Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 77846754 | 182648 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | - | 1 | ChEMBL | 435 | 5 | 1 | 3 | 6.3 | Cc1cc(OC2CCC3(CCCC3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4787458 | 182648 | None | 0 | Human | Functional | pEC50 | = | 10.5 | 10.5 | - | 1 | ChEMBL | 435 | 5 | 1 | 3 | 6.3 | Cc1cc(OC2CCC3(CCCC3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 77846502 | 180746 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 423 | 6 | 2 | 3 | 6.1 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4754965 | 180746 | None | 0 | Human | Functional | pEC50 | = | 10.2 | 10.2 | - | 1 | ChEMBL | 423 | 6 | 2 | 3 | 6.1 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 12573 | 995 | None | 2 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| 77846592 | 995 | None | 2 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4748198 | 995 | None | 2 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| 77847762 | 183529 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 397 | 7 | 2 | 3 | 5.7 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4798593 | 183529 | None | 0 | Human | Functional | pEC50 | = | 10 | 10.0 | - | 1 | ChEMBL | 397 | 7 | 2 | 3 | 5.7 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 77846503 | 182416 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 451 | 6 | 2 | 3 | 6.9 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4784199 | 182416 | None | 0 | Human | Functional | pEC50 | = | 9.6 | 9.6 | - | 1 | ChEMBL | 451 | 6 | 2 | 3 | 6.9 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | |||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | |||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm050242f | |||
| 25192001 | 8061 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -2 | 4 | ChEMBL | 413 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | |||
| CHEMBL1091103 | 8061 | None | 0 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -2 | 4 | ChEMBL | 413 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | |||
| 11502996 | 158819 | None | 36 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -11 | 3 | ChEMBL | 435 | 9 | 1 | 4 | 5.0 | CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 | 10.1021/acs.jmedchem.7b00785 | |||
| CHEMBL4093489 | 158819 | None | 36 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -11 | 3 | ChEMBL | 435 | 9 | 1 | 4 | 5.0 | CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 | 10.1021/acs.jmedchem.7b00785 | |||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/ml100301k | |||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/ml100301k | |||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.5 | 9.5 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/ml100301k | |||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | |||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | |||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2010.02.006 | |||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.0c00631 | |||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.0c00631 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.4 | 9.4 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acsmedchemlett.5b00448 | |||
| 11222939 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| 44438254 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| CHEMBL190006 | 67596 | None | 8 | Human | Functional | pEC50 | = | 9.3 | 9.3 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| 46881623 | 6765 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 5 | 3 | ChEMBL | 477 | 9 | 2 | 6 | 4.1 | Cc1cc(CN2CC(C(=O)O)C2)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| CHEMBL1083828 | 6765 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | 5 | 3 | ChEMBL | 477 | 9 | 2 | 6 | 4.1 | Cc1cc(CN2CC(C(=O)O)C2)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| 59384310 | 104446 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 3 | ChEMBL | 511 | 13 | 3 | 7 | 5.2 | CCCCCCCCOc1ccc(-c2nnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F | 10.1021/ml400194r | |||
| CHEMBL3102904 | 104446 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -2 | 3 | ChEMBL | 511 | 13 | 3 | 7 | 5.2 | CCCCCCCCOc1ccc(-c2nnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F | 10.1021/ml400194r | |||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | |||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | |||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.8b01695 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.0c01109 | |||
| 44412994 | 78351 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -7 | 3 | ChEMBL | 499 | 7 | 1 | 6 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C(F)(F)F)C(F)(F)F)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL210942 | 78351 | None | 0 | Human | Functional | pEC50 | = | 9.2 | 9.2 | -7 | 3 | ChEMBL | 499 | 7 | 1 | 6 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C(F)(F)F)C(F)(F)F)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 77846505 | 180122 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 437 | 6 | 2 | 3 | 6.5 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CCC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4747262 | 180122 | None | 0 | Human | Functional | pEC50 | = | 9.1 | 9.1 | - | 1 | ChEMBL | 437 | 6 | 2 | 3 | 6.5 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNC2CCC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | |||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | |||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2006.10.014 | |||
| 11568622 | 158293 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -1 | 2 | ChEMBL | 450 | 9 | 1 | 5 | 4.7 | CCCc1ccc(COc2ccc3c(c2C)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)n1 | 10.1021/acs.jmedchem.7b00785 | |||
| CHEMBL4087932 | 158293 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -1 | 2 | ChEMBL | 450 | 9 | 1 | 5 | 4.7 | CCCc1ccc(COc2ccc3c(c2C)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)n1 | 10.1021/acs.jmedchem.7b00785 | |||
| 77847765 | 183505 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 423 | 5 | 1 | 3 | 6.0 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CN2CCC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4798181 | 183505 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 423 | 5 | 1 | 3 | 6.0 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CN2CCC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 44599207 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | ChEMBL | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 10.1016/j.bmcl.2013.09.058 | |||
| 44599207.0 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | ChEMBL | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 10.1016/j.bmcl.2013.09.058 | |||
| 5326 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | ChEMBL | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 10.1016/j.bmcl.2013.09.058 | |||
| 9289 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | ChEMBL | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 10.1016/j.bmcl.2013.09.058 | |||
| CHEMBL2336071 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | ChEMBL | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 10.1016/j.bmcl.2013.09.058 | |||
| DB12371 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | ChEMBL | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 10.1016/j.bmcl.2013.09.058 | |||
| 11619303 | 159042 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 2 | ChEMBL | 449 | 9 | 1 | 4 | 5.3 | CCCc1ccc(COc2ccc3c(c2C)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 | 10.1021/acs.jmedchem.7b00785 | |||
| CHEMBL4095920 | 159042 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 2 | ChEMBL | 449 | 9 | 1 | 4 | 5.3 | CCCc1ccc(COc2ccc3c(c2C)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 | 10.1021/acs.jmedchem.7b00785 | |||
| 77846753 | 180955 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 449 | 5 | 1 | 3 | 6.7 | Cc1cc(OC2CCC3(CCCCC3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4757160 | 180955 | None | 0 | Human | Functional | pEC50 | = | 9.0 | 9.0 | - | 1 | ChEMBL | 449 | 5 | 1 | 3 | 6.7 | Cc1cc(OC2CCC3(CCCCC3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 90324880 | 180463 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 343 | 11 | 2 | 3 | 4.7 | CCCCCCOc1cc(C)c2ccccc2c1CNCCC(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4751484 | 180463 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 343 | 11 | 2 | 3 | 4.7 | CCCCCCOc1cc(C)c2ccccc2c1CNCCC(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| 77847763 | 181914 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 411 | 8 | 2 | 3 | 6.1 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCCCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4778095 | 181914 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | - | 1 | ChEMBL | 411 | 8 | 2 | 3 | 6.1 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCCCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 46884020 | 8442 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 4 | ChEMBL | 397 | 11 | 3 | 3 | 4.5 | CCCCCCCCc1ccc2c(c1)CC[C@H]([C@@](C)(N)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | |||
| CHEMBL1093686 | 8442 | None | 0 | Human | Functional | pEC50 | = | 8.8 | 8.8 | -8 | 4 | ChEMBL | 397 | 11 | 3 | 3 | 4.5 | CCCCCCCCc1ccc2c(c1)CC[C@H]([C@@](C)(N)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | |||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/ml400194r | |||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/ml400194r | |||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/ml400194r | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/ml400194r | |||
| 10904818 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 4 | ChEMBL | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 10.1016/j.bmcl.2005.09.038 | |||
| 2937 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 4 | ChEMBL | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 10.1016/j.bmcl.2005.09.038 | |||
| CHEMBL382739 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | 1 | 4 | ChEMBL | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 10.1016/j.bmcl.2005.09.038 | |||
| 44406004 | 72740 | None | 10 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -11 | 4 | ChEMBL | 337 | 14 | 4 | 4 | 2.9 | CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O | 10.1016/j.bmcl.2005.09.038 | |||
| CHEMBL199791 | 72740 | None | 10 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -11 | 4 | ChEMBL | 337 | 14 | 4 | 4 | 2.9 | CCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(=O)(O)O | 10.1016/j.bmcl.2005.09.038 | |||
| 11678855 | 134512 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 607 | 21 | 4 | 10 | 5.9 | C[C@@](N)(CCc1ccc(OCCCCCCCCCCCNc2ccc([N+](=O)[O-])c3nonc23)cc1)COP(=O)(O)O | 10.1016/j.bmcl.2005.09.038 | |||
| CHEMBL371758 | 134512 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -1 | 3 | ChEMBL | 607 | 21 | 4 | 10 | 5.9 | C[C@@](N)(CCc1ccc(OCCCCCCCCCCCNc2ccc([N+](=O)[O-])c3nonc23)cc1)COP(=O)(O)O | 10.1016/j.bmcl.2005.09.038 | |||
| 16215109 | 147596 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 44438256 | 147596 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| CHEMBL393055 | 147596 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 16215109 | 147596 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 | 10.1016/j.bmcl.2011.09.049 | |||
| 44438256 | 147596 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL393055 | 147596 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](COP(=O)(O)O)N[C@@H]2CO)cc1 | 10.1016/j.bmcl.2011.09.049 | |||
| 78321974 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -22 | 3 | ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acsmedchemlett.5b00448 | |||
| CHEMBL3806205 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -22 | 3 | ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acsmedchemlett.5b00448 | |||
| 78321974 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -22 | 3 | ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.8b01695 | |||
| CHEMBL3806205 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -22 | 3 | ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.8b01695 | |||
| 78321974 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -22 | 3 | ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | |||
| CHEMBL3806205 | 140401 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -22 | 3 | ChEMBL | 409 | 9 | 3 | 3 | 4.8 | CCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | |||
| 66655386 | 167626 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc32)C1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4218296 | 167626 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc32)C1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300113 | 167626 | None | 0 | Human | Functional | pEC50 | = | 7 | 7.0 | - | 1 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCCC2(COc3cc(OCc4c(Cl)cccc4Cl)ccc32)C1 | 10.1016/j.bmcl.2017.12.018 | |||
| 66655175 | 167674 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 367 | 6 | 1 | 4 | 3.5 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4213649 | 167674 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 367 | 6 | 1 | 4 | 3.5 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300641 | 167674 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | - | 1 | ChEMBL | 367 | 6 | 1 | 4 | 3.5 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 46881912 | 6768 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -2 | 4 | ChEMBL | 425 | 13 | 2 | 5 | 2.8 | CCCCCCCOc1ccc(CC[C@](C)(N)CCN2CC(=O)NS2(=O)=O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| CHEMBL1083841 | 6768 | None | 0 | Human | Functional | pEC50 | = | 6 | 6.0 | -2 | 4 | ChEMBL | 425 | 13 | 2 | 5 | 2.8 | CCCCCCCOc1ccc(CC[C@](C)(N)CCN2CC(=O)NS2(=O)=O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| 44412827 | 77770 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -89 | 3 | ChEMBL | 432 | 9 | 1 | 4 | 6.9 | Cc1cc(CCCCCC(=O)O)ccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL209008 | 77770 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -89 | 3 | ChEMBL | 432 | 9 | 1 | 4 | 6.9 | Cc1cc(CCCCCC(=O)O)ccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 44517795 | 68323 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -109 | 5 | ChEMBL | 472 | 6 | 1 | 7 | 3.9 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)CCN4C(=O)CCC(=O)O)no2)c1 | 10.1016/j.bmcl.2011.05.110 | |||
| CHEMBL1916399 | 68323 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -109 | 5 | ChEMBL | 472 | 6 | 1 | 7 | 3.9 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)CCN4C(=O)CCC(=O)O)no2)c1 | 10.1016/j.bmcl.2011.05.110 | |||
| 42630194 | 75804 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -7 | 5 | ChEMBL | 468 | 5 | 2 | 6 | 5.2 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 | 10.1016/j.bmcl.2012.04.129 | |||
| CHEMBL2048287 | 75804 | None | 0 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -7 | 5 | ChEMBL | 468 | 5 | 2 | 6 | 5.2 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 | 10.1016/j.bmcl.2012.04.129 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.5b00928 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.5b00928 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.5b00928 | |||
| 172442402 | 195509 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -6 | 3 | ChEMBL | 472 | 9 | 1 | 6 | 3.5 | CC(C)Oc1ccc(COc2ccc3c(c2)CCCN(S(=O)(=O)CCC(=O)O)C3)cc1C#N | 10.1021/acs.jmedchem.3c00498 | |||
| CHEMBL5405061 | 195509 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -6 | 3 | ChEMBL | 472 | 9 | 1 | 6 | 3.5 | CC(C)Oc1ccc(COc2ccc3c(c2)CCCN(S(=O)(=O)CCC(=O)O)C3)cc1C#N | 10.1021/acs.jmedchem.3c00498 | |||
| 25154344 | 6542 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -38 | 3 | ChEMBL | 515 | 11 | 3 | 7 | 3.3 | Cc1cc(S(=O)(=O)NCCC(=O)O)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| CHEMBL1082869 | 6542 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -38 | 3 | ChEMBL | 515 | 11 | 3 | 7 | 3.3 | Cc1cc(S(=O)(=O)NCCC(=O)O)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| 66655656 | 167659 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 431 | 5 | 1 | 3 | 5.4 | O=C(O)CCN1CCC2(CC1)COc1cc(/C=C/c3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4218826 | 167659 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 431 | 5 | 1 | 3 | 5.4 | O=C(O)CCN1CCC2(CC1)COc1cc(/C=C/c3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300415 | 167659 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 431 | 5 | 1 | 3 | 5.4 | O=C(O)CCN1CCC2(CC1)COc1cc(/C=C/c3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 66655211 | 167837 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 316 | 2 | ChEMBL | 451 | 6 | 1 | 4 | 5.5 | O=C(O)CCN1CCC2(CC1)COc1cc(SCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4205124 | 167837 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 316 | 2 | ChEMBL | 451 | 6 | 1 | 4 | 5.5 | O=C(O)CCN1CCC2(CC1)COc1cc(SCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4302786 | 167837 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | 316 | 2 | ChEMBL | 451 | 6 | 1 | 4 | 5.5 | O=C(O)CCN1CCC2(CC1)COc1cc(SCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 58344592 | 154656 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -100 | 4 | ChEMBL | 445 | 7 | 1 | 7 | 3.7 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCC(=O)N(C)C)no2)cc1C#N | nan | |||
| CHEMBL3921214 | 154656 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -100 | 4 | ChEMBL | 445 | 7 | 1 | 7 | 3.7 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCC(=O)N(C)C)no2)cc1C#N | nan | |||
| CHEMBL3991184 | 154656 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -100 | 4 | ChEMBL | 445 | 7 | 1 | 7 | 3.7 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCC(=O)N(C)C)no2)cc1C#N | nan | |||
| 11654374 | 78413 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -660 | 2 | ChEMBL | 406 | 7 | 1 | 5 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1ncc(-c2ccc(OC(C)C)c(C#N)c2)s1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL211046 | 78413 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -660 | 2 | ChEMBL | 406 | 7 | 1 | 5 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1ncc(-c2ccc(OC(C)C)c(C#N)c2)s1 | 10.1016/j.bmcl.2006.04.064 | |||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | |||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | |||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | |||
| 77846594 | 181608 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 409 | 6 | 1 | 3 | 5.8 | CC[C@H]1CC[C@@H](Oc2cc(C)c3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4764896 | 181608 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | - | 1 | ChEMBL | 409 | 6 | 1 | 3 | 5.8 | CC[C@H]1CC[C@@H](Oc2cc(C)c3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| 66655306 | 167720 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 469 | 6 | 1 | 4 | 5.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3C(F)(F)F)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4208787 | 167720 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 469 | 6 | 1 | 4 | 5.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3C(F)(F)F)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4301342 | 167720 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 469 | 6 | 1 | 4 | 5.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3C(F)(F)F)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 66655521 | 167827 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 401 | 6 | 1 | 4 | 4.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3ccccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4204779 | 167827 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 401 | 6 | 1 | 4 | 4.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3ccccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4302677 | 167827 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | - | 1 | ChEMBL | 401 | 6 | 1 | 4 | 4.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3ccccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 11689680 | 79671 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -102 | 3 | ChEMBL | 391 | 7 | 1 | 6 | 4.4 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL211505 | 79671 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -102 | 3 | ChEMBL | 391 | 7 | 1 | 6 | 4.4 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| 44439851 | 145735 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -37 | 3 | ChEMBL | 403 | 6 | 1 | 6 | 4.6 | Cc1cc([C@@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL391581 | 145735 | None | 0 | Human | Functional | pEC50 | = | 7.9 | 7.9 | -37 | 3 | ChEMBL | 403 | 6 | 1 | 6 | 4.6 | Cc1cc([C@@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 46224767 | 201754 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -18 | 4 | ChEMBL | 293 | 2 | 0 | 4 | 3.2 | Cc1nn(C(=O)/C=C/c2ccncc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| CHEMBL590383 | 201754 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -18 | 4 | ChEMBL | 293 | 2 | 0 | 4 | 3.2 | Cc1nn(C(=O)/C=C/c2ccncc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| 44412865 | 79934 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -616 | 2 | ChEMBL | 417 | 7 | 1 | 6 | 5.0 | Cc1cc(CCC(=O)O)ccc1-c1nnc(-c2cnc(OC(C)C)c(Cl)c2)s1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL212420 | 79934 | None | 0 | Human | Functional | pEC50 | = | 5.9 | 5.9 | -616 | 2 | ChEMBL | 417 | 7 | 1 | 6 | 5.0 | Cc1cc(CCC(=O)O)ccc1-c1nnc(-c2cnc(OC(C)C)c(Cl)c2)s1 | 10.1016/j.bmcl.2006.04.064 | |||
| 44438257 | 93879 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 44438258 | 93879 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| CHEMBL247698 | 93879 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | 2 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@H]2C[C@H](CO)N[C@@H]2COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 25110406 | 1296 | None | 44 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -81 | 4 | ChEMBL | 409 | 9 | 2 | 7 | 3.8 | OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC | nan | |||
| 2928 | 1296 | None | 44 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -81 | 4 | ChEMBL | 409 | 9 | 2 | 7 | 3.8 | OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC | nan | |||
| CHEMBL3922179 | 1296 | None | 44 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -81 | 4 | ChEMBL | 409 | 9 | 2 | 7 | 3.8 | OCCNC1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)OCC)OCC | nan | |||
| 11603726 | 76858 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -588 | 3 | ChEMBL | 400 | 7 | 1 | 5 | 5.2 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL206940 | 76858 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -588 | 3 | ChEMBL | 400 | 7 | 1 | 5 | 5.2 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 25182899 | 6125 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -11 | 3 | ChEMBL | 350 | 7 | 2 | 5 | 3.2 | CCCN(CC1CC1)c1cc(C(=O)Nc2ccc3[nH]ncc3c2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| CHEMBL1080865 | 6125 | None | 0 | Human | Functional | pEC50 | = | 6.9 | 6.9 | -11 | 3 | ChEMBL | 350 | 7 | 2 | 5 | 3.2 | CCCN(CC1CC1)c1cc(C(=O)Nc2ccc3[nH]ncc3c2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| 57390239 | 67930 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 1 | 4 | ChEMBL | 339 | 3 | 0 | 4 | 3.7 | C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910687 | 67930 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 1 | 4 | ChEMBL | 339 | 3 | 0 | 4 | 3.7 | C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 42630194 | 75804 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -7 | 5 | ChEMBL | 468 | 5 | 2 | 6 | 5.2 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 | 10.1016/j.bmcl.2012.04.129 | |||
| CHEMBL2048287 | 75804 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -7 | 5 | ChEMBL | 468 | 5 | 2 | 6 | 5.2 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4[nH]c5c(c4c3)CCC5CC(=O)O)no2)c1 | 10.1016/j.bmcl.2012.04.129 | |||
| 44412936 | 138853 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -213 | 3 | ChEMBL | 405 | 8 | 1 | 6 | 4.8 | CC[C@H](C)Oc1ccc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)cc1C#N | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL378054 | 138853 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -213 | 3 | ChEMBL | 405 | 8 | 1 | 6 | 4.8 | CC[C@H](C)Oc1ccc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)cc1C#N | 10.1016/j.bmcl.2006.04.084 | |||
| 58344526 | 150216 | None | 3 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -95 | 5 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCCO)no2)cc1C#N | nan | |||
| CHEMBL3951270 | 150216 | None | 3 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -95 | 5 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NCCO)no2)cc1C#N | nan | |||
| 58344520 | 146664 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -169 | 2 | ChEMBL | 445 | 7 | 1 | 7 | 3.7 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4NCC(=O)N(C)C)no2)cc1C#N | nan | |||
| CHEMBL3922998 | 146664 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -169 | 2 | ChEMBL | 445 | 7 | 1 | 7 | 3.7 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4NCC(=O)N(C)C)no2)cc1C#N | nan | |||
