613	0	None	-	0	Rabbit	7.8	pKd	=	7.8	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	849	14	9	8	1.8	CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL334186	121613	0	None	-	0	Rabbit	7.8	pKd	=	7.8	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	849	14	9	8	1.8	CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44307679	210296	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
	CHEMBL66332	210296	0	None	-	0	Guinea pig	7.8	pKd	=	7.8	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
	44347003	170957	0	None	-	0	Golden hamster	7.8	pKd	=	7.8	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	744	11	8	7	1.7	CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm00047a020
	CHEMBL421062	170957	0	None	-	0	Golden hamster	7.8	pKd	=	7.8	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	744	11	8	7	1.7	CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm00047a020
	CHEMBL439287	220611	0	None	-	0	Rat	6.8	pKd	=	6.8	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O	10.1021/jm00014a022
	CHEMBL217365	216153	0	None	-	0	Golden hamster	4.8	pKd	=	4.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	44307773	109137	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	779	13	0	7	7.6	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL303803	109137	0	None	-	0	Guinea pig	6.8	pKd	=	6.8	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	779	13	0	7	7.6	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL429340	220301	0	None	-	0	Golden hamster	5.8	pKd	=	5.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL439284	220610	22	None	-	0	Rabbit	5.8	pKd	=	5.8	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O	10.1021/jm00063a015
	10395612	113524	0	None	-	0	Rabbit	4.8	pKd	=	4.8	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	814	18	3	7	5.7	CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21	10.1021/jm00063a015
	CHEMBL3144339	113524	0	None	-	0	Rabbit	4.8	pKd	=	4.8	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	814	18	3	7	5.7	CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21	10.1021/jm00063a015
	10032981	113529	0	None	-	0	Rabbit	4.8	pKd	=	4.8	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	746	12	3	8	3.3	COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21	10.1021/jm00063a015
	CHEMBL3144347	113529	0	None	-	0	Rabbit	4.8	pKd	=	4.8	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	746	12	3	8	3.3	COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21	10.1021/jm00063a015
	9832198	113532	0	None	-	4	Rabbit	4.8	pKd	=	4.8	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	788	15	4	8	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL3144351	113532	0	None	-	4	Rabbit	4.8	pKd	=	4.8	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	788	15	4	8	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL385603	219136	0	None	-	0	Rabbit	5.8	pKd	=	5.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	CHEMBL439287	220611	0	None	-	0	Rabbit	5.8	pKd	=	5.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O	10.1021/jm00014a022
	CHEMBL268563	217538	0	None	-	0	Rabbit	5.8	pKd	=	5.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm00014a022
	CHEMBL268563	217538	0	None	-	0	Golden hamster	5.8	pKd	=	5.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm00014a022
	CHEMBL412621	219789	0	None	-	0	Golden hamster	5.8	pKd	=	5.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O	10.1021/jm00014a022
	CHEMBL263743	217367	0	None	-	0	Golden hamster	4.8	pKd	=	4.8	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		None	10.1021/jm00014a022
	44347002	119611	0	None	-	0	Golden hamster	7.7	pKd	=	7.7	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	778	11	8	7	1.9	CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL330810	119611	0	None	-	0	Golden hamster	7.7	pKd	=	7.7	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	778	11	8	7	1.9	CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL438716	220567	0	None	-	0	Rat	4.7	pKd	=	4.7	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	9874206	210550	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL68060	210550	0	None	-	0	Guinea pig	7.7	pKd	=	7.7	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL412621	219789	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O	10.1021/jm00014a022
	CHEMBL263997	217380	0	None	-	0	Rabbit	6.7	pKd	=	6.7	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL441181	220660	0	None	-	0	Rat	5.7	pKd	=	5.7	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	CHEMBL438716	220567	0	None	-	0	Rabbit	4.7	pKd	=	4.7	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	57391133	75142	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay	ChEMBL	691	12	3	7	4.4	COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1	10.1016/j.ejmech.2011.08.042
	CHEMBL1916635	75142	0	None	-	0	Human	6.7	pKd	=	6.7	Functional	Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay	ChEMBL	691	12	3	7	4.4	COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1	10.1016/j.ejmech.2011.08.042
	44370713	57806	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	653	13	4	7	3.2	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O	10.1021/jm960213s
	CHEMBL157858	57806	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	653	13	4	7	3.2	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O	10.1021/jm960213s
	10055415	113533	0	None	-	4	Rabbit	5.7	pKd	=	5.7	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	688	12	4	5	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL3144352	113533	0	None	-	4	Rabbit	5.7	pKd	=	5.7	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	688	12	4	5	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	3086681	9052	17	None	-	1	Rabbit	4.7	pKd	=	4.7	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	559	11	2	5	4.2	COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1	10.1021/jm950616c
	3510	9052	17	None	-	1	Rabbit	4.7	pKd	=	4.7	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	559	11	2	5	4.2	COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1	10.1021/jm950616c
	CHEMBL42407	9052	17	None	-	1	Rabbit	4.7	pKd	=	4.7	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	559	11	2	5	4.2	COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1	10.1021/jm950616c
	10325464	126912	0	None	-	1	Rabbit	4.7	pKd	=	4.7	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	559	11	2	5	4.2	COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O	10.1021/jm950616c
	CHEMBL351236	126912	0	None	-	1	Rabbit	4.7	pKd	=	4.7	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	559	11	2	5	4.2	COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O	10.1021/jm950616c
	10506928	126996	0	None	-	1	Rabbit	4.7	pKd	=	4.7	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	553	11	2	5	4.1	COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O	10.1021/jm950616c
	CHEMBL352102	126996	0	None	-	1	Rabbit	4.7	pKd	=	4.7	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	553	11	2	5	4.1	COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O	10.1021/jm950616c
	10350454	113508	0	None	-	4	Rabbit	4.7	pKd	=	4.7	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	815	18	4	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	CHEMBL3144209	113508	0	None	-	4	Rabbit	4.7	pKd	=	4.7	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	815	18	4	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
	44347001	119961	0	None	-	0	Golden hamster	8.7	pKd	=	8.7	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	851	15	9	9	2.0	CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL331480	119961	0	None	-	0	Golden hamster	8.7	pKd	=	8.7	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	851	15	9	9	2.0	CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44374556	59505	0	None	-	0	Rabbit	8.6	pKd	=	8.6	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	773	9	5	6	3.7	O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	CHEMBL159449	59505	0	None	-	0	Rabbit	8.6	pKd	=	8.6	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	773	9	5	6	3.7	O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	44392444	129112	0	None	-	1	Rabbit	8.6	pKd	=	8.6	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	481	7	0	3	4.8	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL359903	129112	0	None	-	1	Rabbit	8.6	pKd	=	8.6	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	481	7	0	3	4.8	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL429340	220301	0	None	-	0	Rabbit	7.7	pKd	=	7.7	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL263997	217380	0	None	-	0	Rat	6.7	pKd	=	6.7	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	44347083	22226	0	None	-	0	Rabbit	6.7	pKd	=	6.7	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	762	12	8	8	1.4	CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm00047a020
	CHEMBL121571	22226	0	None	-	0	Rabbit	6.7	pKd	=	6.7	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	762	12	8	8	1.4	CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O	10.1021/jm00047a020
	CHEMBL334721	218178	1	None	-	2	Guinea pig	7.6	pKd	=	7.6	Functional	Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig tracheaCompound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig trachea	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1016/s0960-894x(98)00282-0
	CHEMBL263985	217379	0	None	-	0	Rat	5.6	pKd	=	5.6	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	9918520	109528	0	None	-	0	Guinea pig	7.6	pKd	=	7.6	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL305055	109528	0	None	-	0	Guinea pig	7.6	pKd	=	7.6	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL429340	220301	0	None	-	0	Rat	6.6	pKd	=	6.6	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL217365	216153	0	None	-	0	Rat	4.6	pKd	=	4.6	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL266526	217465	0	None	-	0	Rabbit	6.6	pKd	=	6.6	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL412830	219810	0	None	-	0	Rabbit	5.6	pKd	=	5.6	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O	10.1021/jm00014a022
	CHEMBL412189	219754	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm00014a022
	CHEMBL385914	219148	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O	10.1021/jm00014a022
	71449112	85674	0	None	-	0	Rabbit	8.5	pKd	=	8.5	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	682	10	8	7	0.3	O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	CHEMBL2112926	85674	0	None	-	0	Rabbit	8.5	pKd	=	8.5	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	682	10	8	7	0.3	O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	44374557	126373	0	None	-	0	Rabbit	8.5	pKd	=	8.5	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	693	11	6	6	1.9	CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1016/s0960-894x(01)00841-1
	CHEMBL346285	126373	0	None	-	0	Rabbit	8.5	pKd	=	8.5	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	693	11	6	6	1.9	CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1016/s0960-894x(01)00841-1
	9807403	73458	0	None	-	1	Rabbit	8.5	pKd	=	8.5	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	542	8	0	5	2.9	CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL185452	73458	0	None	-	1	Rabbit	8.5	pKd	=	8.5	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	542	8	0	5	2.9	CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	44346707	121273	0	None	-	0	Golden hamster	8.4	pKd	=	8.4	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	798	11	7	7	3.0	CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL333515	121273	0	None	-	0	Golden hamster	8.4	pKd	=	8.4	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	798	11	7	7	3.0	CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44370529	55833	0	None	-	0	Rat	8.4	pKd	=	8.4	Functional	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	643	10	3	7	3.0	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O	10.1021/jm960213s
	CHEMBL156128	55833	0	None	-	0	Rat	8.4	pKd	=	8.4	Functional	Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)	ChEMBL	643	10	3	7	3.0	CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O	10.1021/jm960213s
	10305816	10991	1	None	-	0	Human	8.4	pKd	=	8.4	Functional	Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2	ChEMBL	736	16	2	6	6.9	O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
	CHEMBL100298	10991	1	None	-	0	Human	8.4	pKd	=	8.4	Functional	Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2	ChEMBL	736	16	2	6	6.9	O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
	44374543	59669	0	None	-	0	Rabbit	8.4	pKd	=	8.4	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	773	9	5	6	3.7	O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	CHEMBL159585	59669	0	None	-	0	Rabbit	8.4	pKd	=	8.4	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	773	9	5	6	3.7	O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
	44374598	126269	0	None	-	0	Rabbit	8.4	pKd	=	8.4	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	811	10	10	10	-1.2	CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
	CHEMBL345402	126269	0	None	-	0	Rabbit	8.4	pKd	=	8.4	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	811	10	10	10	-1.2	CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
	CHEMBL412830	219810	0	None	-	0	Rat	7.5	pKd	=	7.5	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O	10.1021/jm00014a022
	44346486	120900	0	None	-	0	Golden hamster	6.5	pKd	=	6.5	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	759	13	9	8	0.8	CC(C)C[C@@H]1CN[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL332820	120900	0	None	-	0	Golden hamster	6.5	pKd	=	6.5	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	759	13	9	8	0.8	CC(C)C[C@@H]1CN[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44346488	170967	0	None	-	0	Golden hamster	7.5	pKd	=	7.5	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	798	11	8	7	2.2	CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O	10.1021/jm00047a020
	CHEMBL421071	170967	0	None	-	0	Golden hamster	7.5	pKd	=	7.5	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	798	11	8	7	2.2	CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O	10.1021/jm00047a020
	10145229	15945	0	None	-	0	Golden hamster	6.5	pKd	=	6.5	Functional	Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.	ChEMBL	592	7	1	4	5.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
	CHEMBL110219	15945	0	None	-	0	Golden hamster	6.5	pKd	=	6.5	Functional	Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.	ChEMBL	592	7	1	4	5.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
	CHEMBL263985	217379	0	None	-	0	Golden hamster	4.5	pKd	=	4.5	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	44305816	169798	0	None	-	0	Rabbit	4.5	pKd	=	4.5	Functional	Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.	ChEMBL	589	8	2	4	3.6	CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21	10.1016/S0960-894X(96)00604-X
	CHEMBL417572	169798	0	None	-	0	Rabbit	4.5	pKd	=	4.5	Functional	Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.	ChEMBL	589	8	2	4	3.6	CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21	10.1016/S0960-894X(96)00604-X
	CHEMBL216897	216123	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL267409	217499	0	None	-	0	Rat	7.5	pKd	=	7.5	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O	10.1021/jm00014a022
	CHEMBL407328	219433	0	None	-	0	Rat	6.5	pKd	=	6.5	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL385914	219148	0	None	-	0	Golden hamster	6.5	pKd	=	6.5	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O	10.1021/jm00014a022
	44346727	174947	0	None	-	0	Rabbit	7.4	pKd	=	7.4	Functional	Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uMTested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM	ChEMBL	784	11	8	7	2.7	CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL433191	174947	0	None	-	0	Rabbit	7.4	pKd	=	7.4	Functional	Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uMTested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM	ChEMBL	784	11	8	7	2.7	CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL266526	217465	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL387199	219186	0	None	-	0	Rat	6.4	pKd	=	6.4	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	44307819	109373	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL304106	109373	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	44307678	205454	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
	CHEMBL57993	205454	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
	44307820	210414	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL67171	210414	0	None	-	0	Guinea pig	7.4	pKd	=	7.4	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	21121353	108250	0	None	-	4	Rabbit	5.4	pKd	=	5.4	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	625	14	4	7	2.0	CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	10.1021/jm00063a015
	CHEMBL297776	108250	0	None	-	4	Rabbit	5.4	pKd	=	5.4	Functional	Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist	ChEMBL	625	14	4	7	2.0	CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	10.1021/jm00063a015
	44346863	173163	0	None	-	0	Golden hamster	8.4	pKd	=	8.4	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	909	13	9	9	2.0	CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL427606	173163	0	None	-	0	Golden hamster	8.4	pKd	=	8.4	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	909	13	9	9	2.0	CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL406487	219389	0	None	-	0	Rabbit	6.4	pKd	=	6.4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL262647	217322	0	None	-	0	Golden hamster	5.4	pKd	=	5.4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O	10.1021/jm00014a022
	44346794	22040	0	None	-	0	Rabbit	7.4	pKd	=	7.4	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	828	11	8	7	3.1	CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL121271	22040	0	None	-	0	Rabbit	7.4	pKd	=	7.4	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	828	11	8	7	3.1	CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL412830	219810	0	None	-	0	Golden hamster	6.4	pKd	=	6.4	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O	10.1021/jm00014a022
	CHEMBL263743	217367	0	None	-	0	Rat	5.4	pKd	=	5.4	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		None	10.1021/jm00014a022
	CHEMBL441181	220660	0	None	-	0	Rabbit	5.3	pKd	=	5.3	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	9829402	175279	0	None	-	0	Rabbit	8.3	pKd	=	8.3	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1016/s0960-894x(01)00841-1
	CHEMBL435324	175279	0	None	-	0	Rabbit	8.3	pKd	=	8.3	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1016/s0960-894x(01)00841-1
	1488931	58335	15	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig tracheaCompound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea	ChEMBL	344	2	0	6	3.8	O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12	10.1016/0960-894X(95)00558-B
	CHEMBL158318	58335	15	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig tracheaCompound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea	ChEMBL	344	2	0	6	3.8	O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12	10.1016/0960-894X(95)00558-B
	9896563	110557	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
	CHEMBL308891	110557	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
	9939307	210265	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL66106	210265	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	44307757	210315	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL66441	210315	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	44307758	210335	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL66635	210335	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	9810835	210354	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL66763	210354	0	None	-	0	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	44307741	210566	0	None	-	0	Guinea pig	6.3	pKd	=	6.3	Functional	In vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstrictionIn vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstriction	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL68234	210566	0	None	-	0	Guinea pig	6.3	pKd	=	6.3	Functional	In vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstrictionIn vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstriction	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	104943	62160	39	None	-	4	Rabbit	4.3	pKd	=	4.3	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	412	7	1	3	5.1	COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1	10.1021/jm950616c
	CHEMBL16192	62160	39	None	-	4	Rabbit	4.3	pKd	=	4.3	Functional	Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2	ChEMBL	412	7	1	3	5.1	COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1	10.1021/jm950616c
	44347001	119961	0	None	-	0	Rabbit	7.3	pKd	=	7.3	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	851	15	9	9	2.0	CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL331480	119961	0	None	-	0	Rabbit	7.3	pKd	=	7.3	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	851	15	9	9	2.0	CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	9939040	11782	7	None	-	2	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
	CHEMBL105060	11782	7	None	-	2	Guinea pig	7.3	pKd	=	7.3	Functional	In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
	CHEMBL266526	217465	0	None	-	0	Golden hamster	6.3	pKd	=	6.3	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL327457	218072	0	None	-	0	Rabbit	5.2	pKd	=	5.2	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O	10.1021/jm00014a022
	CHEMBL334721	218178	1	None	-	2	Rat	8.2	pKd	=	8.2	Functional	Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferensCompound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferens	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1016/s0960-894x(98)00282-0
	44374504	61623	0	None	-	0	Rabbit	8.2	pKd	=	8.2	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	825	11	10	10	-0.8	CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
	CHEMBL161288	61623	0	None	-	0	Rabbit	8.2	pKd	=	8.2	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	825	11	10	10	-0.8	CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
	71461644	85672	0	None	-	0	Rabbit	8.2	pKd	=	8.2	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	784	10	10	10	-0.9	O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O	10.1016/s0960-894x(01)00841-1
	CHEMBL2112924	85672	0	None	-	0	Rabbit	8.2	pKd	=	8.2	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	784	10	10	10	-0.9	O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O	10.1016/s0960-894x(01)00841-1
	11038500	70327	0	None	-	1	Rabbit	8.2	pKd	=	8.2	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	507	9	0	4	4.8	CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	CHEMBL180049	70327	0	None	-	1	Rabbit	8.2	pKd	=	8.2	Functional	pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery	ChEMBL	507	9	0	4	4.8	CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
	44347084	121030	0	None	-	0	Golden hamster	8.2	pKd	=	8.2	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	893	16	9	9	2.8	CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL333027	121030	0	None	-	0	Golden hamster	8.2	pKd	=	8.2	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	893	16	9	9	2.8	CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	9875181	178122	0	None	-	0	Guinea pig	7.2	pKd	=	7.2	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL446146	178122	0	None	-	0	Guinea pig	7.2	pKd	=	7.2	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	57391132	75141	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay	ChEMBL	599	10	3	6	2.6	COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1	10.1016/j.ejmech.2011.08.042
	CHEMBL1916634	75141	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay	ChEMBL	599	10	3	6	2.6	COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1	10.1016/j.ejmech.2011.08.042
	44307953	175973	0	None	-	0	Guinea pig	6.2	pKd	=	6.2	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	784	12	1	7	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL440679	175973	0	None	-	0	Guinea pig	6.2	pKd	=	6.2	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	784	12	1	7	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL540651	175973	0	None	-	0	Guinea pig	6.2	pKd	=	6.2	Functional	In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction	ChEMBL	784	12	1	7	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
	CHEMBL438716	220567	0	None	-	0	Golden hamster	5.2	pKd	=	5.2	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL216897	216123	0	None	-	0	Rabbit	5.2	pKd	=	5.2	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	132837	9018	55	None	-	4	Rabbit	5.2	pKd	=	5.2	Functional	Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1016/S0960-894X(96)00604-X
	9461	9018	55	None	-	4	Rabbit	5.2	pKd	=	5.2	Functional	Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1016/S0960-894X(96)00604-X
	CHEMBL22870	9018	55	None	-	4	Rabbit	5.2	pKd	=	5.2	Functional	Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1016/S0960-894X(96)00604-X
	CHEMBL407328	219433	0	None	-	0	Rabbit	7.2	pKd	=	7.2	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL263997	217380	0	None	-	0	Golden hamster	6.2	pKd	=	6.2	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL441181	220660	0	None	-	0	Golden hamster	5.2	pKd	=	5.2	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	44346487	120907	0	None	-	0	Golden hamster	7.2	pKd	=	7.2	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	746	11	9	8	0.2	CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL332872	120907	0	None	-	0	Golden hamster	7.2	pKd	=	7.2	Functional	Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea	ChEMBL	746	11	9	8	0.2	CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44346706	174948	0	None	-	0	Rabbit	6.2	pKd	=	6.2	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	745	11	9	8	-0.4	CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL433192	174948	0	None	-	0	Rabbit	6.2	pKd	=	6.2	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	745	11	9	8	-0.4	CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44374622	126841	0	None	-	0	Rabbit	8.1	pKd	=	8.1	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	825	11	10	10	-0.8	CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
	CHEMBL350596	126841	0	None	-	0	Rabbit	8.1	pKd	=	8.1	Functional	In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)	ChEMBL	825	11	10	10	-0.8	CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
	CHEMBL327457	218072	0	None	-	0	Rat	5.1	pKd	=	5.1	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O	10.1021/jm00014a022
	CHEMBL385603	219136	0	None	-	0	Rat	7.1	pKd	=	7.1	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	44347002	119611	0	None	-	0	Rabbit	7.1	pKd	=	7.1	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	778	11	8	7	1.9	CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	CHEMBL330810	119611	0	None	-	0	Rabbit	7.1	pKd	=	7.1	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	778	11	8	7	1.9	CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1	10.1021/jm00047a020
	44346881	148301	0	None	-	0	Rabbit	5.1	pKd	=	5.1	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	923	13	9	9	1.5	CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O	10.1021/jm00047a020
	CHEMBL384610	148301	0	None	-	0	Rabbit	5.1	pKd	=	5.1	Functional	Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery	ChEMBL	923	13	9	9	1.5	CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O	10.1021/jm00047a020
	CHEMBL406487	219389	0	None	-	0	Rat	6.1	pKd	=	6.1	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O	10.1021/jm00014a022
	CHEMBL387199	219186	0	None	-	0	Rabbit	7.1	pKd	=	7.1	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/jm00014a022
	CHEMBL327457	218072	0	None	-	0	Golden hamster	5.0	pKd	=	5.0	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O	10.1021/jm00014a022
	CHEMBL412189	219754	0	None	-	0	Golden hamster	6.0	pKd	=	6.0	Functional	Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.	ChEMBL		None	None	None		CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1021/jm00014a022
	CHEMBL413730	219864	0	None	-	0	Rat	5.0	pKd	=	5.0	Functional	Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)	ChEMBL		None	None	None		None	10.1021/jm00014a022
	44434204	160347	0	None	-	0	Guinea pig	7.0	pKi	=	7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	610	11	3	6	3.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	CHEMBL398028	160347	0	None	-	0	Guinea pig	7.0	pKi	=	7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	610	11	3	6	3.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	10166998	173460	0	None	-	0	Guinea pig	7.0	pKi	=	7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	576	11	3	6	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	CHEMBL428203	173460	0	None	-	0	Guinea pig	7.0	pKi	=	7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	576	11	3	6	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	44434205	96177	0	None	-	0	Guinea pig	6.9	pKi	=	6.9	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	623	11	3	6	3.7	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1	10.1016/j.bmcl.2007.06.053
	CHEMBL237048	96177	0	None	-	0	Guinea pig	6.9	pKi	=	6.9	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	623	11	3	6	3.7	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1	10.1016/j.bmcl.2007.06.053
	44434197	156005	0	None	-	0	Guinea pig	7.7	pKi	=	7.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	610	11	3	6	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	CHEMBL394419	156005	0	None	-	0	Guinea pig	7.7	pKi	=	7.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	610	11	3	6	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	10121831	96214	0	None	-	0	Guinea pig	6.7	pKi	=	6.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	618	17	3	5	6.5	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
	CHEMBL237097	96214	0	None	-	0	Guinea pig	6.7	pKi	=	6.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	618	17	3	5	6.5	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
	44434203	156006	0	None	-	0	Guinea pig	6.7	pKi	=	6.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	594	11	3	5	4.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	CHEMBL394420	156006	0	None	-	0	Guinea pig	6.7	pKi	=	6.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	594	11	3	5	4.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	44434191	156615	0	None	-	0	Guinea pig	6.7	pKi	=	6.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	588	11	3	5	5.4	CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
	CHEMBL394889	156615	0	None	-	0	Guinea pig	6.7	pKi	=	6.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	588	11	3	5	5.4	CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
	44434202	158949	0	None	-	0	Guinea pig	6.7	pKi	=	6.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	652	17	3	5	6.3	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1	10.1016/j.bmcl.2007.06.053
	CHEMBL396827	158949	0	None	-	0	Guinea pig	6.7	pKi	=	6.7	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	652	17	3	5	6.3	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1	10.1016/j.bmcl.2007.06.053
	10281234	99009	0	None	-	0	Guinea pig	7.6	pKi	=	7.6	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	562	11	3	6	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	CHEMBL242631	99009	0	None	-	0	Guinea pig	7.6	pKi	=	7.6	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	562	11	3	6	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
	44434198	156602	0	None	-	0	Guinea pig	7.6	pKi	=	7.6	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	623	11	3	6	4.0	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1	10.1016/j.bmcl.2007.06.053
	CHEMBL394878	156602	0	None	-	0	Guinea pig	7.6	pKi	=	7.6	Functional	Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle	ChEMBL	623	11	3	6	4.0	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1	10.1016/j.bmcl.2007.06.053
	3881	8635	0	None	-	1	Rat	8.4	pEC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	1331460
	2091	9571	0	None	223	2	Guinea pig	8.8	pEC50	=	8.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	1311427
	2089	9542	28	None	-1	8	Guinea pig	8.9	pEC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	2426129
	3795	9542	28	None	-1	8	Guinea pig	8.9	pEC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	2426129
	5311311	9542	28	None	-1	8	Guinea pig	8.9	pEC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	2426129
	CHEMBL217406	9542	28	None	-1	8	Guinea pig	8.9	pEC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	2426129
	16132172	9568	0	None	-	1	Guinea pig	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	1311427
	3667	9568	0	None	-	1	Guinea pig	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	1311427
	30699	224483	0	None	-1	14	Human	8.3	pIC50	=	8.3	Functional	NoneNone	Drug Central	423	7	2	8	0.5	CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O	None
	104974	10248	31	None	6	5	Guinea pig	10.3	pIC50	=	10.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1334836
	2111	10248	31	None	6	5	Guinea pig	10.3	pIC50	=	10.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1334836
	3481	10248	31	None	6	5	Guinea pig	10.3	pIC50	=	10.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1334836
	CHEMBL308148	10248	31	None	6	5	Guinea pig	10.3	pIC50	=	10.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1334836
	DB06660	10248	31	None	6	5	Guinea pig	10.3	pIC50	=	10.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1334836
	3843	9215	0	None	-	1	Rat	9.1	pIC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9718274

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		1024	8072	71	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		162639143	8072	71	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		5284373	8072	71	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		760	8072	71	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		CHEMBL160	8072	71	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		DB00091	8072	71	None	-	1	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		CHEMBL3039583	217728	0	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration	ChEMBL		None	None	None		NCCCC[C@@H]1NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](c2ccccc2)NC(=O)[C@@H]2C[C@H](OC(=O)NCCN)CN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccc(OCc3ccccc3)cc2)NC1=O	10.1038/s41467-023-40064-9
		124003	9264	22	None	-	1	Human	7.1	pEC50	=	7.1	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells	ChEMBL		None	None	None		None	10.1021/np058114h
		2116	9264	22	None	-	1	Human	7.1	pEC50	=	7.1	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells	ChEMBL		None	None	None		None	10.1021/np058114h
		CHEMBL507824	9264	22	None	-	1	Human	7.1	pEC50	=	7.1	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells	ChEMBL		None	None	None		None	10.1021/np058114h
		CHEMBL334721	218178	1	None	-	3	Golden hamster	10.1	pIC50	=	10.1	Binding	Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1016/S0960-894X(96)00570-7
		104974	10248	31	None	1	7	Human	9.9	pIC50	=	9.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(98)00395-3
		2111	10248	31	None	1	7	Human	9.9	pIC50	=	9.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(98)00395-3
		3481	10248	31	None	1	7	Human	9.9	pIC50	=	9.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(98)00395-3
		CHEMBL308148	10248	31	None	1	7	Human	9.9	pIC50	=	9.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(98)00395-3
		DB06660	10248	31	None	1	7	Human	9.9	pIC50	=	9.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(98)00395-3
		68932311	131571	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	565	5	1	4	4.3	CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		CHEMBL3642170	131571	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	565	5	1	4	4.3	CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		68870199	131572	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	535	5	0	3	5.8	CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642171	131572	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	535	5	0	3	5.8	CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		68932793	131574	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	599	5	1	4	4.7	CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		CHEMBL3642173	131574	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	599	5	1	4	4.7	CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		68930433	131567	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	583	4	0	3	5.7	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642166	131567	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	583	4	0	3	5.7	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		68928720	131575	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	609	5	1	4	4.4	CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		CHEMBL3642174	131575	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	609	5	1	4	4.4	CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		68870858	131569	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	555	5	0	3	5.6	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642168	131569	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	555	5	0	3	5.6	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		68870105	131565	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	549	4	0	3	5.4	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642164	131565	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	549	4	0	3	5.4	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		68932418	131573	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	642	6	1	6	4.1	CN(C(=O)c1ccc(N2CCOCC2)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3(O)CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		CHEMBL3642172	131573	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	642	6	1	6	4.1	CN(C(=O)c1ccc(N2CCOCC2)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3(O)CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		68928842	131576	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	600	5	1	5	4.1	CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		CHEMBL3642175	131576	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	600	5	1	5	4.1	CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1	nan
		9959481	71993	0	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	559	7	0	3	6.2	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL182600	71993	0	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	559	7	0	3	6.2	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
		68869786	131568	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	600	5	0	5	4.5	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(N4CCOCC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642167	131568	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	600	5	0	5	4.5	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(N4CCOCC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		104974	10248	31	None	1	7	Human	9.4	pIC50	=	9.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00148-5
		2111	10248	31	None	1	7	Human	9.4	pIC50	=	9.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00148-5
		3481	10248	31	None	1	7	Human	9.4	pIC50	=	9.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00148-5
		CHEMBL308148	10248	31	None	1	7	Human	9.4	pIC50	=	9.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00148-5
		DB06660	10248	31	None	1	7	Human	9.4	pIC50	=	9.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00148-5
		71699787	131558	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	593	4	0	3	5.5	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642157	131558	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	593	4	0	3	5.5	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		693306	167208	57	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	290	6	0	3	4.1	CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1	nan
		CHEMBL4111499	167208	57	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	290	6	0	3	4.1	CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1	nan
		68932391	131566	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	545	5	0	4	4.7	COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1	nan
		CHEMBL3642165	131566	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	545	5	0	4	4.7	COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1	nan
		42611207	131564	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	651	4	0	3	6.7	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642163	131564	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	651	4	0	3	6.7	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		10929285	73483	0	None	-	2	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	507	7	0	4	4.8	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1	10.1016/j.bmcl.2005.05.134
		CHEMBL185572	73483	0	None	-	2	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	507	7	0	4	4.8	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1	10.1016/j.bmcl.2005.05.134
		104974	10248	31	None	1	7	Human	9.1	pIC50	=	9.1	Binding	Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00075-3
		2111	10248	31	None	1	7	Human	9.1	pIC50	=	9.1	Binding	Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00075-3
		3481	10248	31	None	1	7	Human	9.1	pIC50	=	9.1	Binding	Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00075-3
		CHEMBL308148	10248	31	None	1	7	Human	9.1	pIC50	=	9.1	Binding	Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00075-3
		DB06660	10248	31	None	1	7	Human	9.1	pIC50	=	9.1	Binding	Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/0960-894X(96)00075-3
		68932301	131570	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	594	4	0	4	4.9	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642169	131570	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	594	4	0	4	4.9	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		2089	9542	28	None	-	5	Golden hamster	9.0	pIC50	=	9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		3795	9542	28	None	-	5	Golden hamster	9.0	pIC50	=	9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		5311311	9542	28	None	-	5	Golden hamster	9.0	pIC50	=	9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		CHEMBL217406	9542	28	None	-	5	Golden hamster	9.0	pIC50	=	9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		10033398	124070	0	None	-	0	Golden hamster	9.0	pIC50	=	9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	824	27	9	10	-0.0	CCCN(C[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm00099a024
		CHEMBL339591	124070	0	None	-	0	Golden hamster	9.0	pIC50	=	9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	824	27	9	10	-0.0	CCCN(C[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm00099a024
		44392491	175089	0	None	-	1	Human	9.0	pIC50	=	9	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	556	7	1	4	5.2	NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL434142	175089	0	None	-	1	Human	9.0	pIC50	=	9	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	556	7	1	4	5.2	NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		71699790	131561	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	549	4	0	3	5.4	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642160	131561	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	549	4	0	3	5.4	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		72548703	168346	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		CHEMBL4128926	168346	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		44392351	73176	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	620	8	0	5	4.3	CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL185182	73176	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	620	8	0	5	4.3	CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		44392439	175154	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	557	7	1	4	5.2	O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL434548	175154	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	557	7	1	4	5.2	O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
		2089	9542	28	None	102	5	Human	8.8	pIC50	=	8.8	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		3795	9542	28	None	102	5	Human	8.8	pIC50	=	8.8	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		5311311	9542	28	None	102	5	Human	8.8	pIC50	=	8.8	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		CHEMBL217406	9542	28	None	102	5	Human	8.8	pIC50	=	8.8	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		71699791	131562	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	591	5	0	3	6.4	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642161	131562	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	591	5	0	3	6.4	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		10327914	24863	0	None	-	0	Golden hamster	8.0	pIC50	=	8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	782	25	10	10	-1.1	CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		CHEMBL126776	24863	0	None	-	0	Golden hamster	8.0	pIC50	=	8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	782	25	10	10	-1.1	CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		44392444	129112	0	None	-	1	Human	8.0	pIC50	=	8	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	481	7	0	3	4.8	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL359903	129112	0	None	-	1	Human	8.0	pIC50	=	8	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	481	7	0	3	4.8	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1	10.1016/j.bmcl.2005.05.134
		44319321	20476	0	None	-	0	Mouse	8.0	pIC50	=	8.0	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL1194933	20476	0	None	-	0	Mouse	8.0	pIC50	=	8.0	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL553554	20476	0	None	-	0	Mouse	8.0	pIC50	=	8.0	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		73265452	133223	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	609	4	0	4	5.8	CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	nan
		CHEMBL3651890	133223	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	609	4	0	4	5.8	CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	nan
		91535935	165398	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay	ChEMBL	532	7	1	4	6.8	C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/acsmedchemlett.7b00094
		CHEMBL4092276	165398	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay	ChEMBL	532	7	1	4	6.8	C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/acsmedchemlett.7b00094
		44411742	85078	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells	ChEMBL	441	4	1	3	4.5	O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1	10.1016/j.bmcl.2006.02.027
		CHEMBL210811	85078	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells	ChEMBL	441	4	1	3	4.5	O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1	10.1016/j.bmcl.2006.02.027
		2812	11551	101	None	-28	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	11551	101	None	-28	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		2090	9543	25	None	-38	4	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		5311312	9543	25	None	-38	4	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		CHEMBL437797	9543	25	None	-38	4	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		10010429	25814	0	None	-	0	Golden hamster	7.0	pIC50	=	7.0	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	776	26	9	10	-0.6	CCCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O	10.1021/jm00099a024
		CHEMBL128854	25814	0	None	-	0	Golden hamster	7.0	pIC50	=	7.0	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	776	26	9	10	-0.6	CCCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O	10.1021/jm00099a024
		49863734	22105	0	None	-13	4	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1477	21	11	14	6.8	CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm100157m
		CHEMBL1214027	22105	0	None	-13	4	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1477	21	11	14	6.8	CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm100157m
		CHEMBL103634	215237	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm9807151
		44305248	209666	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	585	8	1	3	7.0	CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1	10.1016/s0960-894x(02)00382-7
		CHEMBL62679	209666	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	585	8	1	3	7.0	CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1	10.1016/s0960-894x(02)00382-7
		10485206	124955	0	None	-	0	Golden hamster	7.0	pIC50	=	7.0	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	748	25	10	10	-1.3	CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		CHEMBL340880	124955	0	None	-	0	Golden hamster	7.0	pIC50	=	7.0	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	748	25	10	10	-1.3	CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		44384901	176683	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	579	8	1	4	5.7	COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1	10.1016/0960-894X(96)00148-5
		CHEMBL444086	176683	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	579	8	1	4	5.7	COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1	10.1016/0960-894X(96)00148-5
		44319082	174806	0	None	-	0	Mouse	7.9	pIC50	=	7.9	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	752	13	1	8	5.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL432183	174806	0	None	-	0	Mouse	7.9	pIC50	=	7.9	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	752	13	1	8	5.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL2372521	217048	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O	10.1021/jm00037a009
		10435115	127577	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	476	7	2	3	5.2	[O-][S+](c1ccccc1)C(c1ccccc1)C1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1016/s0960-894x(01)00074-9
		CHEMBL355541	127577	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	476	7	2	3	5.2	[O-][S+](c1ccccc1)C(c1ccccc1)C1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1016/s0960-894x(01)00074-9
		9940218	125116	2	None	-	0	Golden hamster	6.9	pIC50	=	6.9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	734	24	10	10	-1.7	CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		CHEMBL341015	125116	2	None	-	0	Golden hamster	6.9	pIC50	=	6.9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	734	24	10	10	-1.7	CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		67232184	133224	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	548	4	0	3	4.9	CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1	nan
		CHEMBL3651891	133224	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	548	4	0	3	4.9	CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1	nan
		44384902	66721	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	579	8	1	4	5.7	COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/0960-894X(96)00148-5
		CHEMBL173245	66721	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	579	8	1	4	5.7	COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/0960-894X(96)00148-5
		44319222	112920	0	None	-	0	Mouse	7.9	pIC50	=	7.9	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	657	10	1	6	5.9	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL313546	112920	0	None	-	0	Mouse	7.9	pIC50	=	7.9	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	657	10	1	6	5.9	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		73265453	133225	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	617	4	0	4	5.0	CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1	nan
		CHEMBL3651892	133225	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	617	4	0	4	5.0	CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1	nan
		CHEMBL2372519	217047	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O	10.1021/jm00037a009
		71458131	86459	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		CHEMBL2115343	86459	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		71452663	85317	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		CHEMBL2112070	85317	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		2750	210840	76	None	-2	12	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	210840	76	None	-2	12	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		9832198	113532	0	None	-	3	Human	6.9	pIC50	=	6.9	Binding	Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor	ChEMBL	788	15	4	8	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144351	113532	0	None	-	3	Human	6.9	pIC50	=	6.9	Binding	Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor	ChEMBL	788	15	4	8	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		44384986	136552	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	623	9	1	5	6.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C	10.1016/0960-894X(96)00148-5
		CHEMBL367528	136552	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	623	9	1	5	6.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C	10.1016/0960-894X(96)00148-5
		10366515	64352	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	450	6	2	3	4.6	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1016/s0960-894x(01)00074-9
		CHEMBL166675	64352	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	450	6	2	3	4.6	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1	10.1016/s0960-894x(01)00074-9
		CHEMBL2372516	217044	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O	10.1021/jm00037a009
		137647980	164716	3	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay	ChEMBL	600	7	1	4	7.9	C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1	10.1021/acsmedchemlett.7b00094
		CHEMBL4084542	164716	3	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay	ChEMBL	600	7	1	4	7.9	C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1	10.1021/acsmedchemlett.7b00094
		CHEMBL341065	218418	0	None	-	0	Golden hamster	6.9	pIC50	=	6.9	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1021/jm00099a024
		CHEMBL449091	220739	0	None	-	0	Golden hamster	5.9	pIC50	=	5.9	Binding	Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder	ChEMBL		None	None	None		C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O	10.1016/0960-894X(94)85022-4
		44312324	211463	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	534	7	2	2	5.8	CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL73896	211463	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	534	7	2	2	5.8	CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		44312219	109158	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	506	6	3	2	5.1	O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL303868	109158	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	506	6	3	2	5.1	O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		44380176	168288	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	613	10	1	3	7.7	CN(C[C@@H](CCN1CCC(NC(=O)c2ccccc2)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(01)00074-9
		CHEMBL412815	168288	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	613	10	1	3	7.7	CN(C[C@@H](CCN1CCC(NC(=O)c2ccccc2)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(01)00074-9
		44312056	211502	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	595	7	2	4	6.2	CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		CHEMBL74237	211502	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	595	7	2	4	6.2	CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		10349900	113526	0	None	-	3	Rat	6.9	pIC50	=	6.9	Binding	Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	716	13	3	7	2.8	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144343	113526	0	None	-	3	Rat	6.9	pIC50	=	6.9	Binding	Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	716	13	3	7	2.8	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		6518171	175075	55	None	-4	8	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	495	12	2	6	4.9	CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1	nan
		CHEMBL434063	175075	55	None	-4	8	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	495	12	2	6	4.9	CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1	nan
		3561	25849	39	None	-1	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	25849	39	None	-1	11	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		2098	10466	36	None	-	6	Golden hamster	6.8	pIC50	=	6.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		36511	10466	36	None	-	6	Golden hamster	6.8	pIC50	=	6.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		3805	10466	36	None	-	6	Golden hamster	6.8	pIC50	=	6.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		3835	10466	36	None	-	6	Golden hamster	6.8	pIC50	=	6.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		CHEMBL235363	10466	36	None	-	6	Golden hamster	6.8	pIC50	=	6.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		11038500	70327	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	507	9	0	4	4.8	CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL180049	70327	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	507	9	0	4	4.8	CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		10940813	73105	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	571	9	0	5	2.8	CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL185007	73105	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	571	9	0	5	2.8	CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		9914897	185837	0	None	-	0	Golden hamster	5.8	pIC50	=	5.8	Binding	Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand	ChEMBL	528	15	4	4	5.0	CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1	10.1016/0960-894X(95)00313-I
