Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

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 DOI
25174150 9119 None 0 Human Functional pIC50 = 10.2 10.2 64 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099326 9119 None 0 Human Functional pIC50 = 10.2 10.2 64 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
25191879 9128 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 599 18 2 5 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099335 9128 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 599 18 2 5 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3cccc(F)c3)c2)c1CCC(=O)O 10.1021/jm1001919
25191880 9125 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 587 18 2 6 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099332 9125 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 587 18 2 6 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192021 9116 None 0 Human Functional pIC50 = 9.7 9.7 223 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099323 9116 None 0 Human Functional pIC50 = 9.7 9.7 223 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192023 8533 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 625 18 2 7 7.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094346 8533 None 0 Human Functional pIC50 = 9.7 9.7 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 625 18 2 7 7.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192174 9124 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 586 18 2 5 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099331 9124 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 586 18 2 5 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
132379 111795 None 16 Human Functional pIC50 = 9.4 9.4 - 1
Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111795 None 16 Human Functional pIC50 = 9.4 9.4 - 1
Antagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membraneAntagonistic activity against LTB4 receptor using guinea pig (GP) spleen cell membrane
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
25192176 8534 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 626 18 2 8 7.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094347 8534 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 626 18 2 8 7.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192175 9127 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 588 18 2 7 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099334 9127 None 0 Human Functional pIC50 = 9.4 9.4 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 588 18 2 7 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cncnc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192022 3355 None 7 Human Functional pIC50 = 9.4 9.4 21 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6158 3355 None 7 Human Functional pIC50 = 9.4 9.4 21 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
CHEMBL1098560 3355 None 7 Human Functional pIC50 = 9.4 9.4 21 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
23501721 9123 None 0 Human Functional pIC50 = 9.3 9.3 316 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099330 9123 None 0 Human Functional pIC50 = 9.3 9.3 316 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
25192325 9126 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 621 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099333 9126 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 621 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccnc(Cl)c3)c2)c1CCC(=O)O 10.1021/jm1001919
25192326 9032 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 592 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1098550 9032 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 592 18 2 6 8.6 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccsc3)cc(-c3ccsc3)c2)c1CCC(=O)O 10.1021/jm1001919
25192327 9130 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 624 18 2 6 8.2 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099337 9130 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 624 18 2 6 8.2 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
25192468 8536 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094349 8536 None 0 Human Functional pIC50 = 9.2 9.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccccc3F)c2)c1CCC(=O)O 10.1021/jm1001919
132379 111795 None 16 Human Functional pIC50 = 9.1 9.1 - 1
Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111795 None 16 Human Functional pIC50 = 9.1 9.1 - 1
Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.Concentration inhibiting 1 nM LTB4-induced aggregation in GP polymorphonuclear (PMN) leukocytes.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
25192471 8535 None 0 Human Functional pIC50 = 8.9 8.9 15 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094348 8535 None 0 Human Functional pIC50 = 8.9 8.9 15 2
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
10319829 26126 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 26126 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10341135 29396 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 29396 None 0 Human Functional pIC50 = 7 7.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10047140 27615 None 0 Human Functional pIC50 = 6 6.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 27615 None 0 Human Functional pIC50 = 6 6.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
14946858 29169 None 0 Human Functional pIC50 = 6 6.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 29169 None 0 Human Functional pIC50 = 6 6.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
6444688 187426 None 30 Human Functional pIC50 = 6 6.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 187426 None 30 Human Functional pIC50 = 6 6.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
10071290 28108 None 0 Human Functional pIC50 = 5 5.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 28108 None 0 Human Functional pIC50 = 5 5.0 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
25192022 3355 None 7 Human Functional pIC50 = 6.9 6.9 21 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6158 3355 None 7 Human Functional pIC50 = 6.9 6.9 21 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
CHEMBL1098560 3355 None 7 Human Functional pIC50 = 6.9 6.9 21 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 10.1021/jm1001919
6444688 187426 None 30 Human Functional pIC50 = 7.9 7.9 - 1
Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity against human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00100a034
CHEMBL49302 187426 None 30 Human Functional pIC50 = 7.9 7.9 - 1
Antagonistic activity against human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity against human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00100a034
10343923 27791 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 27791 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10477988 28151 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 28151 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10364772 28168 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 28168 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
25192471 8535 None 0 Human Functional pIC50 = 6.9 6.9 15 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094348 8535 None 0 Human Functional pIC50 = 6.9 6.9 15 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 642 18 2 6 8.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
6444688 187426 None 30 Human Functional pIC50 = 7.9 7.9 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm960088k
CHEMBL49302 187426 None 30 Human Functional pIC50 = 7.9 7.9 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm960088k
46888200 9129 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 637 18 3 4 9.1 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4[nH]ccc4c3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099336 9129 None 0 Human Functional pIC50 = 7.9 7.9 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 637 18 3 4 9.1 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3cccc(F)c3)cc(-c3ccc4[nH]ccc4c3)c2)c1CCC(=O)O 10.1021/jm1001919
10341242 28161 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 28161 None 0 Human Functional pIC50 = 5.9 5.9 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
6450158 187280 None 20 Human Functional pIC50 = 6.9 6.9 - 1
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 187280 None 20 Human Functional pIC50 = 6.9 6.9 - 1
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
46888199 9122 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 696 18 2 8 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCCO4)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099329 9122 None 0 Human Functional pIC50 = 6.9 6.9 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 696 18 2 8 8.0 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCCO4)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
114999 3538 None 17 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
6156 3538 None 17 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
CHEMBL14823 3538 None 17 Human Functional pIC50 = 6.9 6.9 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
44382384 59561 None 0 Human Functional pIC50 = 4.9 4.9 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL171666 59561 None 0 Human Functional pIC50 = 4.9 4.9 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10092630 27829 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 27829 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10475503 28016 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 28016 None 0 Human Functional pIC50 = 7.8 7.8 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10023244 26170 None 1 Human Functional pIC50 = 6.8 6.8 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 26170 None 1 Human Functional pIC50 = 6.8 6.8 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357534 26748 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 26748 None 0 Human Functional pIC50 = 6.7 6.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10406292 28404 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 28404 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9865985 28681 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 28681 None 0 Human Functional pIC50 = 5.7 5.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
10427789 27948 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 27948 None 0 Human Functional pIC50 = 4.7 4.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
23501721 9123 None 0 Human Functional pIC50 = 6.7 6.7 316 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099330 9123 None 0 Human Functional pIC50 = 6.7 6.7 316 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 581 18 2 5 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)n2)c1CCC(=O)O 10.1021/jm1001919
9976757 28509 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 28509 None 0 Human Functional pIC50 = 7.7 7.7 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44382378 58886 None 0 Human Functional pIC50 = 6.7 6.7 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL168854 58886 None 0 Human Functional pIC50 = 6.7 6.7 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10474602 25987 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 25987 None 0 Human Functional pIC50 = 5.6 5.6 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
46888201 9131 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 654 19 2 7 8.2 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)cc1 10.1021/jm1001919
CHEMBL1099338 9131 None 0 Human Functional pIC50 = 8.5 8.5 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 654 19 2 7 8.2 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc4c(c3)OCO4)c2)cc1 10.1021/jm1001919
3368 1173 None 29 Mouse Functional pIC50 = 7.5 7.5 -3 2
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 1173 None 29 Mouse Functional pIC50 = 7.5 7.5 -3 2
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 1173 None 29 Mouse Functional pIC50 = 7.5 7.5 -3 2
Tested for antagonistic activity in mouse spleen membrane against LTB4 receptorTested for antagonistic activity in mouse spleen membrane against LTB4 receptor
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
10001576 28389 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 28389 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10046878 28441 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 28441 None 0 Human Functional pIC50 = 5.5 5.5 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
46888196 9118 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 640 20 2 6 8.5 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc(OC)cc3)c2)cc1 10.1021/jm1001919
CHEMBL1099325 9118 None 0 Human Functional pIC50 = 7.5 7.5 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 640 20 2 6 8.5 COc1ccc(-c2cc(OCCCCCCc3cccc(OCCCC(=O)O)c3CCC(=O)O)cc(-c3ccc(OC)cc3)c2)cc1 10.1021/jm1001919
44382275 59757 None 0 Human Functional pIC50 = 5.5 5.5 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL172457 59757 None 0 Human Functional pIC50 = 5.5 5.5 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
25192021 9116 None 0 Human Functional pIC50 = 7.4 7.4 223 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099323 9116 None 0 Human Functional pIC50 = 7.4 7.4 223 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 580 18 2 4 8.5 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3ccccc3)c2)c1CCC(=O)O 10.1021/jm1001919
44382276 120380 None 0 Human Functional pIC50 = 4.4 4.4 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL352814 120380 None 0 Human Functional pIC50 = 4.4 4.4 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
9978895 119040 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL342416 119040 None 0 Human Functional pIC50 = 7.4 7.4 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10021742 9458 None 6 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationAntagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilization
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 9458 None 6 Human Functional pIC50 = 5.3 5.3 - 1
Antagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilizationAntagonist activity at LTB4 receptor in fura-2 loaded human U937 cells assessed as inhibition of LTB4-induced calcium mobilization
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
44356239 27850 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonistic activity in human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity in human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 361 8 0 2 4.9 CN(CCc1ccccc1)C(=O)CC1=CC=C(OCc2ccccc2)CC1 10.1021/jm00100a034
CHEMBL137121 27850 None 0 Human Functional pIC50 = 5.3 5.3 - 1
Antagonistic activity in human polymorphonuclear (PMN) LTB4 receptorAntagonistic activity in human polymorphonuclear (PMN) LTB4 receptor
ChEMBL 361 8 0 2 4.9 CN(CCc1ccccc1)C(=O)CC1=CC=C(OCc2ccccc2)CC1 10.1021/jm00100a034
46888197 9120 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3cncnc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099327 9120 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccccc3)cc(-c3cncnc3)c2)c1CCC(=O)O 10.1021/jm1001919
46888198 9121 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 668 18 2 8 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099328 9121 None 0 Human Functional pIC50 = 8.3 8.3 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 668 18 2 8 7.9 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc4c(c3)OCO4)cc(-c3ccc4c(c3)OCO4)c2)c1CCC(=O)O 10.1021/jm1001919
9934323 100307 None 0 Human Functional pIC50 = 6.3 6.3 - 1
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL288758 100307 None 0 Human Functional pIC50 = 6.3 6.3 - 1
The antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophilsThe antagonist activity measured as inhibition of LTB4 response in aggregation of neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
10091738 27811 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 27811 None 0 Human Functional pIC50 = 6.2 6.2 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
46888202 8537 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 656 18 2 6 8.4 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1094350 8537 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 656 18 2 6 8.4 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc4c(c3)OCCO4)c2)c1CCC(=O)O 10.1021/jm1001919
44382468 59105 None 0 Human Functional pIC50 = 5.2 5.2 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL169639 59105 None 0 Human Functional pIC50 = 5.2 5.2 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisIn vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10430674 119402 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 119402 None 0 Human Functional pIC50 = 7.2 7.2 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
25174150 9119 None 0 Human Functional pIC50 = 7.2 7.2 64 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099326 9119 None 0 Human Functional pIC50 = 7.2 7.2 64 2
Antagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challengeAntagonist activity at FLAG-tagged human BLT1 receptor expressed in HEK293 cells assessed as inhibition of LTB4-stimulated calcium mobilization preincubated for 10 mins before LTB4 challenge
ChEMBL 582 18 2 6 7.3 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccncc3)cc(-c3ccncc3)c2)c1CCC(=O)O 10.1021/jm1001919
44357546 116817 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 116817 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
46888195 9117 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 616 18 2 4 8.7 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc(F)cc3)c2)c1CCC(=O)O 10.1021/jm1001919
CHEMBL1099324 9117 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Antagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 minsAntagonist activity at BLT1 receptor expressed in human HL60 cells assessed as inhibition of LTB4-stimulated calcium flux after 30 mins
ChEMBL 616 18 2 4 8.7 O=C(O)CCCOc1cccc(CCCCCCOc2cc(-c3ccc(F)cc3)cc(-c3ccc(F)cc3)c2)c1CCC(=O)O 10.1021/jm1001919
122023 50810 None 43 Human Functional pIC50 = 7.1 7.1 1 3
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
CHEMBL15766 50810 None 43 Human Functional pIC50 = 7.1 7.1 1 3
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
CHEMBL45460 50810 None 43 Human Functional pIC50 = 7.1 7.1 1 3
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm960088k
132379 111795 None 16 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111795 None 16 Human Functional pIC50 = 8.1 8.1 - 1
Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg. Antagonistic activity against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
3368 1173 None 29 Human Functional pIC50 = 8.0 8.0 3 2
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 1173 None 29 Human Functional pIC50 = 8.0 8.0 3 2
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 1173 None 29 Human Functional pIC50 = 8.0 8.0 3 2
Tested for antagonistic activity against LTB4 receptor in guinea pig spleen membraneTested for antagonistic activity against LTB4 receptor in guinea pig spleen membrane
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
10022413 27666 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 27666 None 0 Human Functional pIC50 = 6.1 6.1 - 1
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytesInhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10692884 188271 None 0 Human Functional pKi = 8.0 8.0 - 0
Leukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNsLeukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNs
ChEMBL 409 10 1 3 5.1 CCN(CC)C(=O)/C=C(\C)c1ccc(OC(C)c2ccccc2)c(CCC(=O)O)c1 10.1021/jm980540v
CHEMBL49866 188271 None 0 Human Functional pKi = 8.0 8.0 - 0
Leukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNsLeukotriene B4 receptor antagonistic activity was measured by the inhibition of LTB4 induced [Ca2+] release from human PMNs
ChEMBL 409 10 1 3 5.1 CCN(CC)C(=O)/C=C(\C)c1ccc(OC(C)c2ccccc2)c(CCC(=O)O)c1 10.1021/jm980540v
60490 209719 None 60 Human Functional pIC50 = 8.2 8.2 -8 2
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
Drug Central 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O None
CHEMBL93 209719 None 60 Human Functional pIC50 = 8.2 8.2 -8 2
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
Drug Central 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O None
71398 106495 None 32 Human Functional pIC50 = 8.2 8.2 3 14
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
Drug Central 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 None
CHEMBL313972 106495 None 32 Human Functional pIC50 = 8.2 8.2 3 14
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
Drug Central 302 5 4 4 3.6 C[C@@H](Cc1ccc(O)c(O)c1)[C@H](C)Cc1ccc(O)c(O)c1 None
6157 2934 None 20 Human Functional pIC50 = 5.8 5.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6438358 2934 None 20 Human Functional pIC50 = 5.8 5.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
CHEMBL422420 2934 None 20 Human Functional pIC50 = 5.8 5.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
114999 3538 None 17 Human Functional pIC50 = 6.1 6.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
6156 3538 None 17 Human Functional pIC50 = 6.1 6.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
CHEMBL14823 3538 None 17 Human Functional pIC50 = 6.1 6.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
3368 1173 None 29 Human Functional pIC50 = 8.1 8.1 3 2
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
9867257 1173 None 29 Human Functional pIC50 = 8.1 8.1 3 2
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
CHEMBL51770 1173 None 29 Human Functional pIC50 = 8.1 8.1 3 2
UnclassifiedUnclassified
Guide to Pharmacology 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 7714764
25192022 3355 None 7 Human Functional pIC50 = 8.1 8.1 21 2
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
6158 3355 None 7 Human Functional pIC50 = 8.1 8.1 21 2
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
CHEMBL1098560 3355 None 7 Human Functional pIC50 = 8.1 8.1 21 2
UnclassifiedUnclassified
Guide to Pharmacology 630 18 2 7 8.3 OC(=O)CCc1c(CCCCCCOc2cc(cc(c2)c2ccc3c(c2)OCO3)c2ccsc2)cccc1OCCCC(=O)O 20214997
177941 1588 None 41 Human Functional pIC50 = 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
2948 1588 None 41 Human Functional pIC50 = 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
CHEMBL329123 1588 None 41 Human Functional pIC50 = 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
DB12850 1588 None 41 Human Functional pIC50 = 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
6154 634 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
6154 634 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
9956189 634 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
9956189 634 None 0 Human Functional pIC50 = 8.5 8.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
6155 1176 None 0 Human Functional pIC50 = 8.6 8.6 1318 2
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
9823886 1176 None 0 Human Functional pIC50 = 8.6 8.6 1318 2
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
CHEMBL301829 1176 None 0 Human Functional pIC50 = 8.6 8.6 1318 2
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
DB13053 1176 None 0 Human Functional pIC50 = 8.6 8.6 1318 2
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
44379678 165017 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 527 14 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL422388 165017 None 0 Human Binding pIC50 = 10 10.0 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 527 14 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
44379453 58102 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 513 13 1 6 4.9 CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167350 58102 None 0 Human Binding pIC50 = 9.8 9.8 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 513 13 1 6 4.9 CCCc1c(OCCCOc2ccc(C(=O)N(C)C)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
15817161 58152 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 499 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167804 58152 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 499 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
9865985 28681 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 28681 None 0 Human Binding pIC50 = 9 9.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