| 66655198 | 163755 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 79 | 3 | ChEMBL | 449 | 7 | 1 | 4 | 5.2 | O=C(O)CCCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4204437 | 163755 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 79 | 3 | ChEMBL | 449 | 7 | 1 | 4 | 5.2 | O=C(O)CCCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 66655680 | 167707 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 429 | 7 | 1 | 4 | 4.7 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4210234 | 167707 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 429 | 7 | 1 | 4 | 4.7 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4301008 | 167707 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | - | 1 | ChEMBL | 429 | 7 | 1 | 4 | 4.7 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| 145947403 | 167768 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 125 | 3 | ChEMBL | 443 | 8 | 1 | 4 | 5.1 | CCCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4205878 | 167768 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 125 | 3 | ChEMBL | 443 | 8 | 1 | 4 | 5.1 | CCCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4301965 | 167768 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 125 | 3 | ChEMBL | 443 | 8 | 1 | 4 | 5.1 | CCCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| 56601980 | 167786 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 19 | 2 | ChEMBL | 443 | 7 | 1 | 4 | 4.9 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CC(C)C(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4205225 | 167786 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 19 | 2 | ChEMBL | 443 | 7 | 1 | 4 | 4.9 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CC(C)C(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4302166 | 167786 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | 19 | 2 | ChEMBL | 443 | 7 | 1 | 4 | 4.9 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CC(C)C(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| 11603528 | 140145 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -154 | 2 | ChEMBL | 391 | 7 | 1 | 7 | 3.3 | Cc1cc(CCC(=O)O)ccc1-n1nnc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL380040 | 140145 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -154 | 2 | ChEMBL | 391 | 7 | 1 | 7 | 3.3 | Cc1cc(CCC(=O)O)ccc1-n1nnc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| 77846593 | 182615 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 457 | 6 | 1 | 3 | 6.6 | Cc1cc(O[C@H]2CC[C@@H](c3ccccc3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4787014 | 182615 | None | 0 | Human | Functional | pEC50 | = | 5.8 | 5.8 | - | 1 | ChEMBL | 457 | 6 | 1 | 3 | 6.6 | Cc1cc(O[C@H]2CC[C@@H](c3ccccc3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 66655846 | 167856 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 39 | 2 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4215002 | 167856 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 39 | 2 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4303021 | 167856 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | 39 | 2 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 49848557 | 1098 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -6 | 5 | ChEMBL | 461 | 7 | 1 | 8 | 4.0 | OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C | 10.1021/acs.jmedchem.5b01512 | |||
| 9492 | 1098 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -6 | 5 | ChEMBL | 461 | 7 | 1 | 8 | 4.0 | OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C | 10.1021/acs.jmedchem.5b01512 | |||
| CHEMBL3769933 | 1098 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -6 | 5 | ChEMBL | 461 | 7 | 1 | 8 | 4.0 | OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C | 10.1021/acs.jmedchem.5b01512 | |||
| 44125170 | 65976 | None | 5 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -16 | 2 | ChEMBL | 446 | 7 | 1 | 7 | 4.2 | Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(CCC(=O)O)C2 | 10.1021/jm200609t | |||
| CHEMBL1836169 | 65976 | None | 5 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -16 | 2 | ChEMBL | 446 | 7 | 1 | 7 | 4.2 | Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(CCC(=O)O)C2 | 10.1021/jm200609t | |||
| 77846674 | 181066 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 549 | 5 | 1 | 3 | 6.7 | CC(C)(C)[C@H]1CC[C@H](Oc2cc(I)c3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4758438 | 181066 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | - | 1 | ChEMBL | 549 | 5 | 1 | 3 | 6.7 | CC(C)(C)[C@H]1CC[C@H](Oc2cc(I)c3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| 11977938 | 70934 | None | 28 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -11 | 4 | ChEMBL | 461 | 8 | 1 | 7 | 5.3 | CCc1cc(CN2CC(C(=O)O)C2)sc1-c1noc(-c2ccc(Oc3ccccc3)cc2)n1 | 10.1016/j.ejmech.2012.02.022 | |||
| CHEMBL1951304 | 70934 | None | 28 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -11 | 4 | ChEMBL | 461 | 8 | 1 | 7 | 5.3 | CCc1cc(CN2CC(C(=O)O)C2)sc1-c1noc(-c2ccc(Oc3ccccc3)cc2)n1 | 10.1016/j.ejmech.2012.02.022 | |||
| 9969355 | 58458 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 3 | ChEMBL | 369 | 14 | 2 | 3 | 4.5 | O=C(O)CCNCCCc1ccc(OCCCCCc2ccccc2)cc1 | 10.1016/j.bmcl.2011.01.029 | |||
| CHEMBL1683041 | 58458 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -1 | 3 | ChEMBL | 369 | 14 | 2 | 3 | 4.5 | O=C(O)CCNCCCc1ccc(OCCCCCc2ccccc2)cc1 | 10.1016/j.bmcl.2011.01.029 | |||
| 52938055 | 147703 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -478 | 2 | ChEMBL | 482 | 9 | 1 | 8 | 3.6 | COCCS(=O)(=O)N[C@H]1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21 | nan | |||
| CHEMBL3931243 | 147703 | None | 0 | Human | Functional | pEC50 | = | 6.8 | 6.8 | -478 | 2 | ChEMBL | 482 | 9 | 1 | 8 | 3.6 | COCCS(=O)(=O)N[C@H]1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21 | nan | |||
| 11869937 | 201613 | None | 4 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -75 | 2 | ChEMBL | 292 | 2 | 0 | 3 | 3.8 | Cc1nn(C(=O)/C=C/c2ccccc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| CHEMBL589402 | 201613 | None | 4 | Human | Functional | pEC50 | = | 5.8 | 5.8 | -75 | 2 | ChEMBL | 292 | 2 | 0 | 3 | 3.8 | Cc1nn(C(=O)/C=C/c2ccccc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| 44422604 | 85482 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -9 | 5 | ChEMBL | 432 | 15 | 4 | 4 | 4.4 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CC(F)OP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL226612 | 85482 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -9 | 5 | ChEMBL | 432 | 15 | 4 | 4 | 4.4 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CC(F)OP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| 46881875 | 7332 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 4 | ChEMBL | 371 | 13 | 3 | 3 | 4.3 | CCCCCCCOc1ccc(CC[C@](C)(N)CCP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| CHEMBL1086170 | 7332 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 4 | ChEMBL | 371 | 13 | 3 | 3 | 4.3 | CCCCCCCOc1ccc(CC[C@](C)(N)CCP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| 66655362 | 163714 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 79 | 3 | ChEMBL | 423 | 8 | 1 | 4 | 4.6 | CCc1cccc(CC)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4203755 | 163714 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 79 | 3 | ChEMBL | 423 | 8 | 1 | 4 | 4.6 | CCc1cccc(CC)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| 66654900 | 167690 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 199 | 2 | ChEMBL | 485 | 7 | 1 | 5 | 5.0 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3OC(F)(F)F)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4217573 | 167690 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 199 | 2 | ChEMBL | 485 | 7 | 1 | 5 | 5.0 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3OC(F)(F)F)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300821 | 167690 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 199 | 2 | ChEMBL | 485 | 7 | 1 | 5 | 5.0 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3OC(F)(F)F)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 56599785 | 167760 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 12 | 2 | ChEMBL | 487 | 7 | 2 | 5 | 4.4 | O=P(O)(O)OCCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4205748 | 167760 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 12 | 2 | ChEMBL | 487 | 7 | 2 | 5 | 4.4 | O=P(O)(O)OCCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4301854 | 167760 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 12 | 2 | ChEMBL | 487 | 7 | 2 | 5 | 4.4 | O=P(O)(O)OCCN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 53492750 | 65987 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -6 | 2 | ChEMBL | 448 | 7 | 2 | 8 | 3.1 | Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(CO)CO)C2 | 10.1021/jm200609t | |||
| CHEMBL1836215 | 65987 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -6 | 2 | ChEMBL | 448 | 7 | 2 | 8 | 3.1 | Cc1c(-c2noc(-c3ccc(OC(C)C)c(C#N)c3)n2)ccc2c1CCN(C(CO)CO)C2 | 10.1021/jm200609t | |||
| 25182769 | 6267 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -7 | 3 | ChEMBL | 380 | 6 | 2 | 5 | 4.3 | Cc1cc(O)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| CHEMBL1081645 | 6267 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -7 | 3 | ChEMBL | 380 | 6 | 2 | 5 | 4.3 | Cc1cc(O)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| 57390243 | 67944 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -2 | 2 | ChEMBL | 383 | 6 | 0 | 5 | 3.7 | COCC/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910802 | 67944 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -2 | 2 | ChEMBL | 383 | 6 | 0 | 5 | 3.7 | COCC/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 11222939 | 67596 | None | 8 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.02.006 | |||
| 44438254 | 67596 | None | 8 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.02.006 | |||
| CHEMBL190006 | 67596 | None | 8 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.02.006 | |||
| 66655583 | 167675 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 7 | 2 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cccc(Cl)c3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4210576 | 167675 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 7 | 2 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cccc(Cl)c3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300642 | 167675 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 7 | 2 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cccc(Cl)c3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 66655587 | 167736 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 5 | 3 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cc(Cl)ccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4205714 | 167736 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 5 | 3 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cc(Cl)ccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4301563 | 167736 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | 5 | 3 | ChEMBL | 435 | 6 | 1 | 4 | 4.8 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cc(Cl)ccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 68082485 | 167618 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 3 | ChEMBL | 395 | 8 | 1 | 4 | 3.9 | O=C(O)CCN1CCC2(CC1)COc1cc(OCCCc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4207162 | 167618 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 3 | ChEMBL | 395 | 8 | 1 | 4 | 3.9 | O=C(O)CCN1CCC2(CC1)COc1cc(OCCCc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300006 | 167618 | None | 0 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -1 | 3 | ChEMBL | 395 | 8 | 1 | 4 | 3.9 | O=C(O)CCN1CCC2(CC1)COc1cc(OCCCc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 59384375 | 104445 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -4 | 3 | ChEMBL | 510 | 13 | 3 | 6 | 5.9 | CCCCCCCCOc1ccc(-c2cnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F | 10.1021/ml400194r | |||
| CHEMBL3102903 | 104445 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -4 | 3 | ChEMBL | 510 | 13 | 3 | 6 | 5.9 | CCCCCCCCOc1ccc(-c2cnc([C@@](C)(N)COP(=O)(O)O)s2)cc1C(F)(F)F | 10.1021/ml400194r | |||
| 46881847 | 7060 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(CC[C@](C)(N)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| CHEMBL1084929 | 7060 | None | 0 | Human | Functional | pEC50 | = | 8.7 | 8.7 | -2 | 4 | ChEMBL | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(CC[C@](C)(N)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| 77847681 | 183396 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 409 | 5 | 1 | 3 | 5.6 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CN2CC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4796939 | 183396 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | - | 1 | ChEMBL | 409 | 5 | 1 | 3 | 5.6 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CN2CC(C(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 66655236 | 167787 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 50 | 2 | ChEMBL | 445 | 7 | 1 | 4 | 5.4 | CCc1cccc(Cl)c1CSc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4210019 | 167787 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 50 | 2 | ChEMBL | 445 | 7 | 1 | 4 | 5.4 | CCc1cccc(Cl)c1CSc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4302167 | 167787 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 50 | 2 | ChEMBL | 445 | 7 | 1 | 4 | 5.4 | CCc1cccc(Cl)c1CSc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| 11222939 | 67596 | None | 8 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 44438254 | 67596 | None | 8 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| CHEMBL190006 | 67596 | None | 8 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -9 | 4 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(CC[C@@](N)(CO)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 58344778 | 154627 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -117 | 5 | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N | nan | |||
| CHEMBL3902160 | 154627 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -117 | 5 | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N | nan | |||
| CHEMBL3990889 | 154627 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -117 | 5 | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4N)no2)cc1C#N | nan | |||
| 44412661 | 139630 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -14 | 2 | ChEMBL | 406 | 7 | 1 | 5 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)s1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL379612 | 139630 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -14 | 2 | ChEMBL | 406 | 7 | 1 | 5 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1cnc(-c2ccc(OC(C)C)c(C#N)c2)s1 | 10.1016/j.bmcl.2006.04.064 | |||
| 46866185 | 7334 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -10 | 4 | ChEMBL | 321 | 12 | 2 | 3 | 4.2 | CCCCCCCOc1ccc(CC[C@](C)(N)CC(=O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| CHEMBL1086172 | 7334 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -10 | 4 | ChEMBL | 321 | 12 | 2 | 3 | 4.2 | CCCCCCCOc1ccc(CC[C@](C)(N)CC(=O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| 44138103 | 75810 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -131 | 4 | ChEMBL | 468 | 5 | 1 | 7 | 5.1 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)cc3n4CCC3CC(=O)O)no2)c1 | 10.1016/j.bmcl.2012.04.129 | |||
| CHEMBL2048293 | 75810 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -131 | 4 | ChEMBL | 468 | 5 | 1 | 7 | 5.1 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)cc3n4CCC3CC(=O)O)no2)c1 | 10.1016/j.bmcl.2012.04.129 | |||
| 11676168 | 70974 | None | 14 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -19 | 4 | ChEMBL | 422 | 11 | 3 | 5 | 3.3 | Cc1ccc(CCCC(=O)c2ccc(CC[C@@](C)(N)COP(=O)(O)O)n2C)cc1 | 10.1021/ml100301k | |||
| CHEMBL1951588 | 70974 | None | 14 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -19 | 4 | ChEMBL | 422 | 11 | 3 | 5 | 3.3 | Cc1ccc(CCCC(=O)c2ccc(CC[C@@](C)(N)COP(=O)(O)O)n2C)cc1 | 10.1021/ml100301k | |||
| 44438261 | 93913 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 44438262 | 93913 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| CHEMBL247901 | 93913 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | 1 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@@H]2C[C@@H](CO)N[C@H]2COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 11646599 | 77695 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -1047 | 3 | ChEMBL | 380 | 7 | 1 | 5 | 4.8 | Cc1cc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)ccc1OC(C)C | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL208898 | 77695 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -1047 | 3 | ChEMBL | 380 | 7 | 1 | 5 | 4.8 | Cc1cc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)ccc1OC(C)C | 10.1016/j.bmcl.2006.04.084 | |||
| 10311 | 1293 | None | 32 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -37 | 2 | ChEMBL | 405 | 5 | 0 | 5 | 3.9 | COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 49835928 | 1293 | None | 32 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -37 | 2 | ChEMBL | 405 | 5 | 0 | 5 | 3.9 | COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910803 | 1293 | None | 32 | Human | Functional | pEC50 | = | 5.7 | 5.7 | -37 | 2 | ChEMBL | 405 | 5 | 0 | 5 | 3.9 | COCCN=C1S/C(=C\c2cc(n(c2C)c2ccc(cc2F)F)C)/C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 57397321 | 67933 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 3 | ChEMBL | 403 | 5 | 0 | 4 | 4.7 | CC/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1CC | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910690 | 67933 | None | 0 | Human | Functional | pEC50 | = | 7.7 | 7.7 | -1 | 3 | ChEMBL | 403 | 5 | 0 | 4 | 4.7 | CC/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1CC | 10.1016/j.bmcl.2011.09.049 | |||
| 11632823 | 138458 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -234 | 2 | ChEMBL | 405 | 7 | 1 | 4 | 6.1 | Cc1cc(CCC(=O)O)ccc1-c1ccc(-c2ccc(OC(C)C)c(C#N)c2)s1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL377181 | 138458 | None | 0 | Human | Functional | pEC50 | = | 6.7 | 6.7 | -234 | 2 | ChEMBL | 405 | 7 | 1 | 4 | 6.1 | Cc1cc(CCC(=O)O)ccc1-c1ccc(-c2ccc(OC(C)C)c(C#N)c2)s1 | 10.1016/j.bmcl.2006.04.064 | |||
| 77846755 | 181988 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 381 | 5 | 1 | 3 | 5.2 | Cc1cc(OC2CCCCC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4778961 | 181988 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 381 | 5 | 1 | 3 | 5.2 | Cc1cc(OC2CCCCC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 49835989 | 67926 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -3 | 3 | ChEMBL | 353 | 4 | 0 | 4 | 4.4 | CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3)c2C)C(=O)N1CC | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910681 | 67926 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -3 | 3 | ChEMBL | 353 | 4 | 0 | 4 | 4.4 | CC/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3)c2C)C(=O)N1CC | 10.1016/j.bmcl.2011.09.049 | |||
| 11626664 | 77957 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -239 | 3 | ChEMBL | 455 | 7 | 1 | 6 | 5.1 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2cnc(OC(C)C(F)(F)F)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL209484 | 77957 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -239 | 3 | ChEMBL | 455 | 7 | 1 | 6 | 5.1 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2cnc(OC(C)C(F)(F)F)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 11177439 | 67914 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -239 | 2 | ChEMBL | 413 | 7 | 4 | 3 | 3.6 | N[C@H](CNC(=O)c1cc2c(-c3ccccc3Cc3ccccc3)cccc2[nH]1)C(=O)O | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910654 | 67914 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -239 | 2 | ChEMBL | 413 | 7 | 4 | 3 | 3.6 | N[C@H](CNC(=O)c1cc2c(-c3ccccc3Cc3ccccc3)cccc2[nH]1)C(=O)O | 10.1016/j.bmcl.2011.09.049 | |||
| 66655406 | 167648 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 50 | 2 | ChEMBL | 443 | 7 | 1 | 4 | 5.2 | CC(C)c1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4205333 | 167648 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 50 | 2 | ChEMBL | 443 | 7 | 1 | 4 | 5.2 | CC(C)c1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300295 | 167648 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | 50 | 2 | ChEMBL | 443 | 7 | 1 | 4 | 5.2 | CC(C)c1cccc(Cl)c1COc1ccc2c(c1)OCC21CCN(CCC(=O)O)CC1 | 10.1016/j.bmcl.2017.12.018 | |||
| 66655633 | 167699 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 395 | 3 | 1 | 3 | 3.9 | O=C(O)CCN1CCC2(CC1)COc1cc(C#Cc3ccccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4213894 | 167699 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 395 | 3 | 1 | 3 | 3.9 | O=C(O)CCN1CCC2(CC1)COc1cc(C#Cc3ccccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300915 | 167699 | None | 0 | Human | Functional | pEC50 | = | 7.6 | 7.6 | - | 1 | ChEMBL | 395 | 3 | 1 | 3 | 3.9 | O=C(O)CCN1CCC2(CC1)COc1cc(C#Cc3ccccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 25182621 | 6272 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 4 | 2 | ChEMBL | 326 | 4 | 3 | 5 | 3.5 | Cc1cc(O)ccc1NC(=O)c1cc(NC2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| CHEMBL1081654 | 6272 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | 4 | 2 | ChEMBL | 326 | 4 | 3 | 5 | 3.5 | Cc1cc(O)ccc1NC(=O)c1cc(NC2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| 44412867 | 79773 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -660 | 3 | ChEMBL | 420 | 7 | 1 | 5 | 5.1 | CCOc1ccc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)cc1C(F)(F)F | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL211689 | 79773 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -660 | 3 | ChEMBL | 420 | 7 | 1 | 5 | 5.1 | CCOc1ccc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)cc1C(F)(F)F | 10.1016/j.bmcl.2006.04.084 | |||
| 44412868 | 79795 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -812 | 2 | ChEMBL | 406 | 6 | 1 | 5 | 4.8 | COc1ccc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)cc1C(F)(F)F | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL211806 | 79795 | None | 0 | Human | Functional | pEC50 | = | 5.6 | 5.6 | -812 | 2 | ChEMBL | 406 | 6 | 1 | 5 | 4.8 | COc1ccc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)cc1C(F)(F)F | 10.1016/j.bmcl.2006.04.084 | |||
| 44412908 | 77612 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -109 | 2 | ChEMBL | 318 | 3 | 0 | 3 | 5.8 | Cc1ccccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL208786 | 77612 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -109 | 2 | ChEMBL | 318 | 3 | 0 | 3 | 5.8 | Cc1ccccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 76955634 | 183550 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 383 | 6 | 2 | 3 | 5.3 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4798888 | 183550 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 383 | 6 | 2 | 3 | 5.3 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 11682696 | 79976 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -245 | 3 | ChEMBL | 396 | 8 | 1 | 6 | 4.5 | COc1cc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)ccc1OC(C)C | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL212580 | 79976 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -245 | 3 | ChEMBL | 396 | 8 | 1 | 6 | 4.5 | COc1cc(-c2nc(-c3ccc(CCC(=O)O)cc3C)no2)ccc1OC(C)C | 10.1016/j.bmcl.2006.04.084 | |||
| 69263869 | 104765 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -63 | 4 | ChEMBL | 436 | 6 | 1 | 5 | 6.0 | CCc1cc(-c2noc(-c3sc(C)c4c3C[C@@H]3[C@H]4C3(C)C)n2)cc(C)c1CCC(=O)O | 10.1021/jm4014373 | |||
| CHEMBL3105479 | 104765 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -63 | 4 | ChEMBL | 436 | 6 | 1 | 5 | 6.0 | CCc1cc(-c2noc(-c3sc(C)c4c3C[C@@H]3[C@H]4C3(C)C)n2)cc(C)c1CCC(=O)O | 10.1021/jm4014373 | |||
| 24825339 | 91800 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -66 | 3 | ChEMBL | 392 | 7 | 1 | 7 | 3.8 | Cc1nc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL241052 | 91800 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -66 | 3 | ChEMBL | 392 | 7 | 1 | 7 | 3.8 | Cc1nc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 46866186 | 7333 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -6 | 3 | ChEMBL | 307 | 11 | 2 | 3 | 3.8 | CCCCCCCOc1ccc(CC[C@](C)(N)C(=O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| CHEMBL1086171 | 7333 | None | 0 | Human | Functional | pEC50 | = | 6.6 | 6.6 | -6 | 3 | ChEMBL | 307 | 11 | 2 | 3 | 3.8 | CCCCCCCOc1ccc(CC[C@](C)(N)C(=O)O)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| 44138103 | 75810 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -131 | 4 | ChEMBL | 468 | 5 | 1 | 7 | 5.1 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)cc3n4CCC3CC(=O)O)no2)c1 | 10.1016/j.bmcl.2012.04.129 | |||
| CHEMBL2048293 | 75810 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -131 | 4 | ChEMBL | 468 | 5 | 1 | 7 | 5.1 | N#Cc1cc(OC(F)(F)F)cc(-c2nc(-c3ccc4c(c3)cc3n4CCC3CC(=O)O)no2)c1 | 10.1016/j.bmcl.2012.04.129 | |||
| 44600476 | 57416 | None | 6 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -14 | 3 | ChEMBL | 459 | 6 | 1 | 5 | 5.1 | O=C(O)C1CN(Cc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1 | 10.1021/ml100306h | |||
| CHEMBL1651861 | 57416 | None | 6 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -14 | 3 | ChEMBL | 459 | 6 | 1 | 5 | 5.1 | O=C(O)C1CN(Cc2ccc(-c3nc4ccc(C5(c6ccccc6)CC5)nc4s3)c(F)c2)C1 | 10.1021/ml100306h | |||