		CHEMBL47146	185837	0	None	-	0	Golden hamster	5.8	pIC50	=	5.8	Binding	Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand	ChEMBL	528	15	4	4	5.0	CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1	10.1016/0960-894X(95)00313-I
		9914897	185837	0	None	-	0	Golden hamster	5.8	pIC50	=	5.8	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	528	15	4	4	5.0	CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1	10.1021/jm950892r
		CHEMBL47146	185837	0	None	-	0	Golden hamster	5.8	pIC50	=	5.8	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	528	15	4	4	5.0	CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1	10.1021/jm950892r
		148124	213878	86	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	nan
		CHEMBL3545252	213878	86	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	nan
		CHEMBL92	213878	86	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	nan
		44319307	113324	0	None	-	0	Mouse	7.8	pIC50	=	7.8	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL314119	113324	0	None	-	0	Mouse	7.8	pIC50	=	7.8	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		44319306	113874	0	None	-	0	Mouse	7.8	pIC50	=	7.8	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL315923	113874	0	None	-	0	Mouse	7.8	pIC50	=	7.8	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		44212282	68061	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	579	8	1	4	5.7	COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/0960-894X(96)00148-5
		CHEMBL176682	68061	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	579	8	1	4	5.7	COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/0960-894X(96)00148-5
		CHEMBL276294	217607	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O	10.1021/jm00037a009
		138106918	202265	42	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	nan
		5311497	202265	42	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	nan
		CHEMBL553025	202265	42	None	-	1	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	nan
		6918276	22383	7	None	-56	8	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	22383	7	None	-56	8	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL306072	217756	0	None	-	0	Golden hamster	5.8	pIC50	=	5.8	Binding	Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O	10.1016/0960-894X(94)85022-4
		71456198	85350	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	565	8	2	6	4.7	COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC	10.1016/s0960-894x(02)00382-7
		CHEMBL2112209	85350	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	565	8	2	6	4.7	COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC	10.1016/s0960-894x(02)00382-7
		44351724	26169	0	None	-	0	Golden hamster	6.8	pIC50	=	6.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	818	26	9	10	-0.4	CC(C)CC(=O)N(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O	10.1021/jm00099a024
		CHEMBL129301	26169	0	None	-	0	Golden hamster	6.8	pIC50	=	6.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	818	26	9	10	-0.4	CC(C)CC(=O)N(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O	10.1021/jm00099a024
		CHEMBL340847	218415	0	None	-	0	Golden hamster	5.8	pIC50	=	5.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NCCCC(=O)O)C(C)C)C(N)=O	10.1021/jm00099a024
		44312218	210919	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	542	8	1	4	5.5	CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		CHEMBL70461	210919	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	542	8	1	4	5.5	CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		11057	182928	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	182928	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	182928	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	182928	23	None	-1	20	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		44305511	209745	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	566	5	1	2	7.9	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1	10.1016/s0960-894x(02)00382-7
		CHEMBL63014	209745	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	566	5	1	2	7.9	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1	10.1016/s0960-894x(02)00382-7
		44335354	11706	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	629	7	2	4	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1	10.1016/s0960-894x(01)00631-x
		CHEMBL104708	11706	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	629	7	2	4	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1	10.1016/s0960-894x(01)00631-x
		10349900	113526	0	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	716	13	3	7	2.8	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144343	113526	0	None	-	3	Human	7.8	pIC50	=	7.8	Binding	Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	716	13	3	7	2.8	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		44319223	113882	0	None	-	0	Mouse	7.8	pIC50	=	7.8	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	669	11	1	7	5.7	COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1	10.1016/S0960-894X(97)10013-0
		CHEMBL315982	113882	0	None	-	0	Mouse	7.8	pIC50	=	7.8	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	669	11	1	7	5.7	COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1	10.1016/S0960-894X(97)10013-0
		22901331	18753	0	None	-	1	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum	ChEMBL	424	4	0	4	5.2	CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21	10.1021/jm00109a034
		54435601	18753	0	None	-	1	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum	ChEMBL	424	4	0	4	5.2	CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21	10.1021/jm00109a034
		59922977	18753	0	None	-	1	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum	ChEMBL	424	4	0	4	5.2	CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21	10.1021/jm00109a034
		CHEMBL1183068	18753	0	None	-	1	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum	ChEMBL	424	4	0	4	5.2	CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21	10.1021/jm00109a034
		CHEMBL278294	18753	0	None	-	1	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum	ChEMBL	424	4	0	4	5.2	CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21	10.1021/jm00109a034
		CHEMBL406812	219400	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O	10.1021/jm00037a009
		3823	56995	42	None	-36	11	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	56995	42	None	-36	11	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	56995	42	None	-36	11	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		44444681	101148	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to NK2 receptorBinding affinity to NK2 receptor	ChEMBL	501	5	0	3	6.7	C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1016/j.bmcl.2007.06.085
		CHEMBL250798	101148	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to NK2 receptorBinding affinity to NK2 receptor	ChEMBL	501	5	0	3	6.7	C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1016/j.bmcl.2007.06.085
		15730	77893	80	None	-2	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	77893	80	None	-2	10	Human	4.8	pIC50	=	4.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		10258592	105983	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	639	7	0	4	6.8	CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21	10.1016/s0960-894x(98)00215-7
		CHEMBL281481	105983	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	639	7	0	4	6.8	CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21	10.1016/s0960-894x(98)00215-7
		2090	9543	25	None	-	4	Golden hamster	7.8	pIC50	=	7.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		5311312	9543	25	None	-	4	Golden hamster	7.8	pIC50	=	7.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		CHEMBL437797	9543	25	None	-	4	Golden hamster	7.8	pIC50	=	7.8	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm00099a024
		15391369	109605	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	518	6	2	2	5.5	CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL305509	109605	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	518	6	2	2	5.5	CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		49863732	22103	0	None	-24	4	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1266	18	10	12	6.1	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		CHEMBL1214025	22103	0	None	-24	4	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1266	18	10	12	6.1	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		9874168	212483	4	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/0960-894X(96)00148-5
		CHEMBL82386	212483	4	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/0960-894X(96)00148-5
		CHEMBL2372525	217049	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O	10.1021/jm00037a009
		71452678	85352	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	591	5	2	3	6.4	Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1	10.1016/s0960-894x(02)00382-7
		CHEMBL2112211	85352	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	591	5	2	3	6.4	Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1	10.1016/s0960-894x(02)00382-7
		10350454	113508	0	None	-	3	Rat	6.7	pIC50	=	6.7	Binding	Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor	ChEMBL	815	18	4	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144209	113508	0	None	-	3	Rat	6.7	pIC50	=	6.7	Binding	Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor	ChEMBL	815	18	4	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		44384987	68128	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	609	9	1	5	5.7	COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/0960-894X(96)00148-5
		CHEMBL176769	68128	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	609	9	1	5	5.7	COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/0960-894X(96)00148-5
		44335466	11826	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	720	8	2	5	6.0	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1	10.1016/s0960-894x(01)00631-x
		CHEMBL105295	11826	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	720	8	2	5	6.0	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1	10.1016/s0960-894x(01)00631-x
		44319057	212623	0	None	-	0	Mouse	6.7	pIC50	=	6.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	605	10	1	6	5.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL83585	212623	0	None	-	0	Mouse	6.7	pIC50	=	6.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	605	10	1	6	5.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL415600	219973	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O	10.1021/jm00037a009
		2335	18620	22	None	-3	12	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	18620	22	None	-3	12	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	18620	22	None	-3	12	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	18620	22	None	-3	12	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		10395276	25691	0	None	-	0	Golden hamster	6.7	pIC50	=	6.7	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	748	24	9	10	-1.4	CC(C)C[C@@H](CN(C)[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		CHEMBL128521	25691	0	None	-	0	Golden hamster	6.7	pIC50	=	6.7	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	748	24	9	10	-1.4	CC(C)C[C@@H](CN(C)[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		176	7186	66	None	-4	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	7186	66	None	-4	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	7186	66	None	-4	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	7186	66	None	-4	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	7186	66	None	-4	31	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		3191	109635	97	None	-12	25	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	109635	97	None	-12	25	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL36402	218700	0	None	-	0	Golden hamster	4.7	pIC50	=	4.7	Binding	Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O	10.1016/0960-894X(95)00254-Q
		73265451	133222	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	666	4	0	3	6.8	CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1	nan
		CHEMBL3651889	133222	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	666	4	0	3	6.8	CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1	nan
		71699789	131560	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	529	4	0	3	5.0	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3642159	131560	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	529	4	0	3	5.0	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		9853506	19861	0	None	-	0	Mouse	8.7	pIC50	=	8.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	709	10	0	7	6.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL1190281	19861	0	None	-	0	Mouse	8.7	pIC50	=	8.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	709	10	0	7	6.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL540553	19861	0	None	-	0	Mouse	8.7	pIC50	=	8.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	709	10	0	7	6.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		44319086	20484	0	None	-	0	Mouse	8.7	pIC50	=	8.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	722	10	0	7	6.0	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL1194977	20484	0	None	-	0	Mouse	8.7	pIC50	=	8.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	722	10	0	7	6.0	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL553617	20484	0	None	-	0	Mouse	8.7	pIC50	=	8.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	722	10	0	7	6.0	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		9852376	105878	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	639	8	0	4	6.6	CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21	10.1016/s0960-894x(98)00215-7
		CHEMBL280789	105878	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	639	8	0	4	6.6	CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21	10.1016/s0960-894x(98)00215-7
		71699792	131563	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	636	5	0	3	7.5	CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1	nan
		CHEMBL3642162	131563	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	636	5	0	3	7.5	CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1	nan
		44404006	139534	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2	ChEMBL	549	7	1	3	5.7	NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1	10.1021/jm058225d
		CHEMBL370013	139534	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2	ChEMBL	549	7	1	3	5.7	NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1	10.1021/jm058225d
		71699788	131559	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	545	5	0	4	4.7	COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1	nan
		CHEMBL3642158	131559	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.	ChEMBL	545	5	0	4	4.7	COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1	nan
		73265455	133227	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	660	5	1	4	5.4	CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	nan
		CHEMBL3651894	133227	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	660	5	1	4	5.4	CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	nan
		3570748	64293	28	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	414	7	1	3	4.1	COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1016/s0960-894x(01)00074-9
		CHEMBL166161	64293	28	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	414	7	1	3	4.1	COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1016/s0960-894x(01)00074-9
		CHEMBL2390989	217190	16	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1016/j.bmc.2013.03.016
		44276792	105907	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	604	8	1	4	6.5	O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1	10.1016/s0960-894x(98)00215-7
		CHEMBL281019	105907	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	604	8	1	4	6.5	O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1	10.1016/s0960-894x(98)00215-7
		44392445	73129	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	495	8	0	3	5.2	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL185133	73129	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	495	8	0	3	5.2	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1	10.1016/j.bmcl.2005.05.134
		2098	10466	36	None	-	6	Rat	6.7	pIC50	=	6.7	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		None	10.1021/jm00037a009
		36511	10466	36	None	-	6	Rat	6.7	pIC50	=	6.7	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		None	10.1021/jm00037a009
		3805	10466	36	None	-	6	Rat	6.7	pIC50	=	6.7	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		None	10.1021/jm00037a009
		3835	10466	36	None	-	6	Rat	6.7	pIC50	=	6.7	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		None	10.1021/jm00037a009
		CHEMBL235363	10466	36	None	-	6	Rat	6.7	pIC50	=	6.7	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		None	10.1021/jm00037a009
		44335410	11772	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	574	7	1	2	7.5	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1	10.1016/s0960-894x(01)00631-x
		CHEMBL105009	11772	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	574	7	1	2	7.5	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1	10.1016/s0960-894x(01)00631-x
		44276738	103965	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	560	6	0	2	7.9	O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(98)00215-7
		CHEMBL26831	103965	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	560	6	0	2	7.9	O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(98)00215-7
		9874168	212483	4	None	-	0	Mouse	7.7	pIC50	=	7.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL82386	212483	4	None	-	0	Mouse	7.7	pIC50	=	7.7	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		44312169	211207	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	492	5	3	2	5.4	O=C(Nc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL72140	211207	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	492	5	3	2	5.4	O=C(Nc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		76287260	132525	25	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting method	ChEMBL	440	6	0	7	4.1	CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21	10.1021/acs.jmedchem.9b00322
		CHEMBL3647536	132525	25	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting method	ChEMBL	440	6	0	7	4.1	CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21	10.1021/acs.jmedchem.9b00322
		44312145	211495	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	520	7	3	2	5.1	O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL74176	211495	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	520	7	3	2	5.1	O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		9843958	207572	1	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	400	6	2	3	3.5	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/s0960-894x(01)00074-9
		CHEMBL60064	207572	1	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	400	6	2	3	3.5	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/s0960-894x(01)00074-9
		1212	8443	50	None	-389	65	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	8443	50	None	-389	65	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	8443	50	None	-389	65	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	8443	50	None	-389	65	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	8443	50	None	-389	65	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		44319250	113784	0	None	-	0	Mouse	6.6	pIC50	=	6.6	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	589	10	1	6	4.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL315322	113784	0	None	-	0	Mouse	6.6	pIC50	=	6.6	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	589	10	1	6	4.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		10099939	11759	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(01)00631-x
		CHEMBL104954	11759	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(01)00631-x
		9830304	114124	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	608	7	2	4	5.2	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12	10.1016/s0960-894x(01)00631-x
		CHEMBL317632	114124	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	608	7	2	4	5.2	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12	10.1016/s0960-894x(01)00631-x
		10099939	11759	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		CHEMBL104954	11759	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		44312257	109687	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	567	7	2	4	5.6	CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		CHEMBL306065	109687	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	567	7	2	4	5.6	CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		25129133	195666	0	None	-10	4	Rat	7.6	pIC50	=	7.6	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1208	27	10	11	4.9	CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		CHEMBL507340	195666	0	None	-10	4	Rat	7.6	pIC50	=	7.6	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1208	27	10	11	4.9	CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		23653789	10359	24	None	1	2	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	555	5	0	3	7.7	O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F	10.1021/jm400751p
		9280	10359	24	None	1	2	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	555	5	0	3	7.7	O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F	10.1021/jm400751p
		CHEMBL447955	10359	24	None	1	2	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	555	5	0	3	7.7	O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F	10.1021/jm400751p
		DB12973	10359	24	None	1	2	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	555	5	0	3	7.7	O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F	10.1021/jm400751p
		10350528	113510	0	None	-	3	Rat	6.6	pIC50	=	6.6	Binding	Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor	ChEMBL	831	18	4	9	4.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144210	113510	0	None	-	3	Rat	6.6	pIC50	=	6.6	Binding	Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor	ChEMBL	831	18	4	9	4.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		2098	10466	36	None	-457	6	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		36511	10466	36	None	-457	6	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		3805	10466	36	None	-457	6	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		3835	10466	36	None	-457	6	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		CHEMBL235363	10466	36	None	-457	6	Human	6.6	pIC50	=	6.6	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		44379971	65527	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	398	3	2	3	3.5	[O-][S+](C[C@]1(O)CCN2CCc3c([nH]c4ccc(F)cc34)[C@H]2C1)c1ccccc1	10.1016/s0960-894x(01)00074-9
		CHEMBL168632	65527	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	398	3	2	3	3.5	[O-][S+](C[C@]1(O)CCN2CCc3c([nH]c4ccc(F)cc34)[C@H]2C1)c1ccccc1	10.1016/s0960-894x(01)00074-9
		44312028	109629	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	558	9	1	5	5.1	CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		CHEMBL305609	109629	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	558	9	1	5	5.1	CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		44335376	11317	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	717	7	2	4	6.3	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1	10.1016/s0960-894x(01)00631-x
		CHEMBL102376	11317	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	717	7	2	4	6.3	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1	10.1016/s0960-894x(01)00631-x
		155565189	182344	0	None	2	4	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
		CHEMBL4579120	182344	0	None	2	4	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
		392622	63086	95	None	2	4	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	nan
		CHEMBL163	63086	95	None	2	4	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	nan
		28417	46813	49	None	-1	12	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	46813	49	None	-1	12	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		2600	10551	74	None	-6	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	10551	74	None	-6	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	10551	74	None	-6	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	10551	74	None	-6	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	10551	74	None	-6	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		9984184	211428	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	520	6	2	2	5.4	CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL73618	211428	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	520	6	2	2	5.4	CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL2112246	216012	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.	ChEMBL		None	None	None		C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O	10.1021/jm000316h
		2726	7706	68	None	-125	72	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	7706	68	None	-125	72	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	7706	68	None	-125	72	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	7706	68	None	-125	72	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	7706	68	None	-125	72	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		10055928	123403	0	None	-	0	Golden hamster	6.6	pIC50	=	6.6	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	762	25	9	10	-1.0	CCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O	10.1021/jm00099a024
		CHEMBL336849	123403	0	None	-	0	Golden hamster	6.6	pIC50	=	6.6	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	762	25	9	10	-1.0	CCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O	10.1021/jm00099a024
		44319249	212851	0	None	-	0	Mouse	5.6	pIC50	=	5.6	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	631	12	1	8	4.4	COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL85499	212851	0	None	-	0	Mouse	5.6	pIC50	=	5.6	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	631	12	1	8	4.4	COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC	10.1016/S0960-894X(97)10013-0
		9869033	107200	5	None	-	0	Bovine	5.6	pIC50	=	5.6	Binding	Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder	ChEMBL	463	6	1	3	5.9	Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1	10.1016/0960-894X(96)00287-9
		CHEMBL290364	107200	5	None	-	0	Bovine	5.6	pIC50	=	5.6	Binding	Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder	ChEMBL	463	6	1	3	5.9	Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1	10.1016/0960-894X(96)00287-9
		71450941	86294	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	595	5	2	3	6.2	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1	10.1016/s0960-894x(02)00382-7
		CHEMBL2113739	86294	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	595	5	2	3	6.2	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1	10.1016/s0960-894x(02)00382-7
		16220269	196439	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of neurokinin 2 receptorInhibition of neurokinin 2 receptor	ChEMBL	361	3	1	2	4.4	CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O	10.1073/pnas.0605125104
		CHEMBL515170	196439	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Inhibition of neurokinin 2 receptorInhibition of neurokinin 2 receptor	ChEMBL	361	3	1	2	4.4	CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O	10.1073/pnas.0605125104
		53232	195404	95	None	1	2	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	nan
		CHEMBL503	195404	95	None	1	2	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	nan
		CHEMBL2115376	216046	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O	10.1021/jm00037a009
		CHEMBL2369767	216463	0	None	-	0	Golden hamster	5.5	pIC50	=	5.5	Binding	Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder	ChEMBL		None	None	None		C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O	10.1016/0960-894X(94)85022-4
		64143	205643	62	None	-1	8	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		CHEMBL584	205643	62	None	-1	8	Human	4.5	pIC50	=	4.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		2247	7293	81	None	-44	42	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	7293	81	None	-44	42	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	7293	81	None	-44	42	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	7293	81	None	-44	42	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	7293	81	None	-44	42	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		9831641	86472	5	None	-	0	Guinea pig	8.5	pIC50	=	8.5	Binding	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane	ChEMBL	672	8	0	7	6.0	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
		CHEMBL2115415	86472	5	None	-	0	Guinea pig	8.5	pIC50	=	8.5	Binding	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane	ChEMBL	672	8	0	7	6.0	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
		44319224	113853	0	None	-	0	Mouse	8.5	pIC50	=	8.5	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	722	10	0	7	6.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL315814	113853	0	None	-	0	Mouse	8.5	pIC50	=	8.5	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	722	10	0	7	6.0	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		44392392	136951	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	555	7	0	4	5.4	O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL367815	136951	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	555	7	0	4	5.4	O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		127032997	145310	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells	ChEMBL	748	24	10	10	-2.1	CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1016/j.bmc.2016.03.006
		CHEMBL3775108	145310	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells	ChEMBL	748	24	10	10	-2.1	CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1016/j.bmc.2016.03.006
		CHEMBL2390989	217190	16	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1016/j.bmc.2016.11.014
		137633652	163375	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	749	24	10	10	-1.5	CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/acs.jmedchem.6b01422
		CHEMBL4068783	163375	0	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	749	24	10	10	-1.5	CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/acs.jmedchem.6b01422
		2090	9543	25	None	-	4	Golden hamster	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL		None	None	None		None	10.1021/jm950892r
		5311312	9543	25	None	-	4	Golden hamster	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL		None	None	None		None	10.1021/jm950892r
		CHEMBL437797	9543	25	None	-	4	Golden hamster	8.4	pIC50	=	8.4	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL		None	None	None		None	10.1021/jm950892r
		44319308	113155	0	None	-	0	Mouse	8.4	pIC50	=	8.4	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	709	10	0	7	6.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL313931	113155	0	None	-	0	Mouse	8.4	pIC50	=	8.4	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	709	10	0	7	6.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		15485361	104005	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	576	9	0	3	7.5	CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1	10.1016/s0960-894x(98)00215-7
		CHEMBL26860	104005	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	576	9	0	3	7.5	CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1	10.1016/s0960-894x(98)00215-7
		9915372	133837	1	None	-1	2	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	543	8	1	5	2.2	NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL365613	133837	1	None	-1	2	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	543	8	1	5	2.2	NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		44305557	209592	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2	ChEMBL	522	8	2	5	6.3	COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC	10.1021/jm058225d
		CHEMBL62341	209592	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2	ChEMBL	522	8	2	5	6.3	COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC	10.1021/jm058225d
		44305557	209592	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	522	8	2	5	6.3	COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC	10.1016/s0960-894x(02)00382-7
		CHEMBL62341	209592	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	522	8	2	5	6.3	COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC	10.1016/s0960-894x(02)00382-7
		CHEMBL431641	220405	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm9807151
		71458099	86366	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		CHEMBL2114398	86366	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		155558726	181587	0	None	-3	4	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
		CHEMBL4562303	181587	0	None	-3	4	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
		5353853	24758	47	None	-14	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	24758	47	None	-14	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	24758	47	None	-14	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		44301871	107524	5	None	-	1	Golden hamster	5.5	pIC50	=	5.5	Binding	Concentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladderConcentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladder	ChEMBL	441	9	3	3	4.4	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1	10.1016/S0960-894X(97)00346-6
		CHEMBL292766	107524	5	None	-	1	Golden hamster	5.5	pIC50	=	5.5	Binding	Concentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladderConcentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladder	ChEMBL	441	9	3	3	4.4	O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1	10.1016/S0960-894X(97)00346-6
		CHEMBL311405	217878	16	None	-	0	Golden hamster	5.5	pIC50	=	5.5	Binding	Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1016/0960-894X(94)85022-4
		44212284	66762	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	609	9	1	5	5.7	COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1	10.1016/0960-894X(96)00148-5
		CHEMBL173420	66762	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	609	9	1	5	5.7	COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1	10.1016/0960-894X(96)00148-5
		CHEMBL102128	215233	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm9807151
		23294214	175939	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	590	7	1	4	6.9	O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(98)00215-7
		CHEMBL440465	175939	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	590	7	1	4	6.9	O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(98)00215-7
		CHEMBL406442	219387	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O	10.1021/jm00037a009
		1016	10519	78	None	-16	35	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	10519	78	None	-16	35	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	10519	78	None	-16	35	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	10519	78	None	-16	35	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	10519	78	None	-16	35	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	10519	78	None	-16	35	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL103939	215239	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm9807151
		CHEMBL2115375	216045	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O	10.1021/jm00037a009
		1836	9370	59	None	-40	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		3340	9370	59	None	-40	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		5281040	9370	59	None	-40	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		CHEMBL787	9370	59	None	-40	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		DB00471	9370	59	None	-40	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		9832198	113532	0	None	-	3	Rat	6.4	pIC50	=	6.4	Binding	Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor	ChEMBL	788	15	4	8	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144351	113532	0	None	-	3	Rat	6.4	pIC50	=	6.4	Binding	Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor	ChEMBL	788	15	4	8	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		10393390	105053	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	576	8	0	3	7.6	CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1	10.1016/s0960-894x(98)00215-7
		CHEMBL27463	105053	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	576	8	0	3	7.6	CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1	10.1016/s0960-894x(98)00215-7
		CHEMBL216813	216120	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O	10.1021/jm00037a009
		132837	9018	55	None	-18	5	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1021/jm100157m
		9461	9018	55	None	-18	5	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1021/jm100157m
		CHEMBL22870	9018	55	None	-18	5	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1021/jm100157m
		2351	10059	64	None	-13	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	10059	64	None	-13	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	10059	64	None	-13	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	10059	64	None	-13	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	10059	64	None	-13	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		44386230	68137	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	735	8	1	4	7.2	COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br	10.1016/0960-894X(96)00148-5
		CHEMBL176811	68137	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	735	8	1	4	7.2	COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br	10.1016/0960-894X(96)00148-5
		44319084	20469	0	None	-	0	Mouse	8.4	pIC50	=	8.4	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	723	10	0	8	5.4	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL1194867	20469	0	None	-	0	Mouse	8.4	pIC50	=	8.4	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	723	10	0	8	5.4	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL553451	20469	0	None	-	0	Mouse	8.4	pIC50	=	8.4	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	723	10	0	8	5.4	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		133	9274	52	None	-165	43	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	9274	52	None	-165	43	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	9274	52	None	-165	43	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	9274	52	None	-165	43	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	9274	52	None	-165	43	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL405209	219328	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O	10.1021/jm00037a009
		49863731	22102	0	None	-5	3	Rat	7.4	pIC50	=	7.4	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1266	18	10	12	6.1	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		CHEMBL1214024	22102	0	None	-5	3	Rat	7.4	pIC50	=	7.4	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1266	18	10	12	6.1	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		1024	8072	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		162639143	8072	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		5284373	8072	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		760	8072	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		CHEMBL160	8072	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		DB00091	8072	71	None	-	1	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		3598	194600	76	None	-1	7	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		CHEMBL496	194600	76	None	-1	7	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		73265454	133226	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	646	5	1	4	6.3	COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1	nan
		CHEMBL3651893	133226	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	646	5	1	4	6.3	COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1	nan
		44384677	138236	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	667	11	1	6	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C	10.1016/0960-894X(96)00148-5
		CHEMBL369174	138236	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	667	11	1	6	6.5	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C	10.1016/0960-894X(96)00148-5
		73265449	131190	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	630	4	0	3	6.0	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1	nan
		CHEMBL3639507	131190	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	630	4	0	3	6.0	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1	nan
		44312285	109734	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	703	7	2	4	7.6	CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		CHEMBL306400	109734	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	703	7	2	4	7.6	CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		122179477	128252	5	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of NK2 receptor (unknown origin)Inhibition of NK2 receptor (unknown origin)	ChEMBL	525	5	3	9	3.2	CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1	10.1021/ml500514w
		CHEMBL3582336	128252	5	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of NK2 receptor (unknown origin)Inhibition of NK2 receptor (unknown origin)	ChEMBL	525	5	3	9	3.2	CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1	10.1021/ml500514w
		71449072	85353	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	645	5	2	3	7.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00382-7
		CHEMBL2112212	85353	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	645	5	2	3	7.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00382-7
		11059058	16863	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
		CHEMBL115444	16863	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
		10350454	113508	0	None	-	3	Human	7.4	pIC50	=	7.4	Binding	Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor	ChEMBL	815	18	4	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144209	113508	0	None	-	3	Human	7.4	pIC50	=	7.4	Binding	Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor	ChEMBL	815	18	4	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		44290659	108310	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane	ChEMBL	654	8	1	7	5.7	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
		CHEMBL298247	108310	0	None	-	0	Guinea pig	7.4	pIC50	=	7.4	Binding	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane	ChEMBL	654	8	1	7	5.7	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
		CHEMBL411230	219653	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O	10.1021/jm00037a009
		44288896	175766	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder	ChEMBL	517	5	1	3	6.2	O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12	10.1016/0960-894X(96)00287-9
		CHEMBL43912	175766	0	None	-	0	Bovine	5.4	pIC50	=	5.4	Binding	Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder	ChEMBL	517	5	1	3	6.2	O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12	10.1016/0960-894X(96)00287-9
		44312256	211359	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	554	7	2	5	5.7	CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		CHEMBL73097	211359	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	554	7	2	5	5.7	CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		1752	52535	59	None	-1	5	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		CHEMBL153062	52535	59	None	-1	5	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		1548953	214458	27	None	-7	17	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	214458	27	None	-7	17	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL1201469	21279	0	None	1	4	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		CHEMBL2112245	216011	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.	ChEMBL		None	None	None		C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O	10.1021/jm000316h
		10350528	113510	0	None	-	3	Human	7.3	pIC50	=	7.3	Binding	Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor	ChEMBL	831	18	4	9	4.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144210	113510	0	None	-	3	Human	7.3	pIC50	=	7.3	Binding	Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor	ChEMBL	831	18	4	9	4.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		11951302	111621	0	None	-	1	Human	4.3	pIC50	=	4.3	Binding	Antagonist activity at human NK2 receptorAntagonist activity at human NK2 receptor	ChEMBL	404	7	2	5	3.5	COCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1	10.1021/jm4010708
		CHEMBL3109772	111621	0	None	-	1	Human	4.3	pIC50	=	4.3	Binding	Antagonist activity at human NK2 receptorAntagonist activity at human NK2 receptor	ChEMBL	404	7	2	5	3.5	COCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1	10.1021/jm4010708
		2406	107180	89	None	-16	12	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL290106	107180	89	None	-16	12	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		4189	213701	96	None	-18	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	213701	96	None	-18	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	213701	96	None	-18	34	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		10439730	113534	0	None	-	3	Rat	6.3	pIC50	=	6.3	Binding	Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	702	12	3	6	3.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144353	113534	0	None	-	3	Rat	6.3	pIC50	=	6.3	Binding	Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	702	12	3	6	3.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		44402934	77847	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2	ChEMBL	589	9	1	3	6.2	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1	10.1021/jm058225d
		CHEMBL195222	77847	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2	ChEMBL	589	9	1	3	6.2	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1	10.1021/jm058225d
		10379	9833	39	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor	ChEMBL	340	5	1	7	3.3	CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C	10.1021/jm900025h
		9884366	9833	39	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor	ChEMBL	340	5	1	7	3.3	CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C	10.1021/jm900025h
		CHEMBL482950	9833	39	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor	ChEMBL	340	5	1	7	3.3	CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C	10.1021/jm900025h
		DB12572	9833	39	None	-	1	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor	ChEMBL	340	5	1	7	3.3	CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C	10.1021/jm900025h
		CHEMBL264341	217393	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O	10.1021/jm00037a009
		5318	22348	49	None	-1	13	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1200348	22348	49	None	-1	13	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1221	22348	49	None	-1	13	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		9939040	11782	7	None	-2	4	Human	8.3	pIC50	=	8.3	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00631-x
		CHEMBL105060	11782	7	None	-2	4	Human	8.3	pIC50	=	8.3	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00631-x
		44335319	114287	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	626	8	2	4	5.7	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00631-x
		CHEMBL318606	114287	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	626	8	2	4	5.7	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00631-x
		25109291	198165	10	None	-72	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		CHEMBL519240	198165	10	None	-72	8	Human	8.2	pIC50	=	8.2	Binding	Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		10101612	124075	0	None	-	0	Golden hamster	7.3	pIC50	=	7.3	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	752	25	10	11	-2.0	CSCC[C@H](NC[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1021/jm00099a024
		CHEMBL339615	124075	0	None	-	0	Golden hamster	7.3	pIC50	=	7.3	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	752	25	10	11	-2.0	CSCC[C@H](NC[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1021/jm00099a024
		44276673	104132	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	604	7	1	4	6.6	O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(98)00215-7
		CHEMBL26951	104132	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	604	7	1	4	6.6	O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(98)00215-7
		11989776	9481	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human NK2 receptorInhibition of human NK2 receptor	ChEMBL	569	5	1	6	5.9	COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1	10.1016/j.bmcl.2006.08.085
		2130	9481	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human NK2 receptorInhibition of human NK2 receptor	ChEMBL	569	5	1	6	5.9	COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1	10.1016/j.bmcl.2006.08.085
		CHEMBL221445	9481	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human NK2 receptorInhibition of human NK2 receptor	ChEMBL	569	5	1	6	5.9	COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1	10.1016/j.bmcl.2006.08.085
		44305271	109021	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	528	4	0	2	7.0	CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1	10.1016/s0960-894x(02)00382-7
		CHEMBL303119	109021	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	528	4	0	2	7.0	CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1	10.1016/s0960-894x(02)00382-7
		44291515	107915	0	None	-	0	Golden hamster	5.3	pIC50	=	5.3	Binding	Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand	ChEMBL	580	17	4	5	4.6	CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O	10.1016/S0960-894X(00)80360-1
		CHEMBL295301	107915	0	None	-	0	Golden hamster	5.3	pIC50	=	5.3	Binding	Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand	ChEMBL	580	17	4	5	4.6	CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O	10.1016/S0960-894X(00)80360-1
		44305544	209853	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	582	5	1	2	8.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1	10.1016/s0960-894x(02)00382-7
		CHEMBL63785	209853	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	582	5	1	2	8.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1	10.1016/s0960-894x(02)00382-7
		5362440	16793	63	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	613	11	4	7	2.9	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O	nan
		CHEMBL115	16793	63	None	-	1	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	613	11	4	7	2.9	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O	nan
		10907460	16600	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL113956	16600	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL2372444	217024	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O	10.1021/jm00037a009
		44281769	116437	7	None	-	0	Golden hamster	5.3	pIC50	=	5.3	Binding	Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand	ChEMBL	484	10	4	4	3.2	NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1	10.1016/0960-894X(95)00254-Q
		CHEMBL32248	116437	7	None	-	0	Golden hamster	5.3	pIC50	=	5.3	Binding	Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand	ChEMBL	484	10	4	4	3.2	NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1	10.1016/0960-894X(95)00254-Q
		44345938	18775	0	None	-	0	Golden hamster	5.3	pIC50	=	5.3	Binding	Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder	ChEMBL	350	7	4	3	1.3	NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/S0960-894X(96)00570-7
		CHEMBL118328	18775	0	None	-	0	Golden hamster	5.3	pIC50	=	5.3	Binding	Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder	ChEMBL	350	7	4	3	1.3	NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12	10.1016/S0960-894X(96)00570-7
		44212281	137394	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	609	9	1	5	5.7	COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/0960-894X(96)00148-5
		CHEMBL368159	137394	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	609	9	1	5	5.7	COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/0960-894X(96)00148-5
		CHEMBL2114442	216033	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O	10.1021/jm00037a009
		44190762	183659	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of radioligand from tachykinin NK2 receptorDisplacement of radioligand from tachykinin NK2 receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		CHEMBL461571	183659	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of radioligand from tachykinin NK2 receptorDisplacement of radioligand from tachykinin NK2 receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		44386105	138708	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	621	10	1	4	6.4	CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/0960-894X(96)00148-5
		CHEMBL369498	138708	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	621	10	1	4	6.4	CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/0960-894X(96)00148-5
		44335360	11637	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	608	8	2	4	5.5	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00631-x
		CHEMBL104348	11637	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	608	8	2	4	5.5	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00631-x
		10077113	128321	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		CHEMBL35857	128321	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2	ChEMBL	589	7	2	3	5.4	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1	10.1016/s0960-894x(00)00260-2
		44385575	66570	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	653	11	1	6	5.6	COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/0960-894X(96)00148-5
		CHEMBL172676	66570	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	653	11	1	6	5.6	COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/0960-894X(96)00148-5
		44411637	146058	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells	ChEMBL	441	4	1	3	4.5	O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F	10.1016/j.bmcl.2006.02.027
		CHEMBL379097	146058	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells	ChEMBL	441	4	1	3	4.5	O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F	10.1016/j.bmcl.2006.02.027
		10076881	169695	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	577	5	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1	10.1016/s0960-894x(02)00382-7
		CHEMBL417407	169695	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	577	5	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1	10.1016/s0960-894x(02)00382-7
		10055770	124254	0	None	-	0	Golden hamster	5.3	pIC50	=	5.3	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	734	24	10	10	-1.7	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1021/jm00099a024
		CHEMBL339941	124254	0	None	-	0	Golden hamster	5.3	pIC50	=	5.3	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	734	24	10	10	-1.7	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1021/jm00099a024
		CHEMBL2114443	216034	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O	10.1021/jm00037a009
		44319355	112299	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	605	10	1	6	5.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL312173	112299	0	None	-	0	Mouse	7.2	pIC50	=	7.2	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	605	10	1	6	5.1	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		71450949	86324	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	567	7	2	4	5.6	CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		CHEMBL2114103	86324	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	567	7	2	4	5.6	CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21	10.1016/s0960-894x(98)00395-3
		11790	106263	98	None	-2	4	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	272	1	0	2	4.6	O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12	nan
		CHEMBL283196	106263	98	None	-2	4	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	272	1	0	2	4.6	O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12	nan
		73265456	133228	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	590	4	1	3	5.7	CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	nan
		CHEMBL3651895	133228	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	590	4	1	3	5.7	CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	nan
		71461705	86393	0	None	-	0	Guinea pig	7.2	pIC50	=	7.2	Binding	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane	ChEMBL	672	8	0	7	6.0	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
		CHEMBL2114963	86393	0	None	-	0	Guinea pig	7.2	pIC50	=	7.2	Binding	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane	ChEMBL	672	8	0	7	6.0	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