114999 3538 None 17 Human Binding pIC50 = 9 9.0 - 1
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
6156 3538 None 17 Human Binding pIC50 = 9 9.0 - 1
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
CHEMBL14823 3538 None 17 Human Binding pIC50 = 9 9.0 - 1
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/S0960-894X(01)80853-2
204058 163554 None 7 Human Binding pIC50 = 8.9 8.9 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm960088k
CHEMBL419948 163554 None 7 Human Binding pIC50 = 8.9 8.9 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm960088k
196905 111694 None 3 Human Binding pIC50 = 8.8 8.8 - 0
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm960088k
CHEMBL328492 111694 None 3 Human Binding pIC50 = 8.8 8.8 - 0
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm960088k
2487 2368 None 25 Human Binding pIC50 = 8.7 8.7 31 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
5280492 2368 None 25 Human Binding pIC50 = 8.7 8.7 31 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
CHEMBL65061 2368 None 25 Human Binding pIC50 = 8.7 8.7 31 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
DB12961 2368 None 25 Human Binding pIC50 = 8.7 8.7 31 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
6444688 187426 None 30 Human Binding pIC50 = 8.7 8.7 37 2
Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49302 187426 None 30 Human Binding pIC50 = 8.7 8.7 37 2
Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4Inhibition of binding of [3H]LTB4 to receptor on nonradioactive LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
2487 2368 None 25 Human Binding pIC50 = 8.7 8.7 31 2
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
5280492 2368 None 25 Human Binding pIC50 = 8.7 8.7 31 2
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
CHEMBL65061 2368 None 25 Human Binding pIC50 = 8.7 8.7 31 2
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
DB12961 2368 None 25 Human Binding pIC50 = 8.7 8.7 31 2
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00172a020
11799000 17175 None 0 Human Binding pIC50 = 8 8.0 - 0
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
CHEMBL125611 17175 None 0 Human Binding pIC50 = 8 8.0 - 0
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
10385899 27415 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL136805 27415 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
9999755 26580 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136094 26580 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
44357534 26748 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 26748 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10071290 28108 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 28108 None 0 Human Binding pIC50 = 8 8.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
196905 111694 None 3 Human Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL328492 111694 None 3 Human Binding pIC50 = 8.0 8.0 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
11756030 58777 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL168658 58777 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3cocn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
14946858 29169 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 29169 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10407251 119145 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL342688 119145 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
15666577 9203 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1ccsc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL110402 9203 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptors at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1ccsc1CCCc1ccccc1 10.1021/jm00095a011
15666579 5629 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1 10.1021/jm00095a011
CHEMBL107760 5629 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1ccsc1CCCc1ccc(Cl)cc1 10.1021/jm00095a011
15666578 7906 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1 10.1021/jm00095a011
CHEMBL109015 7906 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 364 11 1 2 6.2 O=C(O)CCCCCCc1csc(CCCc2ccc(Cl)cc2)c1 10.1021/jm00095a011
15666603 8140 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109176 8140 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 330 11 1 2 5.5 O=C(O)CCCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
15666621 9244 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 406 12 1 2 7.2 O=C(O)CCCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL110707 9244 None 0 Human Binding pIC50 = 6 6.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 406 12 1 2 7.2 O=C(O)CCCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1 10.1021/jm00095a011
44315785 14657 None 0 Human Binding pIC50 = 6 6.0 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205307 14657 None 0 Human Binding pIC50 = 6 6.0 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL80541 14657 None 0 Human Binding pIC50 = 6 6.0 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 326 11 3 3 4.1 CCCCCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
11741184 28170 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
CHEMBL137342 28170 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
15666575 5190 None 0 Human Binding pIC50 = 5 5.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCCc1csc(CCc2ccccc2)c1 10.1021/jm00095a011
CHEMBL106055 5190 None 0 Human Binding pIC50 = 5 5.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCCc1csc(CCc2ccccc2)c1 10.1021/jm00095a011
15666597 109694 None 0 Human Binding pIC50 = 5 5.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.9 O=C(O)CCCCCCc1csc(Cc2ccccc2)c1 10.1021/jm00095a011
CHEMBL322290 109694 None 0 Human Binding pIC50 = 5 5.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.9 O=C(O)CCCCCCc1csc(Cc2ccccc2)c1 10.1021/jm00095a011
135531245 207722 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccnn2C)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL78966 207722 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccnn2C)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
10046878 28441 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 28441 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
135503765 207671 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CC(=O)O)c1 10.1021/jm00041a021
CHEMBL78605 207671 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CC(=O)O)c1 10.1021/jm00041a021
15666618 9256 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.7 CC(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL110767 9256 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.7 CC(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
10024190 25981 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL135431 25981 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10052488 59068 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.2 CCCc1c(OCCCOc2ccc(-c3coc(C)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169446 59068 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.2 CCCc1c(OCCCOc2ccc(-c3coc(C)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10069417 165003 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL422282 165003 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2cccc(Cl)c2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
18373405 31705 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL140539 31705 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
9985159 59143 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 555 14 1 8 6.4 CCCc1c(OCCCOc2ccc(-c3csc(OC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169835 59143 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 555 14 1 8 6.4 CCCc1c(OCCCOc2ccc(-c3csc(OC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44385218 59691 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/S0960-894X(97)00134-0
CHEMBL172201 59691 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cccc(C(=O)O)c1 10.1016/S0960-894X(97)00134-0
44385131 129567 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1cccc(C(=O)O)c1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL367291 129567 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1cccc(C(=O)O)c1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
6444688 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL49302 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4Binding affinity to leukotriene B4 receptor on intact human PMNs by displacing radioligand [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00046a017
18963028 14628 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205053 14628 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47716 14628 None 0 Human Binding pIC50 = 7.9 7.9 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
10343923 27791 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 27791 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
135401173 104835 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccccc1CC(=O)O 10.1021/jm00041a021
CHEMBL310870 104835 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccccc1CC(=O)O 10.1021/jm00041a021
6444688 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00070a015
CHEMBL49302 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00070a015
10053662 59680 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 565 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
CHEMBL172168 59680 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 565 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
44337707 109798 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1cc(-c2ccccc2)sc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL322985 109798 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1cc(-c2ccccc2)sc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
9980059 28367 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)n1 10.1021/jm00101a008
CHEMBL137480 28367 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(C(F)(F)F)cc2)n1 10.1021/jm00101a008
44385159 61371 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)c(C)c1 10.1016/S0960-894X(97)00134-0
CHEMBL176747 61371 None 0 Human Binding pIC50 = 5.9 5.9 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)c(C)c1 10.1016/S0960-894X(97)00134-0
6444688 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49302 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
10091738 27811 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 27811 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
6444688 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophilsInhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49302 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
Inhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophilsInhibition of specific binding of [3H]LTB4 ( 0.1 nM) to LTB4 receptor on intact human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00064a006
6444688 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00172a020
CHEMBL49302 187426 None 30 Human Binding pIC50 = 7.9 7.9 37 2
Inhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophilsInhibition of specific binding of [3H]LTB4 to Leukotriene B4 receptor in human neutrophils
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00172a020
6435820 165111 None 4 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory concentration against LTB4 receptors in human PMNsInhibitory concentration against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
CHEMBL422598 165111 None 4 Human Binding pIC50 = 6.9 6.9 - 1
Inhibitory concentration against LTB4 receptors in human PMNsInhibitory concentration against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
204058 163554 None 7 Human Binding pIC50 = 7.8 7.8 - 1
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL419948 163554 None 7 Human Binding pIC50 = 7.8 7.8 - 1
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
9805394 57600 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL166699 57600 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10385899 27415 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL136805 27415 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 393 9 1 4 5.6 COc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
10474602 25987 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 25987 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10069416 28393 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137497 28393 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10341135 29396 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 29396 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44381856 168659 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 1 7 6.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC2C(=O)O 10.1021/jm00006a002
CHEMBL435665 168659 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 1 7 6.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC2C(=O)O 10.1021/jm00006a002
9930128 60438 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.1 COc1ccc(C(=O)O)cc1NC(=O)/C=C(\C)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL175073 60438 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.1 COc1ccc(C(=O)O)cc1NC(=O)/C=C(\C)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
11726048 27606 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136953 27606 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10071290 28108 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137303 28108 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 429 9 1 3 6.5 O=C(O)CCCCCOc1cc(-c2ccc(C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10318241 28356 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137472 28356 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10250881 25078 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 408 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134698 25078 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 408 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10390056 116613 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 472 10 2 4 5.9 O=C(O)CCCCCOc1cc(-c2ccc(NC(=O)C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL336303 116613 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 472 10 2 4 5.9 O=C(O)CCCCCOc1cc(-c2ccc(NC(=O)C(F)(F)F)cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10451768 27904 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137168 27904 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
15666613 9245 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCc2ccccc2)c(CCCCCCC(=O)O)s1 10.1021/jm00095a011
CHEMBL110708 9245 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCc2ccccc2)c(CCCCCCC(=O)O)s1 10.1021/jm00095a011
44385199 59662 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 375 7 2 3 4.6 COc1ccc(C(=O)O)cc1NC(=O)CCc1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL172091 59662 None 0 Human Binding pIC50 = 5.8 5.8 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 375 7 2 3 4.6 COc1ccc(C(=O)O)cc1NC(=O)CCc1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
20704716 184831 None 0 Human Binding pIC50 = 4.8 4.8 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
CHEMBL485054 184831 None 0 Human Binding pIC50 = 4.8 4.8 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
11549986 156298 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1542 48 11 26 1.8 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)c1ccc(N/N=C/c2ccccc2)nc1 10.1021/jm050383h
CHEMBL406432 156298 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1542 48 11 26 1.8 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)c1ccc(N/N=C/c2ccccc2)nc1 10.1021/jm050383h
44386172 165885 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 397 6 2 5 4.2 COc1ccc(-c2nn[nH]n2)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL424779 165885 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 397 6 2 5 4.2 COc1ccc(-c2nn[nH]n2)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
11726048 27606 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136953 27606 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 360 9 1 3 4.8 NC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
44359651 119247 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL343124 119247 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
6441619 209240 None 18 Human Binding pIC50 = 4.8 4.8 - 1
Inhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assayInhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 209240 None 18 Human Binding pIC50 = 4.8 4.8 - 1
Inhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assayInhibitory concentration LTB4 with [3H]LTD4 in LTD4 receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
15718079 101492 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3c(C(=O)O)cccc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL297501 101492 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3c(C(=O)O)cccc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
10430674 119402 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 119402 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
10315808 26957 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 9 1 3 5.3 O=C(O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL136433 26957 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 9 1 3 5.3 O=C(O)CCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10248148 116059 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335525 116059 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
15839736 14646 None 0 Human Binding pIC50 = 6.7 6.7 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL1205143 14646 None 0 Human Binding pIC50 = 6.7 6.7 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL58534 14646 None 0 Human Binding pIC50 = 6.7 6.7 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
44385258 60388 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 7 2 3 5.1 CCOc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL174638 60388 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 7 2 3 5.1 CCOc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
6444688 187426 None 30 Human Binding pIC50 = 8.7 8.7 37 2
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
CHEMBL49302 187426 None 30 Human Binding pIC50 = 8.7 8.7 37 2
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
10022413 27666 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 27666 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10343923 27791 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137074 27791 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 453 9 1 5 6.1 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
10341242 28161 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 28161 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
6444688 187426 None 30 Human Binding pIC50 = 8.7 8.7 37 2
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 187426 None 30 Human Binding pIC50 = 8.7 8.7 37 2
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
9805394 57600 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL166699 57600 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 485 13 2 6 4.3 CCCc1c(OCCCOc2ccc(C(N)=O)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
18963032 101146 None 0 Human Binding pIC50 = 8.5 8.5 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL294987 101146 None 0 Human Binding pIC50 = 8.5 8.5 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
114999 3538 None 17 Human Binding pIC50 = 7.7 7.7 - 1
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
6156 3538 None 17 Human Binding pIC50 = 7.7 7.7 - 1
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
CHEMBL14823 3538 None 17 Human Binding pIC50 = 7.7 7.7 - 1
Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingCompound was tested for inhibitory activity against LTB4 (leukotriene) binding
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm960088k
10477988 28151 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 28151 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357546 116817 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 116817 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
178581 140341 None 1 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree CInhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C
ChEMBL 413 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnn[nH]1 10.1021/jm050383h
CHEMBL380555 140341 None 1 Human Binding pIC50 = 7.7 7.7 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree CInhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C
ChEMBL 413 9 1 5 5.5 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnn[nH]1 10.1021/jm050383h
15666615 9179 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 372 11 1 2 6.4 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)(C)C(=O)O)s1 10.1021/jm00095a011
CHEMBL110243 9179 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Capability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability of compound to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 372 11 1 2 6.4 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)(C)C(=O)O)s1 10.1021/jm00095a011
10386030 119335 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 395 9 1 3 6.1 O=C(O)CCCCCOc1cc(-c2ccccc2Cl)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL343710 119335 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 395 9 1 3 6.1 O=C(O)CCCCCOc1cc(-c2ccccc2Cl)cc(-c2ccccc2)n1 10.1021/jm00101a008
44379592 57174 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 387 10 3 4 4.7 [N-]=[N+]=Nc1ccc(CCCCC(O)/C=C/C2CCCC(O)(CC(=O)O)C2)cc1 10.1016/s0960-894x(00)00103-7
CHEMBL164721 57174 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 387 10 3 4 4.7 [N-]=[N+]=Nc1ccc(CCCCC(O)/C=C/C2CCCC(O)(CC(=O)O)C2)cc1 10.1016/s0960-894x(00)00103-7
44379573 58117 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL167465 58117 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
10021622 28608 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 10 1 3 5.7 O=C(O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137676 28608 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 363 10 1 3 5.7 O=C(O)CCCCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10430946 115556 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335142 115556 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccc(Cl)cc2n1)C(=O)O 10.1021/jm00101a007
15718082 187279 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cccc(C(=O)O)c3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL49209 187279 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cccc(C(=O)O)c3oc2c1CCC(=O)O 10.1021/jm00064a006
195214 183945 None 16 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 454 16 2 4 6.2 CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL48068 183945 None 16 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 454 16 2 4 6.2 CCCCCCCCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1021/jm00064a006
443292 5027 None 14 Human Binding pIC50 = 6.7 6.7 - 0
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 299 3 2 5 3.6 CNc1nc2c(Cc3cccnc3)c(C)c(O)c(C)c2s1 10.1021/jm00045a011
CHEMBL105139 5027 None 14 Human Binding pIC50 = 6.7 6.7 - 0
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 299 3 2 5 3.6 CNc1nc2c(Cc3cccnc3)c(C)c(O)c(C)c2s1 10.1021/jm00045a011
9934500 165696 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL424290 165696 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
10319829 26126 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 26126 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10387303 27608 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136955 27608 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
15839732 45701 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15299 45701 None 0 Human Binding pIC50 = 7.6 7.6 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
44404447 168861 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 2973 97 22 50 0.7 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)c1ccc(N/N=C/c2ccccc2)nc1)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL437275 168861 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 2973 97 22 50 0.7 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)c1ccc(N/N=C/c2ccccc2)nc1)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