| 44412971 | 139021 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -102 | 3 | ChEMBL | 445 | 7 | 1 | 6 | 4.9 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C(F)(F)F)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL378436 | 139021 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -102 | 3 | ChEMBL | 445 | 7 | 1 | 6 | 4.9 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C(F)(F)F)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.5b00928 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.5b00928 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/acs.jmedchem.5b00928 | |||
| 118877433 | 177445 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -14 | 3 | ChEMBL | 459 | 8 | 3 | 4 | 4.5 | COc1ccccc1CC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.8b01695 | |||
| CHEMBL4637401 | 177445 | None | 0 | Human | Functional | pEC50 | = | 8.5 | 8.5 | -14 | 3 | ChEMBL | 459 | 8 | 3 | 4 | 4.5 | COc1ccccc1CC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.8b01695 | |||
| 118877603 | 180535 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 425 | 10 | 3 | 4 | 4.1 | COCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | |||
| CHEMBL4752394 | 180535 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -4 | 3 | ChEMBL | 425 | 10 | 3 | 4 | 4.1 | COCCCCC[C@@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | |||
| 77846507 | 179873 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 437 | 6 | 1 | 3 | 6.4 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CN2CCC(CC(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4744455 | 179873 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | - | 1 | ChEMBL | 437 | 6 | 1 | 3 | 6.4 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CN2CCC(CC(=O)O)C2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 11496072 | 146112 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -32 | 3 | ChEMBL | 448 | 7 | 1 | 5 | 6.1 | Cc1cc(C(C)CC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL391869 | 146112 | None | 0 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -32 | 3 | ChEMBL | 448 | 7 | 1 | 5 | 6.1 | Cc1cc(C(C)CC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 44422601 | 85615 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -8 | 5 | ChEMBL | 398 | 14 | 4 | 3 | 4.2 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL228139 | 85615 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -8 | 5 | ChEMBL | 398 | 14 | 4 | 3 | 4.2 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| 44422605 | 85609 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 2 | 3 | ChEMBL | 329 | 11 | 3 | 3 | 3.1 | CCCCCCc1ccc(OC[C@@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL228103 | 85609 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 2 | 3 | ChEMBL | 329 | 11 | 3 | 3 | 3.1 | CCCCCCc1ccc(OC[C@@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| 66655585 | 167614 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 199 | 2 | ChEMBL | 421 | 5 | 1 | 4 | 4.4 | O=C(O)CN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4209307 | 167614 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 199 | 2 | ChEMBL | 421 | 5 | 1 | 4 | 4.4 | O=C(O)CN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4299904 | 167614 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | 199 | 2 | ChEMBL | 421 | 5 | 1 | 4 | 4.4 | O=C(O)CN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 66655579 | 167652 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 429 | 7 | 1 | 4 | 4.7 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4206573 | 167652 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 429 | 7 | 1 | 4 | 4.7 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300331 | 167652 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 429 | 7 | 1 | 4 | 4.7 | CCc1cccc(Cl)c1COc1ccc2c(c1)OCC21CCCN(CCC(=O)O)C1 | 10.1016/j.bmcl.2017.12.018 | |||
| 145947321 | 167766 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 436 | 6 | 1 | 5 | 4.2 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cc(Cl)nc(Cl)c3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4218094 | 167766 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 436 | 6 | 1 | 5 | 4.2 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cc(Cl)nc(Cl)c3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4301951 | 167766 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 436 | 6 | 1 | 5 | 4.2 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cc(Cl)nc(Cl)c3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 66655208 | 167783 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 401 | 6 | 1 | 4 | 4.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cccc(Cl)c3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4210080 | 167783 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 401 | 6 | 1 | 4 | 4.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cccc(Cl)c3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4302153 | 167783 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | - | 1 | ChEMBL | 401 | 6 | 1 | 4 | 4.1 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3cccc(Cl)c3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 107970 | 1639 | None | 56 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -77 | 5 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2017.12.018 | |||
| 107970.0 | 1639 | None | 56 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -77 | 5 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2017.12.018 | |||
| 2407 | 1639 | None | 56 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -77 | 5 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2017.12.018 | |||
| 4167 | 1639 | None | 56 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -77 | 5 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL314854 | 1639 | None | 56 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -77 | 5 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2017.12.018 | |||
| DB08868 | 1639 | None | 56 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -77 | 5 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2017.12.018 | |||
| 67194420 | 143099 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -645 | 4 | ChEMBL | 468 | 8 | 2 | 8 | 3.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N | nan | |||
| CHEMBL3894716 | 143099 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -645 | 4 | ChEMBL | 468 | 8 | 2 | 8 | 3.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NS(=O)(=O)CCO)no2)cc1C#N | nan | |||
| 25192001 | 8061 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -2 | 4 | ChEMBL | 413 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | |||
| CHEMBL1091103 | 8061 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -2 | 4 | ChEMBL | 413 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc2c(c1)CC[C@@H](C(N)(CO)COP(=O)(O)O)C2 | 10.1016/j.bmcl.2010.02.006 | |||
| 44412604 | 138493 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -10 | 2 | ChEMBL | 405 | 7 | 1 | 4 | 6.1 | Cc1cc(CCC(=O)O)ccc1-c1cc(-c2ccc(OC(C)C)c(C#N)c2)cs1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL377339 | 138493 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -10 | 2 | ChEMBL | 405 | 7 | 1 | 4 | 6.1 | Cc1cc(CCC(=O)O)ccc1-c1cc(-c2ccc(OC(C)C)c(C#N)c2)cs1 | 10.1016/j.bmcl.2006.04.064 | |||
| 44412605 | 139641 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 405 | 7 | 1 | 4 | 6.1 | Cc1cc(CCC(=O)O)ccc1-c1csc(-c2ccc(OC(C)C)c(C#N)c2)c1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL379660 | 139641 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -2 | 2 | ChEMBL | 405 | 7 | 1 | 4 | 6.1 | Cc1cc(CCC(=O)O)ccc1-c1csc(-c2ccc(OC(C)C)c(C#N)c2)c1 | 10.1016/j.bmcl.2006.04.064 | |||
| 46224714 | 201713 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -12 | 2 | ChEMBL | 360 | 2 | 0 | 3 | 4.9 | Cc1nn(C(=O)/C=C/c2cccc(C(F)(F)F)c2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| CHEMBL590134 | 201713 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -12 | 2 | ChEMBL | 360 | 2 | 0 | 3 | 4.9 | Cc1nn(C(=O)/C=C/c2cccc(C(F)(F)F)c2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| 11545181 | 4015 | None | 8 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -1 | 3 | ChEMBL | 370 | 12 | 4 | 3 | 3.4 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N | 10.1016/j.bmc.2006.10.060 | |||
| 2930 | 4015 | None | 8 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -1 | 3 | ChEMBL | 370 | 12 | 4 | 3 | 3.4 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL389033 | 4015 | None | 8 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -1 | 3 | ChEMBL | 370 | 12 | 4 | 3 | 3.4 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N | 10.1016/j.bmc.2006.10.060 | |||
| 90660718 | 60004 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -3 | 3 | ChEMBL | 391 | 4 | 0 | 5 | 3.9 | C/N=C1\S/C(=C/c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1OC | nan | |||
| CHEMBL1734070 | 60004 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -3 | 3 | ChEMBL | 391 | 4 | 0 | 5 | 3.9 | C/N=C1\S/C(=C/c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1OC | nan | |||
| 57400714 | 67932 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -1 | 3 | ChEMBL | 375 | 3 | 0 | 4 | 4.0 | C/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910689 | 67932 | None | 0 | Human | Functional | pEC50 | = | 7.5 | 7.5 | -1 | 3 | ChEMBL | 375 | 3 | 0 | 4 | 4.0 | C/N=C1\S/C(=C\c2cc(C)n(Cc3c(F)cccc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 57390238 | 67925 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -7 | 3 | ChEMBL | 377 | 2 | 0 | 4 | 4.4 | C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(Cl)cc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910680 | 67925 | None | 0 | Human | Functional | pEC50 | = | 5.5 | 5.5 | -7 | 3 | ChEMBL | 377 | 2 | 0 | 4 | 4.4 | C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(Cl)cc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 46224768 | 201755 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -20 | 3 | ChEMBL | 293 | 2 | 0 | 4 | 3.2 | Cc1nn(C(=O)/C=C/c2cccnc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| CHEMBL590384 | 201755 | None | 0 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -20 | 3 | ChEMBL | 293 | 2 | 0 | 4 | 3.2 | Cc1nn(C(=O)/C=C/c2cccnc2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| 77846675 | 179521 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 457 | 5 | 1 | 3 | 6.8 | CC(C)(C)[C@H]1CC[C@H](Oc2cc(Cl)c3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4740175 | 179521 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 457 | 5 | 1 | 3 | 6.8 | CC(C)(C)[C@H]1CC[C@H](Oc2cc(Cl)c3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| 46881877 | 7107 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -5 | 4 | ChEMBL | 359 | 13 | 2 | 5 | 3.8 | CCCCCCCOc1ccc(CC[C@](C)(N)CCc2nnn[nH]2)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| CHEMBL1085191 | 7107 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -5 | 4 | ChEMBL | 359 | 13 | 2 | 5 | 3.8 | CCCCCCCOc1ccc(CC[C@](C)(N)CCc2nnn[nH]2)cc1 | 10.1016/j.bmcl.2010.01.118 | |||
| 57398998 | 67934 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 3 | 3 | ChEMBL | 375 | 3 | 0 | 4 | 4.0 | C/N=C1\S/C(=C\c2cc(C)n(Cc3ccc(F)cc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910691 | 67934 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 3 | 3 | ChEMBL | 375 | 3 | 0 | 4 | 4.0 | C/N=C1\S/C(=C\c2cc(C)n(Cc3ccc(F)cc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 44439852 | 93899 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -47 | 2 | ChEMBL | 403 | 6 | 1 | 6 | 4.6 | Cc1cc([C@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL247766 | 93899 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -47 | 2 | ChEMBL | 403 | 6 | 1 | 6 | 4.6 | Cc1cc([C@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 77847766 | 181619 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 451 | 5 | 1 | 3 | 6.8 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CN2CCC(C)(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4765011 | 181619 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | - | 1 | ChEMBL | 451 | 5 | 1 | 3 | 6.8 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CN2CCC(C)(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 58344502 | 142932 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -398 | 2 | ChEMBL | 459 | 5 | 2 | 7 | 3.4 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4NC(=O)N3CC(O)C3)no2)cc1C#N | nan | |||
| CHEMBL3893172 | 142932 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -398 | 2 | ChEMBL | 459 | 5 | 2 | 7 | 3.4 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4NC(=O)N3CC(O)C3)no2)cc1C#N | nan | |||
| 66655999 | 167754 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 361 | 3 | 1 | 3 | 3.3 | O=C(O)CCN1CCC2(CC1)COc1cc(C#Cc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4208055 | 167754 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 361 | 3 | 1 | 3 | 3.3 | O=C(O)CCN1CCC2(CC1)COc1cc(C#Cc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4301752 | 167754 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | - | 1 | ChEMBL | 361 | 3 | 1 | 3 | 3.3 | O=C(O)CCN1CCC2(CC1)COc1cc(C#Cc3ccccc3)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmc.2006.10.060 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmc.2006.10.060 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmc.2006.10.060 | |||
| 46872626 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 74 | 2 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| 9496 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 74 | 2 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741589 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 74 | 2 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| 52938427 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 10.1016/j.bmcl.2019.06.042 | |||
| 52938427.0 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 10.1016/j.bmcl.2019.06.042 | |||
| 5383 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 10.1016/j.bmcl.2019.06.042 | |||
| 8709 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 10.1016/j.bmcl.2019.06.042 | |||
| CHEMBL3707247 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 10.1016/j.bmcl.2019.06.042 | |||
| DB12612 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.4 | 8.4 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 10.1016/j.bmcl.2019.06.042 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm050242f | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm050242f | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm050242f | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -4 | 7 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm050242f | |||
| 118877584 | 182559 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -7 | 3 | ChEMBL | 411 | 9 | 3 | 4 | 3.7 | CCOCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | |||
| CHEMBL4786296 | 182559 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -7 | 3 | ChEMBL | 411 | 9 | 3 | 4 | 3.7 | CCOCCC[C@H]1CCc2cc([C@H]3CC[C@](N)(COP(=O)(O)O)C3)ccc2C1 | 10.1021/acs.jmedchem.0c01109 | |||
| 24825338 | 77739 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -467 | 3 | ChEMBL | 434 | 7 | 1 | 5 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL208924 | 77739 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -467 | 3 | ChEMBL | 434 | 7 | 1 | 5 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 24825338 | 77739 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -467 | 3 | ChEMBL | 434 | 7 | 1 | 5 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL208924 | 77739 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -467 | 3 | ChEMBL | 434 | 7 | 1 | 5 | 5.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 44412854 | 166026 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -4 | 2 | ChEMBL | 376 | 5 | 1 | 4 | 5.4 | Cc1cc(CC(=O)O)ccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL425058 | 166026 | None | 0 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -4 | 2 | ChEMBL | 376 | 5 | 1 | 4 | 5.4 | Cc1cc(CC(=O)O)ccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 90318298 | 179687 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 371 | 13 | 2 | 3 | 5.5 | CCCCCCCCOc1cc(C)c2ccccc2c1CNCCC(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4742052 | 179687 | None | 0 | Human | Functional | pEC50 | = | 6.4 | 6.4 | - | 1 | ChEMBL | 371 | 13 | 2 | 3 | 5.5 | CCCCCCCCOc1cc(C)c2ccccc2c1CNCCC(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| 44422579 | 85614 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -1 | 3 | ChEMBL | 356 | 13 | 4 | 3 | 3.9 | CCCCCCCCc1cccc(NC[C@H](N)CCP(=O)(O)O)c1 | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL228138 | 85614 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -1 | 3 | ChEMBL | 356 | 13 | 4 | 3 | 3.9 | CCCCCCCCc1cccc(NC[C@H](N)CCP(=O)(O)O)c1 | 10.1016/j.bmc.2006.10.060 | |||
| 44412578 | 78161 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -26 | 2 | ChEMBL | 391 | 7 | 1 | 7 | 3.3 | Cc1cc(CCC(=O)O)ccc1-c1nnn(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL210345 | 78161 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -26 | 2 | ChEMBL | 391 | 7 | 1 | 7 | 3.3 | Cc1cc(CCC(=O)O)ccc1-c1nnn(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| 11575913 | 78151 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 5 | 2 | ChEMBL | 444 | 7 | 1 | 5 | 5.3 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(Br)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL210316 | 78151 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | 5 | 2 | ChEMBL | 444 | 7 | 1 | 5 | 5.3 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(Br)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 54764919 | 69923 | None | 32 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -229 | 5 | ChEMBL | 415 | 4 | 2 | 4 | 4.7 | COc1ccncc1C(=O)NC(=O)Nc1ccc(-c2ccccc2)c(C(F)(F)F)c1 | 10.1021/ml2001399 | |||
| CHEMBL1938952 | 69923 | None | 32 | Human | Functional | pEC50 | = | 5.4 | 5.4 | -229 | 5 | ChEMBL | 415 | 4 | 2 | 4 | 4.7 | COc1ccncc1C(=O)NC(=O)Nc1ccc(-c2ccccc2)c(C(F)(F)F)c1 | 10.1021/ml2001399 | |||
| 16038017 | 139505 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -398 | 3 | ChEMBL | 431 | 7 | 1 | 6 | 4.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OCC(F)(F)F)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL379380 | 139505 | None | 0 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -398 | 3 | ChEMBL | 431 | 7 | 1 | 6 | 4.5 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OCC(F)(F)F)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 52938426 | 3376 | None | 13 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -69 | 5 | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N | nan | |||
| 9889 | 3376 | None | 13 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -69 | 5 | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N | nan | |||
| CHEMBL3899384 | 3376 | None | 13 | Human | Functional | pEC50 | = | 7.4 | 7.4 | -69 | 5 | ChEMBL | 360 | 4 | 1 | 6 | 4.0 | N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N | nan | |||
| 44412621 | 78429 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -416 | 2 | ChEMBL | 391 | 7 | 1 | 6 | 4.4 | Cc1cc(CCC(=O)O)ccc1-c1nnc(-c2ccc(OC(C)C)c(C#N)c2)o1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL211081 | 78429 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -416 | 2 | ChEMBL | 391 | 7 | 1 | 6 | 4.4 | Cc1cc(CCC(=O)O)ccc1-c1nnc(-c2ccc(OC(C)C)c(C#N)c2)o1 | 10.1016/j.bmcl.2006.04.064 | |||
| 44422606 | 85607 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 2 | 5 | ChEMBL | 329 | 11 | 3 | 3 | 3.1 | CCCCCCc1ccc(OC[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL228049 | 85607 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 2 | 5 | ChEMBL | 329 | 11 | 3 | 3 | 3.1 | CCCCCCc1ccc(OC[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| 44342175 | 85554 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -2 | 4 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL227371 | 85554 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -2 | 4 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL422074 | 85554 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -2 | 4 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| 67196597 | 148051 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -562 | 2 | ChEMBL | 482 | 9 | 1 | 8 | 3.6 | COCCS(=O)(=O)N[C@@H]1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21 | nan | |||
| CHEMBL3933952 | 148051 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -562 | 2 | ChEMBL | 482 | 9 | 1 | 8 | 3.6 | COCCS(=O)(=O)N[C@@H]1CCc2c(-c3noc(-c4ccc(OC(C)C)c(C#N)c4)n3)cccc21 | nan | |||
| 44439850 | 146115 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -24 | 3 | ChEMBL | 446 | 6 | 1 | 5 | 5.7 | Cc1cc([C@@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL391870 | 146115 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -24 | 3 | ChEMBL | 446 | 6 | 1 | 5 | 5.7 | Cc1cc([C@@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 44439851 | 145735 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -37 | 3 | ChEMBL | 403 | 6 | 1 | 6 | 4.6 | Cc1cc([C@@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL391581 | 145735 | None | 0 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -37 | 3 | ChEMBL | 403 | 6 | 1 | 6 | 4.6 | Cc1cc([C@@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 46872626 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| 9496 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741589 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| 44438259 | 93880 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 44438260 | 93880 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| CHEMBL247699 | 93880 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 2 | 2 | ChEMBL | 399 | 12 | 4 | 4 | 3.5 | CCCCCCCCc1ccc([C@@H]2C[C@@H](COP(=O)(O)O)N[C@H]2CO)cc1 | 10.1016/j.bmcl.2006.10.014 | |||
| 44406009 | 72734 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -10 | 4 | ChEMBL | 515 | 18 | 5 | 10 | 3.4 | N[C@@H](COP(=O)(O)O)[C@H](O)/C=C/CCCCCCCCCCNc1ccc([N+](=O)[O-])c2nonc12 | 10.1016/j.bmcl.2005.09.038 | |||
| CHEMBL199754 | 72734 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -10 | 4 | ChEMBL | 515 | 18 | 5 | 10 | 3.4 | N[C@@H](COP(=O)(O)O)[C@H](O)/C=C/CCCCCCCCCCNc1ccc([N+](=O)[O-])c2nonc12 | 10.1016/j.bmcl.2005.09.038 | |||
| 46224769 | 203299 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -251 | 4 | ChEMBL | 331 | 2 | 1 | 3 | 4.3 | Cc1nn(C(=O)/C=C/c2cccc3[nH]ccc23)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| CHEMBL601062 | 203299 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -251 | 4 | ChEMBL | 331 | 2 | 1 | 3 | 4.3 | Cc1nn(C(=O)/C=C/c2cccc3[nH]ccc23)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| 57397320 | 67931 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 3 | ChEMBL | 357 | 3 | 0 | 4 | 3.8 | C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910688 | 67931 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 3 | ChEMBL | 357 | 3 | 0 | 4 | 3.8 | C/N=C1\S/C(=C\c2cc(C)n(Cc3ccccc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 11588811 | 4012 | None | 37 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 4 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N | 10.1016/j.bmc.2006.10.060 | |||
| 136212600 | 4012 | None | 37 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 4 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N | 10.1016/j.bmc.2006.10.060 | |||
| 3324 | 4012 | None | 37 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 4 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL228102 | 4012 | None | 37 | Human | Functional | pEC50 | = | 7.3 | 7.3 | 1 | 4 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](COP(=O)(O)O)N | 10.1016/j.bmc.2006.10.060 | |||
| 11501873 | 140234 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -275 | 3 | ChEMBL | 384 | 7 | 1 | 5 | 4.7 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(F)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL380253 | 140234 | None | 0 | Human | Functional | pEC50 | = | 6.3 | 6.3 | -275 | 3 | ChEMBL | 384 | 7 | 1 | 5 | 4.7 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(F)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 52938427 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | nan | |||
| 52938427.0 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | nan | |||
| 5383 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | nan | |||
| 8709 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | nan | |||
| CHEMBL3707247 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | nan | |||
| DB12612 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | ChEMBL | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | nan | |||
| 25110382 | 146197 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -354 | 5 | ChEMBL | 366 | 6 | 1 | 6 | 4.2 | CCOc1ccc(-c2nc(-c3cccc4c3CCC4O)no2)cc1OCC | nan | |||
| CHEMBL3919445 | 146197 | None | 0 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -354 | 5 | ChEMBL | 366 | 6 | 1 | 6 | 4.2 | CCOc1ccc(-c2nc(-c3cccc4c3CCC4O)no2)cc1OCC | nan | |||
| 58344715 | 143160 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -575 | 2 | ChEMBL | 468 | 8 | 2 | 8 | 3.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4NS(=O)(=O)CCO)no2)cc1C#N | nan | |||
| CHEMBL3895230 | 143160 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -575 | 2 | ChEMBL | 468 | 8 | 2 | 8 | 3.0 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@@H]4NS(=O)(=O)CCO)no2)cc1C#N | nan | |||
| 11224984 | 8719 | None | 24 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -13 | 4 | ChEMBL | 460 | 8 | 2 | 6 | 4.3 | CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C | 10.1021/jm100181s | |||
| CHEMBL1095833 | 8719 | None | 24 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -13 | 4 | ChEMBL | 460 | 8 | 2 | 6 | 4.3 | CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C | 10.1021/jm100181s | |||
