Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 5280878 | 100327 | None | 24 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL288943 | 100327 | None | 24 | Human | Functional | pEC50 | = | 9.1 | 9.1 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/acs.jmedchem.1c01078 | |||
| 3352 | 2371 | None | 24 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -575 | 4 | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | |||
| 5280879 | 2371 | None | 24 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -575 | 4 | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | |||
| 5863 | 2371 | None | 24 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -575 | 4 | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL509456 | 2371 | None | 24 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -575 | 4 | ChEMBL | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | |||
| 49863644 | 15319 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 498 | 13 | 1 | 5 | 6.1 | O=C(O)COc1ccc(F)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213847 | 15319 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 498 | 13 | 1 | 5 | 6.1 | O=C(O)COc1ccc(F)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 49863643 | 15318 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 480 | 13 | 1 | 5 | 5.9 | O=C(O)COc1ccccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213846 | 15318 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 480 | 13 | 1 | 5 | 5.9 | O=C(O)COc1ccccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 49863685 | 15323 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 471 | 13 | 1 | 6 | 5.4 | N#CCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccccc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213918 | 15323 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 471 | 13 | 1 | 6 | 5.4 | N#CCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1ccc(OCCCCOc2ccccc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 3354 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -74 | 4 | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | |||
| 5280493 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -74 | 4 | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL451509 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -74 | 4 | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | |||
| DB08855 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -74 | 4 | ChEMBL | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10.1021/acs.jmedchem.1c01078 | |||
| 46919026 | 15322 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 505 | 13 | 1 | 6 | 6.1 | N#CCOc1cc(C(=O)O)ccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213917 | 15322 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 505 | 13 | 1 | 6 | 6.1 | N#CCOc1cc(C(=O)O)ccc1C(=O)/C=C/c1ccc(OCCCCOc2ccc(Cl)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 1836 | 2592 | None | 44 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | |||
| 3340 | 2592 | None | 44 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | |||
| 5281040 | 2592 | None | 44 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | |||
| 5281040.0 | 2592 | None | 44 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | |||
| DB00471 | 2592 | None | 44 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/j.bmc.2010.06.047 | |||
| 9829145 | 119391 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL344180 | 119391 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 44360643 | 30896 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL139757 | 30896 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 122183753 | 122280 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 3 | 2 | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597618 | 122280 | None | 0 | Human | Functional | pIC50 | = | 9.7 | 9.7 | 3 | 2 | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 2855 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | |||
| 3322 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | |||
| 5717 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | |||
| 5717.0 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | |||
| DB00549 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.1c01078 | |||
| 122183752 | 122279 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 17 | 2 | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597617 | 122279 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | 17 | 2 | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 44360674 | 118635 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL341603 | 118635 | None | 0 | Human | Functional | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/j.bmc.2010.06.047 | |||
| 122183751 | 122278 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 1 | 2 | ChEMBL | 543 | 10 | 2 | 4 | 6.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597616 | 122278 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 1 | 2 | ChEMBL | 543 | 10 | 2 | 4 | 6.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 15291446 | 35203 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL143515 | 35203 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 44360585 | 119156 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL342705 | 119156 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | - | 1 | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/j.bmc.2010.06.047 | |||
| 66739117 | 122260 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 9 | 2 | ChEMBL | 573 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597535 | 122260 | None | 0 | Human | Functional | pIC50 | = | 9.3 | 9.3 | 9 | 2 | ChEMBL | 573 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 11261220 | 117982 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 5 | 2 | ChEMBL | 539 | 13 | 2 | 7 | 5.6 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3403186 | 117982 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 5 | 2 | ChEMBL | 539 | 13 | 2 | 7 | 5.6 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 122183684 | 122252 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 7 | 2 | ChEMBL | 559 | 14 | 2 | 4 | 7.7 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597527 | 122252 | None | 0 | Human | Functional | pIC50 | = | 9.2 | 9.2 | 7 | 2 | ChEMBL | 559 | 14 | 2 | 4 | 7.7 | Cc1c(Cl)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 122183758 | 122286 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 19 | 2 | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597623 | 122286 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 19 | 2 | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 11398820 | 117851 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -1 | 2 | ChEMBL | 556 | 13 | 3 | 8 | 4.7 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3401689 | 117851 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -1 | 2 | ChEMBL | 556 | 13 | 3 | 8 | 4.7 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 2237 | 3162 | None | 53 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | |||
| 3634 | 3162 | None | 53 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | |||
| 4887 | 3162 | None | 53 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | |||
| 4887.0 | 3162 | None | 53 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | |||
| DB01411 | 3162 | None | 53 | Human | Functional | pIC50 | = | 9.1 | 9.1 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/j.bmc.2010.06.047 | |||
| 122183689 | 122257 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4cc(F)c(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597532 | 122257 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | 1 | 2 | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4cc(F)c(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 44360637 | 118624 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 571 | 15 | 2 | 4 | 8.8 | CCCCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL341547 | 118624 | None | 0 | Human | Functional | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 571 | 15 | 2 | 4 | 8.8 | CCCCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C | 10.1016/j.bmc.2010.06.047 | |||
| 122183682 | 122250 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | 2 | 2 | ChEMBL | 565 | 14 | 2 | 4 | 7.1 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597525 | 122250 | None | 0 | Human | Functional | pIC50 | = | 9 | 9.0 | 2 | 2 | ChEMBL | 565 | 14 | 2 | 4 | 7.1 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | |||
| 122183690 | 122259 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 6 | 2 | ChEMBL | 557 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597534 | 122259 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 6 | 2 | ChEMBL | 557 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 46835000 | 122296 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 1 | 3 | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597633 | 122296 | None | 0 | Human | Functional | pIC50 | = | 9.0 | 9.0 | 1 | 3 | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 23124563 | 115088 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 630 | 2 | ChEMBL | 546 | 12 | 3 | 6 | 4.4 | O=C(O)CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342952 | 115088 | None | 0 | Human | Functional | pIC50 | = | 8.9 | 8.9 | 630 | 2 | ChEMBL | 546 | 12 | 3 | 6 | 4.4 | O=C(O)CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 44352406 | 21521 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL131611 | 21521 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 11713438 | 122247 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 3 | 2 | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597522 | 122247 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 3 | 2 | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | |||
| 46834997 | 122287 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 1 | 3 | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597624 | 122287 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 1 | 3 | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 87131159 | 122258 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 1 | 2 | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597533 | 122258 | None | 0 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 1 | 2 | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 46830962 | 122297 | None | 24 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 3 | 3 | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597634 | 122297 | None | 24 | Human | Functional | pIC50 | = | 8.8 | 8.8 | 3 | 3 | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 122183755 | 122283 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | 7 | 2 | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597620 | 122283 | None | 0 | Human | Functional | pIC50 | = | 8 | 8.0 | 7 | 2 | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 10839186 | 119771 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL34740 | 119771 | None | 0 | Human | Functional | pIC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 10766366 | 13333 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11921 | 13333 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| 10646529 | 10394 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 435 | 6 | 2 | 4 | 6.0 | Cc1cc(C(=O)O)c(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11625 | 10394 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | - | 1 | ChEMBL | 435 | 6 | 2 | 4 | 6.0 | Cc1cc(C(=O)O)c(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 49863895 | 15371 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 448 | 7 | 3 | 5 | 5.1 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2ccc(OCc3nc4ccccc4[nH]3)cc2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214416 | 15371 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | - | 1 | ChEMBL | 448 | 7 | 3 | 5 | 5.1 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2ccc(OCc3nc4ccccc4[nH]3)cc2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| 9890153 | 162613 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL416769 | 162613 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 122183763 | 122293 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 4 | 2 | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2c(F)ccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597630 | 122293 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | 4 | 2 | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2c(F)ccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 11191817 | 115091 | None | 2 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -3 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 11191817 | 115091 | None | 2 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -3 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342955 | 115091 | None | 2 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -3 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3342955 | 115091 | None | 2 | Human | Functional | pIC50 | = | 8.0 | 8.0 | -3 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 5059 | 208819 | None | 32 | Human | Functional | pIC50 | = | 6.0 | 6.0 | 2 | 3 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL8747 | 208819 | None | 32 | Human | Functional | pIC50 | = | 6.0 | 6.0 | 2 | 3 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| 10764782 | 162834 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL417135 | 162834 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 5059 | 208819 | None | 32 | Human | Functional | pIC50 | = | 6.0 | 6.0 | 2 | 3 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL8747 | 208819 | None | 32 | Human | Functional | pIC50 | = | 6.0 | 6.0 | 2 | 3 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| 11626955 | 151900 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -18 | 2 | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3965244 | 151900 | None | 0 | Human | Functional | pIC50 | = | 7.0 | 7.0 | -18 | 2 | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 127043617 | 140476 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c2c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3808608 | 140476 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c2c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 10792471 | 116771 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL33729 | 116771 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 11853184 | 117986 | None | 3 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 2 | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3403190 | 117986 | None | 3 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 2 | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | |||
| 122183754 | 122281 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 7 | 2 | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597619 | 122281 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 7 | 2 | ChEMBL | 557 | 11 | 2 | 4 | 6.8 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 23124629 | 115090 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 74 | 2 | ChEMBL | 574 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342954 | 115090 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 74 | 2 | ChEMBL | 574 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 127043233 | 140567 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 508 | 7 | 2 | 4 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3809628 | 140567 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 508 | 7 | 2 | 4 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 11307317 | 115095 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -194 | 2 | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342959 | 115095 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -194 | 2 | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 14650410 | 190308 | None | 13 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 6 | 2 | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL5174405 | 190308 | None | 13 | Human | Functional | pIC50 | = | 5.9 | 5.9 | 6 | 2 | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| 44352282 | 118517 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL341172 | 118517 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 10765224 | 119874 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL34835 | 119874 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 118716774 | 115086 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 281 | 2 | ChEMBL | 488 | 9 | 2 | 5 | 4.5 | CC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342950 | 115086 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 281 | 2 | ChEMBL | 488 | 9 | 2 | 5 | 4.5 | CC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 11853184 | 117986 | None | 3 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 2 | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3403190 | 117986 | None | 3 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 2 | 2 | ChEMBL | 527 | 15 | 2 | 5 | 6.5 | O=C(O)CCCn1cc(CC(=O)O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 49863972 | 15399 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | C[C@@H](C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214642 | 15399 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | C[C@@H](C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 23124775 | 115093 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 560 | 15 | 3 | 6 | 5.6 | O=C(O)CCCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342957 | 115093 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 560 | 15 | 3 | 6 | 5.6 | O=C(O)CCCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 23124623 | 115094 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -19 | 2 | ChEMBL | 518 | 12 | 3 | 6 | 4.5 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342958 | 115094 | None | 0 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -19 | 2 | ChEMBL | 518 | 12 | 3 | 6 | 4.5 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 59599515 | 148235 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 10 | 2 | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2ccc(Oc3ccc(C(=O)O)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3935529 | 148235 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | 10 | 2 | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2ccc(Oc3ccc(C(=O)O)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 2855 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | |||
| 3322 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | |||
| 5717 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | |||
| 5717.0 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | |||
| DB00549 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.9 | 7.9 | 1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acsmedchemlett.5b00482 | |||
| 135430849 | 13036 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 449 | 7 | 2 | 7 | 4.6 | O=C(/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1)c1cc(-c2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11899 | 13036 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 449 | 7 | 2 | 7 | 4.6 | O=C(/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1)c1cc(-c2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | |||
| 49863945 | 15393 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 479 | 7 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2CO)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214582 | 15393 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 479 | 7 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2CO)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 10764001 | 10033 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11509 | 10033 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 11690196 | 142853 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -4 | 2 | ChEMBL | 416 | 7 | 2 | 7 | 4.5 | CC(=O)c1ccc(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3892611 | 142853 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -4 | 2 | ChEMBL | 416 | 7 | 2 | 7 | 4.5 | CC(=O)c1ccc(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 59599580 | 152805 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -8 | 2 | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3973048 | 152805 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -8 | 2 | ChEMBL | 471 | 7 | 2 | 8 | 4.6 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(C(F)(F)F)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 49863766 | 15345 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 645 | 11 | 2 | 7 | 6.1 | COc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214096 | 15345 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 645 | 11 | 2 | 7 | 6.1 | COc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 118716775 | 115087 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 34 | 2 | ChEMBL | 502 | 10 | 2 | 5 | 4.9 | CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342951 | 115087 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | 34 | 2 | ChEMBL | 502 | 10 | 2 | 5 | 4.9 | CCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 59599475 | 149246 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -1 | 2 | ChEMBL | 421 | 7 | 2 | 8 | 3.7 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(F)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3943547 | 149246 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | -1 | 2 | ChEMBL | 421 | 7 | 2 | 8 | 3.7 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(F)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 127043243 | 140554 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2c(Cl)cccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3809483 | 140554 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2c(Cl)cccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 122183762 | 122292 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cc(F)cc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597629 | 122292 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cc(F)cc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 49863872 | 15360 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 480 | 7 | 2 | 6 | 4.5 | O=C(O)c1cc(=O)c2cccc(C(=O)NCc3ccc(OCc4ccc5ccccc5n4)cc3)c2o1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214353 | 15360 | None | 0 | Human | Functional | pIC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 480 | 7 | 2 | 6 | 4.5 | O=C(O)c1cc(=O)c2cccc(C(=O)NCc3ccc(OCc4ccc5ccccc5n4)cc3)c2o1 | 10.1016/j.bmc.2010.06.047 | |||
| 127043241 | 140562 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(Cl)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3809556 | 140562 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(Cl)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 10767627 | 109162 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL32136 | 109162 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 10574284 | 117037 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL33871 | 117037 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 122183756 | 122284 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597621 | 122284 | None | 0 | Human | Functional | pIC50 | = | 7.8 | 7.8 | 1 | 2 | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 11398475 | 115100 | None | 4 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -19 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342964 | 115100 | None | 4 | Human | Functional | pIC50 | = | 7.8 | 7.8 | -19 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 10790119 | 11170 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)c(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11785 | 11170 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 459 | 7 | 2 | 5 | 5.8 | O=C(O)c1cc(Cl)c(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 10787157 | 114172 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL33276 | 114172 | None | 0 | Human | Functional | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 15291450 | 168463 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 501 | 12 | 2 | 4 | 7.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccccn2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL434445 | 168463 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 501 | 12 | 2 | 4 | 7.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccccn2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 118728613 | 117854 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 2 | 2 | ChEMBL | 488 | 12 | 2 | 5 | 5.4 | O=C(O)CCCN1CCOc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3401692 | 117854 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | 2 | 2 | ChEMBL | 488 | 12 | 2 | 5 | 5.4 | O=C(O)CCCN1CCOc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 49863907 | 15377 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 658 | 9 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214477 | 15377 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 658 | 9 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | |||
| 46835000 | 122296 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597633 | 122296 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 583 | 14 | 2 | 4 | 7.5 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 46834997 | 122287 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597624 | 122287 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 122183688 | 122256 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 2 | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)c(F)cc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597531 | 122256 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 2 | ChEMBL | 597 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)c(F)cc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 58725448 | 192344 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 583 | 11 | 1 | 3 | 10.0 | CC(C)(C)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL5205127 | 192344 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 583 | 11 | 1 | 3 | 10.0 | CC(C)(C)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| 15291441 | 118651 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 557 | 15 | 2 | 4 | 8.5 | CCCCc1cccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL341657 | 118651 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 557 | 15 | 2 | 4 | 8.5 | CCCCc1cccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/j.bmc.2010.06.047 | |||
| 122183687 | 122255 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -2 | 2 | ChEMBL | 579 | 14 | 2 | 4 | 7.4 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597530 | 122255 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -2 | 2 | ChEMBL | 579 | 14 | 2 | 4 | 7.4 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4c(F)ccc(F)c4F)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 46830677 | 122294 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.6 | 8.6 | 1 | 3 | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597631 | 122294 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.6 | 8.6 | 1 | 3 | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 9804436 | 20646 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL130846 | 20646 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 15291439 | 119519 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 543 | 13 | 2 | 4 | 8.0 | CCc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL345093 | 119519 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 543 | 13 | 2 | 4 | 8.0 | CCc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C | 10.1016/j.bmc.2010.06.047 | |||
| 46830677 | 122294 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -1 | 3 | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597631 | 122294 | None | 0 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -1 | 3 | ChEMBL | 623 | 14 | 2 | 4 | 7.6 | Cc1c(CCCC(=O)O)c2cccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 122183683 | 122251 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 4 | 2 | ChEMBL | 543 | 14 | 2 | 4 | 7.2 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597526 | 122251 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 4 | 2 | ChEMBL | 543 | 14 | 2 | 4 | 7.2 | Cc1c(F)cccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)cn(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 59599565 | 145403 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 2 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3913281 | 145403 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 2 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 159289 | 102120 | None | 17 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | |||
| CHEMBL302045 | 102120 | None | 17 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | |||
| 59599568 | 146138 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3918914 | 146138 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | 1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 10649046 | 9762 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 499 | 6 | 2 | 4 | 6.5 | O=C(O)c1cc(Br)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11349 | 9762 | None | 0 | Human | Functional | pIC50 | = | 6.7 | 6.7 | - | 1 | ChEMBL | 499 | 6 | 2 | 4 | 6.5 | O=C(O)c1cc(Br)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| 44352288 | 117411 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL339716 | 117411 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 28775506 | 190750 | None | 6 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL5181326 | 190750 | None | 6 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 265 | 4 | 1 | 3 | 3.3 | OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/acs.jmedchem.1c01078 | |||
| 49863608 | 15314 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 517 | 7 | 2 | 5 | 6.2 | Cc1cc(COc2ccc(/C=C/C(=O)c3cc(Br)cc(C(=O)O)c3O)cc2)nc2ccccc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213780 | 15314 | None | 0 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 517 | 7 | 2 | 5 | 6.2 | Cc1cc(COc2ccc(/C=C/C(=O)c3cc(Br)cc(C(=O)O)c3O)cc2)nc2ccccc12 | 10.1016/j.bmc.2010.06.047 | |||
| 127043242 | 140537 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 3981 | 2 | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)ccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3809333 | 140537 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 3981 | 2 | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)ccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 11227280 | 117852 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 609 | 14 | 3 | 8 | 3.8 | CS(=O)(=O)NC(=O)C1CN(CCCC(=O)O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3401690 | 117852 | None | 0 | Human | Functional | pIC50 | = | 7.7 | 7.7 | -1 | 2 | ChEMBL | 609 | 14 | 3 | 8 | 3.8 | CS(=O)(=O)NC(=O)C1CN(CCCC(=O)O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2O1 | 10.1016/j.bmc.2015.03.011 | |||
| 159289 | 102120 | None | 17 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | |||
| CHEMBL302045 | 102120 | None | 17 | Human | Functional | pIC50 | = | 5.7 | 5.7 | - | 1 | ChEMBL | 333 | 5 | 2 | 7 | 2.5 | COc1ccc2sc(C(=O)Nc3nnn[nH]3)c(OC(C)C)c2c1 | 10.1021/jm00083a023 | |||
| 2237 | 3162 | None | 53 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | |||
| 3634 | 3162 | None | 53 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | |||
| 4887 | 3162 | None | 53 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | |||
| 4887.0 | 3162 | None | 53 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | |||
| DB01411 | 3162 | None | 53 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acsmedchemlett.5b00482 | |||
| 128355 | 3669 | None | 19 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1 | 3 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | |||
| 3329 | 3669 | None | 19 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1 | 3 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | |||
| CHEMBL18132 | 3669 | None | 19 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1 | 3 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm960088k | |||
| 11455387 | 117983 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -77 | 2 | ChEMBL | 531 | 14 | 2 | 6 | 5.6 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3403187 | 117983 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | -77 | 2 | ChEMBL | 531 | 14 | 2 | 6 | 5.6 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 11596869 | 143724 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 8 | 2 | ChEMBL | 417 | 7 | 2 | 8 | 3.9 | CC(=O)c1ccc(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3899832 | 143724 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 8 | 2 | ChEMBL | 417 | 7 | 2 | 8 | 3.9 | CC(=O)c1ccc(OCc2ccc(Oc3cc(-c4nn[nH]n4)ccn3)cc2)c(C)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 127043248 | 140477 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1819 | 2 | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2[nH]c(C(=O)O)c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c2c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3808613 | 140477 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 1819 | 2 | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1ccc2[nH]c(C(=O)O)c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c2c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 122183760 | 122289 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 2 | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597626 | 122289 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | 2 | 2 | ChEMBL | 599 | 14 | 2 | 4 | 8.0 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 44360895 | 34815 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 597 | 13 | 2 | 4 | 8.7 | CCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C(F)(F)F | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL143115 | 34815 | None | 0 | Human | Functional | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 597 | 13 | 2 | 4 | 8.7 | CCc1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)ccc1C(F)(F)F | 10.1016/j.bmc.2010.06.047 | |||
| 118729614 | 117984 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 1 | 2 | ChEMBL | 541 | 14 | 2 | 6 | 6.0 | O=C(O)CCCn1cc(C(=O)O)c(=O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3403188 | 117984 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | 1 | 2 | ChEMBL | 541 | 14 | 2 | 6 | 6.0 | O=C(O)CCCn1cc(C(=O)O)c(=O)c2c(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 10502162 | 111534 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL32764 | 111534 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 14774173 | 189990 | None | 6 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 1 | 2 | ChEMBL | 279 | 4 | 1 | 3 | 3.5 | O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL5169385 | 189990 | None | 6 | Human | Functional | pIC50 | = | 5.6 | 5.6 | 1 | 2 | ChEMBL | 279 | 4 | 1 | 3 | 3.5 | O=C(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| 127043049 | 140496 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 561 | 6 | 3 | 3 | 8.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3808880 | 140496 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 561 | 6 | 3 | 3 | 8.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 23124716 | 115097 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -18 | 2 | ChEMBL | 534 | 13 | 3 | 7 | 4.3 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342961 | 115097 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -18 | 2 | ChEMBL | 534 | 13 | 3 | 7 | 4.3 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 46830961 | 122291 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.5 | 8.5 | 1 | 3 | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597628 | 122291 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.5 | 8.5 | 1 | 3 | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 122183681 | 122249 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 7 | 2 | ChEMBL | 545 | 14 | 2 | 4 | 7.4 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4cccc(Cl)c4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597524 | 122249 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 7 | 2 | ChEMBL | 545 | 14 | 2 | 4 | 7.4 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4cccc(Cl)c4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | |||