		9916195	127277	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	576	7	1	4	5.0	CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1	10.1016/s0960-894x(01)00074-9
		CHEMBL354422	127277	3	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand	ChEMBL	576	7	1	4	5.0	CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1	10.1016/s0960-894x(01)00074-9
		CHEMBL126294	215446	19	None	-	0	Golden hamster	8.2	pIC50	=	8.2	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1021/jm00099a024
		44310284	211155	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	465	7	0	4	3.7	O=C(CC1CC1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		CHEMBL71784	211155	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	465	7	0	4	3.7	O=C(CC1CC1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		44310102	211172	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	418	7	0	2	5.7	CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL71918	211172	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	418	7	0	2	5.7	CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		10950925	136432	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	478	7	1	4	3.8	NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL367348	136432	0	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	478	7	1	4	3.8	NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		44309946	210696	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	434	7	1	3	4.7	CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL69065	210696	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	434	7	1	3	4.7	CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		23294208	103923	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	590	8	1	4	6.8	O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1	10.1016/s0960-894x(98)00215-7
		CHEMBL26790	103923	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor	ChEMBL	590	8	1	4	6.8	O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1	10.1016/s0960-894x(98)00215-7
		44310237	110560	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	517	7	0	5	4.2	COc1ccccc1C(=O)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		CHEMBL308901	110560	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	517	7	0	5	4.2	COc1ccccc1C(=O)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		44309945	109844	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	500	8	2	4	4.9	CN(CC(CCN1CCC(O)(c2ncc[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL307338	109844	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	500	8	2	4	4.9	CN(CC(CCN1CCC(O)(c2ncc[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		44310282	210862	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	523	7	0	5	3.7	O=S(=O)(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		CHEMBL70157	210862	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	523	7	0	5	3.7	O=S(=O)(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		10394084	126622	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand	ChEMBL	618	9	1	5	7.4	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc(C2(C(F)(F)F)N=N2)c1	10.1016/0960-894X(96)00075-3
		CHEMBL348599	126622	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand	ChEMBL	618	9	1	5	7.4	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc(C2(C(F)(F)F)N=N2)c1	10.1016/0960-894X(96)00075-3
		44310456	109551	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	485	8	0	5	5.2	CN(CC(CCN1CCC(n2cncn2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL305191	109551	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	485	8	0	5	5.2	CN(CC(CCN1CCC(n2cncn2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		44310433	211139	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	456	8	0	4	5.0	CN(CC(CCN1CC(n2ccnc2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL71704	211139	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	456	8	0	4	5.0	CN(CC(CCN1CC(n2ccnc2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		11498370	107953	0	None	-	0	Guinea pig	8.2	pIC50	=	8.2	Binding	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane	ChEMBL	654	8	1	7	5.7	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
		CHEMBL295615	107953	0	None	-	0	Guinea pig	8.2	pIC50	=	8.2	Binding	The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane	ChEMBL	654	8	1	7	5.7	COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(00)00324-3
		44386231	68154	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	607	8	1	4	6.3	COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C	10.1016/0960-894X(96)00148-5
		CHEMBL176951	68154	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	607	8	1	4	6.3	COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C	10.1016/0960-894X(96)00148-5
		44335372	11546	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	605	7	2	3	5.9	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00631-x
		CHEMBL103979	11546	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	605	7	2	3	5.9	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00631-x
		CHEMBL2372517	217045	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O	10.1021/jm00037a009
		3198	212292	76	None	-21	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	212292	76	None	-21	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	212292	76	None	-21	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		138106885	173690	75	None	-1	4	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
		36314	173690	75	None	-1	4	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
		CHEMBL428647	173690	75	None	-1	4	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
		44291788	108189	0	None	-	0	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand	ChEMBL	553	16	4	5	4.7	CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO	10.1016/S0960-894X(00)80360-1
		CHEMBL297327	108189	0	None	-	0	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand	ChEMBL	553	16	4	5	4.7	CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO	10.1016/S0960-894X(00)80360-1
		44291015	108004	2	None	-	0	Golden hamster	5.2	pIC50	=	5.2	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	553	16	4	5	4.7	CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@](C)(Cc1ccccc1)C(=O)NCCCCCCCCO	10.1021/jm950892r
		CHEMBL296014	108004	2	None	-	0	Golden hamster	5.2	pIC50	=	5.2	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	553	16	4	5	4.7	CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@](C)(Cc1ccccc1)C(=O)NCCCCCCCCO	10.1021/jm950892r
		441243	16608	58	None	-19	8	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	nan
		CHEMBL114	16608	58	None	-19	8	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	nan
		CHEMBL307433	217759	0	None	-	0	Golden hamster	6.2	pIC50	=	6.2	Binding	Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder	ChEMBL		None	None	None		CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O	10.1016/0960-894X(94)85022-4
		10055415	113533	0	None	-	3	Human	7.2	pIC50	=	7.2	Binding	Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	688	12	4	5	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144352	113533	0	None	-	3	Human	7.2	pIC50	=	7.2	Binding	Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	688	12	4	5	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		10055415	113533	0	None	-	3	Rat	7.2	pIC50	=	7.2	Binding	Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	688	12	4	5	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144352	113533	0	None	-	3	Rat	7.2	pIC50	=	7.2	Binding	Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	688	12	4	5	3.2	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		2125	9804	2	None	-	1	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand	ChEMBL	581	16	5	5	4.0	NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C	10.1016/S0960-894X(00)80360-1
		5311350	9804	2	None	-	1	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand	ChEMBL	581	16	5	5	4.0	NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C	10.1016/S0960-894X(00)80360-1
		CHEMBL444832	9804	2	None	-	1	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand	ChEMBL	581	16	5	5	4.0	NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C	10.1016/S0960-894X(00)80360-1
		2125	9804	2	None	-	1	Golden hamster	5.2	pIC50	=	5.2	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	581	16	5	5	4.0	NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C	10.1021/jm950892r
		5311350	9804	2	None	-	1	Golden hamster	5.2	pIC50	=	5.2	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	581	16	5	5	4.0	NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C	10.1021/jm950892r
		CHEMBL444832	9804	2	None	-	1	Golden hamster	5.2	pIC50	=	5.2	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	581	16	5	5	4.0	NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C	10.1021/jm950892r
		44335318	11877	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	603	8	2	3	5.9	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1	10.1016/s0960-894x(01)00631-x
		CHEMBL105600	11877	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand	ChEMBL	603	8	2	3	5.9	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1	10.1016/s0960-894x(01)00631-x
		49863733	22104	0	None	-2	4	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1477	21	11	14	6.8	CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm100157m
		CHEMBL1214026	22104	0	None	-2	4	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1477	21	11	14	6.8	CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm100157m
		CHEMBL410808	219622	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O	10.1021/jm00037a009
		657255	205863	34	None	-17	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	205863	34	None	-17	15	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL405422	219340	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O	10.1021/jm00037a009
		3040489	51335	2	None	-	0	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uM	ChEMBL	318	4	1	2	3.8	O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12	10.1016/0960-894X(94)80030-8
		CHEMBL151990	51335	2	None	-	0	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uM	ChEMBL	318	4	1	2	3.8	O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12	10.1016/0960-894X(94)80030-8
		CHEMBL264353	217397	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O	10.1021/jm00037a009
		44366600	49706	0	None	-	0	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uM	ChEMBL	360	5	1	2	3.8	O=C1CCN(C(=O)CCc2c[nH]c3ccccc23)CC1Cc1ccccc1	10.1016/0960-894X(94)80030-8
		CHEMBL150346	49706	0	None	-	0	Golden hamster	5.2	pIC50	=	5.2	Binding	Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uM	ChEMBL	360	5	1	2	3.8	O=C1CCN(C(=O)CCc2c[nH]c3ccccc23)CC1Cc1ccccc1	10.1016/0960-894X(94)80030-8
		135449286	199968	2	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	502	6	2	5	4.3	O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1	10.1021/jm950654w
		CHEMBL52330	199968	2	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	502	6	2	5	4.3	O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1	10.1021/jm950654w
		44212285	130596	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	549	7	1	3	5.7	NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1	10.1016/0960-894X(96)00148-5
		CHEMBL362394	130596	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	549	7	1	3	5.7	NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1	10.1016/0960-894X(96)00148-5
		73265450	133220	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	680	4	0	3	7.2	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		CHEMBL3651887	133220	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	680	4	0	3	7.2	CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1	nan
		87318292	133230	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	616	4	0	3	5.6	CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1	nan
		CHEMBL3651897	133230	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	616	4	0	3	5.6	CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1	nan
		44310105	211081	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	550	8	1	5	6.6	CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL71394	211081	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	550	8	1	5	6.6	CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		44310432	211132	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	473	6	0	4	3.8	O=C(c1ccccc1)N1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		CHEMBL71644	211132	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	473	6	0	4	3.8	O=C(c1ccccc1)N1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		44310150	109485	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	534	8	1	3	7.0	CN(CC(CCN1CCC(c2nc3ccccc3[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL304807	109485	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	534	8	1	3	7.0	CN(CC(CCN1CCC(c2nc3ccccc3[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		44310262	211052	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	536	8	1	5	6.2	CN(CC(CCN1CCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL71226	211052	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	536	8	1	5	6.2	CN(CC(CCN1CCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		44310238	210823	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	487	6	0	4	4.2	O=C(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		CHEMBL69889	210823	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	487	6	0	4	4.2	O=C(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(03)00343-3
		44310165	210673	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	484	8	0	4	5.8	CN(CC(CCN1CCC(n2ccnc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL68917	210673	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	484	8	0	4	5.8	CN(CC(CCN1CCC(n2ccnc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		10005190	211133	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	475	8	0	4	4.3	CN(CC(CCN1CC(N2CCOCC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL71647	211133	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	475	8	0	4	4.3	CN(CC(CCN1CC(N2CCOCC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		44319323	20519	0	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL1195230	20519	0	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL554092	20519	0	None	-	0	Mouse	8.1	pIC50	=	8.1	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	640	10	1	7	5.1	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		9807403	73458	0	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	542	8	0	5	2.9	CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL185452	73458	0	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	542	8	0	5	2.9	CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1	10.1016/j.bmcl.2005.05.134
		44392347	128906	0	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	543	7	0	4	5.1	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL359655	128906	0	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	543	7	0	4	5.1	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1	10.1016/j.bmcl.2005.05.134
		71449143	86295	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	611	5	2	3	6.7	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1	10.1016/s0960-894x(02)00382-7
		CHEMBL2113740	86295	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2	ChEMBL	611	5	2	3	6.7	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1	10.1016/s0960-894x(02)00382-7
		CHEMBL2371928	216933	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity to NK2 receptorBinding affinity to NK2 receptor	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC(=O)NC(=O)N1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1016/j.bmcl.2006.07.036
		25028925	98140	4	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	570	5	1	5	5.5	Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21	10.1021/jm400751p
		CHEMBL2402572	98140	4	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	570	5	1	5	5.5	Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21	10.1021/jm400751p
		CHEMBL2369630	216424	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.	ChEMBL		None	None	None		C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O	10.1021/jm000316h
		44212283	66633	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	593	9	1	4	5.6	COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/0960-894X(96)00148-5
		CHEMBL172915	66633	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	593	9	1	4	5.6	COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1	10.1016/0960-894X(96)00148-5
		44319356	111148	0	None	-	0	Mouse	7.1	pIC50	=	7.1	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	607	10	1	6	4.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL310173	111148	0	None	-	0	Mouse	7.1	pIC50	=	7.1	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	607	10	1	6	4.7	COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		73265457	133229	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	653	4	0	4	4.5	CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	nan
		CHEMBL3651896	133229	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.	ChEMBL	653	4	0	4	4.5	CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1	nan
		10439730	113534	0	None	-	3	Human	7.1	pIC50	=	7.1	Binding	Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	702	12	3	6	3.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		CHEMBL3144353	113534	0	None	-	3	Human	7.1	pIC50	=	7.1	Binding	Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	702	12	3	6	3.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O	10.1021/jm00063a015
		10972666	129724	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	465	7	0	4	3.7	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1	10.1016/j.bmcl.2005.05.134
		CHEMBL360721	129724	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor	ChEMBL	465	7	0	4	3.7	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1	10.1016/j.bmcl.2005.05.134
		9915428	180412	3	None	-	0	Golden hamster	6.1	pIC50	=	6.1	Binding	Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand	ChEMBL	546	15	4	4	5.1	CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1	10.1016/0960-894X(95)00313-I
		CHEMBL45340	180412	3	None	-	0	Golden hamster	6.1	pIC50	=	6.1	Binding	Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand	ChEMBL	546	15	4	4	5.1	CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1	10.1016/0960-894X(95)00313-I
		9915428	180412	3	None	-	0	Golden hamster	6.1	pIC50	=	6.1	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	546	15	4	4	5.1	CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1	10.1021/jm950892r
		CHEMBL45340	180412	3	None	-	0	Golden hamster	6.1	pIC50	=	6.1	Binding	Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA	ChEMBL	546	15	4	4	5.1	CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1	10.1021/jm950892r
		44310151	109555	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	534	8	0	4	6.9	CN(CC(CCN1CCC(n2cnc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL305236	109555	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	534	8	0	4	6.9	CN(CC(CCN1CCC(n2cnc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		153996	119445	2	None	-3	3	Human	8.1	pIC50	=	8.1	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/0960-894X(96)00148-5
		CHEMBL330366	119445	2	None	-3	3	Human	8.1	pIC50	=	8.1	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/0960-894X(96)00148-5
		CHEMBL539021	119445	2	None	-3	3	Human	8.1	pIC50	=	8.1	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/0960-894X(96)00148-5
		153996	119445	2	None	-	3	Mouse	8.1	pIC50	=	8.1	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL330366	119445	2	None	-	3	Mouse	8.1	pIC50	=	8.1	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL539021	119445	2	None	-	3	Mouse	8.1	pIC50	=	8.1	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		44310139	211489	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	564	8	1	5	7.0	CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL74127	211489	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	564	8	1	5	7.0	CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		9831309	142042	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1021/jm058225d
		CHEMBL372587	142042	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1021/jm058225d
		21831101	210600	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	550	8	1	5	6.6	CN(CC(CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL68440	210600	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	550	8	1	5	6.6	CN(CC(CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		18964186	211083	0	None	-	3	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	510	8	1	3	6.2	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		CHEMBL71397	211083	0	None	-	3	Human	8.1	pIC50	=	8.1	Binding	Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand	ChEMBL	510	8	1	3	6.2	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(03)00343-3
		9850582	204021	22	None	-1	6	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cellsBinding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(03)00343-3
		CHEMBL56835	204021	22	None	-1	6	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cellsBinding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(03)00343-3
		21121353	108250	0	None	-	3	Rat	6.1	pIC50	=	6.1	Binding	Tested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	625	14	4	7	2.0	CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	10.1021/jm00063a015
		CHEMBL297776	108250	0	None	-	3	Rat	6.1	pIC50	=	6.1	Binding	Tested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	625	14	4	7	2.0	CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	10.1021/jm00063a015
		CHEMBL2369631	216425	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.	ChEMBL		None	None	None		C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O	10.1021/jm000316h
		2683	109665	25	None	-398	16	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	109665	25	None	-398	16	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	109665	25	None	-398	16	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		579	9918	18	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to NK2 receptorBinding affinity to NK2 receptor	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.036
		6918468	9918	18	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to NK2 receptorBinding affinity to NK2 receptor	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.036
		CHEMBL41547	9918	18	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to NK2 receptorBinding affinity to NK2 receptor	ChEMBL		None	None	None		None	10.1016/j.bmcl.2006.07.036
		10259606	124887	0	None	-	0	Golden hamster	8.1	pIC50	=	8.1	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	768	24	10	10	-1.5	CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		CHEMBL340743	124887	0	None	-	0	Golden hamster	8.1	pIC50	=	8.1	Binding	Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2	ChEMBL	768	24	10	10	-1.5	CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C	10.1021/jm00099a024
		CHEMBL263852	217372	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O	10.1021/jm00037a009
		CHEMBL2390989	217190	16	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1016/j.ejmech.2013.01.044
		44319340	212692	0	None	-	0	Mouse	8.0	pIC50	=	8.0	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	707	10	0	6	7.2	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		CHEMBL84055	212692	0	None	-	0	Mouse	8.0	pIC50	=	8.0	Binding	Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.	ChEMBL	707	10	0	6	7.2	COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/S0960-894X(97)10013-0
		44312000	211458	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	551	8	3	3	4.6	CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL73839	211458	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined	ChEMBL	551	8	3	3	4.6	CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1	10.1016/s0960-894x(98)00395-3
		CHEMBL265573	217433	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O	10.1021/jm00037a009
		448537	167029	89	None	-26	25	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	167029	89	None	-26	25	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		44384678	68145	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	697	11	1	8	6.2	CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC	10.1016/0960-894X(96)00148-5
		CHEMBL176860	68145	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA	ChEMBL	697	11	1	8	6.2	CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC	10.1016/0960-894X(96)00148-5
		21121353	108250	0	None	-	3	Human	7.0	pIC50	=	7	Binding	Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	625	14	4	7	2.0	CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	10.1021/jm00063a015
		CHEMBL297776	108250	0	None	-	3	Human	7.0	pIC50	=	7	Binding	Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand	ChEMBL	625	14	4	7	2.0	CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O	10.1021/jm00063a015
		44270502	62027	0	None	-	1	Rat	9.7	pKd	=	9.7	Binding	pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens	ChEMBL	714	6	8	7	-0.3	CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1016/s0960-894x(98)00178-4
		CHEMBL16180	62027	0	None	-	1	Rat	9.7	pKd	=	9.7	Binding	pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens	ChEMBL	714	6	8	7	-0.3	CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1016/s0960-894x(98)00178-4
		118718707	122158	0	None	-	1	Rat	6.0	pKd	=	6	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	843	12	8	9	0.3	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3350012	122158	0	None	-	1	Rat	6.0	pKd	=	6	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	843	12	8	9	0.3	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		118718415	122129	0	None	-2	2	Rat	5.0	pKd	=	5	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	820	12	8	10	-0.5	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349511	122129	0	None	-2	2	Rat	5.0	pKd	=	5	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	820	12	8	10	-0.5	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		118718693	122154	0	None	-	1	Rat	5.0	pKd	=	5	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	843	12	8	9	0.3	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349994	122154	0	None	-	1	Rat	5.0	pKd	=	5	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	843	12	8	9	0.3	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		118718709	122159	0	None	-	1	Rat	5.0	pKd	=	5	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	726	8	5	7	2.5	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3350016	122159	0	None	-	1	Rat	5.0	pKd	=	5	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	726	8	5	7	2.5	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		118718515	122138	0	None	-	1	Rat	4.9	pKd	=	4.9	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	786	12	7	8	1.2	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349686	122138	0	None	-	1	Rat	4.9	pKd	=	4.9	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	786	12	7	8	1.2	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		118718571	122145	0	None	-	1	Rat	4.8	pKd	=	4.8	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	747	12	6	8	0.7	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349799	122145	0	None	-	1	Rat	4.8	pKd	=	4.8	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	747	12	6	8	0.7	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349619	218224	0	None	-	1	Rat	4.8	pKd	=	4.8	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/jm00053a001
		118718570	122144	0	None	63	2	Rat	6.7	pKd	=	6.7	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	786	12	7	8	1.2	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349798	122144	0	None	63	2	Rat	6.7	pKd	=	6.7	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	786	12	7	8	1.2	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349990	218243	0	None	-	1	Rat	4.7	pKd	=	4.7	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/jm00053a001
		118718513	122137	0	None	-	1	Rat	5.6	pKd	=	5.6	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	797	11	6	8	2.2	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349683	122137	0	None	-	1	Rat	5.6	pKd	=	5.6	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	797	11	6	8	2.2	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		118718694	122155	0	None	-	1	Rat	4.6	pKd	=	4.6	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	804	12	7	9	-0.2	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349995	122155	0	None	-	1	Rat	4.6	pKd	=	4.6	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	804	12	7	9	-0.2	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O	10.1021/jm00053a001
		118718517	122140	0	None	-1	3	Rat	6.4	pKd	=	6.4	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	800	12	6	8	1.5	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		CHEMBL3349688	122140	0	None	-1	3	Rat	6.4	pKd	=	6.4	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	800	12	6	8	1.5	CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O	10.1021/jm00053a001
		44270503	105554	0	None	-	1	Rat	8.3	pKd	=	8.3	Binding	pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens	ChEMBL	908	10	12	13	-2.8	CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1016/s0960-894x(98)00178-4
		CHEMBL278223	105554	0	None	-	1	Rat	8.3	pKd	=	8.3	Binding	pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens	ChEMBL	908	10	12	13	-2.8	CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1016/s0960-894x(98)00178-4
		CHEMBL334721	218178	1	None	-9	3	Rat	8.2	pKd	=	8.2	Binding	pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1016/s0960-894x(98)00178-4
		CHEMBL3349531	218204	0	None	-	1	Rat	6.2	pKd	=	6.2	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/jm00053a001
		CHEMBL3349620	218225	11	None	251	3	Rat	8.1	pKd	=	8.1	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O	10.1021/jm00053a001
		118718516	122139	0	None	-79	3	Rat	5.1	pKd	=	5.1	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	1599	27	12	16	2.8	CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O	10.1021/jm00053a001
		CHEMBL3349687	122139	0	None	-79	3	Rat	5.1	pKd	=	5.1	Binding	Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens	ChEMBL	1599	27	12	16	2.8	CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O	10.1021/jm00053a001
		9831504	91811	0	None	-	1	Human	10.6	pKi	=	10.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	696	8	6	6	2.0	O=C1C[C@@H](NC2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL224081	91811	0	None	-	1	Human	10.6	pKi	=	10.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	696	8	6	6	2.0	O=C1C[C@@H](NC2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		71449111	85670	0	None	6	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	759	8	5	6	3.3	O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		CHEMBL2112922	85670	0	None	6	2	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	759	8	5	6	3.3	O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		44421489	175507	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	742	9	7	7	0.8	NS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL436981	175507	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	742	9	7	7	0.8	NS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		11433617	13543	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	12	2	6	5.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083850	13543	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	12	2	6	5.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		23625329	99594	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	664	11	3	6	5.6	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Cl)cc2s1	10.1021/jm070289w
		CHEMBL243711	99594	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	664	11	3	6	5.6	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Cl)cc2s1	10.1021/jm070289w
		11593070	99944	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	708	11	3	6	5.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Br)cc2s1	10.1021/jm070289w
		CHEMBL244362	99944	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	708	11	3	6	5.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Br)cc2s1	10.1021/jm070289w
		23627059	157955	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	698	11	3	6	5.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(C(F)(F)F)cc2s1	10.1021/jm070289w
		CHEMBL395972	157955	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	698	11	3	6	5.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(C(F)(F)F)cc2s1	10.1021/jm070289w
		11366268	148783	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	8	6	6	2.3	O=C1C[C@@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL387506	148783	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	8	6	6	2.3	O=C1C[C@@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		44421488	175789	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	741	9	6	7	1.6	CS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL439281	175789	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	741	9	6	7	1.6	CS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		11527495	8749	19	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	644	11	3	6	5.2	O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1	10.1021/jm070289w
		2117	8749	19	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	644	11	3	6	5.2	O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1	10.1021/jm070289w
		CHEMBL266125	8749	19	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	644	11	3	6	5.2	O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1	10.1021/jm070289w
		DB12042	8749	19	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	644	11	3	6	5.2	O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1	10.1021/jm070289w
		46889641	13551	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	602	10	2	6	5.2	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083858	13551	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	602	10	2	6	5.2	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237033	20970	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	359	7	1	4	1.9	N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1	10.1021/jm100176s
		CHEMBL1083974	20970	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	359	7	1	4	1.9	N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1	10.1021/jm100176s
		CHEMBL1198853	20970	0	None	-	1	Human	10.1	pKi	=	10.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	359	7	1	4	1.9	N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1	10.1021/jm100176s
		23627061	157960	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	701	14	3	7	5.8	CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1	10.1021/jm070289w
		CHEMBL395974	157960	0	None	-	1	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	701	14	3	7	5.8	CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1	10.1021/jm070289w
		2115	8628	19	None	8	3	Rat	10.0	pKi	=	10	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	10.1016/S0960-894X(01)80541-2
		9953599	8628	19	None	8	3	Rat	10.0	pKi	=	10	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	10.1016/S0960-894X(01)80541-2
		CHEMBL2110370	8628	19	None	8	3	Rat	10.0	pKi	=	10	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	10.1016/S0960-894X(01)80541-2
		10508281	91558	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	633	6	5	4	3.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1	10.1021/jm0010217
		CHEMBL223221	91558	0	None	-	1	Human	10.0	pKi	=	10	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	633	6	5	4	3.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1	10.1021/jm0010217
		10508281	91558	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	633	6	5	4	3.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1	10.1021/jm040832y
		CHEMBL223221	91558	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	633	6	5	4	3.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1	10.1021/jm040832y
		11239751	91946	0	None	1995	3	Human	10.0	pKi	=	10	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	785	10	7	8	-0.5	NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL225297	91946	0	None	1995	3	Human	10.0	pKi	=	10	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	785	10	7	8	-0.5	NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		11193639	149834	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	680	8	6	6	3.0	O=C1C[C@@H](NC2CCSCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL389510	149834	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	680	8	6	6	3.0	O=C1C[C@@H](NC2CCSCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11445137	13572	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	644	11	2	6	5.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083879	13572	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	644	11	2	6	5.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		10508281	91558	0	None	-	1	Human	10.0	pKi	=	10	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	633	6	5	4	3.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1	10.1021/jm011127h
		CHEMBL223221	91558	0	None	-	1	Human	10.0	pKi	=	10	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	633	6	5	4	3.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1	10.1021/jm011127h
		10122346	99008	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	652	11	3	7	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(c3ccccn3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL242626	99008	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	652	11	3	7	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(c3ccccn3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		71452717	85673	0	None	5	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	678	7	5	6	1.6	O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		CHEMBL2112925	85673	0	None	5	2	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	678	7	5	6	1.6	O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		11388737	91803	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	691	7	5	6	1.7	CC(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL224003	91803	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	691	7	5	6	1.7	CC(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		11764349	91841	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	721	9	7	7	1.1	O=C1C[C@@H](NC(=O)CN2CCC(O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL224374	91841	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	721	9	7	7	1.1	O=C1C[C@@H](NC(=O)CN2CCC(O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		46236920	13556	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	629	12	2	5	7.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083863	13556	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	629	12	2	5	7.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237170	13562	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	640	12	2	5	6.7	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccc(F)cc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083869	13562	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	640	12	2	5	6.7	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccc(F)cc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		23626110	156485	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	640	12	4	7	2.0	NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1	10.1021/jm070289w
		CHEMBL394780	156485	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	640	12	4	7	2.0	NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1	10.1021/jm070289w
		23627060	157957	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	660	12	3	7	4.9	COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1	10.1021/jm070289w
		CHEMBL395973	157957	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	660	12	3	7	4.9	COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1	10.1021/jm070289w
		44302816	207144	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	903	20	7	8	2.4	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		CHEMBL59780	207144	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	903	20	7	8	2.4	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		5487475	96168	29	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	903	20	7	8	2.4	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		CHEMBL2370064	96168	29	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	903	20	7	8	2.4	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		9853827	91996	0	None	794	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	790	10	6	8	1.5	O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL225588	91996	0	None	794	3	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	790	10	6	8	1.5	O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11216552	103737	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	678	8	5	6	2.7	CN(C1CCOCC1)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm040832y
		CHEMBL266284	103737	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	678	8	5	6	2.7	CN(C1CCOCC1)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm040832y
		10326920	149777	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	650	7	5	6	1.9	O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL389459	149777	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	650	7	5	6	1.9	O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11411829	149835	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	712	8	6	7	1.7	O=C1C[C@@H](NC2CCS(=O)(=O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL389511	149835	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	712	8	6	7	1.7	O=C1C[C@@H](NC2CCS(=O)(=O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11228042	168515	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	648	6	6	5	2.8	N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O	10.1021/jm040832y
		CHEMBL413715	168515	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	648	6	6	5	2.8	N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O	10.1021/jm040832y
		46237171	13563	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	623	12	2	6	6.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083870	13563	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	623	12	2	6	6.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237301	13566	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	628	12	2	6	6.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccs5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083873	13566	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	628	12	2	6	6.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccs5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237302	13567	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	628	12	2	6	6.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccsc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083874	13567	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	628	12	2	6	6.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccsc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237445	13568	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	612	12	2	6	6.2	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccoc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083875	13568	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	612	12	2	6	6.2	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccoc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		10326920	149777	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	650	7	5	6	1.9	O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL389459	149777	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	650	7	5	6	1.9	O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		11205343	91805	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	731	8	5	6	3.5	O=C1C[C@@H](N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL224009	91805	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	731	8	5	6	3.5	O=C1C[C@@H](N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11285709	91961	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	648	6	6	5	2.8	N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O	10.1021/jm040832y
		CHEMBL225392	91961	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	648	6	6	5	2.8	N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O	10.1021/jm040832y
		44421490	149119	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	677	8	6	6	2.2	CN1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL388626	149119	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	677	8	6	6	2.2	CN1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		11228450	149564	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	733	8	5	7	2.3	O=C1C[C@@H](N2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL389279	149564	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	733	8	5	7	2.3	O=C1C[C@@H](N2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		9831546	211954	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	698	12	1	6	5.6	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL78284	211954	0	None	1	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	698	12	1	6	5.6	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44307820	210414	0	None	1	2	Guinea pig	9.7	pKi	=	9.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL67171	210414	0	None	1	2	Guinea pig	9.7	pKi	=	9.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		23626743	99349	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	630	11	3	6	4.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL243496	99349	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	630	11	3	6	4.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		53318867	65257	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	639	12	3	6	4.5	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1	10.1016/j.bmcl.2011.01.074
		CHEMBL1683146	65257	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	639	12	3	6	4.5	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1	10.1016/j.bmcl.2011.01.074
		23627058	157953	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	648	11	3	6	5.1	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(F)cc2s1	10.1021/jm070289w
		CHEMBL395971	157953	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	648	11	3	6	5.1	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(F)cc2s1	10.1021/jm070289w
		11205157	91851	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	718	7	5	6	3.2	O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL224494	91851	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	718	7	5	6	3.2	O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11491634	178324	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	822	10	6	8	1.2	O=C1C[C@@H](NC(=O)CN2CCC(N3CC[S+]([O-])CC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL446450	178324	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	822	10	6	8	1.2	O=C1C[C@@H](NC(=O)CN2CCC(N3CC[S+]([O-])CC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		46238093	13539	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	634	12	2	6	5.7	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2cc(Cl)ccc2o1	10.1021/jm100176s
		CHEMBL1083846	13539	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	634	12	2	6	5.7	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2cc(Cl)ccc2o1	10.1021/jm100176s
		46236387	13542	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	616	12	2	6	5.5	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2s1	10.1021/jm100176s
		CHEMBL1083849	13542	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	616	12	2	6	5.5	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2s1	10.1021/jm100176s
		46237038	13559	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	616	11	2	6	5.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083866	13559	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	616	11	2	6	5.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237300	13565	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	623	12	2	6	6.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccncc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083872	13565	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	623	12	2	6	6.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccncc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		10232332	99975	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccc(Cl)cc2s1	10.1021/jm070289w
		CHEMBL244566	99975	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccc(Cl)cc2s1	10.1021/jm070289w
		44307819	109373	0	None	-1	2	Guinea pig	9.5	pKi	=	9.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL304106	109373	0	None	-1	2	Guinea pig	9.5	pKi	=	9.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		44307677	176043	0	None	1	2	Guinea pig	9.5	pKi	=	9.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL441252	176043	0	None	1	2	Guinea pig	9.5	pKi	=	9.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		44307757	210315	0	None	-1	2	Guinea pig	9.5	pKi	=	9.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL66441	210315	0	None	-1	2	Guinea pig	9.5	pKi	=	9.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		44307758	210335	0	None	-1	2	Guinea pig	9.5	pKi	=	9.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL66635	210335	0	None	-1	2	Guinea pig	9.5	pKi	=	9.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		44383850	66712	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	552	9	0	4	6.8	CC(=O)OC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/S0960-894X(00)80694-0
		CHEMBL173203	66712	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	552	9	0	4	6.8	CC(=O)OC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/S0960-894X(00)80694-0
		44385292	138166	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	572	10	0	5	7.2	CCN(CC(CCN1CCC(OC(C)=O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1	10.1016/S0960-894X(00)80694-0
		CHEMBL368995	138166	0	None	-	1	Rat	9.5	pKi	=	9.5	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	572	10	0	5	7.2	CCN(CC(CCN1CCC(OC(C)=O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1	10.1016/S0960-894X(00)80694-0
		2115	8628	19	None	-8	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells	ChEMBL	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	10.1016/S0960-894X(01)80541-2
		9953599	8628	19	None	-8	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells	ChEMBL	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	10.1016/S0960-894X(01)80541-2
		CHEMBL2110370	8628	19	None	-8	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells	ChEMBL	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	10.1016/S0960-894X(01)80541-2
		44301859	206591	0	None	35481	2	Rat	9.5	pKi	=	9.5	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400	6	2	3	3.5	[O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		CHEMBL59413	206591	0	None	35481	2	Rat	9.5	pKi	=	9.5	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400	6	2	3	3.5	[O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		44577911	179032	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	12	3	5	5.7	Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL447439	179032	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	12	3	5	5.7	Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1	10.1016/j.bmcl.2008.06.102
		25071640	181178	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	634	12	3	5	4.8	O=C(/C=C/c1cccc(Cl)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL455238	181178	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	634	12	3	5	4.8	O=C(/C=C/c1cccc(Cl)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		71449111	85670	0	None	6	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	759	8	5	6	3.3	O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		CHEMBL2112922	85670	0	None	6	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	759	8	5	6	3.3	O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		11193706	17287	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	707	9	6	7	1.0	O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL116812	17287	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	707	9	6	7	1.0	O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11251435	91846	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	721	10	7	7	1.1	O=C1C[C@@H](NC(=O)CN2CCC[C@H]2CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL224426	91846	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	721	10	7	7	1.1	O=C1C[C@@H](NC(=O)CN2CCC[C@H]2CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11400251	150638	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	739	9	6	7	0.7	O=C1C[C@@H](NC(=O)CN2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL390168	150638	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	739	9	6	7	0.7	O=C1C[C@@H](NC(=O)CN2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		46237960	13465	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	610	12	2	5	5.4	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1	10.1021/jm100176s
		CHEMBL1083561	13465	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	610	12	2	5	5.4	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1	10.1021/jm100176s
		46889640	13548	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	11	2	6	5.9	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083855	13548	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	11	2	6	5.9	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237299	13564	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	623	12	2	6	6.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccnc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083871	13564	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	623	12	2	6	6.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccnc5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46236394	13570	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	628	12	2	9	4.1	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5nnn(C)n5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083877	13570	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	628	12	2	9	4.1	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5nnn(C)n5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46236396	13571	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	618	15	2	6	5.8	CCOCCCN1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1	10.1021/jm100176s
		CHEMBL1083878	13571	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	618	15	2	6	5.8	CCOCCCN1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1	10.1021/jm100176s
		46236516	13640	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	639	12	2	6	4.2	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1084160	13640	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	639	12	2	6	4.2	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		44577911	179032	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	664	12	3	5	5.7	Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1	10.1021/jm100176s
		CHEMBL447439	179032	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	664	12	3	5	5.7	Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1	10.1021/jm100176s
		11193706	17287	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	707	9	6	7	1.0	O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL116812	17287	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	707	9	6	7	1.0	O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		53324157	65262	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	610	12	2	5	5.4	O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1	10.1016/j.bmcl.2011.01.074
		CHEMBL1683151	65262	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	610	12	2	5	5.4	O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1	10.1016/j.bmcl.2011.01.074
		9961315	124702	0	None	-2	3	Human	9.5	pKi	=	9.5	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cells	ChEMBL	661	10	0	5	7.9	COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1	10.1021/jm020094i
		CHEMBL340326	124702	0	None	-2	3	Human	9.5	pKi	=	9.5	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cells	ChEMBL	661	10	0	5	7.9	COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1	10.1021/jm020094i
		23626900	157962	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cccc(Cl)c2s1	10.1021/jm070289w
		CHEMBL395975	157962	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cccc(Cl)c2s1	10.1021/jm070289w