| 44412882 | 77317 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -1174 | 3 | ChEMBL | 390 | 6 | 1 | 4 | 5.8 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL208168 | 77317 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -1174 | 3 | ChEMBL | 390 | 6 | 1 | 4 | 5.8 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/acs.jmedchem.3c00498 | |||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/acs.jmedchem.3c00498 | |||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/acs.jmedchem.3c00498 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/acs.jmedchem.3c00498 | |||
| 25182926 | 7943 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 3 | 3 | ChEMBL | 451 | 11 | 3 | 6 | 3.8 | O=C(O)CCNCc1ccc(NC(=O)c2cc(N(CC3CC3)C3CCCCC3)ncn2)cc1 | 10.1016/j.bmcl.2010.01.102 | |||
| CHEMBL1090423 | 7943 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 3 | 3 | ChEMBL | 451 | 11 | 3 | 6 | 3.8 | O=C(O)CCNCc1ccc(NC(=O)c2cc(N(CC3CC3)C3CCCCC3)ncn2)cc1 | 10.1016/j.bmcl.2010.01.102 | |||
| 66655775 | 167785 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 158 | 2 | ChEMBL | 453 | 6 | 1 | 4 | 4.9 | O=C(O)CCN1CCC2(CC1)COc1c2ccc(OCc2c(Cl)cccc2Cl)c1F | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4208771 | 167785 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 158 | 2 | ChEMBL | 453 | 6 | 1 | 4 | 4.9 | O=C(O)CCN1CCC2(CC1)COc1c2ccc(OCc2c(Cl)cccc2Cl)c1F | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4302165 | 167785 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 158 | 2 | ChEMBL | 453 | 6 | 1 | 4 | 4.9 | O=C(O)CCN1CCC2(CC1)COc1c2ccc(OCc2c(Cl)cccc2Cl)c1F | 10.1016/j.bmcl.2017.12.018 | |||
| 11689680 | 79671 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -102 | 3 | ChEMBL | 391 | 7 | 1 | 6 | 4.4 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL211505 | 79671 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -102 | 3 | ChEMBL | 391 | 7 | 1 | 6 | 4.4 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 11689680 | 79671 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -102 | 3 | ChEMBL | 391 | 7 | 1 | 6 | 4.4 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL211505 | 79671 | None | 0 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -102 | 3 | ChEMBL | 391 | 7 | 1 | 6 | 4.4 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 90318624 | 181441 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 423 | 5 | 1 | 3 | 6.1 | CC(C)(C)[C@H]1CC[C@H](Oc2ccc3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4762836 | 181441 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | - | 1 | ChEMBL | 423 | 5 | 1 | 3 | 6.1 | CC(C)(C)[C@H]1CC[C@H](Oc2ccc3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| 57395471 | 67942 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -58 | 3 | ChEMBL | 389 | 4 | 0 | 4 | 4.7 | CC/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CC | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910800 | 67942 | None | 0 | Human | Functional | pEC50 | = | 5.2 | 5.2 | -58 | 3 | ChEMBL | 389 | 4 | 0 | 4 | 4.7 | CC/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3F)c2C)C(=O)N1CC | 10.1016/j.bmcl.2011.09.049 | |||
| 45377662 | 84151 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -204 | 4 | ChEMBL | 468 | 9 | 1 | 6 | 4.3 | CCCCN(C(=O)c1ccccc1F)c1nnc(-c2ccc(CN3CC(C(=O)O)C3)cc2)s1 | 10.1016/j.bmcl.2012.09.110 | |||
| CHEMBL2207778 | 84151 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -204 | 4 | ChEMBL | 468 | 9 | 1 | 6 | 4.3 | CCCCN(C(=O)c1ccccc1F)c1nnc(-c2ccc(CN3CC(C(=O)O)C3)cc2)s1 | 10.1016/j.bmcl.2012.09.110 | |||
| 56601979 | 167769 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 19 | 2 | ChEMBL | 449 | 6 | 1 | 4 | 5.0 | CC(CN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12)C(=O)O | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4217349 | 167769 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 19 | 2 | ChEMBL | 449 | 6 | 1 | 4 | 5.0 | CC(CN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12)C(=O)O | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4301966 | 167769 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 19 | 2 | ChEMBL | 449 | 6 | 1 | 4 | 5.0 | CC(CN1CCC2(CC1)COc1cc(OCc3c(Cl)cccc3Cl)ccc12)C(=O)O | 10.1016/j.bmcl.2017.12.018 | |||
| 66655050 | 167801 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 100 | 2 | ChEMBL | 419 | 6 | 1 | 4 | 4.3 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(F)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4207361 | 167801 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 100 | 2 | ChEMBL | 419 | 6 | 1 | 4 | 4.3 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(F)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4302356 | 167801 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | 100 | 2 | ChEMBL | 419 | 6 | 1 | 4 | 4.3 | O=C(O)CCN1CCC2(CC1)COc1cc(OCc3c(F)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 11452022 | 3596 | None | 37 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm200609t | |||
| 6996 | 3596 | None | 37 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm200609t | |||
| CHEMBL366208 | 3596 | None | 37 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -3 | 6 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CC[C@@](COP(=O)(O)O)(CO)N | 10.1021/jm200609t | |||
| 57398996 | 67922 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -1 | 3 | ChEMBL | 343 | 2 | 0 | 4 | 3.8 | C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910674 | 67922 | None | 0 | Human | Functional | pEC50 | = | 6.2 | 6.2 | -1 | 3 | ChEMBL | 343 | 2 | 0 | 4 | 3.8 | C/N=C1\S/C(=C\c2cc(C)n(-c3ccc(F)cc3)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 77846591 | 181991 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 451 | 7 | 1 | 3 | 6.8 | CCC(C)(C)[C@H]1CC[C@H](Oc2cc(C)c3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4779029 | 181991 | None | 0 | Human | Functional | pEC50 | = | 7.2 | 7.2 | - | 1 | ChEMBL | 451 | 7 | 1 | 3 | 6.8 | CCC(C)(C)[C@H]1CC[C@H](Oc2cc(C)c3ccccc3c2CN2CCC(C(=O)O)CC2)CC1 | 10.1021/acsmedchemlett.0c00631 | |||
| 66655836 | 167658 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 39 | 2 | ChEMBL | 449 | 6 | 1 | 4 | 5.1 | Cc1cc(Cl)c(COc2ccc3c(c2)OCC32CCN(CCC(=O)O)CC2)c(Cl)c1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4213167 | 167658 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 39 | 2 | ChEMBL | 449 | 6 | 1 | 4 | 5.1 | Cc1cc(Cl)c(COc2ccc3c(c2)OCC32CCN(CCC(=O)O)CC2)c(Cl)c1 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4300404 | 167658 | None | 0 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 39 | 2 | ChEMBL | 449 | 6 | 1 | 4 | 5.1 | Cc1cc(Cl)c(COc2ccc3c(c2)OCC32CCN(CCC(=O)O)CC2)c(Cl)c1 | 10.1016/j.bmcl.2017.12.018 | |||
| 1776080 | 67915 | None | 5 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -3 | 3 | ChEMBL | 343 | 2 | 0 | 4 | 3.8 | C/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910655 | 67915 | None | 5 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -3 | 3 | ChEMBL | 343 | 2 | 0 | 4 | 3.8 | C/N=C1\S/C(=C\c2cc(C)n(-c3ccccc3F)c2C)C(=O)N1C | 10.1016/j.bmcl.2011.09.049 | |||
| 11603726 | 76858 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -588 | 3 | ChEMBL | 400 | 7 | 1 | 5 | 5.2 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL206940 | 76858 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -588 | 3 | ChEMBL | 400 | 7 | 1 | 5 | 5.2 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| 44422573 | 85590 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -2 | 4 | ChEMBL | 370 | 12 | 4 | 3 | 3.4 | CCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| CHEMBL227851 | 85590 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -2 | 4 | ChEMBL | 370 | 12 | 4 | 3 | 3.4 | CCCCCCCCc1ccc(NC(=O)[C@H](N)CCP(=O)(O)O)cc1 | 10.1016/j.bmc.2006.10.060 | |||
| 58344692 | 145010 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -758 | 3 | ChEMBL | 459 | 5 | 2 | 7 | 3.4 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NC(=O)N3CC(O)C3)no2)cc1C#N | nan | |||
| CHEMBL3910269 | 145010 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -758 | 3 | ChEMBL | 459 | 5 | 2 | 7 | 3.4 | CC(C)Oc1ccc(-c2nc(-c3cccc4c3CC[C@H]4NC(=O)N3CC(O)C3)no2)cc1C#N | nan | |||
| 145948099 | 167820 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 469 | 5 | 1 | 5 | 3.8 | O=C(O)CN1CCC2(CC1)COc1cc(S(=O)(=O)Cc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4209494 | 167820 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 469 | 5 | 1 | 5 | 3.8 | O=C(O)CN1CCC2(CC1)COc1cc(S(=O)(=O)Cc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| CHEMBL4302573 | 167820 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | - | 1 | ChEMBL | 469 | 5 | 1 | 5 | 3.8 | O=C(O)CN1CCC2(CC1)COc1cc(S(=O)(=O)Cc3c(Cl)cccc3Cl)ccc12 | 10.1016/j.bmcl.2017.12.018 | |||
| 136212602 | 11757 | None | 7 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 2 | 3 | ChEMBL | 369 | 11 | 4 | 4 | 3.6 | CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 | 10.1016/j.bmcl.2011.09.049 | |||
| 44394498 | 11757 | None | 7 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 2 | 3 | ChEMBL | 369 | 11 | 4 | 4 | 3.6 | CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1181619 | 11757 | None | 7 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 2 | 3 | ChEMBL | 369 | 11 | 4 | 4 | 3.6 | CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 | 10.1016/j.bmcl.2011.09.049 | |||
| CHEMBL1910653 | 11757 | None | 7 | Human | Functional | pEC50 | = | 8.1 | 8.1 | 2 | 3 | ChEMBL | 369 | 11 | 4 | 4 | 3.6 | CCCCCCCCc1ccc2nc([C@@H](N)COP(=O)(O)O)[nH]c2c1 | 10.1016/j.bmcl.2011.09.049 | |||
| 46224715 | 201714 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -7 | 4 | ChEMBL | 371 | 3 | 1 | 5 | 2.5 | Cc1nn(C(=O)/C=C/c2cccc(S(N)(=O)=O)c2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| CHEMBL590135 | 201714 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -7 | 4 | ChEMBL | 371 | 3 | 1 | 5 | 2.5 | Cc1nn(C(=O)/C=C/c2cccc(S(N)(=O)=O)c2)c2c1[C@H]1[C@@H](C2)C1(C)C | 10.1016/j.bmcl.2009.11.045 | |||
| 11611053 | 77972 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -912 | 3 | ChEMBL | 401 | 7 | 1 | 5 | 4.9 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(C(F)(F)C(C)C)cn2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL209567 | 77972 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -912 | 3 | ChEMBL | 401 | 7 | 1 | 5 | 4.9 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2ccc(C(F)(F)C(C)C)cn2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 44412883 | 77326 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -58 | 3 | ChEMBL | 404 | 7 | 1 | 4 | 6.2 | Cc1cc(CCCC(=O)O)ccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL208224 | 77326 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -58 | 3 | ChEMBL | 404 | 7 | 1 | 4 | 6.2 | Cc1cc(CCCC(=O)O)ccc1-c1noc(-c2ccc(C3CCCCC3)cc2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 44547414 | 68365 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -67 | 6 | ChEMBL | 499 | 5 | 1 | 5 | 5.2 | O=C(O)CCC(=O)N1CCc2cc(-c3noc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)ccc21 | 10.1016/j.bmcl.2011.05.110 | |||
| CHEMBL1916559 | 68365 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -67 | 6 | ChEMBL | 499 | 5 | 1 | 5 | 5.2 | O=C(O)CCC(=O)N1CCc2cc(-c3noc(-c4cc(C(F)(F)F)cc(C(F)(F)F)c4)n3)ccc21 | 10.1016/j.bmcl.2011.05.110 | |||
| 44439851 | 145735 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -37 | 3 | ChEMBL | 403 | 6 | 1 | 6 | 4.6 | Cc1cc([C@@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL391581 | 145735 | None | 0 | Human | Functional | pEC50 | = | 7.1 | 7.1 | -37 | 3 | ChEMBL | 403 | 6 | 1 | 6 | 4.6 | Cc1cc([C@@H]2C[C@H]2C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C#N)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 11662328 | 91799 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -33 | 3 | ChEMBL | 448 | 7 | 1 | 5 | 5.8 | Cc1cc(CC(C)C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| CHEMBL241050 | 91799 | None | 0 | Human | Functional | pEC50 | = | 8 | 8.0 | -33 | 3 | ChEMBL | 448 | 7 | 1 | 5 | 5.8 | Cc1cc(CC(C)C(=O)O)ccc1-c1noc(-c2ccc(OC(C)C)c(C(F)(F)F)c2)n1 | 10.1016/j.bmcl.2006.10.057 | |||
| 46224712 | 203258 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -35 | 2 | ChEMBL | 352 | 4 | 0 | 5 | 3.9 | COc1ccc(/C=C/C(=O)n2nc(C)c3c2C[C@@H]2[C@H]3C2(C)C)cc1OC | 10.1016/j.bmcl.2009.11.045 | |||
| CHEMBL600762 | 203258 | None | 0 | Human | Functional | pEC50 | = | 6.1 | 6.1 | -35 | 2 | ChEMBL | 352 | 4 | 0 | 5 | 3.9 | COc1ccc(/C=C/C(=O)n2nc(C)c3c2C[C@@H]2[C@H]3C2(C)C)cc1OC | 10.1016/j.bmcl.2009.11.045 | |||
| 11697013 | 78292 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -1318 | 3 | ChEMBL | 401 | 7 | 1 | 6 | 4.6 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2cnc(OC(C)C)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| CHEMBL210695 | 78292 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -1318 | 3 | ChEMBL | 401 | 7 | 1 | 6 | 4.6 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2cnc(OC(C)C)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.064 | |||
| 11697013 | 78292 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -1318 | 3 | ChEMBL | 401 | 7 | 1 | 6 | 4.6 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2cnc(OC(C)C)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| CHEMBL210695 | 78292 | None | 0 | Human | Functional | pEC50 | = | 6.0 | 6.0 | -1318 | 3 | ChEMBL | 401 | 7 | 1 | 6 | 4.6 | Cc1cc(CCC(=O)O)ccc1-c1noc(-c2cnc(OC(C)C)c(Cl)c2)n1 | 10.1016/j.bmcl.2006.04.084 | |||
| 25182773 | 7628 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -53 | 3 | ChEMBL | 443 | 7 | 2 | 6 | 3.2 | Cc1cc(S(N)(=O)=O)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| CHEMBL1088177 | 7628 | None | 0 | Human | Functional | pEC50 | = | 7.0 | 7.0 | -53 | 3 | ChEMBL | 443 | 7 | 2 | 6 | 3.2 | Cc1cc(S(N)(=O)=O)ccc1NC(=O)c1cc(N(CC2CC2)C2CCCCC2)ncn1 | 10.1016/j.bmcl.2010.01.102 | |||
| 44607575 | 52563 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -69 | 5 | ChEMBL | 375 | 4 | 1 | 3 | 5.8 | COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | nan | |||
| CHEMBL1592119 | 52563 | None | 0 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -69 | 5 | ChEMBL | 375 | 4 | 1 | 3 | 5.8 | COc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | nan | |||
| 44607577 | 43907 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -120 | 2 | ChEMBL | 415 | 5 | 1 | 2 | 7.8 | CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | nan | |||
| CHEMBL1511839 | 43907 | None | 0 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -120 | 2 | ChEMBL | 415 | 5 | 1 | 2 | 7.8 | CC(C)c1cccc(C(C)C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | nan | |||
| 2328694 | 53744 | None | 2 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -8 | 5 | ChEMBL | 408 | 6 | 2 | 3 | 5.2 | O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 | nan | |||
| CHEMBL1603615 | 53744 | None | 2 | Human | Functional | pIC50 | = | 5.9 | 5.9 | -8 | 5 | ChEMBL | 408 | 6 | 2 | 3 | 5.2 | O=C(Nc1ccccc1)Nc1cc(OCC(F)(F)F)cc(OCC(F)(F)F)c1 | nan | |||
| 46872388 | 136858 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 303 | 8 | 1 | 3 | 3.4 | CCCCCC(=O)c1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741172 | 136858 | None | 0 | Human | Functional | pIC50 | = | 7.9 | 7.9 | - | 1 | ChEMBL | 303 | 8 | 1 | 3 | 3.4 | CCCCCC(=O)c1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 4492589 | 30916 | None | 3 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -181 | 4 | ChEMBL | 359 | 3 | 1 | 2 | 6.1 | Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | 10.1016/j.bmcl.2011.06.132 | |||
| CHEMBL1397874 | 30916 | None | 3 | Human | Functional | pIC50 | = | 4.9 | 4.9 | -181 | 4 | ChEMBL | 359 | 3 | 1 | 2 | 6.1 | Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | 10.1016/j.bmcl.2011.06.132 | |||
| 44607578 | 52363 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | -45 | 2 | ChEMBL | 379 | 7 | 1 | 4 | 5.5 | CCOc1ccc(OC)cc1-c1ccc(C(=O)Nc2c(C)cccc2CC)o1 | nan | |||
| CHEMBL1589684 | 52363 | None | 0 | Human | Functional | pIC50 | = | 4.7 | 4.7 | -45 | 2 | ChEMBL | 379 | 7 | 1 | 4 | 5.5 | CCOc1ccc(OC)cc1-c1ccc(C(=O)Nc2c(C)cccc2CC)o1 | nan | |||
| 59451874 | 136733 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 289 | 8 | 1 | 3 | 3.0 | CCCCCC(=O)c1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740009 | 136733 | None | 0 | Human | Functional | pIC50 | = | 8.7 | 8.7 | - | 1 | ChEMBL | 289 | 8 | 1 | 3 | 3.0 | CCCCCC(=O)c1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 46872386 | 136683 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 323 | 6 | 1 | 3 | 3.0 | O=C(Cc1ccccc1)c1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739593 | 136683 | None | 0 | Human | Functional | pIC50 | = | 6.6 | 6.6 | - | 1 | ChEMBL | 323 | 6 | 1 | 3 | 3.0 | O=C(Cc1ccccc1)c1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451795 | 136793 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 309 | 6 | 1 | 3 | 2.6 | O=C(Cc1ccccc1)c1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740604 | 136793 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | - | 1 | ChEMBL | 309 | 6 | 1 | 3 | 2.6 | O=C(Cc1ccccc1)c1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 6217704 | 32591 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 7 | 6 | ChEMBL | 490 | 7 | 0 | 8 | 5.2 | CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 | nan | |||
| CHEMBL1412583 | 32591 | None | 0 | Human | Functional | pIC50 | = | 7.5 | 7.5 | 7 | 6 | ChEMBL | 490 | 7 | 0 | 8 | 5.2 | CCOC(=O)/C(=C\c1ccc(OC(F)F)cc1)C1=Nn2c(nnc2-c2ccc(Cl)cc2)SC1 | nan | |||
| 59451808 | 136833 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 317 | 9 | 1 | 3 | 3.7 | CCCCCCC(=O)c1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740964 | 136833 | None | 0 | Human | Functional | pIC50 | = | 8.3 | 8.3 | - | 1 | ChEMBL | 317 | 9 | 1 | 3 | 3.7 | CCCCCCC(=O)c1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 46872389 | 136716 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 303 | 9 | 1 | 3 | 3.4 | CCCCCCC(=O)c1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739887 | 136716 | None | 0 | Human | Functional | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 303 | 9 | 1 | 3 | 3.4 | CCCCCCC(=O)c1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451857 | 136752 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 391 | 6 | 1 | 3 | 4.3 | O=C(Cc1ccc(Cl)c(Cl)c1)c1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740180 | 136752 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 391 | 6 | 1 | 3 | 4.3 | O=C(Cc1ccc(Cl)c(Cl)c1)c1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451852 | 136949 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 377 | 6 | 1 | 3 | 3.9 | O=C(Cc1ccc(Cl)c(Cl)c1)c1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741988 | 136949 | None | 0 | Human | Functional | pIC50 | = | 8.1 | 8.1 | - | 1 | ChEMBL | 377 | 6 | 1 | 3 | 3.9 | O=C(Cc1ccc(Cl)c(Cl)c1)c1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 1363299 | 32951 | None | 7 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -37 | 5 | ChEMBL | 359 | 3 | 1 | 2 | 6.1 | Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 | nan | |||
| CHEMBL1415555 | 32951 | None | 7 | Human | Functional | pIC50 | = | 5.0 | 5.0 | -37 | 5 | ChEMBL | 359 | 3 | 1 | 2 | 6.1 | Cc1cccc(C)c1NC(=O)c1ccc(-c2ccc(Cl)cc2Cl)o1 | nan | |||
| 71450073 | 82621 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -288 | 4 | ChEMBL | 585 | 10 | 2 | 5 | 5.5 | Cc1cc(S(=O)(=O)Nc2cccc(-c3cc(C)c(C(=O)N(C)[C@@H](CCN(C)C)C(=O)O)c(C)c3)c2)c(C)cc1Cl | 10.1021/jm3009508 | |||
| CHEMBL2178814 | 82621 | None | 0 | Human | Functional | pIC50 | = | 6.0 | 6.0 | -288 | 4 | ChEMBL | 585 | 10 | 2 | 5 | 5.5 | Cc1cc(S(=O)(=O)Nc2cccc(-c3cc(C)c(C(=O)N(C)[C@@H](CCN(C)C)C(=O)O)c(C)c3)c2)c(C)cc1Cl | 10.1021/jm3009508 | |||
| 11363176 | 3149 | None | 41 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 4 | Drug Central | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | None | |||
| 11363176.0 | 3149 | None | 41 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 4 | Drug Central | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | None | |||
| 5446 | 3149 | None | 41 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 4 | Drug Central | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | None | |||
| 9320 | 3149 | None | 41 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 4 | Drug Central | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | None | |||
| CHEMBL1096146 | 3149 | None | 41 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 4 | Drug Central | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | None | |||
| DB12016 | 3149 | None | 41 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 4 | Drug Central | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | None | |||
| 52938427 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -26 | 6 | Drug Central | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| 52938427.0 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -26 | 6 | Drug Central | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| 5383 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -26 | 6 | Drug Central | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| 8709 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -26 | 6 | Drug Central | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| CHEMBL3707247 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -26 | 6 | Drug Central | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| DB12612 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -26 | 6 | Drug Central | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| 44599207 | 3609 | None | 35 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 5 | Drug Central | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | None | |||
| 44599207.0 | 3609 | None | 35 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 5 | Drug Central | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | None | |||
| 5326 | 3609 | None | 35 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 5 | Drug Central | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | None | |||
| 9289 | 3609 | None | 35 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 5 | Drug Central | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | None | |||
| CHEMBL2336071 | 3609 | None | 35 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 5 | Drug Central | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | None | |||
| DB12371 | 3609 | None | 35 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -3 | 5 | Drug Central | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | None | |||
| 107970 | 1639 | None | 56 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -77 | 5 | Drug Central | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | None | |||
| 107970.0 | 1639 | None | 56 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -77 | 5 | Drug Central | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | None | |||
| 2407 | 1639 | None | 56 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -77 | 5 | Drug Central | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | None | |||
| 4167 | 1639 | None | 56 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -77 | 5 | Drug Central | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | None | |||
| CHEMBL314854 | 1639 | None | 56 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -77 | 5 | Drug Central | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | None | |||
| DB08868 | 1639 | None | 56 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -77 | 5 | Drug Central | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | None | |||
| 52938426 | 3376 | None | 13 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -69 | 5 | Guide to Pharmacology | 360 | 4 | 1 | 6 | 4.0 | N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N | 29608575 | |||
| 9889 | 3376 | None | 13 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -69 | 5 | Guide to Pharmacology | 360 | 4 | 1 | 6 | 4.0 | N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N | 29608575 | |||
| CHEMBL3899384 | 3376 | None | 13 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -69 | 5 | Guide to Pharmacology | 360 | 4 | 1 | 6 | 4.0 | N#Cc1cc(ccc1OC(C)C)c1onc(n1)c1cccc2c1CC[C@@H]2N | 29608575 | |||
| 44623998 | 1596 | None | 39 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -75 | 8 | Guide to Pharmacology | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 25516790 | |||
| 44623998.0 | 1596 | None | 39 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -75 | 8 | Guide to Pharmacology | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 25516790 | |||
| 9331 | 1596 | None | 39 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -75 | 8 | Guide to Pharmacology | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 25516790 | |||
| CHEMBL3358920 | 1596 | None | 39 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -75 | 8 | Guide to Pharmacology | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 25516790 | |||
| DB14766 | 1596 | None | 39 | Human | Functional | pEC50 | = | 7.6 | 7.6 | -75 | 8 | Guide to Pharmacology | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 25516790 | |||
| 46872626 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 26509640 | |||
| 46872626 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 29688337 | |||
| 9496 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 26509640 | |||
| 9496 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 29688337 | |||