| 10074704 | 165400 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL423333 | 165400 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 68695885 | 122248 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 7 | 2 | ChEMBL | 511 | 14 | 2 | 4 | 6.7 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597523 | 122248 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | 7 | 2 | ChEMBL | 511 | 14 | 2 | 4 | 6.7 | O=C(O)CCCc1cn(CC(=O)O)c2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc12 | 10.1021/acs.jmedchem.5b00741 | |||
| 46830961 | 122291 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 3 | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597628 | 122291 | None | 0 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -1 | 3 | ChEMBL | 617 | 14 | 2 | 4 | 8.1 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 44352452 | 18955 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL128641 | 18955 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 44352450 | 19486 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL129866 | 19486 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 10576732 | 10245 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 481 | 11 | 1 | 5 | 6.6 | CCCCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11609 | 10245 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 481 | 11 | 1 | 5 | 6.6 | CCCCOc1ccc(C(=O)O)cc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 118716776 | 114896 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 12 | 2 | ChEMBL | 516 | 11 | 2 | 5 | 5.3 | CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3341770 | 114896 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 12 | 2 | ChEMBL | 516 | 11 | 2 | 5 | 5.3 | CCCC(=O)N1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 23124741 | 115096 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1 | 2 | ChEMBL | 520 | 12 | 3 | 7 | 3.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342960 | 115096 | None | 0 | Human | Functional | pIC50 | = | 5.5 | 5.5 | -1 | 2 | ChEMBL | 520 | 12 | 3 | 7 | 3.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 10597634 | 10528 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11687 | 10528 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 409 | 7 | 1 | 4 | 5.4 | O=C(O)c1ccccc1C(=O)/C=C/c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 10553494 | 109177 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL32138 | 109177 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 1836 | 2592 | None | 44 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | |||
| 3340 | 2592 | None | 44 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | |||
| 5281040 | 2592 | None | 44 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | |||
| 5281040.0 | 2592 | None | 44 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | |||
| DB00471 | 2592 | None | 44 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -10 | 20 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acsmedchemlett.5b00482 | |||
| 127043048 | 140602 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 532 | 6 | 1 | 3 | 8.6 | O=C(/C=C/c1c[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3810142 | 140602 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 532 | 6 | 1 | 3 | 8.6 | O=C(/C=C/c1c[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 11284237 | 115098 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -1 | 2 | ChEMBL | 548 | 14 | 3 | 7 | 4.7 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342962 | 115098 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -1 | 2 | ChEMBL | 548 | 14 | 3 | 7 | 4.7 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCOc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 59599459 | 149517 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3945882 | 149517 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ncccc3-c3nn[nH]n3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 49863609 | 15316 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 376 | 7 | 2 | 4 | 4.6 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCC3=CCCC=C3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213782 | 15316 | None | 0 | Human | Functional | pIC50 | = | 4.5 | 4.5 | - | 1 | ChEMBL | 376 | 7 | 2 | 4 | 4.6 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCC3=CCCC=C3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 59599545 | 147247 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -3 | 2 | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3927834 | 147247 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -3 | 2 | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 10597232 | 11317 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 402 | 5 | 1 | 4 | 5.9 | N#Cc1ccc(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11793 | 11317 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 402 | 5 | 1 | 4 | 5.9 | N#Cc1ccc(O)c(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 59599538 | 145133 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ccc(-c4nn[nH]n4)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3911282 | 145133 | None | 0 | Human | Functional | pIC50 | = | 6.5 | 6.5 | 1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3ccc(-c4nn[nH]n4)cn3)cc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 127043236 | 140519 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 660 | 2 | ChEMBL | 467 | 5 | 3 | 3 | 6.5 | O=C(O)c1[nH]c2ccccc2c1C(=O)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3809164 | 140519 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 660 | 2 | ChEMBL | 467 | 5 | 3 | 3 | 6.5 | O=C(O)c1[nH]c2ccccc2c1C(=O)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 11353238 | 117981 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -2 | 2 | ChEMBL | 541 | 14 | 2 | 7 | 5.2 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3403185 | 117981 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | -2 | 2 | ChEMBL | 541 | 14 | 2 | 7 | 5.2 | O=C(O)CCCN1CC(c2nnn[nH]2)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 49863809 | 15358 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1cccc(CC(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214219 | 15358 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1cccc(CC(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 127043247 | 140504 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 1995 | 2 | ChEMBL | 529 | 6 | 3 | 3 | 7.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(F)cc(F)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3808968 | 140504 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 1995 | 2 | ChEMBL | 529 | 6 | 3 | 3 | 7.2 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(F)cc(F)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 10324292 | 15324 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213919 | 15324 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 44352484 | 21495 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL131582 | 21495 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 10651746 | 99945 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL285994 | 99945 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 59599555 | 153637 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3980125 | 153637 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3ncccc3-c3nn[nH]n3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 13626863 | 190231 | None | 5 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 293 | 4 | 0 | 4 | 3.6 | COC(=O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL5173307 | 190231 | None | 5 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 293 | 4 | 0 | 4 | 3.6 | COC(=O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| 49863922 | 15384 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 630 | 9 | 2 | 7 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214531 | 15384 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 630 | 9 | 2 | 7 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(OCc3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | |||
| 49863921 | 15383 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | C[C@@H](Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214530 | 15383 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | C[C@@H](Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 122183685 | 122253 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 525 | 14 | 2 | 4 | 7.0 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597528 | 122253 | None | 0 | Human | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 2 | ChEMBL | 525 | 14 | 2 | 4 | 7.0 | Cc1c(CCCC(=O)O)c2cccc(/C=C/c3ccc(OCCCCc4ccccc4)cc3)c2n1CC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 46830963 | 122295 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597632 | 122295 | None | 0 | Guinea pig | Functional | pIC50 | = | 8.4 | 8.4 | 1 | 3 | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 2237 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | |||
| 3634 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | |||
| 4887 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | |||
| 4887.0 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | |||
| DB01411 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.4 | 8.4 | -14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.1c01078 | |||
| 44352294 | 163536 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL419796 | 163536 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 44360752 | 119388 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 557 | 13 | 2 | 4 | 8.6 | Cc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL344169 | 119388 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 557 | 13 | 2 | 4 | 8.6 | Cc1ccc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/j.bmc.2010.06.047 | |||
| 10436360 | 15315 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 510 | 9 | 1 | 7 | 5.2 | CN(C)CCOc1c(-c2ccc(OCc3ccc4ccccc4n3)cc2)oc2c(C(=O)O)cccc2c1=O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213781 | 15315 | None | 0 | Human | Functional | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 510 | 9 | 1 | 7 | 5.2 | CN(C)CCOc1c(-c2ccc(OCc3ccc4ccccc4n3)cc2)oc2c(C(=O)O)cccc2c1=O | 10.1016/j.bmc.2010.06.047 | |||
| 57109 | 83516 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm960088k | |||
| CHEMBL22016 | 83516 | None | 25 | Human | Functional | pIC50 | = | 5.4 | 5.4 | 1 | 2 | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm960088k | |||
| 10598159 | 114502 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL33329 | 114502 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 10836133 | 13721 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1cccc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11950 | 13721 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1cccc(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| 44360808 | 32652 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 545 | 13 | 3 | 5 | 6.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc(C(=O)O)cn2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL141300 | 32652 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 545 | 13 | 3 | 5 | 6.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc(C(=O)O)cn2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 10053523 | 15325 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 559 | 8 | 1 | 6 | 6.8 | CCCOc1c(-c2cccc(OCc3ccc4ccccc4n3)c2)oc2c(C(=O)O)cc(Br)cc2c1=O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213920 | 15325 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 559 | 8 | 1 | 6 | 6.8 | CCCOc1c(-c2cccc(OCc3ccc4ccccc4n3)c2)oc2c(C(=O)O)cc(Br)cc2c1=O | 10.1016/j.bmc.2010.06.047 | |||
| 44352142 | 18860 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL128151 | 18860 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 118716777 | 115092 | None | 2 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 3 | 2 | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342956 | 115092 | None | 2 | Human | Functional | pIC50 | = | 7.4 | 7.4 | 3 | 2 | ChEMBL | 546 | 14 | 3 | 6 | 5.2 | O=C(O)CCCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 3381 | 589 | None | 19 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -17 | 3 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | |||
| 5311015 | 589 | None | 19 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -17 | 3 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | |||
| CHEMBL285954 | 589 | None | 19 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -17 | 3 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1021/ml500298y | |||
| 10600630 | 12616 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 475 | 8 | 2 | 7 | 5.1 | O=C(/C=C/c1cccc(/C=C/c2ccc3ccccc3n2)c1)c1cc(OCc2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11870 | 12616 | None | 0 | Human | Functional | pIC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 475 | 8 | 2 | 7 | 5.1 | O=C(/C=C/c1cccc(/C=C/c2ccc3ccccc3n2)c1)c1cc(OCc2nn[nH]n2)ccc1O | 10.1016/j.bmc.2010.06.047 | |||
| 10836131 | 11272 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11791 | 11272 | None | 0 | Human | Functional | pIC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 122183686 | 122254 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -3 | 2 | ChEMBL | 555 | 15 | 2 | 5 | 7.0 | COc1ccccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597529 | 122254 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -3 | 2 | ChEMBL | 555 | 15 | 2 | 5 | 7.0 | COc1ccccc1CCCCOc1ccc(/C=C/c2cccc3c(CCCC(=O)O)c(C)n(CC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 118716772 | 115084 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | |||
| CHEMBL3342948 | 115084 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | |||
| 59599552 | 148391 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | -12 | 2 | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3936830 | 148391 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | -12 | 2 | ChEMBL | 437 | 7 | 2 | 8 | 4.2 | CC(=O)c1ccc(OCc2cccc(Oc3ccc(-c4nn[nH]n4)cn3)c2)c(Cl)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 59599616 | 146352 | None | 1 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)nc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3920609 | 146352 | None | 1 | Human | Functional | pIC50 | = | 6.3 | 6.3 | 1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2ccc(Oc3cccc(-c4nn[nH]n4)c3)nc2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 118729615 | 117985 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | -6 | 2 | ChEMBL | 542 | 15 | 2 | 7 | 6.0 | O=C(O)CCCOc1nc2cccc(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)c2nc1C(=O)O | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3403189 | 117985 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | -6 | 2 | ChEMBL | 542 | 15 | 2 | 7 | 6.0 | O=C(O)CCCOc1nc2cccc(/C=C/c3ccc(OCCCCOc4ccccc4)cc3)c2nc1C(=O)O | 10.1016/j.bmc.2015.03.011 | |||
| 49863923 | 15385 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 626 | 8 | 2 | 6 | 7.1 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(/C=C/c3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214532 | 15385 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 626 | 8 | 2 | 6 | 7.1 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](CO)c2cc(/C=C/c3ccc4ccc(C)cc4n3)ccc2OC1(C)C | 10.1016/j.bmc.2010.06.047 | |||
| 122183757 | 122285 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 10 | 2 | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597622 | 122285 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 10 | 2 | ChEMBL | 571 | 12 | 2 | 4 | 7.2 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 127043618 | 140612 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 2570 | 2 | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1cccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3810210 | 140612 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | 2570 | 2 | ChEMBL | 523 | 7 | 3 | 4 | 6.9 | COc1cccc2c(/C=C/C(=O)Nc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)c(C(=O)O)[nH]c12 | 10.1021/acsmedchemlett.5b00482 | |||
| 10649109 | 119515 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL34507 | 119515 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 11387037 | 115099 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| CHEMBL3342963 | 115099 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 1 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1C[C@H](C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/ml500298y | |||
| 168280068 | 191298 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -5 | 2 | ChEMBL | 293 | 6 | 0 | 3 | 4.6 | CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL5189181 | 191298 | None | 0 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -5 | 2 | ChEMBL | 293 | 6 | 0 | 3 | 4.6 | CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| 136127005 | 15370 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 438 | 7 | 3 | 7 | 3.9 | O=C(/C=C/c1ccc(OCc2nc3ccccc3[nH]2)cc1)c1cc(-c2nnn[nH]2)ccc1O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1214415 | 15370 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 438 | 7 | 3 | 7 | 3.9 | O=C(/C=C/c1ccc(OCc2nc3ccccc3[nH]2)cc1)c1cc(-c2nnn[nH]2)ccc1O | 10.1016/j.bmc.2010.06.047 | |||
| 11796528 | 114217 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL33294 | 114217 | None | 0 | Human | Functional | pIC50 | = | 6.3 | 6.3 | - | 1 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 90871050 | 115083 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 85 | 2 | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1cccc2c1OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | |||
| CHEMBL3342947 | 115083 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | 85 | 2 | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1cccc2c1OC(C(=O)O)CN2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | |||
| 49863641 | 15317 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 358 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc2c(=O)cc(-c3ccc(Oc4ccccc4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213844 | 15317 | None | 0 | Human | Functional | pIC50 | = | 4.3 | 4.3 | - | 1 | ChEMBL | 358 | 4 | 1 | 4 | 5.0 | O=C(O)c1cccc2c(=O)cc(-c3ccc(Oc4ccccc4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 122183761 | 122290 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -1 | 2 | ChEMBL | 613 | 15 | 2 | 4 | 8.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597627 | 122290 | None | 0 | Human | Functional | pIC50 | = | 7.3 | 7.3 | -1 | 2 | ChEMBL | 613 | 15 | 2 | 4 | 8.4 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CCCC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 127043237 | 140507 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 870 | 2 | ChEMBL | 495 | 7 | 3 | 3 | 6.8 | O=C(CCc1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3808985 | 140507 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 870 | 2 | ChEMBL | 495 | 7 | 3 | 3 | 6.8 | O=C(CCc1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 11249398 | 117848 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 519 | 14 | 2 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(OCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3401686 | 117848 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -1 | 2 | ChEMBL | 519 | 14 | 2 | 6 | 5.2 | O=C(O)CCCN1CC(C(=O)O)Oc2c(OCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 46830962 | 122297 | None | 24 | Guinea pig | Functional | pIC50 | = | 8.2 | 8.2 | -3 | 3 | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597634 | 122297 | None | 24 | Guinea pig | Functional | pIC50 | = | 8.2 | 8.2 | -3 | 3 | ChEMBL | 601 | 14 | 2 | 4 | 7.6 | Cc1c(F)cccc1CCCCOc1ccc(C#Cc2ccc(F)c3c(CCCC(=O)O)c(C)n(CCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 10647443 | 13132 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 455 | 6 | 2 | 4 | 6.4 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL11905 | 13132 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 455 | 6 | 2 | 4 | 6.4 | O=C(O)c1cc(Cl)cc(C(=O)/C=C/c2cccc(/C=C/c3ccc4ccccc4n3)c2)c1O | 10.1016/j.bmc.2010.06.047 | |||
| 10717271 | 98651 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL276879 | 98651 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 425 | 7 | 2 | 5 | 5.1 | O=C(O)c1ccc(O)c(C(=O)/C=C/c2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1016/j.bmc.2010.06.047 | |||
| 59599577 | 144973 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3909995 | 144973 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 1 | 2 | ChEMBL | 445 | 9 | 2 | 8 | 4.5 | CCCc1c(OCc2cccc(Oc3cc(-c4nn[nH]n4)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 10532372 | 15326 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 658 | 8 | 1 | 7 | 8.2 | O=C(O)c1cc(Br)cc2c(=O)c(OCc3ccc4ccccc4n3)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213921 | 15326 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 658 | 8 | 1 | 7 | 8.2 | O=C(O)c1cc(Br)cc2c(=O)c(OCc3ccc4ccccc4n3)c(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 122183759 | 122288 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 3 | 2 | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597625 | 122288 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 3 | 2 | ChEMBL | 585 | 13 | 2 | 4 | 7.6 | Cc1c(Cl)cccc1CCCCOc1ccc(C#Cc2cccc3c(CC(=O)O)c(C)n(CCCCC(=O)O)c23)cc1 | 10.1021/acs.jmedchem.5b00741 | |||
| 127043252 | 140478 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 576 | 7 | 2 | 4 | 8.3 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3808623 | 140478 | None | 0 | Human | Functional | pIC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 576 | 7 | 2 | 4 | 8.3 | O=C(/C=C/c1c(C(=O)O)[nH]c2cc(Cl)cc(Cl)c12)OCc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 127043053 | 140615 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 537 | 2 | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cccc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3810290 | 140615 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | 537 | 2 | ChEMBL | 527 | 6 | 3 | 3 | 7.5 | O=C(/C=C/c1c(C(=O)O)[nH]c2cccc(Cl)c12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 44352148 | 18818 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL127842 | 18818 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 44352326 | 20855 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL131025 | 20855 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 46830963 | 122295 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3597632 | 122295 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 3 | ChEMBL | 641 | 14 | 2 | 4 | 7.7 | Cc1c(CCCC(=O)O)c2c(F)ccc(C#Cc3ccc(OCCCCc4c(F)cc(F)c(F)c4F)cc3)c2n1CCCC(=O)O | 10.1021/acs.jmedchem.5b00741 | |||
| 127043244 | 140522 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 5888 | 2 | ChEMBL | 511 | 6 | 3 | 3 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(F)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3809189 | 140522 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 5888 | 2 | ChEMBL | 511 | 6 | 3 | 3 | 7.0 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccc(F)cc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 23124680 | 117849 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -12 | 2 | ChEMBL | 515 | 13 | 2 | 5 | 5.8 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3401687 | 117849 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -12 | 2 | ChEMBL | 515 | 13 | 2 | 5 | 5.8 | O=C(O)CCCN1CC(C(=O)O)Oc2c(/C=C/c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 23124664 | 117853 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -12 | 2 | ChEMBL | 671 | 15 | 3 | 8 | 5.3 | O=C(O)CCCN1CC(C(=O)NS(=O)(=O)c2ccccc2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3401691 | 117853 | None | 0 | Human | Functional | pIC50 | = | 7.2 | 7.2 | -12 | 2 | ChEMBL | 671 | 15 | 3 | 8 | 5.3 | O=C(O)CCCN1CC(C(=O)NS(=O)(=O)c2ccccc2)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 59599576 | 142626 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 5 | 2 | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2cccc(Oc3cc(C(=O)O)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| CHEMBL3890848 | 142626 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | 5 | 2 | ChEMBL | 421 | 9 | 2 | 6 | 5.0 | CCCc1c(OCc2cccc(Oc3cc(C(=O)O)ccn3)c2)ccc(C(C)=O)c1O | 10.1016/j.bmcl.2016.11.049 | |||
| 118729613 | 117980 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -1 | 2 | ChEMBL | 518 | 13 | 3 | 6 | 4.8 | O=C(O)CCCN1CC(CO)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3403184 | 117980 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | -1 | 2 | ChEMBL | 518 | 13 | 3 | 6 | 4.8 | O=C(O)CCCN1CC(CO)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 44352103 | 116754 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL337195 | 116754 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1016/j.bmc.2010.06.047 | |||
| 11191817 | 115091 | None | 2 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL3342955 | 115091 | None | 2 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -3 | 2 | ChEMBL | 532 | 13 | 3 | 6 | 4.9 | O=C(O)CCCN1CC(C(=O)O)Oc2c(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1021/acs.jmedchem.5b00741 | |||
| 49863579 | 15311 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL1213720 | 15311 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 517 | 5 | 2 | 6 | 5.8 | O=C(O)c1cc(Br)cc2c(=O)c(O)c(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 23124707 | 117850 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -5 | 2 | ChEMBL | 517 | 14 | 2 | 5 | 5.4 | O=C(O)CCCN1CC(C(=O)O)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| CHEMBL3401688 | 117850 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | -5 | 2 | ChEMBL | 517 | 14 | 2 | 5 | 5.4 | O=C(O)CCCN1CC(C(=O)O)Oc2c(CCc3ccc(OCCCCc4ccccc4)cc3)cccc21 | 10.1016/j.bmc.2015.03.011 | |||
| 118716773 | 115085 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)NCC(C(=O)O)O2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | |||
| CHEMBL3342949 | 115085 | None | 0 | Human | Functional | pIC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 446 | 9 | 3 | 5 | 4.6 | O=C(Nc1ccc2c(c1)NCC(C(=O)O)O2)c1ccc(OCCCCc2ccccc2)cc1 | 10.1021/ml500298y | |||
| 44352397 | 21203 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL131287 | 21203 | None | 0 | Human | Functional | pIC50 | = | 7.1 | 7.1 | - | 1 | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1016/j.bmc.2010.06.047 | |||
| 127043050 | 140526 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 6456 | 2 | ChEMBL | 493 | 6 | 3 | 3 | 6.9 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| CHEMBL3809230 | 140526 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | 6456 | 2 | ChEMBL | 493 | 6 | 3 | 3 | 6.9 | O=C(/C=C/c1c(C(=O)O)[nH]c2ccccc12)Nc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/acsmedchemlett.5b00482 | |||
| 44352186 | 22073 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL132167 | 22073 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1016/j.bmc.2010.06.047 | |||
| 44352154 | 165121 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| CHEMBL422609 | 165121 | None | 0 | Human | Functional | pIC50 | = | 8.0 | 8.0 | - | 1 | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1016/j.bmc.2010.06.047 | |||
| 10472005 | 16836 | None | 0 | Guinea pig | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 333 | 5 | 0 | 4 | 4.3 | COC(=O)COc1cccc(/C=C/c2ccc3cc(C)ccc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL124741 | 16836 | None | 0 | Guinea pig | Functional | pIC50 | = | 6.0 | 6.0 | - | 1 | ChEMBL | 333 | 5 | 0 | 4 | 4.3 | COC(=O)COc1cccc(/C=C/c2ccc3cc(C)ccc3n2)c1 | 10.1021/jm00099a011 | |||
| 168288290 | 191463 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -95 | 2 | ChEMBL | 307 | 6 | 0 | 3 | 5.0 | CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| CHEMBL5192002 | 191463 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -95 | 2 | ChEMBL | 307 | 6 | 0 | 3 | 5.0 | CCC(C)Oc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/acs.jmedchem.1c01078 | |||
| 54677430 | 115082 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -1 | 2 | ChEMBL | 510 | 8 | 2 | 7 | 5.1 | CCN(CC)C(=O)/C=C(\C)c1ccc2oc(C(=O)c3ccc(C#N)cc3)c(NC(=O)/C(C#N)=C(/C)O)c2c1 | 10.1021/ml500298y | |||
| CHEMBL3342946 | 115082 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -1 | 2 | ChEMBL | 510 | 8 | 2 | 7 | 5.1 | CCN(CC)C(=O)/C=C(\C)c1ccc2oc(C(=O)c3ccc(C#N)cc3)c(NC(=O)/C(C#N)=C(/C)O)c2c1 | 10.1021/ml500298y | |||
| 14626814 | 184445 | None | 0 | Human | Functional | pKd | = | 10.1 | 10.1 | - | 0 | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL48435 | 184445 | None | 0 | Human | Functional | pKd | = | 10.1 | 10.1 | - | 0 | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 145979664 | 166691 | None | 0 | Human | Functional | pKd | = | 10 | 10.0 | - | 0 | ChEMBL | 595 | 8 | 2 | 7 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL4280282 | 166691 | None | 0 | Human | Functional | pKd | = | 10 | 10.0 | - | 0 | ChEMBL | 595 | 8 | 2 | 7 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 22848867 | 14766 | None | 0 | Guinea pig | Functional | pKd | = | 9.4 | 9.4 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206453 | 14766 | None | 0 | Guinea pig | Functional | pKd | = | 9.4 | 9.4 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL275357 | 14766 | None | 0 | Guinea pig | Functional | pKd | = | 9.4 | 9.4 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 14626863 | 168014 | None | 1 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 0 | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL431348 | 168014 | None | 1 | Human | Functional | pKd | = | 9.1 | 9.1 | - | 0 | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 22848869 | 14605 | None | 0 | Guinea pig | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204695 | 14605 | None | 0 | Guinea pig | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15306 | 14605 | None | 0 | Guinea pig | Functional | pKd | = | 9.1 | 9.1 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 145987347 | 167253 | None | 0 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 0 | ChEMBL | 608 | 8 | 3 | 6 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL4290919 | 167253 | None | 0 | Human | Functional | pKd | = | 8.9 | 8.9 | - | 0 | ChEMBL | 608 | 8 | 3 | 6 | 6.0 | COc1cc(C(=O)NS(=O)(=O)c2cccc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 10346 | 2559 | None | 36 | Guinea pig | Functional | pKd | = | 8.8 | 8.8 | 3 | 2 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Functional | pKd | = | 8.8 | 8.8 | 3 | 2 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Functional | pKd | = | 8.8 | 8.8 | 3 | 2 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| 22848881 | 14771 | None | 0 | Guinea pig | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206471 | 14771 | None | 0 | Guinea pig | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL277533 | 14771 | None | 0 | Guinea pig | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44269759 | 44189 | None | 0 | Guinea pig | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15161 | 44189 | None | 0 | Guinea pig | Functional | pKd | = | 8.8 | 8.8 | - | 1 | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 145981186 | 166619 | None | 1 | Human | Functional | pKd | = | 8.7 | 8.7 | - | 0 | ChEMBL | 574 | 8 | 3 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL4279086 | 166619 | None | 1 | Human | Functional | pKd | = | 8.7 | 8.7 | - | 0 | ChEMBL | 574 | 8 | 3 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 19794942 | 100433 | None | 0 | Guinea pig | Functional | pKd | = | 7 | 7.0 | - | 0 | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL289880 | 100433 | None | 0 | Guinea pig | Functional | pKd | = | 7 | 7.0 | - | 0 | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 145987301 | 167183 | None | 0 | Human | Functional | pKd | = | 7.9 | 7.9 | - | 0 | ChEMBL | 592 | 8 | 3 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2cccc(F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL4289768 | 167183 | None | 0 | Human | Functional | pKd | = | 7.9 | 7.9 | - | 0 | ChEMBL | 592 | 8 | 3 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2cccc(F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 145992748 | 167122 | None | 0 | Human | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 588 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL4288574 | 167122 | None | 0 | Human | Functional | pKd | = | 7.6 | 7.6 | - | 0 | ChEMBL | 588 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 19794942 | 100433 | None | 0 | Guinea pig | Functional | pKd | = | 8.4 | 8.4 | - | 0 | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL289880 | 100433 | None | 0 | Guinea pig | Functional | pKd | = | 8.4 | 8.4 | - | 0 | ChEMBL | 520 | 16 | 2 | 5 | 6.7 | O=C(O)CCC(/C=C/Cc1ccc(OCCCCOc2ccccc2)cc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 145994218 | 167422 | None | 0 | Human | Functional | pKd | = | 8.3 | 8.3 | - | 0 | ChEMBL | 642 | 8 | 3 | 6 | 6.4 | COc1cc(C(=O)NS(=O)(=O)c2cccc(C(F)(F)F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL4294239 | 167422 | None | 0 | Human | Functional | pKd | = | 8.3 | 8.3 | - | 0 | ChEMBL | 642 | 8 | 3 | 6 | 6.4 | COc1cc(C(=O)NS(=O)(=O)c2cccc(C(F)(F)F)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 22848883 | 14765 | None | 0 | Guinea pig | Functional | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206448 | 14765 | None | 0 | Guinea pig | Functional | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL274913 | 14765 | None | 0 | Guinea pig | Functional | pKd | = | 8.3 | 8.3 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 105007 | 97153 | None | 25 | Guinea pig | Functional | pKd | = | 7.3 | 7.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | |||
| CHEMBL267475 | 97153 | None | 25 | Guinea pig | Functional | pKd | = | 7.3 | 7.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | |||
| CHEMBL267976 | 97153 | None | 25 | Guinea pig | Functional | pKd | = | 7.3 | 7.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00388a028 | |||
| 145992231 | 166999 | None | 0 | Human | Functional | pKd | = | 8.2 | 8.2 | - | 0 | ChEMBL | 642 | 8 | 3 | 6 | 6.7 | COc1cc(C(=O)NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| CHEMBL4286347 | 166999 | None | 0 | Human | Functional | pKd | = | 8.2 | 8.2 | - | 0 | ChEMBL | 642 | 8 | 3 | 6 | 6.7 | COc1cc(C(=O)NS(=O)(=O)c2cc(Cl)cc(Cl)c2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCCC3)cc12 | 10.1021/acs.jmedchem.8b00458 | |||
| 9829784 | 101928 | None | 11 | Guinea pig | Functional | pKi | = | 9.2 | 9.2 | - | 0 | ChEMBL | 582 | 7 | 2 | 7 | 5.9 | C[C@H]1Oc2ccc(OCc3nc4cc(F)ccc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL300701 | 101928 | None | 11 | Guinea pig | Functional | pKi | = | 9.2 | 9.2 | - | 0 | ChEMBL | 582 | 7 | 2 | 7 | 5.9 | C[C@H]1Oc2ccc(OCc3nc4cc(F)ccc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | |||
| 2237 | 3162 | None | 53 | Guinea pig | Functional | pKi | = | 9.1 | 9.1 | 14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | |||
| 3634 | 3162 | None | 53 | Guinea pig | Functional | pKi | = | 9.1 | 9.1 | 14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | |||
| 4887 | 3162 | None | 53 | Guinea pig | Functional | pKi | = | 9.1 | 9.1 | 14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | |||