		44434191	156615	0	None	501	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	588	11	3	5	5.4	CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL394889	156615	0	None	501	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	588	11	3	5	5.4	CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		11274473	91800	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	744	13	11	10	-1.4	O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL223993	91800	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	744	13	11	10	-1.4	O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		10876489	91979	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	788	10	6	7	2.6	O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL225475	91979	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	788	10	6	7	2.6	O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11331994	175801	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	663	7	5	6	1.8	CN1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL439377	175801	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	663	7	5	6	1.8	CN1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		46238232	13541	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	614	12	2	6	5.3	Cc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1	10.1021/jm100176s
		CHEMBL1083848	13541	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	614	12	2	6	5.3	Cc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1	10.1021/jm100176s
		46236510	13573	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	639	11	2	6	5.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)c5cccn5C)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083880	13573	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	639	11	2	6	5.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)c5cccn5C)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46236512	13638	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	645	10	2	6	4.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1084158	13638	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	645	10	2	6	4.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		44343142	162638	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	788	10	6	7	2.6	O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL406024	162638	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	788	10	6	7	2.6	O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		2106	10319	4	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	711	12	1	6	6.4	CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C	10.1016/s0960-894x(02)00462-6
		9875034	10319	4	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	711	12	1	6	6.4	CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C	10.1016/s0960-894x(02)00462-6
		CHEMBL77023	10319	4	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	711	12	1	6	6.4	CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C	10.1016/s0960-894x(02)00462-6
		9810544	211571	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	726	12	1	6	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL74956	211571	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	726	12	1	6	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		155551678	182211	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes	ChEMBL	697	12	1	6	6.9	CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1	10.1021/acs.jmedchem.9b00017
		CHEMBL4576324	182211	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes	ChEMBL	697	12	1	6	6.9	CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1	10.1021/acs.jmedchem.9b00017
		44307898	208252	0	None	1	2	Guinea pig	9.4	pKi	=	9.4	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL60504	208252	0	None	1	2	Guinea pig	9.4	pKi	=	9.4	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		44307679	210296	0	None	1	2	Guinea pig	9.4	pKi	=	9.4	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
		CHEMBL66332	210296	0	None	1	2	Guinea pig	9.4	pKi	=	9.4	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
		23625950	149659	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	578	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCSCC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL389355	149659	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	578	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCSCC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		104974	10248	31	None	-1	7	Bovine	9.3	pKi	=	9.3	Binding	Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/j.bmcl.2004.06.053
		2111	10248	31	None	-1	7	Bovine	9.3	pKi	=	9.3	Binding	Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/j.bmcl.2004.06.053
		3481	10248	31	None	-1	7	Bovine	9.3	pKi	=	9.3	Binding	Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/j.bmcl.2004.06.053
		CHEMBL308148	10248	31	None	-1	7	Bovine	9.3	pKi	=	9.3	Binding	Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/j.bmcl.2004.06.053
		DB06660	10248	31	None	-1	7	Bovine	9.3	pKi	=	9.3	Binding	Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/j.bmcl.2004.06.053
		44315483	103374	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	728	13	2	7	5.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL263243	103374	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	728	13	2	7	5.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		9831707	211806	0	None	1	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	718	11	0	6	7.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL76965	211806	0	None	1	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	718	11	0	6	7.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		9853636	212229	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	762	14	1	7	5.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL80355	212229	0	None	-1	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	762	14	1	7	5.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		102023780	127525	0	None	-1	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	3	7	6.4	CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		10417302	127525	0	None	-1	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	3	7	6.4	CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44380072	127525	0	None	-1	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	3	7	6.4	CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL355041	127525	0	None	-1	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	3	7	6.4	CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		104974	10248	31	None	1	7	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(00)00463-7
		2111	10248	31	None	1	7	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(00)00463-7
		3481	10248	31	None	1	7	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(00)00463-7
		CHEMBL308148	10248	31	None	1	7	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(00)00463-7
		DB06660	10248	31	None	1	7	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/s0960-894x(00)00463-7
		104974	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		2111	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		3481	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		CHEMBL308148	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		DB06660	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		9843958	207572	1	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400	6	2	3	3.5	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		CHEMBL60064	207572	1	None	-	1	Rat	9.3	pKi	=	9.3	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400	6	2	3	3.5	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		44577907	179230	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	614	12	3	5	4.4	Cc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL447971	179230	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	614	12	3	5	4.4	Cc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		44421494	148786	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	1068	19	17	20	-5.8	O=C1C[C@@H](NC[C@H](O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL387542	148786	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	1068	19	17	20	-5.8	O=C1C[C@@H](NC[C@H](O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11468591	150636	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	748	10	7	7	0.9	NC(=O)C1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL390167	150636	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	748	10	7	7	0.9	NC(=O)C1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		46237957	13464	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	636	13	2	5	5.9	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc(-c2ccccc2)cc1	10.1021/jm100176s
		CHEMBL1083560	13464	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	636	13	2	5	5.9	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc(-c2ccccc2)cc1	10.1021/jm100176s
		46236647	13547	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	616	11	2	6	5.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083854	13547	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	616	11	2	6	5.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46236798	13554	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	628	11	2	6	5.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](/C=C/CN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083861	13554	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	628	11	2	6	5.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](/C=C/CN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		11239162	13558	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	645	13	2	6	6.5	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083865	13558	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	645	13	2	6	6.5	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46236514	13639	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	681	12	2	7	4.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1084159	13639	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	681	12	2	7	4.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46236655	13642	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	638	12	2	6	5.1	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)C(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1084162	13642	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	638	12	2	6	5.1	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)C(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		2110	9743	38	None	-1	6	Rat	9.3	pKi	=	9.3	Binding	Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		219077	9743	38	None	-1	6	Rat	9.3	pKi	=	9.3	Binding	Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		3480	9743	38	None	-1	6	Rat	9.3	pKi	=	9.3	Binding	Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		CHEMBL346178	9743	38	None	-1	6	Rat	9.3	pKi	=	9.3	Binding	Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		DB04872	9743	38	None	-1	6	Rat	9.3	pKi	=	9.3	Binding	Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		23626744	99352	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	616	10	3	6	4.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL243498	99352	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	616	10	3	6	4.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		2109	10909	4	None	-5	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells	ChEMBL	631	9	0	4	7.9	N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C	10.1016/s0960-894x(01)00572-8
		9852253	10909	4	None	-5	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells	ChEMBL	631	9	0	4	7.9	N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C	10.1016/s0960-894x(01)00572-8
		CHEMBL129683	10909	4	None	-5	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells	ChEMBL	631	9	0	4	7.9	N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C	10.1016/s0960-894x(01)00572-8
		9830361	188405	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	538	7	1	4	7.1	C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		CHEMBL47739	188405	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	538	7	1	4	7.1	C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		9850582	204021	22	None	-1	6	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL56835	204021	22	None	-1	6	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44307741	210566	0	None	-15	2	Guinea pig	9.2	pKi	=	9.2	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL68234	210566	0	None	-15	2	Guinea pig	9.2	pKi	=	9.2	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL334721	218178	1	None	9	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL		None	None	None		CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1021/jm0010217
		10281234	99009	0	None	38	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	3	6	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL242631	99009	0	None	38	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	3	6	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		71458042	85671	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	692	8	5	6	2.0	O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		CHEMBL2112923	85671	0	None	1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	692	8	5	6	2.0	O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		44421493	91801	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	906	16	14	15	-3.6	O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL223994	91801	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	906	16	14	15	-3.6	O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		46237825	13463	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	650	13	2	5	6.3	Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2)cc1	10.1021/jm100176s
		CHEMBL1083559	13463	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	650	13	2	5	6.3	Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2)cc1	10.1021/jm100176s
		46238229	13540	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	13	2	7	5.0	COc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1	10.1021/jm100176s
		CHEMBL1083847	13540	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	13	2	7	5.0	COc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1	10.1021/jm100176s
		9874027	13544	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	12	2	6	5.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083851	13544	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	12	2	6	5.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237037	13557	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	631	12	2	6	6.1	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083864	13557	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	631	12	2	6	6.1	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237168	13560	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	609	11	2	6	6.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083867	13560	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	609	11	2	6	6.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46889663	13641	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	611	11	3	6	3.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(N)(=O)=O)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1084161	13641	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	611	11	3	6	3.6	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(N)(=O)=O)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237698	13643	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	624	12	2	6	4.7	CCS(=O)(=O)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1	10.1021/jm100176s
		CHEMBL1084163	13643	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	624	12	2	6	4.7	CCS(=O)(=O)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1	10.1021/jm100176s
		46238091	13782	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	600	12	2	6	5.0	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2o1	10.1021/jm100176s
		CHEMBL1084765	13782	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	600	12	2	6	5.0	O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2o1	10.1021/jm100176s
		2109	10909	4	None	-5	3	Human	9.2	pKi	=	9.2	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	631	9	0	4	7.9	N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C	10.1021/jm020094i
		9852253	10909	4	None	-5	3	Human	9.2	pKi	=	9.2	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	631	9	0	4	7.9	N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C	10.1021/jm020094i
		CHEMBL129683	10909	4	None	-5	3	Human	9.2	pKi	=	9.2	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	631	9	0	4	7.9	N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C	10.1021/jm020094i
		10281234	99009	0	None	38	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	562	11	3	6	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL242631	99009	0	None	38	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	562	11	3	6	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		9852630	211632	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	655	10	0	5	6.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL75598	211632	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	655	10	0	5	6.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		9896757	211760	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	732	12	0	6	7.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL76580	211760	0	None	-1	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	732	12	0	6	7.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		9831075	211932	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	657	10	1	6	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL78132	211932	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	657	10	1	6	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44380396	64494	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	3	7	6.4	CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL166921	64494	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	3	7	6.4	CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		9872857	188533	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	498	7	1	4	6.1	CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1	10.1021/jm000501v
		CHEMBL47775	188533	0	None	2	3	Human	9.2	pKi	=	9.2	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	498	7	1	4	6.1	CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1	10.1021/jm000501v
		44307773	109137	0	None	-17	2	Guinea pig	9.2	pKi	=	9.2	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	779	13	0	7	7.6	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL303803	109137	0	None	-17	2	Guinea pig	9.2	pKi	=	9.2	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	779	13	0	7	7.6	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		2089	9542	28	None	102	5	Human	9.2	pKi	=	9.2	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		3795	9542	28	None	102	5	Human	9.2	pKi	=	9.2	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		5311311	9542	28	None	102	5	Human	9.2	pKi	=	9.2	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		CHEMBL217406	9542	28	None	102	5	Human	9.2	pKi	=	9.2	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		10303894	92778	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	588	12	3	6	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)s1	10.1021/jm070289w
		CHEMBL230424	92778	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	588	12	3	6	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)s1	10.1021/jm070289w
		23626412	155932	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	659	11	3	7	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL394350	155932	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	659	11	3	7	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		10166998	173460	0	None	125	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	576	11	3	6	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL428203	173460	0	None	125	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	576	11	3	6	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44577893	176796	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	634	13	3	6	4.8	CCSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL444253	176796	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	634	13	3	6	4.8	CCSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		44577903	176824	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	630	13	3	6	4.1	COc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		CHEMBL444289	176824	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	630	13	3	6	4.1	COc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		11285716	148815	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	650	7	5	6	1.9	O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL387698	148815	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	650	7	5	6	1.9	O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL406287	148815	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	650	7	5	6	1.9	O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		46236796	13553	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	644	11	2	6	5.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083860	13553	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	644	11	2	6	5.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237169	13561	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	610	11	2	7	5.4	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ncccn5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083868	13561	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	610	11	2	7	5.4	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ncccn5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46889664	13644	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	672	11	2	6	5.1	CC/N=C(\N1CCOCC1)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1	10.1021/jm100176s
		CHEMBL1084164	13644	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	672	11	2	6	5.1	CC/N=C(\N1CCOCC1)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1	10.1021/jm100176s
		11285716	148815	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	650	7	5	6	1.9	O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL387698	148815	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	650	7	5	6	1.9	O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL406287	148815	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	650	7	5	6	1.9	O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		9810434	111160	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	713	12	1	6	6.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL310273	111160	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	713	12	1	6	6.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		101195489	162399	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	713	12	3	7	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		9875056	162399	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	713	12	3	7	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL404599	162399	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	713	12	3	7	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		9917970	211732	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	683	11	0	5	7.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL76437	211732	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	683	11	0	5	7.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44380206	64546	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	658	11	0	5	7.3	CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL166961	64546	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	658	11	0	5	7.3	CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44380448	127058	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	670	12	1	6	6.4	CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL352588	127058	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	670	12	1	6	6.4	CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		10370066	179557	1	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	540	7	1	5	5.9	C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		CHEMBL45129	179557	1	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	540	7	1	5	5.9	C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		44307821	108891	0	None	-4	2	Guinea pig	9.1	pKi	=	9.1	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL302329	108891	0	None	-4	2	Guinea pig	9.1	pKi	=	9.1	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		9874206	210550	0	None	-1	2	Guinea pig	9.1	pKi	=	9.1	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL68060	210550	0	None	-1	2	Guinea pig	9.1	pKi	=	9.1	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		23626108	85903	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	589	11	4	6	3.9	C[C@H]1CN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)C[C@@H](C)N1	10.1021/jm070289w
		CHEMBL2113292	85903	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	589	11	4	6	3.9	C[C@H]1CN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)C[C@@H](C)N1	10.1021/jm070289w
		54537190	86418	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	504	10	1	3	6.5	CCC(O)(CC)C1CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL2115073	86418	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	504	10	1	3	6.5	CCC(O)(CC)C1CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		23625325	150126	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	630	11	3	6	5.1	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL389744	150126	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	630	11	3	6	5.1	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		23626568	99005	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	673	12	3	7	3.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL242619	99005	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	673	12	3	7	3.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		9961936	109866	0	None	1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	723	12	1	8	5.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL307498	109866	0	None	1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	723	12	1	8	5.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		9961955	179552	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	726	11	0	7	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL451235	179552	0	None	-1	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	726	11	0	7	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44337354	12229	0	None	58	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	656	8	2	7	5.3	CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1	10.1016/s0960-894x(02)00645-5
		CHEMBL107469	12229	0	None	58	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	656	8	2	7	5.3	CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1	10.1016/s0960-894x(02)00645-5
		44307678	205454	0	None	-1	2	Guinea pig	9.1	pKi	=	9.1	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
		CHEMBL57993	205454	0	None	-1	2	Guinea pig	9.1	pKi	=	9.1	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
		44384522	66851	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	538	10	0	3	7.3	CCOC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/S0960-894X(00)80694-0
		CHEMBL173841	66851	0	None	-	1	Rat	9.1	pKi	=	9.1	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	538	10	0	3	7.3	CCOC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/S0960-894X(00)80694-0
		44351946	124147	1	None	1778	3	Human	9.0	pKi	=	9.0	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	568	8	0	3	7.3	CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm020094i
		CHEMBL339767	124147	1	None	1778	3	Human	9.0	pKi	=	9.0	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	568	8	0	3	7.3	CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm020094i
		18964186	211083	0	None	-3	3	Bovine	9.0	pKi	=	9	Binding	Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2	ChEMBL	510	8	1	3	6.2	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/j.bmcl.2004.06.053
		CHEMBL71397	211083	0	None	-3	3	Bovine	9.0	pKi	=	9	Binding	Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2	ChEMBL	510	8	1	3	6.2	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/j.bmcl.2004.06.053
		153996	119445	2	None	-3	3	Human	9.0	pKi	=	9	Binding	Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(01)00572-8
		CHEMBL330366	119445	2	None	-3	3	Human	9.0	pKi	=	9	Binding	Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(01)00572-8
		CHEMBL539021	119445	2	None	-3	3	Human	9.0	pKi	=	9	Binding	Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells	ChEMBL	639	10	1	6	5.7	COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(01)00572-8
		15508105	211610	0	None	1	3	Human	9.0	pKi	=	9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	675	10	1	7	7.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL75422	211610	0	None	1	3	Human	9.0	pKi	=	9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	675	10	1	7	7.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		10432325	24727	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	5	1	3	4.6	Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1	10.1021/jm00019a006
		CHEMBL126050	24727	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	5	1	3	4.6	Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1	10.1021/jm00019a006
		44281649	115797	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	625	11	1	7	6.0	CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32124	115797	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	625	11	1	7	6.0	CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281332	119687	0	None	100	2	Human	9.0	pKi	=	9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	588	11	1	8	6.4	CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33106	119687	0	None	100	2	Human	9.0	pKi	=	9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	588	11	1	8	6.4	CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		5769	10297	5	None	194	2	Human	9.0	pKi	=	9	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	512	6	1	4	6.5	O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C	10.1021/jm000501v
		9806459	10297	5	None	194	2	Human	9.0	pKi	=	9	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	512	6	1	4	6.5	O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C	10.1021/jm000501v
		CHEMBL295770	10297	5	None	194	2	Human	9.0	pKi	=	9	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	512	6	1	4	6.5	O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C	10.1021/jm000501v
		44434198	156602	0	None	25	2	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	623	11	3	6	4.0	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1	10.1016/j.bmcl.2007.06.053
		CHEMBL394878	156602	0	None	25	2	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	623	11	3	6	4.0	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1	10.1016/j.bmcl.2007.06.053
		44577908	177856	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	646	13	3	6	4.8	CSc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL445730	177856	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	646	13	3	6	4.8	CSc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		44577898	178081	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	12	3	5	4.3	O=C(/C=C/c1cccc(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL446086	178081	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	12	3	5	4.3	O=C(/C=C/c1cccc(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		44577906	179581	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	614	12	3	5	4.4	Cc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		CHEMBL451374	179581	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	614	12	3	5	4.4	Cc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		44577900	195664	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	634	12	3	5	4.8	O=C(/C=C/c1ccccc1Cl)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL507334	195664	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	634	12	3	5	4.8	O=C(/C=C/c1ccccc1Cl)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		11764212	91907	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	8	6	6	2.3	O=C1C[C@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL224888	91907	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	8	6	6	2.3	O=C1C[C@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		46237296	13545	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	12	2	6	5.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CN5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083852	13545	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	630	12	2	6	5.8	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CN5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46236392	13569	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	612	12	3	6	5.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5c[nH]cn5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083876	13569	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	612	12	3	6	5.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5c[nH]cn5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		9875181	178122	0	None	-7	2	Guinea pig	9.0	pKi	=	9	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL446146	178122	0	None	-7	2	Guinea pig	9.0	pKi	=	9	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	725	12	0	6	6.7	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		9810835	210354	0	None	-7	2	Guinea pig	9.0	pKi	=	9	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL66763	210354	0	None	-7	2	Guinea pig	9.0	pKi	=	9	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	767	12	0	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		9874206	210550	0	None	-1	2	Guinea pig	9.0	pKi	=	9	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL68060	210550	0	None	-1	2	Guinea pig	9.0	pKi	=	9	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		44385249	67978	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	516	8	1	4	6.3	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccsc1	10.1016/S0960-894X(00)80694-0
		CHEMBL176588	67978	0	None	-	1	Rat	9.0	pKi	=	9	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	516	8	1	4	6.3	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccsc1	10.1016/S0960-894X(00)80694-0
		18964186	211083	0	None	-3	3	Rat	9.0	pKi	=	9	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	510	8	1	3	6.2	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/S0960-894X(00)80694-0
		CHEMBL71397	211083	0	None	-3	3	Rat	9.0	pKi	=	9	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	510	8	1	3	6.2	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/S0960-894X(00)80694-0
		23626413	99007	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	589	10	3	6	3.0	CN1CCN(C(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1	10.1021/jm070289w
		CHEMBL242625	99007	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	589	10	3	6	3.0	CN1CCN(C(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1	10.1021/jm070289w
		44315298	109888	0	None	-1	3	Human	9.0	pKi	=	9.0	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	721	12	0	6	7.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL307733	109888	0	None	-1	3	Human	9.0	pKi	=	9.0	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	721	12	0	6	7.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44337208	12011	0	None	38	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	635	7	2	5	4.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL106300	12011	0	None	38	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	635	7	2	5	4.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44337207	14602	0	None	10	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	649	8	2	5	4.8	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL108955	14602	0	None	10	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	649	8	2	5	4.8	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		23626569	156243	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	659	11	3	7	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL394607	156243	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	659	11	3	7	3.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		9831674	111188	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	712	12	1	6	5.9	CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00462-6
		CHEMBL310334	111188	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	712	12	1	6	5.9	CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00462-6
		44315370	211618	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	789	14	0	7	7.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL75479	211618	0	None	-1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	789	14	0	7	7.9	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44315297	211646	0	None	1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	833	15	1	8	8.0	CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00462-6
		CHEMBL75698	211646	0	None	1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	833	15	1	8	8.0	CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00462-6
		44315299	211790	0	None	1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	737	12	0	6	8.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL76823	211790	0	None	1	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	737	12	0	6	8.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		10792233	183194	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	526	7	1	4	5.9	CC(C)C(=O)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1	10.1021/jm000501v
		CHEMBL45961	183194	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	526	7	1	4	5.9	CC(C)C(=O)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1	10.1021/jm000501v
		104974	10248	31	None	-3	7	Golden hamster	8.9	pKi	=	8.9	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		2111	10248	31	None	-3	7	Golden hamster	8.9	pKi	=	8.9	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		3481	10248	31	None	-3	7	Golden hamster	8.9	pKi	=	8.9	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		CHEMBL308148	10248	31	None	-3	7	Golden hamster	8.9	pKi	=	8.9	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		DB06660	10248	31	None	-3	7	Golden hamster	8.9	pKi	=	8.9	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		2089	9542	28	None	102	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL		None	None	None		None	10.1021/jm401823z
		3795	9542	28	None	102	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL		None	None	None		None	10.1021/jm401823z
		5311311	9542	28	None	102	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL		None	None	None		None	10.1021/jm401823z
		CHEMBL217406	9542	28	None	102	5	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL		None	None	None		None	10.1021/jm401823z
		9887650	23423	0	None	1	5	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	407	5	1	3	4.3	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		CHEMBL124208	23423	0	None	1	5	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	407	5	1	3	4.3	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		10476440	123780	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	406	5	2	2	3.9	O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		CHEMBL338825	123780	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	406	5	2	2	3.9	O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		10046881	125257	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	405	5	1	2	4.4	O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		CHEMBL341357	125257	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	405	5	1	2	4.4	O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		10121831	96214	0	None	158	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	618	17	3	5	6.5	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL237097	96214	0	None	158	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	618	17	3	5	6.5	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44434196	156003	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	594	11	3	5	4.8	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL394418	156003	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	594	11	3	5	4.8	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44434203	156006	0	None	158	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	594	11	3	5	4.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL394420	156006	0	None	158	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	594	11	3	5	4.5	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44577901	180239	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	634	12	3	5	4.8	O=C(/C=C/c1ccc(Cl)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL452960	180239	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	634	12	3	5	4.8	O=C(/C=C/c1ccc(Cl)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		44577902	195109	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	630	13	3	6	4.1	COc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL500797	195109	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	630	13	3	6	4.1	COc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		11480157	175486	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	906	16	14	15	-3.6	O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL436804	175486	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	906	16	14	15	-3.6	O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		46236649	13549	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	644	12	2	6	6.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083856	13549	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	644	12	2	6	6.3	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		44337355	12118	0	None	26	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	581	7	2	4	5.2	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL106877	12118	0	None	26	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	581	7	2	4	5.2	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44337174	14655	0	None	11	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	649	8	2	5	5.8	CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/s0960-894x(02)00645-5
		CHEMBL108997	14655	0	None	11	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	649	8	2	5	5.8	CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1	10.1016/s0960-894x(02)00645-5
		22861435	176276	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	489	9	1	4	6.2	CC/C(=N\O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL443264	176276	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	489	9	1	4	6.2	CC/C(=N\O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44302497	168507	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1095	24	8	14	2.9	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		CHEMBL413650	168507	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1095	24	8	14	2.9	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		118724118	123183	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1095	25	8	14	3.3	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		CHEMBL3360196	123183	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1095	25	8	14	3.3	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		23625476	103715	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	655	11	3	7	4.8	N#Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1	10.1021/jm070289w
		CHEMBL266108	103715	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	655	11	3	7	4.8	N#Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1	10.1021/jm070289w
		44380526	65102	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	665	11	0	6	6.9	CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL168272	65102	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	665	11	0	6	6.9	CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		18964216	66665	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	516	8	1	4	6.3	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1	10.1016/S0960-894X(00)80694-0
		CHEMBL173008	66665	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	516	8	1	4	6.3	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1	10.1016/S0960-894X(00)80694-0
		44302414	89225	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1110	25	8	14	3.3	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		CHEMBL217548	89225	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1110	25	8	14	3.3	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		190884	123184	8	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1110	26	8	14	3.7	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		CHEMBL3360197	123184	8	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1110	26	8	14	3.7	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		44302394	104026	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1124	26	8	14	3.7	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		CHEMBL268783	104026	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1124	26	8	14	3.7	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		118724119	123185	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1174	30	9	14	4.8	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		CHEMBL3360198	123185	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1174	30	9	14	4.8	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		44315369	109796	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	689	10	0	7	7.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL306952	109796	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	689	10	0	7	7.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44380091	127499	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	684	13	1	6	6.8	CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL354772	127499	0	None	-2	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	684	13	1	6	6.8	CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		10744541	108119	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	520	8	1	4	6.6	CC(C)[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		CHEMBL296857	108119	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	520	8	1	4	6.6	CC(C)[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		44385289	68141	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	560	8	1	3	7.4	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc2ccccc12	10.1016/S0960-894X(00)80694-0
		CHEMBL176853	68141	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	560	8	1	3	7.4	CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc2ccccc12	10.1016/S0960-894X(00)80694-0
		10232331	99946	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cc(Cl)ccc2s1	10.1021/jm070289w
		CHEMBL244364	99946	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cc(Cl)ccc2s1	10.1021/jm070289w
		10342250	23706	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	423	7	2	3	3.7	CC(=O)N(Cc1ccccc1)CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1021/jm00019a006
		CHEMBL125310	23706	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	423	7	2	3	3.7	CC(=O)N(Cc1ccccc1)CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1021/jm00019a006
		10477484	24045	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	425	5	1	3	4.5	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc(F)c1	10.1021/jm00019a006
		CHEMBL125696	24045	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	425	5	1	3	4.5	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc(F)c1	10.1021/jm00019a006
		10722305	117096	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	601	6	5	4	2.8	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1	10.1021/jm0010217
		CHEMBL323884	117096	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	601	6	5	4	2.8	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1	10.1021/jm0010217
		44434195	95369	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	652	17	3	5	6.6	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21	10.1016/j.bmcl.2007.06.053
		CHEMBL235574	95369	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	652	17	3	5	6.6	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21	10.1016/j.bmcl.2007.06.053
		44434202	158949	0	None	125	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	652	17	3	5	6.3	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1	10.1016/j.bmcl.2007.06.053
		CHEMBL396827	158949	0	None	125	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	652	17	3	5	6.3	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1	10.1016/j.bmcl.2007.06.053
		44577905	178430	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	614	12	3	5	4.4	Cc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL446604	178430	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	614	12	3	5	4.4	Cc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		44374556	59505	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	773	9	5	6	3.7	O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		CHEMBL159449	59505	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	773	9	5	6	3.7	O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		44374427	61567	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	765	12	6	8	0.9	O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		CHEMBL161242	61567	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	765	12	6	8	0.9	O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		11491576	91673	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	649	7	6	6	1.4	O=C1C[C@@H](N2CCNCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL223644	91673	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	649	7	6	6	1.4	O=C1C[C@@H](N2CCNCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		11343418	91847	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	720	9	6	7	0.9	CN1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL224427	91847	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	720	9	6	7	0.9	CN1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		44421491	144048	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	882	13	11	11	-1.5	CC(=O)N[C@H]1[C@H](NC(=O)CCC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O	10.1021/jm040832y
		CHEMBL375213	144048	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	882	13	11	11	-1.5	CC(=O)N[C@H]1[C@H](NC(=O)CCC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O	10.1021/jm040832y
		11479743	148816	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	648	7	5	5	3.0	O=C1C[C@@H](N2CCCCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL387699	148816	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	648	7	5	5	3.0	O=C1C[C@@H](N2CCCCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		10303737	92751	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	582	12	3	5	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)cc1	10.1021/jm070289w
		CHEMBL230324	92751	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	582	12	3	5	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)cc1	10.1021/jm070289w
		118724120	123186	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1181	29	9	15	3.2	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNCC(=O)Nc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		CHEMBL3360199	123186	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1181	29	9	15	3.2	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNCC(=O)Nc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O	10.1021/jm401823z
		10722305	117096	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	601	6	5	4	2.8	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1	10.1021/jm011127h
		CHEMBL323884	117096	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	601	6	5	4	2.8	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1	10.1021/jm011127h
		44343144	170799	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	662	9	7	8	0.8	O=C1C[C@H](NCc2nn[nH]n2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL420859	170799	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	662	9	7	8	0.8	O=C1C[C@H](NCc2nn[nH]n2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		9939307	210265	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL66106	210265	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		10840329	123743	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	546	8	1	4	7.2	CC[C@H](NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		CHEMBL33868	123743	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	546	8	1	4	7.2	CC[C@H](NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		44315390	211821	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	733	12	1	8	7.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL77042	211821	0	None	-1	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	733	12	1	8	7.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44380062	127542	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	740	14	2	6	6.7	CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL355295	127542	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	740	14	2	6	6.7	CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		9850582	204021	22	None	-1	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL56835	204021	22	None	-1	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44315576	212024	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	747	12	0	9	7.2	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL78851	212024	0	None	-1	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	747	12	0	9	7.2	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		23625179	90305	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	616	10	3	6	4.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL220365	90305	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	616	10	3	6	4.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		23625180	99350	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	644	12	3	6	5.3	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL243497	99350	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	644	12	3	6	5.3	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		9829402	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm0010217
		CHEMBL435324	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm0010217
		44331128	114034	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	814	12	6	9	1.4	CN(C)CCN(C)C(=O)c1nccnc1C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1016/s0960-894x(02)00539-5
		CHEMBL316943	114034	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	814	12	6	9	1.4	CN(C)CCN(C)C(=O)c1nccnc1C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1016/s0960-894x(02)00539-5
		9829402	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1016/s0960-894x(02)00539-5
		CHEMBL435324	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1016/s0960-894x(02)00539-5
		44434194	95332	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	575	11	3	6	3.4	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1	10.1016/j.bmcl.2007.06.053
		CHEMBL235353	95332	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	575	11	3	6	3.4	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1	10.1016/j.bmcl.2007.06.053
		44434197	156005	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	610	11	3	6	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL394419	156005	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	610	11	3	6	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44434204	160347	0	None	50	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	610	11	3	6	3.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL398028	160347	0	None	50	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	610	11	3	6	3.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44577899	179738	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	12	3	5	4.3	O=C(/C=C/c1ccc(F)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL451751	179738	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	12	3	5	4.3	O=C(/C=C/c1ccc(F)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		44577904	195480	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	630	13	3	6	4.1	COc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL504342	195480	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	630	13	3	6	4.1	COc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		9829402	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1016/s0960-894x(01)00841-1
		CHEMBL435324	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1016/s0960-894x(01)00841-1
		11332007	91856	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	785	14	11	10	-1.3	CC(=O)N[C@@H](CN[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O)[C@@H](O)[C@H](O)[C@H](O)CO	10.1021/jm040832y
		CHEMBL224532	91856	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	785	14	11	10	-1.3	CC(=O)N[C@@H](CN[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O)[C@@H](O)[C@H](O)[C@H](O)CO	10.1021/jm040832y
		11377052	144649	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	580	6	6	5	1.5	N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm040832y
		CHEMBL376141	144649	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	580	6	6	5	1.5	N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm040832y