10007005 120857 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.1 C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3)ccc(-c2cscn2)c1OC 10.1021/jm00006a002
CHEMBL355503 120857 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 523 13 1 7 6.1 C=CCc1c(OCCCOc2ccc3c(c2CCC)OC(C(=O)O)CC3)ccc(-c2cscn2)c1OC 10.1021/jm00006a002
10474602 25987 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL135434 25987 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 10 1 3 5.8 O=C(O)CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9999718 25074 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134697 25074 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10046386 28583 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137654 28583 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 397 8 1 3 6.2 CC(C)(CCCCOc1cc(-c2ccccc2)c2cc(Cl)ccc2n1)C(=O)O 10.1021/jm00101a007
10482767 168715 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 553 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
CHEMBL436047 168715 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 553 15 1 7 7.1 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(CCC(=O)O)CC2 10.1021/jm00006a002
44384958 59899 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccc(C)cc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL172974 59899 None 0 Human Binding pIC50 = 6.6 6.6 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccc(C)cc2)cc1 10.1016/S0960-894X(97)00134-0
135507252 208055 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 438 13 3 5 5.0 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
CHEMBL81503 208055 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 438 13 3 5 5.0 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
10483151 59590 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 571 14 1 8 7.1 CCCc1c(OCCCOc2ccc(-c3csc(SC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL171780 59590 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 571 14 1 8 7.1 CCCc1c(OCCCOc2ccc(-c3csc(SC)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
18373300 119389 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
CHEMBL344176 119389 None 0 Human Binding pIC50 = 5.6 5.6 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
10406292 28404 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 28404 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
204055 210770 None 9 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 210770 None 9 Human Binding pIC50 = 8.5 8.5 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
6444688 187426 None 30 Human Binding pIC50 = 8.5 8.5 37 2
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
CHEMBL49302 187426 None 30 Human Binding pIC50 = 8.5 8.5 37 2
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a008
6444688 187426 None 30 Human Binding pIC50 = 8.5 8.5 37 2
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
CHEMBL49302 187426 None 30 Human Binding pIC50 = 8.5 8.5 37 2
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00101a007
10023244 26170 None 1 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 26170 None 1 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
9999755 26580 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL136094 26580 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2F)cc(-c2ccccc2)n1 10.1021/jm00101a008
10091738 27811 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137089 27811 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 389 9 1 3 6.0 Cc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10475503 28016 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 28016 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10406292 28404 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137504 28404 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 361 9 1 3 5.4 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9976757 28509 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 28509 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10362331 28733 None 2 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
CHEMBL137801 28733 None 2 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
10451768 27904 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137168 27904 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 369 8 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1 10.1021/jm00101a007
10387480 28020 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137248 28020 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
10407251 119145 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL342688 119145 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1ccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)cc1 10.1021/jm00101a007
10024190 25981 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL135431 25981 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 10 1 4 5.5 CN(C)c1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10362331 28733 None 2 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
CHEMBL137801 28733 None 2 Human Binding pIC50 = 7.5 7.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 379 9 1 3 5.6 O=C(O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccc(F)cc2)n1 10.1021/jm00101a008
44403823 162039 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL415548 162039 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
129065 107601 None 24 Human Binding pIC50 = 7.5 7.5 - 0
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 377 4 3 6 3.2 Cc1c(O)c(C)c2sc(NCc3ccc(S(N)(=O)=O)cc3)nc2c1C 10.1021/jm00045a011
CHEMBL318809 107601 None 24 Human Binding pIC50 = 7.5 7.5 - 0
Tested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophilsTested for inhibitory activity against leukotriene B4 (LTB4) receptor in human neutrophils
ChEMBL 377 4 3 6 3.2 Cc1c(O)c(C)c2sc(NCc3ccc(S(N)(=O)=O)cc3)nc2c1C 10.1021/jm00045a011
18963030 14629 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205054 14629 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47725 14629 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
15666588 96929 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCCCC(C)C(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
CHEMBL265563 96929 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCCCC(C)C(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
15666614 111366 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)C(=O)O)s1 10.1021/jm00095a011
CHEMBL326650 111366 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 Cc1cc(CCCc2ccccc2)c(CCCCCC(C)C(=O)O)s1 10.1021/jm00095a011
9841175 14655 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 14655 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 14655 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
114999 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
6156 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
CHEMBL14823 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayCompound was evaluated in a human neutrophil leukotriene B4 receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00126a001
44213761 120797 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 346 9 3 3 3.7 O=C(O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL354872 120797 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 346 9 3 3 3.7 O=C(O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
114999 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
6156 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
CHEMBL14823 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Concentration inhibiting the binding of [3H]LTB4 to human neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human neutrophils
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00100a034
10387303 27608 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136955 27608 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 418 11 2 4 6.3 CC(C)Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10427789 27948 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 27948 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10455429 28970 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 431 8 1 3 6.6 CC(C)(CCCCOc1cc(-c2ccc(C(F)(F)F)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL138018 28970 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 431 8 1 3 6.6 CC(C)(CCCCOc1cc(-c2ccc(C(F)(F)F)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10430678 168512 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1cccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)c1 10.1021/jm00101a007
CHEMBL434810 168512 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 393 9 1 4 5.6 COc1cccc(-c2cc(OCCCCC(C)(C)C(=O)O)nc3ccccc23)c1 10.1021/jm00101a007
10314767 28550 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 333 7 1 3 4.7 O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137633 28550 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 333 7 1 3 4.7 O=C(O)CCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10407131 162050 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 Cc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
CHEMBL415687 162050 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 Cc1ccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)cc1 10.1021/jm00101a008
114999 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
6156 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
CHEMBL14823 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00070a015
15666630 8091 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 362 11 1 3 6.0 Cc1cc(CCCc2ccccc2)c(SCCCCCC(=O)O)s1 10.1021/jm00095a011
CHEMBL109129 8091 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 362 11 1 3 6.0 Cc1cc(CCCc2ccccc2)c(SCCCCCC(=O)O)s1 10.1021/jm00095a011
15666582 110749 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 360 12 1 3 5.5 COc1ccc(CCCc2sccc2CCCCCCC(=O)O)cc1 10.1021/jm00095a011
CHEMBL326000 110749 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 360 12 1 3 5.5 COc1ccc(CCCc2sccc2CCCCCCC(=O)O)cc1 10.1021/jm00095a011
44317392 207705 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 511 13 2 7 4.8 CCCc1c(OCCCOc2cc(O)c(C(=O)/C=C/N(C)C)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
CHEMBL78859 207705 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 511 13 2 7 4.8 CCCc1c(OCCCOc2cc(O)c(C(=O)/C=C/N(C)C)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
2487 2368 None 25 Human Binding pIC50 = 7.5 7.5 31 2
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
5280492 2368 None 25 Human Binding pIC50 = 7.5 7.5 31 2
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
CHEMBL65061 2368 None 25 Human Binding pIC50 = 7.5 7.5 31 2
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
DB12961 2368 None 25 Human Binding pIC50 = 7.5 7.5 31 2
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80853-2
114999 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
6156 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
CHEMBL14823 3538 None 17 Human Binding pIC50 = 6.5 6.5 - 1
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
10053028 59023 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 540 13 2 8 5.9 CCCc1c(OCCCOc2ccc(-c3csc(N)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169120 59023 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 540 13 2 8 5.9 CCCc1c(OCCCOc2ccc(-c3csc(N)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
6441619 209240 None 18 Human Binding pIC50 = 5.5 5.5 - 1
Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayInhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 209240 None 18 Human Binding pIC50 = 5.5 5.5 - 1
Inhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assayInhibitory concentration against LTB4 with [3H]- fMLP in receptor binding assay
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
18963062 14788 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1206683 14788 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL295799 14788 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
15666601 6148 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.7 O=C(O)CCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL108094 6148 None 0 Human Binding pIC50 = 5.5 5.5 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 302 9 1 2 4.7 O=C(O)CCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
15839733 45650 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15295 45650 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
44296838 195100 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Compound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itselfCompound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itself
ChEMBL 334 14 2 2 5.4 CCCCC/C=C\C[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O 10.1016/S0960-894X(01)80795-2
CHEMBL53967 195100 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Compound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itselfCompound was tested for its antagonist activity in a LTB4 human neutrophil receptor binding assay using the natural ligand itself
ChEMBL 334 14 2 2 5.4 CCCCC/C=C\C[C@@H](C)/C=C/C=C/C=C/[C@@H](O)CCCC(=O)O 10.1016/S0960-894X(01)80795-2
15839729 209346 None 1 Human Binding pIC50 = 7.4 7.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
CHEMBL15559 209346 None 1 Human Binding pIC50 = 7.4 7.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
CHEMBL90788 209346 None 1 Human Binding pIC50 = 7.4 7.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm960088k
15839729 209346 None 1 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15559 209346 None 1 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL90788 209346 None 1 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
9955657 209113 None 17 Human Binding pIC50 = 8.4 8.4 - 0
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 455 13 2 5 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCCOc1ccc(C(=N)N)cc1 10.1021/jm960088k
CHEMBL89326 209113 None 17 Human Binding pIC50 = 8.4 8.4 - 0
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 455 13 2 5 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCCOc1ccc(C(=N)N)cc1 10.1021/jm960088k
9893718 208959 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL292768 208959 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL88337 208959 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
9893718 208959 None 0 Human Binding pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL292768 208959 None 0 Human Binding pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL88337 208959 None 0 Human Binding pIC50 = 8.4 8.4 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10046878 28441 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137531 28441 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 405 10 1 4 5.7 COc1ccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
9976757 28509 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137581 28509 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 1 3 5.7 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10430674 119402 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
CHEMBL344230 119402 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 393 9 1 3 5.8 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2F)n1)C(=O)O 10.1021/jm00101a008
9912012 162298 None 0 Human Binding pIC50 = 8.4 8.4 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL416277 162298 None 0 Human Binding pIC50 = 8.4 8.4 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
10364772 28168 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 28168 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
204055 210770 None 9 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 210770 None 9 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135543808 208042 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 480 11 3 6 4.9 CCCc1c(OCCCOc2cc(O)c(-c3cc[nH]n3)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
CHEMBL81401 208042 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 480 11 3 6 4.9 CCCc1c(OCCCOc2cc(O)c(-c3cc[nH]n3)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00041a021
132379 111795 None 16 Human Binding pIC50 = 8.3 8.3 - 1
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm9506985
CHEMBL328712 111795 None 16 Human Binding pIC50 = 8.3 8.3 - 1
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm9506985
132379 111795 None 16 Human Binding pIC50 = 8.3 8.3 - 1
Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophils
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111795 None 16 Human Binding pIC50 = 8.3 8.3 - 1
Concentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophilsConcentration inhibiting the binding of [3H]LTB4 to human whole cell neutrophils
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
10292143 116661 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL336665 116661 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL48667 116661 None 0 Human Binding pIC50 = 8.3 8.3 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10292143 116661 None 0 Human Binding pIC50 = 8.3 8.3 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL336665 116661 None 0 Human Binding pIC50 = 8.3 8.3 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL48667 116661 None 0 Human Binding pIC50 = 8.3 8.3 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
10090758 59017 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 373 9 2 3 3.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL169055 59017 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 373 9 2 3 3.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccccc2)C1 10.1016/s0960-894x(00)00103-7
10047140 27615 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 27615 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10001576 28389 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 28389 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
9999718 25074 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL134697 25074 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 378 8 2 4 5.1 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
14946858 29169 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL138174 29169 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 375 9 0 4 5.5 COC(=O)CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10068808 27718 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 387 8 1 5 4.9 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137030 27718 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 387 8 1 5 4.9 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
18373405 31705 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL140539 31705 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 525 7 1 3 7.3 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Br)cc12 10.1016/j.bmcl.2003.08.070
18373357 116857 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL337790 116857 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
44359651 119247 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL343124 119247 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 481 7 1 3 7.2 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(Cl)cc12 10.1016/j.bmcl.2003.08.070
10021742 9458 None 6 Human Binding pIC50 = 5.4 5.4 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 9458 None 6 Human Binding pIC50 = 5.4 5.4 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
10248148 116059 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL335525 116059 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 363 8 1 3 5.6 CC(C)(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
44270188 51401 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15817 51401 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
18963059 14630 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205055 14630 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47726 14630 None 0 Human Binding pIC50 = 7.4 7.4 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
204055 210770 None 9 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL99099 210770 None 9 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 537 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
60490 209719 None 60 Human Binding pIC50 = 6.4 6.4 - 0
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
ChEMBL 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O 10.1021/jm950725r
CHEMBL93 209719 None 60 Human Binding pIC50 = 6.4 6.4 - 0
In vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophilsIn vitro activities of Leukotriene B4 receptor (LTB4) in human neutrophils
ChEMBL 236 2 2 3 2.7 CC(c1cc2ccccc2s1)N(O)C(N)=O 10.1021/jm950725r
114999 3538 None 17 Human Binding pIC50 = 7.4 7.4 - 1
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
6156 3538 None 17 Human Binding pIC50 = 7.4 7.4 - 1
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
CHEMBL14823 3538 None 17 Human Binding pIC50 = 7.4 7.4 - 1
Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00006a002
9934323 100307 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
CHEMBL288758 100307 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00064a006
10170399 14828 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL1207275 14828 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL384950 14828 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [111In]-(17)] as radioligand in pH 7.2 buffer, for 1 hr at 37 degree C; (n=2)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
10415107 14904 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
CHEMBL1207951 14904 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
CHEMBL462734 14904 None 0 Human Binding pIC50 = 4.4 4.4 - 0
Displacement of [3H]LTB4 from LTB4 receptor in human neutrophilsDisplacement of [3H]LTB4 from LTB4 receptor in human neutrophils
ChEMBL 504 4 2 7 4.1 CC1(C)CCC[C@@]2(C)[C@H]1CC[C@@]1(C)OCc3c(OS(=O)(=O)O)ccc(OS(=O)(=O)O)c3C[C@H]21 10.1021/np50120a024
10022413 27666 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136991 27666 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 376 9 2 4 5.0 Nc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10170399 14828 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL1207275 14828 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
CHEMBL384950 14828 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer upon incubation for 1 hr at 37 degree C; (n=4)
ChEMBL 1018 33 4 16 7.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)c1ccc(N/N=C/c2ccccc2S(=O)(=O)O)nc1 10.1021/jm050383h
15666610 7907 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109016 7907 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 316 10 1 2 5.1 O=C(O)CCCCCc1sccc1CCCc1ccccc1 10.1021/jm00095a011
44385160 61372 None 0 Human Binding pIC50 = 5.3 5.3 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2C)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL176748 61372 None 0 Human Binding pIC50 = 5.3 5.3 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 5.0 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2C)cc1 10.1016/S0960-894X(97)00134-0
19427041 14649 None 0 Human Binding pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL1205171 14649 None 0 Human Binding pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL60881 14649 None 0 Human Binding pIC50 = 7.3 7.3 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10023244 26170 None 1 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135671 26170 None 1 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 389 9 1 3 6.1 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10047140 27615 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL136960 27615 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2cccc(Cl)c2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10475503 28016 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137247 28016 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 9 2 4 5.3 CC(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10318241 28356 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL137472 28356 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 390 10 2 4 5.5 CNc1ccc(-c2cc(OCCCCCC(=O)O)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10001576 28389 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137494 28389 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccc(Cl)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10436331 120608 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 2 7 5.0 CCCc1c(OCCCOc2ccc(-c3c[nH]nn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL354553 120608 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 509 13 2 7 5.0 CCCc1c(OCCCOc2ccc(-c3c[nH]nn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