| 4887.0 | 3162 | None | 53 | Guinea pig | Functional | pKi | = | 9.1 | 9.1 | 14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL21333 | 3162 | None | 53 | Guinea pig | Functional | pKi | = | 9.1 | 9.1 | 14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | |||
| DB01411 | 3162 | None | 53 | Guinea pig | Functional | pKi | = | 9.1 | 9.1 | 14 | 10 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(98)00654-4 | |||
| 9956127 | 169484 | None | 13 | Guinea pig | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL442150 | 169484 | None | 13 | Guinea pig | Functional | pKi | = | 7.9 | 7.9 | - | 0 | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/s0960-894x(98)00654-4 | |||
| 2855 | 4132 | None | 63 | Guinea pig | Functional | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | |||
| 3322 | 4132 | None | 63 | Guinea pig | Functional | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | |||
| 5717 | 4132 | None | 63 | Guinea pig | Functional | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Functional | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Functional | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Functional | pKi | = | 8.7 | 8.7 | -1 | 12 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00654-4 | |||
| 9874234 | 114121 | None | 0 | Guinea pig | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 644 | 8 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL332680 | 114121 | None | 0 | Guinea pig | Functional | pKi | = | 8.7 | 8.7 | - | 0 | ChEMBL | 644 | 8 | 2 | 8 | 6.5 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3nc4cc(F)c(F)cc4s3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | |||
| 9830780 | 13336 | None | 6 | Guinea pig | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 636 | 8 | 2 | 7 | 6.8 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL119214 | 13336 | None | 6 | Guinea pig | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 636 | 8 | 2 | 7 | 6.8 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | |||
| 44345841 | 14531 | None | 0 | Guinea pig | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 648 | 7 | 2 | 7 | 7.1 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cc(NS(=O)(=O)C(F)(F)F)ccc1Cl | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL120200 | 14531 | None | 0 | Guinea pig | Functional | pKi | = | 8.4 | 8.4 | - | 0 | ChEMBL | 648 | 7 | 2 | 7 | 7.1 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cc(NS(=O)(=O)C(F)(F)F)ccc1Cl | 10.1016/s0960-894x(98)00654-4 | |||
| 44346037 | 113477 | None | 0 | Guinea pig | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 632 | 7 | 2 | 6 | 7.4 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(/C=C/c3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL331884 | 113477 | None | 0 | Guinea pig | Functional | pKi | = | 8.3 | 8.3 | - | 0 | ChEMBL | 632 | 7 | 2 | 6 | 7.4 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@H]1[C@@H](O)c2cc(/C=C/c3ccc4ccc(Cl)cc4n3)ccc2OC1(C)C | 10.1016/s0960-894x(98)00654-4 | |||
| 44345821 | 113412 | None | 0 | Guinea pig | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 614 | 7 | 2 | 7 | 6.5 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | |||
| CHEMBL331747 | 113412 | None | 0 | Guinea pig | Functional | pKi | = | 8.2 | 8.2 | - | 0 | ChEMBL | 614 | 7 | 2 | 7 | 6.5 | CC1(C)Oc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@H](O)[C@@H]1Cc1cccc(NS(=O)(=O)C(F)(F)F)c1 | 10.1016/s0960-894x(98)00654-4 | |||
| 53394034 | 588 | None | 21 | Human | Functional | pA2 | = | 6.4 | 6.4 | -21 | 2 | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | |||
| 6196 | 588 | None | 21 | Human | Functional | pA2 | = | 6.4 | 6.4 | -21 | 2 | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | |||
| CHEMBL3342945 | 588 | None | 21 | Human | Functional | pA2 | = | 6.4 | 6.4 | -21 | 2 | Guide to Pharmacology | 589 | 16 | 3 | 6 | 6.0 | OC(=O)C1CCCC(C1)NC(=O)c1cc(ccc1OCCCc1ccc(cc1)OCCCCOc1ccccc1)C(=O)O | 21753081 | |||
| 10002 | 3865 | None | 0 | Human | Functional | pA2 | = | 8.7 | 8.7 | - | 1 | Guide to Pharmacology | 568 | 8 | 3 | 6 | 5.5 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)Nc1ccccc1)C)C(=O)NS(=O)(=O)c1ccccc1 | 29878767 | |||
| 134611898 | 3865 | None | 0 | Human | Functional | pA2 | = | 8.7 | 8.7 | - | 1 | Guide to Pharmacology | 568 | 8 | 3 | 6 | 5.5 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)Nc1ccccc1)C)C(=O)NS(=O)(=O)c1ccccc1 | 29878767 | |||
| 6194 | 2834 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -61 | 2 | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | |||
| 73755185 | 2834 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -61 | 2 | Guide to Pharmacology | 639 | 26 | 7 | 8 | 3.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)NC | 21078884 | |||
| 3352 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | |||
| 5280879 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | |||
| 5863 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | |||
| CHEMBL509456 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.4 | 6.4 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 21078884 | |||
| 3352 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | |||
| 5280879 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | |||
| 5863 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | |||
| CHEMBL509456 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | |||
| 3352 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | |||
| 3352 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | |||
| 3352 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | |||
| 5280879 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | |||
| 5280879 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | |||
| 5280879 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | |||
| 5863 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | |||
| 5863 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | |||
| 5863 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | |||
| CHEMBL509456 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10462554 | |||
| CHEMBL509456 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10913337 | |||
| CHEMBL509456 | 2371 | None | 24 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 11093801 | |||
| 3354 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | |||
| 3354 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | |||
| 3354 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | |||
| 5280493 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | |||
| 5280493 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | |||
| 5280493 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | |||
| CHEMBL451509 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | |||
| CHEMBL451509 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | |||
| CHEMBL451509 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | |||
| DB08855 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10462554 | |||
| DB08855 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10913337 | |||
| DB08855 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 11093801 | |||
| 3354 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | |||
| 5280493 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | |||
| CHEMBL451509 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | |||
| DB08855 | 2369 | None | 23 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10913337 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 11093801 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 17558309 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 21753081 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 10581 | 983 | None | 0 | Human | Functional | pIC50 | < | 9 | 9.0 | 1819 | 2 | Guide to Pharmacology | 587 | 17 | 2 | 7 | 5.4 | O=C(CN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCc1ccccc1)C(=O)O)CCCC(=O)O | 31811124 | |||
| 145996520 | 983 | None | 0 | Human | Functional | pIC50 | < | 9 | 9.0 | 1819 | 2 | Guide to Pharmacology | 587 | 17 | 2 | 7 | 5.4 | O=C(CN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCc1ccccc1)C(=O)O)CCCC(=O)O | 31811124 | |||
| 2237 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8 | 8.0 | -14 | 10 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| 3634 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8 | 8.0 | -14 | 10 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| 4887 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8 | 8.0 | -14 | 10 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| 4887.0 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8 | 8.0 | -14 | 10 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8 | 8.0 | -14 | 10 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| DB01411 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8 | 8.0 | -14 | 10 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| 10582 | 991 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -194 | 2 | Guide to Pharmacology | 573 | 17 | 2 | 6 | 6.2 | OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O | 31811124 | |||
| 145996521 | 991 | None | 0 | Human | Functional | pIC50 | = | 6.9 | 6.9 | -194 | 2 | Guide to Pharmacology | 573 | 17 | 2 | 6 | 6.2 | OC(=O)CCCCN1CC(Oc2c1cccc2CC(=O)c1ccc(cc1)OCCCCCCc1ccccc1)C(=O)O | 31811124 | |||
| 2237 | 3162 | None | 53 | Human | Functional | pIC50 | = | 10 | 10.0 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| 3634 | 3162 | None | 53 | Human | Functional | pIC50 | = | 10 | 10.0 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| 4887 | 3162 | None | 53 | Human | Functional | pIC50 | = | 10 | 10.0 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| 4887.0 | 3162 | None | 53 | Human | Functional | pIC50 | = | 10 | 10.0 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Functional | pIC50 | = | 10 | 10.0 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| DB01411 | 3162 | None | 53 | Human | Functional | pIC50 | = | 10 | 10.0 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| 3381 | 589 | None | 19 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -17 | 3 | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | |||
| 5311015 | 589 | None | 19 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -17 | 3 | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | |||
| CHEMBL285954 | 589 | None | 19 | Human | Functional | pIC50 | = | 5.3 | 5.3 | -17 | 3 | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 20423349 | |||
| 3381 | 589 | None | 19 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -17 | 3 | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | |||
| 5311015 | 589 | None | 19 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -17 | 3 | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | |||
| CHEMBL285954 | 589 | None | 19 | Human | Functional | pIC50 | = | 6.4 | 6.4 | -17 | 3 | Guide to Pharmacology | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 11093801 | |||
| 3354 | 2369 | None | 23 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | |||
| 5280493 | 2369 | None | 23 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | |||
| CHEMBL451509 | 2369 | None | 23 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | |||
| DB08855 | 2369 | None | 23 | Human | Functional | pIC50 | = | 6.5 | 6.5 | -74 | 4 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 10391245 | |||
| 3352 | 2371 | None | 24 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | |||
| 5280879 | 2371 | None | 24 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | |||
| 5863 | 2371 | None | 24 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | |||
| CHEMBL509456 | 2371 | None | 24 | Human | Functional | pIC50 | = | 6.8 | 6.8 | -575 | 4 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 10391245 | |||
| 3334 | 3147 | None | 8 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 48 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | |||
| 60842 | 3147 | None | 8 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 48 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | |||
| CHEMBL22776 | 3147 | None | 8 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 48 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | |||
| 2855 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | |||
| 3322 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | |||
| 5717 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | |||
| 5717.0 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | |||
| DB00549 | 4132 | None | 63 | Human | Functional | pIC50 | = | 7.7 | 7.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 20423349 | |||
| 3353 | 2370 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | |||
| 3412 | 2370 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | |||
| 6435286 | 2370 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -4 | 4 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10462554 | |||
| 2237 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | |||
| 2237 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| 3634 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | |||
| 3634 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| 4887 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | |||
| 4887 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| 4887.0 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | |||
| 4887.0 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| DB01411 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10391245 | |||
| DB01411 | 3162 | None | 53 | Human | Functional | pIC50 | = | 8.3 | 8.3 | -14 | 10 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10462554 | |||
| 3334 | 3147 | None | 8 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 48 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | |||
| 60842 | 3147 | None | 8 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 48 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | |||
| CHEMBL22776 | 3147 | None | 8 | Human | Functional | pIC50 | = | 8.3 | 8.3 | 48 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10462554 | |||
| 1836 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| 3340 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| 5281040 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| 5281040.0 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| DB00471 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.6 | 8.6 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| 2855 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| 3322 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| 5717 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| 5717.0 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| DB00549 | 4132 | None | 63 | Human | Functional | pIC50 | = | 9.6 | 9.6 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| 1836 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | |||
| 1836 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| 3340 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | |||
| 3340 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| 5281040 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | |||
| 5281040 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| 5281040.0 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | |||
| 5281040.0 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| DB00471 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10391245 | |||
| DB00471 | 2592 | None | 44 | Human | Functional | pIC50 | = | 8.5 | 8.5 | -10 | 20 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10462554 | |||
| 2855 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | |||
| 2855 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| 3322 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | |||
| 3322 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| 5717 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | |||
| 5717 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| 5717.0 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | |||
| 5717.0 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| DB00549 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10391245 | |||
| DB00549 | 4132 | None | 63 | Human | Functional | pIC50 | = | 8.7 | 8.7 | 1 | 12 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10462554 | |||
| 6193 | 3984 | None | 31 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | |||
| 6509849 | 3984 | None | 31 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | |||
| CHEMBL280481 | 3984 | None | 31 | Human | Functional | pIC50 | = | 8.1 | 8.1 | -1 | 2 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | |||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 2237 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 10.4 | 10.4 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| 3634 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 10.4 | 10.4 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| 4887 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 10.4 | 10.4 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| 4887.0 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 10.4 | 10.4 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL21333 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 10.4 | 10.4 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| DB01411 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 10.4 | 10.4 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| 15236851 | 112862 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL330649 | 112862 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 0 | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(95)00023-M | |||
| 22848867 | 14766 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206453 | 14766 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL275357 | 14766 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.7 | 9.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 9829145 | 119391 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL344180 | 119391 | None | 0 | Human | Binding | pIC50 | = | 9.6 | 9.6 | - | 0 | ChEMBL | 555 | 12 | 2 | 4 | 8.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| 44329532 | 210101 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL95234 | 210101 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | |||
| 10099896 | 210872 | None | 11 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 587 | 12 | 2 | 4 | 9.2 | CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL99775 | 210872 | None | 11 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 587 | 12 | 2 | 4 | 9.2 | CC(C)(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | |||
| 10074173 | 16614 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 486 | 11 | 2 | 5 | 5.9 | NC(=O)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL124095 | 16614 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 486 | 11 | 2 | 5 | 5.9 | NC(=O)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| 22848867 | 14766 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206453 | 14766 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL275357 | 14766 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 15859376 | 210404 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL96986 | 210404 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| 44269827 | 14601 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204691 | 14601 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL14819 | 14601 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 558 | 12 | 2 | 6 | 7.1 | O=C(O)CCSC(CCc1ccccc1-c1nc[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44320022 | 106050 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccc(CC[C@@H](SCC2(CC(=O)O)CC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)cc1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL313187 | 106050 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccc(CC[C@@H](SCC2(CC(=O)O)CC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)cc1 | 10.1016/0960-894X(95)00448-3 | |||
| 15872197 | 207771 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 632 | 8 | 2 | 8 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL79366 | 207771 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 632 | 8 | 2 | 8 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 44213972 | 207839 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 694 | 9 | 2 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL79952 | 207839 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 694 | 9 | 2 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(C)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 44461050 | 208255 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 674 | 8 | 2 | 9 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL83166 | 208255 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 674 | 8 | 2 | 9 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N2CCOCC2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 44269877 | 14967 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1208514 | 14967 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15232 | 14967 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 601 | 13 | 1 | 8 | 7.2 | CCC(CSC(CCc1ccccc1-c1nnnn1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44269762 | 14604 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204694 | 14604 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15292 | 14604 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44269966 | 14607 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204697 | 14607 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15370 | 14607 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44360858 | 119362 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 583 | 12 | 2 | 4 | 8.7 | CC1(C)CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL343934 | 119362 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 583 | 12 | 2 | 4 | 8.7 | CC1(C)CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | |||
| 22849291 | 108396 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL319802 | 108396 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 573 | 12 | 2 | 4 | 8.8 | CC(CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/0960-894X(95)00023-M | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00023-M | |||
| 22849284 | 210511 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | CC(S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(C)C(=O)O | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL97576 | 210511 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | CC(S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(C)C(=O)O | 10.1016/0960-894X(95)00023-M | |||
| 15291446 | 35203 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL143515 | 35203 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 541 | 12 | 2 | 4 | 7.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| 44269964 | 14777 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206505 | 14777 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL280310 | 14777 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 590 | 14 | 2 | 5 | 7.7 | CCNC(=O)c1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44360585 | 119156 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL342705 | 119156 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 569 | 12 | 2 | 4 | 8.6 | CC1CCCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | |||
| 44319718 | 106053 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2cccc(C3(O)CCC3)c2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL313195 | 106053 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2cccc(C3(O)CCC3)c2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 44270016 | 14603 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204693 | 14603 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15120 | 14603 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 562 | 13 | 2 | 5 | 7.1 | CCC(CSC(CCc1ccccc1C(N)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44269966 | 14607 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204697 | 14607 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15370 | 14607 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 550 | 12 | 1 | 6 | 7.5 | CC(CSC(CCc1ccccc1[N+](=O)[O-])c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44461124 | 104603 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 660 | 10 | 2 | 8 | 6.5 | CCN(CC)C(=O)n1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL310446 | 104603 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 660 | 10 | 2 | 8 | 6.5 | CCN(CC)C(=O)n1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1016/s0960-894x(98)00442-9 | |||
| 44213973 | 105471 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 604 | 8 | 3 | 8 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(N)=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL311868 | 105471 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 604 | 8 | 3 | 8 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(N)=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 10439506 | 207781 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 675 | 11 | 3 | 9 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCN(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL79479 | 207781 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 675 | 11 | 3 | 9 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCN(C)C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 10372711 | 207819 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 722 | 12 | 3 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCCc2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL79741 | 207819 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 722 | 12 | 3 | 8 | 7.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)NCCCc2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 1836 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | |||
| 3340 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | |||
| 5281040 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | |||
| 5281040.0 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | |||
| CHEMBL787 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | |||
| DB00471 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.3 | 9.3 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm960088k | |||
| 1836 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | |||
| 3340 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | |||
| 5281040 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | |||
| 5281040.0 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL787 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | |||
| DB00471 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/0960-894X(95)00023-M | |||
| 1836 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | |||
| 3340 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | |||
| 5281040 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | |||
| 5281040.0 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | |||
| CHEMBL787 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | |||
| DB00471 | 2592 | None | 44 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b00472 | |||
| 44288760 | 162273 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL416251 | 162273 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44269410 | 14596 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1204685 | 14596 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL14268 | 14596 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 525 | 13 | 2 | 4 | 8.3 | CC(CC[C@H](SCCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 9829365 | 14602 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204692 | 14602 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15035 | 14602 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 19767826 | 14774 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206492 | 14774 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL279630 | 14774 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44270023 | 44000 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 576 | 12 | 1 | 5 | 7.3 | CC(CSC(CCc1ccccc1C(=O)N(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15132 | 44000 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 576 | 12 | 1 | 5 | 7.3 | CC(CSC(CCc1ccccc1C(=O)N(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 9809348 | 208798 | None | 1 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL87337 | 208798 | None | 1 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 625 | 12 | 2 | 5 | 9.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| 44360674 | 118635 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL341603 | 118635 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 569 | 12 | 2 | 4 | 8.3 | CC1(C)Cc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc2C1 | 10.1016/s0960-894x(98)00051-1 | |||
| 44269954 | 14764 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206442 | 14764 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL274049 | 14764 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 22849285 | 210130 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 573 | 12 | 2 | 4 | 8.9 | CCC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL95362 | 210130 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 573 | 12 | 2 | 4 | 8.9 | CCC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| 15859377 | 210119 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL95317 | 210119 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | C[C@H](CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| 44288760 | 162273 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL416251 | 162273 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 561 | 13 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44269347 | 14599 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1204689 | 14599 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL14451 | 14599 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 44269378 | 14761 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1206432 | 14761 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL273343 | 14761 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 44209267 | 14773 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206480 | 14773 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL278411 | 14773 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 602 | 12 | 1 | 5 | 8.0 | O=C(O)CCSC(CCc1ccccc1C(=O)N1CCCCC1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44270043 | 14606 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204696 | 14606 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15344 | 14606 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44269762 | 14604 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204694 | 14604 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15292 | 14604 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 570 | 12 | 2 | 6 | 6.0 | NS(=O)(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44269954 | 14764 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206442 | 14764 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL274049 | 14764 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 584 | 13 | 2 | 6 | 6.7 | CS(=O)(=O)Nc1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 19767826 | 14774 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206492 | 14774 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL279630 | 14774 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 604 | 14 | 2 | 5 | 8.8 | CCOC(=O)Nc1ccccc1CCC(SCC(CC)C(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44360643 | 30896 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL139757 | 30896 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 559 | 12 | 2 | 5 | 7.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CSC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| 44319717 | 161956 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccc(C3(O)CCC3)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL414885 | 161956 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccc(C3(O)CCC3)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 9985552 | 107276 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 573 | 11 | 2 | 4 | 8.9 | CC(C)(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL316688 | 107276 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 573 | 11 | 2 | 4 | 8.9 | CC(C)(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| 5280878 | 100327 | None | 24 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | |||
| CHEMBL288943 | 100327 | None | 24 | Human | Binding | pIC50 | = | 9.2 | 9.2 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | |||
| 44288372 | 100193 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL287722 | 100193 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| 44319715 | 208600 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 597 | 12 | 2 | 5 | 8.9 | O=C(O)CC1(CS[C@H](CCc2ccccc2CO)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL86063 | 208600 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 597 | 12 | 2 | 5 | 8.9 | O=C(O)CC1(CS[C@H](CCc2ccccc2CO)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 15290709 | 106628 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(F)c(F)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL314237 | 106628 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(F)c(F)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| 10346 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| 1836 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.1 | 9.1 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | |||
| 3340 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.1 | 9.1 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | |||
| 5281040 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.1 | 9.1 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | |||
| 5281040.0 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.1 | 9.1 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.1 | 9.1 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | |||
| DB00471 | 2592 | None | 44 | Human | Binding | pIC50 | = | 9.1 | 9.1 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1016/s0960-894x(98)00051-1 | |||
| 10076489 | 210696 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | CC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL98676 | 210696 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 559 | 11 | 2 | 4 | 8.6 | CC(CC(=O)O)S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00023-M | |||
| 10346 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00099a011 | |||