		9829402	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm040832y
		CHEMBL435324	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm040832y
		46889639	13546	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	602	10	2	6	5.2	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083853	13546	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	602	10	2	6	5.2	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46237442	13550	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	575	12	3	5	5.9	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CCO)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083857	13550	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	575	12	3	5	5.9	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CCO)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		46236794	13552	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	602	10	2	6	5.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)CN4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083859	13552	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	602	10	2	6	5.0	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)CN4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1	10.1021/jm100176s
		46237575	13662	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	560	11	2	5	4.5	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C=O)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1084251	13662	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	560	11	2	5	4.5	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C=O)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		9829402	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm011127h
		CHEMBL435324	175279	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm011127h
		10026337	119612	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	441	5	1	3	5.0	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(Cl)cc1	10.1021/jm00019a006
		CHEMBL330826	119612	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	441	5	1	3	5.0	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(Cl)cc1	10.1021/jm00019a006
		10251624	125114	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	6	1	3	4.4	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1CCc1ccccc1	10.1021/jm00019a006
		CHEMBL341008	125114	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	6	1	3	4.4	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1CCc1ccccc1	10.1021/jm00019a006
		10069913	178088	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	406	5	2	3	3.6	O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)NN1Cc1ccccc1	10.1021/jm00019a006
		CHEMBL446099	178088	0	None	-	1	Rat	8.0	pKi	=	8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	406	5	2	3	3.6	O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)NN1Cc1ccccc1	10.1021/jm00019a006
		44281753	106593	0	None	9	2	Human	8.0	pKi	=	8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	626	11	1	5	7.8	CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL285476	106593	0	None	9	2	Human	8.0	pKi	=	8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	626	11	1	5	7.8	CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44353078	103368	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	595	7	5	5	2.6	COc1ccc(CC2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1	10.1021/jm0010217
		CHEMBL263194	103368	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	595	7	5	5	2.6	COc1ccc(CC2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1	10.1021/jm0010217
		10579116	123213	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	579	7	5	4	3.0	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCc2ccccc2)CN1	10.1021/jm0010217
		CHEMBL336053	123213	0	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	579	7	5	4	3.0	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCc2ccccc2)CN1	10.1021/jm0010217
		10232566	10990	0	None	-	1	Human	8.0	pKi	=	8	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	607	12	2	4	6.1	CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		CHEMBL100297	10990	0	None	-	1	Human	8.0	pKi	=	8	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	607	12	2	4	6.1	CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		44577894	179194	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	616	12	3	5	4.8	CC(C)c1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL447676	179194	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	616	12	3	5	4.8	CC(C)c1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		44577889	195034	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	632	14	3	6	4.5	CCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL499689	195034	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	632	14	3	6	4.5	CCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		71461644	85672	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	784	10	10	10	-0.9	O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O	10.1016/s0960-894x(01)00841-1
		CHEMBL2112924	85672	0	None	-1	2	Human	8.0	pKi	=	8	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	784	10	10	10	-0.9	O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O	10.1016/s0960-894x(01)00841-1
		49863731	22102	0	None	-5	3	Rat	8.0	pKi	=	8	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1266	18	10	12	6.1	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		CHEMBL1214024	22102	0	None	-5	3	Rat	8.0	pKi	=	8	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1266	18	10	12	6.1	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		44343084	17269	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	581	7	5	4	3.4	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC2=CC=CCC2)C(=O)N[C@H](CCc2ccccc2)CN1	10.1021/jm011127h
		CHEMBL116629	17269	0	None	-	1	Human	8.0	pKi	=	8	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	581	7	5	4	3.4	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC2=CC=CCC2)C(=O)N[C@H](CCc2ccccc2)CN1	10.1021/jm011127h
		23625471	150648	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	590	11	2	6	4.2	CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1	10.1021/jm070289w
		CHEMBL390174	150648	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	590	11	2	6	4.2	CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1	10.1021/jm070289w
		23625784	93038	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	605	11	4	5	4.2	O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(Cl)c(Cl)c2)CCCC1	10.1021/jm070289w
		CHEMBL231261	93038	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	605	11	4	5	4.2	O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(Cl)c(Cl)c2)CCCC1	10.1021/jm070289w
		10001491	124830	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	408	5	1	4	3.7	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccncc1	10.1021/jm00019a006
		CHEMBL340405	124830	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	408	5	1	4	3.7	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccncc1	10.1021/jm00019a006
		11743532	124889	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	432	5	1	4	4.2	N#Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1	10.1021/jm00019a006
		CHEMBL340747	124889	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	432	5	1	4	4.2	N#Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1	10.1021/jm00019a006
		10407490	175332	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	381	7	3	3	3.5	OC1(CNCc2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1021/jm00019a006
		CHEMBL435619	175332	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	381	7	3	3	3.5	OC1(CNCc2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1021/jm00019a006
		44391105	72402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	516	12	3	5	3.8	O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL183414	72402	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	516	12	3	5	3.8	O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44281391	106756	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	688	11	1	5	9.2	CO/N=C(\CO/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL286589	106756	0	None	-	1	Human	7.0	pKi	=	7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	688	11	1	5	9.2	CO/N=C(\CO/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44434175	95952	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	540	15	4	7	2.2	CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCOCCOCCN	10.1016/j.bmcl.2007.06.053
		CHEMBL236659	95952	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	540	15	4	7	2.2	CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCOCCOCCN	10.1016/j.bmcl.2007.06.053
		44434178	96085	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	13	3	5	4.9	CCN(CC)CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL236873	96085	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	13	3	5	4.9	CCN(CC)CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44434182	96209	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	548	12	3	5	4.5	CCN(CC)CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL237081	96209	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	548	12	3	5	4.5	CCN(CC)CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44434192	96210	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	589	11	3	6	3.8	CN1CCN(CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1	10.1016/j.bmcl.2007.06.053
		CHEMBL237082	96210	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	589	11	3	6	3.8	CN1CCN(CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1	10.1016/j.bmcl.2007.06.053
		44434187	96380	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	10	3	6	3.5	O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL237516	96380	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	10	3	6	3.5	O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44434197	156005	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	610	11	3	6	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL394419	156005	0	None	1	2	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	610	11	3	6	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44434179	173832	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	14	4	5	5.1	NCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL428906	173832	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	14	4	5	5.1	NCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44301551	108584	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	342	8	3	3	3.2	Cc1ccccc1OCC(O)CNCCc1c[nH]c2ccc(F)cc12	10.1016/S0960-894X(01)80541-2
		CHEMBL300174	108584	0	None	-	1	Rat	6.0	pKi	=	6	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	342	8	3	3	3.2	Cc1ccccc1OCC(O)CNCCc1c[nH]c2ccc(F)cc12	10.1016/S0960-894X(01)80541-2
		44391061	71631	0	None	-	1	Human	6.0	pKi	=	6	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL182104	71631	0	None	-	1	Human	6.0	pKi	=	6	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		23625323	99138	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	522	11	2	6	2.5	CN(CC(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(=O)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL243069	99138	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	522	11	2	6	2.5	CN(CC(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(=O)c1cc2ccccc2s1	10.1021/jm070289w
		44391019	70654	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL180396	70654	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		51351496	67382	7	None	-18	4	Human	5.0	pKi	=	5	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	410	4	0	5	3.7	COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1	10.1016/j.bmcl.2011.02.033
		CHEMBL1760205	67382	7	None	-18	4	Human	5.0	pKi	=	5	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	410	4	0	5	3.7	COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1	10.1016/j.bmcl.2011.02.033
		90417914	125643	0	None	-3235	5	Human	5.0	pKi	=	5	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	433	4	0	7	5.0	CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1	10.1021/jm5017413
		CHEMBL3422015	125643	0	None	-3235	5	Human	5.0	pKi	=	5	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	433	4	0	7	5.0	CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1	10.1021/jm5017413
		44434159	152575	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	4	5	4.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O	10.1016/j.bmcl.2007.06.053
		CHEMBL391696	152575	0	None	-	1	Human	5.0	pKi	=	5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	4	5	4.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O	10.1016/j.bmcl.2007.06.053
		44392497	71783	0	None	-	1	Human	5.0	pKi	=	5	Binding	Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor	ChEMBL	535	7	0	3	6.1	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1	10.1016/j.bmcl.2005.05.134
		CHEMBL182317	71783	0	None	-	1	Human	5.0	pKi	=	5	Binding	Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor	ChEMBL	535	7	0	3	6.1	O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1	10.1016/j.bmcl.2005.05.134
		57391133	75142	0	None	-1	2	Human	4.0	pKi	=	4	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHO cells	ChEMBL	691	12	3	7	4.4	COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1	10.1016/j.ejmech.2011.08.042
		CHEMBL1916635	75142	0	None	-1	2	Human	4.0	pKi	=	4	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHO cells	ChEMBL	691	12	3	7	4.4	COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1	10.1016/j.ejmech.2011.08.042
		2098	10466	36	None	-457	6	Human	7.0	pKi	=	7.0	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		36511	10466	36	None	-457	6	Human	7.0	pKi	=	7.0	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		3805	10466	36	None	-457	6	Human	7.0	pKi	=	7.0	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		3835	10466	36	None	-457	6	Human	7.0	pKi	=	7.0	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		CHEMBL235363	10466	36	None	-457	6	Human	7.0	pKi	=	7.0	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		10232846	120893	0	None	-11	2	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
		CHEMBL332793	120893	0	None	-11	2	Human	7.0	pKi	=	7.0	Binding	In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
		CHEMBL411905	219741	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)/N=C(/S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)C(N)=O	10.1021/jm00039a012
		44380763	126811	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	690	12	1	5	9.1	CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL350360	126811	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	690	12	1	5	9.1	CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		5353853	24758	47	None	-14	15	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	24758	47	None	-14	15	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	24758	47	None	-14	15	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		25221995	203630	0	None	-40	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	601	8	0	3	6.5	CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm900948q
		CHEMBL565894	203630	0	None	-40	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	601	8	0	3	6.5	CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm900948q
		10010096	106666	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	719	10	1	6	8.6	CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL285986	106666	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	719	10	1	6	8.6	CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44215303	125740	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	710	12	1	6	7.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL342341	125740	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	710	12	1	6	7.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44363952	127789	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	696	12	1	6	7.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL356508	127789	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	696	12	1	6	7.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44380069	64391	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	714	14	0	6	8.1	CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL166842	64391	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	714	14	0	6	8.1	CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44266459	11293	0	None	-91	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	381	5	2	3	5.4	CC[C@@H](NC(=O)c1c(N)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		CHEMBL10224	11293	0	None	-91	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	381	5	2	3	5.4	CC[C@@H](NC(=O)c1c(N)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		44281392	106734	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	690	12	1	5	8.8	CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL286433	106734	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	690	12	1	5	8.8	CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281722	118168	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	590	11	1	5	7.8	CO/N=C(\COCc1ccc2ccccc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32717	118168	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	590	11	1	5	7.8	CO/N=C(\COCc1ccc2ccccc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44215305	126032	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	695	12	0	5	8.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL343627	126032	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	695	12	0	5	8.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		10002284	23653	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	5	1	3	4.6	Cc1ccccc1CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O	10.1021/jm00019a006
		CHEMBL125001	23653	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	5	1	3	4.6	Cc1ccccc1CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O	10.1021/jm00019a006
		44434168	95528	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	580	15	4	7	3.2	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL236250	95528	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	580	15	4	7	3.2	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		90663622	113486	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	614	15	4	7	3.3	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21	10.1016/j.bmcl.2007.06.053
		CHEMBL3143848	113486	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	614	15	4	7	3.3	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21	10.1016/j.bmcl.2007.06.053
		44577891	195455	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	646	15	3	6	4.9	CCCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL503837	195455	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	646	15	3	6	4.9	CCCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		23625633	99355	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	599	11	4	5	3.4	O=C(Nc1ccc(Br)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		CHEMBL243502	99355	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	599	11	4	5	3.4	O=C(Nc1ccc(Br)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		44342868	17333	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	680	10	7	6	1.5	O=C(O)CCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm011127h
		CHEMBL116969	17333	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	680	10	7	6	1.5	O=C(O)CCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm011127h
		44342903	117085	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	597	7	5	5	3.0	COc1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC3=CC=CCC3)C(=O)N2)cc1	10.1021/jm011127h
		CHEMBL323836	117085	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	597	7	5	5	3.0	COc1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC3=CC=CCC3)C(=O)N2)cc1	10.1021/jm011127h
		CHEMBL431641	220405	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm9807151
		44390541	70813	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	558	11	3	5	5.3	CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		CHEMBL180725	70813	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	558	11	3	5	5.3	CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		44391089	71050	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	516	12	3	5	3.8	O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL180942	71050	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	516	12	3	5	3.8	O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL5092328	222138	5	None	6	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis	ChEMBL		None	None	None		CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N	10.1021/acs.jmedchem.1c00935
		8867347	67377	5	None	-10	4	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	362	4	1	4	3.0	COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1	10.1016/j.bmcl.2011.02.033
		CHEMBL1760200	67377	5	None	-10	4	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	362	4	1	4	3.0	COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1	10.1016/j.bmcl.2011.02.033
		44305793	107622	0	None	-5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	662	10	2	5	8.5	O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		CHEMBL293432	107622	0	None	-5	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	662	10	2	5	8.5	O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		6604014	214627	7	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm9602423
		CHEMBL9643	214627	7	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm9602423
		5764	10270	46	None	-58	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1	10.1021/jm960818o
		6604858	10270	46	None	-58	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1	10.1021/jm960818o
		CHEMBL9843	10270	46	None	-58	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1	10.1021/jm960818o
		1016	10519	78	None	-16	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	10519	78	None	-16	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	10519	78	None	-16	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	10519	78	None	-16	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	10519	78	None	-16	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	10519	78	None	-16	35	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		23625473	173554	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	540	11	3	5	2.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cccc(Cl)c1	10.1021/jm070289w
		CHEMBL428394	173554	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	540	11	3	5	2.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cccc(Cl)c1	10.1021/jm070289w
		19610193	114009	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	654	10	1	7	5.3	COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(02)00645-5
		CHEMBL316740	114009	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	654	10	1	7	5.3	COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC	10.1016/s0960-894x(02)00645-5
		10454808	175329	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	420	5	2	3	3.4	O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)C(=O)N1Cc1ccccc1	10.1021/jm00019a006
		CHEMBL435610	175329	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	420	5	2	3	3.4	O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)C(=O)N1Cc1ccccc1	10.1021/jm00019a006
		44331223	215170	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	706	16	2	8	4.3	O=C(c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		CHEMBL99608	215170	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	706	16	2	8	4.3	O=C(c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		44434169	95818	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	568	10	4	5	4.8	NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)cc1	10.1016/j.bmcl.2007.06.053
		CHEMBL236458	95818	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	568	10	4	5	4.8	NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)cc1	10.1016/j.bmcl.2007.06.053
		44434181	96088	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	576	15	4	5	5.5	NCCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL236874	96088	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	576	15	4	5	5.5	NCCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		10995343	27618	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccccc2)CN1	10.1021/jm0010217
		CHEMBL131024	27618	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccccc2)CN1	10.1021/jm0010217
		10554969	85275	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC[C@H](Cc2ccccc2)N1	10.1021/jm0010217
		CHEMBL2111858	85275	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC[C@H](Cc2ccccc2)N1	10.1021/jm0010217
		11801084	85558	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@H](Cc2ccccc2)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm0010217
		CHEMBL2112669	85558	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.6	O=C1CCC(=O)N[C@H](Cc2ccccc2)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm0010217
		10576528	117262	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	475	4	5	4	0.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1	10.1021/jm0010217
		CHEMBL324804	117262	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	475	4	5	4	0.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1	10.1021/jm0010217
		10576528	117262	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	475	4	5	4	0.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1	10.1021/jm011127h
		CHEMBL324804	117262	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	475	4	5	4	0.9	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1	10.1021/jm011127h
		71533722	125638	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	421	3	0	7	4.7	Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1	10.1021/jm5017413
		CHEMBL3422010	125638	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	421	3	0	7	4.7	Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1	10.1021/jm5017413
		71549769	125646	0	None	-3981	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	422	3	0	8	4.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1	10.1021/jm5017413
		CHEMBL3422018	125646	0	None	-3981	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	422	3	0	8	4.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1	10.1021/jm5017413
		44312761	110354	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	576	12	0	8	6.0	CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1	10.1016/s0960-894x(02)00471-7
		CHEMBL308613	110354	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	576	12	0	8	6.0	CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1	10.1016/s0960-894x(02)00471-7
		44312564	211341	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	486	9	1	8	3.8	CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2S1	10.1016/s0960-894x(02)00471-7
		CHEMBL72979	211341	0	None	-	1	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	486	9	1	8	3.8	CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2S1	10.1016/s0960-894x(02)00471-7
		1836	9370	59	None	-40	15	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		3340	9370	59	None	-40	15	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		5281040	9370	59	None	-40	15	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		CHEMBL787	9370	59	None	-40	15	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		DB00471	9370	59	None	-40	15	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	nan
		44314834	211928	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	667	11	0	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL78092	211928	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	667	11	0	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44281359	117346	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	546	11	1	5	7.1	CO/N=C(\COCC1CCCCC1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32533	117346	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	546	11	1	5	7.1	CO/N=C(\COCC1CCCCC1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		9987474	211612	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	13	1	7	6.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL75436	211612	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	13	1	7	6.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		22405758	203845	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	476	9	1	3	5.7	CCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL56739	203845	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	476	9	1	3	5.7	CCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44390601	71049	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	536	11	3	5	4.5	O=C(Nc1ccc(Sc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL180940	71049	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	536	11	3	5	4.5	O=C(Nc1ccc(Sc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44281785	118140	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	652	11	1	5	9.3	CO/N=C(\COCc1cc(C(C)(C)C)cc(C(C)(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32700	118140	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	652	11	1	5	9.3	CO/N=C(\COCc1cc(C(C)(C)C)cc(C(C)(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44282004	128539	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	675	11	2	5	8.3	CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL35891	128539	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	675	11	2	5	8.3	CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		51351504	67383	1	None	-34	4	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	410	4	0	5	3.7	COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1	10.1016/j.bmcl.2011.02.033
		CHEMBL1760206	67383	1	None	-34	4	Human	4.9	pKi	=	4.9	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	410	4	0	5	3.7	COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1	10.1016/j.bmcl.2011.02.033
		2351	10059	64	None	-13	21	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	10059	64	None	-13	21	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	10059	64	None	-13	21	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	10059	64	None	-13	21	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	10059	64	None	-13	21	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		132837	9018	55	None	-18	5	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1021/jm100157m
		9461	9018	55	None	-18	5	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1021/jm100157m
		CHEMBL22870	9018	55	None	-18	5	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	472	6	2	3	5.0	CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2	10.1021/jm100157m
		133	9274	52	None	-165	43	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	9274	52	None	-165	43	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	9274	52	None	-165	43	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	9274	52	None	-165	43	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	9274	52	None	-165	43	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		44281397	169747	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	554	11	1	5	7.0	CO/N=C(\COCc1ccccc1C)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL417490	169747	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	554	11	1	5	7.0	CO/N=C(\COCc1ccccc1C)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44364001	46678	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	717	13	1	5	8.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL147767	46678	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	717	13	1	5	8.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		3598	194600	76	None	-1	7	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		CHEMBL496	194600	76	None	-1	7	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	nan
		1024	8072	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		162639143	8072	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		5284373	8072	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		760	8072	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		CHEMBL160	8072	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		DB00091	8072	71	None	-	1	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		44380732	65766	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	706	13	2	6	8.1	OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL169002	65766	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	706	13	2	6	8.1	OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44337371	12063	0	None	-4	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	720	7	1	4	6.8	O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		CHEMBL106572	12063	0	None	-4	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	720	7	1	4	6.8	O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		44337288	14817	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	632	7	1	4	6.6	O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		CHEMBL109092	14817	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	632	7	1	4	6.6	O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		44281345	117257	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	554	11	1	5	7.0	CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32477	117257	0	None	10	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	554	11	1	5	7.0	CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44215306	43948	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	725	14	1	6	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL145302	43948	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	725	14	1	6	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		23625475	99338	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	632	11	3	5	2.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(I)cc1	10.1021/jm070289w
		CHEMBL243280	99338	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	632	11	3	5	2.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(I)cc1	10.1021/jm070289w
		155565189	182344	0	None	2	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
		CHEMBL4579120	182344	0	None	2	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method	ChEMBL	634	7	0	9	6.2	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12	10.1016/j.ejmech.2019.04.064
		71533722	125638	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	421	3	0	7	4.7	Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1	nan
		CHEMBL3422010	125638	0	None	-933	5	Human	4.9	pKi	=	4.9	Binding	Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	421	3	0	7	4.7	Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1	nan
		44300668	204604	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	448	8	1	3	4.9	CN(CC(CCN1CCC(CO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(98)00037-7
		CHEMBL57224	204604	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	448	8	1	3	4.9	CN(CC(CCN1CCC(CO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(98)00037-7
		CHEMBL102128	215233	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm9807151
		2132	10516	58	None	-97	6	Human	6.8	pKi	=	6.8	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		5311424	10516	58	None	-97	6	Human	6.8	pKi	=	6.8	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		CHEMBL10188	10516	58	None	-97	6	Human	6.8	pKi	=	6.8	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		44363756	46611	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	703	12	1	5	8.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL147715	46611	0	None	-8	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	703	12	1	5	8.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		10691318	174392	4	None	-102	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	382	5	2	3	5.5	CC[C@@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		CHEMBL430118	174392	4	None	-102	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	382	5	2	3	5.5	CC[C@@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		2132	10516	58	None	-97	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm000501v
		5311424	10516	58	None	-97	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm000501v
		CHEMBL10188	10516	58	None	-97	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm000501v
		44363877	45924	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	709	12	1	5	8.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL146947	45924	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	709	12	1	5	8.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44281538	117090	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	696	11	1	5	8.2	CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32385	117090	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	696	11	1	5	8.2	CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44363442	44714	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	697	12	1	6	8.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL145959	44714	0	None	-1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	697	12	1	6	8.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44329517	215056	0	None	36	2	Golden hamster	7.8	pKi	=	7.8	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	387	4	1	6	3.1	CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O	10.1016/0960-894X(95)00502-K
		CHEMBL98929	215056	0	None	36	2	Golden hamster	7.8	pKi	=	7.8	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	387	4	1	6	3.1	CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O	10.1016/0960-894X(95)00502-K
		10001490	168722	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	408	5	1	4	3.7	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccn1	10.1021/jm00019a006
		CHEMBL415518	168722	0	None	-	1	Rat	7.8	pKi	=	7.8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	408	5	1	4	3.7	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccn1	10.1021/jm00019a006
		44577910	194990	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	606	12	3	6	4.2	O=C(/C=C/c1cccs1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL499153	194990	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	606	12	3	6	4.2	O=C(/C=C/c1cccs1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		2090	9543	25	None	-38	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis	ChEMBL		None	None	None		None	10.1021/jm5017413
		5311312	9543	25	None	-38	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis	ChEMBL		None	None	None		None	10.1021/jm5017413
		CHEMBL437797	9543	25	None	-38	4	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis	ChEMBL		None	None	None		None	10.1021/jm5017413
		11421866	143992	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	580	6	6	5	1.5	N[C@@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm040832y
		CHEMBL375053	143992	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	580	6	6	5	1.5	N[C@@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm040832y
		46236800	13555	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	616	11	2	6	5.4	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		CHEMBL1083862	13555	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor	ChEMBL	616	11	2	6	5.4	Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1	10.1021/jm100176s
		1752	52535	59	None	-1	5	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		CHEMBL153062	52535	59	None	-1	5	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	220	8	1	1	4.7	CCCCCCCCCc1ccc(O)cc1	nan
		1548953	214458	27	None	-7	17	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL954	214458	27	None	-7	17	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1	nan
		CHEMBL1201469	21279	0	None	1	4	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL		None	None	None		None	nan
		2406	107180	89	None	-16	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL290106	107180	89	None	-16	12	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	nan
		CHEMBL103939	215239	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm9807151
		44281743	106415	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	690	11	1	5	9.1	CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL284244	106415	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	690	11	1	5	9.1	CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		10471895	124855	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	331	3	1	3	2.8	CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O	10.1021/jm00019a006
		CHEMBL340548	124855	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	331	3	1	3	2.8	CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O	10.1021/jm00019a006
		44301858	206866	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	372	5	2	3	3.5	N#Cc1ccc2[nH]cc(CCN3CCC(NC(=O)c4ccccc4)CC3)c2c1	10.1016/S0960-894X(01)80541-2
		CHEMBL59594	206866	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	372	5	2	3	3.5	N#Cc1ccc2[nH]cc(CCN3CCC(NC(=O)c4ccccc4)CC3)c2c1	10.1016/S0960-894X(01)80541-2
		CHEMBL583102	222560	6	None	-5248	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human NK2 receptorBinding affinity at human NK2 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1021/jm2017072
		CHEMBL583102	222560	6	None	-5248	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL		None	None	None		CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1021/jm900948q
		11203189	71062	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	520	11	3	5	4.2	O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL181004	71062	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	520	11	3	5	4.2	O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44337353	12199	0	None	9	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	635	7	2	5	4.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL107306	12199	0	None	9	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	635	7	2	5	4.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44363983	24938	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	769	15	2	7	7.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL126970	24938	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	769	15	2	7	7.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44363926	45843	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	669	11	1	6	7.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL146882	45843	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	669	11	1	6	7.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		10010039	46679	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	711	14	2	6	8.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL147769	46679	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	711	14	2	6	8.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44380457	64890	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	0	7	6.6	COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL167613	64890	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	0	7	6.6	COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		49863733	22104	0	None	-2	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1477	21	11	14	6.8	CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm100157m
		CHEMBL1214026	22104	0	None	-2	4	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1477	21	11	14	6.8	CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm100157m
		44391130	71709	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	492	10	2	4	3.1	O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1	10.1016/j.bmcl.2004.11.045
		CHEMBL182264	71709	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	492	10	2	4	3.1	O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1	10.1016/j.bmcl.2004.11.045
		44391136	72878	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	487	11	2	5	3.1	CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL183917	72878	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	487	11	2	5	3.1	CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		73354570	96185	0	None	-13	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	814	8	8	9	0.4	COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C	10.1021/jm00029a007
		CHEMBL2370513	96185	0	None	-13	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	814	8	8	9	0.4	COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C	10.1021/jm00029a007
		155558726	181587	0	None	-3	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
		CHEMBL4562303	181587	0	None	-3	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method	ChEMBL	835	11	0	13	6.7	CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C	10.1016/j.ejmech.2019.04.064
		4189	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	213701	96	None	-18	34	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		5318	22348	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1200348	22348	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1221	22348	49	None	-1	13	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		44281957	106592	0	None	-27	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	703	10	1	5	8.1	CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL285475	106592	0	None	-27	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	703	10	1	5	8.1	CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44380290	106866	0	None	-21	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	736	14	0	9	6.5	CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL287369	106866	0	None	-21	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	736	14	0	9	6.5	CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		15887537	115823	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	700	7	1	4	7.3	O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		CHEMBL321270	115823	0	None	-3	3	Human	7.8	pKi	=	7.8	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	700	7	1	4	7.3	O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		44281303	107246	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	582	11	1	8	6.2	CO/N=C(\COCc1ccc2nonc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL290786	107246	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	582	11	1	8	6.2	CO/N=C(\COCc1ccc2nonc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44314946	211842	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	14	0	6	8.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL77235	211842	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	14	0	6	8.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		5362440	16793	63	None	-	1	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	613	11	4	7	2.9	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O	nan
		CHEMBL115	16793	63	None	-	1	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	613	11	4	7	2.9	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O	nan
		44266422	11214	0	None	-79	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	423	7	1	3	5.8	CC[C@@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		CHEMBL10162	11214	0	None	-79	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	423	7	1	3	5.8	CC[C@@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		10812218	178851	0	None	-79	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	423	7	1	3	5.8	CC[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		CHEMBL44722	178851	0	None	-79	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	423	7	1	3	5.8	CC[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		44337414	15987	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	889	13	2	7	9.1	O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL110507	15987	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	889	13	2	7	9.1	O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00645-5
		44329163	118226	0	None	-2	2	Human	4.8	pKi	=	4.8	Binding	Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor	ChEMBL	344	3	2	6	2.8	Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL327531	118226	0	None	-2	2	Human	4.8	pKi	=	4.8	Binding	Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor	ChEMBL	344	3	2	6	2.8	Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		22901328	214447	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	420	4	3	6	4.2	CC(C)c1nc2[nH]c(N3CCC(O)CC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL95347	214447	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	420	4	3	6	4.2	CC(C)c1nc2[nH]c(N3CCC(O)CC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44281713	106439	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	600	13	1	7	6.7	CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL284396	106439	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	600	13	1	7	6.7	CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		9849950	108147	0	None	64	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	458	8	1	4	5.3	CCC(CC)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12	10.1021/jm000501v
		CHEMBL297086	108147	0	None	64	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	458	8	1	4	5.3	CCC(CC)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12	10.1021/jm000501v
		10189341	16891	0	None	-10	2	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
		CHEMBL115633	16891	0	None	-10	2	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
		141952732	127243	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	13	3	7	7.8	N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O	10.1016/s0960-894x(02)00027-6
		44380527	127243	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	13	3	7	7.8	N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O	10.1016/s0960-894x(02)00027-6
		CHEMBL354091	127243	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	13	3	7	7.8	N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O	10.1016/s0960-894x(02)00027-6
		44380095	127634	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	687	11	1	6	8.6	N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL355868	127634	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	687	11	1	6	8.6	N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		10390570	23316	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	483	6	1	3	5.9	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(c1ccccc1)c1ccccc1	10.1021/jm00019a006
		CHEMBL123731	23316	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	483	6	1	3	5.9	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(c1ccccc1)c1ccccc1	10.1021/jm00019a006
		10093650	23575	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	5	1	3	4.9	CC(c1ccccc1)N1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O	10.1021/jm00019a006
		CHEMBL124624	23575	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	5	1	3	4.9	CC(c1ccccc1)N1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O	10.1021/jm00019a006
		10344101	123619	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	457	5	1	3	5.5	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc2ccccc2c1	10.1021/jm00019a006
		CHEMBL338030	123619	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	457	5	1	3	5.5	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc2ccccc2c1	10.1021/jm00019a006
		11802167	85563	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	633	6	5	4	3.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)CN1	10.1021/jm0010217
		CHEMBL2112675	85563	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	633	6	5	4	3.6	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)CN1	10.1021/jm0010217
		44434171	96101	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	614	15	4	7	3.0	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1	10.1016/j.bmcl.2007.06.053
		CHEMBL236890	96101	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	614	15	4	7	3.0	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1	10.1016/j.bmcl.2007.06.053
		44434184	96287	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	560	11	3	5	4.7	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL237303	96287	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	560	11	3	5	4.7	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44577885	195398	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	13	3	6	4.1	CCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		CHEMBL502914	195398	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	13	3	6	4.1	CCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		54583959	67443	0	None	-38	4	Human	4.7	pKi	=	4.7	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	410	5	1	4	3.7	COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1	10.1016/j.bmcl.2011.02.033
		CHEMBL1760339	67443	0	None	-38	4	Human	4.7	pKi	=	4.7	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	410	5	1	4	3.7	COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1	10.1016/j.bmcl.2011.02.033
		11790	106263	98	None	-2	4	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	272	1	0	2	4.6	O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12	nan
		CHEMBL283196	106263	98	None	-2	4	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	272	1	0	2	4.6	O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12	nan
		118724123	123190	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	954	29	11	16	-1.6	CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O	10.1021/jm401823z
		CHEMBL3360202	123190	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	954	29	11	16	-1.6	CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O	10.1021/jm401823z
		44363948	43151	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	653	11	0	5	8.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL144668	43151	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	653	11	0	5	8.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44380795	212911	0	None	-7	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	13	1	7	8.3	COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL85980	212911	0	None	-7	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	13	1	7	8.3	COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		10454135	24744	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	408	5	1	4	3.7	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccnc1	10.1021/jm00019a006
		CHEMBL126158	24744	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	408	5	1	4	3.7	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccnc1	10.1021/jm00019a006
		44380415	127093	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	683	12	1	6	5.9	CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL352813	127093	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	683	12	1	6	5.9	CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44281685	106807	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	587	10	1	6	6.6	CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL286901	106807	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	587	10	1	6	6.6	CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281977	116171	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	595	10	1	5	6.8	CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32197	116171	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	595	10	1	5	6.8	CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281976	117351	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	627	12	1	7	6.2	CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32537	117351	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	627	12	1	7	6.2	CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		10394882	120589	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	689	10	2	5	7.9	CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33249	120589	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	689	10	2	5	7.9	CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		137633652	163375	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	749	24	10	10	-1.5	CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/acs.jmedchem.6b01422
		CHEMBL4068783	163375	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	749	24	10	10	-1.5	CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O	10.1021/acs.jmedchem.6b01422
		9918520	109528	0	None	-2	2	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL305055	109528	0	None	-2	2	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	753	12	1	7	5.8	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		9896563	110557	0	None	-5	2	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
		CHEMBL308891	110557	0	None	-5	2	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	711	12	1	6	6.4	CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(02)00340-2
		44307953	175973	0	None	-35	2	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	784	12	1	7	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL440679	175973	0	None	-35	2	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	784	12	1	7	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL540651	175973	0	None	-35	2	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	784	12	1	7	6.4	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		9939307	210265	0	None	-6	4	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL66106	210265	0	None	-6	4	Guinea pig	8.7	pKi	=	8.7	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	640	10	0	5	7.0	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		52918297	65263	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	611	12	2	6	4.8	O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2cn1	10.1016/j.bmcl.2011.01.074