15237280 58118 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 511 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167474 58118 None 0 Human Binding pIC50 = 8.3 8.3 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 511 13 2 6 4.6 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(01)80853-2
3368 1173 None 29 Human Binding pIC50 = 8.3 8.3 - 0
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
9867257 1173 None 29 Human Binding pIC50 = 8.3 8.3 - 0
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
CHEMBL51770 1173 None 29 Human Binding pIC50 = 8.3 8.3 - 0
Tested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibitionTested for binding activity against [3H]LTB4 to whole human neutrophil with halh maximal inhibition
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm00046a001
135543742 207846 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CCC(=O)O)c1 10.1021/jm00041a021
CHEMBL79991 207846 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1cccc(CCC(=O)O)c1 10.1021/jm00041a021
44348541 16827 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 323 7 1 2 3.0 CN(CCc1ccccc1)C(=O)Cc1cccc(/C=C/C(=O)O)c1 10.1021/jm9506985
CHEMBL124717 16827 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 323 7 1 2 3.0 CN(CCc1ccccc1)C(=O)Cc1cccc(/C=C/C(=O)O)c1 10.1021/jm9506985
44357534 26748 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
CHEMBL136243 26748 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 385 9 0 6 4.7 c1ccc(-c2cc(OCCCCCn3cnnn3)nc(-c3ccccc3)c2)cc1 10.1021/jm00101a008
10341135 29396 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL138380 29396 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 403 10 1 3 6.5 CC(C)(CCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10427789 27948 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137201 27948 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 347 8 1 3 5.0 O=C(O)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10363959 28521 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137594 28521 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
10387480 28020 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
CHEMBL137248 28020 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes
ChEMBL 421 8 1 5 5.6 CC(C)(CCCCOc1cc(-c2ccc(Cl)cc2)c2ccccc2n1)c1nnn[nH]1 10.1021/jm00101a007
11725988 27994 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 359 8 1 5 4.2 c1ccc(-c2cc(OCCCCCc3nnn[nH]3)nc3ccccc23)cc1 10.1021/jm00101a007
CHEMBL137234 27994 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 359 8 1 5 4.2 c1ccc(-c2cc(OCCCCCc3nnn[nH]3)nc3ccccc23)cc1 10.1021/jm00101a007
10340408 118629 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1cccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)c1 10.1021/jm00101a008
CHEMBL341565 118629 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 391 10 1 4 5.4 COc1cccc(-c2cc(-c3ccccc3)cc(OCCCCCC(=O)O)n2)c1 10.1021/jm00101a008
18373300 119389 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
CHEMBL344176 119389 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 492 8 1 5 6.5 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc([N+](=O)[O-])cc12 10.1016/j.bmcl.2003.08.070
15666581 5650 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.2 O=C(O)CCCCCCc1csc(CCCc2ccc(O)cc2)c1 10.1021/jm00095a011
CHEMBL107781 5650 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.2 O=C(O)CCCCCCc1csc(CCCc2ccc(O)cc2)c1 10.1021/jm00095a011
10391552 120386 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3c[nH]cn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL352863 120386 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3c[nH]cn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135507183 208100 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2ccn[nH]2)c(O)cc1OCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
CHEMBL81817 208100 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 396 10 3 5 3.8 CCc1cc(-c2ccn[nH]2)c(O)cc1OCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
44403823 162039 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL415548 162039 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 3125 109 25 54 -4.2 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](NC(=O)CN(CCN(CCN(CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
135507225 104276 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 424 12 3 5 4.6 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
CHEMBL309883 104276 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 424 12 3 5 4.6 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(CC(=O)O)cc1 10.1021/jm00041a021
10247237 28495 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 8 1 3 5.2 CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL137570 28495 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 349 8 1 3 5.2 CC(CCCCOc1cc(-c2ccccc2)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
10032156 59034 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 647 16 1 8 8.6 CCCc1c(OCCCOc2ccc(-c3csc(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169246 59034 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 647 16 1 8 8.6 CCCc1c(OCCCOc2ccc(-c3csc(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
9906324 14625 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205046 14625 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL46820 14625 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
9906324 14625 None 0 Human Binding pIC50 = 8.2 8.2 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL1205046 14625 None 0 Human Binding pIC50 = 8.2 8.2 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL46820 14625 None 0 Human Binding pIC50 = 8.2 8.2 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
9865985 28681 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137759 28681 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 9 1 5 5.2 O=C(O)CCCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1 10.1021/jm00101a008
9978895 119040 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
CHEMBL342416 119040 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor of human polymorphonuclear leukocytes
ChEMBL 409 9 1 3 6.3 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2Cl)n1)C(=O)O 10.1021/jm00101a008
6450158 187280 None 20 Human Binding pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49210 187280 None 20 Human Binding pIC50 = 8.2 8.2 - 1
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
6450158 187280 None 20 Human Binding pIC50 = 8.2 8.2 - 1
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 187280 None 20 Human Binding pIC50 = 8.2 8.2 - 1
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
135516891 157608 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 384 10 3 6 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL407983 157608 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 384 10 3 6 3.8 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
18963040 14874 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL1207571 14874 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL416259 14874 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10364772 28168 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137341 28168 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 419 9 1 5 5.4 CC(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10092630 27829 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 27829 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
132425 6867 None 3 Human Binding pIC50 = 7.2 7.2 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 CC(C)(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL108415 6867 None 3 Human Binding pIC50 = 7.2 7.2 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 358 11 1 2 6.1 CC(C)(CCCCCc1sccc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
11799000 17175 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Compound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMNCompound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMN
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
CHEMBL125611 17175 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Compound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMNCompound was evaluated for LTB4 receptor binding, obtained from radioligand binding assay using human intact neutrophils PMN
ChEMBL 482 9 1 4 5.1 CN(O)C(=O)c1cc(CC(=O)N(C)CCc2ccccc2)c2cccc(OCc3ccccc3)c2c1 10.1021/jm950699x
10319829 26126 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL135612 26126 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 417 11 1 3 6.9 CC(C)(CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10363959 28521 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137594 28521 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 406 10 1 5 5.3 O=C(O)CCCCCOc1cc(-c2ccc([N+](=O)[O-])cc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
15666631 8089 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.0 O=C(O)CCCCCC(O)c1sccc1CCCc1ccccc1 10.1021/jm00095a011
CHEMBL109128 8089 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 346 11 2 3 5.0 O=C(O)CCCCCC(O)c1sccc1CCCc1ccccc1 10.1021/jm00095a011
44379572 120364 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 540 10 2 4 5.3 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])c(I)c2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL352717 120364 None 0 Human Binding pIC50 = 5.2 5.2 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 540 10 2 4 5.3 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])c(I)c2)C1 10.1016/s0960-894x(00)00103-7
9849151 59113 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3cc[nH]n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169683 59113 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 508 13 2 6 5.6 CCCc1c(OCCCOc2ccc(-c3cc[nH]n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
15839731 49465 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15648 49465 None 0 Human Binding pIC50 = 7.2 7.2 - 1
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
10339300 130293 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL367943 130293 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 373 6 2 3 4.7 COc1ccc(C(=O)O)cc1NC(=O)/C=C/c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
10341242 28161 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
CHEMBL137336 28161 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 405 10 1 4 5.7 COc1cccc(-c2cc(OCCCCC(C)C(=O)O)nc(-c3ccccc3)c2)c1 10.1021/jm00101a008
10477988 28151 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137330 28151 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 433 9 1 5 5.8 CC(C)(CCCCOc1cc(-c2ccc3c(c2)OCO3)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
44357546 116817 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
CHEMBL337563 116817 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 399 9 0 6 5.2 CC(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)n1cnnn1 10.1021/jm00101a008
9911868 18041 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determinedInhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determined
ChEMBL 455 11 1 7 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCOc1ccc2c(N)noc2c1 10.1016/S0960-894X(97)00025-5
CHEMBL126463 18041 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Inhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determinedInhibitory concentration of compound against Leukotriene B4 receptor binding to human neutrophils was determined
ChEMBL 455 11 1 7 4.9 COc1cc(C(=O)N(C(C)C)C(C)C)ccc1OCCCCOc1ccc2c(N)noc2c1 10.1016/S0960-894X(97)00025-5
15666586 108623 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCCCCC(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
CHEMBL320258 108623 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 344 11 1 2 5.8 Cc1cc(CCCCCCC(=O)O)c(CCCc2ccccc2)s1 10.1021/jm00095a011
44379573 58117 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
CHEMBL167465 58117 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Compound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranesCompound was tested for inhibition against binding of radioligand [3H]LTB4 to Leukotriene B4 receptor in human neutrophil membranes
ChEMBL 414 10 2 4 4.7 CN(C)C(=O)CC1(O)CCCC(/C=C/C(O)CCCCc2ccc(N=[N+]=[N-])cc2)C1 10.1016/s0960-894x(00)00103-7
10019853 28544 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 335 8 1 3 4.9 O=C(O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
CHEMBL137625 28544 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 335 8 1 3 4.9 O=C(O)CCCCCOc1cc(-c2ccccc2)c2ccccc2n1 10.1021/jm00101a007
10337448 28115 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 342 8 0 3 5.9 N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
CHEMBL137307 28115 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.
ChEMBL 342 8 0 3 5.9 N#CCCCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm00101a008
9841175 14655 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 14655 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 14655 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
44315539 14803 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1206776 14803 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL305933 14803 None 0 Human Binding pIC50 = 4.2 4.2 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 312 10 3 3 3.7 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CCCC(=O)O)C1 10.1016/0960-894X(96)00424-6
135430350 168157 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1ccc(CCC(=O)O)cc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
CHEMBL432363 168157 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1ccc(CCC(=O)O)cc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
10021742 9458 None 6 Human Binding pIC50 = 6.1 6.1 - 1
Binding affinity to LTB4 receptor in human U937 cells by whole cell assayBinding affinity to LTB4 receptor in human U937 cells by whole cell assay
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 9458 None 6 Human Binding pIC50 = 6.1 6.1 - 1
Binding affinity to LTB4 receptor in human U937 cells by whole cell assayBinding affinity to LTB4 receptor in human U937 cells by whole cell assay
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
10349070 130956 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 630 16 2 7 7.9 CCCc1c(OCCCOc2ccc(-c3c[nH]c(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL368540 130956 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.Binding affinity towards Leukotriene B4 (LTB4) Receptor. Experiment conducted in the absence of NDGA.
ChEMBL 630 16 2 7 7.9 CCCc1c(OCCCOc2ccc(-c3c[nH]c(SCc4ccccc4)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
10481412 59805 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3ccno3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL172628 59805 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 509 13 1 7 5.9 CCCc1c(OCCCOc2ccc(-c3ccno3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44384957 166333 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 389 7 2 4 4.3 COc1ccc(C(=O)O)cc1NC(=O)CC(=O)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL426773 166333 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 389 7 2 4 4.3 COc1ccc(C(=O)O)cc1NC(=O)CC(=O)c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
44403368 161421 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 2750 92 21 47 -1.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](N)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
CHEMBL412510 161421 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)Inhibitory concentration against human leukotriene B4 receptor using competing agent [3H]-LTB4 as radioligand in pH 7.2 buffer, for 1 h at 37 degree C; (n=2)
ChEMBL 2750 92 21 47 -1.6 CC(C)(CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1)c1nnnn1CCCCC(=O)NCCCOCCOCCOCCCNC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)[C@H](CS(=O)(=O)O)NC(=O)CC[C@H](N)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)N[C@@H](CS(=O)(=O)O)C(=O)NCCCOCCOCCOCCCNC(=O)CCCCn1nnnc1C(C)(C)CCCCOc1cc(-c2ccccc2)cc(-c2ccccc2)n1 10.1021/jm050383h
3368 1173 None 29 Human Binding pIC50 = 8.1 8.1 - 0
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
9867257 1173 None 29 Human Binding pIC50 = 8.1 8.1 - 0
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
CHEMBL51770 1173 None 29 Human Binding pIC50 = 8.1 8.1 - 0
Compound was tested for inhibitory activity against Leukotriene B4 receptor bindingCompound was tested for inhibitory activity against Leukotriene B4 receptor binding
ChEMBL 428 5 2 3 5.5 OC(=O)C1(CCCC1)c1ccc2c(c1)OC[C@@H]([C@H]2O)Cc1ccc(cc1)c1ccccc1 10.1021/jm960088k
9958915 58140 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
CHEMBL167669 58140 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory activity against leukotriene B4 receptorInhibitory activity against leukotriene B4 receptor
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@@H](CCC(=O)O)CC2 10.1016/S0960-894X(01)80853-2
10741106 117866 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 426 9 0 4 4.7 CN(CCc1ccccc1)C(=O)Cn1cc(C=O)c2cc(OCc3ccccc3)ccc21 10.1021/jm950699x
CHEMBL340180 117866 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Compound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membraneCompound was evaluated for Leukotriene B4 receptor binding, obtained from radioligand binding assay using guinea pig spleen cell membrane
ChEMBL 426 9 0 4 4.7 CN(CCc1ccccc1)C(=O)Cn1cc(C=O)c2cc(OCc3ccccc3)ccc21 10.1021/jm950699x
15666623 167899 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
CHEMBL430520 167899 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Capability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 MCapability to inhibit the binding of [3H]LTB4 to guinea pig spleen Leukotriene B4 receptor at the concentration of 10e-5 M
ChEMBL 434 12 1 2 7.8 CC(C)(CCCCCc1sc(-c2ccccc2)cc1CCCc1ccccc1)C(=O)O 10.1021/jm00095a011
9841175 14655 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205297 14655 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
CHEMBL77513 14655 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 346 9 3 3 3.7 O=C(O)C[C@]1(O)CCC[C@H](/C=C/C(O)CCCCc2ccccc2)C1 10.1016/0960-894X(96)00424-6
11740566 119511 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 381 8 1 3 5.7 CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
CHEMBL345047 119511 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 381 8 1 3 5.7 CC(C)(CCCCOc1cc(-c2ccccc2F)c2ccccc2n1)C(=O)O 10.1021/jm00101a007
9934500 165696 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL424290 165696 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory concentration against LTB4 receptor determined in human neutrophils PMN assayInhibitory concentration against LTB4 receptor determined in human neutrophils PMN assay
ChEMBL 472 7 1 4 6.4 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C#N)cc12 10.1016/j.bmcl.2003.08.070
44315583 14654 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL1205289 14654 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
CHEMBL76530 14654 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandCompound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligand
ChEMBL 284 8 3 3 2.9 CCCCCC(O)/C=C/[C@H]1CCC[C@@](O)(CC(=O)O)C1 10.1016/0960-894X(96)00424-6
9976891 28175 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1c(OCCCCC(C)(C)C(=O)O)nc2ccccc2c1-c1ccccc1 10.1021/jm00101a007
CHEMBL137346 28175 None 0 Human Binding pIC50 = 5.1 5.1 - 0
Inhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranesInhibition of [3H]LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes
ChEMBL 377 8 1 3 5.9 Cc1c(OCCCCC(C)(C)C(=O)O)nc2ccccc2c1-c1ccccc1 10.1021/jm00101a007
135543741 208054 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.7 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(C(=O)O)cc1 10.1021/jm00041a021
CHEMBL81489 208054 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.7 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCCCOc1ccc(C(=O)O)cc1 10.1021/jm00041a021
44385920 61402 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O 10.1016/S0960-894X(97)00134-0
CHEMBL176974 61402 None 0 Human Binding pIC50 = 6.1 6.1 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 343 5 2 2 4.7 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1ccccc1C(=O)O 10.1016/S0960-894X(97)00134-0
15718085 101400 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3ccc(C(=O)O)cc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
CHEMBL296869 101400 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophilsInhibition of specific binding of LTB4 ( 0.1 nM) to receptors on intact human neutrophils
ChEMBL 468 14 2 5 6.2 CCCCCCCCCCOc1cc2oc3ccc(C(=O)O)cc3c(=O)c2cc1CCC(=O)O 10.1021/jm00064a006
135507273 207753 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1c(CCC(=O)O)cccc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
CHEMBL79233 207753 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 452 13 3 5 5.2 CCCc1c(CCC(=O)O)cccc1OCCCOc1cc(O)c(-c2cc[nH]n2)cc1CC 10.1021/jm00041a021
122023 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL15766 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL45460 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
In vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophilsIn vitro antagonistic activity towards LTB4 receptor was evaluated by inhibition of binding of [3H]LTB4 to human neutrophils
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
4534 192011 None 61 Human Binding pIC50 = 7.1 7.1 - 0
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
ChEMBL 302 5 4 4 3.6 CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 10.1021/jm00085a019
CHEMBL52 192011 None 61 Human Binding pIC50 = 7.1 7.1 - 0
The compound was tested for its inhibitory activity against LTB4 in human PMNThe compound was tested for its inhibitory activity against LTB4 in human PMN
ChEMBL 302 5 4 4 3.6 CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1 10.1021/jm00085a019
122023 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL15766 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL45460 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Compound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand to Leukotriene B4 receptor in human neutrophil binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
122023 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL15766 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL45460 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Inhibition against LTB4 receptor in human neutrophilInhibition against LTB4 receptor in human neutrophil
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
122023 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
CHEMBL15766 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
CHEMBL45460 50810 None 43 Human Binding pIC50 = 7.1 7.1 30 2
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1021/jm00041a021
135500104 163868 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
CHEMBL420576 163868 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 410 11 3 5 4.2 CCc1cc(-c2cc[nH]n2)c(O)cc1OCCCOc1ccc(CCC(=O)O)cc1 10.1021/jm00041a021
10347709 59119 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 557 13 2 8 6.6 CCCc1c(OCCCOc2ccc(-c3csc(S)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL169722 59119 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 557 13 2 8 6.6 CCCc1c(OCCCOc2ccc(-c3csc(S)n3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
135457469 105696 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccn(C)n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
CHEMBL312483 105696 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]Leukotriene B4 binding to human PMNInhibition of [3H]Leukotriene B4 binding to human PMN
ChEMBL 398 10 2 7 3.8 CCc1cc(-c2ccn(C)n2)c(O)cc1OCCCCCC(C)(C)c1nnn[nH]1 10.1021/jm00041a021
10092630 27829 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
CHEMBL137104 27829 None 0 Human Binding pIC50 = 8.0 8.0 - 0
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.