| 44288159 | 163814 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)c(F)cc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL42051 | 163814 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 593 | 12 | 2 | 5 | 8.6 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)c(F)cc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44288695 | 168711 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL43602 | 168711 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44269325 | 14767 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1206456 | 14767 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL275823 | 14767 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 44269924 | 14772 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206475 | 14772 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL278210 | 14772 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 587 | 13 | 2 | 7 | 7.2 | CCC(CSC(CCc1ccccc1-c1nn[nH]n1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 9829365 | 14602 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204692 | 14602 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15035 | 14602 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | CC(CSC(CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44269329 | 14872 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1207565 | 14872 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL415981 | 14872 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 44269759 | 44189 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15161 | 44189 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 587 | 13 | 2 | 4 | 9.2 | CCC[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 45268321 | 198027 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 615 | 9 | 1 | 5 | 7.8 | O=C(O)c1ccccc1OCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL555048 | 198027 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 615 | 9 | 1 | 5 | 7.8 | O=C(O)c1ccccc1OCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 19767793 | 99019 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15513 | 99019 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL279773 | 99019 | None | 0 | Guinea pig | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)c1ccccc1CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44461163 | 4957 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 561 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL1048 | 4957 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 561 | 8 | 3 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 44460797 | 207613 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 611 | 9 | 2 | 7 | 6.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(F)F)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL78140 | 207613 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 611 | 9 | 2 | 7 | 6.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(F)F)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 15872199 | 207614 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 589 | 9 | 2 | 8 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL78141 | 207614 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 589 | 9 | 2 | 8 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C=O)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 2237 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | |||
| 3634 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | |||
| 4887 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | |||
| 4887.0 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | |||
| CHEMBL21333 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | |||
| DB01411 | 3162 | None | 53 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/jm970180w | |||
| 44250106 | 197629 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 523 | 7 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL550456 | 197629 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 523 | 7 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288372 | 100193 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL287722 | 100193 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 617 | 14 | 2 | 5 | 9.3 | CC(CC(F)(F)F)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| 44269376 | 14600 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1204690 | 14600 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL14569 | 14600 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 587 | 12 | 2 | 4 | 9.5 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 44361757 | 34421 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 573 | 12 | 2 | 4 | 8.5 | C[C@H](CS[C@@H](CCc1ccccc1CC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL142803 | 34421 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 573 | 12 | 2 | 4 | 8.5 | C[C@H](CS[C@@H](CCc1ccccc1CC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| 19767776 | 14873 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1207567 | 14873 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL416161 | 14873 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 542 | 12 | 1 | 4 | 8.1 | CCC(CSC(CCc1ccccc1C#N)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44270043 | 14606 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204696 | 14606 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15344 | 14606 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 597 | 13 | 1 | 6 | 7.4 | CCC(CSC(CCc1ccccc1S(C)(=O)=O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44269865 | 14775 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206502 | 14775 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL280260 | 14775 | None | 0 | Guinea pig | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44320021 | 107157 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccccc2C2(O)CCC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL315973 | 107157 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 637 | 12 | 2 | 5 | 9.8 | O=C(O)CC1(CS[C@H](CCc2ccccc2C2(O)CCC2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 44319783 | 107199 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 627 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL316170 | 107199 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 627 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| 44360625 | 33047 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL141640 | 33047 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCCCC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| 15290705 | 106736 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL314340 | 106736 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sc(Cl)cc3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| 45271665 | 197769 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3c(F)cccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL551520 | 197769 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3c(F)cccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 45268226 | 198522 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 545 | 7 | 1 | 6 | 6.2 | Clc1ccc2ccc(/C=C/c3cccc(Cn4c5c(c6ccccc64)CCN(CCc4nnn[nH]4)C5)c3)nc2c1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL560522 | 198522 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 545 | 7 | 1 | 6 | 6.2 | Clc1ccc2ccc(/C=C/c3cccc(Cn4c5c(c6ccccc64)CCN(CCc4nnn[nH]4)C5)c3)nc2c1 | 10.1016/j.bmcl.2009.05.094 | |||
| 45269111 | 198790 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 519 | 5 | 1 | 4 | 6.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(C#Cc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL562383 | 198790 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 519 | 5 | 1 | 4 | 6.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(C#Cc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44269323 | 14595 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1204684 | 14595 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL14180 | 14595 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 539 | 13 | 2 | 4 | 8.7 | CC(C)(O)CCCSC(CCC(C)(C)CC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | |||
| 44269939 | 47999 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | CC(CCC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15500 | 47999 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | CC(CCC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| 44288695 | 168711 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL43602 | 168711 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 575 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44269368 | 14597 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1204687 | 14597 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL14408 | 14597 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 587 | 13 | 2 | 4 | 8.9 | CC(C)(O)c1ccccc1CS[C@@H](CCC1(CC(=O)O)CC1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80300-5 | |||
| 44269880 | 14883 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1207684 | 14883 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL429975 | 14883 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 10346 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| 44288569 | 100263 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 561 | 12 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCCC3)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL288369 | 100263 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 561 | 12 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCCC3)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44269383 | 14763 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1206441 | 14763 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL274038 | 14763 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 532 | 12 | 1 | 4 | 8.3 | CC(C)(CC[C@H](SCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 44319992 | 208628 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 567 | 11 | 1 | 4 | 9.4 | O=C(O)CC1(CS[C@H](CCc2ccccc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL86302 | 208628 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 567 | 11 | 1 | 4 | 9.4 | O=C(O)CC1(CS[C@H](CCc2ccccc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 44250107 | 198313 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 539 | 7 | 1 | 4 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL558638 | 198313 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 539 | 7 | 1 | 4 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44360675 | 32784 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 555 | 12 | 2 | 4 | 8.2 | CC1CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL141405 | 32784 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 555 | 12 | 2 | 4 | 8.2 | CC1CCc2ccc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)nc21 | 10.1016/s0960-894x(98)00051-1 | |||
| 44288430 | 101190 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL295281 | 101190 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 2855 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| 3322 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| 5717 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| 5717.0 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| CHEMBL603 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| DB00549 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.8 | 8.8 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| 2855 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| 3322 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| 5717 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| 5717.0 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| DB00549 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| 2855 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
| 3322 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
| 5717 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
| 5717.0 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
| DB00549 | 4132 | None | 63 | Human | Binding | pIC50 | = | 8.7 | 8.7 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.5b00741 | |||
| 44288716 | 162250 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 549 | 13 | 2 | 5 | 8.3 | CC(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL41620 | 162250 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 549 | 13 | 2 | 5 | 8.3 | CC(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| 44269345 | 14598 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1204688 | 14598 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL14450 | 14598 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 589 | 13 | 2 | 4 | 9.2 | CC(C)(CC[C@@H](SCc1ccccc1C(C)(C)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 19767879 | 167727 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)CCSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL430147 | 167727 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 562 | 12 | 1 | 5 | 7.1 | CN(C)C(=O)CCSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 9829999 | 208439 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3scc(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL84707 | 208439 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3scc(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| 44274381 | 80048 | None | 0 | Guinea pig | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 540 | 17 | 3 | 6 | 6.8 | CCCCC/C=C/C/C=C\C=C\C=C\[C@@H](Sc1ccc2c(=O)cc(C(=O)O)oc2c1)[C@H](O)CCCC(=O)O | 10.1021/jm00108a001 | |||
| CHEMBL21286 | 80048 | None | 0 | Guinea pig | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 540 | 17 | 3 | 6 | 6.8 | CCCCC/C=C/C/C=C\C=C\C=C\[C@@H](Sc1ccc2c(=O)cc(C(=O)O)oc2c1)[C@H](O)CCCC(=O)O | 10.1021/jm00108a001 | |||
| 6518171 | 168399 | None | 38 | Human | Binding | pIC50 | = | 5.0 | 5.0 | -4 | 8 | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | |||
| CHEMBL434063 | 168399 | None | 38 | Human | Binding | pIC50 | = | 5.0 | 5.0 | -4 | 8 | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | |||
| 44288480 | 166060 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL42520 | 166060 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44288324 | 161856 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL41395 | 161856 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 45270816 | 199210 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 527 | 7 | 1 | 5 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3nc4cc(Cl)ccc4s3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL565228 | 199210 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 527 | 7 | 1 | 5 | 7.0 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3nc4cc(Cl)ccc4s3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 45270799 | 197286 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2C(C1)c1ccccc1N2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL549431 | 197286 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2C(C1)c1ccccc1N2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288249 | 159354 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL40992 | 159354 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | |||
| 10051321 | 16912 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 491 | 12 | 2 | 6 | 5.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL125135 | 16912 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 491 | 12 | 2 | 6 | 5.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| 44288613 | 157929 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL40836 | 157929 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | |||
| 45268266 | 198452 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 535 | 6 | 1 | 5 | 7.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2ccc3oc(-c4ccc5ccc(Cl)cc5n4)cc3c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL559928 | 198452 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 535 | 6 | 1 | 5 | 7.1 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2ccc3oc(-c4ccc5ccc(Cl)cc5n4)cc3c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 15289799 | 98712 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 518 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL277332 | 98712 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 518 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 45273388 | 198177 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 537 | 8 | 1 | 4 | 7.1 | O=C(O)CCCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL557105 | 198177 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 537 | 8 | 1 | 4 | 7.1 | O=C(O)CCCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288614 | 96531 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL262391 | 96531 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44319586 | 208263 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 639 | 12 | 2 | 5 | 9.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(C2CC2c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL83233 | 208263 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 639 | 12 | 2 | 5 | 9.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(C2CC2c2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| 45273411 | 195751 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 565 | 9 | 1 | 5 | 7.3 | CCOc1cccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c12)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL541010 | 195751 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 565 | 9 | 1 | 5 | 7.3 | CCOc1cccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c12)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | |||
| 10744393 | 71488 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 514 | 8 | 2 | 5 | 4.7 | O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1 | 10.1021/jm058225d | |||
| CHEMBL196220 | 71488 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 514 | 8 | 2 | 5 | 4.7 | O=C(N[C@H](CN1CCC(OC2c3ccccc3CCc3ccccc32)CC1)C(=O)O)OCc1ccccc1 | 10.1021/jm058225d | |||
| 45268250 | 198780 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c2c1)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL562324 | 198780 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c3c(n(Cc4cccc(/C=C/c5ccc6ccc(Cl)cc6n5)c4)c2c1)CCN(CCC(=O)O)C3 | 10.1016/j.bmcl.2009.05.094 | |||
| 45270063 | 198878 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 549 | 9 | 1 | 4 | 7.7 | O=C(O)CCCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL562906 | 198878 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 549 | 9 | 1 | 4 | 7.7 | O=C(O)CCCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 45269186 | 199175 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 521 | 7 | 1 | 4 | 6.9 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL564954 | 199175 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 521 | 7 | 1 | 4 | 6.9 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 9829198 | 161400 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3ccccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL41230 | 161400 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3ccccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 10526098 | 99753 | None | 1 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | |||
| CHEMBL284624 | 99753 | None | 1 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | |||
| 10574284 | 117037 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | |||
| CHEMBL33871 | 117037 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970180w | |||
| 45270876 | 197630 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 507 | 6 | 1 | 4 | 6.5 | O=C(O)CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL550458 | 197630 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 507 | 6 | 1 | 4 | 6.5 | O=C(O)CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 22848883 | 14765 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206448 | 14765 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL274913 | 14765 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44288589 | 101474 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL297396 | 101474 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | |||
| 448537 | 160344 | None | 54 | Human | Binding | pIC50 | = | 4.8 | 4.8 | -41 | 25 | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | |||
| CHEMBL411 | 160344 | None | 54 | Human | Binding | pIC50 | = | 4.8 | 4.8 | -41 | 25 | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | |||
| 44288589 | 101474 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL297396 | 101474 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 583 | 13 | 2 | 5 | 9.0 | CC(C)c1nc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)sc1Cl | 10.1016/0960-894X(95)00265-U | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00442-9 | |||
| 9853580 | 106204 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 756 | 10 | 2 | 8 | 9.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| CHEMBL313567 | 106204 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 756 | 10 | 2 | 8 | 9.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C(=O)N(c2ccccc2)c2ccccc2)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1016/s0960-894x(98)00442-9 | |||
| 44360640 | 31543 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL140381 | 31543 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 569 | 12 | 2 | 4 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| 44288735 | 162271 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL416249 | 162271 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| 44269386 | 14875 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1207573 | 14875 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL416344 | 14875 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 511 | 12 | 2 | 4 | 7.9 | C[C@H](CCC[C@H](SCCC(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 44361753 | 33950 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 529 | 11 | 1 | 4 | 8.0 | C[C@H](CS[C@@H](CCc1ccccc1C=O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL142395 | 33950 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 529 | 11 | 1 | 4 | 8.0 | C[C@H](CS[C@@H](CCc1ccccc1C=O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| 22848869 | 14605 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204695 | 14605 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15306 | 14605 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44269865 | 14775 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206502 | 14775 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL280260 | 14775 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 7.7 | CCC(CSC(CCc1ccccc1C(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44319587 | 208549 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 629 | 13 | 2 | 6 | 9.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(OCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL85633 | 208549 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 629 | 13 | 2 | 6 | 9.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(OCc2ccc3sc(Cl)c(Cl)c3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| 44288714 | 155236 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 589 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL40213 | 155236 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 589 | 13 | 2 | 5 | 9.3 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CCCCC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44361755 | 35425 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1cccc(CO)c1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL143788 | 35425 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1cccc(CO)c1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| 44319872 | 208852 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 585 | 11 | 1 | 4 | 9.6 | O=C(O)CC1(CS[C@H](CCc2ccc(F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL87696 | 208852 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 585 | 11 | 1 | 4 | 9.6 | O=C(O)CC1(CS[C@H](CCc2ccc(F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 9985190 | 158264 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 556 | 11 | 1 | 6 | 6.2 | O=C(O)CCSC(SCCC(=O)N1CCOCC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL408753 | 158264 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 556 | 11 | 1 | 6 | 6.2 | O=C(O)CCSC(SCCC(=O)N1CCOCC1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| 44269370 | 14768 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1206457 | 14768 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL276036 | 14768 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 546 | 13 | 1 | 4 | 8.4 | CC(C)(CC[C@H](SCCc1ccccn1)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 1836 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| 3340 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| 5281040 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| 5281040.0 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| CHEMBL787 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| DB00471 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| 1836 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | |||
| 3340 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | |||
| 5281040 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | |||
| 5281040.0 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | |||
| DB00471 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.5b00741 | |||
| 15859378 | 111599 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL327942 | 111599 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 573 | 11 | 2 | 4 | 8.8 | C[C@H](S[C@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)[C@@H](C)C(=O)O | 10.1016/0960-894X(95)00023-M | |||
| 44269352 | 14776 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL1206504 | 14776 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| CHEMBL280298 | 14776 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 524 | 12 | 1 | 4 | 7.2 | C[C@H](CCC[C@H](SCCC(=O)N(C)C)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80300-5 | |||
| 1836 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | |||
| 3340 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | |||
| 5281040 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | |||
| 5281040.0 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | |||
| DB00471 | 2592 | None | 44 | Human | Binding | pIC50 | = | 8.6 | 8.6 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/acs.jmedchem.6b01287 | |||
| 44319978 | 208539 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccccc2Br)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL85572 | 208539 | None | 0 | Human | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccccc2Br)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 10346 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| 45269140 | 198643 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3cc(F)ccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL561381 | 198643 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3cc(F)ccc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 15859367 | 35520 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 559 | 11 | 2 | 4 | 8.4 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL143874 | 35520 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.6 | 8.6 | - | 0 | ChEMBL | 559 | 11 | 2 | 4 | 8.4 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| 44360644 | 31190 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 559 | 12 | 2 | 5 | 7.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCS3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL140058 | 31190 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 559 | 12 | 2 | 5 | 7.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)CCS3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| 45272522 | 198241 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL557850 | 198241 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 523 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCC2c3ccccc3N(Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 22848883 | 14765 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206448 | 14765 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL274913 | 14765 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 14541296 | 197238 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 540 | 15 | 2 | 7 | 6.3 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(CCC)(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| CHEMBL54744 | 197238 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 540 | 15 | 2 | 7 | 6.3 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(CCC)(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| 45268240 | 198669 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 555 | 7 | 1 | 4 | 7.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(Cl)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL561524 | 198669 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 555 | 7 | 1 | 4 | 7.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4cc(Cl)c(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL4463974 | 216407 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | None | None | None | Cn1nccc1-c1ccc(Sc2ccc(C3(C(N)=O)CCOCC3)cc2)cc1 | 10.1016/j.ejmech.2023.115151 | |||||
| 128355 | 3669 | None | 19 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | |||
| 3329 | 3669 | None | 19 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | |||
| CHEMBL18132 | 3669 | None | 19 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00108a001 | |||
| 128355 | 3669 | None | 19 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | |||
| 3329 | 3669 | None | 19 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | |||
| CHEMBL18132 | 3669 | None | 19 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | 10.1021/jm00166a017 | |||
| 13997664 | 60363 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 405 | 8 | 2 | 4 | 4.9 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL174483 | 60363 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 405 | 8 | 2 | 4 | 4.9 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(C(=O)O)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | |||
| 45270792 | 198827 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 523 | 8 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(CCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL562575 | 198827 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 523 | 8 | 1 | 4 | 6.5 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(CCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 10097610 | 14811 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL1207034 | 14811 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL339713 | 14811 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 503 | 13 | 2 | 5 | 6.5 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| 45273491 | 198251 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 535 | 6 | 1 | 4 | 6.4 | O=C(O)CC(=O)N1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL557924 | 198251 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 535 | 6 | 1 | 4 | 6.4 | O=C(O)CC(=O)N1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 19930521 | 46873 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15405 | 46873 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 5352624 | 67260 | None | 35 | Human | Binding | pIC50 | = | 4.5 | 4.5 | -4 | 5 | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | |||
| CHEMBL18797 | 67260 | None | 35 | Human | Binding | pIC50 | = | 4.5 | 4.5 | -4 | 5 | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | |||
| 45270885 | 198062 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 585 | 7 | 1 | 4 | 7.9 | O=C(O)c1ccc(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5cc(F)c(F)cc5n4)c3)C2)cc1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL555910 | 198062 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 585 | 7 | 1 | 4 | 7.9 | O=C(O)c1ccc(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5cc(F)c(F)cc5n4)c3)C2)cc1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288196 | 169033 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL43874 | 169033 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | |||
| 9829423 | 32559 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL141233 | 32559 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| 10346 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| 6193 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | |||
| 6509849 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | |||
| CHEMBL280481 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm960088k | |||
| 6193 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| 6509849 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| CHEMBL280481 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00023-M | |||
| 6193 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | |||
| 6509849 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | |||
| CHEMBL280481 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/acs.jmedchem.6b00472 | |||
| 10346 | 2559 | None | 36 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| 5281888 | 2559 | None | 36 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| CHEMBL15177 | 2559 | None | 36 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| 44361773 | 33071 | None | 1 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1ccccc1CO)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL141665 | 33071 | None | 1 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 531 | 11 | 2 | 4 | 7.7 | C[C@H](CS[C@@H](CCc1ccccc1CO)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| 6193 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| 6509849 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| CHEMBL280481 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| 45273490 | 197987 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 561 | 8 | 1 | 4 | 7.7 | O=C(O)CC1(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2)CC1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL554154 | 197987 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 561 | 8 | 1 | 4 | 7.7 | O=C(O)CC1(CN2CCc3c(c4ccccc4n3Cc3cccc(/C=C/c4ccc5ccc(Cl)cc5n4)c3)C2)CC1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288430 | 101190 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL295281 | 101190 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 547 | 13 | 2 | 5 | 8.1 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(C3CC3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44288735 | 162271 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL416249 | 162271 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 563 | 12 | 2 | 5 | 8.5 | CC(C)(C)c1csc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)n1 | 10.1016/0960-894X(95)00265-U | |||
| 9959856 | 168564 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 575 | 12 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL43509 | 168564 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 575 | 12 | 2 | 5 | 8.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44319827 | 208831 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL87528 | 208831 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 45272532 | 198296 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 505 | 7 | 1 | 4 | 6.4 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL558443 | 198296 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 505 | 7 | 1 | 4 | 6.4 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 45268232 | 198626 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 494 | 8 | 1 | 3 | 7.8 | Cc1c(CCCC(=O)O)c2ccccc2n1Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL561321 | 198626 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 494 | 8 | 1 | 3 | 7.8 | Cc1c(CCCC(=O)O)c2ccccc2n1Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44269922 | 98610 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 592 | 13 | 2 | 6 | 6.6 | CC(CSC(CCc1ccccc1C(=O)N(C)CO)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL276584 | 98610 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 592 | 13 | 2 | 6 | 6.6 | CC(CSC(CCc1ccccc1C(=O)N(C)CO)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44361485 | 35300 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 557 | 12 | 1 | 4 | 8.8 | CCC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL143639 | 35300 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 557 | 12 | 1 | 4 | 8.8 | CCC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| 44361525 | 119479 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 573 | 12 | 1 | 5 | 8.4 | CCOC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL344756 | 119479 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 573 | 12 | 1 | 5 | 8.4 | CCOC(=O)c1ccccc1CC[C@H](SC[C@@H](C)C(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| 6193 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | |||