| CHEMBL3741589 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 26509640 | |||
| CHEMBL3741589 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 29688337 | |||
| 52938427 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 26990079 | |||
| 52938427.0 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 26990079 | |||
| 5383 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 26990079 | |||
| 8709 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 26990079 | |||
| CHEMBL3707247 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 26990079 | |||
| DB12612 | 2984 | None | 49 | Human | Functional | pEC50 | = | 8.0 | 8.0 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | 26990079 | |||
| 44599207 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 22646698 | |||
| 44599207 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 24125884 | |||
| 44599207 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 9735753 | |||
| 44599207.0 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 22646698 | |||
| 44599207.0 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 24125884 | |||
| 44599207.0 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 9735753 | |||
| 5326 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 22646698 | |||
| 5326 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 24125884 | |||
| 5326 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 9735753 | |||
| 9289 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 22646698 | |||
| 9289 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 24125884 | |||
| 9289 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 9735753 | |||
| CHEMBL2336071 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 22646698 | |||
| CHEMBL2336071 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 24125884 | |||
| CHEMBL2336071 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 9735753 | |||
| DB12371 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 22646698 | |||
| DB12371 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 24125884 | |||
| DB12371 | 3609 | None | 35 | Human | Functional | pEC50 | = | 9.0 | 9.0 | -3 | 5 | Guide to Pharmacology | 516 | 9 | 1 | 4 | 6.8 | CCc1cc(ccc1CN1CC(C1)C(=O)O)/C(=N/OCc1ccc(c(c1)C(F)(F)F)C1CCCCC1)/C | 9735753 | |||
| 16755143 | 502 | None | 23 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 4 | Guide to Pharmacology | 442 | 4 | 1 | 5 | 5.6 | C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 | 25347187 | |||
| 9569 | 502 | None | 23 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 4 | Guide to Pharmacology | 442 | 4 | 1 | 5 | 5.6 | C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 | 25347187 | |||
| CHEMBL4297350 | 502 | None | 23 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 4 | Guide to Pharmacology | 442 | 4 | 1 | 5 | 5.6 | C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 | 25347187 | |||
| DB11819 | 502 | None | 23 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -1 | 4 | Guide to Pharmacology | 442 | 4 | 1 | 5 | 5.6 | C[C@@H](C(F)(F)F)Oc1ccc(cc1C(F)(F)F)c1onc(n1)c1ccc2c(c1)nc[nH]2 | 25347187 | |||
| 46872626 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 26509640 | |||
| 9496 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 26509640 | |||
| CHEMBL3741589 | 215 | None | 30 | Human | Functional | pEC50 | = | 8.4 | 8.4 | 74 | 2 | Guide to Pharmacology | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 26509640 | |||
| 49848557 | 1098 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -6 | 5 | Guide to Pharmacology | 461 | 7 | 1 | 8 | 4.0 | OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C | 26751273 | |||
| 9492 | 1098 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -6 | 5 | Guide to Pharmacology | 461 | 7 | 1 | 8 | 4.0 | OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C | 26751273 | |||
| CHEMBL3769933 | 1098 | None | 0 | Human | Functional | pEC50 | = | 7.8 | 7.8 | -6 | 5 | Guide to Pharmacology | 461 | 7 | 1 | 8 | 4.0 | OC(=O)CCN1CCc2c(C1)c(C)n(n2)c1nnc(s1)c1ccc(c(c1)Cl)OC(C)C | 26751273 | |||
| 11259583 | 524 | None | 19 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -380 | 7 | Guide to Pharmacology | 455 | 7 | 2 | 3 | 6.8 | OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 | 17114004 | |||
| 2925 | 524 | None | 19 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -380 | 7 | Guide to Pharmacology | 455 | 7 | 2 | 3 | 6.8 | OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 | 17114004 | |||
| CHEMBL4579553 | 524 | None | 19 | Human | Functional | pEC50 | = | 6.5 | 6.5 | -380 | 7 | Guide to Pharmacology | 455 | 7 | 2 | 3 | 6.8 | OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 | 17114004 | |||
| 11311 | 1877 | None | 39 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -3 | 2 | Guide to Pharmacology | 440 | 8 | 1 | 7 | 5.1 | OC(=O)CCCn1ccc2c1cccc2c1noc(n1)c1cnc(c(c1)Cl)OC(C)C | 27128606 | |||
| 24988201 | 1877 | None | 39 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -3 | 2 | Guide to Pharmacology | 440 | 8 | 1 | 7 | 5.1 | OC(=O)CCCn1ccc2c1cccc2c1noc(n1)c1cnc(c(c1)Cl)OC(C)C | 27128606 | |||
| CHEMBL4297542 | 1877 | None | 39 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -3 | 2 | Guide to Pharmacology | 440 | 8 | 1 | 7 | 5.1 | OC(=O)CCCn1ccc2c1cccc2c1noc(n1)c1cnc(c(c1)Cl)OC(C)C | 27128606 | |||
| DB11987 | 1877 | None | 39 | Human | Functional | pEC50 | = | 7.2 | 7.2 | -3 | 2 | Guide to Pharmacology | 440 | 8 | 1 | 7 | 5.1 | OC(=O)CCCn1ccc2c1cccc2c1noc(n1)c1cnc(c(c1)Cl)OC(C)C | 27128606 | |||
| 52938427 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| 52938427.0 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| 5383 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| 8709 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| CHEMBL3707247 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| DB12612 | 2984 | None | 49 | Human | Functional | pEC50 | = | 7.3 | 7.3 | -26 | 6 | Guide to Pharmacology | 404 | 7 | 2 | 7 | 3.6 | OCCN[C@H]1CCc2c1cccc2c1noc(n1)c1ccc(c(c1)C#N)OC(C)C | None | |||
| 10883396 | 3649 | None | 30 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -10 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11705398 | |||
| 10883396 | 3649 | None | 30 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -10 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 14732717 | |||
| 5283560 | 3649 | None | 30 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -10 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11705398 | |||
| 5283560 | 3649 | None | 30 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -10 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 14732717 | |||
| 911 | 3649 | None | 30 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -10 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11705398 | |||
| 911 | 3649 | None | 30 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -10 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 14732717 | |||
| CHEMBL225155 | 3649 | None | 30 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -10 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11705398 | |||
| CHEMBL225155 | 3649 | None | 30 | Mouse | Functional | pEC50 | = | 7.9 | 7.9 | -10 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 14732717 | |||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11705398 | |||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11967257 | |||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 14732717 | |||
| 10883396 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 17114004 | |||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11705398 | |||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11967257 | |||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 14732717 | |||
| 5283560 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 17114004 | |||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11705398 | |||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11967257 | |||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 14732717 | |||
| 911 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 17114004 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11705398 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 11967257 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 14732717 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -2 | 15 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 17114004 | |||
| 6992 | 4009 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 7 | 2 | Guide to Pharmacology | 369 | 11 | 3 | 3 | 4.3 | CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O | 21632869 | |||
| 73755254 | 4009 | None | 0 | Human | Functional | pEC50 | = | 8.6 | 8.6 | 7 | 2 | Guide to Pharmacology | 369 | 11 | 3 | 3 | 4.3 | CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O | 21632869 | |||
| 10904818 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 4 | Guide to Pharmacology | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 11967257 | |||
| 10904818 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 4 | Guide to Pharmacology | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 14732717 | |||
| 2937 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 4 | Guide to Pharmacology | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 11967257 | |||
| 2937 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 4 | Guide to Pharmacology | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 14732717 | |||
| CHEMBL382739 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 4 | Guide to Pharmacology | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 11967257 | |||
| CHEMBL382739 | 303 | None | 0 | Human | Functional | pEC50 | = | 8.9 | 8.9 | 1 | 4 | Guide to Pharmacology | 373 | 13 | 3 | 4 | 3.8 | CCCCCCCOc1ccc(cc1)CC[C@](COP(=O)(O)O)(N)C | 14732717 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 11967257 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 14747617 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 17114004 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 11967257 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 14747617 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 17114004 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 11967257 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 14747617 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 17114004 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 11967257 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 14747617 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pEC50 | = | 8.9 | 8.9 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 17114004 | |||
| 11259583 | 524 | None | 19 | Mouse | Functional | pEC50 | None | 6.5 | 6.5 | -354 | 7 | Guide to Pharmacology | 455 | 7 | 2 | 3 | 6.8 | OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 | 17114004 | |||
| 2925 | 524 | None | 19 | Mouse | Functional | pEC50 | None | 6.5 | 6.5 | -354 | 7 | Guide to Pharmacology | 455 | 7 | 2 | 3 | 6.8 | OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 | 17114004 | |||
| CHEMBL4579553 | 524 | None | 19 | Mouse | Functional | pEC50 | None | 6.5 | 6.5 | -354 | 7 | Guide to Pharmacology | 455 | 7 | 2 | 3 | 6.8 | OC(=O)CCNCc1ccc2c(c1)cc(s2)c1ccc(c(c1)C(F)(F)F)c1ccccc1 | 17114004 | |||
| 11545181 | 4015 | None | 8 | Human | Functional | pEC50 | None | 7.5 | 7.5 | -1 | 3 | Guide to Pharmacology | 370 | 12 | 4 | 3 | 3.4 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N | 17113298 | |||
| 2930 | 4015 | None | 8 | Human | Functional | pEC50 | None | 7.5 | 7.5 | -1 | 3 | Guide to Pharmacology | 370 | 12 | 4 | 3 | 3.4 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N | 17113298 | |||
| CHEMBL389033 | 4015 | None | 8 | Human | Functional | pEC50 | None | 7.5 | 7.5 | -1 | 3 | Guide to Pharmacology | 370 | 12 | 4 | 3 | 3.4 | CCCCCCCCc1cccc(c1)NC(=O)[C@@H](CCP(=O)(O)O)N | 17113298 | |||
| 12573 | 995 | None | 2 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Guide to Pharmacology | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 33738061 | |||
| 77846592 | 995 | None | 2 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Guide to Pharmacology | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 33738061 | |||
| CHEMBL4748198 | 995 | None | 2 | Human | Functional | pIC50 | = | 10 | 10.0 | - | 1 | Guide to Pharmacology | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 33738061 | |||
| 107970 | 1639 | None | 56 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -77 | 5 | Guide to Pharmacology | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 15615513 | |||
| 107970.0 | 1639 | None | 56 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -77 | 5 | Guide to Pharmacology | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 15615513 | |||
| 2407 | 1639 | None | 56 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -77 | 5 | Guide to Pharmacology | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 15615513 | |||
| 4167 | 1639 | None | 56 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -77 | 5 | Guide to Pharmacology | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 15615513 | |||
| CHEMBL314854 | 1639 | None | 56 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -77 | 5 | Guide to Pharmacology | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 15615513 | |||
| DB08868 | 1639 | None | 56 | Human | Functional | pIC50 | = | 5.7 | 5.7 | -77 | 5 | Guide to Pharmacology | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 15615513 | |||
| 2924 | 1640 | None | 38 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 14747617 | |||
| 44398069 | 1640 | None | 38 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 14747617 | |||
| 9908268 | 1640 | None | 38 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 14747617 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Functional | pIC50 | = | 9.2 | 9.2 | -4 | 7 | Guide to Pharmacology | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 14747617 | |||
| 10430549 | 1048 | None | 28 | Human | Functional | pIC50 | None | 9 | 9.0 | -1 | 4 | Guide to Pharmacology | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 16190743 | |||
| 2929 | 1048 | None | 28 | Human | Functional | pIC50 | None | 9 | 9.0 | -1 | 4 | Guide to Pharmacology | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 16190743 | |||
| CHEMBL194419 | 1048 | None | 28 | Human | Functional | pIC50 | None | 9 | 9.0 | -1 | 4 | Guide to Pharmacology | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 16190743 | |||
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name |
GPCRdb ID |
Reference ligand |
Vendors |
Species |
Assay Type |
Activity Type |
Activity Relation |
Activity Value |
p-value (-log) |
Fold selectivity |
Tested GPCRs |
Assay Description |
Source |
Mol weight |
Rot Bonds |
H don |
H acc |
LogP |
Smiles |
DOI |
|
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | |||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 9.7 | 9.7 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm100181s | |||
| 107970 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | |||
| 107970.0 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | |||
| 2407 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | |||
| 4167 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | |||
| CHEMBL314854 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | |||
| DB08868 | 1639 | None | 56 | Human | Binding | pEC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1016/j.bmcl.2013.09.058 | |||
| 49868651 | 171251 | None | 1 | Human | Binding | pEC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 542 | 8 | 2 | 8 | 5.3 | O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | |||
| CHEMBL4458575 | 171251 | None | 1 | Human | Binding | pEC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 542 | 8 | 2 | 8 | 5.3 | O=C(O)C[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | |||
| 50925337 | 170555 | None | 14 | Human | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 528 | 7 | 2 | 8 | 4.9 | O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | |||
| CHEMBL4448752 | 170555 | None | 14 | Human | Binding | pEC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 528 | 7 | 2 | 8 | 4.9 | O=C(O)[C@H]1CCCN(C[C@@H](O)c2ccc(-c3noc(-c4onc(-c5ccccc5)c4C(F)(F)F)n3)cc2)C1 | 10.1021/acs.jmedchem.6b00373 | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | |||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.8 | 8.8 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2004.07.030 | |||
| 134130131 | 142374 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1cccc(-c2cccc3cc(CNCCCC(=O)O)sc23)c1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885151 | 142374 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1cccc(-c2cccc3cc(CNCCCC(=O)O)sc23)c1 | 10.1016/j.bmcl.2016.11.050 | |||
| 46174905 | 116352 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 457 | 6 | 1 | 3 | 6.9 | O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 | 10.1021/ml500422m | |||
| CHEMBL3358955 | 116352 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 457 | 6 | 1 | 3 | 6.9 | O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 | 10.1021/ml500422m | |||
| 134129958 | 142367 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885074 | 142367 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| 44342468 | 12122 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL1184089 | 12122 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL332050 | 12122 | None | 0 | Human | Binding | pEC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| 11682677 | 11786 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1181748 | 11786 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL190865 | 11786 | None | 0 | Human | Binding | pEC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 44342231 | 12104 | None | 2 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 408 | 19 | 4 | 4 | 4.0 | CCCCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL1183950 | 12104 | None | 2 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 408 | 19 | 4 | 4 | 4.0 | CCCCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL325408 | 12104 | None | 2 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 408 | 19 | 4 | 4 | 4.0 | CCCCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| 134131071 | 142208 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | O=C(O)CCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883377 | 142208 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | O=C(O)CCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130884 | 142237 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883572 | 142237 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134131188 | 142385 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 354 | 7 | 3 | 4 | 3.6 | CCc1ccccc1-c1cccc2cc(CNCC(N)C(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885229 | 142385 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 354 | 7 | 3 | 4 | 3.6 | CCc1ccccc1-c1cccc2cc(CNCC(N)C(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 44398049 | 13183 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 441 | 13 | 5 | 5 | 3.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1190950 | 13183 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 441 | 13 | 5 | 5 | 3.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL541890 | 13183 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 441 | 13 | 5 | 5 | 3.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 44342331 | 11420 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL116953 | 11420 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL1180214 | 11420 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 428 | 16 | 4 | 4 | 4.5 | CCCCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| 44342244 | 64897 | None | 2 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL182164 | 64897 | None | 2 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL423691 | 64897 | None | 2 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 380 | 17 | 4 | 4 | 3.2 | CCCCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| 134130571 | 142304 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1cccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)c1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884292 | 142304 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1cccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)c1 | 10.1016/j.bmcl.2016.11.050 | |||
| 44398076 | 12905 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 425 | 13 | 5 | 5 | 3.2 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1188968 | 12905 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 425 | 13 | 5 | 5 | 3.2 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL537849 | 12905 | None | 0 | Human | Binding | pEC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 425 | 13 | 5 | 5 | 3.2 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 134131598 | 142357 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 373 | 4 | 1 | 3 | 5.2 | O=C(O)C1CN(Cc2cc3c(-c4ccc5ccccc5c4)cccc3s2)C1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884966 | 142357 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 373 | 4 | 1 | 3 | 5.2 | O=C(O)C1CN(Cc2cc3c(-c4ccc5ccccc5c4)cccc3s2)C1 | 10.1016/j.bmcl.2016.11.050 | |||
| 53362086 | 116419 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 481 | 7 | 1 | 4 | 6.6 | CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F | 10.1021/ml500422m | |||
| CHEMBL3359523 | 116419 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 481 | 7 | 1 | 4 | 6.6 | CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C(F)(F)F | 10.1021/ml500422m | |||
| 134131470 | 142382 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 401 | 7 | 2 | 3 | 6.4 | CCc1ccccc1-c1cccc2cc(CNc3ccc(CC(=O)O)cc3)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885195 | 142382 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 401 | 7 | 2 | 3 | 6.4 | CCc1ccccc1-c1cccc2cc(CNc3ccc(CC(=O)O)cc3)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130538 | 142248 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 351 | 5 | 1 | 3 | 4.6 | CCc1ccccc1-c1cccc2sc(CN3CC(C(=O)O)C3)cc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883646 | 142248 | None | 0 | Human | Binding | pEC50 | = | 4.7 | 4.7 | - | 0 | ChEMBL | 351 | 5 | 1 | 3 | 4.6 | CCc1ccccc1-c1cccc2sc(CN3CC(C(=O)O)C3)cc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 134131301 | 142249 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1cccc(NCc2cc3c(-c4ccc5ccccc5c4)cccc3s2)c1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883658 | 142249 | None | 0 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1cccc(NCc2cc3c(-c4ccc5ccccc5c4)cccc3s2)c1 | 10.1016/j.bmcl.2016.11.050 | |||
| 124171453 | 137413 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 473 | 6 | 0 | 7 | 4.5 | Cc1nc(CC(C)C)cc(-c2nc(-c3cc(F)c(O[C@@H]4CCC(=O)N(C)C4)cc3Cl)no2)n1 | 10.1016/j.bmcl.2015.11.090 | |||
| CHEMBL3752660 | 137413 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 473 | 6 | 0 | 7 | 4.5 | Cc1nc(CC(C)C)cc(-c2nc(-c3cc(F)c(O[C@@H]4CCC(=O)N(C)C4)cc3Cl)no2)n1 | 10.1016/j.bmcl.2015.11.090 | |||
| 134130169 | 142240 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 373 | 4 | 1 | 3 | 5.2 | O=C(O)C1CN(Cc2cc3cc(-c4ccc5ccccc5c4)ccc3s2)C1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883597 | 142240 | None | 0 | Human | Binding | pEC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 373 | 4 | 1 | 3 | 5.2 | O=C(O)C1CN(Cc2cc3cc(-c4ccc5ccccc5c4)ccc3s2)C1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130662 | 142361 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 375 | 6 | 2 | 3 | 5.5 | CC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884995 | 142361 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 375 | 6 | 2 | 3 | 5.5 | CC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| 134130114 | 142358 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | O=C(O)CCCNCc1cc2cccc(-c3cccc4ccccc34)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884986 | 142358 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | O=C(O)CCCNCc1cc2cccc(-c3cccc4ccccc34)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 44623998 | 1596 | None | 39 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | |||
| 44623998.0 | 1596 | None | 39 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | |||
| 9331 | 1596 | None | 39 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | |||
| CHEMBL3358920 | 1596 | None | 39 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | |||
| DB14766 | 1596 | None | 39 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 457 | 6 | 2 | 2 | 6.9 | OC(=O)C[C@H]1CCc2c1[nH]c1c2cc(cc1)OCc1ccc(c(c1)C(F)(F)F)C1CCCC1 | 10.1021/ml500389m | |||