		CHEMBL1683152	65263	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	611	12	2	6	4.8	O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2cn1	10.1016/j.bmcl.2011.01.074
		23626111	92921	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	645	12	3	7	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL231173	92921	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	645	12	3	7	4.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		22405735	85195	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	489	9	1	4	6.2	CC/C(=N/O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL2111522	85195	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	489	9	1	4	6.2	CC/C(=N/O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		23625785	159449	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	556	11	3	5	3.4	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ccccc2c1	10.1021/jm070289w
		CHEMBL397264	159449	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	556	11	3	5	3.4	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ccccc2c1	10.1021/jm070289w
		10187380	159448	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	545	11	4	5	2.8	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2[nH]1	10.1021/jm070289w
		CHEMBL397263	159448	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	545	11	4	5	2.8	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2[nH]1	10.1021/jm070289w
		10209751	92780	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	559	11	3	6	2.8	Cn1c(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc2ccccc21	10.1021/jm070289w
		CHEMBL230426	92780	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	559	11	3	6	2.8	Cn1c(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc2ccccc21	10.1021/jm070289w
		23653789	10359	24	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	555	5	0	3	7.7	O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F	10.1021/jm8016514
		9280	10359	24	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	555	5	0	3	7.7	O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F	10.1021/jm8016514
		CHEMBL447955	10359	24	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	555	5	0	3	7.7	O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F	10.1021/jm8016514
		DB12973	10359	24	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	555	5	0	3	7.7	O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F	10.1021/jm8016514
		9825316	186287	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	456	6	2	4	5.0	C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		CHEMBL47412	186287	0	None	1	3	Human	8.6	pKi	=	8.6	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	456	6	2	4	5.0	C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		44315267	112282	0	None	40	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	701	11	1	7	8.5	CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL312141	112282	0	None	40	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	701	11	1	7	8.5	CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44315209	211690	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	728	12	0	8	7.9	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL76093	211690	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	728	12	0	8	7.9	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		9979586	23581	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	4	1	4	4.0	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(=O)c1ccccc1	10.1021/jm00019a006
		CHEMBL124648	23581	0	None	-	1	Rat	8.6	pKi	=	8.6	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	421	4	1	4	4.0	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(=O)c1ccccc1	10.1021/jm00019a006
		44353064	164136	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	960	12	13	13	-3.9	CC(=O)N[C@@H]1[C@@H](CO)[C@H](O)[C@@H](CO)O[C@H]1NC(=O)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1021/jm0010217
		CHEMBL407782	164136	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	960	12	13	13	-3.9	CC(=O)N[C@@H]1[C@@H](CO)[C@H](O)[C@@H](CO)O[C@H]1NC(=O)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2	10.1021/jm0010217
		44434205	96177	0	None	50	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	623	11	3	6	3.7	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1	10.1016/j.bmcl.2007.06.053
		CHEMBL237048	96177	0	None	50	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	623	11	3	6	3.7	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1	10.1016/j.bmcl.2007.06.053
		44374598	126269	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	811	10	10	10	-1.2	CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
		CHEMBL345402	126269	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	811	10	10	10	-1.2	CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
		9887650	23423	0	None	-1	5	Guinea pig	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaThe compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig trachea	ChEMBL	407	5	1	3	4.3	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		CHEMBL124208	23423	0	None	-1	5	Guinea pig	8.6	pKi	=	8.6	Binding	The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaThe compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig trachea	ChEMBL	407	5	1	3	4.3	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		44315572	109758	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	689	11	1	7	8.3	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL306624	109758	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	689	11	1	7	8.3	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		9918479	64386	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	748	14	1	7	6.7	CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL166827	64386	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	748	14	1	7	6.7	CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		71461711	86417	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	489	9	1	4	6.2	CCC(=NO)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL2115072	86417	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	489	9	1	4	6.2	CCC(=NO)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44315231	112176	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	780	13	0	8	8.8	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL311712	112176	0	None	-1	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	780	13	0	8	8.8	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		10167532	99945	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2c(Cl)cccc2s1	10.1021/jm070289w
		CHEMBL244363	99945	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2c(Cl)cccc2s1	10.1021/jm070289w
		18393120	12032	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	502	5	2	4	4.0	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL106404	12032	0	None	10	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	502	5	2	4	4.0	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44281415	106471	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	702	12	1	5	9.2	CO/N=C(\COC/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL284597	106471	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	702	12	1	5	9.2	CO/N=C(\COC/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281680	125369	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	659	11	1	6	8.2	CO/N=C(\COCc1ccc2ccc(C(F)(F)F)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL34167	125369	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	659	11	1	6	8.2	CO/N=C(\COCc1ccc2ccc(C(F)(F)F)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44363909	42674	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	739	13	0	7	8.5	CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/s0960-894x(00)00702-2
		CHEMBL144223	42674	0	None	5	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	739	13	0	7	8.5	CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/s0960-894x(00)00702-2
		23625321	99083	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	536	11	3	6	3.0	CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1021/jm070289w
		CHEMBL242847	99083	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	536	11	3	6	3.0	CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1021/jm070289w
		44390529	70958	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	520	11	3	5	4.2	O=C(Nc1ccc(Oc2cccc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL180877	70958	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	520	11	3	5	4.2	O=C(Nc1ccc(Oc2cccc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44390606	71071	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	530	12	3	5	4.6	CCc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		CHEMBL181050	71071	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	530	12	3	5	4.6	CCc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		44390998	72363	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1cccc(Oc2ccccc2)c1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL183232	72363	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1cccc(Oc2ccccc2)c1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44390535	129595	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	576	14	3	7	3.9	COc1cc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc(OC)c1	10.1016/j.bmcl.2004.11.045
		CHEMBL360546	129595	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	576	14	3	7	3.9	COc1cc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc(OC)c1	10.1016/j.bmcl.2004.11.045
		44390588	130484	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	544	12	3	5	5.2	CC(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		CHEMBL362201	130484	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	544	12	3	5	5.2	CC(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		44314597	111128	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	599	10	0	5	7.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL310019	111128	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	599	10	0	5	7.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44391006	70850	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	485	11	2	4	3.4	O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.11.045
		CHEMBL180749	70850	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	485	11	2	4	3.4	O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.11.045
		44390987	71218	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	471	10	2	4	3.5	O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.11.045
		CHEMBL181329	71218	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	471	10	2	4	3.5	O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.11.045
		44390994	71610	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	438	10	2	4	2.3	CN(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL181998	71610	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	438	10	2	4	2.3	CN(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44391145	129209	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	492	10	2	4	3.1	O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1	10.1016/j.bmcl.2004.11.045
		CHEMBL360085	129209	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	492	10	2	4	3.1	O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1	10.1016/j.bmcl.2004.11.045
		3198	212292	76	None	-21	34	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	212292	76	None	-21	34	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	212292	76	None	-21	34	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		44329015	214760	0	None	-	1	Golden hamster	4.7	pKi	=	4.7	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	384	4	2	6	3.6	O=C(O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1	10.1016/0960-894X(95)00502-K
		CHEMBL97204	214760	0	None	-	1	Golden hamster	4.7	pKi	=	4.7	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	384	4	2	6	3.6	O=C(O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1	10.1016/0960-894X(95)00502-K
		138106885	173690	75	None	-1	4	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
		36314	173690	75	None	-1	4	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
		CHEMBL428647	173690	75	None	-1	4	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	nan
		441243	16608	58	None	-19	8	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	nan
		CHEMBL114	16608	58	None	-19	8	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	nan
		44314533	112456	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	710	12	0	6	7.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL312539	112456	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	710	12	0	6	7.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44314482	110586	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL309087	110586	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44281516	106658	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	608	11	1	5	8.0	CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL285929	106658	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	608	11	1	5	8.0	CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281333	119500	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	611	11	1	7	7.6	CO/N=C(\COCc1ccc2sc(C)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33046	119500	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	611	11	1	7	7.6	CO/N=C(\COCc1ccc2sc(C)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44314482	110586	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL309087	110586	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		10078301	126010	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	681	12	0	5	8.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL343447	126010	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	681	12	0	5	8.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44314482	110586	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		CHEMBL309087	110586	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		44314482	110586	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL309087	110586	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		10394952	111526	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	696	12	0	6	7.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL310703	111526	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	696	12	0	6	7.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		10417108	106876	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Tested for binding affinity of compound against Tachykinin receptor 2Tested for binding affinity of compound against Tachykinin receptor 2	ChEMBL	676	11	1	5	8.7	CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL287454	106876	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Tested for binding affinity of compound against Tachykinin receptor 2Tested for binding affinity of compound against Tachykinin receptor 2	ChEMBL	676	11	1	5	8.7	CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		10250427	114211	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	400	4	3	6	4.2	CC(C)c1nc2[nH]c(N3CCC(C)(O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL318198	114211	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	400	4	3	6	4.2	CC(C)c1nc2[nH]c(N3CCC(C)(O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44266599	11418	0	None	-97	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	440	8	2	4	5.2	CC[C@@H](NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		CHEMBL10303	11418	0	None	-97	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	440	8	2	4	5.2	CC[C@@H](NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		44380277	66019	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	702	13	1	5	9.3	C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL170325	66019	0	None	-2	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	702	13	1	5	9.3	C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44314548	109686	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	663	11	0	7	7.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL306052	109686	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	663	11	0	7	7.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44337201	115389	0	None	-245	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	592	7	1	4	5.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL320548	115389	0	None	-245	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	592	7	1	4	5.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44337308	12218	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	600	7	1	4	5.6	O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		CHEMBL107407	12218	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	600	7	1	4	5.6	O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		44282003	106887	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	689	11	1	5	8.6	CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL287523	106887	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	689	11	1	5	8.6	CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		9874473	48582	0	None	-16	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		CHEMBL149326	48582	0	None	-16	3	Human	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		10600223	186247	0	None	-4	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	464	7	2	4	5.2	CC[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		CHEMBL47408	186247	0	None	-4	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	464	7	2	4	5.2	CC[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		44329340	215199	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	462	5	3	6	5.3	CC(C)c1nc2[nH]c(N3CCC(O)(c4ccccc4)CC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL99823	215199	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	462	5	3	6	5.3	CC(C)c1nc2[nH]c(N3CCC(O)(c4ccccc4)CC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		657255	205863	34	None	-17	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		CHEMBL588119	205863	34	None	-17	15	Human	5.6	pKi	=	5.6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	nan
		44380092	127139	0	None	-12	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	1	6	7.2	CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL353162	127139	0	None	-12	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	698	12	1	6	7.2	CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44363436	42489	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	711	12	0	5	9.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL144057	42489	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	711	12	0	5	9.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44363949	127720	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	683	11	0	5	8.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL356105	127720	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	683	11	0	5	8.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		9874473	48582	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		CHEMBL149326	48582	0	None	-16	3	Human	7.6	pKi	=	7.6	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		44383761	136595	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	565	10	1	3	6.4	CC(=O)NCC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/S0960-894X(00)80694-0
		CHEMBL367542	136595	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	565	10	1	3	6.4	CC(=O)NCC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/S0960-894X(00)80694-0
		86274490	166665	0	None	-1148	3	Human	4.6	pKi	=	4.6	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	392	2	0	7	3.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1	nan
		CHEMBL4106866	166665	0	None	-1148	3	Human	4.6	pKi	=	4.6	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	392	2	0	7	3.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1	nan
		10044833	114224	0	None	-43	2	Human	5.6	pKi	=	5.6	Binding	Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor	ChEMBL	372	5	2	6	3.5	CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL318254	114224	0	None	-43	2	Human	5.6	pKi	=	5.6	Binding	Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor	ChEMBL	372	5	2	6	3.5	CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44380313	64865	0	None	-15	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	647	10	1	4	8.3	O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL167409	64865	0	None	-15	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	647	10	1	4	8.3	O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		1760285	215169	3	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	366	5	1	2	5.8	CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm9602423
		CHEMBL9960	215169	3	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	366	5	1	2	5.8	CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm9602423
		1760287	11068	2	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	366	5	1	2	5.8	CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		CHEMBL10079	11068	2	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	366	5	1	2	5.8	CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		44380764	127506	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	689	11	1	5	8.6	CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL354822	127506	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	689	11	1	5	8.6	CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		10395141	211604	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	13	1	7	6.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL75367	211604	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	13	1	7	6.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44302769	168456	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1350	26	11	15	6.5	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)/C(S)=N/c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		CHEMBL413205	168456	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1350	26	11	15	6.5	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)/C(S)=N/c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NC(=O)c1ccccc1)C(N)=O	10.1021/jm00039a012
		23625324	99139	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	576	11	2	6	3.9	CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		CHEMBL243071	99139	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	576	11	2	6	3.9	CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		44305818	21567	0	None	-630	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.	ChEMBL	698	13	3	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		CHEMBL1206764	21567	0	None	-630	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.	ChEMBL	698	13	3	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		CHEMBL305119	21567	0	None	-630	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.	ChEMBL	698	13	3	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		73350089	96183	0	None	-19	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	816	9	8	9	0.5	CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC	10.1021/jm00029a007
		CHEMBL2370510	96183	0	None	-19	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	816	9	8	9	0.5	CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC	10.1021/jm00029a007
		44380289	127033	0	None	-14	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	14	0	7	7.7	CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL352364	127033	0	None	-14	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	14	0	7	7.7	CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44281784	120270	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	690	10	1	6	8.3	CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33198	120270	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	690	10	1	6	8.3	CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44434189	175605	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	576	11	3	6	3.9	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL437777	175605	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	576	11	3	6	3.9	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44577884	177552	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	604	12	3	6	3.7	COc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		CHEMBL445284	177552	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	604	12	3	6	3.7	COc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		44577896	177690	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	631	14	3	6	4.4	CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1	10.1016/j.bmcl.2008.06.102
		CHEMBL445493	177690	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	631	14	3	6	4.4	CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1	10.1016/j.bmcl.2008.06.102
		44421492	144050	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	939	14	12	12	-2.4	CC(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm040832y
		CHEMBL375214	144050	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	939	14	12	12	-2.4	CC(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm040832y
		23625786	92752	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	557	11	3	6	2.8	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ncccc2c1	10.1021/jm070289w
		CHEMBL230326	92752	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	557	11	3	6	2.8	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ncccc2c1	10.1021/jm070289w
		44390560	72167	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	570	11	3	5	5.1	O=C(Nc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL182947	72167	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	570	11	3	5	5.1	O=C(Nc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		10077178	109958	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	592	12	0	8	5.0	CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-]	10.1016/s0960-894x(02)00471-7
		CHEMBL308176	109958	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	592	12	0	8	5.0	CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-]	10.1016/s0960-894x(02)00471-7
		86274727	167562	0	None	-1047	3	Human	4.6	pKi	=	4.6	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	392	2	0	7	3.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1	nan
		CHEMBL4114280	167562	0	None	-1047	3	Human	4.6	pKi	=	4.6	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	392	2	0	7	3.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1	nan
		44434177	95953	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	548	13	4	5	4.7	NCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL236661	95953	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	548	13	4	5	4.7	NCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44329148	115717	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	359	7	4	6	3.6	CC(C)c1nc2[nH]c(NCCCN)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL321137	115717	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	359	7	4	6	3.6	CC(C)c1nc2[nH]c(NCCCN)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44314298	211921	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	682	13	1	6	6.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL78065	211921	0	None	-4	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	682	13	1	6	6.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44363990	23084	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	749	14	0	5	9.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL122643	23084	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	749	14	0	5	9.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44363912	125535	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	681	12	0	5	8.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL341843	125535	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	681	12	0	5	8.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		49863734	22105	0	None	-13	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1477	21	11	14	6.8	CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm100157m
		CHEMBL1214027	22105	0	None	-13	4	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1477	21	11	14	6.8	CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O	10.1021/jm100157m
		44314299	211924	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	739	13	1	7	5.8	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL78070	211924	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	739	13	1	7	5.8	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		52918298	65261	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	631	14	3	6	4.4	CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1	10.1016/j.bmcl.2011.01.074
		CHEMBL1683150	65261	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	631	14	3	6	4.4	CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1	10.1016/j.bmcl.2011.01.074
		44314578	211927	0	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	14	1	7	6.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL78091	211927	0	None	-13	2	Human	6.6	pKi	=	6.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	14	1	7	6.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44337289	114815	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	624	9	1	6	5.3	COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL319474	114815	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	624	9	1	6	5.3	COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44363963	128055	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	724	13	1	6	7.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL357853	128055	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	724	13	1	6	7.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44337370	114193	0	None	-147	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	700	7	1	4	7.3	O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		CHEMBL318081	114193	0	None	-147	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	700	7	1	4	7.3	O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		CHEMBL2112592	216019	0	None	1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL		None	None	None		CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O	10.1021/jm00029a007
		10837820	186013	0	None	-38	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	463	7	1	3	6.8	CC[C@H](NC(=O)c1c(CN2CCCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		CHEMBL47275	186013	0	None	-38	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	463	7	1	3	6.8	CC[C@H](NC(=O)c1c(CN2CCCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		2131	10272	69	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	380	5	1	2	6.1	CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		6604009	10272	69	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	380	5	1	2	6.1	CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		CHEMBL10284	10272	69	None	-34	2	Human	6.6	pKi	=	6.6	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	380	5	1	2	6.1	CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		10619783	11454	1	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	380	5	1	2	6.1	CC[C@@H](NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		CHEMBL10334	11454	1	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	380	5	1	2	6.1	CC[C@@H](NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		44337324	13483	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	688	8	3	5	5.3	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL108364	13483	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	688	8	3	5	5.3	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44281771	106416	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	630	14	1	8	6.7	CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL284269	106416	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	630	14	1	8	6.7	CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44363962	42704	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	753	14	0	7	8.7	CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/s0960-894x(00)00702-2
		CHEMBL144249	42704	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	753	14	0	7	8.7	CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1	10.1016/s0960-894x(00)00702-2
		44314871	112470	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	712	12	0	7	6.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL312573	112470	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	712	12	0	7	6.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		23625783	99637	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	663	11	4	5	3.5	O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(I)cc2)CCCC1	10.1021/jm070289w
		CHEMBL243933	99637	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	663	11	4	5	3.5	O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(I)cc2)CCCC1	10.1021/jm070289w
		86275688	155086	0	None	-1071	3	Human	4.6	pKi	=	4.6	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	408	2	0	7	3.6	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1	nan
		CHEMBL3936869	155086	0	None	-1071	3	Human	4.6	pKi	=	4.6	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	408	2	0	7	3.6	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1	nan
		44329339	119383	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	406	4	2	6	4.0	CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL330220	119383	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	406	4	2	6	4.0	CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44281744	120251	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	739	11	1	6	7.8	CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33194	120251	0	None	1	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	739	11	1	6	7.8	CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		2683	109665	25	None	-398	16	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL305906	109665	25	None	-398	16	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		CHEMBL334255	109665	25	None	-398	16	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	nan
		4529080	174272	7	None	-93	2	Human	5.5	pKi	=	5.5	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	396	5	1	4	4.5	COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm9602423
		CHEMBL429951	174272	7	None	-93	2	Human	5.5	pKi	=	5.5	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	396	5	1	4	4.5	COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm9602423
		4529080	174272	7	None	-93	2	Human	5.5	pKi	=	5.5	Binding	Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.	ChEMBL	396	5	1	4	4.5	COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm960818o
		CHEMBL429951	174272	7	None	-93	2	Human	5.5	pKi	=	5.5	Binding	Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.	ChEMBL	396	5	1	4	4.5	COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm960818o
		44329600	10987	0	None	-	1	Golden hamster	4.5	pKi	=	4.5	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	340	3	1	5	3.9	Clc1ccc(Nc2nc(N3CCOCC3)nc3ccccc23)cc1	10.1016/0960-894X(95)00502-K
		CHEMBL100264	10987	0	None	-	1	Golden hamster	4.5	pKi	=	4.5	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	340	3	1	5	3.9	Clc1ccc(Nc2nc(N3CCOCC3)nc3ccccc23)cc1	10.1016/0960-894X(95)00502-K
		44337173	13461	0	None	30	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	582	7	2	5	4.6	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL108350	13461	0	None	30	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	582	7	2	5	4.6	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44281650	120574	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	651	11	1	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33243	120574	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	651	11	1	7	6.5	CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44282002	132284	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	657	13	1	8	6.3	CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL36462	132284	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	657	13	1	8	6.3	CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		9810288	210470	0	None	-8	2	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		CHEMBL67508	210470	0	None	-8	2	Guinea pig	8.5	pKi	=	8.5	Binding	In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2	ChEMBL	697	12	1	6	6.1	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00340-2
		44315421	112505	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	765	14	1	8	7.4	CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL312612	112505	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	765	14	1	8	7.4	CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		44380090	127498	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	684	13	0	6	7.0	COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL354771	127498	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	684	13	0	6	7.0	COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		25109291	198165	10	None	-72	8	Human	8.5	pKi	=	8.5	Binding	Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		CHEMBL519240	198165	10	None	-72	8	Human	8.5	pKi	=	8.5	Binding	Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor	ChEMBL	327	1	2	6	1.7	Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1	10.1021/jm8007618
		44577892	178602	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	620	12	3	6	4.4	CSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL446853	178602	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	620	12	3	6	4.4	CSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		11285910	148817	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	727	8	5	7	1.1	CS(=O)(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL387700	148817	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	727	8	5	7	1.1	CS(=O)(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		11181079	170338	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	580	6	6	5	1.5	N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm040832y
		CHEMBL420308	170338	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	580	6	6	5	1.5	N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm040832y
		11296497	175690	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	580	6	6	5	1.5	N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm040832y
		CHEMBL438559	175690	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	580	6	6	5	1.5	N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm040832y
		23626109	173469	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	576	11	4	6	3.6	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(O)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL428217	173469	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	576	11	4	6	3.6	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(O)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		44342780	116934	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	604	6	6	4	3.0	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CN1	10.1021/jm011127h
		CHEMBL323677	116934	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	604	6	6	4	3.0	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CN1	10.1021/jm011127h
		44343083	117171	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	585	6	5	5	2.6	O=C1CCC(=O)N[C@@H](CC2CNc3ccc(F)cc32)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm011127h
		CHEMBL324313	117171	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	585	6	5	5	2.6	O=C1CCC(=O)N[C@@H](CC2CNc3ccc(F)cc32)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm011127h
		11181079	170338	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	580	6	6	5	1.5	N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm011127h
		CHEMBL420308	170338	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	580	6	6	5	1.5	N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm011127h
		11296497	175690	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	580	6	6	5	1.5	N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm011127h
		CHEMBL438559	175690	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	580	6	6	5	1.5	N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O	10.1021/jm011127h
		44380131	64387	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	746	14	0	7	6.8	CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL166828	64387	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	746	14	0	7	6.8	CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44337330	12104	0	None	6	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	649	8	2	5	4.8	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL106816	12104	0	None	6	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	649	8	2	5	4.8	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		53322827	65259	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	657	12	3	6	4.6	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1F	10.1016/j.bmcl.2011.01.074
		CHEMBL1683148	65259	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	657	12	3	6	4.6	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1F	10.1016/j.bmcl.2011.01.074
		44337266	12070	0	None	27	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	564	7	1	4	5.3	O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		CHEMBL106608	12070	0	None	27	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	564	7	1	4	5.3	O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		44337313	115380	0	None	7	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	592	7	1	4	5.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL320487	115380	0	None	7	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	592	7	1	4	5.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44380132	103202	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	730	14	0	6	7.2	CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL262053	103202	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	730	14	0	6	7.2	CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		9914111	203478	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	504	10	1	3	6.5	CCC(O)(CC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL56481	203478	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	504	10	1	3	6.5	CCC(O)(CC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44315590	174587	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	774	14	1	8	7.5	CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21	10.1016/s0960-894x(02)00462-6
		CHEMBL430609	174587	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	774	14	1	8	7.5	CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21	10.1016/s0960-894x(02)00462-6
		22405764	203928	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	490	10	1	3	6.1	CCCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL56788	203928	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	490	10	1	3	6.1	CCCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		23626252	99337	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	576	12	4	6	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC2CCOCC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL243278	99337	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	576	12	4	6	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC2CCOCC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		23625637	157705	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	613	11	4	5	3.8	Cc1cc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)ccc1Br	10.1021/jm070289w
		CHEMBL395774	157705	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	613	11	4	5	3.8	Cc1cc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)ccc1Br	10.1021/jm070289w
		10025437	22413	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	425	5	1	3	4.5	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1	10.1021/jm00019a006
		CHEMBL122169	22413	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	425	5	1	3	4.5	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1	10.1021/jm00019a006
		10048714	23365	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	437	6	1	4	4.3	COc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1	10.1021/jm00019a006
		CHEMBL124013	23365	0	None	-	1	Rat	8.4	pKi	=	8.4	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	437	6	1	4	4.3	COc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1	10.1021/jm00019a006
		44301859	206591	0	None	35481	2	Rat	8.4	pKi	=	8.4	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400	6	2	3	3.5	[O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		CHEMBL59413	206591	0	None	35481	2	Rat	8.4	pKi	=	8.4	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400	6	2	3	3.5	[O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		10305816	10991	1	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	736	16	2	6	6.9	O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		CHEMBL100298	10991	1	None	-	1	Human	8.4	pKi	=	8.4	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	736	16	2	6	6.9	O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		44434193	95346	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	589	11	3	6	3.8	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1	10.1016/j.bmcl.2007.06.053
		CHEMBL235431	95346	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	589	11	3	6	3.8	CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1	10.1016/j.bmcl.2007.06.053
		44434185	96288	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	560	11	3	5	4.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL237304	96288	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	560	11	3	5	4.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44577887	176405	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	646	15	3	6	4.9	CCCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		CHEMBL443691	176405	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	646	15	3	6	4.9	CCCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		44577897	176713	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	12	3	5	4.3	O=C(/C=C/c1ccccc1F)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		CHEMBL444142	176713	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	12	3	5	4.3	O=C(/C=C/c1ccccc1F)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1	10.1016/j.bmcl.2008.06.102
		44577888	180654	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	13	3	6	4.1	CCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL453961	180654	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	618	13	3	6	4.1	CCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		71449112	85674	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	682	10	8	7	0.3	O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		CHEMBL2112926	85674	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	682	10	8	7	0.3	O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		53326714	65258	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	673	12	3	6	5.2	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1Cl	10.1016/j.bmcl.2011.01.074
		CHEMBL1683147	65258	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	673	12	3	6	5.2	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1Cl	10.1016/j.bmcl.2011.01.074
		44421495	91944	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	920	15	14	15	-4.1	O=C1CC(NC(=O)[C@@H](O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		CHEMBL225264	91944	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	920	15	14	15	-4.1	O=C1CC(NC(=O)[C@@H](O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm040832y
		10372391	16621	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	679	9	9	6	0.1	N=C(N)NCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm011127h
		CHEMBL114068	16621	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	679	9	9	6	0.1	N=C(N)NCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm011127h
		44342904	17298	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	676	9	6	9	0.3	O=C(Cn1cnnn1)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)NC1=O	10.1021/jm011127h
		CHEMBL116871	17298	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	676	9	6	9	0.3	O=C(Cn1cnnn1)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)NC1=O	10.1021/jm011127h
		44314502	211576	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	712	12	1	7	5.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL75018	211576	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	712	12	1	7	5.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		23625326	156158	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1sc2ccccc2c1Cl	10.1021/jm070289w
		CHEMBL394543	156158	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	596	11	3	6	4.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1sc2ccccc2c1Cl	10.1021/jm070289w
		44391011	71145	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1cccc(Oc2ccccc2)c1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL181291	71145	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1cccc(Oc2ccccc2)c1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44337467	116992	0	None	-17	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	821	13	2	7	7.8	O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1	10.1016/s0960-894x(02)00645-5
		CHEMBL323741	116992	0	None	-17	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	821	13	2	7	7.8	O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1	10.1016/s0960-894x(02)00645-5
		44391005	129109	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	438	10	2	4	2.3	CN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL359885	129109	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	438	10	2	4	2.3	CN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44391123	129137	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	471	10	2	4	3.5	O=C(N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccccc1-c1ccccc1	10.1016/j.bmcl.2004.11.045
		CHEMBL360023	129137	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	471	10	2	4	3.5	O=C(N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccccc1-c1ccccc1	10.1016/j.bmcl.2004.11.045
		86275685	152056	0	None	-416	2	Human	4.5	pKi	=	4.5	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	392	2	0	7	3.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)C3C)n1	nan
		CHEMBL3913001	152056	0	None	-416	2	Human	4.5	pKi	=	4.5	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	392	2	0	7	3.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)C3C)n1	nan
		10022196	215066	0	None	-45	2	Human	5.5	pKi	=	5.5	Binding	Inhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cellsInhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	372	4	2	6	3.7	CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL98977	215066	0	None	-45	2	Human	5.5	pKi	=	5.5	Binding	Inhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cellsInhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	372	4	2	6	3.7	CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44314503	211772	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	698	12	1	7	5.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL76704	211772	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	698	12	1	7	5.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		9931729	107770	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	416	6	2	4	3.2	O=S(=O)(CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		CHEMBL294336	107770	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	416	6	2	4	3.2	O=S(=O)(CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		44301695	208168	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	382	6	2	3	4.1	Cc1ccccc1OCC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1016/S0960-894X(01)80541-2
		CHEMBL60459	208168	0	None	-	1	Rat	7.5	pKi	=	7.5	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	382	6	2	3	4.1	Cc1ccccc1OCC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1	10.1016/S0960-894X(01)80541-2
		10122872	114538	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	704	16	2	6	5.5	O=C(c1ccccc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		CHEMBL319154	114538	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	704	16	2	6	5.5	O=C(c1ccccc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		44434195	95369	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	652	17	3	5	6.6	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21	10.1016/j.bmcl.2007.06.053
		CHEMBL235574	95369	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	652	17	3	5	6.6	CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21	10.1016/j.bmcl.2007.06.053
		44434186	161572	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	576	12	3	5	5.3	CC(C)N(CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(C)C	10.1016/j.bmcl.2007.06.053
		CHEMBL400209	161572	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	576	12	3	5	5.3	CC(C)N(CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(C)C	10.1016/j.bmcl.2007.06.053
		44391033	130336	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	487	11	2	5	3.1	CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL361815	130336	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	487	11	2	5	3.1	CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44390451	172964	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	532	12	3	6	4.1	COc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		CHEMBL426421	172964	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	532	12	3	6	4.1	COc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		44391026	130690	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL362800	130690	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL2111789	215998	0	None	3	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL		None	None	None		CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O	10.1021/jm00029a007
		44266551	105104	0	None	-58	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	394	6	1	2	6.3	CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](CC)c1ccccc1	10.1021/jm980633c
		CHEMBL275017	105104	0	None	-58	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	394	6	1	2	6.3	CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](CC)c1ccccc1	10.1021/jm980633c
		10626894	16694	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	571	6	5	4	3.3	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1	10.1021/jm0010217
		CHEMBL114442	16694	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	571	6	5	4	3.3	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1	10.1021/jm0010217
		44434162	152600	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	489	8	3	4	4.3	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NC2CC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL391710	152600	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	489	8	3	4	4.3	O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NC2CC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44434163	153638	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	534	11	3	5	4.1	CN(C)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL392523	153638	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	534	11	3	5	4.1	CN(C)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44434160	174127	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	4	5	4.1	CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O	10.1016/j.bmcl.2007.06.053
		CHEMBL429452	174127	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	4	5	4.1	CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O	10.1016/j.bmcl.2007.06.053
		10626894	16694	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	571	6	5	4	3.3	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1	10.1021/jm011127h
		CHEMBL114442	16694	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	571	6	5	4	3.3	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1	10.1021/jm011127h
		10985363	17294	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	703	9	5	6	3.6	C=CCOC(=O)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N1	10.1021/jm011127h
		CHEMBL116855	17294	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	703	9	5	6	3.6	C=CCOC(=O)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N1	10.1021/jm011127h
		10875451	117135	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	565	6	5	4	2.6	O=C1CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL324106	117135	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	565	6	5	4	2.6	O=C1CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		448537	167029	89	None	-26	25	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	167029	89	None	-26	25	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		44390446	71238	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	550	12	3	5	4.5	O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL181359	71238	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	550	12	3	5	4.5	O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		86275451	166872	0	None	-4466	3	Human	4.5	pKi	=	4.5	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	420	4	0	8	3.8	CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1	nan