| 6509849 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL280481 | 3984 | None | 31 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/0960-894X(95)00265-U | |||
| 10346 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| 137660132 | 159613 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 429 | 8 | 1 | 7 | 4.2 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(-n4cnnn4)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL4102154 | 159613 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 429 | 8 | 1 | 7 | 4.2 | CCCCCc1ccc(/C=C/C(=O)Nc2cccc3c(=O)cc(-n4cnnn4)oc23)cc1 | 10.1021/acs.jmedchem.6b01287 | |||
| 45269187 | 198507 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 535 | 8 | 1 | 4 | 7.3 | O=C(O)CCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL560385 | 198507 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 535 | 8 | 1 | 4 | 7.3 | O=C(O)CCCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 132306 | 75437 | None | 16 | Guinea pig | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 397 | 5 | 0 | 5 | 3.9 | COC1(c2cc(F)cc(OCc3ccc4c(ccc(=O)n4C)c3)c2)CCOCC1 | 10.1016/j.ejmech.2023.115151 | |||
| CHEMBL20403 | 75437 | None | 16 | Guinea pig | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 397 | 5 | 0 | 5 | 3.9 | COC1(c2cc(F)cc(OCc3ccc4c(ccc(=O)n4C)c3)c2)CCOCC1 | 10.1016/j.ejmech.2023.115151 | |||
| 10391331 | 170183 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 501 | 11 | 2 | 5 | 6.6 | O=C(O)CCSC(SCCC(=O)O)c1cccc(C2CC2c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL444331 | 170183 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 501 | 11 | 2 | 5 | 6.6 | O=C(O)CCSC(SCCC(=O)O)c1cccc(C2CC2c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| 10399041 | 117070 | None | 1 | Guinea pig | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1ccncc1 | 10.1021/jm00099a011 | |||
| CHEMBL338876 | 117070 | None | 1 | Guinea pig | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1ccncc1 | 10.1021/jm00099a011 | |||
| 2812 | 4781 | None | 63 | Human | Binding | pIC50 | = | 4.5 | 4.5 | -58 | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
| CHEMBL104 | 4781 | None | 63 | Human | Binding | pIC50 | = | 4.5 | 4.5 | -58 | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
| 19930521 | 46873 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15405 | 46873 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 516 | 12 | 1 | 5 | 6.1 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 45270815 | 197658 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 499 | 7 | 1 | 5 | 6.4 | CC(C)(C)c1csc(/C=C/c2cccc(Cn3c4c(c5ccccc53)CN(CCC(=O)O)CC4)c2)n1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL550654 | 197658 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 499 | 7 | 1 | 5 | 6.4 | CC(C)(C)c1csc(/C=C/c2cccc(Cn3c4c(c5ccccc53)CN(CCC(=O)O)CC4)c2)n1 | 10.1016/j.bmcl.2009.05.094 | |||
| 9871637 | 162066 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 507 | 12 | 2 | 5 | 7.2 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nccs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL415903 | 162066 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 507 | 12 | 2 | 5 | 7.2 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nccs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 22848869 | 14605 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204695 | 14605 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15306 | 14605 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@H](CS[C@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 45268320 | 198820 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 533 | 7 | 1 | 4 | 7.1 | O=C(O)/C=C/CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL562524 | 198820 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 533 | 7 | 1 | 4 | 7.1 | O=C(O)/C=C/CN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 2237 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
| 3634 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
| 4887 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
| 4887.0 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
| DB01411 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.5b00741 | |||
| 44361688 | 14891 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 605 | 12 | 1 | 4 | 9.4 | C[C@H](CS[C@@H](CCc1ccccc1C(=O)c1ccccc1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL120779 | 14891 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 605 | 12 | 1 | 4 | 9.4 | C[C@H](CS[C@@H](CCc1ccccc1C(=O)c1ccccc1)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/0960-894X(94)80017-0 | |||
| 45271634 | 197333 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 480 | 8 | 1 | 3 | 7.5 | O=C(O)CCCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL549700 | 197333 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 480 | 8 | 1 | 3 | 7.5 | O=C(O)CCCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | |||
| 2237 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| 3634 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| 4887 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| 4887.0 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| DB01411 | 3162 | None | 53 | Human | Binding | pIC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1021/acs.jmedchem.6b01287 | |||
| 45272547 | 198102 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3ccc(F)cc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL556420 | 198102 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 541 | 7 | 1 | 4 | 6.7 | O=C(O)CCN1CCc2c(c3ccc(F)cc3n2Cc2cccc(/C=C/c3ccc4cc(F)c(F)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288196 | 169033 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL43874 | 169033 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 547 | 12 | 2 | 5 | 7.7 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3c(s2)CCC3)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44319977 | 208214 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccc(Br)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL82790 | 208214 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 645 | 11 | 1 | 4 | 10.2 | O=C(O)CC1(CS[C@H](CCc2ccc(Br)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 45273394 | 198883 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 516 | 7 | 1 | 3 | 8.2 | O=C(O)CCc1ccc2c(c1)c1ccccc1n2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL562930 | 198883 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 516 | 7 | 1 | 3 | 8.2 | O=C(O)CCc1ccc2c(c1)c1ccccc1n2Cc1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1016/j.bmcl.2009.05.094 | |||
| 45267392 | 199153 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 506 | 6 | 1 | 3 | 7.6 | O=C(O)CC1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL564798 | 199153 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 506 | 6 | 1 | 3 | 7.6 | O=C(O)CC1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 57109 | 83516 | None | 25 | Guinea pig | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| CHEMBL22016 | 83516 | None | 25 | Guinea pig | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| 105007 | 97153 | None | 25 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | |||
| CHEMBL267475 | 97153 | None | 25 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | |||
| CHEMBL267976 | 97153 | None | 25 | Human | Binding | pIC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm960088k | |||
| 57109 | 83516 | None | 25 | Guinea pig | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| CHEMBL22016 | 83516 | None | 25 | Guinea pig | Binding | pIC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| 45271619 | 197829 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 525 | 8 | 1 | 5 | 6.3 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(OCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL551923 | 197829 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 525 | 8 | 1 | 5 | 6.3 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(OCc3ccc4ccc(Cl)cc4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288373 | 156668 | None | 1 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 629 | 15 | 2 | 6 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(CSc3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL40686 | 156668 | None | 1 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 629 | 15 | 2 | 6 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(CSc3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pIC50 | = | 7.4 | 7.4 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(98)00137-1 | |||
| 10073436 | 14589 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL1204572 | 14589 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL338166 | 14589 | None | 0 | Guinea pig | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 470 | 11 | 3 | 6 | 4.9 | O=C(O)CCSC(SCCC(=O)O)c1cccc(NC(=O)c2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | |||
| 44288320 | 165615 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 587 | 13 | 2 | 6 | 8.4 | COc1ccc2nc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)sc2c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL42410 | 165615 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 587 | 13 | 2 | 6 | 8.4 | COc1ccc2nc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)sc2c1 | 10.1016/0960-894X(95)00265-U | |||
| 44360844 | 119859 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 583 | 12 | 2 | 4 | 8.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| CHEMBL348229 | 119859 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 583 | 12 | 2 | 4 | 8.8 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3c(n2)C(C)(C)CCC3)c1 | 10.1016/s0960-894x(98)00051-1 | |||
| 22848881 | 14771 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206471 | 14771 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL277533 | 14771 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44288249 | 159354 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL40992 | 159354 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 563 | 13 | 2 | 5 | 8.6 | Cc1sc(/C=C/c2cccc([C@@H](CCc3ccccc3C(C)(C)O)SCC3(CC(=O)O)CC3)c2)nc1C(C)C | 10.1016/0960-894X(95)00265-U | |||
| 44361742 | 34424 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL142805 | 34424 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 543 | 11 | 1 | 4 | 8.4 | CC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| 45273410 | 199085 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 561 | 7 | 1 | 5 | 7.6 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL564275 | 199085 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 561 | 7 | 1 | 5 | 7.6 | O=C(O)CCN1CCc2c(c3ccccc3n2Cc2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 14329740 | 197309 | None | 2 | Guinea pig | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CC[C@@H](C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| CHEMBL54955 | 197309 | None | 2 | Guinea pig | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 498 | 13 | 2 | 7 | 5.2 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CC[C@@H](C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| 14329749 | 194791 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 512 | 14 | 2 | 7 | 5.5 | CCCc1c(OCCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| CHEMBL53252 | 194791 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 512 | 14 | 2 | 7 | 5.5 | CCCc1c(OCCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| 42611190 | 3156 | None | 14 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -575 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| 5802 | 3156 | None | 14 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -575 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| CHEMBL1800685 | 3156 | None | 14 | Human | Binding | pIC50 | = | 6.3 | 6.3 | -575 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| 10413257 | 16510 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 489 | 12 | 2 | 5 | 6.1 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL123623 | 16510 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 489 | 12 | 2 | 5 | 6.1 | O=C(O)CCSC(SCCC(=O)O)c1cccc(CCc2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| 9888588 | 62546 | None | 4 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 424 | 9 | 2 | 4 | 5.2 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(F)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | |||
| CHEMBL178221 | 62546 | None | 4 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 424 | 9 | 2 | 4 | 5.2 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(F)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | |||
| 44288180 | 144675 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL39077 | 144675 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44269986 | 14608 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204698 | 14608 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15419 | 14608 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 547 | 12 | 1 | 4 | 8.7 | CC(CSC(CCc1ccccc1C(C)C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44319716 | 106048 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 733 | 12 | 2 | 5 | 10.7 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(O)(C(F)(F)F)C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL313177 | 106048 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 733 | 12 | 2 | 5 | 10.7 | O=C(O)CC1(CS[C@H](CCc2ccccc2C(O)(C(F)(F)F)C(F)(F)F)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 44270014 | 14609 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1204699 | 14609 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15481 | 14609 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 491 | 11 | 1 | 4 | 7.3 | O=C(O)CCSC(CCc1ccccc1)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44269880 | 14883 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1207684 | 14883 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL429975 | 14883 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 716 | 15 | 2 | 7 | 8.4 | CCC(CSC(CCc1ccccc1C(=O)NS(=O)(=O)c1ccccc1C)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 44288614 | 96531 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL262391 | 96531 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 601 | 13 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(F)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44288480 | 166060 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL42520 | 166060 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 583 | 13 | 2 | 5 | 8.9 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccccc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44350320 | 16679 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 486 | 11 | 1 | 5 | 6.6 | CN(C)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL124259 | 16679 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 486 | 11 | 1 | 5 | 6.6 | CN(C)CCSC(SCCC(=O)O)c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1 | 10.1021/jm00099a011 | |||
| 5357469 | 18561 | None | 17 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 231 | 2 | 0 | 1 | 4.4 | C(=C/c1ccc2ccccc2n1)\c1ccccc1 | 10.1021/jm00099a011 | |||
| CHEMBL127579 | 18561 | None | 17 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 231 | 2 | 0 | 1 | 4.4 | C(=C/c1ccc2ccccc2n1)\c1ccccc1 | 10.1021/jm00099a011 | |||
| 5376707 | 18808 | None | 12 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1cccnc1 | 10.1021/jm00099a011 | |||
| CHEMBL127816 | 18808 | None | 12 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 232 | 2 | 0 | 2 | 3.8 | C(=C/c1ccc2ccccc2n1)\c1cccnc1 | 10.1021/jm00099a011 | |||
| 14329737 | 198210 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 470 | 11 | 2 | 7 | 4.4 | CCCc1c(OCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| CHEMBL55750 | 198210 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 470 | 11 | 2 | 7 | 4.4 | CCCc1c(OCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)O3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| 45267388 | 198920 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 509 | 9 | 1 | 4 | 7.0 | CN(CCC(=O)O)Cc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL563165 | 198920 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 509 | 9 | 1 | 4 | 7.0 | CN(CCC(=O)O)Cc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | |||
| 22416877 | 60445 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 440 | 9 | 2 | 4 | 5.7 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | |||
| CHEMBL175119 | 60445 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 440 | 9 | 2 | 4 | 5.7 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | |||
| 5280878 | 100327 | None | 24 | Human | Binding | pIC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmc.2010.07.034 | |||
| CHEMBL288943 | 100327 | None | 24 | Human | Binding | pIC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmc.2010.07.034 | |||
| 44361511 | 34219 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 559 | 11 | 1 | 5 | 8.0 | COC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| CHEMBL142627 | 34219 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 559 | 11 | 1 | 5 | 8.0 | COC(=O)c1cccc(CC[C@H](SC[C@@H](C)C(=O)O)c2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c1 | 10.1016/0960-894X(94)80017-0 | |||
| 22848881 | 14771 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL1206471 | 14771 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL277533 | 14771 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 563 | 12 | 2 | 5 | 7.8 | C[C@@H](CS[C@@H](CCc1ccccc1C(C)(C)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)C(=O)O | 10.1016/S0960-894X(00)80635-6 | |||
| 45270818 | 197682 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c(c1)c1c(n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)CCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL550859 | 197682 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 551 | 8 | 1 | 5 | 6.9 | COc1ccc2c(c1)c1c(n2Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)CCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288324 | 161856 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL41395 | 161856 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 625 | 12 | 2 | 5 | 9.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(C(F)(F)F)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 44288180 | 144675 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL39077 | 144675 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 591 | 12 | 2 | 5 | 9.0 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc3cc(Cl)ccc3s2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 14541261 | 190275 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 532 | 11 | 2 | 7 | 5.7 | CCCc1c(OCc2cccc(COc3cc4c(cc3C(C)=O)CCC(C(=O)O)O4)c2)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| CHEMBL51739 | 190275 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 532 | 11 | 2 | 7 | 5.7 | CCCc1c(OCc2cccc(COc3cc4c(cc3C(C)=O)CCC(C(=O)O)O4)c2)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| 14541297 | 194806 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 496 | 13 | 2 | 6 | 5.6 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)C3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| CHEMBL53347 | 194806 | None | 0 | Guinea pig | Binding | pIC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 496 | 13 | 2 | 6 | 5.6 | CCCc1c(OCCCCCOc2cc3c(cc2C(C)=O)CCC(C(=O)O)C3)ccc(C(C)=O)c1O | 10.1021/jm00128a028 | |||
| 10392358 | 47887 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 534 | 12 | 1 | 6 | 6.6 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15491 | 47887 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 534 | 12 | 1 | 6 | 6.6 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccc(Cl)cc3n2)c1 | 10.1016/S0960-894X(00)80635-6 | |||
| 44288319 | 168974 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL43821 | 168974 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 6193 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| 6509849 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| CHEMBL280481 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00172a025 | |||
| 15290701 | 208623 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sccc3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL86264 | 208623 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 557 | 12 | 2 | 5 | 8.4 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2ccc3sccc3n2)c1 | 10.1016/0960-894X(95)00448-3 | |||
| 44269987 | 47820 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 528 | 13 | 1 | 5 | 6.6 | CC(CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| CHEMBL15485 | 47820 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 528 | 13 | 1 | 5 | 6.6 | CC(CCC(SCCC(=O)O)c1cccc(OCc2ccc3ccc(Cl)cc3n2)c1)CC(=O)N(C)C | 10.1016/S0960-894X(00)80635-6 | |||
| 44319774 | 208455 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccc(C(F)(F)F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| CHEMBL84841 | 208455 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 635 | 11 | 1 | 4 | 10.5 | O=C(O)CC1(CS[C@H](CCc2ccc(C(F)(F)F)cc2)c2cccc(/C=C/c3ccc4sc(Cl)c(Cl)c4n3)c2)CC1 | 10.1016/0960-894X(95)00448-3 | |||
| 44350182 | 16592 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 500 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | |||
| CHEMBL123958 | 16592 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 500 | 12 | 1 | 6 | 5.9 | CN(C)C(=O)CCSC(SCCC(=O)O)c1cccc(SCc2ccc3ccccc3n2)c1 | 10.1021/jm00099a011 | |||
| 9822618 | 129802 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 406 | 9 | 2 | 4 | 5.0 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccccc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | |||
| CHEMBL367424 | 129802 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 406 | 9 | 2 | 4 | 5.0 | CCC(CC)(CC(=O)Nc1cccc(OCc2ccc3ccccc3n2)c1)C(=O)O | 10.1016/s0960-894x(98)00137-1 | |||
| 45271629 | 198008 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 523 | 10 | 1 | 4 | 7.0 | CN(CCC(=O)O)CCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | |||
| CHEMBL554691 | 198008 | None | 0 | Guinea pig | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 523 | 10 | 1 | 4 | 7.0 | CN(CCC(=O)O)CCc1cn(Cc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)c2ccccc12 | 10.1016/j.bmcl.2009.05.094 | |||
| 44288613 | 157929 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL40836 | 157929 | None | 0 | Guinea pig | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 613 | 14 | 2 | 6 | 8.9 | COc1ccc(-c2csc(/C=C/c3cccc([C@@H](CCc4ccccc4C(C)(C)O)SCC4(CC(=O)O)CC4)c3)n2)cc1 | 10.1016/0960-894X(95)00265-U | |||
| 44288319 | 168974 | None | 0 | Guinea pig | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| CHEMBL43821 | 168974 | None | 0 | Guinea pig | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 617 | 13 | 2 | 5 | 9.5 | CC(C)(O)c1ccccc1CC[C@@H](SCC1(CC(=O)O)CC1)c1cccc(/C=C/c2nc(-c3ccc(Cl)cc3)cs2)c1 | 10.1016/0960-894X(95)00265-U | |||
| 10346 | 2559 | None | 36 | Guinea pig | Binding | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Binding | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Binding | pKd | = | 9 | 9.0 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00166a017 | |||
| 10839186 | 119771 | None | 0 | Guinea pig | Binding | pKd | = | 7 | 7.0 | - | 1 | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL34740 | 119771 | None | 0 | Guinea pig | Binding | pKd | = | 7 | 7.0 | - | 1 | ChEMBL | 502 | 5 | 1 | 6 | 5.4 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ncc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| 9890153 | 162613 | None | 0 | Guinea pig | Binding | pKd | = | 8.0 | 8.0 | - | 1 | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL416769 | 162613 | None | 0 | Guinea pig | Binding | pKd | = | 8.0 | 8.0 | - | 1 | ChEMBL | 453 | 4 | 1 | 4 | 6.5 | O=C(O)c1cc(Cl)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| 10764782 | 162834 | None | 0 | Guinea pig | Binding | pKd | = | 6.0 | 6.0 | - | 1 | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| CHEMBL417135 | 162834 | None | 0 | Guinea pig | Binding | pKd | = | 6.0 | 6.0 | - | 1 | ChEMBL | 424 | 5 | 1 | 6 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ncc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| 15485487 | 113724 | None | 0 | Guinea pig | Binding | pKd | = | 5.0 | 5.0 | - | 1 | ChEMBL | 477 | 4 | 1 | 6 | 6.0 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2c(-c3nn[nH]n3)cc(Cl)cc12 | 10.1021/jm970179x | |||
| CHEMBL33228 | 113724 | None | 0 | Guinea pig | Binding | pKd | = | 5.0 | 5.0 | - | 1 | ChEMBL | 477 | 4 | 1 | 6 | 6.0 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2c(-c3nn[nH]n3)cc(Cl)cc12 | 10.1021/jm970179x | |||
| 105007 | 97153 | None | 25 | Guinea pig | Binding | pKd | = | 6.0 | 6.0 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | |||
| CHEMBL267475 | 97153 | None | 25 | Guinea pig | Binding | pKd | = | 6.0 | 6.0 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | |||
| CHEMBL267976 | 97153 | None | 25 | Guinea pig | Binding | pKd | = | 6.0 | 6.0 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00013a023 | |||
| 10649085 | 118807 | None | 0 | Guinea pig | Binding | pKd | = | 6.0 | 6.0 | - | 1 | ChEMBL | 500 | 5 | 1 | 4 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5c4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL34177 | 118807 | None | 0 | Guinea pig | Binding | pKd | = | 6.0 | 6.0 | - | 1 | ChEMBL | 500 | 5 | 1 | 4 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5c4)c3)oc12 | 10.1021/jm970179x | |||
| 10792471 | 116771 | None | 0 | Guinea pig | Binding | pKd | = | 7.9 | 7.9 | - | 1 | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL33729 | 116771 | None | 0 | Guinea pig | Binding | pKd | = | 7.9 | 7.9 | - | 1 | ChEMBL | 535 | 5 | 1 | 5 | 6.7 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccc(Cl)cc5n4)c3)oc12 | 10.1021/jm970179x | |||
| 10717827 | 99766 | None | 0 | Guinea pig | Binding | pKd | = | 6.9 | 6.9 | - | 1 | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(O)c1cc(F)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL284730 | 99766 | None | 0 | Guinea pig | Binding | pKd | = | 6.9 | 6.9 | - | 1 | ChEMBL | 437 | 4 | 1 | 4 | 6.0 | O=C(O)c1cc(F)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| 10765224 | 119874 | None | 0 | Guinea pig | Binding | pKd | = | 7.9 | 7.9 | - | 1 | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | |||
| CHEMBL34835 | 119874 | None | 0 | Guinea pig | Binding | pKd | = | 7.9 | 7.9 | - | 1 | ChEMBL | 433 | 4 | 1 | 4 | 6.2 | Cc1cc(C(=O)O)c2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | |||
| 10526098 | 99753 | None | 1 | Guinea pig | Binding | pKd | = | 7.8 | 7.8 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL284624 | 99753 | None | 1 | Guinea pig | Binding | pKd | = | 7.8 | 7.8 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| 10767627 | 109162 | None | 0 | Guinea pig | Binding | pKd | = | 7.8 | 7.8 | - | 1 | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL32136 | 109162 | None | 0 | Guinea pig | Binding | pKd | = | 7.8 | 7.8 | - | 1 | ChEMBL | 497 | 4 | 1 | 4 | 6.6 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| 10574284 | 117037 | None | 0 | Guinea pig | Binding | pKd | = | 7.8 | 7.8 | - | 1 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL33871 | 117037 | None | 0 | Guinea pig | Binding | pKd | = | 7.8 | 7.8 | - | 1 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| 10764530 | 112417 | None | 0 | Guinea pig | Binding | pKd | = | 5.8 | 5.8 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc2c1 | 10.1021/jm970179x | |||
| CHEMBL32944 | 112417 | None | 0 | Guinea pig | Binding | pKd | = | 5.8 | 5.8 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2c(=O)cc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)oc2c1 | 10.1021/jm970179x | |||
| 10787157 | 114172 | None | 0 | Guinea pig | Binding | pKd | = | 5.8 | 5.8 | - | 1 | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | |||
| CHEMBL33276 | 114172 | None | 0 | Guinea pig | Binding | pKd | = | 5.8 | 5.8 | - | 1 | ChEMBL | 400 | 3 | 0 | 4 | 6.1 | N#Cc1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | |||
| 10577476 | 114504 | None | 0 | Guinea pig | Binding | pKd | = | 6.7 | 6.7 | - | 1 | ChEMBL | 504 | 5 | 1 | 6 | 5.4 | Cn1c(COc2cccc(-c3cc(=O)c4cc(Br)cc(C(=O)O)c4o3)c2)nc2ccccc21 | 10.1021/jm970179x | |||
| CHEMBL33331 | 114504 | None | 0 | Guinea pig | Binding | pKd | = | 6.7 | 6.7 | - | 1 | ChEMBL | 504 | 5 | 1 | 6 | 5.4 | Cn1c(COc2cccc(-c3cc(=O)c4cc(Br)cc(C(=O)O)c4o3)c2)nc2ccccc21 | 10.1021/jm970179x | |||
| 44461723 | 208413 | None | 0 | Guinea pig | Binding | pKd | = | 5.6 | 5.6 | -398 | 2 | ChEMBL | 519 | 8 | 0 | 8 | 7.0 | O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12 | 10.1021/jm00013a023 | |||
| CHEMBL84407 | 208413 | None | 0 | Guinea pig | Binding | pKd | = | 5.6 | 5.6 | -398 | 2 | ChEMBL | 519 | 8 | 0 | 8 | 7.0 | O=c1cc(C2N=NN=N2)oc2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc12 | 10.1021/jm00013a023 | |||
| 10502162 | 111534 | None | 0 | Guinea pig | Binding | pKd | = | 6.6 | 6.6 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| CHEMBL32764 | 111534 | None | 0 | Guinea pig | Binding | pKd | = | 6.6 | 6.6 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1cccc2c(=O)cc(-c3ccc(/C=C/c4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| 115219 | 1978 | None | 12 | Guinea pig | Binding | pKd | = | 4.5 | 4.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | |||
| 3358 | 1978 | None | 12 | Guinea pig | Binding | pKd | = | 4.5 | 4.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | |||
| 3414 | 1978 | None | 12 | Guinea pig | Binding | pKd | = | 4.5 | 4.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | |||
| CHEMBL22033 | 1978 | None | 12 | Guinea pig | Binding | pKd | = | 4.5 | 4.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1016/S0960-894X(97)00219-9 | |||
| 15485486 | 116502 | None | 0 | Guinea pig | Binding | pKd | = | 6.5 | 6.5 | - | 1 | ChEMBL | 443 | 4 | 1 | 6 | 5.4 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2ccc(-c3nn[nH]n3)cc12 | 10.1021/jm970179x | |||
| CHEMBL33607 | 116502 | None | 0 | Guinea pig | Binding | pKd | = | 6.5 | 6.5 | - | 1 | ChEMBL | 443 | 4 | 1 | 6 | 5.4 | O=c1cc(-c2cccc(/C=C/c3ccc4ccccc4n3)c2)oc2ccc(-c3nn[nH]n3)cc12 | 10.1021/jm970179x | |||
| 10553494 | 109177 | None | 0 | Guinea pig | Binding | pKd | = | 7.5 | 7.5 | - | 1 | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL32138 | 109177 | None | 0 | Guinea pig | Binding | pKd | = | 7.5 | 7.5 | - | 1 | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4ccc5ccccc5n4)c3)oc12 | 10.1021/jm970179x | |||
| 10651746 | 99945 | None | 0 | Guinea pig | Binding | pKd | = | 6.4 | 6.4 | - | 1 | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| CHEMBL285994 | 99945 | None | 0 | Guinea pig | Binding | pKd | = | 6.4 | 6.4 | - | 1 | ChEMBL | 640 | 7 | 1 | 7 | 6.5 | O=C(NS(=O)(=O)c1ccccc1)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| 10598159 | 114502 | None | 0 | Guinea pig | Binding | pKd | = | 6.4 | 6.4 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | |||
| CHEMBL33329 | 114502 | None | 0 | Guinea pig | Binding | pKd | = | 6.4 | 6.4 | - | 1 | ChEMBL | 419 | 4 | 1 | 4 | 5.9 | O=C(O)c1ccc2oc(-c3cccc(/C=C/c4ccc5ccccc5n4)c3)cc(=O)c2c1 | 10.1021/jm970179x | |||
| 10435880 | 207818 | None | 0 | Guinea pig | Binding | pKd | = | 5.4 | 5.4 | -707 | 2 | ChEMBL | 495 | 8 | 1 | 5 | 5.9 | O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1 | 10.1021/jm00013a023 | |||
| CHEMBL79732 | 207818 | None | 0 | Guinea pig | Binding | pKd | = | 5.4 | 5.4 | -707 | 2 | ChEMBL | 495 | 8 | 1 | 5 | 5.9 | O=C(O)c1cc(=O)c2cc(OCCCN3CCC(=C(c4ccccc4)c4ccccc4)CC3)ccc2o1 | 10.1021/jm00013a023 | |||
| 10649109 | 119515 | None | 0 | Guinea pig | Binding | pKd | = | 6.3 | 6.3 | - | 1 | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| CHEMBL34507 | 119515 | None | 0 | Guinea pig | Binding | pKd | = | 6.3 | 6.3 | - | 1 | ChEMBL | 501 | 5 | 1 | 5 | 6.0 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| 11796528 | 114217 | None | 0 | Guinea pig | Binding | pKd | = | 6.3 | 6.3 | - | 1 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| CHEMBL33294 | 114217 | None | 0 | Guinea pig | Binding | pKd | = | 6.3 | 6.3 | - | 1 | ChEMBL | 423 | 5 | 1 | 5 | 5.3 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccc5ccccc5n4)cc3)oc12 | 10.1021/jm970179x | |||
| 10619270 | 100066 | None | 0 | Guinea pig | Binding | pKd | = | 4.3 | 4.3 | - | 1 | ChEMBL | 372 | 5 | 1 | 4 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccccc4)cc3)oc12 | 10.1021/jm970179x | |||
| CHEMBL286797 | 100066 | None | 0 | Guinea pig | Binding | pKd | = | 4.3 | 4.3 | - | 1 | ChEMBL | 372 | 5 | 1 | 4 | 4.7 | O=C(O)c1cccc2c(=O)cc(-c3ccc(OCc4ccccc4)cc3)oc12 | 10.1021/jm970179x | |||
| 10553667 | 100169 | None | 0 | Guinea pig | Binding | pKd | = | 7.1 | 7.1 | - | 1 | ChEMBL | 507 | 5 | 1 | 6 | 6.1 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4nc5ccccc5s4)c3)oc12 | 10.1021/jm970179x | |||
| CHEMBL287559 | 100169 | None | 0 | Guinea pig | Binding | pKd | = | 7.1 | 7.1 | - | 1 | ChEMBL | 507 | 5 | 1 | 6 | 6.1 | O=C(O)c1cc(Br)cc2c(=O)cc(-c3cccc(OCc4nc5ccccc5s4)c3)oc12 | 10.1021/jm970179x | |||
| 15675874 | 179748 | None | 0 | Guinea pig | Binding | pKi | = | 10 | 10.0 | - | 1 | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| CHEMBL47430 | 179748 | None | 0 | Guinea pig | Binding | pKi | = | 10 | 10.0 | - | 1 | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| 15675885 | 178606 | None | 0 | Guinea pig | Binding | pKi | = | 9.9 | 9.9 | - | 1 | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(COc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| CHEMBL46663 | 178606 | None | 0 | Guinea pig | Binding | pKi | = | 9.9 | 9.9 | - | 1 | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2cc(COc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| 10346 | 2559 | None | 36 | Guinea pig | Binding | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | |||
| 5281888 | 2559 | None | 36 | Guinea pig | Binding | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | |||
| CHEMBL15177 | 2559 | None | 36 | Guinea pig | Binding | pKi | = | 9.7 | 9.7 | - | 1 | ChEMBL | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10.1021/jm00108a001 | |||
| 5280878 | 100327 | None | 24 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | |||
| CHEMBL288943 | 100327 | None | 24 | Human | Binding | pKi | = | 9.5 | 9.5 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/j.bmcl.2013.01.025 | |||
| 115219 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | |||
| 3358 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | |||
| 3414 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | |||
| CHEMBL22033 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00109a025 | |||
| 15675873 | 172268 | None | 0 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 477 | 7 | 1 | 7 | 4.8 | O=C1CC(c2nnn[nH]2)Oc2cc(CCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| CHEMBL44734 | 172268 | None | 0 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 477 | 7 | 1 | 7 | 4.8 | O=C1CC(c2nnn[nH]2)Oc2cc(CCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm970180w | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00108a001 | |||
| 115219 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | |||
| 3358 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | |||
| 3414 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | |||
| CHEMBL22033 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -489 | 3 | ChEMBL | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 10.1021/jm00108a001 | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/acs.jmedchem.6b01287 | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00168a037 | |||