| 44394564 | 12262 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 289 | 9 | 3 | 3 | 3.5 | CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL1184660 | 12262 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 289 | 9 | 3 | 3 | 3.5 | CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL363076 | 12262 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 289 | 9 | 3 | 3 | 3.5 | CCCCCCCCc1ccc2[nH]c([C@@H](N)CO)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| 134130188 | 142279 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 367 | 9 | 2 | 3 | 5.5 | CCc1ccccc1-c1cccc2cc(CNCCCCC(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884048 | 142279 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 367 | 9 | 2 | 3 | 5.5 | CCc1ccccc1-c1cccc2cc(CNCCCCC(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130519 | 142268 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 361 | 6 | 2 | 3 | 5.3 | O=C(O)CCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883972 | 142268 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 361 | 6 | 2 | 3 | 5.3 | O=C(O)CCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130022 | 142297 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 339 | 7 | 2 | 3 | 4.7 | CCc1ccccc1-c1cccc2cc(CNCCC(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884172 | 142297 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 339 | 7 | 2 | 3 | 4.7 | CCc1ccccc1-c1cccc2cc(CNCCC(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 11675907 | 11780 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 409 | 12 | 4 | 4 | 4.3 | CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1181694 | 11780 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 409 | 12 | 4 | 4 | 4.3 | CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL188881 | 11780 | None | 0 | Human | Binding | pEC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 409 | 12 | 4 | 4 | 4.3 | CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 134130111 | 142390 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 347 | 5 | 2 | 3 | 4.9 | O=C(O)CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885275 | 142390 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 347 | 5 | 2 | 3 | 4.9 | O=C(O)CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134131081 | 142225 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 361 | 6 | 2 | 3 | 5.3 | O=C(O)CCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883456 | 142225 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 361 | 6 | 2 | 3 | 5.3 | O=C(O)CCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130375 | 142289 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884099 | 142289 | None | 0 | Human | Binding | pEC50 | = | 5.6 | 5.6 | - | 0 | ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| 44398170 | 11776 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 411 | 12 | 4 | 4 | 4.2 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1181688 | 11776 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 411 | 12 | 4 | 4 | 4.2 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL188826 | 11776 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 411 | 12 | 4 | 4 | 4.2 | CCCCCCCCc1ccc(-c2c[nH]c([C@@H](N)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 134130732 | 142281 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 393 | 7 | 2 | 3 | 5.5 | O=C(O)CCCNCc1cc2cccc(-c3cccc(C(F)(F)F)c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884056 | 142281 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 393 | 7 | 2 | 3 | 5.5 | O=C(O)CCCNCc1cc2cccc(-c3cccc(C(F)(F)F)c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130546 | 142256 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 361 | 6 | 2 | 3 | 5.3 | O=C(O)CCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883812 | 142256 | None | 0 | Human | Binding | pEC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 361 | 6 | 2 | 3 | 5.3 | O=C(O)CCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134131256 | 142264 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 369 | 7 | 2 | 5 | 4.3 | O=C(O)CCCNCc1cc2cccc(-c3ccc4c(c3)OCO4)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883947 | 142264 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 369 | 7 | 2 | 5 | 4.3 | O=C(O)CCCNCc1cc2cccc(-c3ccc4c(c3)OCO4)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130150 | 142226 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883471 | 142226 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| 124171444 | 137497 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 435 | 7 | 1 | 7 | 4.0 | Cc1cc(-c2nc(-c3cc(C)c(OC[C@@H]4CCC(=O)N4)c(C)n3)no2)cc(CC(C)C)n1 | 10.1016/j.bmcl.2015.11.090 | |||
| CHEMBL3753300 | 137497 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 435 | 7 | 1 | 7 | 4.0 | Cc1cc(-c2nc(-c3cc(C)c(OC[C@@H]4CCC(=O)N4)c(C)n3)no2)cc(CC(C)C)n1 | 10.1016/j.bmcl.2015.11.090 | |||
| 124171442 | 137536 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 422 | 6 | 2 | 8 | 3.3 | Cc1cc(-c2nc(-c3ccc(O[C@H]4CCC(=O)NC4)c(C)n3)no2)cc(NC(C)C)n1 | 10.1016/j.bmcl.2015.11.090 | |||
| CHEMBL3753609 | 137536 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 422 | 6 | 2 | 8 | 3.3 | Cc1cc(-c2nc(-c3ccc(O[C@H]4CCC(=O)NC4)c(C)n3)no2)cc(NC(C)C)n1 | 10.1016/j.bmcl.2015.11.090 | |||
| 134130316 | 142409 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 347 | 5 | 2 | 3 | 4.9 | O=C(O)CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885468 | 142409 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 347 | 5 | 2 | 3 | 4.9 | O=C(O)CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134131399 | 142402 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1ccccc1-c1cccc2cc(CNCCCC(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885401 | 142402 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 339 | 7 | 2 | 3 | 4.8 | Cc1ccccc1-c1cccc2cc(CNCCCC(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130548 | 142276 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 6.7 | O=C(O)c1ccc(CNCc2cc3c(-c4ccc5ccccc5c4)cccc3s2)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884011 | 142276 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 6.7 | O=C(O)c1ccc(CNCc2cc3c(-c4ccc5ccccc5c4)cccc3s2)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| 124171447 | 137518 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 425 | 6 | 1 | 7 | 3.5 | Cc1nc(CC(C)C)cc(-c2nc(-c3ccc(O[C@@H]4CCC(=O)NC4)c(F)c3)no2)n1 | 10.1016/j.bmcl.2015.11.090 | |||
| CHEMBL3753479 | 137518 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 425 | 6 | 1 | 7 | 3.5 | Cc1nc(CC(C)C)cc(-c2nc(-c3ccc(O[C@@H]4CCC(=O)NC4)c(F)c3)no2)n1 | 10.1016/j.bmcl.2015.11.090 | |||
| 44398058 | 11770 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1181660 | 11770 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL187712 | 11770 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 395 | 12 | 4 | 4 | 4.1 | CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 124221654 | 1123 | None | 1 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 | 10.1016/j.bmcl.2016.11.050 | |||
| 9495 | 1123 | None | 1 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884038 | 1123 | None | 1 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | OC(=O)CCCNCc1cc2c(s1)c(ccc2)c1ccc2c(c1)cccc2 | 10.1016/j.bmcl.2016.11.050 | |||
| 44394289 | 12413 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 383 | 11 | 4 | 4 | 3.7 | CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL1185803 | 12413 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 383 | 11 | 4 | 4 | 3.7 | CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL433593 | 12413 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 383 | 11 | 4 | 4 | 3.7 | CCCCCCCCc1ccc2[nH]c(C(C)(N)COP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| 44394521 | 11765 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 289 | 9 | 3 | 3 | 3.5 | CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL1181640 | 11765 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 289 | 9 | 3 | 3 | 3.5 | CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL186815 | 11765 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 289 | 9 | 3 | 3 | 3.5 | CCCCCCCCc1ccc2[nH]c([C@H](N)CO)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| 134131209 | 142405 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 401 | 7 | 2 | 3 | 6.4 | CCc1ccccc1-c1cccc2cc(CNc3cccc(CC(=O)O)c3)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885415 | 142405 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 401 | 7 | 2 | 3 | 6.4 | CCc1ccccc1-c1cccc2cc(CNc3cccc(CC(=O)O)c3)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 2924 | 1640 | None | 38 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2005.05.097 | |||
| 44398069 | 1640 | None | 38 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2005.05.097 | |||
| 9908268 | 1640 | None | 38 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1016/j.bmcl.2005.05.097 | |||
| 134131067 | 142272 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1ccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883991 | 142272 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1ccc(NCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| 10023913 | 12137 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 400 | 14 | 4 | 4 | 3.7 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL1184130 | 12137 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 400 | 14 | 4 | 4 | 3.7 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL334038 | 12137 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 400 | 14 | 4 | 4 | 3.7 | CCCCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| 67249162 | 116416 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 404 | 7 | 1 | 5 | 4.8 | CC(C)Oc1ccc(COc2ccc3c(c2)cc2n3CCC2CC(=O)O)cc1C#N | 10.1021/ml500422m | |||
| CHEMBL3359520 | 116416 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 404 | 7 | 1 | 5 | 4.8 | CC(C)Oc1ccc(COc2ccc3c(c2)cc2n3CCC2CC(=O)O)cc1C#N | 10.1021/ml500422m | |||
| 134129983 | 142235 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883555 | 142235 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130146 | 142212 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 353 | 7 | 2 | 3 | 4.9 | CCc1ccccc1-c1cccc2cc(CNCC(C)C(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883401 | 142212 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 353 | 7 | 2 | 3 | 4.9 | CCc1ccccc1-c1cccc2cc(CNCC(C)C(=O)O)sc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 44342219 | 11415 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL115344 | 11415 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL1180152 | 11415 | None | 0 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | |||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 7.4 | 7.4 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | |||
| 134130183 | 142255 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 6.7 | O=C(O)c1ccc(CNCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883805 | 142255 | None | 0 | Human | Binding | pEC50 | = | 5.4 | 5.4 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 6.7 | O=C(O)c1ccc(CNCc2cc3cccc(-c4ccc5ccccc5c4)c3s2)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134131169 | 142350 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 381 | 7 | 2 | 3 | 5.8 | CC(C)(C)c1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884888 | 142350 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 381 | 7 | 2 | 3 | 5.8 | CC(C)(C)c1ccc(-c2cccc3cc(CNCCCC(=O)O)sc23)cc1 | 10.1016/j.bmcl.2016.11.050 | |||
| 67250226 | 116418 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 438 | 7 | 1 | 5 | 5.5 | CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C#N | 10.1021/ml500422m | |||
| CHEMBL3359522 | 116418 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 438 | 7 | 1 | 5 | 5.5 | CC(C)Oc1ccc(COc2ccc3c(c2)c(Cl)c2n3CC[C@@H]2CC(=O)O)cc1C#N | 10.1021/ml500422m | |||
| 134131475 | 142274 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 401 | 7 | 2 | 3 | 6.4 | CCc1ccccc1-c1cccc2sc(CNc3ccc(CC(=O)O)cc3)cc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883998 | 142274 | None | 0 | Human | Binding | pEC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 401 | 7 | 2 | 3 | 6.4 | CCc1ccccc1-c1cccc2sc(CNc3ccc(CC(=O)O)cc3)cc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130066 | 142340 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 401 | 8 | 2 | 3 | 6.2 | O=C(O)CCCNCc1cc2cccc(-c3cccc(-c4ccccc4)c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884809 | 142340 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 401 | 8 | 2 | 3 | 6.2 | O=C(O)CCCNCc1cc2cccc(-c3cccc(-c4ccccc4)c3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 49839234 | 118015 | None | 0 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 472 | 6 | 3 | 3 | 6.1 | O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 | 10.1016/j.bmcl.2014.11.089 | |||
| CHEMBL3403619 | 118015 | None | 0 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 472 | 6 | 3 | 3 | 6.1 | O=C(O)CC1NCCc2c1[nH]c1ccc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)cc21 | 10.1016/j.bmcl.2014.11.089 | |||
| 134131291 | 142238 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 373 | 4 | 1 | 3 | 5.2 | O=C(O)C1CN(Cc2cc3cccc(-c4ccc5ccccc5c4)c3s2)C1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883579 | 142238 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 373 | 4 | 1 | 3 | 5.2 | O=C(O)C1CN(Cc2cc3cccc(-c4ccc5ccccc5c4)c3s2)C1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130695 | 142223 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 347 | 5 | 2 | 3 | 4.9 | O=C(O)CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883447 | 142223 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 347 | 5 | 2 | 3 | 4.9 | O=C(O)CNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 44398012 | 12268 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 425 | 12 | 4 | 4 | 4.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1184707 | 12268 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 425 | 12 | 4 | 4 | 4.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL364950 | 12268 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 425 | 12 | 4 | 4 | 4.4 | CCCCCCCCc1ccc(-c2c[nH]c(C(C)(N)COP(O)(O)=S)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 44342175 | 85554 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 2 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL227371 | 85554 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 2 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL422074 | 85554 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 2 | ChEMBL | 372 | 12 | 4 | 4 | 3.0 | CCCCCCCCc1ccc(NC(=O)[C@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| 44342339 | 11410 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL114031 | 11410 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL1180115 | 11410 | None | 0 | Human | Binding | pEC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 344 | 10 | 4 | 4 | 2.2 | CCCCCCc1ccc(NC(=O)[C@@H](N)COP(=O)(O)O)cc1 | 10.1016/s0960-894x(03)00812-6 | |||
| 134131363 | 142337 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 393 | 7 | 2 | 3 | 5.5 | O=C(O)CCCNCc1cc2cccc(-c3ccc(C(F)(F)F)cc3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884795 | 142337 | None | 0 | Human | Binding | pEC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 393 | 7 | 2 | 3 | 5.5 | O=C(O)CCCNCc1cc2cccc(-c3ccc(C(F)(F)F)cc3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 44394497 | 66715 | None | 0 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 497 | 11 | 4 | 6 | 4.3 | CCCCCCCCc1ccc2[nH]c([C@@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL185491 | 66715 | None | 0 | Human | Binding | pEC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 497 | 11 | 4 | 6 | 4.3 | CCCCCCCCc1ccc2[nH]c([C@@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F | 10.1016/j.bmcl.2004.07.030 | |||
| 134131381 | 142396 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | O=C(O)CCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885331 | 142396 | None | 0 | Human | Binding | pEC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 375 | 7 | 2 | 3 | 5.7 | O=C(O)CCCNCc1cc2c(-c3ccc4ccccc4c3)cccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 44342221 | 12097 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 352 | 15 | 4 | 4 | 2.5 | CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL1183918 | 12097 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 352 | 15 | 4 | 4 | 2.5 | CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL324358 | 12097 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 352 | 15 | 4 | 4 | 2.5 | CCCCCCCCCCCCNC(=O)[C@@H](N)COP(=O)(O)O | 10.1016/s0960-894x(03)00812-6 | |||
| 134130947 | 142316 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 401 | 8 | 2 | 3 | 6.2 | O=C(O)CCCNCc1cc2cccc(-c3ccc(-c4ccccc4)cc3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884580 | 142316 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 401 | 8 | 2 | 3 | 6.2 | O=C(O)CCCNCc1cc2cccc(-c3ccc(-c4ccccc4)cc3)c2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134131043 | 142365 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 401 | 7 | 2 | 3 | 6.1 | CCc1ccccc1-c1cccc2sc(CNCc3ccc(C(=O)O)cc3)cc12 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3885068 | 142365 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 401 | 7 | 2 | 3 | 6.1 | CCc1ccccc1-c1cccc2sc(CNCc3ccc(C(=O)O)cc3)cc12 | 10.1016/j.bmcl.2016.11.050 | |||
| 44398074 | 12891 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 345 | 11 | 4 | 4 | 3.1 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1188885 | 12891 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 345 | 11 | 4 | 4 | 3.1 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL537632 | 12891 | None | 0 | Human | Binding | pEC50 | = | 5.2 | 5.2 | - | 0 | ChEMBL | 345 | 11 | 4 | 4 | 3.1 | CCCCCCCCc1ccc(-c2c[nH]c(C(N)(CO)CO)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 134131297 | 142244 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3883621 | 142244 | None | 0 | Human | Binding | pEC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 389 | 8 | 2 | 3 | 6.1 | O=C(O)CCCCNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1 | 10.1016/j.bmcl.2016.11.050 | |||
| 134130023 | 142298 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884173 | 142298 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 376 | 6 | 3 | 4 | 4.2 | NC(CNCc1cc2cc(-c3ccc4ccccc4c3)ccc2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| 66829311 | 139896 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 530 | 13 | 3 | 9 | 3.6 | CCc1cc(-c2noc(-c3cc(C)c(CN(C)CC(C)C)s3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1016/j.ejmech.2016.03.048 | |||
| CHEMBL3798837 | 139896 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 530 | 13 | 3 | 9 | 3.6 | CCc1cc(-c2noc(-c3cc(C)c(CN(C)CC(C)C)s3)n2)cc(C)c1OC[C@@H](O)CNC(=O)CO | 10.1016/j.ejmech.2016.03.048 | |||
| 134131316 | 142286 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1cccc(NCc2cc3cc(-c4ccc5ccccc5c4)ccc3s2)c1 | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884077 | 142286 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 423 | 6 | 2 | 3 | 7.0 | O=C(O)Cc1cccc(NCc2cc3cc(-c4ccc5ccccc5c4)ccc3s2)c1 | 10.1016/j.bmcl.2016.11.050 | |||
| 44394327 | 11756 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 383 | 11 | 4 | 4 | 4.0 | CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL1181601 | 11756 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 383 | 11 | 4 | 4 | 4.0 | CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL183894 | 11756 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 383 | 11 | 4 | 4 | 4.0 | CCCCCCCCc1ccc2[nH]c([C@@H](N)[C@@H](C)OP(=O)(O)O)nc2c1 | 10.1016/j.bmcl.2004.07.030 | |||
| 44394459 | 123704 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 497 | 11 | 4 | 6 | 4.3 | CCCCCCCCc1ccc2[nH]c([C@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F | 10.1016/j.bmcl.2004.07.030 | |||
| CHEMBL361915 | 123704 | None | 0 | Human | Binding | pEC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 497 | 11 | 4 | 6 | 4.3 | CCCCCCCCc1ccc2[nH]c([C@H](N)COP(=O)(O)O)nc2c1.COC(=O)C(F)(F)F | 10.1016/j.bmcl.2004.07.030 | |||
| 46174905 | 116352 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 457 | 6 | 1 | 3 | 6.9 | O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 | 10.1021/ml500422m | |||
| CHEMBL3358955 | 116352 | None | 0 | Human | Binding | pEC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 457 | 6 | 1 | 3 | 6.9 | O=C(O)CC1CCn2c1cc1cc(OCc3ccc(C4CCCC4)c(C(F)(F)F)c3)ccc12 | 10.1021/ml500422m | |||
| 44398172 | 11783 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 315 | 10 | 3 | 3 | 4.0 | CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL1181739 | 11783 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 315 | 10 | 3 | 3 | 4.0 | CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL190529 | 11783 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 315 | 10 | 3 | 3 | 4.0 | CCCCCCCCc1ccc(-c2c[nH]c([C@H](N)CO)n2)cc1 | 10.1016/j.bmcl.2005.05.097 | |||
| 134130192 | 142291 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 375 | 6 | 2 | 3 | 5.5 | CC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| CHEMBL3884134 | 142291 | None | 0 | Human | Binding | pEC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 375 | 6 | 2 | 3 | 5.5 | CC(CNCc1cc2cccc(-c3ccc4ccccc4c3)c2s1)C(=O)O | 10.1016/j.bmcl.2016.11.050 | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2005.05.097 | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2005.05.097 | |||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2005.05.097 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2005.05.097 | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | |||
| 911 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pEC50 | = | 8.0 | 8.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/s0960-894x(03)00812-6 | |||
| 67249162 | 116416 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 404 | 7 | 1 | 5 | 4.8 | CC(C)Oc1ccc(COc2ccc3c(c2)cc2n3CCC2CC(=O)O)cc1C#N | 10.1021/ml500422m | |||
| CHEMBL3359520 | 116416 | None | 0 | Human | Binding | pEC50 | = | 5.0 | 5.0 | - | 0 | ChEMBL | 404 | 7 | 1 | 5 | 4.8 | CC(C)Oc1ccc(COc2ccc3c(c2)cc2n3CCC2CC(=O)O)cc1C#N | 10.1021/ml500422m | |||
| 11743459 | 140878 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 431 | 7 | 1 | 5 | 4.4 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| CHEMBL381872 | 140878 | None | 0 | Human | Binding | pIC50 | = | 9.5 | 9.5 | - | 0 | ChEMBL | 431 | 7 | 1 | 5 | 4.4 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| 11575787 | 70656 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 439 | 6 | 1 | 5 | 4.8 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| CHEMBL195014 | 70656 | None | 0 | Human | Binding | pIC50 | = | 9.4 | 9.4 | - | 0 | ChEMBL | 439 | 6 | 1 | 5 | 4.8 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| 11604577 | 72349 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 439 | 6 | 1 | 5 | 4.8 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| CHEMBL198415 | 72349 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 439 | 6 | 1 | 5 | 4.8 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| 10408874 | 72515 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 403 | 6 | 1 | 5 | 4.6 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| CHEMBL198976 | 72515 | None | 0 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 0 | ChEMBL | 403 | 6 | 1 | 5 | 4.6 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm0492507 | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm0492507 | |||
| 911 | 3649 | None | 30 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm0492507 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pIC50 | = | 9.3 | 9.3 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1021/jm0492507 | |||
| 44394191 | 66330 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 381 | 12 | 3 | 2 | 5.3 | CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL184879 | 66330 | None | 0 | Human | Binding | pIC50 | = | 9.2 | 9.2 | - | 0 | ChEMBL | 381 | 12 | 3 | 2 | 5.3 | CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| 44394191 | 66330 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 381 | 12 | 3 | 2 | 5.3 | CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL184879 | 66330 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 381 | 12 | 3 | 2 | 5.3 | CCCCCCCCCc1ccc(C2CCC(CCP(=O)(O)O)N2)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| 2924 | 1640 | None | 38 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm0492507 | |||
| 44398069 | 1640 | None | 38 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm0492507 | |||
| 9908268 | 1640 | None | 38 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm0492507 | |||
| CHEMBL114606 | 1640 | None | 38 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 387 | 14 | 4 | 4 | 3.3 | CCCCCCCCc1ccc(cc1)CCC(COP(=O)(O)O)(CO)N | 10.1021/jm0492507 | |||
| 46905530 | 10294 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 389 | 14 | 5 | 6 | 2.6 | CCCCCCCCc1ccc(CCC(N)(CO)CO[PH](O)(O)O)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL1161691 | 10294 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 389 | 14 | 5 | 6 | 2.6 | CCCCCCCCc1ccc(CCC(N)(CO)CO[PH](O)(O)O)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| 9979368 | 71730 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 417 | 6 | 1 | 5 | 5.0 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| CHEMBL196534 | 71730 | None | 0 | Human | Binding | pIC50 | = | 9.1 | 9.1 | - | 0 | ChEMBL | 417 | 6 | 1 | 5 | 5.0 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| 10430549 | 1048 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 10.1021/jm0503244 | |||
| 2929 | 1048 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 10.1021/jm0503244 | |||
| CHEMBL194419 | 1048 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 10.1021/jm0503244 | |||