		CHEMBL4108623	166872	0	None	-4466	3	Human	4.5	pKi	=	4.5	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	420	4	0	8	3.8	CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1	nan
		10668461	86238	0	None	-181	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	396	6	1	3	5.8	CC[C@H](NC(=O)c1c(OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		CHEMBL2113673	86238	0	None	-181	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	396	6	1	3	5.8	CC[C@H](NC(=O)c1c(OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		44363936	26807	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	782	14	1	7	9.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL130354	26807	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	782	14	1	7	9.0	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		10552329	174823	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	470	6	2	4	5.5	C[C@H](NC(=O)c1c(CN2CCC(N)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		CHEMBL432301	174823	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	470	6	2	4	5.5	C[C@H](NC(=O)c1c(CN2CCC(N)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		9874473	48582	0	None	-16	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		CHEMBL149326	48582	0	None	-16	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		44314504	109693	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	682	12	0	6	6.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL306121	109693	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	682	12	0	6	6.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		22405732	203174	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	462	8	1	3	5.3	CC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL56274	203174	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	462	8	1	3	5.3	CC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		11496610	10847	13	None	2	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor	ChEMBL	476	4	1	5	5.8	CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C	10.1021/jm801572m
		5582	10847	13	None	2	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor	ChEMBL	476	4	1	5	5.8	CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C	10.1021/jm801572m
		CHEMBL474991	10847	13	None	2	2	Human	6.5	pKi	=	6.5	Binding	Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor	ChEMBL	476	4	1	5	5.8	CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C	10.1021/jm801572m
		73353047	96181	0	None	-1	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	746	6	8	9	-1.1	COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1	10.1021/jm00029a007
		CHEMBL2370509	96181	0	None	-1	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	746	6	8	9	-1.1	COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1	10.1021/jm00029a007
		44281358	105039	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	674	11	1	4	9.5	CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL274557	105039	0	None	-3	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	674	11	1	4	9.5	CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		2812	11551	101	None	-28	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	11551	101	None	-28	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		44314868	162477	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	705	13	3	5	7.1	NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		CHEMBL405129	162477	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	705	13	3	5	7.1	NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		44314867	164106	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	705	13	3	5	7.1	NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		CHEMBL407749	164106	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	705	13	3	5	7.1	NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		44329374	215065	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	430	6	2	7	4.5	COC1(OC)CCN(c2nc(Nc3ccc(Cl)cc3)c3[nH]c(C(C)C)nc3n2)CC1	10.1016/0960-894X(95)00502-K
		CHEMBL98976	215065	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	430	6	2	7	4.5	COC1(OC)CCN(c2nc(Nc3ccc(Cl)cc3)c3[nH]c(C(C)C)nc3n2)CC1	10.1016/0960-894X(95)00502-K
		44329484	214747	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	344	6	3	5	4.7	CCCNc1nc(Nc2ccc(Cl)cc2)c2[nH]c(C(C)C)nc2n1	10.1016/0960-894X(95)00502-K
		CHEMBL97140	214747	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	344	6	3	5	4.7	CCCNc1nc(Nc2ccc(Cl)cc2)c2[nH]c(C(C)C)nc2n1	10.1016/0960-894X(95)00502-K
		44281572	117169	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	705	10	2	6	8.7	CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32431	117169	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	705	10	2	6	8.7	CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		9874473	48582	0	None	-16	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		CHEMBL149326	48582	0	None	-16	3	Human	7.5	pKi	=	7.5	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		9852904	123815	0	None	-128	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	677	10	1	6	5.9	CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm020094i
		CHEMBL339051	123815	0	None	-128	3	Human	7.5	pKi	=	7.5	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	677	10	1	6	5.9	CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm020094i
		2110	9743	38	None	-138	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm900948q
		219077	9743	38	None	-138	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm900948q
		3480	9743	38	None	-138	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm900948q
		CHEMBL346178	9743	38	None	-138	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm900948q
		DB04872	9743	38	None	-138	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm900948q
		44380474	65557	0	None	-13	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	678	12	2	5	8.2	CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL168769	65557	0	None	-13	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	678	12	2	5	8.2	CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44314481	211715	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	662	10	2	5	8.5	O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		CHEMBL76334	211715	0	None	-10	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	662	10	2	5	8.5	O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		86275686	153944	0	None	-851	2	Human	4.4	pKi	=	4.4	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	392	2	0	7	3.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)C3C)n1	nan
		CHEMBL3927872	153944	0	None	-851	2	Human	4.4	pKi	=	4.4	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	392	2	0	7	3.1	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)C3C)n1	nan
		86274728	167735	0	None	-1380	2	Human	4.4	pKi	=	4.4	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	394	2	0	7	2.7	Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1	nan
		CHEMBL4115594	167735	0	None	-1380	2	Human	4.4	pKi	=	4.4	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	394	2	0	7	2.7	Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1	nan
		44314865	211892	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	738	13	0	6	8.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL77752	211892	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	738	13	0	6	8.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		9874473	48582	0	None	-16	3	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		CHEMBL149326	48582	0	None	-16	3	Human	7.4	pKi	=	7.4	Binding	In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand	ChEMBL	659	10	0	4	8.4	CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm030197g
		2132	10516	58	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1016/j.bmcl.2011.02.033
		5311424	10516	58	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1016/j.bmcl.2011.02.033
		CHEMBL10188	10516	58	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1016/j.bmcl.2011.02.033
		2089	9542	28	None	-3548	5	Guinea pig	5.4	pKi	=	5.4	Binding	Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor	ChEMBL		None	None	None		None	10.1021/jm00073a022
		3795	9542	28	None	-3548	5	Guinea pig	5.4	pKi	=	5.4	Binding	Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor	ChEMBL		None	None	None		None	10.1021/jm00073a022
		5311311	9542	28	None	-3548	5	Guinea pig	5.4	pKi	=	5.4	Binding	Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor	ChEMBL		None	None	None		None	10.1021/jm00073a022
		CHEMBL217406	9542	28	None	-3548	5	Guinea pig	5.4	pKi	=	5.4	Binding	Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor	ChEMBL		None	None	None		None	10.1021/jm00073a022
		86274964	167126	0	None	-758	2	Human	4.4	pKi	=	4.4	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	374	2	0	7	3.0	Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1	nan
		CHEMBL4110770	167126	0	None	-758	2	Human	4.4	pKi	=	4.4	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	374	2	0	7	3.0	Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1	nan
		44281485	122036	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	616	12	1	5	8.3	CO/N=C(\COCc1ccc(-c2ccccc2)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33479	122036	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	616	12	1	5	8.3	CO/N=C(\COCc1ccc(-c2ccccc2)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44314873	211569	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	12	1	7	6.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL74918	211569	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	726	12	1	7	6.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		73351579	96180	0	None	2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	800	7	9	9	0.1	CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O	10.1021/jm00029a007
		CHEMBL2370507	96180	0	None	2	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	800	7	9	9	0.1	CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O	10.1021/jm00029a007
		44314945	211775	0	None	-9	2	Human	6.4	pKi	=	6.4	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	728	17	1	7	6.9	CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(00)00464-9
		CHEMBL76727	211775	0	None	-9	2	Human	6.4	pKi	=	6.4	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	728	17	1	7	6.9	CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(00)00464-9
		44363982	42440	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	683	12	0	6	7.8	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL144010	42440	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	683	12	0	6	7.8	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44364030	43421	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	711	13	1	6	8.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL144887	43421	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	711	13	1	6	8.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44434164	173831	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	13	3	5	4.9	CCN(CC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL428905	173831	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	13	3	5	4.9	CCN(CC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44380473	127562	0	None	-549	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	684	12	1	6	6.5	CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL355429	127562	0	None	-549	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	684	12	1	6	6.5	CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44314476	111859	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		CHEMBL311387	111859	0	None	-12	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		44434166	95527	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	534	12	4	5	4.3	NCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL236248	95527	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	534	12	4	5	4.3	NCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		90663623	113487	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	628	15	4	7	3.4	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc2C1	10.1016/j.bmcl.2007.06.053
		CHEMBL3143849	113487	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	628	15	4	7	3.4	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc2C1	10.1016/j.bmcl.2007.06.053
		CHEMBL117039	215340	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL		None	None	None		O=C1C[C@@H](C(=O)O)NC(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		2132	10516	58	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm5017413
		5311424	10516	58	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm5017413
		CHEMBL10188	10516	58	None	-97	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	10.1021/jm5017413
		10875000	170651	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	518	5	6	5	-0.2	NC(=O)[C@@H]1CNC(=O)CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1	10.1021/jm011127h
		CHEMBL420685	170651	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	518	5	6	5	-0.2	NC(=O)[C@@H]1CNC(=O)CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1	10.1021/jm011127h
		44315210	109695	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	747	14	0	8	8.0	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL306124	109695	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	747	14	0	8	8.0	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		44281723	106403	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	596	11	1	5	8.0	CO/N=C(\COCc1ccc(C(C)(C)C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL284145	106403	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	596	11	1	5	8.0	CO/N=C(\COCc1ccc(C(C)(C)C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281666	115982	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	635	10	1	5	7.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32163	115982	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	635	10	1	5	7.5	CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281958	116464	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	646	10	1	6	6.4	CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32273	116464	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	646	10	1	6	6.4	CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281787	169978	0	None	14	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	597	11	1	6	6.2	CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL418224	169978	0	None	14	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	597	11	1	6	6.2	CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44363908	42557	0	None	4	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	681	11	0	5	8.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL144116	42557	0	None	4	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	681	11	0	5	8.2	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44315589	211617	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	804	16	1	9	7.2	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL75478	211617	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	804	16	1	9	7.2	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		44315589	211617	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes	ChEMBL	804	16	1	9	7.2	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1021/acs.jmedchem.9b00017
		CHEMBL75478	211617	0	None	-2	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes	ChEMBL	804	16	1	9	7.2	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1021/acs.jmedchem.9b00017
		23625634	99356	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	567	12	4	6	3.4	CSc1ccc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc1	10.1021/jm070289w
		CHEMBL243503	99356	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	567	12	4	6	3.4	CSc1ccc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc1	10.1021/jm070289w
		44380414	64929	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	699	12	2	7	5.9	CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL167994	64929	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	699	12	2	7	5.9	CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		9956370	180501	0	None	53	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	470	6	1	4	5.5	CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NC2CCCCC2)CC1	10.1021/jm000501v
		CHEMBL45362	180501	0	None	53	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	470	6	1	4	5.5	CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NC2CCCCC2)CC1	10.1021/jm000501v
		44380279	64593	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	761	15	1	7	6.3	CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL166975	64593	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	761	15	1	7	6.3	CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		49863732	22103	0	None	-24	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1266	18	10	12	6.1	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		CHEMBL1214025	22103	0	None	-24	4	Rat	8.4	pKi	=	8.4	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1266	18	10	12	6.1	CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		53325456	65260	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	630	14	3	5	5.1	CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2011.01.074
		CHEMBL1683149	65260	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	630	14	3	5	5.1	CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2011.01.074
		11800732	187375	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	546	8	1	4	7.2	CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		CHEMBL47544	187375	0	None	-3	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	546	8	1	4	7.2	CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		23626411	99006	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	673	12	3	7	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL242624	99006	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	673	12	3	7	3.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		10392319	202978	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	532	12	1	3	7.3	CCCC(O)(CCC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL56143	202978	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	532	12	1	3	7.3	CCCC(O)(CCC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44315591	211753	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	746	13	1	8	6.9	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL76529	211753	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	746	13	1	8	6.9	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		44380337	64209	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	735	14	0	8	7.1	CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL165465	64209	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	735	14	0	8	7.1	CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		23626254	99996	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	594	16	6	7	2.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CCO)CCO)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL244766	99996	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	594	16	6	7	2.9	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CCO)CCO)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		10280686	149855	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	546	11	3	6	3.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2o1	10.1021/jm070289w
		CHEMBL389525	149855	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	546	11	3	6	3.0	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2o1	10.1021/jm070289w
		44315573	110573	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	707	12	1	7	8.3	CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL308983	110573	0	None	-1	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	707	12	1	7	8.3	CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00462-6
		10145229	15945	0	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	592	7	1	4	5.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL110219	15945	0	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	592	7	1	4	5.9	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44281726	116305	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	540	11	1	5	6.7	CO/N=C(\COCc1ccccc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32215	116305	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	540	11	1	5	6.7	CO/N=C(\COCc1ccccc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		22405761	205068	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	504	10	0	4	5.9	CC(=O)OCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL57589	205068	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	504	10	0	4	5.9	CC(=O)OCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		2110	9743	38	None	-138	6	Human	7.4	pKi	=	7.4	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		219077	9743	38	None	-138	6	Human	7.4	pKi	=	7.4	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		3480	9743	38	None	-138	6	Human	7.4	pKi	=	7.4	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		CHEMBL346178	9743	38	None	-138	6	Human	7.4	pKi	=	7.4	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		DB04872	9743	38	None	-138	6	Human	7.4	pKi	=	7.4	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm9602423
		44312828	111137	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	640	12	0	8	6.1	CC1=C(C(=O)Oc2ccccc2)[S+]([O-])C2C(O1)OC(COCc1ccccc1)C(OCc1ccccc1)C2OCc1ccccc1	10.1016/s0960-894x(02)00471-7
		CHEMBL310084	111137	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	640	12	0	8	6.1	CC1=C(C(=O)Oc2ccccc2)[S+]([O-])C2C(O1)OC(COCc1ccccc1)C(OCc1ccccc1)C2OCc1ccccc1	10.1016/s0960-894x(02)00471-7
		44312485	211418	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	486	9	1	8	3.8	CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2S1	10.1016/s0960-894x(02)00471-7
		CHEMBL73540	211418	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	486	9	1	8	3.8	CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2S1	10.1016/s0960-894x(02)00471-7
		44312718	211564	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	502	9	1	8	2.8	CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-]	10.1016/s0960-894x(02)00471-7
		CHEMBL74882	211564	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	502	9	1	8	2.8	CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-]	10.1016/s0960-894x(02)00471-7
		44314577	166659	0	None	-16	2	Human	6.4	pKi	=	6.4	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	782	14	0	8	7.1	CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/s0960-894x(00)00464-9
		CHEMBL41068	166659	0	None	-16	2	Human	6.4	pKi	=	6.4	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	782	14	0	8	7.1	CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1	10.1016/s0960-894x(00)00464-9
		CHEMBL4521971	220757	45	None	-338	5	Human	5.4	pKi	=	5.4	Binding	Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b TACR2Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b TACR2	ChEMBL		None	None	None		Clc1cc2c(NC3CCCC3)nnc(-c3ccncc3)c2cc1Cl	10.6019/CHEMBL5212743
		2750	210840	76	None	-2	12	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	210840	76	None	-2	12	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		44380596	66126	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	706	13	1	6	8.7	COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL170727	66126	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	706	13	1	6	8.7	COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44281505	123668	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	576	11	1	5	6.9	CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33833	123668	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	576	11	1	5	6.9	CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		2090	9543	25	None	-38	4	Human	7.4	pKi	=	7.4	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		5311312	9543	25	None	-38	4	Human	7.4	pKi	=	7.4	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		CHEMBL437797	9543	25	None	-38	4	Human	7.4	pKi	=	7.4	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		None	10.1021/jm9807151
		9940831	21418	0	None	-912	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.	ChEMBL	810	13	4	9	5.7	O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		CHEMBL1205204	21418	0	None	-912	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.	ChEMBL	810	13	4	9	5.7	O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		CHEMBL65468	21418	0	None	-912	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.	ChEMBL	810	13	4	9	5.7	O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		44281334	126172	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	541	11	1	6	6.1	CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL34460	126172	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	541	11	1	6	6.1	CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44329530	119182	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	428	4	2	7	4.2	CC(C)c1nc2[nH]c(N3CCC4(CC3)OCCO4)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL329749	119182	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	428	4	2	7	4.2	CC(C)c1nc2[nH]c(N3CCC4(CC3)OCCO4)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL103634	215237	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2	ChEMBL		None	None	None		CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm9807151
		52918299	65265	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	640	13	2	6	5.4	COc1c(C(=O)NC2(C(=O)N[C@H](CCCN3CCN(CC4CCOCC4)CC3)Cc3ccccc3)CCCC2)ccc2ccccc12	10.1016/j.bmcl.2011.01.074
		CHEMBL1683154	65265	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	640	13	2	6	5.4	COc1c(C(=O)NC2(C(=O)N[C@H](CCCN3CCN(CC4CCOCC4)CC3)Cc3ccccc3)CCCC2)ccc2ccccc12	10.1016/j.bmcl.2011.01.074
		44380093	127514	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	733	13	2	6	7.8	CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL354892	127514	0	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	733	13	2	6	7.8	CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		11734825	19999	0	None	-549	2	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
		CHEMBL119126	19999	0	None	-549	2	Human	6.3	pKi	=	6.3	Binding	In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
		44363978	47264	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	697	12	1	6	7.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL148282	47264	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	697	12	1	6	7.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		22405743	107473	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	462	9	1	3	5.3	CN(CC(CCN1CCC(CCO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(98)00037-7
		CHEMBL292415	107473	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	462	9	1	3	5.3	CN(CC(CCN1CCC(CCO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(98)00037-7
		44314732	211873	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	764	12	0	6	8.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL77592	211873	0	None	-3	2	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	764	12	0	6	8.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44380413	103371	0	None	-21	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	741	15	1	7	6.2	COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL263214	103371	0	None	-21	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	741	15	1	7	6.2	COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44314487	109690	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	753	13	1	7	6.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL306097	109690	0	None	-5	2	Human	7.3	pKi	=	7.3	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	753	13	1	7	6.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		6518171	175075	55	None	-4	8	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	495	12	2	6	4.9	CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1	nan
		CHEMBL434063	175075	55	None	-4	8	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	495	12	2	6	4.9	CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1	nan
		86274731	167452	0	None	-1584	2	Human	4.3	pKi	=	4.3	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	412	2	0	7	2.9	Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1	nan
		CHEMBL4113428	167452	0	None	-1584	2	Human	4.3	pKi	=	4.3	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	412	2	0	7	2.9	Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1	nan
		3561	25849	39	None	-1	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	25849	39	None	-1	11	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		71461646	85684	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	676	11	0	5	7.6	CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL2112941	85684	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	676	11	0	5	7.6	CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL2390989	217190	16	None	-	1	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O	10.1016/j.ejmech.2013.01.044
		10390024	24726	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	471	5	1	5	3.8	Cc1ccc(S(=O)(=O)N2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1	10.1021/jm00019a006
		CHEMBL126043	24726	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	471	5	1	5	3.8	Cc1ccc(S(=O)(=O)N2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1	10.1021/jm00019a006
		44577886	178704	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	632	14	3	6	4.5	CCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		CHEMBL447011	178704	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	632	14	3	6	4.5	CCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1	10.1016/j.bmcl.2008.06.102
		44577895	195652	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	630	14	3	5	5.1	CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL507077	195652	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	630	14	3	5	5.1	CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		44374543	59669	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	773	9	5	6	3.7	O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		CHEMBL159585	59669	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	773	9	5	6	3.7	O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1016/s0960-894x(01)00841-1
		11251301	149744	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	663	7	6	6	2.0	NC1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		CHEMBL389432	149744	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	663	7	6	6	2.0	NC1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1	10.1021/jm040832y
		44343033	16582	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	685	9	4	5	5.4	O=C(N[C@H]1CCCCN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)OCc1ccccc1	10.1021/jm011127h
		CHEMBL113765	16582	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	685	9	4	5	5.4	O=C(N[C@H]1CCCCN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)OCc1ccccc1	10.1021/jm011127h
		44315422	109916	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	747	13	1	8	7.5	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		CHEMBL307877	109916	0	None	-2	3	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand	ChEMBL	747	13	1	8	7.5	CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00462-6
		9940831	21418	0	None	-1	4	Rabbit	8.3	pKi	=	8.3	Binding	Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.	ChEMBL	810	13	4	9	5.7	O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		CHEMBL1205204	21418	0	None	-1	4	Rabbit	8.3	pKi	=	8.3	Binding	Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.	ChEMBL	810	13	4	9	5.7	O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		CHEMBL65468	21418	0	None	-1	4	Rabbit	8.3	pKi	=	8.3	Binding	Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.	ChEMBL	810	13	4	9	5.7	O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		44380248	64937	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	720	13	0	7	7.3	CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL168144	64937	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	720	13	0	7	7.3	CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		10303126	159963	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	560	11	3	6	3.3	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC=CC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL397702	159963	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	560	11	3	6	3.3	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC=CC1)c1cc2ccccc2s1	10.1021/jm070289w
		44305818	21567	0	None	-1	4	Rabbit	8.3	pKi	=	8.3	Binding	Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.	ChEMBL	698	13	3	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		CHEMBL1206764	21567	0	None	-1	4	Rabbit	8.3	pKi	=	8.3	Binding	Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.	ChEMBL	698	13	3	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		CHEMBL305119	21567	0	None	-1	4	Rabbit	8.3	pKi	=	8.3	Binding	Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.	ChEMBL	698	13	3	8	4.3	CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12	10.1016/S0960-894X(96)00604-X
		10696939	188377	0	None	-3	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	506	8	1	4	6.3	CC[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		CHEMBL47713	188377	0	None	-3	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	506	8	1	4	6.3	CC[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		118724122	123189	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1296	40	16	22	-3.0	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)Nc1ccc([N+](=O)[O-])c2nonc12)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm401823z
		CHEMBL3360201	123189	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	1296	40	16	22	-3.0	CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)Nc1ccc([N+](=O)[O-])c2nonc12)[C@@H](C)O)C(C)C)C(N)=O	10.1021/jm401823z
		44380081	64882	0	None	-100	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	738	13	1	7	6.3	CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL167546	64882	0	None	-100	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	738	13	1	7	6.3	CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44380733	65390	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	720	14	1	6	8.7	COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL168437	65390	0	None	-7	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	720	14	1	6	8.7	COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44390607	70678	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	558	11	3	5	5.3	CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		CHEMBL180539	70678	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	558	11	3	5	5.3	CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		44384147	137471	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	524	9	1	3	6.3	CN(CC(CCN1CCC(CO)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/S0960-894X(00)80694-0
		CHEMBL368372	137471	0	None	-	1	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes	ChEMBL	524	9	1	3	6.3	CN(CC(CCN1CCC(CO)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/S0960-894X(00)80694-0
		44434188	96381	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	574	11	3	5	5.1	CN1CCCC1CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL237517	96381	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	574	11	3	5	5.1	CN1CCCC1CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44434161	97036	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	4	5	4.1	CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O	10.1016/j.bmcl.2007.06.053
		CHEMBL238392	97036	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	4	5	4.1	CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O	10.1016/j.bmcl.2007.06.053
		44434170	161208	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	566	15	4	7	2.8	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL398982	161208	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	566	15	4	7	2.8	NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCC1	10.1016/j.bmcl.2007.06.053
		44390506	70278	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	552	12	3	5	4.1	O=C(Nc1ccc(OCc2cc(F)cc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL179986	70278	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	552	12	3	5	4.1	O=C(Nc1ccc(OCc2cc(F)cc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44391084	71101	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL181153	71101	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44391034	71347	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL181581	71347	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44390534	71626	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	584	12	3	5	4.9	O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL182082	71626	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	584	12	3	5	4.9	O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44391022	128802	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1ccccc1Oc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL359487	128802	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	502	11	3	5	4.1	O=C(Nc1ccccc1Oc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44331207	174754	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	579	12	3	6	3.8	O=C(NCCc1c[nH]c2ccccc12)c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		CHEMBL431838	174754	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2	ChEMBL	579	12	3	6	3.8	O=C(NCCc1c[nH]c2ccccc12)c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12	10.1016/s0960-894x(02)00539-5
		44312406	164122	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	702	13	0	8	7.2	O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1(=O)=O)c1ccccc1	10.1016/s0960-894x(02)00471-7
		CHEMBL407769	164122	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	702	13	0	8	7.2	O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1(=O)=O)c1ccccc1	10.1016/s0960-894x(02)00471-7
		10717843	107881	0	None	-15	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	437	7	1	3	6.1	CC(C)[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		CHEMBL295059	107881	0	None	-15	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	437	7	1	3	6.1	CC(C)[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm000501v
		25222441	203920	0	None	-104	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	589	8	0	3	6.4	CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm900948q
		CHEMBL567849	203920	0	None	-104	4	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	589	8	0	3	6.4	CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm900948q
		44314872	103647	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	740	13	1	7	6.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL265499	103647	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	740	13	1	7	6.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		44329351	214897	0	None	13	2	Golden hamster	6.3	pKi	=	6.3	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	358	4	2	6	3.1	CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL97958	214897	0	None	13	2	Golden hamster	6.3	pKi	=	6.3	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	358	4	2	6	3.1	CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		148124	213878	86	None	-	1	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	nan
		CHEMBL3545252	213878	86	None	-	1	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	nan
		CHEMBL92	213878	86	None	-	1	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	nan
		44363979	127761	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	711	13	1	6	8.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL356268	127761	0	None	-2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	711	13	1	6	8.3	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		138106918	202265	42	None	-	1	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	nan
		5311497	202265	42	None	-	1	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	nan
		CHEMBL553025	202265	42	None	-	1	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	nan
		6918276	22383	7	None	-56	8	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		CHEMBL1221512	22383	7	None	-56	8	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	559	18	4	9	1.7	CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS	nan
		44281788	106762	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	583	11	2	6	5.9	CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL286640	106762	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	583	11	2	6	5.9	CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		10044833	114224	0	None	43	2	Golden hamster	7.3	pKi	=	7.3	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	372	5	2	6	3.5	CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL318254	114224	0	None	43	2	Golden hamster	7.3	pKi	=	7.3	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	372	5	2	6	3.5	CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44329517	215056	0	None	-36	2	Human	6.3	pKi	=	6.3	Binding	Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor	ChEMBL	387	4	1	6	3.1	CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O	10.1016/0960-894X(95)00502-K
		CHEMBL98929	215056	0	None	-36	2	Human	6.3	pKi	=	6.3	Binding	Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor	ChEMBL	387	4	1	6	3.1	CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O	10.1016/0960-894X(95)00502-K
		44329149	114333	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	392	6	3	5	5.4	CC(C)c1nc2[nH]c(NCc3ccccc3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL318880	114333	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	392	6	3	5	5.4	CC(C)c1nc2[nH]c(NCc3ccccc3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		11057	182928	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	182928	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	182928	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	182928	23	None	-1	20	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		44314454	112394	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	758	12	0	6	7.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL312295	112394	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	758	12	0	6	7.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		3823	56995	42	None	-36	11	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		76973198	56995	42	None	-36	11	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL157101	56995	42	None	-36	11	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		44380094	65518	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	719	13	2	6	7.6	NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL168584	65518	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	719	13	2	6	7.6	NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(02)00027-6
		44363984	42442	0	None	-4	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	735	14	0	5	9.3	C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(00)00702-2
		CHEMBL144011	42442	0	None	-4	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	735	14	0	5	9.3	C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O	10.1016/s0960-894x(00)00702-2
		15730	77893	80	None	-2	10	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		CHEMBL195437	77893	80	None	-2	10	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	206	7	1	1	4.3	CCCCCCCCc1ccc(O)cc1	nan
		44329367	215027	0	None	-	1	Golden hamster	4.2	pKi	=	4.2	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	425	5	2	6	4.0	CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1	10.1016/0960-894X(95)00502-K
		CHEMBL98760	215027	0	None	-	1	Golden hamster	4.2	pKi	=	4.2	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	425	5	2	6	4.0	CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1	10.1016/0960-894X(95)00502-K
		44329531	214866	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	384	4	2	6	4.0	CC(C)c1nc2[nH]c(N3CCC(=O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL97764	214866	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells	ChEMBL	384	4	2	6	4.0	CC(C)c1nc2[nH]c(N3CCC(=O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44364003	125773	0	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	681	11	0	5	8.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL342572	125773	0	None	-9	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	681	11	0	5	8.1	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44380080	19014	0	None	-323	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	726	14	0	5	7.5	CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL1184507	19014	0	None	-323	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	726	14	0	5	7.5	CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL352842	19014	0	None	-323	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	726	14	0	5	7.5	CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		71549913	125634	0	None	-588	3	Human	5.2	pKi	=	5.2	Binding	Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	415	3	0	6	4.6	Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1	nan
		CHEMBL3422007	125634	0	None	-588	3	Human	5.2	pKi	=	5.2	Binding	Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	415	3	0	6	4.6	Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1	nan
		44281633	106763	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	664	11	1	7	7.7	CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL286646	106763	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	664	11	1	7	7.7	CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281778	116473	0	None	4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	608	11	1	5	8.0	CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32279	116473	0	None	4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	608	11	1	5	8.0	CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281672	120301	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	596	10	1	6	6.2	CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33215	120301	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	596	10	1	6	6.2	CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		10718673	185886	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	457	6	1	4	5.4	C[C@H](NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		CHEMBL47179	185886	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	457	6	1	4	5.4	C[C@H](NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1	10.1021/jm000501v
		10321179	22338	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	443	5	1	3	4.6	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1F	10.1021/jm00019a006
		CHEMBL122019	22338	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	443	5	1	3	4.6	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1F	10.1021/jm00019a006
		10091869	119607	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	391	5	1	2	4.8	Fc1ccc2[nH]cc(CCN3CCC4(CC3)CCN(Cc3ccccc3)C4)c2c1	10.1021/jm00019a006
		CHEMBL330766	119607	0	None	-	1	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	391	5	1	2	4.8	Fc1ccc2[nH]cc(CCN3CCC4(CC3)CCN(Cc3ccccc3)C4)c2c1	10.1021/jm00019a006
		44434196	156003	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	594	11	3	5	4.8	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL394418	156003	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	594	11	3	5	4.8	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44434180	159815	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	618	17	3	5	6.5	CCCCN(CCCC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL397576	159815	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	618	17	3	5	6.5	CCCCN(CCCC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44374557	126373	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	693	11	6	6	1.9	CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1016/s0960-894x(01)00841-1
		CHEMBL346285	126373	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	693	11	6	6	1.9	CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1016/s0960-894x(01)00841-1
		44374622	126841	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	825	11	10	10	-0.8	CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
		CHEMBL350596	126841	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	825	11	10	10	-0.8	CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
		11411718	175726	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	8	6	6	2.3	O=C1C[C@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm040832y
		CHEMBL438839	175726	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	8	6	6	2.3	O=C1C[C@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm040832y
		44342797	174914	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	754	8	10	9	-0.7	O=C1C[C@H](NC(=O)[C@]2(O)C[C@@H](O)[C@@H](O)[C@H](O)C2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL432986	174914	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	754	8	10	9	-0.7	O=C1C[C@H](NC(=O)[C@]2(O)C[C@@H](O)[C@@H](O)[C@H](O)C2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		44300619	205838	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	503	10	0	4	6.4	CC/C(=N\OC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL58638	205838	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	503	10	0	4	6.4	CC/C(=N\OC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44302496	105189	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1081	23	8	14	2.5	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(N)c1ccc([N+](=O)[O-])c2nonc12)C(N)=O	10.1021/jm00039a012
		CHEMBL275499	105189	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL	1081	23	8	14	2.5	CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)c1ccccc1)C(N)c1ccc([N+](=O)[O-])c2nonc12)C(N)=O	10.1021/jm00039a012
		44380338	127254	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	14	0	7	7.7	CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL354196	127254	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	734	14	0	7	7.7	CN(C/C(=N\OCCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		44391153	71303	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	487	11	2	5	3.1	CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL181446	71303	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	487	11	2	5	3.1	CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44390553	176025	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	544	12	3	5	5.2	CC(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		CHEMBL441115	176025	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	544	12	3	5	5.2	CC(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		44434183	174191	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	560	10	3	5	4.7	O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCCCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		CHEMBL429631	174191	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	560	10	3	5	4.7	O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCCCC2)CCCCC1)c1cc2ccccc2s1	10.1016/j.bmcl.2007.06.053
		44390532	71219	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	550	12	3	5	4.5	O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL181330	71219	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	550	12	3	5	4.5	O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44390539	71338	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	530	12	3	5	4.6	CCc1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		CHEMBL181526	71338	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	530	12	3	5	4.6	CCc1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		44391105	72402	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	516	12	3	5	3.8	O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL183414	72402	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	516	12	3	5	3.8	O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		10603037	123542	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.4	O=C1CC(Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1	10.1021/jm0010217
		CHEMBL337628	123542	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.4	O=C1CC(Cc2ccccc2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1	10.1021/jm0010217
		44343099	118105	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	567	6	5	4	2.7	O=C1CC(CC2C=CC=CC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1	10.1021/jm011127h
		CHEMBL326790	118105	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	567	6	5	4	2.7	O=C1CC(CC2C=CC=CC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1	10.1021/jm011127h
		44391036	71119	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	494	9	3	5	2.1	O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCCC(O)(c2ccccc2)C1	10.1016/j.bmcl.2004.11.045
		CHEMBL181225	71119	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	494	9	3	5	2.1	O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCCC(O)(c2ccccc2)C1	10.1016/j.bmcl.2004.11.045
		44391009	129405	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL360354	129405	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		2335	18620	22	None	-3	12	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		8478	18620	22	None	-3	12	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL1182210	18620	22	None	-3	12	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		CHEMBL221753	18620	22	None	-3	12	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	nan
		176	7186	66	None	-4	31	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	7186	66	None	-4	31	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	7186	66	None	-4	31	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	7186	66	None	-4	31	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	7186	66	None	-4	31	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		3191	109635	97	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	109635	97	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		22405753	205574	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	503	10	1	3	5.5	CC(=O)NCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL58331	205574	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	503	10	1	3	5.5	CC(=O)NCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		44329163	118226	0	None	2	2	Golden hamster	5.2	pKi	=	5.2	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	344	3	2	6	2.8	Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL327531	118226	0	None	2	2	Golden hamster	5.2	pKi	=	5.2	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	344	3	2	6	2.8	Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44363925	46837	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	754	13	1	7	8.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL147924	46837	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	754	13	1	7	8.4	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		44364002	127826	0	None	-8	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	627	11	1	5	6.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL356796	127826	0	None	-8	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	627	11	1	5	6.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(N)=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		10022196	215066	0	None	45	2	Golden hamster	7.2	pKi	=	7.2	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	372	4	2	6	3.7	CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL98977	215066	0	None	45	2	Golden hamster	7.2	pKi	=	7.2	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	372	4	2	6	3.7	CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		9809876	26172	1	None	-398	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	661	10	0	5	7.9	COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm020094i
		CHEMBL129321	26172	1	None	-398	3	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells	ChEMBL	661	10	0	5	7.9	COc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1	10.1021/jm020094i
		44329351	214897	0	None	-13	2	Human	5.2	pKi	=	5.2	Binding	Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor	ChEMBL	358	4	2	6	3.1	CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		CHEMBL97958	214897	0	None	-13	2	Human	5.2	pKi	=	5.2	Binding	Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor	ChEMBL	358	4	2	6	3.1	CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1	10.1016/0960-894X(95)00502-K
		44337270	115379	0	None	4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	665	8	3	6	4.5	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		CHEMBL320486	115379	0	None	4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	665	8	3	6	4.5	Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccc(O)cc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1	10.1016/s0960-894x(02)00645-5