ChEMBL 404 9 2 4 5.7 CC(C)(CCCCOc1cc(-c2ccc(N)cc2)cc(-c2ccccc2)n1)C(=O)O 10.1021/jm00101a008
10737187 15526 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 359 8 0 2 4.5 CN(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 10.1021/jm9506985
CHEMBL121748 15526 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Compound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cellsCompound tested for binding affinity against Leukotriene B4 receptor using radioligand binding assay from Human PMN cells
ChEMBL 359 8 0 2 4.5 CN(CCc1ccccc1)C(=O)Cc1ccc(OCc2ccccc2)cc1 10.1021/jm9506985
18373357 116857 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
CHEMBL337790 116857 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Inhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assayInhibitory concentration against LTB4 receptor determined in mast cell line MC-9 assay
ChEMBL 461 7 1 3 6.9 COc1cc(C(=O)O)ccc1Cc1cn(C(c2ccccc2)c2ccccc2)c2ccc(C)cc12 10.1016/j.bmcl.2003.08.070
44386171 61394 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 377 5 2 2 5.4 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cc(C(=O)O)ccc1Cl 10.1016/S0960-894X(97)00134-0
CHEMBL176903 61394 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 377 5 2 2 5.4 O=C(/C=C/c1ccc(-c2ccccc2)cc1)Nc1cc(C(=O)O)ccc1Cl 10.1016/S0960-894X(97)00134-0
10052575 58971 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 525 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
CHEMBL168944 58971 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity for Leukotriene B4 (LTB4) receptorBinding affinity for Leukotriene B4 (LTB4) receptor
ChEMBL 525 13 1 7 6.4 CCCc1c(OCCCOc2ccc(-c3cscn3)c(OC)c2CCC)ccc2c1OC(C(=O)O)CC2 10.1021/jm00006a002
44385966 60446 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 4.8 COc1ccc(C(=O)O)cc1NC(=O)[C@H]1C[C@@H]1c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
CHEMBL175128 60446 None 0 Human Binding pIC50 = 6.0 6.0 - 0
In vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophilsIn vitro binding affinity towards LTB4 receptor determined by measuring the displacement of [3H]LTB4 from isolated neutrophils
ChEMBL 387 6 2 3 4.8 COc1ccc(C(=O)O)cc1NC(=O)[C@H]1C[C@@H]1c1ccc(-c2ccccc2)cc1 10.1016/S0960-894X(97)00134-0
25114442 3061 None 48 Human Binding pIC50 = 5.0 5.0 -1288 2
LTB4 (h) (BLT1) CEREP ligand profilingLTB4 (h) (BLT1) CEREP ligand profiling
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
5817 3061 None 48 Human Binding pIC50 = 5.0 5.0 -1288 2
LTB4 (h) (BLT1) CEREP ligand profilingLTB4 (h) (BLT1) CEREP ligand profiling
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
CHEMBL3286797 3061 None 48 Human Binding pIC50 = 5.0 5.0 -1288 2
LTB4 (h) (BLT1) CEREP ligand profilingLTB4 (h) (BLT1) CEREP ligand profiling
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
DB12024 3061 None 48 Human Binding pIC50 = 5.0 5.0 -1288 2
LTB4 (h) (BLT1) CEREP ligand profilingLTB4 (h) (BLT1) CEREP ligand profiling
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
25114442 3061 None 48 Human Binding pIC50 = 5.0 5.0 -1288 2
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
5817 3061 None 48 Human Binding pIC50 = 5.0 5.0 -1288 2
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
CHEMBL3286797 3061 None 48 Human Binding pIC50 = 5.0 5.0 -1288 2
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
DB12024 3061 None 48 Human Binding pIC50 = 5.0 5.0 -1288 2
Selectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4RSelectivity interaction (CEREP ligand profiling ) EUB0000351a LTB4R
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL5212743
192617 100806 None 18 Human Binding pKi = 10.4 10.4 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292782 100806 None 18 Human Binding pKi = 10.4 10.4 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 100806 None 18 Human Binding pKi = 10.4 10.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292782 100806 None 18 Human Binding pKi = 10.4 10.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
19600933 205258 None 0 Human Binding pKi = 10.1 10.1 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL62265 205258 None 0 Human Binding pKi = 10.1 10.1 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
10745838 118126 None 0 Human Binding pKi = 10.0 10.0 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL340460 118126 None 0 Human Binding pKi = 10.0 10.0 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
2487 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
5280492 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
CHEMBL65061 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
DB12961 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80999-9
2487 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
5280492 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
CHEMBL65061 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
DB12961 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
2487 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
5280492 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
CHEMBL65061 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
DB12961 2368 None 25 Human Binding pKi = 9.9 9.9 31 2
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
132379 111795 None 16 Human Binding pKi = 9.9 9.9 - 1
Affinity for guinea pig PMN LTB-4 receptors.Affinity for guinea pig PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111795 None 16 Human Binding pKi = 9.9 9.9 - 1
Affinity for guinea pig PMN LTB-4 receptors.Affinity for guinea pig PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
10120811 96505 None 0 Human Binding pKi = 9.9 9.9 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL262231 96505 None 0 Human Binding pKi = 9.9 9.9 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 100806 None 18 Human Binding pKi = 9.3 9.3 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00046a017
CHEMBL292782 100806 None 18 Human Binding pKi = 9.3 9.3 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00046a017
192617 100806 None 18 Human Binding pKi = 9.3 9.3 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
CHEMBL292782 100806 None 18 Human Binding pKi = 9.3 9.3 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm960088k
192617 100806 None 18 Human Binding pKi = 9.3 9.3 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292782 100806 None 18 Human Binding pKi = 9.3 9.3 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
192617 100806 None 18 Human Binding pKi = 9.3 9.3 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292782 100806 None 18 Human Binding pKi = 9.3 9.3 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 600 12 3 7 6.6 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
10745838 118126 None 0 Human Binding pKi = 9.2 9.2 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL340460 118126 None 0 Human Binding pKi = 9.2 9.2 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 582 12 3 7 6.4 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
6441619 209240 None 18 Human Binding pKi = 9.1 9.1 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
CHEMBL90214 209240 None 18 Human Binding pKi = 9.1 9.1 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960248s
6441619 209240 None 18 Human Binding pKi = 9.1 9.1 - 1
Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorCompound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptor
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960088k
CHEMBL90214 209240 None 18 Human Binding pKi = 9.1 9.1 - 1
Compound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptorCompound was tested for binding affinity against human neutrophil LTB4 (leukotriene) receptor
ChEMBL 459 9 1 4 6.4 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccccc1 10.1021/jm960088k
9850643 210145 None 0 Human Binding pKi = 9 9.0 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 554 19 2 6 6.4 CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm00046a017
CHEMBL95453 210145 None 0 Human Binding pKi = 9 9.0 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 554 19 2 6 6.4 CCCc1c(OCCCCCCc2cccc(OCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm00046a017
15658147 9586 None 0 Human Binding pKi = 9 9.0 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
CHEMBL112487 9586 None 0 Human Binding pKi = 9 9.0 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
CHEMBL112520 9586 None 0 Human Binding pKi = 9 9.0 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a013
9850974 208725 None 0 Human Binding pKi = 9 9.0 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 568 20 2 6 6.8 CCCc1c(OCCCCCCc2cccc(OCCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm960088k
CHEMBL86900 208725 None 0 Human Binding pKi = 9 9.0 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 568 20 2 6 6.8 CCCc1c(OCCCCCCc2cccc(OCCCCCC(=O)O)c2CCC(=O)O)ccc2c1OCCC2=O 10.1021/jm960088k
15658147 9586 None 0 Human Binding pKi = 9 9.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL112487 9586 None 0 Human Binding pKi = 9 9.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL112520 9586 None 0 Human Binding pKi = 9 9.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 411 13 3 4 5.2 CCCCCCCCC(O)/C=C/c1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
10120811 96505 None 0 Human Binding pKi = 9.0 9.0 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL262231 96505 None 0 Human Binding pKi = 9.0 9.0 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cccc(Oc2ccc(C(=O)O)cc2)c1CCC(=O)O 10.1016/S0960-894X(01)80105-0
19600933 205258 None 0 Human Binding pKi = 9.0 9.0 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL62265 205258 None 0 Human Binding pKi = 9.0 9.0 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 534 13 3 5 5.8 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc(C#CCCC(=O)O)cc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
9893718 208959 None 0 Human Binding pKi = 8.9 8.9 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL292768 208959 None 0 Human Binding pKi = 8.9 8.9 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL88337 208959 None 0 Human Binding pKi = 8.9 8.9 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1016/S0960-894X(01)80999-9
10529082 18825 None 0 Human Binding pKi = 8.9 8.9 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 489 10 1 5 6.4 COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL127913 18825 None 0 Human Binding pKi = 8.9 8.9 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 489 10 1 5 6.4 COc1ccc(CCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
9893718 208959 None 0 Human Binding pKi = 8.9 8.9 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292768 208959 None 0 Human Binding pKi = 8.9 8.9 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL88337 208959 None 0 Human Binding pKi = 8.9 8.9 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
204058 163554 None 7 Human Binding pKi = 8.9 8.9 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm00046a017
CHEMBL419948 163554 None 7 Human Binding pKi = 8.9 8.9 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 539 15 2 6 5.4 CCCc1c(OCCCOc2ccc(C(=O)NC)c(OC)c2CC2CC2)ccc2c1O[C@H](CCC(=O)O)CC2 10.1021/jm00046a017
10529241 18519 None 0 Human Binding pKi = 8.9 8.9 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 493 9 1 4 7.1 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1 10.1021/jm960248s
CHEMBL127376 18519 None 0 Human Binding pKi = 8.9 8.9 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 493 9 1 4 7.1 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(Cl)cc1 10.1021/jm960248s
10648186 18174 None 1 Human Binding pKi = 8.9 8.9 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 473 10 1 4 6.8 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1 10.1021/jm960248s
CHEMBL126976 18174 None 1 Human Binding pKi = 8.9 8.9 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 473 10 1 4 6.8 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCCc1ccccc1 10.1021/jm960248s
11798848 16539 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 477 9 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1 10.1021/jm960248s
CHEMBL123722 16539 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 477 9 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCCc1ccc(F)cc1 10.1021/jm960248s
9958441 116898 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 517 12 1 5 7.2 COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL337995 116898 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 517 12 1 5 7.2 COc1ccc(CCCCOc2ccc(CSc3c(Cl)cccc3Cl)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
2487 2368 None 25 Human Binding pKi = 8.7 8.7 31 2
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
5280492 2368 None 25 Human Binding pKi = 8.7 8.7 31 2
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
CHEMBL65061 2368 None 25 Human Binding pKi = 8.7 8.7 31 2
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
DB12961 2368 None 25 Human Binding pKi = 8.7 8.7 31 2
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1016/S0960-894X(01)80105-0
2487 2368 None 25 Human Binding pKi = 8.7 8.7 31 2
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
5280492 2368 None 25 Human Binding pKi = 8.7 8.7 31 2
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
CHEMBL65061 2368 None 25 Human Binding pKi = 8.7 8.7 31 2
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
DB12961 2368 None 25 Human Binding pKi = 8.7 8.7 31 2
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/jm00076a030
18963032 101146 None 0 Human Binding pKi = 8.7 8.7 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL294987 101146 None 0 Human Binding pKi = 8.7 8.7 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 444 11 2 6 4.5 CCCc1c(OCCCOc2cc(O)c(OC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
44340787 14587 None 0 Human Binding pKi = 8 8.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1204561 14587 None 0 Human Binding pKi = 8 8.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL326397 14587 None 0 Human Binding pKi = 8 8.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 435 12 3 4 6.0 CCCCCCCCC(O)c1ccc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15839729 209346 None 1 Human Binding pKi = 8.0 8.0 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15559 209346 None 1 Human Binding pKi = 8.0 8.0 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL90788 209346 None 1 Human Binding pKi = 8.0 8.0 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 456 11 2 6 4.7 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
10046307 14802 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1206771 14802 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL305560 14802 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15658110 14580 None 0 Human Binding pKi = 7 7.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113528 14580 None 0 Human Binding pKi = 7 7.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1204495 14580 None 0 Human Binding pKi = 7 7.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCCC(O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658157 14581 None 0 Human Binding pKi = 6 6.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL114454 14581 None 0 Human Binding pKi = 6 6.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL1204496 14581 None 0 Human Binding pKi = 6 6.0 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 449 12 3 5 4.9 CCCCOc1cccc(C(O)CCc2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
10037501 184830 None 4 Human Binding pKi = 4 4.0 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 245 1 1 5 0.5 CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N 10.1021/np50100a005
CHEMBL485053 184830 None 4 Human Binding pKi = 4 4.0 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 245 1 1 5 0.5 CN1C(=O)/C(=C/c2ccc3c(c2)OCO3)N=C1N 10.1021/np50100a005
18963059 14630 None 0 Human Binding pKi = 7.0 7.0 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205055 14630 None 0 Human Binding pKi = 7.0 7.0 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47726 14630 None 0 Human Binding pKi = 7.0 7.0 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 402 11 2 6 4.7 CCc1cc(OC2CCCC2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
14977959 9489 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 506 15 2 5 6.0 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112018 9489 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 506 15 2 5 6.0 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
18963030 14629 None 0 Human Binding pKi = 7.0 7.0 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205054 14629 None 0 Human Binding pKi = 7.0 7.0 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47725 14629 None 0 Human Binding pKi = 7.0 7.0 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 442 12 2 6 5.1 CCc1cc(OCc2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
21765776 163786 None 0 Human Binding pKi = 7.0 7.0 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccccc3C(=O)O)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL420488 163786 None 0 Human Binding pKi = 7.0 7.0 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccccc3C(=O)O)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
14977907 9552 None 0 Human Binding pKi = 6.0 6.0 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 483 18 2 5 6.8 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL112310 9552 None 0 Human Binding pKi = 6.0 6.0 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 483 18 2 5 6.8 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
14977965 111412 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 524 15 2 5 6.2 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL326909 111412 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 524 15 2 5 6.2 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
11798329 18512 None 0 Human Binding pKi = 7.9 7.9 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 463 8 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1 10.1021/jm960248s
CHEMBL127341 18512 None 0 Human Binding pKi = 7.9 7.9 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 463 8 1 4 6.5 O=C(O)/C=C/c1nc(CSc2c(Cl)cccc2Cl)ccc1OCc1ccc(F)cc1 10.1021/jm960248s
11800543 19398 None 0 Human Binding pKi = 7.9 7.9 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129272 19398 None 0 Human Binding pKi = 7.9 7.9 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
122023 50810 None 43 Human Binding pKi = 6.9 6.9 30 2
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL15766 50810 None 43 Human Binding pKi = 6.9 6.9 30 2
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL45460 50810 None 43 Human Binding pKi = 6.9 6.9 30 2
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
23257866 9468 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL111908 9468 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
10021742 9458 None 6 Human Binding pKi = 5.9 5.9 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
CHEMBL111825 9458 None 6 Human Binding pKi = 5.9 5.9 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/np50100a005