| 10045980 | 69862 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 391 | 8 | 1 | 5 | 4.3 | CCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL193789 | 69862 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 391 | 8 | 1 | 5 | 4.3 | CCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| 49830722 | 71778 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 6 | 1 | 3 | 4.1 | Cc1cc(OCc2cccc(C(F)(F)F)c2)ccc1CN1CC(C(=O)O)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL1966501 | 71778 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 6 | 1 | 3 | 4.1 | Cc1cc(OCc2cccc(C(F)(F)F)c2)ccc1CN1CC(C(=O)O)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 49830919 | 72015 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 6 | 1 | 2 | 4.0 | O=C(O)C1CN(Cc2ccc(CCc3cccc(C(F)(F)F)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL1973936 | 72015 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 363 | 6 | 1 | 2 | 4.0 | O=C(O)C1CN(Cc2ccc(CCc3cccc(C(F)(F)F)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 46872619 | 72527 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 6 | 1 | 3 | 4.4 | Cc1cc(OCc2ccc(Cl)c(Cl)c2)ccc1CN1CC(C(=O)O)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL1990223 | 72527 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 379 | 6 | 1 | 3 | 4.4 | Cc1cc(OCc2ccc(Cl)c(Cl)c2)ccc1CN1CC(C(=O)O)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 127037695 | 136662 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 333 | 12 | 1 | 3 | 4.3 | CCCCCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739440 | 136662 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 333 | 12 | 1 | 3 | 4.3 | CCCCCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451793 | 136849 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 399 | 6 | 1 | 3 | 4.5 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)c(Cl)c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741092 | 136849 | None | 0 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 399 | 6 | 1 | 3 | 4.5 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)c(Cl)c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10430549 | 1048 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 10.1016/j.bmcl.2006.03.090 | |||
| 2929 | 1048 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL194419 | 1048 | None | 28 | Human | Binding | pIC50 | = | 9 | 9.0 | - | 0 | ChEMBL | 391 | 7 | 1 | 5 | 4.1 | CC(Cc1ccc(cc1)c1onc(n1)c1ccc(cc1)CN1CC(C1)C(=O)O)C | 10.1016/j.bmcl.2006.03.090 | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2008.11.072 | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2008.11.072 | |||
| 911 | 3649 | None | 30 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2008.11.072 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2008.11.072 | |||
| 44591266 | 179406 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 443 | 13 | 4 | 5 | 4.2 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F | 10.1016/j.bmcl.2008.11.072 | |||
| CHEMBL473269 | 179406 | None | 0 | Human | Binding | pIC50 | = | 9.0 | 9.0 | - | 0 | ChEMBL | 443 | 13 | 4 | 5 | 4.2 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1F | 10.1016/j.bmcl.2008.11.072 | |||
| 44394273 | 64599 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 395 | 12 | 3 | 2 | 5.6 | CCCCCCCCCc1ccc(CN[C@H]2CCC[C@H](P(=O)(O)O)C2)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL181597 | 64599 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 395 | 12 | 3 | 2 | 5.6 | CCCCCCCCCc1ccc(CN[C@H]2CCC[C@H](P(=O)(O)O)C2)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| 44591265 | 180087 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 425 | 13 | 4 | 5 | 4.1 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2008.11.072 | |||
| CHEMBL474689 | 180087 | None | 0 | Human | Binding | pIC50 | = | 8.9 | 8.9 | - | 0 | ChEMBL | 425 | 13 | 4 | 5 | 4.1 | CCCCCCCCOc1ccc(-c2c[nH]c([C@@](C)(N)COP(=O)(O)O)n2)cc1 | 10.1016/j.bmcl.2008.11.072 | |||
| 10317453 | 70442 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 377 | 7 | 1 | 5 | 3.9 | CCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL194578 | 70442 | None | 0 | Human | Binding | pIC50 | = | 8.8 | 8.8 | - | 0 | ChEMBL | 377 | 7 | 1 | 5 | 3.9 | CCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| 10363915 | 135262 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 405 | 7 | 1 | 5 | 4.6 | CCC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL372066 | 135262 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 405 | 7 | 1 | 5 | 4.6 | CCC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| 59451812 | 136976 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 331 | 6 | 1 | 3 | 3.4 | O=C(O)C1CN(Cc2ccc(OCc3cccc(Cl)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3742245 | 136976 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 331 | 6 | 1 | 3 | 3.4 | O=C(O)C1CN(Cc2ccc(OCc3cccc(Cl)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451770 | 136986 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 277 | 8 | 1 | 3 | 2.8 | CCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3742304 | 136986 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 277 | 8 | 1 | 3 | 2.8 | CCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10127776 | 11057 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 465 | 15 | 3 | 4 | 4.9 | CCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC | 10.1021/jm0492507 | |||
| CHEMBL117723 | 11057 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 465 | 15 | 3 | 4 | 4.9 | CCCCCCCCOc1c(Br)cc(CNCCCP(=O)(O)O)cc1OC | 10.1021/jm0492507 | |||
| 11271470 | 137671 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 475 | 8 | 1 | 4 | 6.1 | CCc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 | 10.1021/jm0492507 | |||
| CHEMBL375488 | 137671 | None | 0 | Human | Binding | pIC50 | = | 8 | 8.0 | - | 0 | ChEMBL | 475 | 8 | 1 | 4 | 6.1 | CCc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 | 10.1021/jm0492507 | |||
| 44412282 | 78327 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 405 | 7 | 2 | 5 | 4.9 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL210785 | 78327 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 405 | 7 | 2 | 5 | 4.9 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| 11502026 | 71478 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 391 | 5 | 1 | 5 | 4.2 | CC(C)(C)c1ccc(-c2nnc(-c3ccc(CN4CC(C(=O)O)C4)cc3)o2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL196149 | 71478 | None | 0 | Human | Binding | pIC50 | = | 6 | 6.0 | - | 0 | ChEMBL | 391 | 5 | 1 | 5 | 4.2 | CC(C)(C)c1ccc(-c2nnc(-c3ccc(CN4CC(C(=O)O)C4)cc3)o2)cc1 | 10.1021/jm0503244 | |||
| 11683935 | 179447 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 456 | 9 | 4 | 5 | 3.7 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL473563 | 179447 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 456 | 9 | 4 | 5 | 3.7 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| 59451878 | 136782 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 311 | 6 | 1 | 3 | 3.3 | C[C@@H](Oc1ccc(CN2CC(C(=O)O)C2)cc1)c1ccccc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740494 | 136782 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 311 | 6 | 1 | 3 | 3.3 | C[C@@H](Oc1ccc(CN2CC(C(=O)O)C2)cc1)c1ccccc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10251062 | 70661 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 411 | 6 | 1 | 5 | 4.6 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(-c5ccccc5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| CHEMBL195025 | 70661 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 411 | 6 | 1 | 5 | 4.6 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(-c5ccccc5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| 44413349 | 77668 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.4 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL208838 | 77668 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.4 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 10149721 | 85131 | None | 4 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 317 | 11 | 1 | 2 | 4.5 | CCCCCCCCCc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/jm0492507 | |||
| CHEMBL224623 | 85131 | None | 4 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 317 | 11 | 1 | 2 | 4.5 | CCCCCCCCCc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/jm0492507 | |||
| 44394220 | 67024 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 375 | 15 | 3 | 2 | 5.8 | CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL186921 | 67024 | None | 0 | Human | Binding | pIC50 | = | 7.0 | 7.0 | - | 0 | ChEMBL | 375 | 15 | 3 | 2 | 5.8 | CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 | 10.1016/j.bmcl.2004.07.049 | |||
| 59451743 | 136864 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 361 | 7 | 1 | 4 | 3.4 | COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1ccccc1Cl | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741222 | 136864 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 361 | 7 | 1 | 4 | 3.4 | COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1ccccc1Cl | 10.1021/acs.jmedchem.5b00928 | |||
| 10249979 | 71670 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 393 | 7 | 1 | 6 | 3.7 | CC(C)Oc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL196357 | 71670 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 393 | 7 | 1 | 6 | 3.7 | CC(C)Oc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| 11603220 | 135250 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 375 | 6 | 1 | 5 | 3.8 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CC5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| CHEMBL371985 | 135250 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 375 | 6 | 1 | 5 | 3.8 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CC5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| 11408903 | 85160 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 475 | 7 | 1 | 4 | 6.1 | Cc1cc(CN2CC(C(=O)O)C2)cc(C)c1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 | 10.1021/jm0492507 | |||
| CHEMBL224853 | 85160 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 475 | 7 | 1 | 4 | 6.1 | Cc1cc(CN2CC(C(=O)O)C2)cc(C)c1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 | 10.1021/jm0492507 | |||
| 44565738 | 189862 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 445 | 11 | 4 | 5 | 3.8 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCc3ccccc3)cc2)c[nH]1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL515917 | 189862 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 445 | 11 | 4 | 5 | 3.8 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCc3ccccc3)cc2)c[nH]1 | 10.1016/j.bmcl.2009.02.073 | |||
| 10195325 | 85154 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)C1CCN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1021/jm0492507 | |||
| CHEMBL224799 | 85154 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 461 | 7 | 1 | 4 | 5.9 | O=C(O)C1CCN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1021/jm0492507 | |||
| 46872748 | 136962 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 319 | 9 | 1 | 3 | 3.9 | CCCCCCOc1ccc(CN2CCC[C@H](C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3742107 | 136962 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 319 | 9 | 1 | 3 | 3.9 | CCCCCCOc1ccc(CN2CCC[C@H](C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 11540052 | 180673 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 470 | 10 | 4 | 5 | 3.7 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL475405 | 180673 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 470 | 10 | 4 | 5 | 3.7 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| 59451751 | 136808 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 319 | 9 | 1 | 3 | 3.9 | CCCCCCOc1ccc(CN2CCC[C@@H](C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740739 | 136808 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 319 | 9 | 1 | 3 | 3.9 | CCCCCCOc1ccc(CN2CCC[C@@H](C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 44412221 | 77139 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 391 | 6 | 2 | 5 | 4.5 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL207580 | 77139 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 391 | 6 | 2 | 5 | 4.5 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| 44412165 | 77790 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL209076 | 77790 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| 10288527 | 85063 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 461 | 7 | 1 | 4 | 5.8 | Cc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 | 10.1021/jm0492507 | |||
| CHEMBL224005 | 85063 | None | 0 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 461 | 7 | 1 | 4 | 5.8 | Cc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 | 10.1021/jm0492507 | |||
| 44344193 | 114976 | None | 4 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 335 | 17 | 3 | 2 | 4.8 | CCCCCCCCCCCCCCNCCCP(=O)(O)O | 10.1021/jm0492507 | |||
| CHEMBL334213 | 114976 | None | 4 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 335 | 17 | 3 | 2 | 4.8 | CCCCCCCCCCCCCCNCCCP(=O)(O)O | 10.1021/jm0492507 | |||
| 44344193 | 114976 | None | 4 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 335 | 17 | 3 | 2 | 4.8 | CCCCCCCCCCCCCCNCCCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL334213 | 114976 | None | 4 | Human | Binding | pIC50 | = | 7.9 | 7.9 | - | 0 | ChEMBL | 335 | 17 | 3 | 2 | 4.8 | CCCCCCCCCCCCCCNCCCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| 44413274 | 138798 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 447 | 6 | 2 | 4 | 5.7 | O=C(O)C1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL377968 | 138798 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 447 | 6 | 2 | 4 | 5.7 | O=C(O)C1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 44394220 | 67024 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 375 | 15 | 3 | 2 | 5.8 | CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL186921 | 67024 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 375 | 15 | 3 | 2 | 5.8 | CCCCCCCCCCCCCCNC1CCCC(P(=O)(O)O)C1 | 10.1016/j.bmcl.2004.07.049 | |||
| 11503967 | 8023 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 482 | 10 | 4 | 5 | 3.9 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2010.02.098 | |||
| CHEMBL1090796 | 8023 | None | 0 | Human | Binding | pIC50 | = | 5.9 | 5.9 | - | 0 | ChEMBL | 482 | 10 | 4 | 5 | 3.9 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(C(=O)CCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2010.02.098 | |||
| 44413430 | 138856 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 405 | 7 | 2 | 5 | 4.7 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@@H](CC(=O)O)CN4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL378061 | 138856 | None | 0 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 405 | 7 | 2 | 5 | 4.7 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@@H](CC(=O)O)CN4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.090 | |||
| 4492589 | 30916 | None | 3 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 359 | 3 | 1 | 2 | 6.1 | Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | 10.1016/j.bmcl.2011.04.097 | |||
| CHEMBL1397874 | 30916 | None | 3 | Human | Binding | pIC50 | = | 4.9 | 4.9 | - | 0 | ChEMBL | 359 | 3 | 1 | 2 | 6.1 | Cc1cccc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | 10.1016/j.bmcl.2011.04.097 | |||
| 11224984 | 8719 | None | 24 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 460 | 8 | 2 | 6 | 4.3 | CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C | 10.1021/jm100181s | |||
| CHEMBL1095833 | 8719 | None | 24 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | ChEMBL | 460 | 8 | 2 | 6 | 4.3 | CCC/N=C1\S/C(=C\c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C | 10.1021/jm100181s | |||
| 59451867 | 136876 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 335 | 4 | 1 | 2 | 4.2 | O=C(O)C1CN(Cc2ccc(-c3cc(Cl)cc(Cl)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741338 | 136876 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 335 | 4 | 1 | 2 | 4.2 | O=C(O)C1CN(Cc2ccc(-c3cc(Cl)cc(Cl)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 44412165 | 77790 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL209076 | 77790 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| 44394212 | 67191 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 373 | 15 | 2 | 2 | 6.5 | CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL187692 | 67191 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 373 | 15 | 2 | 2 | 6.5 | CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 | 10.1016/j.bmcl.2004.07.049 | |||
| 44412364 | 78132 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL210257 | 78132 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| 46872874 | 136702 | None | 1 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 319 | 9 | 1 | 3 | 3.9 | CCCCCCOc1ccc(CN2CCC(C(=O)O)CC2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739759 | 136702 | None | 1 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 319 | 9 | 1 | 3 | 3.9 | CCCCCCOc1ccc(CN2CCC(C(=O)O)CC2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451883 | 136922 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 295 | 6 | 1 | 2 | 3.0 | O=C(O)C1CN(Cc2ccc(CCc3ccccc3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741743 | 136922 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 295 | 6 | 1 | 2 | 3.0 | O=C(O)C1CN(Cc2ccc(CCc3ccccc3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10174255 | 85251 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 485 | 6 | 1 | 6 | 5.7 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)cc2)C1 | 10.1021/jm0492507 | |||
| CHEMBL225575 | 85251 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 485 | 6 | 1 | 6 | 5.7 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4cc(-c5ccccc5)c(C(F)(F)F)s4)n3)cc2)C1 | 10.1021/jm0492507 | |||
| 44394279 | 67171 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 375 | 16 | 3 | 2 | 5.8 | CCCCCCCCCCCCCC[C@H]1CC[C@H](CCP(=O)(O)O)N1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL187588 | 67171 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 375 | 16 | 3 | 2 | 5.8 | CCCCCCCCCCCCCC[C@H]1CC[C@H](CCP(=O)(O)O)N1 | 10.1016/j.bmcl.2004.07.049 | |||
| 10217498 | 85120 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 481 | 7 | 1 | 4 | 6.2 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 | 10.1021/jm0492507 | |||
| CHEMBL224571 | 85120 | None | 0 | Human | Binding | pIC50 | = | 7.8 | 7.8 | - | 0 | ChEMBL | 481 | 7 | 1 | 4 | 6.2 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 | 10.1021/jm0492507 | |||
| 44412232 | 166415 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 391 | 6 | 2 | 5 | 4.5 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL427221 | 166415 | None | 0 | Human | Binding | pIC50 | = | 6.8 | 6.8 | - | 0 | ChEMBL | 391 | 6 | 2 | 5 | 4.5 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](C(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| 46885798 | 8033 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 561 | 10 | 4 | 5 | 5.7 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 | 10.1016/j.bmcl.2010.02.098 | |||
| CHEMBL1090829 | 8033 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 561 | 10 | 4 | 5 | 5.7 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 | 10.1016/j.bmcl.2010.02.098 | |||
| 44412165 | 77790 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL209076 | 77790 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| 49830724 | 72409 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 399 | 6 | 1 | 3 | 4.5 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)cc2Cl)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL1986265 | 72409 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 399 | 6 | 1 | 3 | 4.5 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)cc2Cl)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 49830723 | 72757 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 383 | 6 | 1 | 3 | 3.9 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)cc2F)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL1998478 | 72757 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 383 | 6 | 1 | 3 | 3.9 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)cc2F)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451819 | 136903 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 383 | 6 | 1 | 3 | 3.9 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)c(F)c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741572 | 136903 | None | 0 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 383 | 6 | 1 | 3 | 3.9 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)c(F)c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2010.02.098 | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2010.02.098 | |||
| 911 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2010.02.098 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2010.02.098 | |||
| 10287034 | 66204 | None | 2 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 367 | 11 | 2 | 2 | 4.7 | CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL184349 | 66204 | None | 2 | Human | Binding | pIC50 | = | 8.7 | 8.7 | - | 0 | ChEMBL | 367 | 11 | 2 | 2 | 4.7 | CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| 44565597 | 179393 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 436 | 12 | 4 | 5 | 3.2 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCCc2ccccc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL473156 | 179393 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 436 | 12 | 4 | 5 | 3.2 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCCc2ccccc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| 11696807 | 126024 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 391 | 5 | 1 | 5 | 4.2 | CC(C)(C)c1ccc(-c2noc(-c3ccc(CN4CC(C(=O)O)C4)cc3)n2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL364899 | 126024 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 391 | 5 | 1 | 5 | 4.2 | CC(C)(C)c1ccc(-c2noc(-c3ccc(CN4CC(C(=O)O)C4)cc3)n2)cc1 | 10.1021/jm0503244 | |||
| 44412416 | 78226 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 431 | 6 | 2 | 5 | 5.7 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL210520 | 78226 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 431 | 6 | 2 | 5 | 5.7 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| 44412233 | 78166 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 405 | 7 | 2 | 5 | 4.9 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL210352 | 78166 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 405 | 7 | 2 | 5 | 4.9 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CC(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| 44565716 | 179849 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 493 | 10 | 4 | 5 | 4.6 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL474418 | 179849 | None | 0 | Human | Binding | pIC50 | = | 6.7 | 6.7 | - | 0 | ChEMBL | 493 | 10 | 4 | 5 | 4.6 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 | 10.1016/j.bmcl.2009.02.073 | |||
| 44413365 | 77411 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 467 | 6 | 2 | 5 | 5.8 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCC(F)(F)CC5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL208648 | 77411 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 467 | 6 | 2 | 5 | 5.8 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCC(F)(F)CC5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 11168252 | 85118 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 515 | 7 | 1 | 4 | 6.5 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(C(F)(F)F)c2)C1 | 10.1021/jm0492507 | |||
| CHEMBL224549 | 85118 | None | 0 | Human | Binding | pIC50 | = | 7.7 | 7.7 | - | 0 | ChEMBL | 515 | 7 | 1 | 4 | 6.5 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(C(F)(F)F)c2)C1 | 10.1021/jm0492507 | |||
| 107970 | 1639 | None | 56 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1021/jm0492507 | |||
| 107970.0 | 1639 | None | 56 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1021/jm0492507 | |||
| 2407 | 1639 | None | 56 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1021/jm0492507 | |||
| 4167 | 1639 | None | 56 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1021/jm0492507 | |||
| CHEMBL314854 | 1639 | None | 56 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1021/jm0492507 | |||
| DB08868 | 1639 | None | 56 | Human | Binding | pIC50 | = | 5.7 | 5.7 | - | 0 | ChEMBL | 307 | 12 | 3 | 3 | 3.2 | CCCCCCCCc1ccc(cc1)CCC(CO)(CO)N | 10.1021/jm0492507 | |||
| 59451797 | 136989 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 335 | 4 | 1 | 2 | 4.2 | O=C(O)C1CN(Cc2ccc(-c3ccc(Cl)c(Cl)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3742345 | 136989 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 335 | 4 | 1 | 2 | 4.2 | O=C(O)C1CN(Cc2ccc(-c3ccc(Cl)c(Cl)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10127475 | 166124 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 447 | 7 | 1 | 4 | 5.5 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL425563 | 166124 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 447 | 7 | 1 | 4 | 5.5 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 10127475 | 166124 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 447 | 7 | 1 | 4 | 5.5 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1021/jm0492507 | |||
| CHEMBL425563 | 166124 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 447 | 7 | 1 | 4 | 5.5 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1021/jm0492507 | |||