		44281587	60332	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	660	11	1	6	7.4	CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL160210	60332	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	660	11	1	6	7.4	CO/N=C(\CN(C)C(=O)c1ccc(N(C)C)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281342	116208	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	598	11	1	5	7.7	CO/N=C(\COCC12CC3CC(CC(C3)C1)C2)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32201	116208	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	598	11	1	5	7.7	CO/N=C(\COCC12CC3CC(CC(C3)C1)C2)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		10032406	46728	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	667	11	0	5	7.8	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL147824	46728	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	667	11	0	5	7.8	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		10484667	211334	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		CHEMBL72930	211334	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand	ChEMBL	676	11	1	5	8.7	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00463-7
		25129133	195666	0	None	-10	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1208	27	10	11	4.9	CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		CHEMBL507340	195666	0	None	-10	4	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor	ChEMBL	1208	27	10	11	4.9	CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1	10.1021/jm100157m
		44300632	108751	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	476	8	1	3	5.7	CN(CC(CCN1CCC(C(C)(C)O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(98)00037-7
		CHEMBL301437	108751	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	476	8	1	3	5.7	CN(CC(CCN1CCC(C(C)(C)O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1	10.1016/s0960-894x(98)00037-7
		10389401	123877	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	457	5	1	3	5.5	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc2ccccc12	10.1021/jm00019a006
		CHEMBL339311	123877	0	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	457	5	1	3	5.5	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc2ccccc12	10.1021/jm00019a006
		9843958	207572	1	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400	6	2	3	3.5	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		CHEMBL60064	207572	1	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon	ChEMBL	400	6	2	3	3.5	[O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1	10.1016/S0960-894X(01)80541-2
		10627614	17264	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	615	6	5	4	3.7	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1	10.1021/jm0010217
		CHEMBL116564	17264	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	615	6	5	4	3.7	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1	10.1021/jm0010217
		44434190	156297	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	588	11	3	5	5.4	CC1CCCCN1CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		CHEMBL394648	156297	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	588	11	3	5	5.4	CC1CCCCN1CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1	10.1016/j.bmcl.2007.06.053
		44577890	136875	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	632	13	3	6	4.5	CC(C)Oc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		CHEMBL367768	136875	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells	ChEMBL	632	13	3	6	4.5	CC(C)Oc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1	10.1016/j.bmcl.2008.06.102
		44374504	61623	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	825	11	10	10	-0.8	CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
		CHEMBL161288	61623	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	825	11	10	10	-0.8	CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O	10.1016/s0960-894x(01)00841-1
		11787612	91962	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	8	6	6	2.3	O=C1C[C@@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm040832y
		CHEMBL225393	91962	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells	ChEMBL	664	8	6	6	2.3	O=C1C[C@@H](NC2CCOCC2)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1	10.1021/jm040832y
		10627614	17264	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	615	6	5	4	3.7	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1	10.1021/jm011127h
		CHEMBL116564	17264	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	615	6	5	4	3.7	O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc3ccccc3c2)CN1	10.1021/jm011127h
		44343143	117203	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	665	10	7	6	1.4	NCCCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm011127h
		CHEMBL324532	117203	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	665	10	7	6	1.4	NCCCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O	10.1021/jm011127h
		9887650	23423	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cellsThe compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cells	ChEMBL	407	5	1	3	4.3	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		CHEMBL124208	23423	0	None	-6	5	Human	8.1	pKi	=	8.1	Binding	The compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cellsThe compound was tested for binding affinity against Tachykinin receptor 2 from human expressed in CHO cells	ChEMBL	407	5	1	3	4.3	O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1	10.1021/jm00019a006
		44434158	96901	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	4	5	4.1	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O	10.1016/j.bmcl.2007.06.053
		CHEMBL238181	96901	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells	ChEMBL	562	11	4	5	4.1	CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O	10.1016/j.bmcl.2007.06.053
		23625636	99596	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	557	11	4	5	3.0	O=C(Nc1ccc(F)c(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		CHEMBL243726	99596	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	557	11	4	5	3.0	O=C(Nc1ccc(F)c(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		73347011	96184	0	None	-1	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	730	6	7	8	-0.6	COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1	10.1021/jm00029a007
		CHEMBL2370511	96184	0	None	-1	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)	ChEMBL	730	6	7	8	-0.6	COc1ccc(CC2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1	10.1021/jm00029a007
		44314154	211846	0	None	-24	2	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	585	10	1	5	6.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL77265	211846	0	None	-24	2	Human	6.1	pKi	=	6.1	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	585	10	1	5	6.6	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCNCC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		1212	8443	50	None	-389	65	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	8443	50	None	-389	65	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	8443	50	None	-389	65	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	8443	50	None	-389	65	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	8443	50	None	-389	65	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		51003494	65096	0	None	-9	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor	ChEMBL	556	8	0	4	3.5	CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1	10.1016/j.bmcl.2010.12.135
		CHEMBL1682680	65096	0	None	-9	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor	ChEMBL	556	8	0	4	3.5	CN(Cc1ccc(F)cc1)C(=O)[C@@]1(c2ccc(Cl)c(Cl)c2)C[C@H]1CN1CCN(S(=O)(=O)N(C)C)CC1	10.1016/j.bmcl.2010.12.135
		86274487	166868	0	None	-691	3	Human	5.1	pKi	=	5.1	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	408	2	0	7	3.6	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1	nan
		CHEMBL4108583	166868	0	None	-691	3	Human	5.1	pKi	=	5.1	Binding	Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	408	2	0	7	3.6	Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)[C@@H]3C)n1	nan
		10479619	119664	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	465	6	1	5	4.1	COC(=O)c1cccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)c1	10.1021/jm00019a006
		CHEMBL331011	119664	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.	ChEMBL	465	6	1	5	4.1	COC(=O)c1cccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)c1	10.1021/jm00019a006
		2110	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm5017413
		219077	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm5017413
		3480	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm5017413
		CHEMBL346178	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm5017413
		DB04872	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1021/jm5017413
		44391066	70232	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	530	12	3	5	4.1	Cc1ccc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		CHEMBL179796	70232	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	530	12	3	5	4.1	Cc1ccc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1	10.1016/j.bmcl.2004.11.045
		44390533	130647	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	584	12	3	5	4.9	O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL362682	130647	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	584	12	3	5	4.9	O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44312702	109959	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	686	13	0	7	7.5	O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-])c1ccccc1	10.1016/s0960-894x(02)00471-7
		CHEMBL308177	109959	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	686	13	0	7	7.5	O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-])c1ccccc1	10.1016/s0960-894x(02)00471-7
		44312785	112191	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	502	9	1	8	2.8	CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2[S+]1[O-]	10.1016/s0960-894x(02)00471-7
		CHEMBL311857	112191	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells	ChEMBL	502	9	1	8	2.8	CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2[S+]1[O-]	10.1016/s0960-894x(02)00471-7
		44391078	69659	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL178451	69659	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		44390993	139187	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		CHEMBL369735	139187	0	None	-	1	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand	ChEMBL	529	12	2	5	4.1	CC(C)(Oc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1	10.1016/j.bmcl.2004.11.045
		10578880	16613	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.4	O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm0010217
		CHEMBL114036	16613	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2	ChEMBL	565	6	5	4	2.4	O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm0010217
		53472113	125636	0	None	-398	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	519	4	0	7	6.3	C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1	10.1021/jm5017413
		CHEMBL3422009	125636	0	None	-398	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis	ChEMBL	519	4	0	7	6.3	C[C@@H]1c2nnc(-c3csc(-c4ccc(F)cc4F)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1	10.1021/jm5017413
		10578880	16613	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	565	6	5	4	2.4	O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		CHEMBL114036	16613	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments	ChEMBL	565	6	5	4	2.4	O=C1CC(Cc2ccccc2)C(=O)NCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1	10.1021/jm011127h
		44282001	106584	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	705	12	1	7	7.0	CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL285422	106584	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	705	12	1	7	7.0	CO/N=C(\CN(C)C(=O)c1cc(OC)c(Br)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281571	117166	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	718	10	2	5	8.7	CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32430	117166	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	718	10	2	5	8.7	CO/N=C(\CN(C)C(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44281776	121029	0	None	3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	568	11	1	5	7.3	CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL33302	121029	0	None	3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	568	11	1	5	7.3	CO/N=C(\COCc1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		44337202	14747	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	700	7	1	4	7.3	O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		CHEMBL109053	14747	0	None	5	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.	ChEMBL	700	7	1	4	7.3	O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@H](c2ccc(Cl)c(Cl)c2)C1	10.1016/s0960-894x(02)00645-5
		53317584	65264	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	640	13	2	6	5.4	COc1cc2ccccc2cc1C(=O)NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1	10.1016/j.bmcl.2011.01.074
		CHEMBL1683153	65264	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins	ChEMBL	640	13	2	6	5.4	COc1cc2ccccc2cc1C(=O)NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1	10.1016/j.bmcl.2011.01.074
		118724121	123188	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	911	27	10	15	-0.5	CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)Nc1ccc([N+](=O)[O-])c2nonc12)C(C)C)C(N)=O	10.1021/jm401823z
		CHEMBL3360200	123188	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells	ChEMBL	911	27	10	15	-0.5	CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)Nc1ccc([N+](=O)[O-])c2nonc12)C(C)C)C(N)=O	10.1021/jm401823z
		44380249	127122	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	706	12	1	6	7.3	CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL353027	127122	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	706	12	1	6	7.3	CN(C/C(=N\OCc1c[nH]cn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		23626253	175527	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	566	14	6	7	2.1	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CO)CO)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL437164	175527	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	566	14	6	7	2.1	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CO)CO)CCCC1)c1cc2ccccc2s1	10.1021/jm070289w
		44380082	64889	0	None	-12	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	683	13	1	6	6.7	CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		CHEMBL167606	64889	0	None	-12	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand	ChEMBL	683	13	1	6	6.7	CN(C/C(=N\OCCCN)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1	10.1016/s0960-894x(02)00027-6
		20906619	67442	7	None	-31	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	396	4	1	4	3.7	COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1	10.1016/j.bmcl.2011.02.033
		CHEMBL1760338	67442	7	None	-31	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor	ChEMBL	396	4	1	4	3.7	COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1	10.1016/j.bmcl.2011.02.033
		9957749	187473	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	430	6	1	4	4.6	CC(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12	10.1021/jm000501v
		CHEMBL47555	187473	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	430	6	1	4	4.6	CC(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12	10.1021/jm000501v
		44266493	174187	0	None	-53	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	426	8	2	4	5.2	CC[C@@H](NC(=O)c1c(OCCO)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		CHEMBL429615	174187	0	None	-53	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB	ChEMBL	426	8	2	4	5.2	CC[C@@H](NC(=O)c1c(OCCO)c(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm980633c
		44329001	214824	0	None	-	1	Golden hamster	6.1	pKi	=	6.1	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	398	4	1	7	3.7	COC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1	10.1016/0960-894X(95)00502-K
		CHEMBL97520	214824	0	None	-	1	Golden hamster	6.1	pKi	=	6.1	Binding	Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)	ChEMBL	398	4	1	7	3.7	COC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1	10.1016/0960-894X(95)00502-K
		5764	10270	46	None	-58	2	Human	5.1	pKi	=	5.1	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		6604858	10270	46	None	-58	2	Human	5.1	pKi	=	5.1	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		CHEMBL9843	10270	46	None	-58	2	Human	5.1	pKi	=	5.1	Binding	Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1	10.1021/jm9602423
		6604014	214627	7	None	-28	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm960818o
		CHEMBL9643	214627	7	None	-28	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.	ChEMBL	396	5	1	4	4.5	COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1	10.1021/jm960818o
		2110	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/j.bmcl.2011.02.033
		219077	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/j.bmcl.2011.02.033
		3480	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/j.bmcl.2011.02.033
		CHEMBL346178	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/j.bmcl.2011.02.033
		DB04872	9743	38	None	-138	6	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay	ChEMBL	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	10.1016/j.bmcl.2011.02.033
		CHEMBL386783	219170	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand	ChEMBL		None	None	None		CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)Nc1ccc([N+](=O)[O-])c2nonc12)C(N)=O	10.1021/jm00039a012
		392622	63086	95	None	2	4	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	nan
		CHEMBL163	63086	95	None	2	4	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	nan
		11273015	65039	0	None	-14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor	ChEMBL	563	8	1	3	6.0	CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmcl.2010.12.135
		CHEMBL1682624	65039	0	None	-14	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]NKA from human cloned NK2 receptorDisplacement of [125I]NKA from human cloned NK2 receptor	ChEMBL	563	8	1	3	6.0	CC(=O)NC1(c2ccccc2)CCN(C[C@@H]2C[C@@]2(C(=O)N(C)Cc2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/j.bmcl.2010.12.135
		28417	46813	49	None	-1	12	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	46813	49	None	-1	12	Human	5.1	pKi	=	5.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		2600	10551	74	None	-6	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	10551	74	None	-6	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	10551	74	None	-6	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	10551	74	None	-6	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	10551	74	None	-6	13	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		44281567	115997	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	554	11	1	5	7.0	CO/N=C(\COCc1ccc(C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32173	115997	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	554	11	1	5	7.0	CO/N=C(\COCc1ccc(C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		10032693	116539	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	703	10	1	5	8.3	CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		CHEMBL32309	116539	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor	ChEMBL	703	10	1	5	8.3	CO/N=C(\CN(C)C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00709-0
		23625635	99595	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	647	11	4	5	3.3	O=C(Nc1ccc(I)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		CHEMBL243725	99595	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	647	11	4	5	3.3	O=C(Nc1ccc(I)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		9828448	108019	0	None	50	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	458	7	1	4	5.2	CC(C)C(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12	10.1021/jm000501v
		CHEMBL296122	108019	0	None	50	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes	ChEMBL	458	7	1	4	5.2	CC(C)C(C)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12	10.1021/jm000501v
		22405762	169932	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	474	9	0	3	5.9	CCC(=O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL417940	169932	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	474	9	0	3	5.9	CCC(=O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		23625787	156141	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	532	12	3	5	2.7	O=C(/C=C/c1ccccc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		CHEMBL394531	156141	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	532	12	3	5	2.7	O=C(/C=C/c1ccccc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1	10.1021/jm070289w
		9939040	11782	7	None	-2	4	Human	8.0	pKi	=	8.0	Binding	In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
		CHEMBL105060	11782	7	None	-2	4	Human	8.0	pKi	=	8.0	Binding	In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2	ChEMBL	623	7	2	3	6.1	CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1	10.1021/jm030786m
		22405734	206796	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	460	9	0	2	6.8	CCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		CHEMBL59542	206796	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells	ChEMBL	460	9	0	2	6.8	CCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	10.1016/s0960-894x(98)00037-7
		2726	7706	68	None	-125	72	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	7706	68	None	-125	72	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	7706	68	None	-125	72	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	7706	68	None	-125	72	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	7706	68	None	-125	72	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		44363435	43962	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	785	14	0	5	9.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		CHEMBL145314	43962	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor	ChEMBL	785	14	0	5	9.9	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(Cc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00702-2
		23625474	159966	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	551	12	3	7	2.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc([N+](=O)[O-])cc1	10.1021/jm070289w
		CHEMBL397704	159966	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	551	12	3	7	2.2	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc([N+](=O)[O-])cc1	10.1021/jm070289w
		53232	195404	95	None	1	2	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	nan
		CHEMBL503	195404	95	None	1	2	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	nan
		104974	10248	31	None	-7	7	Rat	6.0	pKi	=	6.0	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		2111	10248	31	None	-7	7	Rat	6.0	pKi	=	6.0	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		3481	10248	31	None	-7	7	Rat	6.0	pKi	=	6.0	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		CHEMBL308148	10248	31	None	-7	7	Rat	6.0	pKi	=	6.0	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		DB06660	10248	31	None	-7	7	Rat	6.0	pKi	=	6.0	Binding	The compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranesThe compound was evaluated for the inhibition of [125I]NKA binding to Tachykinin receptor 2 from rat duodenum membranes	ChEMBL	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	10.1016/S0960-894X(00)80694-0
		44314486	112433	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	739	13	0	7	6.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL312528	112433	0	None	-6	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	739	13	0	7	6.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(N(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		23625322	99084	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	534	11	3	6	2.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC1)c1cc2ccccc2s1	10.1021/jm070289w
		CHEMBL242848	99084	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor	ChEMBL	534	11	3	6	2.7	O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC1)c1cc2ccccc2s1	10.1021/jm070289w
		44392318	129321	0	None	-38018	2	Human	5.0	pKi	=	5.0	Binding	Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor	ChEMBL	519	7	0	4	5.0	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1	10.1016/j.bmcl.2005.05.134
		CHEMBL360134	129321	0	None	-38018	2	Human	5.0	pKi	=	5.0	Binding	Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor	ChEMBL	519	7	0	4	5.0	O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1	10.1016/j.bmcl.2005.05.134
		44550460	203816	0	None	-69	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	537	8	0	3	5.9	CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm900948q
		CHEMBL567198	203816	0	None	-69	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells	ChEMBL	537	8	0	3	5.9	CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccccc2Cl)c2ccc(Cl)c(Cl)c2)CC1	10.1021/jm900948q
		44314547	109652	0	None	-5	2	Human	6.0	pKi	=	6.0	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	661	11	0	5	8.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		CHEMBL305826	109652	0	None	-5	2	Human	6.0	pKi	=	6.0	Binding	Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2	ChEMBL	661	11	0	5	8.5	CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(00)00464-9
		64143	205643	62	None	-1	8	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		CHEMBL584	205643	62	None	-1	8	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		2247	7293	81	None	-44	42	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	7293	81	None	-44	42	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	7293	81	None	-44	42	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	7293	81	None	-44	42	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	7293	81	None	-44	42	Human	6.0	pKi	=	6	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		71549635	167653	0	None	-1412	3	Human	5.0	pKi	=	5	Binding	Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	450	4	0	8	4.4	C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1	nan
		CHEMBL4115030	167653	0	None	-1412	3	Human	5.0	pKi	=	5	Binding	Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).	ChEMBL	450	4	0	8	4.4	C[C@@H]1c2nnc(-c3csc(N(C)C)n3)n2CCN1C(=O)c1ccc(-c2cccs2)cc1	nan
		2112	7391	0	None	-	1	Human	6.0	pKd	=	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		2115	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7562907
		2115	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7682062
		2115	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7713168
		9953599	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7562907
		9953599	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7682062
		9953599	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7713168
		CHEMBL2110370	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7562907
		CHEMBL2110370	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7682062
		CHEMBL2110370	8628	19	None	-8	3	Human	8.7	pKd	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	414	7	1	3	4.1	COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1	7713168
		2089	9542	28	None	102	5	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10455255
		3795	9542	28	None	102	5	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10455255
		5311311	9542	28	None	102	5	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10455255
		CHEMBL217406	9542	28	None	102	5	Human	9.3	pKd	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10455255
		104974	10248	31	None	-7	7	Rat	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7719707
		2111	10248	31	None	-7	7	Rat	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7719707
		3481	10248	31	None	-7	7	Rat	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7719707
		CHEMBL308148	10248	31	None	-7	7	Rat	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7719707
		DB06660	10248	31	None	-7	7	Rat	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7719707
		9850582	204021	22	125I-[MePhe7]-NKB	-1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		CHEMBL56835	204021	22	125I-[MePhe7]-NKB	-1	6	Human	9.6	pKi	=	9.6	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		9850582	204021	22	3H-NEUROKININ A	-1	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		CHEMBL56835	204021	22	3H-NEUROKININ A	-1	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		9850582	204021	22	125I-Iodohistidyl	-1	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		CHEMBL56835	204021	22	125I-Iodohistidyl	-1	6	Human	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		None	222852	0	125I-Iodohistidyl	-1	6	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	1133	37	16	17	-4.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N	None
		None	222852	0	125I-Iodohistidyl	-1	6	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	1133	37	16	17	-4.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N	None
		9850582	204021	22	125I-Iodohistidyl	1	6	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		CHEMBL56835	204021	22	125I-Iodohistidyl	1	6	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		None	222852	0	125I-[MePhe7]-NKB	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	1133	37	16	17	-4.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N	None
		None	222852	0	125I-Iodohistidyl	1	6	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	1133	37	16	17	-4.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N	None
		None	222852	0	125I-Iodohistidyl	-1	6	Bovine	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	1133	37	16	17	-4.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N	None
		None	222852	0	125I-Iodohistidyl	-1	6	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	1133	37	16	17	-4.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N	None
		None	222854	0	125I-Iodohistidyl-NKA	-95	8	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	605	8	0	3	7.4	CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5	None
		202	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		5656	209845	87	UNDEFINED	-7	43	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	UNDEFINED	-7	43	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		54841	209906	52	UNDEFINED	-1	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	209906	52	UNDEFINED	-1	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		3075702	224111	0	125I-NKA	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
		119376	8622	48	3H-NEUROKININ A	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		247	8622	48	3H-NEUROKININ A	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		CHEMBL33884	8622	48	3H-NEUROKININ A	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		3294	8787	111	125I-NKA	-14454	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	125I-NKA	-14454	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	125I-NKA	-14454	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	125I-NKA	-14454	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	125I-NKA	-14454	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		243	9976	91	3H-SR 48968	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	9976	91	3H-SR 48968	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	9976	91	3H-SR 48968	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	9976	91	3H-SR 48968	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	9976	91	3H-SR 48968	-1096	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		21830793	98610	10	3H-8-OH-DPAT	-66069	46	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	98610	10	3H-8-OH-DPAT	-66069	46	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		44208932	147485	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		CHEMBL381689	147485	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		5079497	222853	0	125I-[MePhe7]-NKB	-1445	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	841	26	8	10	-0.0	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)N(C)C(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)CCC(=O)O	None
		None	222907	0	125I-Neurokinin A	-1	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	164	3	1	3	0.8	C1CNC1COC2=CN=CC=C2	None
		119380	222908	0	125I-Neurokinin A	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	166	1	0	3	1.8	CC1=NOC(=C1)C2CCCN2C	None
		None	223272	0	125I-NKA	-10471285	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	372	2	1	3	4.4	CC(C)(C)C1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=C(C=CC=N3)Cl	None
		2098	10466	36	125I-[MePhe7]-NKB	-457	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
		36511	10466	36	125I-[MePhe7]-NKB	-457	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
		3805	10466	36	125I-[MePhe7]-NKB	-457	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
		3835	10466	36	125I-[MePhe7]-NKB	-457	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
		CHEMBL235363	10466	36	125I-[MePhe7]-NKB	-457	6	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase		None	None	None		None	None
		133090	105199	20	125I-NKA	-9	3	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	382	5	2	3	5.5	CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1	None
		133090	105199	20	125I-[MePhe7]-NKB	-9	3	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	382	5	2	3	5.5	CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1	None
		CHEMBL275544	105199	20	125I-NKA	-9	3	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	382	5	2	3	5.5	CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1	None
		CHEMBL275544	105199	20	125I-[MePhe7]-NKB	-9	3	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	382	5	2	3	5.5	CCC(NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1	None
		None	222966	0	125I-Iodohistidyl	-1023	5	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	588	8	2	5	4.3	CN1C=C(C2=CC=CC=C21)C(=O)N3CC(CC3C(=O)NC(CC4=CC5=CC=CC=C5C=C4)C(=O)N(C)CC6=CC=CC=C6)O	None
		None	222851	0	125I-[MePhe7]-NKB	-20	4	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	1210	38	14	16	-1.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N	None
		None	222852	0	125I-Iodohistidyl	-3	6	Guinea pig	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	1133	37	16	17	-4.6	CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)O)NC(=O)C(CCCCN)NC(=O)C(CC2=CN=CN2)N	None
		None	222854	0	3H-NEUROKININ A	-54	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	605	8	0	3	7.4	CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5	None
		None	222854	0	125I-Iodohistidyl-NKA	-54	8	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	605	8	0	3	7.4	CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5	None
		None	222854	0	125I-Iodohistidyl-NKA	-95	8	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	605	8	0	3	7.4	CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5	None
		None	222967	0	125I-Iodohistidyl	-3	6	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	1041	17	10	13	0.9	CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C	None
		None	222854	0	125I-NEUROPEPTIDE Y	-95	8	Guinea pig	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	605	8	0	3	7.4	CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5	None
		None	222967	0	125I-Iodohistidyl	-12	6	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	1041	17	10	13	0.9	CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C	None
		None	222854	0	125I-[MePhe7]-NKB	-54	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	605	8	0	3	7.4	CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5	None
		None	222854	0	125I-NKA	-54	8	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	605	8	0	3	7.4	CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5	None
		None	222967	0	125I-Iodohistidyl	-12	6	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	1041	17	10	13	0.9	CCCCCC1=CC=CC=C1CCC(=O)NC2C(OC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(=CC3=CC=C(C=C3)O)N(C2=O)C)CC(C)C)CC4=CC=CC=C4)C(C)O)CC(=O)N)CO)C	None
		64143	205643	62	None	-1	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	None
		CHEMBL584	205643	62	None	-1	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	None
		53232	195404	95	None	1	2	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None
		CHEMBL503	195404	95	None	1	2	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	404	6	1	5	4.2	CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	None
		2726	7706	68	None	-125	72	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	None	-125	72	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	None	-125	72	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	None	-125	72	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	None	-125	72	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		28417	46813	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		CHEMBL1479	46813	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		1212	8443	50	None	-389	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	None	-389	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	None	-389	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	None	-389	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	None	-389	65	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		176	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2157	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2566	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		CHEMBL633	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		DB01118	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		3823	56995	42	None	-36	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		76973198	56995	42	None	-36	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL157101	56995	42	None	-36	11	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	530	7	0	7	4.2	CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		2812	11551	101	None	-28	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	11551	101	None	-28	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		448537	167029	89	None	-26	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		CHEMBL411	167029	89	None	-26	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		657255	205863	34	None	-17	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		CHEMBL588119	205863	34	None	-17	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	337	12	2	3	5.6	CCCCCCCCN[C@H](C)[C@@H](O)c1ccc(SC(C)C)cc1	None
		441243	16608	58	None	-19	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	None
		CHEMBL114	16608	58	None	-19	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	670	12	5	7	3.1	CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	None
		138106885	173690	75	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	None
		36314	173690	75	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	None
		CHEMBL428647	173690	75	None	-1	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	None
		3198	212292	76	None	-21	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1201049	212292	76	None	-21	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL808	212292	76	None	-21	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		5362440	16793	63	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	613	11	4	7	2.9	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O	None
		CHEMBL115	16793	63	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	613	11	4	7	2.9	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O	None
		5318	22348	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1200348	22348	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1221	22348	49	None	-1	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	396	6	0	3	6.5	Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		4189	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1559	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL91	213701	96	None	-18	34	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		2406	107180	89	None	-16	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
		CHEMBL290106	107180	89	None	-16	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	None
		1548955	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		2800	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		CHEMBL2355051	95356	20	None	-1	18	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	None
		1024	8072	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central		None	None	None		None	None
		162639143	8072	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central		None	None	None		None	None
		5284373	8072	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central		None	None	None		None	None
		760	8072	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central		None	None	None		None	None
		CHEMBL160	8072	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central		None	None	None		None	None
		DB00091	8072	71	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central		None	None	None		None	None
		3598	194600	76	None	-1	7	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
		CHEMBL496	194600	76	None	-1	7	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	None
		133	9274	52	None	-165	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	None	-165	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	None	-165	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	None	-165	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	None	-165	43	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2351	10059	64	None	-13	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		2820	10059	64	None	-13	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		5035	10059	64	None	-13	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		CHEMBL81	10059	64	None	-13	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		DB00481	10059	64	None	-13	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		1836	9370	59	None	-40	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		3340	9370	59	None	-40	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		5281040	9370	59	None	-40	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		CHEMBL787	9370	59	None	-40	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		DB00471	9370	59	None	-40	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	585	12	2	4	8.9	OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1	None
		1016	10519	78	None	-16	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2561	10519	78	None	-16	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2733526	10519	78	None	-16	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5384	10519	78	None	-16	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		CHEMBL83	10519	78	None	-16	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		DB00675	10519	78	None	-16	35	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5353853	24758	47	None	-14	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		9556529	24758	47	None	-14	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1262	24758	47	None	-14	15	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		2247	7293	81	None	-44	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	7293	81	None	-44	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	7293	81	None	-44	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	7293	81	None	-44	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	7293	81	None	-44	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2600	10551	74	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	10551	74	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	10551	74	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	10551	74	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	10551	74	None	-6	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		392622	63086	95	None	2	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	None
		CHEMBL163	63086	95	None	2	4	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	720	17	4	9	5.9	CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1	None
		2335	18620	22	None	-3	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		8478	18620	22	None	-3	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL1182210	18620	22	None	-3	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		CHEMBL221753	18620	22	None	-3	12	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	None
		3191	109635	97	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	109635	97	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		11057	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		3468	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL459265	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL64894	182928	23	None	-1	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		138106918	202265	42	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	None
		5311497	202265	42	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	None
		CHEMBL553025	202265	42	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	778	7	2	11	4.8	CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2	None
		148124	213878	86	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	None
		CHEMBL3545252	213878	86	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	None
		CHEMBL92	213878	86	None	-	1	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	807	8	5	14	3.3	CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C	None
		3561	25849	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		CHEMBL1289	25849	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		9850582	204021	22	125I-Iodohistidyl	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		CHEMBL56835	204021	22	125I-Iodohistidyl	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	551	9	1	3	6.4	CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1	None
		None	222854	0	125I-NEUROPEPTIDE Y	-95	8	Guinea pig	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	605	8	0	3	7.4	CC(=O)N(C)C1(CCN(CC1)CCCC2(CCCN(C2)C(=O)C3=CC=CC=C3)C4=CC(=C(C=C4)Cl)Cl)C5=CC=CC=C5	None
		1973	210262	15	125I-NKA	-3	36	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL1394464	210262	15	125I-NKA	-3	36	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL66089	210262	15	125I-NKA	-3	36	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		5771	10921	0	None	-17	2	Human	3.8	pKi	=	3.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	5	2	8	2.7	O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C	7562491
		9847605	10921	0	None	-17	2	Human	3.8	pKi	=	3.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	5	2	8	2.7	O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C	7562491
		5771	10921	0	None	17	2	Guinea pig	5.1	pKi	=	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	5	2	8	2.7	O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C	7562491
		9847605	10921	0	None	17	2	Guinea pig	5.1	pKi	=	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	471	5	2	8	2.7	O/N=C(/C(=O)N1CCN(CC1)c1nc(Nc2ccc(cc2)Cl)c2c(n1)C(=O)N(C2)C(C)C)\C	7562491
		107967	8427	0	None	-1000	2	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	588	8	2	5	4.3	O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2	11937780
		2114	8427	0	None	-1000	2	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	588	8	2	5	4.3	O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2	11937780
		CHEMBL1416993	8427	0	None	-1000	2	Human	6.1	pKi	=	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	588	8	2	5	4.3	O[C@@H]1C[C@H](N(C1)C(=O)c1cn(c2c1cccc2)C)C(=O)N[C@H](C(=O)N(Cc1ccccc1)C)Cc1ccc2c(c1)cccc2	11937780
		2087	8701	0	None	-28183	4	Human	6.3	pKi	=	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		164286	10045	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		2118	10045	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		10327625	10896	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	607	9	0	2	8.3	CC(Oc1cccc(c1)CC(=O)N1CCCC(C1)(CC[N+]1(C)CCC(CC1)c1ccccc1)c1ccc(c(c1)Cl)Cl)C	11937780
		2122	10896	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	607	9	0	2	8.3	CC(Oc1cccc(c1)CC(=O)N1CCCC(C1)(CC[N+]1(C)CCC(CC1)c1ccccc1)c1ccc(c(c1)Cl)Cl)C	11937780
		2132	10516	58	None	-97	6	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	9190866
		5311424	10516	58	None	-97	6	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	9190866
		CHEMBL10188	10516	58	None	-97	6	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	5	2	3	5.5	CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1	9190866
		2110	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	12206858
		2110	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	9190866
		219077	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	12206858
		219077	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	9190866
		3480	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	12206858
		3480	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	9190866
		CHEMBL346178	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	12206858
		CHEMBL346178	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	9190866
		DB04872	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	12206858
		DB04872	9743	38	None	-138	6	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	605	8	0	3	7.4	O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1	9190866
		124003	9264	22	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		2116	9264	22	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		CHEMBL507824	9264	22	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		2089	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11137709
		2089	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		2089	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		2089	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		3795	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11137709
		3795	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		3795	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		3795	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		5311311	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11137709
		5311311	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		5311311	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		5311311	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		CHEMBL217406	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11137709
		CHEMBL217406	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		CHEMBL217406	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		CHEMBL217406	9542	28	None	102	5	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		2123	9540	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16979621
		2123	9540	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9484857
		3086682	9540	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	16979621
		3086682	9540	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9484857
		2120	10893	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	639	10	1	6	5.9	COc1cc(cc(c1OC)OC)C(=O)N(CC(c1ccc(c(c1)Cl)Cl)CCN1CCC2(CC1)NC(=O)Cc1c2cccc1)C	11937780
		9852373	10893	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	639	10	1	6	5.9	COc1cc(cc(c1OC)OC)C(=O)N(CC(c1ccc(c(c1)Cl)Cl)CCN1CCC2(CC1)NC(=O)Cc1c2cccc1)C	11937780
		5778	10922	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	516	8	1	3	5.1	O=C1NCCCN1C1CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C	22149761
		9871234	10922	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	516	8	1	3	5.1	O=C1NCCCN1C1CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C	22149761
		5769	10297	5	None	194	2	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	6	1	4	6.5	O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C	11356103
		9806459	10297	5	None	194	2	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	6	1	4	6.5	O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C	11356103
		CHEMBL295770	10297	5	None	194	2	Human	9.0	pKi	=	9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	6	1	4	6.5	O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C	11356103
		3901	9265	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11063600
		5311274	9265	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11063600
		104974	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1313515
		2111	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1313515
		3481	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1313515
		CHEMBL308148	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1313515
		DB06660	10248	31	None	-7	7	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	1313515
		104974	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	12206858
		104974	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7682062
		104974	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	9190866
		2111	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	12206858
		2111	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7682062
		2111	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	9190866
		3481	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	12206858
		3481	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7682062
		3481	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	9190866
		CHEMBL308148	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	12206858
		CHEMBL308148	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7682062
		CHEMBL308148	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	9190866
		DB06660	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	12206858
		DB06660	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	7682062
		DB06660	10248	31	None	1	7	Human	9.6	pKi	=	9.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	551	9	1	3	6.4	CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1	9190866
		3882	8638	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8027981
		6324620	8638	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	8027981
		10483085	10894	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	567	7	1	3	6.0	O=C1Cc2ccccc2C2(N1)CCN(CC2)CCC(c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccc(cc1)F)C	11937780
		2121	10894	0	None	-	1	Human	9.9	pKi	=	9.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	567	7	1	3	6.0	O=C1Cc2ccccc2C2(N1)CCN(CC2)CCC(c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccc(cc1)F)C	11937780
		11527495	8749	19	None	-	1	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	644	11	3	6	5.2	O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1	16979621
		2117	8749	19	None	-	1	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	644	11	3	6	5.2	O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1	16979621
		CHEMBL266125	8749	19	None	-	1	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	644	11	3	6	5.2	O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1	16979621
		DB12042	8749	19	None	-	1	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	644	11	3	6	5.2	O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1	16979621
		2090	9543	25	None	-38	4	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		2090	9543	25	None	-38	4	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		5311312	9543	25	None	-38	4	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		5311312	9543	25	None	-38	4	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		CHEMBL437797	9543	25	None	-38	4	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		CHEMBL437797	9543	25	None	-38	4	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		2098	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		2098	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		2098	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		36511	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		36511	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		36511	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		3805	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		3805	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		3805	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		3835	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		3835	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		3835	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		CHEMBL235363	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11786503
		CHEMBL235363	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	7682062
		CHEMBL235363	10466	36	None	-457	6	Human	6.4	pKi	None	6.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		2113	9868	0	None	-199	3	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9190866
		2106	10319	4	None	-1	3	Human	9.4	pKi	None	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	711	12	1	6	6.4	CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C	12206858
		9875034	10319	4	None	-1	3	Human	9.4	pKi	None	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	711	12	1	6	6.4	CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C	12206858
		CHEMBL77023	10319	4	None	-1	3	Human	9.4	pKi	None	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	711	12	1	6	6.4	CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C	12206858

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Ligand source activities (1 row/activity)