14977963 9645 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 574 15 2 5 7.1 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112737 9645 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 574 15 2 5 7.1 Nc1cccc([S+]([O-])Cc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
9829619 100807 None 0 Human Binding pKi = 7.9 7.9 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292783 100807 None 0 Human Binding pKi = 7.9 7.9 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranesLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in guinea pig lung membranes
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
9977200 29384 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL138370 29384 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL60617 29384 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10292143 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL336665 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL48667 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10292143 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL336665 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL48667 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
10292143 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL336665 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
CHEMBL48667 116661 None 0 Human Binding pKi = 7.9 7.9 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80454-0
18963040 14874 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1207571 14874 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL416259 14874 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15658122 9766 None 0 Human Binding pKi = 6.9 6.9 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 453 12 2 4 6.0 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113514 9766 None 0 Human Binding pKi = 6.9 6.9 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 453 12 2 4 6.0 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658098 169419 None 0 Human Binding pKi = 5.9 5.9 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 383 13 2 3 6.3 CCCCCCCCC(O)c1ccc2ccc(/C=C/CCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL441647 169419 None 0 Human Binding pKi = 5.9 5.9 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 383 13 2 3 6.3 CCCCCCCCC(O)c1ccc2ccc(/C=C/CCCC(=O)O)nc2c1 10.1021/jm00074a012
14977952 109093 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 676 19 2 7 7.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL321261 109093 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 676 19 2 7 7.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977946 110643 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 531 18 2 6 6.2 CCCCCCCCCCCCOc1ccc(CS(=O)(=O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL325423 110643 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 531 18 2 6 6.2 CCCCCCCCCCCCOc1ccc(CS(=O)(=O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
44270188 51401 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
CHEMBL15817 51401 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 484 13 1 6 5.4 CCCc1cc(OCCCOc2ccc(C(C)=O)c(OC)c2CCC)cc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80304-2
9984593 9639 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 533 17 2 5 7.3 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCCCCCc1ccccc1 10.1021/jm00046a017
CHEMBL112707 9639 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 533 17 2 5 7.3 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCCCCCc1ccccc1 10.1021/jm00046a017
15839733 45650 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15295 45650 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 458 14 2 6 5.2 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(CC)C(=O)O 10.1016/S0960-894X(00)80304-2
14977913 9263 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 5.7 COc1ccc(CCCCCCCCOc2ccc(COc3cccc(C(=O)O)c3)[n+]([O-])c2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL110797 9263 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 5.7 COc1ccc(CCCCCCCCOc2ccc(COc3cccc(C(=O)O)c3)[n+]([O-])c2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977924 111010 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL326192 111010 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10812265 58164 None 0 Human Binding pKi = 7.8 7.8 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2cccc(OC)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167923 58164 None 0 Human Binding pKi = 7.8 7.8 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2cccc(OC)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10475982 161918 None 0 Human Binding pKi = 4.8 4.8 -15 2
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL414462 161918 None 0 Human Binding pKi = 4.8 4.8 -15 2
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
21765774 9703 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL113146 9703 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
14977898 10092 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 519 15 3 6 5.3 COc1ccc(CCCCCCOc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL115437 10092 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 519 15 3 6 5.3 COc1ccc(CCCCCCOc2ccc(CC(O)c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977924 111010 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL326192 111010 None 0 Human Binding pKi = 6.8 6.8 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 17 2 6 6.2 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
10405361 14651 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205188 14651 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL62051 14651 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
15839732 45701 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15299 45701 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 444 13 2 6 4.8 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OC(C)C(=O)O 10.1016/S0960-894X(00)80304-2
44382468 59105 None 0 Human Binding pKi = 5.7 5.7 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL169639 59105 None 0 Human Binding pKi = 5.7 5.7 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44341107 9462 None 0 Human Binding pKi = 4.7 4.7 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 277 4 1 3 3.2 Cn1c(N)nc(Cc2ccccc2)c1Cc1ccccc1 10.1021/jm00074a014
CHEMBL111872 9462 None 0 Human Binding pKi = 4.7 4.7 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 277 4 1 3 3.2 Cn1c(N)nc(Cc2ccccc2)c1Cc1ccccc1 10.1021/jm00074a014
23257889 9504 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 535 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112088 9504 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 535 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
132379 111795 None 16 Human Binding pKi = 8.7 8.7 - 1
Affinity for human PMN LTB-4 receptors.Affinity for human PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
CHEMBL328712 111795 None 16 Human Binding pKi = 8.7 8.7 - 1
Affinity for human PMN LTB-4 receptors.Affinity for human PMN LTB-4 receptors.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00100a034
132379 111795 None 16 Human Binding pKi = 8.7 8.7 - 1
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00070a015
CHEMBL328712 111795 None 16 Human Binding pKi = 8.7 8.7 - 1
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00070a015
132379 111795 None 16 Human Binding pKi = 8.7 8.7 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00046a017
CHEMBL328712 111795 None 16 Human Binding pKi = 8.7 8.7 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 453 9 1 3 5.4 CN(CCc1ccccc1)C(=O)Cc1cc(C(=O)O)cc2c(OCc3ccccc3)cccc12 10.1021/jm00046a017
10694814 16577 None 0 Human Binding pKi = 8.6 8.6 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 449 12 1 5 5.9 COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL123862 16577 None 0 Human Binding pKi = 8.6 8.6 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 449 12 1 5 5.9 COc1ccc(CCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
2487 2368 None 25 Human Binding pKi = 8.5 8.5 31 2
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
5280492 2368 None 25 Human Binding pKi = 8.5 8.5 31 2
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
CHEMBL65061 2368 None 25 Human Binding pKi = 8.5 8.5 31 2
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
DB12961 2368 None 25 Human Binding pKi = 8.5 8.5 31 2
Displacement of [3H]LTB4 from LTB4RDisplacement of [3H]LTB4 from LTB4R
ChEMBL 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 10.1021/np50094a001
10182429 58156 None 0 Human Binding pKi = 7.7 7.7 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 428 10 2 5 5.7 CCc1cc(-c2ccc(Cl)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167850 58156 None 0 Human Binding pKi = 7.7 7.7 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 428 10 2 5 5.7 CCc1cc(-c2ccc(Cl)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
11800543 19398 None 0 Human Binding pKi = 7.7 7.7 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129272 19398 None 0 Human Binding pKi = 7.7 7.7 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 538 11 2 6 6.7 CCc1cc(-c2ccccc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
18963040 14874 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1207571 14874 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL416259 14874 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
18963040 14874 None 0 Human Binding pKi = 7.7 7.7 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL1207571 14874 None 0 Human Binding pKi = 7.7 7.7 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
CHEMBL416259 14874 None 0 Human Binding pKi = 7.7 7.7 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 14 2 6 5.0 CCCCCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/S0960-894X(00)80453-9
114999 3538 None 17 Human Binding pKi = 6.7 6.7 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
6156 3538 None 17 Human Binding pKi = 6.7 6.7 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
CHEMBL14823 3538 None 17 Human Binding pKi = 6.7 6.7 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1021/jm00074a014
44341141 9436 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 667 18 1 7 6.9 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(CS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL111723 9436 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 667 18 1 7 6.9 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(CS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
23257891 9707 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 551 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL113167 9707 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 551 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(OC)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10325873 9521 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL112169 9521 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 579 18 2 6 6.3 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
44382378 58886 None 0 Human Binding pKi = 6.6 6.6 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL168854 58886 None 0 Human Binding pKi = 6.6 6.6 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44341318 9551 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 349 8 2 4 3.5 Cn1c(N)nc(Cc2ccc(CCCCO)cc2)c1Cc1ccccc1 10.1021/jm00074a014
CHEMBL112309 9551 None 0 Human Binding pKi = 5.6 5.6 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 349 8 2 4 3.5 Cn1c(N)nc(Cc2ccc(CCCCO)cc2)c1Cc1ccccc1 10.1021/jm00074a014
23257882 110471 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 564 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL324478 110471 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 564 17 1 6 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10745069 30104 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 542 13 2 4 7.9 CCCc1c(Cc2ccccc2C(=O)O)cccc1OCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC 10.1021/jm00022a006
CHEMBL138954 30104 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 542 13 2 4 7.9 CCCc1c(Cc2ccccc2C(=O)O)cccc1OCCCOc1cc(O)c(-c2ccc(F)cc2)cc1CC 10.1021/jm00022a006
177941 1588 None 41 Human Binding pKi = 7.6 7.6 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
2948 1588 None 41 Human Binding pKi = 7.6 7.6 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
CHEMBL329123 1588 None 41 Human Binding pKi = 7.6 7.6 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
DB12850 1588 None 41 Human Binding pKi = 7.6 7.6 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 10.1021/jm960088k
9906324 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL1205046 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL46820 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against Guinea pig membrane LTB4 ReceptorBinding affinity against Guinea pig membrane LTB4 Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
9906324 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205046 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL46820 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
9906324 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL1205046 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
CHEMBL46820 14625 None 0 Human Binding pKi = 7.6 7.6 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80454-0
14977920 9481 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccc(C(=O)O)cc2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL111969 9481 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccc(C(=O)O)cc2)nc1/C=C/C(=O)O 10.1021/jm00074a013
44341073 10130 None 0 Human Binding pKi = 4.6 4.6 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 307 5 1 4 3.2 COc1cccc(Cc2nc(N)n(C)c2Cc2ccccc2)c1 10.1021/jm00074a014
CHEMBL115679 10130 None 0 Human Binding pKi = 4.6 4.6 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 307 5 1 4 3.2 COc1cccc(Cc2nc(N)n(C)c2Cc2ccccc2)c1 10.1021/jm00074a014
10324028 10030 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 509 15 2 6 5.6 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL115040 10030 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 509 15 2 6 5.6 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
44302963 14647 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205145 14647 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL58794 14647 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9826485 106420 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00070a015
CHEMBL313923 106420 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00070a015
114999 3538 None 17 Human Binding pKi = 6.6 6.6 - 1
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
6156 3538 None 17 Human Binding pKi = 6.6 6.6 - 1
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
CHEMBL14823 3538 None 17 Human Binding pKi = 6.6 6.6 - 1
In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayIn vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay
ChEMBL 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 10.1016/0960-894X(95)00135-G
15658099 163428 None 0 Human Binding pKi = 5.6 5.6 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 385 14 2 3 6.2 CCCCCCCCC(O)c1ccc2ccc(CCCCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL419036 163428 None 0 Human Binding pKi = 5.6 5.6 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 385 14 2 3 6.2 CCCCCCCCC(O)c1ccc2ccc(CCCCCC(=O)O)nc2c1 10.1021/jm00074a012
9826485 106420 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL313923 106420 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 469 16 3 5 5.7 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1/C=C/C(=O)O 10.1021/jm00074a013
14977927 10258 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 652 18 2 7 7.7 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL116101 10258 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 652 18 2 7 7.7 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)C(F)(F)F)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
15658155 14578 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL113288 14578 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
CHEMBL1204493 14578 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 447 11 3 5 5.0 CCCCOc1cccc(C(O)/C=C/c2cccc(CC(O)c3cccc(C(=O)O)c3)n2)c1 10.1021/jm00074a012
10179915 58124 None 0 Human Binding pKi = 8.5 8.5 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167520 58124 None 0 Human Binding pKi = 8.5 8.5 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
44302965 201410 None 0 Human Binding pKi = 8.5 8.5 - 1
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 551 14 1 7 6.5 CCCc1c(OCCCOc2ccc(-c3cscn3)c(COC)c2CC2CC2)ccc2c1O[C@@H](C(=O)O)CC2 10.1021/jm990504b
CHEMBL58495 201410 None 0 Human Binding pKi = 8.5 8.5 - 1
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 551 14 1 7 6.5 CCCc1c(OCCCOc2ccc(-c3cscn3)c(COC)c2CC2CC2)ccc2c1O[C@@H](C(=O)O)CC2 10.1021/jm990504b
192624 168594 None 0 Human Binding pKi = 8.5 8.5 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 394 10 2 5 5.1 CCc1cc(-c2ccccc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL435273 168594 None 0 Human Binding pKi = 8.5 8.5 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 394 10 2 5 5.1 CCc1cc(-c2ccccc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
9912012 162298 None 0 Human Binding pKi = 8.5 8.5 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
CHEMBL416277 162298 None 0 Human Binding pKi = 8.5 8.5 - 1
In vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assayIn vitro binding affinity using [3H]LTB4 radioligand binding to leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 458 12 2 6 4.9 CCCc1c(OCCCOc2cc(O)c(OCC)cc2CC)ccc2c1OC(C(=O)O)CC2 10.1016/S0960-894X(00)80454-0
9906324 14625 None 0 Human Binding pKi = 8.5 8.5 - 1
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL1205046 14625 None 0 Human Binding pKi = 8.5 8.5 - 1
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL46820 14625 None 0 Human Binding pKi = 8.5 8.5 - 1
Binding affinity against human neutrophil ReceptorBinding affinity against human neutrophil Receptor
ChEMBL 348 10 2 6 3.4 CCc1cc(OC)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
6157 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
6438358 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
CHEMBL422420 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Compound was tested for inhibitory activity against human neutrophil LTB4 receptor bindingCompound was tested for inhibitory activity against human neutrophil LTB4 receptor binding
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm960088k
44302966 96552 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 484 13 2 6 4.9 CCCc1c(OCCCOc2ccc3c(c2CCC)O[C@@H](C(=O)O)CC3)ccc(C(C)=O)c1CO 10.1021/jm990504b
CHEMBL262530 96552 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity to leukotriene B4 receptorBinding affinity to leukotriene B4 receptor
ChEMBL 484 13 2 6 4.9 CCCc1c(OCCCOc2ccc3c(c2CCC)O[C@@H](C(=O)O)CC3)ccc(C(C)=O)c1CO 10.1021/jm990504b
10554820 30287 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 556 13 2 5 7.5 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139115 30287 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 556 13 2 5 7.5 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1C(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