| 14626819 | 188773 | None | 0 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 559 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL50370 | 188773 | None | 0 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 559 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 10461224 | 117155 | None | 0 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 601 | 11 | 2 | 6 | 6.0 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | |||
| CHEMBL339277 | 117155 | None | 0 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 601 | 11 | 2 | 6 | 6.0 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 9.5 | 9.5 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1021/jm00035a008 | |||
| 10349048 | 97000 | None | 0 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | |||
| CHEMBL26617 | 97000 | None | 0 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | |||
| 10077296 | 20168 | None | 0 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 599 | 11 | 2 | 6 | 5.8 | C=CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | |||
| CHEMBL130463 | 20168 | None | 0 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 599 | 11 | 2 | 6 | 5.8 | C=CCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC3CCCC3)ccc21 | 10.1021/jm00055a011 | |||
| 9895247 | 210266 | None | 2 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 616 | 8 | 2 | 8 | 5.7 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | |||
| CHEMBL96224 | 210266 | None | 2 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 616 | 8 | 2 | 8 | 5.7 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3nc4cc(F)c(F)cc4s3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | |||
| 204056 | 169502 | None | 25 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL442263 | 169502 | None | 25 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 10054552 | 93495 | None | 0 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | |||
| CHEMBL24596 | 93495 | None | 0 | Guinea pig | Binding | pKi | = | 9.4 | 9.4 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | |||
| 1836 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | |||
| 3340 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | |||
| 5281040 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | |||
| 5281040.0 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | |||
| CHEMBL787 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | |||
| DB00471 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm970180w | |||
| 14626858 | 191293 | None | 0 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL51891 | 191293 | None | 0 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 14626821 | 193466 | None | 0 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 588 | 10 | 3 | 6 | 5.8 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(NC(=O)NC3CCCC3)ccc21 | 10.1021/jm00168a037 | |||
| CHEMBL52492 | 193466 | None | 0 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 588 | 10 | 3 | 6 | 5.8 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(NC(=O)NC3CCCC3)ccc21 | 10.1021/jm00168a037 | |||
| 10371436 | 117143 | None | 0 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 603 | 12 | 2 | 6 | 6.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C(C)C | 10.1021/jm00055a011 | |||
| CHEMBL339242 | 117143 | None | 0 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 603 | 12 | 2 | 6 | 6.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C(C)C | 10.1021/jm00055a011 | |||
| 14626858 | 191293 | None | 0 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00055a011 | |||
| CHEMBL51891 | 191293 | None | 0 | Guinea pig | Binding | pKi | = | 9.3 | 9.3 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00055a011 | |||
| 9986282 | 93634 | None | 10 | Guinea pig | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL24652 | 93634 | None | 10 | Guinea pig | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 10258533 | 95875 | None | 0 | Guinea pig | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 635 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL25885 | 95875 | None | 0 | Guinea pig | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 635 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 5280878 | 100327 | None | 24 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/np50094a001 | |||
| CHEMBL288943 | 100327 | None | 24 | Human | Binding | pKi | = | 9.2 | 9.2 | 2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1021/np50094a001 | |||
| 9830317 | 210262 | None | 10 | Guinea pig | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 608 | 8 | 2 | 7 | 6.0 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | |||
| CHEMBL96206 | 210262 | None | 10 | Guinea pig | Binding | pKi | = | 9.2 | 9.2 | - | 1 | ChEMBL | 608 | 8 | 2 | 7 | 6.0 | COc1ccc(NS(=O)(=O)C(F)(F)F)cc1C[C@@H]1COc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2[C@@H]1O | 10.1016/s0960-894x(99)00461-8 | |||
| 10483776 | 114883 | None | 0 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc21 | 10.1021/jm00055a011 | |||
| CHEMBL334122 | 114883 | None | 0 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc21 | 10.1021/jm00055a011 | |||
| 14626814 | 184445 | None | 0 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | -10 | 2 | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL48435 | 184445 | None | 0 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | -10 | 2 | ChEMBL | 561 | 8 | 2 | 7 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | |||
| 14626820 | 102038 | None | 0 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 560 | 8 | 3 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL301498 | 102038 | None | 0 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | - | 1 | ChEMBL | 560 | 8 | 3 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 2237 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | |||
| 3634 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | |||
| 4887 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | |||
| 4887.0 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | |||
| CHEMBL21333 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | |||
| DB01411 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 9.1 | 9.1 | 4 | 3 | ChEMBL | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 10.1016/s0960-894x(99)00461-8 | |||
| 2855 | 4132 | None | 63 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| 3322 | 4132 | None | 63 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| 5717 | 4132 | None | 63 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| 5717.0 | 4132 | None | 63 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| CHEMBL603 | 4132 | None | 63 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| DB00549 | 4132 | None | 63 | Human | Binding | pKi | = | 9.1 | 9.1 | 1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | nan | |||
| 10394412 | 24015 | None | 0 | Guinea pig | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 643 | 13 | 2 | 6 | 7.0 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL133790 | 24015 | None | 0 | Guinea pig | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 643 | 13 | 2 | 6 | 7.0 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 10326077 | 21143 | None | 0 | Guinea pig | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC | 10.1021/jm00055a011 | |||
| CHEMBL131247 | 21143 | None | 0 | Guinea pig | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC | 10.1021/jm00055a011 | |||
| 5280878 | 100327 | None | 24 | Guinea pig | Binding | pKi | = | 9 | 9.0 | -2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL288943 | 100327 | None | 24 | Guinea pig | Binding | pKi | = | 9 | 9.0 | -2 | 2 | ChEMBL | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SC[C@H](N)C(=O)NCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| 14626857 | 101953 | None | 0 | Guinea pig | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 559 | 9 | 3 | 5 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL300846 | 101953 | None | 0 | Guinea pig | Binding | pKi | = | 9 | 9.0 | - | 1 | ChEMBL | 559 | 9 | 3 | 5 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1c[nH]c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 9891157 | 22066 | None | 0 | Guinea pig | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 476 | 8 | 2 | 4 | 5.6 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL132162 | 22066 | None | 0 | Guinea pig | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 476 | 8 | 2 | 4 | 5.6 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 15675887 | 181659 | None | 0 | Guinea pig | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 492 | 6 | 2 | 8 | 4.3 | O=C(Nc1cccc2c1OC(c1nnn[nH]1)CC2=O)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00109a025 | |||
| CHEMBL47662 | 181659 | None | 0 | Guinea pig | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 492 | 6 | 2 | 8 | 4.3 | O=C(Nc1cccc2c1OC(c1nnn[nH]1)CC2=O)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00109a025 | |||
| 14842376 | 99815 | None | 0 | Guinea pig | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 490 | 6 | 2 | 8 | 4.4 | O=C(Nc1cccc2c(=O)cc(-c3nn[nH]n3)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm970180w | |||
| CHEMBL285070 | 99815 | None | 0 | Guinea pig | Binding | pKi | = | 9.0 | 9.0 | - | 1 | ChEMBL | 490 | 6 | 2 | 8 | 4.4 | O=C(Nc1cccc2c(=O)cc(-c3nn[nH]n3)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm970180w | |||
| 1836 | 2592 | None | 44 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| 3340 | 2592 | None | 44 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| 5281040 | 2592 | None | 44 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| 5281040.0 | 2592 | None | 44 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| CHEMBL787 | 2592 | None | 44 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| DB00471 | 2592 | None | 44 | Human | Binding | pKi | = | 8.9 | 8.9 | -1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | nan | |||
| 9935613 | 101293 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 497 | 9 | 1 | 6 | 6.0 | CC1(CCC(=O)O)CC(=O)c2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | |||
| CHEMBL296097 | 101293 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 497 | 9 | 1 | 6 | 6.0 | CC1(CCC(=O)O)CC(=O)c2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | |||
| 10417026 | 93340 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 669 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C(F)(F)F)C(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL24505 | 93340 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 669 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C(F)(F)F)C(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 10348645 | 20680 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| CHEMBL130872 | 20680 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| 9986751 | 116334 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 651 | 13 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2Cc1ccccc1 | 10.1021/jm00055a011 | |||
| CHEMBL335889 | 116334 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 651 | 13 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2Cc1ccccc1 | 10.1021/jm00055a011 | |||
| 15675876 | 177267 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc21 | 10.1021/jm00109a025 | |||
| CHEMBL46343 | 177267 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2ccc(OCc3cccc(OCc4ccc5ccccc5n4)c3)cc21 | 10.1021/jm00109a025 | |||
| 10009390 | 96262 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 645 | 9 | 2 | 6 | 5.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CC(F)(F)C(F)(F)C3)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL26080 | 96262 | None | 0 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 645 | 9 | 2 | 6 | 5.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CC(F)(F)C(F)(F)C3)cc12 | 10.1021/jm00035a008 | |||
| 14626863 | 168014 | None | 1 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL431348 | 168014 | None | 1 | Guinea pig | Binding | pKi | = | 8.9 | 8.9 | -1 | 2 | ChEMBL | 574 | 8 | 3 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 9986283 | 93860 | None | 0 | Guinea pig | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL24758 | 93860 | None | 0 | Guinea pig | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC[C@@H](C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 44352406 | 21521 | None | 0 | Guinea pig | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL131611 | 21521 | None | 0 | Guinea pig | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 10394407 | 95747 | None | 0 | Guinea pig | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 643 | 12 | 2 | 6 | 6.4 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | |||
| CHEMBL25819 | 95747 | None | 0 | Guinea pig | Binding | pKi | = | 8.8 | 8.8 | - | 1 | ChEMBL | 643 | 12 | 2 | 6 | 6.4 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)CC(F)(F)F)ccc21 | 10.1021/jm00035a008 | |||
| 9985579 | 99190 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| CHEMBL281066 | 99190 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| 10348137 | 20137 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.5 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)C)ccc21 | 10.1021/jm00055a011 | |||
| CHEMBL130428 | 20137 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.5 | CCCn1cc(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(C)C)ccc21 | 10.1021/jm00055a011 | |||
| 44285405 | 154479 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1cccc(C(=O)O)c1)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL39876 | 154479 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1cccc(C(=O)O)c1)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| 44285360 | 168390 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 410 | 17 | 3 | 4 | 5.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL434013 | 168390 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 410 | 17 | 3 | 4 | 5.0 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](SCC(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| 44272172 | 66824 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18600 | 66824 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| 9888538 | 66979 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18671 | 66979 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | |||
| 10158419 | 163259 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL418002 | 163259 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 3334 | 3147 | None | 8 | Human | Binding | pKi | = | 8 | 8.0 | -5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | |||
| 60842 | 3147 | None | 8 | Human | Binding | pKi | = | 8 | 8.0 | -5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | |||
| CHEMBL22776 | 3147 | None | 8 | Human | Binding | pKi | = | 8 | 8.0 | -5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | |||
| 10461264 | 21432 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| CHEMBL131507 | 21432 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| 10076815 | 208134 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC3CCCC3)cc21 | 10.1021/jm00055a011 | |||
| CHEMBL82190 | 208134 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1cc(C)c2ccc(C(=O)NCC3CCCC3)cc21 | 10.1021/jm00055a011 | |||
| 15337931 | 208269 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| CHEMBL83267 | 208269 | None | 0 | Guinea pig | Binding | pKi | = | 8 | 8.0 | - | 1 | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| 10348087 | 20817 | None | 0 | Guinea pig | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 573 | 8 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC3CCCCC3)cc12 | 10.1021/jm00055a011 | |||
| CHEMBL130985 | 20817 | None | 0 | Guinea pig | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 573 | 8 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC3CCCCC3)cc12 | 10.1021/jm00055a011 | |||
| 44353486 | 116802 | None | 0 | Guinea pig | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 601 | 9 | 1 | 6 | 5.9 | CCCC1CCN(C(=O)c2ccc3c(c2)c(Cc2ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc2OC)cn3C)CC1 | 10.1021/jm00055a011 | |||
| CHEMBL337473 | 116802 | None | 0 | Guinea pig | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 601 | 9 | 1 | 6 | 5.9 | CCCC1CCN(C(=O)c2ccc3c(c2)c(Cc2ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc2OC)cn3C)CC1 | 10.1021/jm00055a011 | |||
| 3381 | 589 | None | 19 | Guinea pig | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| 5311015 | 589 | None | 19 | Guinea pig | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL285954 | 589 | None | 19 | Guinea pig | Binding | pKi | = | 7 | 7.0 | - | 1 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)Sc1ccc(cc1)C(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| 14406203 | 194579 | None | 0 | Guinea pig | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 322 | 5 | 1 | 4 | 3.2 | CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00128a027 | |||
| CHEMBL52896 | 194579 | None | 0 | Guinea pig | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 322 | 5 | 1 | 4 | 3.2 | CN(O)C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00128a027 | |||
| 13770359 | 69316 | None | 1 | Guinea pig | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 235 | 3 | 0 | 2 | 3.8 | c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | |||
| CHEMBL19281 | 69316 | None | 1 | Guinea pig | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 235 | 3 | 0 | 2 | 3.8 | c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | |||
| 10047878 | 117527 | None | 0 | Guinea pig | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 422 | 9 | 2 | 4 | 4.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)O)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL339897 | 117527 | None | 0 | Guinea pig | Binding | pKi | = | 6 | 6.0 | - | 1 | ChEMBL | 422 | 9 | 2 | 4 | 4.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)O)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 10475982 | 161918 | None | 0 | Guinea pig | Binding | pKi | = | 6 | 6.0 | 15 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | |||
| CHEMBL414462 | 161918 | None | 0 | Guinea pig | Binding | pKi | = | 6 | 6.0 | 15 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | |||
| 129232 | 197204 | None | 21 | Guinea pig | Binding | pKi | = | 4 | 4.0 | - | 1 | ChEMBL | 271 | 5 | 1 | 3 | 2.7 | CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1 | 10.1021/jm00128a027 | |||
| CHEMBL54453 | 197204 | None | 21 | Guinea pig | Binding | pKi | = | 4 | 4.0 | - | 1 | ChEMBL | 271 | 5 | 1 | 3 | 2.7 | CN(O)C(=O)Cc1ccc(OCc2ccccc2)cc1 | 10.1021/jm00128a027 | |||
| 44352444 | 18960 | None | 0 | Guinea pig | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 503 | 8 | 2 | 7 | 4.3 | Cn1cc(CC(=O)NCc2ccc(-c3nn[nH]n3)cc2)c2cc(OCc3ccc4ccccc4n3)ccc21 | 10.1021/jm990387k | |||
| CHEMBL128676 | 18960 | None | 0 | Guinea pig | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 503 | 8 | 2 | 7 | 4.3 | Cn1cc(CC(=O)NCc2ccc(-c3nn[nH]n3)cc2)c2cc(OCc3ccc4ccccc4n3)ccc21 | 10.1021/jm990387k | |||
| 44352153 | 21175 | None | 0 | Guinea pig | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 450 | 8 | 2 | 6 | 4.1 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(Cc2nnn[nH]2)cc1 | 10.1021/jm990387k | |||
| CHEMBL131266 | 21175 | None | 0 | Guinea pig | Binding | pKi | = | 7.0 | 7.0 | - | 1 | ChEMBL | 450 | 8 | 2 | 6 | 4.1 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(Cc2nnn[nH]2)cc1 | 10.1021/jm990387k | |||
| 14742716 | 210473 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 401 | 10 | 1 | 5 | 4.9 | CCCC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00172a024 | |||
| CHEMBL97356 | 210473 | None | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 401 | 10 | 1 | 5 | 4.9 | CCCC(CCc1nnn[nH]1)Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00172a024 | |||
| 14626843 | 101681 | None | 0 | Guinea pig | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 421 | 6 | 3 | 4 | 4.5 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL298939 | 101681 | None | 0 | Guinea pig | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 421 | 6 | 3 | 4 | 4.5 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)NC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 9948371 | 67388 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 303 | 4 | 1 | 5 | 3.0 | c1cc(OCc2ccc3ccccc3n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL18864 | 67388 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 303 | 4 | 1 | 5 | 3.0 | c1cc(OCc2ccc3ccccc3n2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a016 | |||
| 44352451 | 20149 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 476 | 7 | 2 | 4 | 6.4 | CC(C(=O)Nc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL130442 | 20149 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 476 | 7 | 2 | 4 | 6.4 | CC(C(=O)Nc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 9888539 | 64864 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18204 | 64864 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | |||
| 44352414 | 18922 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccccc1-c1nn[nH]n1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL128483 | 18922 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccccc1-c1nn[nH]n1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 10461218 | 100134 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 601 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL287302 | 100134 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 601 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 9985297 | 116725 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 561 | 11 | 2 | 6 | 5.3 | CCC(CC)CNC(=O)c1ccc2ccn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL337058 | 116725 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 561 | 11 | 2 | 6 | 5.3 | CCC(CC)CNC(=O)c1ccc2ccn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 14650365 | 65268 | None | 0 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 375 | 9 | 1 | 6 | 3.5 | c1ccc2nc(COCc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL18273 | 65268 | None | 0 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 375 | 9 | 1 | 6 | 3.5 | c1ccc2nc(COCc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| 14650341 | 98705 | None | 0 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | |||
| CHEMBL277292 | 98705 | None | 0 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | |||
| 105007 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | |||
| CHEMBL267475 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | |||
| CHEMBL267976 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00389a001 | |||
| 11758126 | 116652 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCCCC(CC)NC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| CHEMBL336607 | 116652 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCCCC(CC)NC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| 44285543 | 146925 | None | 0 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 540 | 21 | 3 | 4 | 8.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL39250 | 146925 | None | 0 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | - | 1 | ChEMBL | 540 | 21 | 3 | 4 | 8.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 10203560 | 162924 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2cccc(OCc3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL417271 | 162924 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2cccc(OCc3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 15675883 | 176569 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | |||
| CHEMBL45965 | 176569 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | |||
| 23224640 | 20078 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 514 | 9 | 2 | 6 | 5.5 | O=C(NCCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| CHEMBL130384 | 20078 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 514 | 9 | 2 | 6 | 5.5 | O=C(NCCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| 44352282 | 118517 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| CHEMBL341172 | 118517 | None | 0 | Guinea pig | Binding | pKi | = | 7.9 | 7.9 | - | 1 | ChEMBL | 526 | 9 | 1 | 5 | 5.5 | CN(CCc1ccc(C(=O)O)cc1)S(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| 9927762 | 66298 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL18471 | 66298 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 337 | 8 | 1 | 4 | 4.1 | O=C(O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| 10363485 | 59120 | None | 0 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | 29 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | |||
| CHEMBL169743 | 59120 | None | 0 | Guinea pig | Binding | pKi | = | 5.9 | 5.9 | 29 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | |||
| 44352421 | 21806 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | CC(C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL131934 | 21806 | None | 0 | Guinea pig | Binding | pKi | = | 6.9 | 6.9 | - | 1 | ChEMBL | 504 | 9 | 2 | 4 | 6.0 | CC(C(=O)NCc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 5352624 | 67260 | None | 35 | Human | Binding | pKi | = | 4.8 | 4.8 | -4 | 5 | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | |||
| CHEMBL18797 | 67260 | None | 35 | Human | Binding | pKi | = | 4.8 | 4.8 | -4 | 5 | ChEMBL | 340 | 4 | 1 | 2 | 5.4 | CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1 | nan | |||
| 15675884 | 188048 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | |||
| CHEMBL49696 | 188048 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 479 | 7 | 1 | 8 | 4.6 | O=C1CC(c2nnn[nH]2)Oc2c(COc3ccc(OCc4ccc5ccccc5n4)cc3)cccc21 | 10.1021/jm00109a025 | |||
| 44352162 | 18628 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 629 | 10 | 2 | 6 | 6.4 | Cc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL127665 | 18628 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 629 | 10 | 2 | 6 | 6.4 | Cc1ccccc1S(=O)(=O)NC(=O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 44352411 | 168546 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 487 | 7 | 1 | 6 | 6.3 | O=C(O)c1ccc(Cc2noc(-c3ccc4ccc(OCc5ccc6ccccc6n5)cc4c3)n2)cc1 | 10.1021/jm990387k | |||
| CHEMBL434992 | 168546 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 487 | 7 | 1 | 6 | 6.3 | O=C(O)c1ccc(Cc2noc(-c3ccc4ccc(OCc5ccc6ccccc6n5)cc4c3)n2)cc1 | 10.1021/jm990387k | |||
| 10347819 | 22540 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 561 | 8 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)C)cc12 | 10.1021/jm00055a011 | |||
| CHEMBL132582 | 22540 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 561 | 8 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)C)cc12 | 10.1021/jm00055a011 | |||
| 10415427 | 165681 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C)cc12 | 10.1021/jm00055a011 | |||
| CHEMBL424257 | 165681 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C)cc12 | 10.1021/jm00055a011 | |||
| 15337934 | 107194 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CCc2nnn[nH]2)c2c(c1)CCN2Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/0960-894X(96)00013-3 | |||
| CHEMBL316155 | 107194 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CCc2nnn[nH]2)c2c(c1)CCN2Cc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1016/0960-894X(96)00013-3 | |||
| 19959108 | 208385 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 458 | 7 | 1 | 5 | 5.3 | C(=C/c1ccc2ccccc2n1)\c1cccc(CN2CCc3cccc(CCc4nnn[nH]4)c32)c1 | 10.1016/0960-894X(96)00013-3 | |||
| CHEMBL84150 | 208385 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 458 | 7 | 1 | 5 | 5.3 | C(=C/c1ccc2ccccc2n1)\c1cccc(CN2CCc3cccc(CCc4nnn[nH]4)c32)c1 | 10.1016/0960-894X(96)00013-3 | |||
| 5059 | 208819 | None | 32 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL8747 | 208819 | None | 32 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| 44277861 | 99588 | None | 0 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 395 | 5 | 1 | 3 | 5.7 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2CC[C@H]1Cc1ccccc1 | 10.1016/0960-894X(95)00225-I | |||
| CHEMBL283455 | 99588 | None | 0 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 395 | 5 | 1 | 3 | 5.7 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2CC[C@H]1Cc1ccccc1 | 10.1016/0960-894X(95)00225-I | |||
| 44278542 | 106059 | None | 0 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 440 | 5 | 1 | 5 | 4.4 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1Br | 10.1016/0960-894X(95)00226-J | |||
| CHEMBL31325 | 106059 | None | 0 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | - | 1 | ChEMBL | 440 | 5 | 1 | 5 | 4.4 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1Br | 10.1016/0960-894X(95)00226-J | |||
| 11293119 | 101654 | None | 30 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | |||
| CHEMBL298727 | 101654 | None | 30 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/acs.jmedchem.6b01287 | |||
| 11293119 | 101654 | None | 30 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL298727 | 101654 | None | 30 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 422 | 6 | 2 | 5 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 10158417 | 66741 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18564 | 66741 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 15015299 | 98777 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL277831 | 98777 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 14750536 | 64650 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 331 | 6 | 1 | 5 | 3.1 | c1ccc2nc(COc3ccc(CCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL18177 | 64650 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 331 | 6 | 1 | 5 | 3.1 | c1ccc2nc(COc3ccc(CCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| 9820486 | 67042 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL18703 | 67042 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| 14626829 | 101186 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 423 | 6 | 2 | 6 | 4.4 | COc1cc(C(=O)O)ccc1Cc1nn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL295268 | 101186 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 423 | 6 | 2 | 6 | 4.4 | COc1cc(C(=O)O)ccc1Cc1nn(C)c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 14708733 | 101966 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 408 | 6 | 2 | 5 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | |||
| CHEMBL300940 | 101966 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 408 | 6 | 2 | 5 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | |||
| 9800998 | 99422 | None | 2 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | 32 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | |||
| CHEMBL282524 | 99422 | None | 2 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | 32 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | |||
| 9800998 | 99422 | None | 2 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | 32 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | |||
| CHEMBL282524 | 99422 | None | 2 | Guinea pig | Binding | pKi | = | 5.8 | 5.8 | 32 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | |||
| 2812 | 4781 | None | 63 | Human | Binding | pKi | = | 4.8 | 4.8 | -58 | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
| CHEMBL104 | 4781 | None | 63 | Human | Binding | pKi | = | 4.8 | 4.8 | -58 | 34 | ChEMBL | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | nan | |||
| 44352498 | 18415 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 466 | 6 | 2 | 6 | 4.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | |||
| CHEMBL127162 | 18415 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 466 | 6 | 2 | 6 | 4.9 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | |||
| 14774152 | 67687 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL19072 | 67687 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| 10294833 | 99018 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 407 | 7 | 1 | 5 | 4.8 | c1cc(CCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL279770 | 99018 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 407 | 7 | 1 | 5 | 4.8 | c1cc(CCc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 14650383 | 155931 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCc2ccc3ccccc3n2)ccc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | |||
| CHEMBL406006 | 155931 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCc2ccc3ccccc3n2)ccc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | |||
| 14650346 | 210507 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 359 | 8 | 1 | 5 | 3.9 | c1ccc2nc(COc3ccc(CCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL97541 | 210507 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 359 | 8 | 1 | 5 | 3.9 | c1ccc2nc(COc3ccc(CCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| 44292186 | 101240 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 489 | 7 | 1 | 6 | 5.5 | O=C1CC(C(=O)O)Oc2ccc(Cl)c(OCc3ccc(OCc4ccc5ccccc5n4)cc3)c21 | 10.1021/jm00109a025 | |||
| CHEMBL295664 | 101240 | None | 0 | Guinea pig | Binding | pKi | = | 7.8 | 7.8 | - | 1 | ChEMBL | 489 | 7 | 1 | 6 | 5.5 | O=C1CC(C(=O)O)Oc2ccc(Cl)c(OCc3ccc(OCc4ccc5ccccc5n4)cc3)c21 | 10.1021/jm00109a025 | |||
| 10456871 | 59978 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | O=C(O)CCS[C@@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](O)C(=O)O | 10.1021/jm00389a001 | |||
| CHEMBL173289 | 59978 | None | 0 | Guinea pig | Binding | pKi | = | 6.8 | 6.8 | - | 1 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | O=C(O)CCS[C@@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](O)C(=O)O | 10.1021/jm00389a001 | |||
| 14626841 | 194612 | None | 0 | Guinea pig | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 422 | 9 | 2 | 4 | 5.2 | CCCC(CC)C(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | |||
| CHEMBL52906 | 194612 | None | 0 | Guinea pig | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 422 | 9 | 2 | 4 | 5.2 | CCCC(CC)C(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | |||
| 44352235 | 18967 | None | 0 | Guinea pig | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 552 | 10 | 2 | 4 | 7.8 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL128697 | 18967 | None | 0 | Guinea pig | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 552 | 10 | 2 | 4 | 7.8 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccc(Cl)cc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 14626837 | 101643 | None | 0 | Guinea pig | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 408 | 9 | 2 | 4 | 5.0 | CCCCCC(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | |||
| CHEMBL298642 | 101643 | None | 0 | Guinea pig | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 408 | 9 | 2 | 4 | 5.0 | CCCCCC(=O)Nc1ccc2c(c1)c(Cc1ccc(C(=O)O)cc1OC)cn2C | 10.1021/jm00168a037 | |||
| 44285006 | 151121 | None | 0 | Guinea pig | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 456 | 15 | 3 | 4 | 5.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL39586 | 151121 | None | 0 | Guinea pig | Binding | pKi | = | 4.7 | 4.7 | - | 1 | ChEMBL | 456 | 15 | 3 | 4 | 5.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/s0960-894x(99)00461-8 | |||
| 15015283 | 67037 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1ccc(OCc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18699 | 67037 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1ccc(OCc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | |||
| 15675878 | 187651 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| CHEMBL49449 | 187651 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| 1836 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | |||
| 3340 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | |||
| 5281040 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | |||
| 5281040.0 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | |||
| CHEMBL787 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | |||