44302963 14647 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205145 14647 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL58794 14647 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 402 14 2 5 5.5 CCCCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9845585 58173 None 0 Human Binding pKi = 7.5 7.5 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccc(C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL168011 58173 None 0 Human Binding pKi = 7.5 7.5 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccc(C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
44382275 59757 None 0 Human Binding pKi = 6.5 6.5 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL172457 59757 None 0 Human Binding pKi = 6.5 6.5 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 C[C@@H](Oc1ccc2c(c1)OC[C@@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
44382384 59561 None 0 Human Binding pKi = 5.5 5.5 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL171666 59561 None 0 Human Binding pKi = 5.5 5.5 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1ccccn1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
14977911 9601 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 499 18 2 5 6.0 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)[n+]([O-])c1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL112544 9601 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 499 18 2 5 6.0 CCCCCCCCCCCCOc1ccc(COc2cccc(C(=O)O)c2)[n+]([O-])c1/C=C/C(=O)O 10.1021/jm00074a013
14977931 9658 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 520 16 2 6 7.0 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112808 9658 None 0 Human Binding pKi = 7.5 7.5 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 520 16 2 6 7.0 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10021742 9458 None 6 Human Binding pKi = 5.5 5.5 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/jm00074a014
CHEMBL111825 9458 None 6 Human Binding pKi = 5.5 5.5 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 365 4 1 7 2.6 Cn1c(N)nc(Cc2ccc3c(c2)OCO3)c1Cc1ccc2c(c1)OCO2 10.1021/jm00074a014
14977957 9522 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 490 15 2 5 7.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112176 9522 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 490 15 2 5 7.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccccc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
14977933 9892 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 552 16 2 7 5.7 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL114290 9892 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 552 16 2 7 5.7 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10507666 30926 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 592 13 2 6 7.1 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1S(=O)(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139799 30926 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 592 13 2 6 7.1 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1S(=O)(=O)c1ccccc1C(=O)O 10.1021/jm00022a006
9807782 19435 None 0 Human Binding pKi = 7.4 7.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129463 19435 None 0 Human Binding pKi = 7.4 7.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
6444688 187426 None 30 Human Binding pKi = 6.4 6.4 37 2
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00074a014
CHEMBL49302 187426 None 30 Human Binding pKi = 6.4 6.4 37 2
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1021/jm00074a014
23257894 9657 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 521 16 1 5 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112804 9657 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 521 16 1 5 6.5 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10342316 58168 None 0 Human Binding pKi = 7.4 7.4 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2ccc(OC)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167972 58168 None 0 Human Binding pKi = 7.4 7.4 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 424 11 2 6 5.1 CCc1cc(-c2ccc(OC)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10363485 59120 None 0 Human Binding pKi = 4.4 4.4 -29 2
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL169743 59120 None 0 Human Binding pKi = 4.4 4.4 -29 2
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
9800998 99422 None 2 Human Binding pKi = 4.4 4.4 -32 2
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL282524 99422 None 2 Human Binding pKi = 4.4 4.4 -32 2
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
9829619 100807 None 0 Human Binding pKi = 7.4 7.4 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
CHEMBL292783 100807 None 0 Human Binding pKi = 7.4 7.4 - 1
LTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophilLTB4 receptor antagonist activity was determined by inhibition of specific binding of [3H]LTB4 in human neutrophil
ChEMBL 574 14 3 6 7.1 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1cc(Oc2ccc(C(=O)O)cc2)ccc1CCC(=O)O 10.1016/S0960-894X(01)80105-0
44382463 59242 None 0 Human Binding pKi = 4.4 4.4 -9 2
In vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assayIn vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assay
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
CHEMBL170226 59242 None 0 Human Binding pKi = 4.4 4.4 -9 2
In vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assayIn vitro inhibitory activity was evaluated against leukotriene B4 (LTB4) in guinea pig binding assay
ChEMBL 398 5 1 5 4.5 O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 10.1016/0960-894X(95)00135-G
6157 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
6438358 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
CHEMBL422420 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Binding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligandBinding affinity against LTB4 receptors in human PMNs using [3H]LTB4 as radioligand
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00070a015
6157 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
6438358 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
CHEMBL422420 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 10.1021/jm00046a017
9807782 19435 None 0 Human Binding pKi = 8.4 8.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL129463 19435 None 0 Human Binding pKi = 8.4 8.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to guinea pig lung membranes expressing LTB4 receptor
ChEMBL 556 11 2 6 6.9 CCc1cc(-c2ccc(F)cc2)c(O)cc1OCCCOc1ccc2c(=O)c3ccccc3oc2c1CCC(=O)O 10.1021/jm00076a030
9893718 208959 None 0 Human Binding pKi = 8.4 8.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL292768 208959 None 0 Human Binding pKi = 8.4 8.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
CHEMBL88337 208959 None 0 Human Binding pKi = 8.4 8.4 - 1
Tested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptorTested for inhibition of specific binding of [3H]LTB4 to human neutrophil expressing LTB4 receptor
ChEMBL 548 12 3 8 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1CCC(=O)O 10.1021/jm00076a030
3083459 120452 None 0 Human Binding pKi = 8.3 8.3 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2cccc(F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL353378 120452 None 0 Human Binding pKi = 8.3 8.3 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 412 10 2 5 5.2 CCc1cc(-c2cccc(F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
6439436 9556 None 1 Human Binding pKi = 8.3 8.3 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112338 9556 None 1 Human Binding pKi = 8.3 8.3 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
6439436 9556 None 1 Human Binding pKi = 8.3 8.3 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL112338 9556 None 1 Human Binding pKi = 8.3 8.3 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 536 16 2 6 6.0 COc1ccc(CCCCCCCCOc2ccc(C[S+]([O-])c3cccc(N)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
10292143 116661 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL336665 116661 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL48667 116661 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 362 11 2 6 3.8 CCOc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
10050724 10126 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 477 13 2 5 5.7 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCc1ccccc1 10.1021/jm00046a017
CHEMBL115658 10126 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 477 13 2 5 5.7 O=C(O)/C=C/c1nc(CSCc2cccc(C(=O)O)c2)ccc1OCCCCc1ccccc1 10.1021/jm00046a017
15839731 49465 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
CHEMBL15648 49465 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 430 13 2 6 4.4 CCCc1c(OCCCOc2cc(O)c(C(C)=O)cc2CC)cccc1OCC(=O)O 10.1016/S0960-894X(00)80304-2
9872540 30449 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 560 13 2 5 8.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Sc1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139254 30449 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 560 13 2 5 8.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1Sc1ccccc1C(=O)O 10.1021/jm00022a006
14977894 110670 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 471 17 3 5 5.6 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1CCC(=O)O 10.1021/jm00074a013
CHEMBL325615 110670 None 0 Human Binding pKi = 6.4 6.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 471 17 3 5 5.6 CCCCCCCCCCOc1ccc(CC(O)c2cccc(C(=O)O)c2)nc1CCC(=O)O 10.1021/jm00074a013
14977961 9512 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 558 15 2 5 8.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
CHEMBL112135 9512 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 558 15 2 5 8.0 Nc1cccc(SCc2ccc(OCCCCCCCCc3ccc(C(F)(F)F)cc3)c(/C=C/C(=O)O)n2)c1 10.1021/jm00074a013
6450158 187280 None 20 Human Binding pKi = 7.4 7.4 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49210 187280 None 20 Human Binding pKi = 7.4 7.4 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
14977916 111388 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccccc2C(=O)O)nc1/C=C/C(=O)O 10.1021/jm00074a013
CHEMBL326779 111388 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 515 18 2 5 6.5 CCCCCCCCCCCCOc1ccc(C[S+]([O-])c2ccccc2C(=O)O)nc1/C=C/C(=O)O 10.1021/jm00074a013
25114442 3061 None 48 Human Binding pKi = 5.3 5.3 -1288 2
Binding assay (LTB4R )Binding assay (LTB4R )
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
5817 3061 None 48 Human Binding pKi = 5.3 5.3 -1288 2
Binding assay (LTB4R )Binding assay (LTB4R )
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
CHEMBL3286797 3061 None 48 Human Binding pKi = 5.3 5.3 -1288 2
Binding assay (LTB4R )Binding assay (LTB4R )
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
DB12024 3061 None 48 Human Binding pKi = 5.3 5.3 -1288 2
Binding assay (LTB4R )Binding assay (LTB4R )
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
25114442 3061 None 48 Human Binding pKi = 5.3 5.3 -1288 2
LTB4 (h) (BLT1) CEREP ligand profilingLTB4 (h) (BLT1) CEREP ligand profiling
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
5817 3061 None 48 Human Binding pKi = 5.3 5.3 -1288 2
LTB4 (h) (BLT1) CEREP ligand profilingLTB4 (h) (BLT1) CEREP ligand profiling
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
CHEMBL3286797 3061 None 48 Human Binding pKi = 5.3 5.3 -1288 2
LTB4 (h) (BLT1) CEREP ligand profilingLTB4 (h) (BLT1) CEREP ligand profiling
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
DB12024 3061 None 48 Human Binding pKi = 5.3 5.3 -1288 2
LTB4 (h) (BLT1) CEREP ligand profilingLTB4 (h) (BLT1) CEREP ligand profiling
ChEMBL 409 6 1 4 3.6 COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O 10.6019/CHEMBL4507298
10405361 14651 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1205188 14651 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL62051 14651 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 346 10 2 5 3.9 CCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
9977200 29384 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL138370 29384 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL60617 29384 None 0 Human Binding pKi = 8.3 8.3 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 360 11 2 5 4.3 CCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
21765772 110673 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL325637 110673 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3ccc(C(=O)O)cc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
10793277 31093 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 576 13 2 5 7.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1[S+]([O-])c1ccccc1C(=O)O 10.1021/jm00022a006
CHEMBL139969 31093 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligandBinding affinity towards LTB4 receptor guinea pig spleen cells using [3H]LTB4 as radioligand
ChEMBL 576 13 2 5 7.4 CCCc1c(OCCCOc2cc(O)c(-c3ccc(F)cc3)cc2CC)cccc1[S+]([O-])c1ccccc1C(=O)O 10.1021/jm00022a006
6450158 187280 None 20 Human Binding pKi = 8.2 8.2 - 1
Inhibition constant against binding of [3H]LTB4 to human neutrophilsInhibition constant against binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
CHEMBL49210 187280 None 20 Human Binding pKi = 8.2 8.2 - 1
Inhibition constant against binding of [3H]LTB4 to human neutrophilsInhibition constant against binding of [3H]LTB4 to human neutrophils
ChEMBL 516 12 2 6 5.9 COc1ccc(/C=C/CCCCOc2ccc3c(=O)c4cc(C(=O)O)ccc4oc3c2CCC(=O)O)cc1 10.1021/jm00064a006
15658112 63194 None 0 Human Binding pKi = 7.3 7.3 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1788228 63194 None 0 Human Binding pKi = 7.3 7.3 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL1789864 63194 None 0 Human Binding pKi = 7.3 7.3 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 419 12 2 3 6.5 CCCCCCCC[C@@H](O)c1ccc2ccc(CCc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
15658139 14582 None 0 Human Binding pKi = 6.3 6.3 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL115826 14582 None 0 Human Binding pKi = 6.3 6.3 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL1204497 14582 None 0 Human Binding pKi = 6.3 6.3 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 452 12 2 3 6.6 CCCCCCCCC(O)c1ccc2ccc(C[S+]([O-])c3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
18963028 14628 None 0 Human Binding pKi = 7.3 7.3 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1205053 14628 None 0 Human Binding pKi = 7.3 7.3 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL47716 14628 None 0 Human Binding pKi = 7.3 7.3 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 376 11 2 6 4.2 CCc1cc(OC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
44382276 120380 None 0 Human Binding pKi = 5.3 5.3 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
CHEMBL352814 120380 None 0 Human Binding pKi = 5.3 5.3 - 1
In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4)
ChEMBL 412 5 1 5 5.1 CC(Oc1ccc2c(c1)OC[C@H](Cc1cccnc1)[C@@H]2O)c1ccc2ccccc2n1 10.1016/0960-894X(95)00135-G
10371282 110676 None 0 Human Binding pKi = 7.3 7.3 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 595 18 2 7 6.0 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL325643 110676 None 0 Human Binding pKi = 7.3 7.3 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 595 18 2 7 6.0 COc1ccc(CCCCCCCCOc2ccc(CS(=O)(=O)Cc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
20704716 184831 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
CHEMBL485054 184831 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membraneDisplacement of [3H]LTB4 from LTB4 receptor expressed in human U937 cell membrane
ChEMBL 488 5 1 9 2.4 CN1C(=N)N(C)/C(=N/c2nc(Cc3ccc4c(c3)OCO4)c(Cc3ccc4c(c3)OCO4)n2C)C1=O 10.1021/np50100a005
10159791 58025 None 0 Human Binding pKi = 7.2 7.2 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccccc2C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167261 58025 None 0 Human Binding pKi = 7.2 7.2 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2ccccc2C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10046307 14802 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL1206771 14802 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
CHEMBL305560 14802 None 0 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against human neutrophil Receptor.Binding affinity against human neutrophil Receptor.
ChEMBL 374 12 2 5 4.7 CCCCc1cc(CC)c(OCCCCCC(C)(C)c2nn[nH]n2)cc1O 10.1016/0960-894X(95)00340-Y
19427041 14649 None 0 Human Binding pKi = 8.2 8.2 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL1205171 14649 None 0 Human Binding pKi = 8.2 8.2 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
CHEMBL60881 14649 None 0 Human Binding pKi = 8.2 8.2 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 534 14 3 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc(C(=O)c2cccc(C(=O)O)c2)cc1CCC(=O)O 10.1016/S0960-894X(01)80999-9
15658149 14577 None 0 Human Binding pKi = 7.2 7.2 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL111811 14577 None 0 Human Binding pKi = 7.2 7.2 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
CHEMBL1204492 14577 None 0 Human Binding pKi = 7.2 7.2 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 413 14 3 4 5.1 CCCCCCCCC(O)CCc1cccc(CC(O)c2cccc(C(=O)O)c2)n1 10.1021/jm00074a012
15658119 9813 None 0 Human Binding pKi = 6.2 6.2 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 437 12 2 4 7.0 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
CHEMBL113792 9813 None 0 Human Binding pKi = 6.2 6.2 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 437 12 2 4 7.0 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)nc2c1 10.1021/jm00074a012
14977948 9594 None 0 Human Binding pKi = 6.2 6.2 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 660 19 2 7 8.2 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112510 9594 None 0 Human Binding pKi = 6.2 6.2 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 660 19 2 7 8.2 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NS(=O)(=O)c4ccccc4)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
9845587 165724 None 0 Human Binding pKi = 7.2 7.2 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2cccc(C)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL424361 165724 None 0 Human Binding pKi = 7.2 7.2 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 408 10 2 5 5.4 CCc1cc(-c2cccc(C)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
10670634 57693 None 0 Human Binding pKi = 7.2 7.2 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 437 11 2 6 5.1 CCc1cc(-c2ccc(N(C)C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL166862 57693 None 0 Human Binding pKi = 7.2 7.2 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 437 11 2 6 5.1 CCc1cc(-c2ccc(N(C)C)cc2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
122023 50810 None 43 Human Binding pKi = 7.2 7.2 30 2
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL15766 50810 None 43 Human Binding pKi = 7.2 7.2 30 2
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
CHEMBL45460 50810 None 43 Human Binding pKi = 7.2 7.2 30 2
Binding affinity against Guinea pig membrane LTB4 Receptor.Binding affinity against Guinea pig membrane LTB4 Receptor.