| DB00471 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | 1 | 15 | ChEMBL | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 10.1021/jm990387k | |||
| 10100314 | 100081 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 613 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC/C(C)=C\C(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL286885 | 100081 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 613 | 9 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NC/C(C)=C\C(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 10114089 | 67394 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc(OCc3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18866 | 67394 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(OCc2ccc(OCc3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 10223216 | 67486 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18918 | 67486 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| 10349047 | 96722 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 629 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL26384 | 96722 | None | 0 | Guinea pig | Binding | pKi | = | 8.7 | 8.7 | - | 1 | ChEMBL | 629 | 10 | 2 | 6 | 5.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)(C)CC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | -1 | 6 | ChEMBL | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 10.1016/0960-894X(95)00227-K | |||
| 44214127 | 18892 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 526 | 10 | 2 | 5 | 5.1 | O=C(O)Cc1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL128317 | 18892 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 526 | 10 | 2 | 5 | 5.1 | O=C(O)Cc1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 10484810 | 96122 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 693 | 11 | 2 | 6 | 6.4 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3Br)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | |||
| CHEMBL26002 | 96122 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 693 | 11 | 2 | 6 | 6.4 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3Br)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | |||
| 22241529 | 68255 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 457 | 8 | 1 | 6 | 5.2 | Clc1ccc2ccc(COc3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | |||
| CHEMBL19158 | 68255 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 457 | 8 | 1 | 6 | 5.2 | Clc1ccc2ccc(COc3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | |||
| 44272197 | 167127 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 453 | 7 | 1 | 5 | 5.7 | Clc1ccc2ccc(/C=C/c3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | |||
| CHEMBL428868 | 167127 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 453 | 7 | 1 | 5 | 5.7 | Clc1ccc2ccc(/C=C/c3ccc(OCc4ccccc4Cc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a017 | |||
| 15675872 | 179471 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 475 | 6 | 1 | 7 | 5.2 | O=C1CC(c2nnn[nH]2)Oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| CHEMBL47376 | 179471 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 475 | 6 | 1 | 7 | 5.2 | O=C1CC(c2nnn[nH]2)Oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc21 | 10.1021/jm00109a025 | |||
| 14842364 | 123187 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 473 | 6 | 1 | 7 | 5.3 | O=c1cc(-c2nn[nH]n2)oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | |||
| CHEMBL36113 | 123187 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 473 | 6 | 1 | 7 | 5.3 | O=c1cc(-c2nn[nH]n2)oc2cc(/C=C/c3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | |||
| 10372164 | 24014 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 657 | 13 | 2 | 6 | 7.4 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL133788 | 24014 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 657 | 13 | 2 | 6 | 7.4 | CCC(CC)CNC(=O)c1ccc2c(CC3CCCCC3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 10077724 | 23547 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 629 | 12 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C1CCCC1 | 10.1021/jm00055a011 | |||
| CHEMBL133398 | 23547 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 629 | 12 | 2 | 6 | 6.9 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C1CCCC1 | 10.1021/jm00055a011 | |||
| 10348138 | 168396 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.6 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL434053 | 168396 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.6 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 10075131 | 18939 | None | 2 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 512 | 9 | 2 | 5 | 5.2 | O=C(O)c1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL128583 | 18939 | None | 2 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 512 | 9 | 2 | 5 | 5.2 | O=C(O)c1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 9804436 | 20646 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL130846 | 20646 | None | 0 | Guinea pig | Binding | pKi | = | 8.6 | 8.6 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1ccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 15015300 | 98559 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL276136 | 98559 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2ccc(-c3nn[nH]n3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 10158418 | 66164 | None | 0 | Guinea pig | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18413 | 66164 | None | 0 | Guinea pig | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2ccccc2-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| 9870702 | 100335 | None | 14 | Guinea pig | Binding | pKi | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 502 | 6 | 0 | 5 | 7.7 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | |||
| CHEMBL28902 | 100335 | None | 14 | Guinea pig | Binding | pKi | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 502 | 6 | 0 | 5 | 7.7 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccc(Cl)cc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | |||
| 14708738 | 189807 | None | 0 | Guinea pig | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 406 | 7 | 2 | 4 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | |||
| CHEMBL51544 | 189807 | None | 0 | Guinea pig | Binding | pKi | = | 6.7 | 6.7 | - | 1 | ChEMBL | 406 | 7 | 2 | 4 | 4.9 | COc1cc(C(=O)O)ccc1Cn1ccc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | |||
| 44352288 | 117411 | None | 0 | Guinea pig | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL339716 | 117411 | None | 0 | Guinea pig | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 477 | 10 | 1 | 4 | 7.1 | O=C(O)c1ccc(CCCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 10225194 | 65287 | None | 0 | Guinea pig | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a017 | |||
| CHEMBL18281 | 65287 | None | 0 | Guinea pig | Binding | pKi | = | 7.7 | 7.7 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1OCc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a017 | |||
| 105007 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | |||
| CHEMBL267475 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | |||
| CHEMBL267976 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 5.7 | 5.7 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00147a004 | |||
| 42611190 | 3156 | None | 14 | Human | Binding | pKi | = | 6.6 | 6.6 | -575 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| 5802 | 3156 | None | 14 | Human | Binding | pKi | = | 6.6 | 6.6 | -575 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| CHEMBL1800685 | 3156 | None | 14 | Human | Binding | pKi | = | 6.6 | 6.6 | -575 | 22 | ChEMBL | 475 | 4 | 2 | 2 | 7.4 | OC(=O)c1cc2cc(ccc2c(c1)c1ccc(cc1)C1CCNCC1)c1ccc(cc1)C(F)(F)F | 10.6019/CHEMBL4507292 | |||
| 44277896 | 101741 | None | 1 | Guinea pig | Binding | pKi | = | 4.6 | 4.6 | - | 1 | ChEMBL | 382 | 5 | 1 | 5 | 4.0 | O[C@@H]1c2cc(OCc3cccc(Cl)n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | |||
| CHEMBL29937 | 101741 | None | 1 | Guinea pig | Binding | pKi | = | 4.6 | 4.6 | - | 1 | ChEMBL | 382 | 5 | 1 | 5 | 4.0 | O[C@@H]1c2cc(OCc3cccc(Cl)n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00226-J | |||
| 14626844 | 188992 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 408 | 6 | 3 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL50733 | 188992 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 408 | 6 | 3 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1c[nH]c2ccc(NC(=O)OC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 44352209 | 18935 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 482 | 8 | 2 | 5 | 4.6 | O=C(O)c1ccc(CCNC(=O)C2CCc3ccc(OCc4ccc5ccccc5n4)cc3O2)cc1 | 10.1021/jm990387k | |||
| CHEMBL128548 | 18935 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 482 | 8 | 2 | 5 | 4.6 | O=C(O)c1ccc(CCNC(=O)C2CCc3ccc(OCc4ccc5ccccc5n4)cc3O2)cc1 | 10.1021/jm990387k | |||
| 14650373 | 64198 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 367 | 8 | 1 | 7 | 3.4 | c1ccc2sc(COc3ccc(OCCCc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL18085 | 64198 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 367 | 8 | 1 | 7 | 3.4 | c1ccc2sc(COc3ccc(OCCCc4nnn[nH]4)cc3)nc2c1 | 10.1021/jm00166a016 | |||
| 14650381 | 65560 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 389 | 9 | 1 | 6 | 3.9 | CCc1ccc(OCc2ccc3ccccc3n2)cc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | |||
| CHEMBL18309 | 65560 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 389 | 9 | 1 | 6 | 3.9 | CCc1ccc(OCc2ccc3ccccc3n2)cc1OCCCc1nnn[nH]1 | 10.1021/jm00166a016 | |||
| 10001437 | 99638 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 407 | 6 | 1 | 7 | 3.6 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1[N+](=O)[O-] | 10.1016/0960-894X(95)00226-J | |||
| CHEMBL283886 | 99638 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 407 | 6 | 1 | 7 | 3.6 | Cc1nc(COc2ccc3c(c2)[C@@H](O)[C@@H](Cc2cccnc2)CO3)ccc1[N+](=O)[O-] | 10.1016/0960-894X(95)00226-J | |||
| 9956127 | 169484 | None | 13 | Guinea pig | Binding | pKi | = | 4.6 | 4.6 | - | 1 | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/0960-894X(95)00225-I | |||
| CHEMBL442150 | 169484 | None | 13 | Guinea pig | Binding | pKi | = | 4.6 | 4.6 | - | 1 | ChEMBL | 465 | 6 | 2 | 6 | 5.0 | O=C(O)c1cccc(C[C@@H]2COc3ccc(OCc4nc5cc(F)ccc5s4)cc3[C@@H]2O)c1 | 10.1016/0960-894X(95)00225-I | |||
| 126145 | 47867 | None | 1 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 488 | 18 | 2 | 4 | 7.2 | O=C(O)CCSC(SCCC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00147a004 | |||
| CHEMBL15489 | 47867 | None | 1 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 488 | 18 | 2 | 4 | 7.2 | O=C(O)CCSC(SCCC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00147a004 | |||
| 10258882 | 116588 | None | 0 | Guinea pig | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 665 | 14 | 2 | 6 | 7.1 | CCC(CC)CNC(=O)c1ccc2c(CCc3ccccc3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL336194 | 116588 | None | 0 | Guinea pig | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 665 | 14 | 2 | 6 | 7.1 | CCC(CC)CNC(=O)c1ccc2c(CCc3ccccc3)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 44285389 | 100039 | None | 0 | Guinea pig | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1ccccc1C(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL286626 | 100039 | None | 0 | Guinea pig | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C\C=C\C=C\[C@@H](Sc1ccccc1C(=O)O)[C@@H](O)CCCC(=O)O | 10.1016/S0960-894X(00)80009-8 | |||
| 10345753 | 208422 | None | 0 | Guinea pig | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| CHEMBL84552 | 208422 | None | 0 | Guinea pig | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 496 | 8 | 1 | 6 | 5.3 | Clc1ccc2ccc(COc3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| 44352484 | 21495 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | |||
| CHEMBL131582 | 21495 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 450 | 8 | 2 | 6 | 3.9 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | |||
| 44285277 | 154851 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 512 | 19 | 3 | 4 | 7.4 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL40009 | 154851 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 512 | 19 | 3 | 4 | 7.4 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 44353198 | 20780 | None | 0 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 422 | 9 | 2 | 4 | 4.7 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | |||
| CHEMBL130948 | 20780 | None | 0 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 422 | 9 | 2 | 4 | 4.7 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | |||
| 44352125 | 117289 | None | 0 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 469 | 13 | 2 | 5 | 5.0 | O=C(Cc1ccc(OCCCCc2ccccc2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | |||
| CHEMBL339461 | 117289 | None | 0 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 469 | 13 | 2 | 5 | 5.0 | O=C(Cc1ccc(OCCCCc2ccccc2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | |||
| 9948863 | 68044 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 317 | 5 | 1 | 5 | 2.9 | c1ccc2nc(COc3ccc(Cc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL19136 | 68044 | None | 0 | Guinea pig | Binding | pKi | = | 6.6 | 6.6 | - | 1 | ChEMBL | 317 | 5 | 1 | 5 | 2.9 | c1ccc2nc(COc3ccc(Cc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| 23224681 | 19493 | None | 0 | Guinea pig | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL129893 | 19493 | None | 0 | Guinea pig | Binding | pKi | = | 7.6 | 7.6 | - | 1 | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 14836105 | 12077 | None | 0 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | |||
| CHEMBL1183712 | 12077 | None | 0 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | |||
| CHEMBL314449 | 12077 | None | 0 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 357 | 5 | 1 | 3 | 5.2 | C[C@H](C(=O)O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm00092a001 | |||
| 3969 | 55918 | None | 31 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00168a037 | |||
| CHEMBL162358 | 55918 | None | 31 | Guinea pig | Binding | pKi | = | 5.6 | 5.6 | - | 1 | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00168a037 | |||
| 44352119 | 20833 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL131008 | 20833 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1cccc(-c2nn[nH]n2)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 44352157 | 19452 | None | 0 | Guinea pig | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 468 | 10 | 1 | 4 | 5.4 | CN(C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1)c1ccc(CCCC(=O)O)cc1 | 10.1021/jm990387k | |||
| CHEMBL129570 | 19452 | None | 0 | Guinea pig | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 468 | 10 | 1 | 4 | 5.4 | CN(C(=O)Cc1ccc(OCc2ccc3ccccc3n2)cc1)c1ccc(CCCC(=O)O)cc1 | 10.1021/jm990387k | |||
| 129044 | 66420 | None | 26 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18518 | 66420 | None | 26 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00166a017 | |||
| 129044 | 66420 | None | 26 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00109a025 | |||
| CHEMBL18518 | 66420 | None | 26 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00109a025 | |||
| 10050711 | 110438 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 477 | 7 | 1 | 8 | 4.7 | O=c1cc(-c2nn[nH]n2)oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | |||
| CHEMBL32426 | 110438 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 477 | 7 | 1 | 8 | 4.7 | O=c1cc(-c2nn[nH]n2)oc2cc(OCc3cccc(OCc4ccc5ccccc5n4)c3)ccc12 | 10.1021/jm970180w | |||
| 129044 | 66420 | None | 26 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00108a001 | |||
| CHEMBL18518 | 66420 | None | 26 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc(Cc2nn[nH]n2)c(COc2ccc(OCc3ccc4ccccc4n3)cc2)c1 | 10.1021/jm00108a001 | |||
| 10438378 | 20999 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| CHEMBL131148 | 20999 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 589 | 12 | 2 | 6 | 5.9 | CCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| 10438054 | 92240 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00055a011 | |||
| CHEMBL24256 | 92240 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00055a011 | |||
| 10438054 | 92240 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL24256 | 92240 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 573 | 9 | 2 | 6 | 5.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3CCCC3)cc12 | 10.1021/jm00035a008 | |||
| 10223827 | 98520 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 419 | 7 | 1 | 5 | 5.1 | C(=C/c1ccc2ccccc2n1)\c1ccc(OCc2ccccc2Cc2nnn[nH]2)cc1 | 10.1021/jm00166a017 | |||
| CHEMBL275866 | 98520 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 419 | 7 | 1 | 5 | 5.1 | C(=C/c1ccc2ccccc2n1)\c1ccc(OCc2ccccc2Cc2nnn[nH]2)cc1 | 10.1021/jm00166a017 | |||
| 10074704 | 165400 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| CHEMBL423333 | 165400 | None | 0 | Guinea pig | Binding | pKi | = | 8.5 | 8.5 | - | 1 | ChEMBL | 500 | 8 | 2 | 6 | 5.1 | O=C(NCCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| 44352452 | 18955 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1021/jm990387k | |||
| CHEMBL128641 | 18955 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 540 | 9 | 2 | 5 | 5.9 | CC(C)(CNS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccc(C(=O)O)cc1 | 10.1021/jm990387k | |||
| 10348808 | 96658 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 613 | 10 | 2 | 6 | 5.4 | C=C(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | |||
| CHEMBL26332 | 96658 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 613 | 10 | 2 | 6 | 5.4 | C=C(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | |||
| 44353313 | 116530 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 639 | 11 | 2 | 6 | 6.1 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Br)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL336101 | 116530 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 639 | 11 | 2 | 6 | 6.1 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Br)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 44353268 | 116726 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 589 | 13 | 2 | 6 | 5.9 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| CHEMBL337059 | 116726 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 589 | 13 | 2 | 6 | 5.9 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| 44292483 | 175934 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 483 | 8 | 0 | 7 | 5.3 | CCOC(=O)C1CC(=O)c2ccc(COc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | |||
| CHEMBL45850 | 175934 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 483 | 8 | 0 | 7 | 5.3 | CCOC(=O)C1CC(=O)c2ccc(COc3cccc(OCc4ccc5ccccc5n4)c3)cc2O1 | 10.1021/jm00109a025 | |||
| 44352385 | 18981 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 516 | 6 | 2 | 6 | 6.0 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| CHEMBL128771 | 18981 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 516 | 6 | 2 | 6 | 6.0 | O=C(Nc1cccc2c(=O)cc(C(=O)O)oc12)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| 44352384 | 19363 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 458 | 6 | 1 | 4 | 6.7 | O=C(O)c1ccc2c(ccn2Cc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | |||
| CHEMBL129079 | 19363 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 458 | 6 | 1 | 4 | 6.7 | O=C(O)c1ccc2c(ccn2Cc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | |||
| 44352326 | 20855 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL131025 | 20855 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 490 | 9 | 2 | 4 | 6.6 | O=C(O)CCCc1ccc(NC(=O)c2ccc3cc(OCc4ccc5ccccc5n4)ccc3c2)cc1 | 10.1021/jm990387k | |||
| 10223215 | 65633 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1ccc2nc(COc3ccc(COc4ccc(-c5nn[nH]n5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | |||
| CHEMBL18339 | 65633 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1ccc2nc(COc3ccc(COc4ccc(-c5nn[nH]n5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | |||
| 14650348 | 65250 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(COc3ccc(SCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL18265 | 65250 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(COc3ccc(SCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| 14650342 | 98910 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 476 | 10 | 1 | 6 | 4.5 | O=C(CCCOc1ccc(OCc2ccc3ccccc3n2)cc1)NS(=O)(=O)c1ccccc1 | 10.1021/jm00166a016 | |||
| CHEMBL278920 | 98910 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 476 | 10 | 1 | 6 | 4.5 | O=C(CCCOc1ccc(OCc2ccc3ccccc3n2)cc1)NS(=O)(=O)c1ccccc1 | 10.1021/jm00166a016 | |||
| 15337938 | 208368 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| CHEMBL84025 | 208368 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3ccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)cc3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| 44285563 | 153541 | None | 0 | Guinea pig | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 528 | 20 | 3 | 5 | 7.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL39794 | 153541 | None | 0 | Guinea pig | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 528 | 20 | 3 | 5 | 7.2 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 44285014 | 162736 | None | 0 | Guinea pig | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 498 | 18 | 3 | 4 | 7.0 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL416973 | 162736 | None | 0 | Guinea pig | Binding | pKi | = | 6.5 | 6.5 | - | 1 | ChEMBL | 498 | 18 | 3 | 4 | 7.0 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 14501729 | 66242 | None | 0 | Guinea pig | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc(OCc2ccc3ccccc3n2)c(OCCCc2nnn[nH]2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL18450 | 66242 | None | 0 | Guinea pig | Binding | pKi | = | 5.5 | 5.5 | - | 1 | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc(OCc2ccc3ccccc3n2)c(OCCCc2nnn[nH]2)c1 | 10.1021/jm00166a016 | |||
| 9848518 | 107346 | None | 12 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | 1 | 2 | ChEMBL | 492 | 6 | 0 | 6 | 7.2 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3nc4cc(F)ccc4s3)c2)cc1 | 10.1016/0960-894X(95)00227-K | |||
| CHEMBL31714 | 107346 | None | 12 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | 1 | 2 | ChEMBL | 492 | 6 | 0 | 6 | 7.2 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3nc4cc(F)ccc4s3)c2)cc1 | 10.1016/0960-894X(95)00227-K | |||
| 44352109 | 116747 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 516 | 8 | 4 | 7 | 5.2 | CC(C(=O)Nc1ccc(CC2=NNNN2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL337162 | 116747 | None | 0 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 516 | 8 | 4 | 7 | 5.2 | CC(C(=O)Nc1ccc(CC2=NNNN2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 60539 | 60011 | None | 14 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00166a017 | |||
| CHEMBL17344 | 60011 | None | 14 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00166a017 | |||
| 60539 | 60011 | None | 14 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00108a001 | |||
| CHEMBL17344 | 60011 | None | 14 | Guinea pig | Binding | pKi | = | 7.5 | 7.5 | - | 1 | ChEMBL | 382 | 5 | 1 | 4 | 4.1 | O=S(=O)(Nc1cccc(OCc2ccc3ccccc3n2)c1)C(F)(F)F | 10.1021/jm00108a001 | |||
| 44352450 | 19486 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL129866 | 19486 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.3 | CC(C(=O)Nc1ccc(CC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 44352264 | 18929 | None | 0 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 456 | 10 | 2 | 4 | 5.4 | CC(C(=O)NCCCCC(=O)O)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL128531 | 18929 | None | 0 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 456 | 10 | 2 | 4 | 5.4 | CC(C(=O)NCCCCC(=O)O)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 129968 | 163350 | None | 15 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL418551 | 163350 | None | 15 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| 44352354 | 18862 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 518 | 10 | 2 | 4 | 7.1 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL128164 | 18862 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 518 | 10 | 2 | 4 | 7.1 | CC(C(=O)Nc1ccc(CCCC(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 14650340 | 67205 | None | 0 | Guinea pig | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 307 | 7 | 0 | 3 | 5.0 | CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL18775 | 67205 | None | 0 | Guinea pig | Binding | pKi | = | 5.4 | 5.4 | - | 1 | ChEMBL | 307 | 7 | 0 | 3 | 5.0 | CCCCOc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| 44352172 | 116611 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 495 | 10 | 2 | 6 | 5.5 | O=C(O)c1ccc(OCC(O)COc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL336298 | 116611 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 495 | 10 | 2 | 6 | 5.5 | O=C(O)c1ccc(OCC(O)COc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 44352462 | 115442 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| CHEMBL335000 | 115442 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(Cc1ccc(C(=O)O)cc1)NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| 10394121 | 99844 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 621 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | |||
| CHEMBL285300 | 99844 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 621 | 10 | 2 | 6 | 5.8 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | |||
| 15015281 | 66797 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1COc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18589 | 66797 | None | 0 | Guinea pig | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(-c2nn[nH]n2)ccc1COc1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 44352294 | 163536 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | |||
| CHEMBL419796 | 163536 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.4 | O=C(O)c1cccc(CCOCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)c1 | 10.1021/jm990387k | |||
| 10416524 | 93341 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 627 | 10 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3(CC(F)(F)F)CC3)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL24506 | 93341 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 627 | 10 | 2 | 6 | 5.7 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC3(CC(F)(F)F)CC3)cc12 | 10.1021/jm00035a008 | |||
| 9985579 | 99190 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | |||
| CHEMBL281066 | 99190 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | |||
| 9870130 | 19001 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 488 | 10 | 2 | 4 | 6.1 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2)cc1 | 10.1021/jm990387k | |||
| CHEMBL128794 | 19001 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 488 | 10 | 2 | 4 | 6.1 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccc(Cl)cc4n3)cc2)cc1 | 10.1021/jm990387k | |||
| 10416647 | 99678 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 635 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | |||
| CHEMBL284128 | 99678 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 635 | 10 | 2 | 6 | 6.1 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2Cl)ccc1Cn1cc(C)c2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | |||
| 9952064 | 67574 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1cccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18979 | 67574 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1cccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c1 | 10.1021/jm00166a017 | |||
| 44352118 | 21275 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL131345 | 21275 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm990387k | |||
| 6917955 | 79948 | None | 0 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc([C@@H](O)[C@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| CHEMBL21247 | 79948 | None | 0 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc([C@@H](O)[C@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| 44286706 | 14622 | None | 0 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | |||
| CHEMBL1205015 | 14622 | None | 0 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | |||
| CHEMBL41301 | 14622 | None | 0 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | |||
| 14626846 | 188801 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 466 | 9 | 2 | 6 | 5.1 | COCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | |||
| CHEMBL50422 | 188801 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 466 | 9 | 2 | 6 | 5.1 | COCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | |||
| 44382463 | 59242 | None | 0 | Guinea pig | Binding | pKi | = | 5.4 | 5.4 | 9 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | |||
| CHEMBL170226 | 59242 | None | 0 | Guinea pig | Binding | pKi | = | 5.4 | 5.4 | 9 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2ccc(OCc3ccc4ccccc4n3)cc2OC[C@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00135-G | |||
| 129968 | 163350 | None | 15 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL418551 | 163350 | None | 15 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| 44352142 | 18860 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | |||
| CHEMBL128151 | 18860 | None | 0 | Guinea pig | Binding | pKi | = | 7.4 | 7.4 | - | 1 | ChEMBL | 454 | 10 | 2 | 4 | 5.2 | O=C(O)CCCc1ccc(C(=O)NCc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | |||
| 126144 | 46417 | None | 1 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 468 | 20 | 2 | 4 | 7.6 | CCCCCCCCCCCCc1ccccc1C(SCCC(=O)O)SCCC(=O)O | 10.1021/jm00147a004 | |||
| CHEMBL15367 | 46417 | None | 1 | Guinea pig | Binding | pKi | = | 6.4 | 6.4 | - | 1 | ChEMBL | 468 | 20 | 2 | 4 | 7.6 | CCCCCCCCCCCCc1ccccc1C(SCCC(=O)O)SCCC(=O)O | 10.1021/jm00147a004 | |||
| 3334 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | |||
| 60842 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | |||
| CHEMBL22776 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00389a001 | |||
| 3334 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | |||
| 60842 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | |||
| CHEMBL22776 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00108a001 | |||
| 3334 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | |||
| 60842 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | |||
| CHEMBL22776 | 3147 | None | 8 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 5 | 2 | ChEMBL | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 10.1021/jm00168a037 | |||
| 10461845 | 100071 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 643 | 12 | 2 | 6 | 6.3 | CCCCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)C(F)(F)F | 10.1021/jm00035a008 | |||
| CHEMBL286827 | 100071 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 643 | 12 | 2 | 6 | 6.3 | CCCCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)C(F)(F)F | 10.1021/jm00035a008 | |||
| 14948496 | 93533 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| CHEMBL24613 | 93533 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| 9870316 | 208210 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| CHEMBL82758 | 208210 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 492 | 7 | 1 | 5 | 5.9 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(CCc6nnn[nH]6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| 15337936 | 208376 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 494 | 7 | 1 | 6 | 5.7 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(OCc6nn[nH]n6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| CHEMBL84089 | 208376 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 494 | 7 | 1 | 6 | 5.7 | Clc1ccc2ccc(/C=C/c3cccc(CN4CCc5cccc(OCc6nn[nH]n6)c54)c3)nc2c1 | 10.1016/0960-894X(96)00013-3 | |||
| 14948496 | 93533 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | |||
| CHEMBL24613 | 93533 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 561 | 10 | 2 | 6 | 5.0 | CCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00035a008 | |||
| 9909426 | 67321 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18833 | 67321 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 409 | 7 | 1 | 6 | 4.6 | c1cc(COc2cccc(-c3nn[nH]n3)c2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 10031940 | 19484 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 629 | 11 | 2 | 6 | 5.9 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | |||
| CHEMBL12985 | 19484 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 629 | 11 | 2 | 6 | 5.9 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C)CC(F)(F)F | 10.1021/jm00035a008 | |||
| 10394230 | 61065 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC)C(F)(F)F | 10.1021/jm00035a008 | |||
| CHEMBL176286 | 61065 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 629 | 11 | 2 | 6 | 6.0 | CCC(CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2CC)C(F)(F)F | 10.1021/jm00035a008 | |||
| 10481103 | 18846 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 500 | 8 | 2 | 6 | 5.0 | O=C(Cc1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | |||
| CHEMBL128068 | 18846 | None | 0 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 500 | 8 | 2 | 6 | 5.0 | O=C(Cc1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1)NCc1ccc(-c2nn[nH]n2)cc1 | 10.1021/jm990387k | |||
| 9847235 | 21227 | None | 2 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.7 | O=C(O)c1ccc(CCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL131304 | 21227 | None | 2 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | - | 1 | ChEMBL | 463 | 9 | 1 | 4 | 6.7 | O=C(O)c1ccc(CCCOc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 14708752 | 187793 | None | 0 | Guinea pig | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 407 | 7 | 2 | 5 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | |||
| CHEMBL49519 | 187793 | None | 0 | Guinea pig | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 407 | 7 | 2 | 5 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)CC3CCCC3)cc21 | 10.1021/jm00168a037 | |||
| 10371402 | 21435 | None | 0 | Guinea pig | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 601 | 12 | 2 | 6 | 6.3 | C/C=C\c1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| CHEMBL131514 | 21435 | None | 0 | Guinea pig | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 601 | 12 | 2 | 6 | 6.3 | C/C=C\c1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| 9890545 | 208340 | None | 0 | Guinea pig | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CN2CCc3cccc(CCc4nnn[nH]4)c32)cc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(96)00013-3 | |||
| CHEMBL83851 | 208340 | None | 0 | Guinea pig | Binding | pKi | = | 7.3 | 7.3 | - | 1 | ChEMBL | 462 | 8 | 1 | 6 | 4.7 | c1cc(CN2CCc3cccc(CCc4nnn[nH]4)c32)cc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(96)00013-3 | |||
| 14650371 | 66268 | None | 0 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 362 | 8 | 1 | 7 | 2.7 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ncc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL18459 | 66268 | None | 0 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 362 | 8 | 1 | 7 | 2.7 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ncc2c1 | 10.1021/jm00166a016 | |||
| 9951001 | 66334 | None | 0 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | |||
| CHEMBL18490 | 66334 | None | 0 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 365 | 9 | 0 | 5 | 4.5 | CCOC(=O)CCCOc1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm00166a016 | |||