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/0960-894X(95)00340-Y
10600128 58127 None 0 Human Binding pKi = 7.2 7.2 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 462 10 2 5 6.1 CCc1cc(-c2cccc(C(F)(F)F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
CHEMBL167580 58127 None 0 Human Binding pKi = 7.2 7.2 - 1
Negative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranesNegative logarithm of affinity for leukotriene B4 (LTB4) receptor on guinea pig lung membranes
ChEMBL 462 10 2 5 6.1 CCc1cc(-c2cccc(C(F)(F)F)c2)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80850-7
6435820 165111 None 4 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
CHEMBL422598 165111 None 4 Human Binding pKi = 8.2 8.2 - 1
Binding affinity against LTB4 receptors in human PMNsBinding affinity against LTB4 receptors in human PMNs
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00070a015
6435820 165111 None 4 Human Binding pKi = 8.2 8.2 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL422598 165111 None 4 Human Binding pKi = 8.2 8.2 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
6435820 165111 None 4 Human Binding pKi = 8.2 8.2 - 1
Compound was tested for binding affinity against Leukotriene B4 receptorCompound was tested for binding affinity against Leukotriene B4 receptor
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960088k
CHEMBL422598 165111 None 4 Human Binding pKi = 8.2 8.2 - 1
Compound was tested for binding affinity against Leukotriene B4 receptorCompound was tested for binding affinity against Leukotriene B4 receptor
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960088k
6435820 165111 None 4 Human Binding pKi = 8.2 8.2 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
CHEMBL422598 165111 None 4 Human Binding pKi = 8.2 8.2 - 1
Inhibition of [3H]LTB4 binding to human neutrophilsInhibition of [3H]LTB4 binding to human neutrophils
ChEMBL 563 18 2 6 7.3 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm960248s
6444688 187426 None 30 Human Binding pKi = 8.1 8.1 37 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
CHEMBL49302 187426 None 30 Human Binding pKi = 8.1 8.1 37 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 502 14 2 5 5.9 COc1ccc(/C=C/CCCCOc2ccc(C(=O)c3cccc(C(=O)O)c3)cc2CCC(=O)O)cc1 10.1016/S0960-894X(01)80999-9
6852392 17277 None 2 Human Binding pKi = 6.2 6.2 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 361 14 3 4 4.0 CCCCC/C=C\C[C@H](O)/C=C/c1cccc(C[C@H](O)CCCCO)n1 10.1021/jm00074a012
CHEMBL1256923 17277 None 2 Human Binding pKi = 6.2 6.2 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 361 14 3 4 4.0 CCCCC/C=C\C[C@H](O)/C=C/c1cccc(C[C@H](O)CCCCO)n1 10.1021/jm00074a012
14977943 115026 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 592 17 3 7 6.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NC(=O)C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL334267 115026 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 592 17 3 7 6.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(NC(=O)C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
14977939 96770 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 505 16 1 5 7.4 COc1ccc(CCCCCCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL264197 96770 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 505 16 1 5 7.4 COc1ccc(CCCCCCCCOc2ccc(CSc3ccccc3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
15839736 14646 None 0 Human Binding pKi = 6.1 6.1 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL1205143 14646 None 0 Human Binding pKi = 6.1 6.1 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
CHEMBL58534 14646 None 0 Human Binding pKi = 6.1 6.1 - 1
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 476 9 2 7 5.0 CCc1cc(C(C)=O)c(O)cc1OCCCOc1ccc2c(=O)c3cc(C(=O)O)ccc3oc2c1 10.1016/S0960-894X(01)80999-9
122023 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL15766 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
CHEMBL45460 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Compound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranesCompound was evaluated for inhibition of binding of [3H]LTB4 to LTB4 receptor in guinea-pig lung membranes
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(01)80999-9
122023 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL15766 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
CHEMBL45460 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Binding affinity against LTB4 receptor in guinea pig membraneBinding affinity against LTB4 receptor in guinea pig membrane
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80304-2
122023 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL15766 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL45460 50810 None 43 Human Binding pKi = 7.1 7.1 30 2
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 360 10 2 6 3.6 CCc1cc(C(C)=O)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
14977955 9578 None 0 Human Binding pKi = 6.1 6.1 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 548 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL112455 9578 None 0 Human Binding pKi = 6.1 6.1 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 548 17 1 6 7.5 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(N(C)C)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
10257351 110705 None 0 Human Binding pKi = 8.1 8.1 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 19 2 6 7.2 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
CHEMBL325773 110705 None 0 Human Binding pKi = 8.1 8.1 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 565 19 2 6 7.2 COc1ccc(CCCCCCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2CCC(=O)O)cc1 10.1021/jm00046a017
9959228 10077 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL115362 10077 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
9959228 10077 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
CHEMBL115362 10077 None 0 Human Binding pKi = 7.1 7.1 - 1
Binding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytesBinding affinity of [3H]LTB4 to receptors on intact human polymorphonuclear leukocytes
ChEMBL 549 17 2 6 7.1 COc1ccc(CCCCCCCCOc2ccc(CSc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00074a013
18963062 14788 None 0 Human Binding pKi = 7.1 7.1 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL1206683 14788 None 0 Human Binding pKi = 7.1 7.1 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
CHEMBL295799 14788 None 0 Human Binding pKi = 7.1 7.1 - 1
Compound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assayCompound was evaluated for receptor binding against [3H]LTB4 radioligand binding to Leukotriene B4 receptor in guinea pig lung membrane binding assay
ChEMBL 404 13 2 6 4.8 CCc1cc(OCCC(C)C)c(O)cc1OCCCCCC(C)(C)c1nn[nH]n1 10.1016/S0960-894X(00)80453-9
10346127 9680 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 507 14 2 6 5.7 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
CHEMBL112972 9680 None 0 Human Binding pKi = 8.0 8.0 - 1
Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.Binding affinity at leukotriene B4 receptor on intact human PMNs by displacement of [3H]LTB4.
ChEMBL 507 14 2 6 5.7 COc1ccc(CCCCOc2ccc(CSCc3cccc(C(=O)O)c3)nc2/C=C/C(=O)O)cc1 10.1021/jm00046a017
15658097 9737 None 0 Human Binding pKi = 6.1 6.1 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 401 14 3 4 5.2 CCCCCCCCC(O)c1ccc2ccc(CC(O)CCCC(=O)O)nc2c1 10.1021/jm00074a012
CHEMBL113351 9737 None 0 Human Binding pKi = 6.1 6.1 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 401 14 3 4 5.2 CCCCCCCCC(O)c1ccc2ccc(CC(O)CCCC(=O)O)nc2c1 10.1021/jm00074a012
44341265 10408 None 0 Human Binding pKi = 5.1 5.1 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 263 4 2 2 3.2 Nc1nc(Cc2ccccc2)c(Cc2ccccc2)[nH]1 10.1021/jm00074a014
CHEMBL116278 10408 None 0 Human Binding pKi = 5.1 5.1 - 1
Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4
ChEMBL 263 4 2 2 3.2 Nc1nc(Cc2ccccc2)c(Cc2ccccc2)[nH]1 10.1021/jm00074a014
15658135 14579 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL113401 14579 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
CHEMBL1204494 14579 None 0 Human Binding pKi = 5.1 5.1 - 1
Inhibition of [3H]- LTB4 binding on human whole cellsInhibition of [3H]- LTB4 binding on human whole cells
ChEMBL 436 12 2 3 7.6 CCCCCCCCC(O)c1ccc2ccc(CSc3cccc(C(=O)O)c3)cc2c1 10.1021/jm00074a012
None 218684 3H-LTB4 0 Human Binding pKi = 9.2 9.2 3 2
NoneNone
PDSP KiDatabase 336 14 3 3 4.2 CCCCCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O None
None 218687 3H-LTB4 0 Human Binding pKi = 6 6.0 -6 2
NoneNone
PDSP KiDatabase 318 14 1 2 5.4 CCCCCC=CCC(=O)C=CC=CCC=CCCCC(=O)O None
None 218689 3H-LTB4 0 Human Binding pKi = 6 6.0 1 2
NoneNone
PDSP KiDatabase 318 14 1 2 5.4 CCCCCC=CCC=CCC=CC=CC(=O)CCCC(=O)O None
None 218690 3H-LTB4 0 Human Binding pKi = 6 6.0 -1 2
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O None
None 218693 3H-LTB4 0 Human Binding pKi = 6 6.0 1 2
NoneNone
PDSP KiDatabase 302 12 1 1 5.7 CCCCCC=CCC=CCC=CCC#CCCCC(=O)O None
None 218686 3H-LTB4 0 Human Binding pKi = 5 5.0 -57 2
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O None
None 218690 3H-LTB4 0 Human Binding pKi = 5 5.0 -1 2
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CCC=CC=CC(CCCC(=O)O)O None
None 218691 3H-LTB4 0 Human Binding pKi = 5 5.0 -10 2
NoneNone
PDSP KiDatabase 320 15 2 2 5.2 C(CCC=CCC=CCC=CCC=CCCCC(=O)O)CCO None
None 218692 3H-LTB4 0 Human Binding pKi = 5 5.0 -10 2
NoneNone
PDSP KiDatabase 320 14 2 2 5.2 CCCCCC=CCC=CC=CC(CC=CCCCC(=O)O)O None
None 218695 3H-LTB4 0 Human Binding pKi = 5 5.0 -4365 4
NoneNone
PDSP KiDatabase 473 7 2 3 7.9 CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O None
None 218700 3H-LTB4 0 Human Binding pKi = 5 5.0 1 2
NoneNone
PDSP KiDatabase 332 13 0 3 5.3 CCCCCC=CCC=CC=CC=CC1C(O1)CCCC(=O)OC None
132191096 218694 3H-LTB4 0 Human Binding pKi = 5.8 5.8 -1 2
NoneNone
PDSP KiDatabase 352 14 4 4 3.1 CCCCCC(C=CC=CC=CC=CC(C(CCCC(=O)O)O)O)O None
None 218696 3H-LTB4 0 Human Binding pKi = 5.7 5.7 4 2
NoneNone
PDSP KiDatabase 625 25 7 8 2.8 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N None
None 218698 3H-LTB4 0 Human Binding pKi = 5.6 5.6 2 2
NoneNone
PDSP KiDatabase 439 18 4 5 4.3 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)N None
None 218688 3H-LTB4 0 Human Binding pKi = 7.6 7.6 218 2
NoneNone
PDSP KiDatabase 361 14 3 4 4.0 CCCCCC=CCC(C=CC1=NC(=CC=C1)CC(CCCCO)O)O None
None 218685 3H-LTB4 0 Human Binding pKi = 8.4 8.4 2 2
NoneNone
PDSP KiDatabase 334 13 3 3 3.9 CCC=CCC=CCC(C=CC=CC=CC(CCCC(=O)O)O)O None
None 218697 3H-LTB4 0 Human Binding pKi = 5.4 5.4 2 2
NoneNone
PDSP KiDatabase 496 20 5 6 3.4 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N None
None 218699 3H-LTB4 0 Human Binding pKi = 5.2 5.2 1 2
NoneNone
PDSP KiDatabase 568 23 6 7 3.7 CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)O)NC(=O)CCC(C(=O)O)N None
2855 4132 3H-LTB4 63 Human Binding pKi = 5.2 5.2 -147 6
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3322 4132 3H-LTB4 63 Human Binding pKi = 5.2 5.2 -147 6
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717 4132 3H-LTB4 63 Human Binding pKi = 5.2 5.2 -147 6
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717.0 4132 3H-LTB4 63 Human Binding pKi = 5.2 5.2 -147 6
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
CHEMBL603 4132 3H-LTB4 63 Human Binding pKi = 5.2 5.2 -147 6
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
DB00549 4132 3H-LTB4 63 Human Binding pKi = 5.2 5.2 -147 6
NoneNone
PDSP KiDatabase 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3325 3904 None 0 Human Binding pKi = 6.4 6.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 361 14 3 4 4.0 CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O 10513580
6449854 3904 None 0 Human Binding pKi = 6.4 6.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 361 14 3 4 4.0 CCCCC/C=C\C[C@H](/C=C/c1cccc(n1)C[C@H](CCCCO)O)O 10513580
3351 2402 None 0 Human Binding pKi = 6.6 6.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 1659282
35025716 2402 None 0 Human Binding pKi = 6.6 6.6 - 1
UnclassifiedUnclassified
Guide to Pharmacology 360 10 2 6 3.6 CCc1c(OCCCCCC(c2nnn[nH]2)(C)C)cc(cc1C(=O)C)O 1659282
3405 11 None 0 Human Binding pKi = 7.5 7.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
5283156 11 None 0 Human Binding pKi = 7.5 7.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
CHEMBL1435825 11 None 0 Human Binding pKi = 7.5 7.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology 320 14 2 2 5.2 CCCCC/C=C\C[C@H](/C=C/C=C\C/C=C\CCCC(=O)O)O 9177352
177941 1588 None 41 Human Binding pKi = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
2948 1588 None 41 Human Binding pKi = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
CHEMBL329123 1588 None 41 Human Binding pKi = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
DB12850 1588 None 41 Human Binding pKi = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 544 13 2 5 8.1 CCCc1c(OCCCOc2cc(O)c(cc2CC)c2ccc(cc2)F)cccc1Oc1ccccc1C(=O)O 9862783
114999 3538 None 17 Human Binding pKi = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
6156 3538 None 17 Human Binding pKi = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
CHEMBL14823 3538 None 17 Human Binding pKi = 7.8 7.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 484 13 1 6 5.4 CCCc1c(OCCCOc2ccc(c(c2CCC)OC)C(=O)C)ccc2c1OC(CC2)C(=O)O 7786309
3399 41 None 0 Human Binding pKi = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
5280745 41 None 0 Human Binding pKi = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
CHEMBL1593789 41 None 0 Human Binding pKi = 8.1 8.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology 352 15 4 4 3.1 OCCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O 9177352
6155 1176 None 0 Human Binding pKi = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
9823886 1176 None 0 Human Binding pKi = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
CHEMBL301829 1176 None 0 Human Binding pKi = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
DB13053 1176 None 0 Human Binding pKi = 8.2 8.2 - 1
UnclassifiedUnclassified
Guide to Pharmacology 428 4 2 3 5.4 O[C@@H]1[C@H](COc2c1ccc(c2)c1cc(ccc1C(=O)O)C(F)(F)F)Cc1ccccc1 9618393
6157 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6438358 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
CHEMBL422420 2934 None 20 Human Binding pKi = 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology 470 17 2 5 5.6 COc1ccc(cc1)/C=C/CCCCOc1cccc(c1CCC(=O)O)OCCCCC(=O)O 1332129
6154 634 None 0 Human Binding pKi = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
6154 634 None 0 Human Binding pKi = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
9956189 634 None 0 Human Binding pKi = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 11259574
9956189 634 None 0 Human Binding pKi = 8.8 8.8 - 1
UnclassifiedUnclassified
Guide to Pharmacology 466 9 3 4 6.2 Oc1ccc(cc1)C(c1ccc(cc1)OCc1cccc(c1)COc1ccc(cc1)C(=N)N)(C)C 17170051
2487 2368 None 25 Human Binding pKi = 9.4 9.4 31 2
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
5280492 2368 None 25 Human Binding pKi = 9.4 9.4 31 2
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
CHEMBL65061 2368 None 25 Human Binding pKi = 9.4 9.4 31 2
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
DB12961 2368 None 25 Human Binding pKi = 9.4 9.4 31 2
UnclassifiedUnclassified
Guide to Pharmacology 336 14 3 3 4.2 CCCCC/C=C\C[C@H](/C=C/C=C/C=C\[C@H](CCCC(=O)O)O)O None
2855 4132 None 63 Human Binding pKi None 8.3 8.3 -147 6
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
3322 4132 None 63 Human Binding pKi None 8.3 8.3 -147 6
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717 4132 None 63 Human Binding pKi None 8.3 8.3 -147 6
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
5717.0 4132 None 63 Human Binding pKi None 8.3 8.3 -147 6
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
CHEMBL603 4132 None 63 Human Binding pKi None 8.3 8.3 -147 6
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None
DB00549 4132 None 63 Human Binding pKi None 8.3 8.3 -147 6
NoneNone
Drug Central 575 8 2 7 5.7 COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C None