| 44285448 | 121170 | None | 0 | Guinea pig | Binding | pKi | = | 5.3 | 5.3 | - | 1 | ChEMBL | 568 | 23 | 3 | 4 | 8.9 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL35731 | 121170 | None | 0 | Guinea pig | Binding | pKi | = | 5.3 | 5.3 | - | 1 | ChEMBL | 568 | 23 | 3 | 4 | 8.9 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCCCCCCc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 105007 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | |||
| CHEMBL267475 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | |||
| CHEMBL267976 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a017 | |||
| 105007 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | |||
| CHEMBL267475 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | |||
| CHEMBL267976 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00109a025 | |||
| 14650359 | 67913 | None | 0 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(CSc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL19106 | 67913 | None | 0 | Guinea pig | Binding | pKi | = | 6.3 | 6.3 | - | 1 | ChEMBL | 377 | 8 | 1 | 6 | 4.1 | c1ccc2nc(CSc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| 6518171 | 168399 | None | 38 | Human | Binding | pKi | = | 5.3 | 5.3 | -4 | 8 | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | |||
| CHEMBL434063 | 168399 | None | 38 | Human | Binding | pKi | = | 5.3 | 5.3 | -4 | 8 | ChEMBL | 495 | 12 | 2 | 6 | 4.9 | CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 | nan | |||
| 14626845 | 165019 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 450 | 8 | 2 | 5 | 5.8 | CCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | |||
| CHEMBL422404 | 165019 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 450 | 8 | 2 | 5 | 5.8 | CCCn1cc(Cc2ccc(C(=O)O)cc2OC)c2cc(NC(=O)OC3CCCC3)ccc21 | 10.1021/jm00168a037 | |||
| 44352130 | 21429 | None | 0 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 464 | 9 | 2 | 6 | 4.8 | O=C(Nc1ccc(CCCc2nnn[nH]2)cc1)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | |||
| CHEMBL131502 | 21429 | None | 0 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 464 | 9 | 2 | 6 | 4.8 | O=C(Nc1ccc(CCCc2nnn[nH]2)cc1)c1ccc(OCc2ccc3ccccc3n2)cc1 | 10.1021/jm990387k | |||
| 15675886 | 101197 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(COc3ccc(OCc4ccc5ccccc5n4)cc3)ccc21 | 10.1021/jm00109a025 | |||
| CHEMBL295368 | 101197 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 455 | 7 | 1 | 6 | 4.8 | O=C1CC(C(=O)O)Oc2cc(COc3ccc(OCc4ccc5ccccc5n4)cc3)ccc21 | 10.1021/jm00109a025 | |||
| 10482604 | 19780 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 547 | 9 | 2 | 6 | 4.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C)cc12 | 10.1021/jm00055a011 | |||
| CHEMBL130140 | 19780 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 547 | 9 | 2 | 6 | 4.6 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCC(C)C)cc12 | 10.1021/jm00055a011 | |||
| 44353314 | 23636 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 595 | 11 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Cl)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL133462 | 23636 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 595 | 11 | 2 | 6 | 5.9 | CCC(CC)CNC(=O)c1ccc2c(C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4Cl)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 10438821 | 117544 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 617 | 13 | 2 | 6 | 6.5 | CCC(CC)CNC(=O)c1ccc2c(CC(C)C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| CHEMBL339958 | 117544 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 617 | 13 | 2 | 6 | 6.5 | CCC(CC)CNC(=O)c1ccc2c(CC(C)C)cn(Cc3ccc(C(=O)NS(=O)(=O)c4ccccc4C)cc3OC)c2c1 | 10.1021/jm00055a011 | |||
| 10325810 | 22396 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| CHEMBL132449 | 22396 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 575 | 11 | 2 | 6 | 5.4 | CCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| 10461263 | 161831 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| CHEMBL413742 | 161831 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 603 | 13 | 2 | 6 | 6.2 | CCCCC(CC)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| 6436135 | 99626 | None | 31 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | 10.1021/jm970180w | |||
| CHEMBL283754 | 99626 | None | 31 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | 10.1021/jm970180w | |||
| 9803418 | 60490 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCSC(CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00389a001 | |||
| CHEMBL175401 | 60490 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCSC(CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00389a001 | |||
| 9868007 | 81481 | None | 4 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCS[C@@H](CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00108a001 | |||
| CHEMBL21595 | 81481 | None | 4 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 442 | 16 | 2 | 3 | 6.5 | O=C(O)CCS[C@@H](CC(=O)O)c1ccccc1CCCCCCCCc1ccccc1 | 10.1021/jm00108a001 | |||
| 3969 | 55918 | None | 31 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00092a001 | |||
| CHEMBL162358 | 55918 | None | 31 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00092a001 | |||
| 3969 | 55918 | None | 31 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| CHEMBL162358 | 55918 | None | 31 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 318 | 9 | 2 | 6 | 2.5 | CCCc1c(OCCCCc2nnn[nH]2)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| 10437821 | 116586 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 561 | 9 | 1 | 6 | 4.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)N(C)CC(C)C)cc12 | 10.1021/jm00055a011 | |||
| CHEMBL336183 | 116586 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 561 | 9 | 1 | 6 | 4.9 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)N(C)CC(C)C)cc12 | 10.1021/jm00055a011 | |||
| 10026794 | 20207 | None | 0 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 450 | 11 | 2 | 4 | 5.5 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| CHEMBL130495 | 20207 | None | 0 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 450 | 11 | 2 | 4 | 5.5 | CCCc1cn(Cc2ccc(C(=O)O)cc2OC)c2cc(C(=O)NCC(CC)CC)ccc12 | 10.1021/jm00055a011 | |||
| 44285289 | 100551 | None | 0 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 514 | 19 | 3 | 5 | 6.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| CHEMBL291032 | 100551 | None | 0 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 514 | 19 | 3 | 5 | 6.8 | O=C(O)CCC[C@H](O)[C@@H](/C=C\CCCCCCCCOc1ccccc1)Sc1ccc(C(=O)O)cc1 | 10.1016/S0960-894X(00)80009-8 | |||
| 9885950 | 98445 | None | 0 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL275385 | 98445 | None | 0 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | - | 1 | ChEMBL | 375 | 8 | 1 | 6 | 3.6 | Cc1cc(OCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| 9800998 | 99422 | None | 2 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | 32 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00225-I | |||
| CHEMBL282524 | 99422 | None | 2 | Guinea pig | Binding | pKi | = | 6.2 | 6.2 | 32 | 2 | ChEMBL | 398 | 5 | 1 | 5 | 4.5 | O[C@@H]1c2cc(OCc3ccc4ccccc4n3)ccc2OC[C@@H]1Cc1cccnc1 | 10.1016/0960-894X(95)00225-I | |||
| 44352422 | 116651 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1cccc(C(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL336606 | 116651 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1cccc(C(=O)O)c1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 10808580 | 100222 | None | 0 | Guinea pig | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 361 | 6 | 1 | 3 | 5.6 | CCCCC1CCc2ccc(OCc3ccc4ccccc4n3)cc2C1O | 10.1016/0960-894X(95)00225-I | |||
| CHEMBL28797 | 100222 | None | 0 | Guinea pig | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 361 | 6 | 1 | 3 | 5.6 | CCCCC1CCc2ccc(OCc3ccc4ccccc4n3)cc2C1O | 10.1016/0960-894X(95)00225-I | |||
| 9906952 | 210457 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| CHEMBL97287 | 210457 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 361 | 8 | 1 | 6 | 3.3 | c1ccc2nc(COc3ccc(OCCCc4nnn[nH]4)cc3)ccc2c1 | 10.1021/jm00166a016 | |||
| 44272233 | 99032 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL279849 | 99032 | None | 0 | Guinea pig | Binding | pKi | = | 8.2 | 8.2 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| 10202522 | 66147 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc(Cc3nnn[nH]3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18405 | 66147 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(OCc2ccc(Cc3nnn[nH]3)cc2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 44352148 | 18818 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL127842 | 18818 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 449 | 8 | 1 | 4 | 6.4 | O=C(O)c1ccc(COCc2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 44352151 | 18899 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | |||
| CHEMBL128364 | 18899 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 454 | 10 | 2 | 4 | 5.4 | O=C(O)CCCc1ccc(NC(=O)Cc2ccc(OCc3ccc4ccccc4n3)cc2)cc1 | 10.1021/jm990387k | |||
| 10348846 | 96582 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL26284 | 96582 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 615 | 10 | 2 | 6 | 5.5 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCC(C)C(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 44272084 | 66136 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18396 | 66136 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 439 | 8 | 1 | 7 | 4.6 | COc1cc(OCc2ccc(OCc3ccc4ccccc4n3)cc2)cc(-c2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| 10371399 | 95800 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 601 | 10 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCCC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| CHEMBL25841 | 95800 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 601 | 10 | 2 | 6 | 5.3 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCCC(F)(F)F)cc12 | 10.1021/jm00035a008 | |||
| 10348586 | 99705 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 601 | 10 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | |||
| CHEMBL284322 | 99705 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 601 | 10 | 2 | 6 | 5.4 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cn1ccc2ccc(C(=O)NCC(C)CC(F)(F)F)cc21 | 10.1021/jm00035a008 | |||
| 23224651 | 18919 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| CHEMBL128477 | 18919 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 486 | 7 | 2 | 6 | 5.1 | O=C(NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1 | 10.1021/jm990387k | |||
| 44353320 | 165126 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 561 | 11 | 2 | 6 | 5.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | |||
| CHEMBL422616 | 165126 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 561 | 11 | 2 | 6 | 5.2 | CCCc1cn(Cc2ccc(C(=O)NS(=O)(=O)c3ccccc3)cc2OC)c2cc(C(=O)NCC(C)C)ccc12 | 10.1021/jm00055a011 | |||
| 10100380 | 21037 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 617 | 14 | 2 | 6 | 6.5 | CCCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| CHEMBL131173 | 21037 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 617 | 14 | 2 | 6 | 6.5 | CCCCCCC(C)CNC(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| 44352424 | 21026 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL131166 | 21026 | None | 0 | Guinea pig | Binding | pKi | = | 7.2 | 7.2 | - | 1 | ChEMBL | 490 | 8 | 2 | 4 | 6.1 | CC(C(=O)NCc1ccc(C(=O)O)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 44292283 | 177374 | None | 0 | Guinea pig | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 347 | 4 | 1 | 5 | 3.6 | O=C(O)c1cc(=O)c2ccc(OCc3ccc4ccccc4n3)cc2o1 | 10.1021/jm00109a025 | |||
| CHEMBL46362 | 177374 | None | 0 | Guinea pig | Binding | pKi | = | 5.2 | 5.2 | - | 1 | ChEMBL | 347 | 4 | 1 | 5 | 3.6 | O=C(O)c1cc(=O)c2ccc(OCc3ccc4ccccc4n3)cc2o1 | 10.1021/jm00109a025 | |||
| 44278454 | 99938 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | -2 | 2 | ChEMBL | 468 | 6 | 0 | 5 | 7.0 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccccc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | |||
| CHEMBL28595 | 99938 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | -2 | 2 | ChEMBL | 468 | 6 | 0 | 5 | 7.0 | Cc1nc2cnccc2n1-c1ccc(OCc2cccc(/C=C/c3ccc4ccccc4n3)c2)cc1 | 10.1016/0960-894X(95)00227-K | |||
| 9820984 | 66732 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 375 | 9 | 1 | 6 | 3.7 | c1cc(OCCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL18558 | 66732 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 375 | 9 | 1 | 6 | 3.7 | c1cc(OCCCCc2nnn[nH]2)cc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a016 | |||
| 44352316 | 22261 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 502 | 9 | 2 | 4 | 6.2 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc(-c5ccccc5)cn4)cc3c2)cc1 | 10.1021/jm990387k | |||
| CHEMBL132341 | 22261 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 502 | 9 | 2 | 4 | 6.2 | O=C(O)c1ccc(CCNC(=O)c2ccc3ccc(OCc4ccc(-c5ccccc5)cn4)cc3c2)cc1 | 10.1021/jm990387k | |||
| 10031428 | 20681 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 595 | 10 | 2 | 6 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCc3ccccc3)cc12 | 10.1021/jm00055a011 | |||
| CHEMBL130873 | 20681 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 595 | 10 | 2 | 6 | 5.2 | COc1cc(C(=O)NS(=O)(=O)c2ccccc2C)ccc1Cc1cn(C)c2ccc(C(=O)NCCc3ccccc3)cc12 | 10.1021/jm00055a011 | |||
| 10371435 | 116990 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 603 | 13 | 1 | 6 | 6.2 | CCCCN(CCCC)C(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| CHEMBL338497 | 116990 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 603 | 13 | 1 | 6 | 6.2 | CCCCN(CCCC)C(=O)c1ccc2c(c1)c(Cc1ccc(C(=O)NS(=O)(=O)c3ccccc3C)cc1OC)cn2C | 10.1021/jm00055a011 | |||
| 9932067 | 66815 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18597 | 66815 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(Cc2nnn[nH]2)c1 | 10.1021/jm00166a017 | |||
| 9827188 | 67488 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 497 | 10 | 1 | 9 | 4.3 | COC(=O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18919 | 67488 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 497 | 10 | 1 | 9 | 4.3 | COC(=O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)c(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| 10114090 | 67541 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18956 | 67541 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 439 | 9 | 1 | 7 | 4.5 | c1cc(COc2ccc(OCc3ccc4ccccc4n3)cc2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a017 | |||
| 44352103 | 116754 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1021/jm990387k | |||
| CHEMBL337195 | 116754 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 526 | 9 | 2 | 5 | 5.6 | CC(NS(=O)(=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)c1ccccc1CC(=O)O | 10.1021/jm990387k | |||
| 10222948 | 66103 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 405 | 6 | 1 | 5 | 5.2 | C(=C/c1cccc(-c2nn[nH]n2)c1)\c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| CHEMBL18381 | 66103 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 405 | 6 | 1 | 5 | 5.2 | C(=C/c1cccc(-c2nn[nH]n2)c1)\c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1021/jm00166a017 | |||
| 15015282 | 67293 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc2nc(COc3ccc(OCc4ccc(Cc5nnn[nH]5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | |||
| CHEMBL18816 | 67293 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 423 | 8 | 1 | 6 | 4.5 | c1ccc2nc(COc3ccc(OCc4ccc(Cc5nnn[nH]5)cc4)cc3)ccc2c1 | 10.1021/jm00166a017 | |||
| 14708751 | 187411 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 409 | 6 | 2 | 6 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | |||
| CHEMBL49298 | 187411 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 409 | 6 | 2 | 6 | 4.3 | COc1cc(C(=O)O)ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc21 | 10.1021/jm00168a037 | |||
| 14626842 | 102103 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 420 | 7 | 2 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| CHEMBL301928 | 102103 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 420 | 7 | 2 | 4 | 5.0 | COc1cc(C(=O)O)ccc1Cc1cn(C)c2ccc(NC(=O)CC3CCCC3)cc12 | 10.1021/jm00168a037 | |||
| 105007 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| CHEMBL267475 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| CHEMBL267976 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.1 | 6.1 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00108a001 | |||
| 5059 | 208819 | None | 32 | Guinea pig | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00226-J | |||
| CHEMBL8747 | 208819 | None | 32 | Guinea pig | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00226-J | |||
| 5059 | 208819 | None | 32 | Guinea pig | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00225-I | |||
| CHEMBL8747 | 208819 | None | 32 | Guinea pig | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 335 | 8 | 1 | 3 | 5.4 | CCCCCC(O)c1cccc(OCc2ccc3ccccc3n2)c1 | 10.1016/0960-894X(95)00225-I | |||
| 14650343 | 64128 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 333 | 6 | 1 | 6 | 2.9 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a016 | |||
| CHEMBL18081 | 64128 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 333 | 6 | 1 | 6 | 2.9 | c1cc(OCc2ccc3ccccc3n2)cc(OCc2nn[nH]n2)c1 | 10.1021/jm00166a016 | |||
| 44352397 | 21203 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1021/jm990387k | |||
| CHEMBL131287 | 21203 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 504 | 7 | 2 | 8 | 4.0 | O=C(NCc1ccc(OCc2ccc3ccccc3n2)cc1)c1cccc2c(=O)cc(-c3nn[nH]n3)oc12 | 10.1021/jm990387k | |||
| 44286706 | 14622 | None | 0 | Guinea pig | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | |||
| CHEMBL1205015 | 14622 | None | 0 | Guinea pig | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | |||
| CHEMBL41301 | 14622 | None | 0 | Guinea pig | Binding | pKi | = | 5.1 | 5.1 | - | 1 | ChEMBL | 460 | 13 | 3 | 6 | 5.3 | CCCc1c(OCCCSc2ccc(C(O)[C@@H](C)CC(=O)O)cc2)ccc(C(C)=O)c1O | 10.1021/jm00159a003 | |||
| 44352159 | 19375 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | |||
| CHEMBL129142 | 19375 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 478 | 10 | 2 | 6 | 4.7 | O=C(Cc1ccc(OCc2ccc3ccccc3n2)cc1)Nc1ccc(CCCc2nnn[nH]2)cc1 | 10.1021/jm990387k | |||
| 448537 | 160344 | None | 54 | Human | Binding | pKi | = | 5.1 | 5.1 | -41 | 25 | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | |||
| CHEMBL411 | 160344 | None | 54 | Human | Binding | pKi | = | 5.1 | 5.1 | -41 | 25 | ChEMBL | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | nan | |||
| 44352186 | 22073 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1021/jm990387k | |||
| CHEMBL132167 | 22073 | None | 0 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | ChEMBL | 478 | 7 | 2 | 5 | 6.4 | O=C(Nc1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1)OCc1ccc(C(=O)O)cc1 | 10.1021/jm990387k | |||
| 44352154 | 165121 | None | 0 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| CHEMBL422609 | 165121 | None | 0 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | - | 1 | ChEMBL | 514 | 8 | 2 | 6 | 5.6 | CC(C(=O)NCc1ccc(-c2nn[nH]n2)cc1)c1ccc2cc(OCc3ccc4ccccc4n3)ccc2c1 | 10.1021/jm990387k | |||
| 10156907 | 67895 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm00166a017 | |||
| CHEMBL19102 | 67895 | None | 0 | Guinea pig | Binding | pKi | = | 7.1 | 7.1 | - | 1 | ChEMBL | 385 | 7 | 1 | 4 | 5.1 | O=C(O)c1ccc(COc2cccc(OCc3ccc4ccccc4n3)c2)cc1 | 10.1021/jm00166a017 | |||
| 105007 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | |||
| CHEMBL267475 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | |||
| CHEMBL267976 | 97153 | None | 25 | Guinea pig | Binding | pKi | = | 6.0 | 6.0 | - | 1 | ChEMBL | 498 | 12 | 3 | 8 | 4.1 | CCCc1c(OCC(O)COc2ccc3c(=O)cc(C(=O)O)oc3c2CCC)ccc(C(C)=O)c1O | 10.1021/jm00166a016 | |||
| 10346 | 2559 | None | 36 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | |||
| 5281888 | 2559 | None | 36 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | |||
| CHEMBL15177 | 2559 | None | 36 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 1 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCSC(c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 10391245 | |||
| 6193 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | |||
| 6509849 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | |||
| CHEMBL280481 | 3984 | None | 31 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | Guide to Pharmacology | 514 | 11 | 1 | 5 | 6.5 | OC(=O)CCS[C@H](c1cccc(c1)/C=C/c1ccc2c(n1)cc(cc2)Cl)SCCC(=O)N(C)C | 1666333 | |||
| 3353 | 2370 | None | 0 | Human | Binding | pKd | = | 9.2 | 9.2 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 3353 | 2370 | None | 0 | Human | Binding | pKd | = | 9.2 | 9.2 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | |||
| 3412 | 2370 | None | 0 | Human | Binding | pKd | = | 9.2 | 9.2 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 3412 | 2370 | None | 0 | Human | Binding | pKd | = | 9.2 | 9.2 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | |||
| 6435286 | 2370 | None | 0 | Human | Binding | pKd | = | 9.2 | 9.2 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| 6435286 | 2370 | None | 0 | Human | Binding | pKd | = | 9.2 | 9.2 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Binding | pKd | = | 9.2 | 9.2 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 10391245 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Binding | pKd | = | 9.2 | 9.2 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 16306225 | |||
| 3353 | 2370 | None | 0 | Human | Binding | pKd | = | 9.3 | 9.3 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | |||
| 3412 | 2370 | None | 0 | Human | Binding | pKd | = | 9.3 | 9.3 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | |||
| 6435286 | 2370 | None | 0 | Human | Binding | pKd | = | 9.3 | 9.3 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Binding | pKd | = | 9.3 | 9.3 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 14518564 | |||
| 3353 | 2370 | None | 0 | Human | Binding | pKd | = | 9.4 | 9.4 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | |||
| 3412 | 2370 | None | 0 | Human | Binding | pKd | = | 9.4 | 9.4 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | |||
| 6435286 | 2370 | None | 0 | Human | Binding | pKd | = | 9.4 | 9.4 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Binding | pKd | = | 9.4 | 9.4 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | None | |||
| 3353 | 2370 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | |||
| 3353 | 2370 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | |||
| 3412 | 2370 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | |||
| 3412 | 2370 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | |||
| 6435286 | 2370 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | |||
| 6435286 | 2370 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9504401 | |||
| CHEMBL1521056 | 2370 | None | 0 | Human | Binding | pKd | = | 9.6 | 9.6 | 21 | 2 | Guide to Pharmacology | 496 | 20 | 5 | 6 | 3.4 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N | 9547367 | |||
| 115219 | 1978 | None | 12 | Human | Binding | pKd | = | 10.6 | 10.6 | 489 | 3 | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | |||
| 3358 | 1978 | None | 12 | Human | Binding | pKd | = | 10.6 | 10.6 | 489 | 3 | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | |||
| 3414 | 1978 | None | 12 | Human | Binding | pKd | = | 10.6 | 10.6 | 489 | 3 | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | |||
| CHEMBL22033 | 1978 | None | 12 | Human | Binding | pKd | = | 10.6 | 10.6 | 489 | 3 | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 1329767 | |||
| 2855 | 4132 | 3H-LTD4 | 63 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 6 | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 3322 | 4132 | 3H-LTD4 | 63 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 6 | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 5717 | 4132 | 3H-LTD4 | 63 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 6 | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 5717.0 | 4132 | 3H-LTD4 | 63 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 6 | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| CHEMBL603 | 4132 | 3H-LTD4 | 63 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 6 | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| DB00549 | 4132 | 3H-LTD4 | 63 | Human | Binding | pKi | = | 9.6 | 9.6 | 1 | 6 | PDSP KiDatabase | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| None | 218708 | 3H-LTD4 | 0 | Human | Binding | pKi | = | 8.0 | 8.0 | 95 | 2 | PDSP KiDatabase | 514 | 11 | 1 | 5 | 6.5 | CN(C)C(=O)CCSC(C1=CC=CC(=C1)C=CC2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)O | None | |||
| None | 218695 | 3H-LTD4 | 0 | Human | Binding | pKi | = | 8.6 | 8.6 | 2187 | 4 | PDSP KiDatabase | 473 | 7 | 2 | 3 | 7.9 | CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)S)O | None | |||
| 2812 | 4781 | None | 63 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 1 | 34 | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | |||
| 2812 | 4781 | None | 63 | Human | Binding | pKi | = | 8.3 | 8.3 | -58 | 34 | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | |||
| CHEMBL104 | 4781 | None | 63 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 1 | 34 | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | |||
| CHEMBL104 | 4781 | None | 63 | Human | Binding | pKi | = | 8.3 | 8.3 | -58 | 34 | Drug Central | 344 | 4 | 0 | 2 | 5.4 | Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 | None | |||
| 57340263 | 218707 | 3H-LTD4 | 0 | Human | Binding | pKi | = | 6.4 | 6.4 | -1 | 2 | PDSP KiDatabase | 472 | 17 | 3 | 4 | 6.7 | CCCCC/C=C\C/C=C/C=C/C=C/[C@H]([C@H](CCCC(=O)O)O)SC1=CC=C(C=C1)C(=O)O | None | |||
| 448537 | 160344 | None | 54 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 15 | 25 | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | |||
| 448537 | 160344 | None | 54 | Human | Binding | pKi | = | 8.3 | 8.3 | -41 | 25 | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | |||
| CHEMBL411 | 160344 | None | 54 | Guinea pig | Binding | pKi | = | 8.3 | 8.3 | 15 | 25 | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | |||
| CHEMBL411 | 160344 | None | 54 | Human | Binding | pKi | = | 8.3 | 8.3 | -41 | 25 | Drug Central | 268 | 4 | 2 | 2 | 4.8 | CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 | None | |||
| 6436135 | 99626 | None | 31 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | Drug Central | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | None | |||
| CHEMBL283754 | 99626 | None | 31 | Guinea pig | Binding | pKi | = | 8.1 | 8.1 | - | 1 | Drug Central | 412 | 9 | 2 | 4 | 5.8 | CCC(CC)(CC(=O)Nc1cccc(/C=C/c2nc(C3CCC3)cs2)c1)C(=O)O | None | |||
| 2237 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 4 | 3 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| 3634 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 4 | 3 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| 4887 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 4 | 3 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| 4887.0 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 4 | 3 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| CHEMBL21333 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 4 | 3 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| DB01411 | 3162 | None | 53 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 4 | 3 | Drug Central | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | None | |||
| 1836 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| 3340 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| 5281040 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| 5281040.0 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| CHEMBL787 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| DB00471 | 2592 | None | 44 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | 1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| 1836 | 2592 | None | 44 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| 3340 | 2592 | None | 44 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| 5281040 | 2592 | None | 44 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| 5281040.0 | 2592 | None | 44 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| CHEMBL787 | 2592 | None | 44 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| DB00471 | 2592 | None | 44 | Human | Binding | pKi | = | 8.0 | 8.0 | -1 | 15 | Drug Central | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | None | |||
| 2855 | 4132 | None | 63 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 3322 | 4132 | None | 63 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 5717 | 4132 | None | 63 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 5717.0 | 4132 | None | 63 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| CHEMBL603 | 4132 | None | 63 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| DB00549 | 4132 | None | 63 | Human | Binding | pKi | = | 8.0 | 8.0 | 1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 2855 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | -1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 3322 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | -1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 5717 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | -1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 5717.0 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | -1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| CHEMBL603 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | -1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| DB00549 | 4132 | None | 63 | Guinea pig | Binding | pKi | = | 8.0 | 8.0 | -1 | 6 | Drug Central | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | None | |||
| 3352 | 2371 | None | 24 | Human | Binding | pKi | = | 7.4 | 7.4 | -15 | 3 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | |||
| 5280879 | 2371 | None | 24 | Human | Binding | pKi | = | 7.4 | 7.4 | -15 | 3 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | |||
| 5863 | 2371 | None | 24 | Human | Binding | pKi | = | 7.4 | 7.4 | -15 | 3 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | |||
| CHEMBL509456 | 2371 | None | 24 | Human | Binding | pKi | = | 7.4 | 7.4 | -15 | 3 | Guide to Pharmacology | 439 | 18 | 4 | 5 | 4.3 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)O)N | 9547367 | |||
| 3354 | 2369 | None | 23 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | |||
| 5280493 | 2369 | None | 23 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | |||
| CHEMBL451509 | 2369 | None | 23 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | |||
| DB08855 | 2369 | None | 23 | Human | Binding | pKi | = | 7.6 | 7.6 | - | 1 | Guide to Pharmacology | 625 | 25 | 7 | 8 | 2.8 | CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC[C@@H](C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N | 9547367 | |||
| 5861 | 2065 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | |||
| 6913104 | 2065 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | |||
| CHEMBL1206833 | 2065 | None | 0 | Human | Binding | pKi | = | 7.8 | 7.8 | - | 1 | Guide to Pharmacology | 710 | 16 | 3 | 8 | 8.9 | CCCc1c(OCCCC/C=C\C=C\[C@@H]([C@@H](c2cccc(c2)C(F)(F)F)O)Sc2ccc3c(c2)oc(cc3=O)C(=O)O)ccc(c1O)C(=O)C | 9504401 | |||
| 3327 | 3705 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | |||
| 6436123 | 3705 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | |||
| CHEMBL278570 | 3705 | None | 0 | Human | Binding | pKi | = | 8.3 | 8.3 | - | 1 | Guide to Pharmacology | 472 | 17 | 3 | 6 | 5.7 | CCCCCCCCC/C=C\C=C\[C@H]([C@H](c1cccc(c1)c1nnn[nH]1)O)SCCC(=O)O | None | |||
| 128355 | 3669 | None | 19 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | |||
| 3329 | 3669 | None | 19 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | |||
| CHEMBL18132 | 3669 | None | 19 | Human | Binding | pKi | = | 8.7 | 8.7 | - | 1 | Guide to Pharmacology | 370 | 6 | 2 | 4 | 5.3 | OC(=O)c1ccccc1Nc1cccc(c1)OCc1ccc2c(n1)cccc2 | None | |||
| 115219 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.7 | 9.7 | -489 | 3 | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | |||
| 3358 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.7 | 9.7 | -489 | 3 | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | |||
| 3414 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.7 | 9.7 | -489 | 3 | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | |||
| CHEMBL22033 | 1978 | None | 12 | Guinea pig | Binding | pKi | = | 9.7 | 9.7 | -489 | 3 | Guide to Pharmacology | 548 | 8 | 2 | 8 | 4.7 | COc1cc(ccc1Cn1ncc2c1cc(cc2)NC(=O)OC1CCCC1)C(=O)NS(=O)(=O)c1ccccc1 | 2170649 | |||
| 3334 | 3147 | None | 8 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | |||
| 60842 | 3147 | None | 8 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | |||
| CHEMBL22776 | 3147 | None | 8 | Human | Binding | pKi | = | 7.1 | 7.1 | -5 | 2 | Guide to Pharmacology | 458 | 16 | 3 | 4 | 5.5 | OC(=O)CCS[C@H](c1ccccc1CCCCCCCCc1ccccc1)[C@H](C(=O)O)O | 9547367 | |||
| 2237 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | |||
| 2237 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | |||
| 3634 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | |||
| 3634 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | |||
| 4887 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | |||
| 4887 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | |||
| 4887.0 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | |||
| 4887.0 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | |||
| CHEMBL21333 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | |||
| DB01411 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 11996896 | |||
| DB01411 | 3162 | None | 53 | Human | Binding | pKi | = | 8.0 | 8.0 | -4 | 3 | Guide to Pharmacology | 481 | 9 | 2 | 7 | 4.6 | O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1 | 9504401 | |||
| 1836 | 2592 | None | 44 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 15 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | |||
| 3340 | 2592 | None | 44 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 15 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | |||
| 5281040 | 2592 | None | 44 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 15 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | |||
| 5281040.0 | 2592 | None | 44 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 15 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | |||
| CHEMBL787 | 2592 | None | 44 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 15 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | |||
| DB00471 | 2592 | None | 44 | Human | Binding | pKi | = | 8.6 | 8.6 | -1 | 15 | Guide to Pharmacology | 585 | 12 | 2 | 4 | 8.9 | OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 | 11996896 | |||
| 2855 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | |||
| 2855 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | |||
| 3322 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | |||
| 3322 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | |||
| 5717 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | |||
| 5717 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | |||
| 5717.0 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | |||
| 5717.0 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | |||
| CHEMBL603 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | |||
| DB00549 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 11996896 | |||
| DB00549 | 4132 | None | 63 | Human | Binding | pKi | = | 8.9 | 8.9 | 1 | 6 | Guide to Pharmacology | 575 | 8 | 2 | 7 | 5.7 | COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C | 9504401 | |||