| 44394161 | 67046 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 389 | 16 | 2 | 2 | 6.1 | CCCCCCCCCCCCCC1CCCCN1CCCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL187061 | 67046 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 389 | 16 | 2 | 2 | 6.1 | CCCCCCCCCCCCCC1CCCCN1CCCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| 44394116 | 66371 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 349 | 17 | 2 | 2 | 5.2 | CCCCCCCCCCCCCCN(C)CCCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL185100 | 66371 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 349 | 17 | 2 | 2 | 5.2 | CCCCCCCCCCCCCCN(C)CCCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| 46872507 | 136754 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 311 | 6 | 1 | 3 | 3.3 | CC(Oc1ccc(CN2CC(C(=O)O)C2)cc1)c1ccccc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740188 | 136754 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 311 | 6 | 1 | 3 | 3.3 | CC(Oc1ccc(CN2CC(C(=O)O)C2)cc1)c1ccccc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451779 | 136672 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 305 | 9 | 1 | 3 | 3.6 | CCCCCCOc1ccc(CN2CC[C@@H](C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739509 | 136672 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 305 | 9 | 1 | 3 | 3.6 | CCCCCCOc1ccc(CN2CC[C@@H](C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 44565622 | 179446 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 428 | 11 | 4 | 5 | 3.6 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCC2CCCCC2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL473562 | 179446 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 428 | 11 | 4 | 5 | 3.6 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCC2CCCCC2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| 44394211 | 67184 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 375 | 14 | 2 | 3 | 5.4 | CCCCCCCCCCCCCCN1CCC(O)(P(C)(=O)O)CC1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL187645 | 67184 | None | 0 | Human | Binding | pIC50 | = | 6.6 | 6.6 | - | 0 | ChEMBL | 375 | 14 | 2 | 3 | 5.4 | CCCCCCCCCCCCCCN1CCC(O)(P(C)(=O)O)CC1 | 10.1016/j.bmcl.2004.07.049 | |||
| 46872872 | 136729 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 333 | 9 | 1 | 3 | 4.2 | CCCCCCOc1ccc(CN2CCC(C(=O)O)C(C)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739964 | 136729 | None | 0 | Human | Binding | pIC50 | = | 7.6 | 7.6 | - | 0 | ChEMBL | 333 | 9 | 1 | 3 | 4.2 | CCCCCCOc1ccc(CN2CCC(C(=O)O)C(C)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10215259 | 85141 | None | 4 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 331 | 11 | 1 | 2 | 4.9 | CCCCCCCCCc1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/jm0492507 | |||
| CHEMBL224703 | 85141 | None | 4 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 331 | 11 | 1 | 2 | 4.9 | CCCCCCCCCc1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/jm0492507 | |||
| 59451870 | 136746 | None | 1 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 277 | 7 | 1 | 3 | 2.6 | CC(C)CCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740090 | 136746 | None | 1 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 277 | 7 | 1 | 3 | 2.6 | CC(C)CCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451813 | 136774 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 295 | 5 | 1 | 2 | 3.4 | CCc1ccc(-c2ccc(CN3CC(C(=O)O)C3)cc2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740359 | 136774 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 295 | 5 | 1 | 2 | 3.4 | CCc1ccc(-c2ccc(CN3CC(C(=O)O)C3)cc2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1039/d1md00357g | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1039/d1md00357g | |||
| 911 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1039/d1md00357g | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1039/d1md00357g | |||
| 10883396 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2017.12.010 | |||
| 5283560 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2017.12.010 | |||
| 911 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2017.12.010 | |||
| CHEMBL225155 | 3649 | None | 30 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 4 | ChEMBL | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10.1016/j.bmcl.2017.12.010 | |||
| 44591264 | 180085 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 420 | 13 | 4 | 5 | 3.3 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)c(F)c1 | 10.1016/j.bmcl.2008.11.072 | |||
| CHEMBL474688 | 180085 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 420 | 13 | 4 | 5 | 3.3 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)c(F)c1 | 10.1016/j.bmcl.2008.11.072 | |||
| 44565739 | 179066 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 459 | 12 | 4 | 5 | 4.2 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCCc3ccccc3)cc2)c[nH]1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL470511 | 179066 | None | 0 | Human | Binding | pIC50 | = | 8.5 | 8.5 | - | 0 | ChEMBL | 459 | 12 | 4 | 5 | 4.2 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCCCCCc3ccccc3)cc2)c[nH]1 | 10.1016/j.bmcl.2009.02.073 | |||
| 44412294 | 138736 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 419 | 8 | 2 | 5 | 5.3 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL377637 | 138736 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 419 | 8 | 2 | 5 | 5.3 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| 44412353 | 166323 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 435 | 6 | 2 | 5 | 5.5 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)c(F)c4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL426688 | 166323 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 435 | 6 | 2 | 5 | 5.5 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)c(F)c4)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| 11495139 | 138991 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 405 | 7 | 2 | 5 | 4.7 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@H](CC(=O)O)CN4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL378300 | 138991 | None | 0 | Human | Binding | pIC50 | = | 6.5 | 6.5 | - | 0 | ChEMBL | 405 | 7 | 2 | 5 | 4.7 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@H]4C[C@H](CC(=O)O)CN4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.090 | |||
| 54582607 | 62479 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 375 | 3 | 2 | 3 | 5.8 | Cc1cc(O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | 10.1016/j.bmcl.2011.04.097 | |||
| CHEMBL1779895 | 62479 | None | 0 | Human | Binding | pIC50 | = | 5.5 | 5.5 | - | 0 | ChEMBL | 375 | 3 | 2 | 3 | 5.8 | Cc1cc(O)cc(C)c1NC(=O)c1ccc(-c2cc(Cl)ccc2Cl)o1 | 10.1016/j.bmcl.2011.04.097 | |||
| 11752659 | 166239 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 515 | 7 | 1 | 4 | 6.8 | O=C(O)C1CN(Cc2cc(Cl)c(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 | 10.1021/jm0492507 | |||
| CHEMBL426191 | 166239 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 515 | 7 | 1 | 4 | 6.8 | O=C(O)C1CN(Cc2cc(Cl)c(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Cl)c2)C1 | 10.1021/jm0492507 | |||
| 44394153 | 66177 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 363 | 14 | 3 | 3 | 4.3 | CCCCCCCCCCCCCCN1CCC(O)(P(=O)(O)O)C1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL184237 | 66177 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 363 | 14 | 3 | 3 | 4.3 | CCCCCCCCCCCCCCN1CCC(O)(P(=O)(O)O)C1 | 10.1016/j.bmcl.2004.07.049 | |||
| 59451739 | 136812 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 311 | 6 | 1 | 3 | 3.1 | Cc1ccccc1COc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740768 | 136812 | None | 0 | Human | Binding | pIC50 | = | 7.5 | 7.5 | - | 0 | ChEMBL | 311 | 6 | 1 | 3 | 3.1 | Cc1ccccc1COc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 44413415 | 138777 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 461 | 7 | 2 | 4 | 6.1 | O=C(O)CC1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL377855 | 138777 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 461 | 7 | 2 | 4 | 6.1 | O=C(O)CC1CNC(c2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 11653967 | 70598 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 389 | 6 | 1 | 5 | 4.2 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCC5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| CHEMBL194898 | 70598 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 389 | 6 | 1 | 5 | 4.2 | O=C(O)C1CN(Cc2ccc(-c3noc(-c4ccc(C5CCC5)cc4)n3)cc2)C1 | 10.1021/jm0503244 | |||
| 49830828 | 71839 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)cc3Cl)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL1968499 | 71839 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)cc3Cl)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 49830725 | 71915 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 365 | 6 | 1 | 3 | 3.8 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL1971132 | 71915 | None | 0 | Human | Binding | pIC50 | = | 8.4 | 8.4 | - | 0 | ChEMBL | 365 | 6 | 1 | 3 | 3.8 | O=C(O)C1CN(Cc2ccc(OCc3cccc(C(F)(F)F)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 44394149 | 124094 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 377 | 15 | 3 | 3 | 4.5 | CCCCCCCCCCCCCCN1CCC(C(O)P(=O)(O)O)C1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL363008 | 124094 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 377 | 15 | 3 | 3 | 4.5 | CCCCCCCCCCCCCCN1CCC(C(O)P(=O)(O)O)C1 | 10.1016/j.bmcl.2004.07.049 | |||
| 59451824 | 136960 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 335 | 4 | 1 | 2 | 3.9 | O=C(O)C1CN(Cc2ccc(-c3cccc(C(F)(F)F)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3742100 | 136960 | None | 0 | Human | Binding | pIC50 | = | 6.4 | 6.4 | - | 0 | ChEMBL | 335 | 4 | 1 | 2 | 3.9 | O=C(O)C1CN(Cc2ccc(-c3cccc(C(F)(F)F)c3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451859 | 136925 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 315 | 6 | 1 | 3 | 2.9 | O=C(O)C1CN(Cc2ccc(OCc3ccccc3)c(F)c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741775 | 136925 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 315 | 6 | 1 | 3 | 2.9 | O=C(O)C1CN(Cc2ccc(OCc3ccccc3)c(F)c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 11248292 | 143593 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 465 | 7 | 1 | 4 | 5.7 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(F)c2)C1 | 10.1021/jm0492507 | |||
| CHEMBL389880 | 143593 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 465 | 7 | 1 | 4 | 5.7 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(F)c2)C1 | 10.1021/jm0492507 | |||
| 44565596 | 189655 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 422 | 11 | 4 | 5 | 2.9 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccccc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL514302 | 189655 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 422 | 11 | 4 | 5 | 2.9 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccccc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| 11540052 | 180673 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 470 | 10 | 4 | 5 | 3.7 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2010.02.098 | |||
| CHEMBL475405 | 180673 | None | 0 | Human | Binding | pIC50 | = | 7.4 | 7.4 | - | 0 | ChEMBL | 470 | 10 | 4 | 5 | 3.7 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2010.02.098 | |||
| 11690779 | 189824 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 442 | 8 | 4 | 5 | 3.9 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(Oc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL515603 | 189824 | None | 0 | Human | Binding | pIC50 | = | 6.3 | 6.3 | - | 0 | ChEMBL | 442 | 8 | 4 | 5 | 3.9 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(Oc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| 2926 | 3595 | None | 50 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 440 | 3 | 0 | 4 | 7.2 | FC(c1sc(cc1c1ccccc1)c1onc(n1)c1cccc(c1)C(F)(F)F)(F)F | 10.1021/jm0492507 | |||
| 4077460 | 3595 | None | 50 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 440 | 3 | 0 | 4 | 7.2 | FC(c1sc(cc1c1ccccc1)c1onc(n1)c1cccc(c1)C(F)(F)F)(F)F | 10.1021/jm0492507 | |||
| CHEMBL224720 | 3595 | None | 50 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 1 | ChEMBL | 440 | 3 | 0 | 4 | 7.2 | FC(c1sc(cc1c1ccccc1)c1onc(n1)c1cccc(c1)C(F)(F)F)(F)F | 10.1021/jm0492507 | |||
| 11501764 | 134468 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 379 | 7 | 1 | 6 | 3.3 | CCOc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL371743 | 134468 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 379 | 7 | 1 | 6 | 3.3 | CCOc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| 127041987 | 136715 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 319 | 11 | 1 | 3 | 3.9 | CCCCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739878 | 136715 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 319 | 11 | 1 | 3 | 3.9 | CCCCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 46872620 | 136747 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 383 | 6 | 1 | 3 | 4.2 | O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)c(F)c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740093 | 136747 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 383 | 6 | 1 | 3 | 4.2 | O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)c(F)c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451845 | 136842 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 410 | 7 | 1 | 5 | 4.0 | O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)c([N+](=O)[O-])c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741022 | 136842 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 410 | 7 | 1 | 5 | 4.0 | O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)c([N+](=O)[O-])c2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451849 | 136872 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 383 | 6 | 1 | 3 | 4.2 | O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2F)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741298 | 136872 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 383 | 6 | 1 | 3 | 4.2 | O=C(O)C1CN(Cc2ccc(OCc3ccc(Cl)c(Cl)c3)cc2F)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 44413349 | 77668 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.4 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL208838 | 77668 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 453 | 6 | 2 | 5 | 5.4 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc([C@@H]5CCC(F)(F)C5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 10249887 | 70952 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 391 | 5 | 1 | 5 | 4.2 | CC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL195141 | 70952 | None | 0 | Human | Binding | pIC50 | = | 8.3 | 8.3 | - | 0 | ChEMBL | 391 | 5 | 1 | 5 | 4.2 | CC(C)(C)c1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| 44413482 | 166133 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 445 | 7 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL425602 | 166133 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 445 | 7 | 2 | 5 | 5.0 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(CCC(F)(F)F)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 11466640 | 85124 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 525 | 7 | 1 | 4 | 6.3 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Br)c2)C1 | 10.1021/jm0492507 | |||
| CHEMBL224599 | 85124 | None | 0 | Human | Binding | pIC50 | = | 7.3 | 7.3 | - | 0 | ChEMBL | 525 | 7 | 1 | 4 | 6.3 | O=C(O)C1CN(Cc2ccc(OCc3cc(-c4ccccc4)c(C(F)(F)F)s3)c(Br)c2)C1 | 10.1021/jm0492507 | |||
| 10312 | 1294 | None | 27 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 388 | 4 | 2 | 3 | 5.6 | NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2011.04.097 | |||
| 53358422 | 1294 | None | 27 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 388 | 4 | 2 | 3 | 5.6 | NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2011.04.097 | |||
| CHEMBL1779732 | 1294 | None | 27 | Human | Binding | pIC50 | = | 5.3 | 5.3 | - | 0 | ChEMBL | 388 | 4 | 2 | 3 | 5.6 | NCc1cc(C)c(c(c1)C)NC(=O)c1ccc(o1)c1cc(Cl)ccc1Cl | 10.1016/j.bmcl.2011.04.097 | |||
| 44413447 | 138770 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 431 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL377828 | 138770 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 431 | 6 | 2 | 5 | 5.6 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCCC5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 46872626 | 215 | None | 30 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| 9496 | 215 | None | 30 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741589 | 215 | None | 30 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 1 | ChEMBL | 365 | 6 | 1 | 3 | 4.1 | OC(=O)C1CN(C1)Cc1ccc(cc1)OCc1ccc(c(c1)Cl)Cl | 10.1021/acs.jmedchem.5b00928 | |||
| 46872622 | 72461 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 331 | 6 | 1 | 3 | 3.4 | O=C(O)C1CN(Cc2ccc(OCc3ccccc3)cc2Cl)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL1987998 | 72461 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 331 | 6 | 1 | 3 | 3.4 | O=C(O)C1CN(Cc2ccc(OCc3ccccc3)cc2Cl)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10287034 | 66204 | None | 2 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 367 | 11 | 2 | 2 | 4.7 | CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 | 10.1021/jm0492507 | |||
| CHEMBL184349 | 66204 | None | 2 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 367 | 11 | 2 | 2 | 4.7 | CCCCCCCCCc1ccc(CN2CCC(P(=O)(O)O)C2)cc1 | 10.1021/jm0492507 | |||
| 10409838 | 134253 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 419 | 10 | 1 | 5 | 5.0 | CCCCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL371670 | 134253 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 419 | 10 | 1 | 5 | 5.0 | CCCCCCc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| 10476387 | 127582 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 405 | 6 | 1 | 5 | 4.5 | CC(C)(C)Cc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| CHEMBL366181 | 127582 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 405 | 6 | 1 | 5 | 4.5 | CC(C)(C)Cc1ccc(-c2nc(-c3ccc(CN4CC(C(=O)O)C4)cc3)no2)cc1 | 10.1021/jm0503244 | |||
| 44591250 | 189863 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 420 | 13 | 4 | 5 | 3.3 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F | 10.1016/j.bmcl.2008.11.072 | |||
| CHEMBL515921 | 189863 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 420 | 13 | 4 | 5 | 3.3 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1F | 10.1016/j.bmcl.2008.11.072 | |||
| 44412428 | 78324 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 435 | 6 | 2 | 5 | 5.5 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4F)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL210782 | 78324 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 435 | 6 | 2 | 5 | 5.5 | O=C(O)C[C@@H]1CC[C@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4F)n3)cc2)N1 | 10.1016/j.bmcl.2006.03.038 | |||
| 44394212 | 67191 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 373 | 15 | 2 | 2 | 6.5 | CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL187692 | 67191 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 373 | 15 | 2 | 2 | 6.5 | CCCCCCCCCCCCCC1CCCC(CCP(C)(=O)O)N1 | 10.1016/j.bmcl.2004.07.049 | |||
| 44394169 | 66704 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 375 | 16 | 2 | 2 | 5.7 | CCCCCCCCCCCCCCN1CCCC1CCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL185447 | 66704 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 375 | 16 | 2 | 2 | 5.7 | CCCCCCCCCCCCCCN1CCCC1CCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| 44413446 | 78381 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 417 | 6 | 2 | 5 | 5.2 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| CHEMBL211006 | 78381 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 417 | 6 | 2 | 5 | 5.2 | O=C(O)C[C@@H]1CN[C@@H](c2ccc(-c3noc(-c4ccc(C5CCCC5)cc4)n3)cc2)C1 | 10.1016/j.bmcl.2006.03.090 | |||
| 44394117 | 66362 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 389 | 17 | 2 | 2 | 6.1 | CCCCCCCCCCCCCCC1CCCN1CCCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL185066 | 66362 | None | 0 | Human | Binding | pIC50 | = | 6.2 | 6.2 | - | 0 | ChEMBL | 389 | 17 | 2 | 2 | 6.1 | CCCCCCCCCCCCCCC1CCCN1CCCP(=O)(O)O | 10.1016/j.bmcl.2004.07.049 | |||
| 59451753 | 136994 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 281 | 4 | 1 | 2 | 3.2 | Cc1ccc(-c2ccc(CN3CC(C(=O)O)C3)cc2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3742384 | 136994 | None | 0 | Human | Binding | pIC50 | = | 8.2 | 8.2 | - | 0 | ChEMBL | 281 | 4 | 1 | 2 | 3.2 | Cc1ccc(-c2ccc(CN3CC(C(=O)O)C3)cc2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 44565714 | 179403 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 484 | 11 | 4 | 5 | 4.1 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL473238 | 179403 | None | 0 | Human | Binding | pIC50 | = | 7.2 | 7.2 | - | 0 | ChEMBL | 484 | 11 | 4 | 5 | 4.1 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| 59451780 | 136889 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 305 | 9 | 1 | 3 | 3.6 | CCCCCCOc1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741459 | 136889 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 305 | 9 | 1 | 3 | 3.6 | CCCCCCOc1ccc(CN2CCC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451832 | 136730 | None | 3 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 297 | 6 | 1 | 3 | 2.8 | O=C(O)C1CN(Cc2ccc(OCc3ccccc3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739977 | 136730 | None | 3 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 297 | 6 | 1 | 3 | 2.8 | O=C(O)C1CN(Cc2ccc(OCc3ccccc3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 10310952 | 85155 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 477 | 8 | 1 | 5 | 5.5 | COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 | 10.1021/jm0492507 | |||
| CHEMBL224800 | 85155 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 477 | 8 | 1 | 5 | 5.5 | COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1cc(-c2ccccc2)c(C(F)(F)F)s1 | 10.1021/jm0492507 | |||
| 46872625 | 136757 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 317 | 5 | 1 | 3 | 3.6 | O=C(O)C1CN(Cc2ccc(Oc3ccc(Cl)cc3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740219 | 136757 | None | 0 | Human | Binding | pIC50 | = | 6.1 | 6.1 | - | 0 | ChEMBL | 317 | 5 | 1 | 3 | 3.6 | O=C(O)C1CN(Cc2ccc(Oc3ccc(Cl)cc3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451750 | 136951 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 311 | 6 | 1 | 3 | 3.1 | Cc1cc(OCc2ccccc2)ccc1CN1CC(C(=O)O)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3742033 | 136951 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 311 | 6 | 1 | 3 | 3.1 | Cc1cc(OCc2ccccc2)ccc1CN1CC(C(=O)O)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 11725751 | 12851 | None | 3 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 355 | 14 | 3 | 2 | 4.6 | CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| CHEMBL118860 | 12851 | None | 3 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 355 | 14 | 3 | 2 | 4.6 | CCCCCCCCCc1ccc(CNCCCP(=O)(O)O)cc1 | 10.1016/j.bmcl.2004.07.049 | |||
| 44591249 | 180742 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 402 | 13 | 4 | 5 | 3.2 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2008.11.072 | |||
| CHEMBL475495 | 180742 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 402 | 13 | 4 | 5 | 3.2 | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(=O)(O)O)cc1 | 10.1016/j.bmcl.2008.11.072 | |||
| 44412415 | 78207 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 419 | 8 | 2 | 5 | 5.3 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| CHEMBL210468 | 78207 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 419 | 8 | 2 | 5 | 5.3 | CC(C)Cc1ccc(-c2nc(-c3ccc([C@@H]4CC[C@@H](CCC(=O)O)N4)cc3)no2)cc1 | 10.1016/j.bmcl.2006.03.038 | |||
| 46885796 | 8413 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 538 | 10 | 4 | 5 | 4.8 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.02.098 | |||
| CHEMBL1093429 | 8413 | None | 0 | Human | Binding | pIC50 | = | 7.1 | 7.1 | - | 0 | ChEMBL | 538 | 10 | 4 | 5 | 4.8 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCc2ccc(-c3ccccc3)cc2)c(C(F)(F)F)c1 | 10.1016/j.bmcl.2010.02.098 | |||
| 68489165 | 136696 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 315 | 6 | 1 | 3 | 2.9 | O=C(O)C1CN(Cc2ccc(OCc3ccc(F)cc3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3739695 | 136696 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 315 | 6 | 1 | 3 | 2.9 | O=C(O)C1CN(Cc2ccc(OCc3ccc(F)cc3)cc2)C1 | 10.1021/acs.jmedchem.5b00928 | |||
| 59451764 | 136741 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 291 | 9 | 1 | 3 | 3.2 | CCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3740060 | 136741 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 291 | 9 | 1 | 3 | 3.2 | CCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 46872048 | 136880 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 395 | 7 | 1 | 4 | 4.1 | COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1ccc(Cl)cc1Cl | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741364 | 136880 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 395 | 7 | 1 | 4 | 4.1 | COc1cc(CN2CC(C(=O)O)C2)ccc1OCc1ccc(Cl)cc1Cl | 10.1021/acs.jmedchem.5b00928 | |||
| 127037696 | 136894 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 305 | 10 | 1 | 3 | 3.6 | CCCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| CHEMBL3741496 | 136894 | None | 0 | Human | Binding | pIC50 | = | 8.1 | 8.1 | - | 0 | ChEMBL | 305 | 10 | 1 | 3 | 3.6 | CCCCCCCOc1ccc(CN2CC(C(=O)O)C2)cc1 | 10.1021/acs.jmedchem.5b00928 | |||
| 44565717 | 189639 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 479 | 9 | 4 | 5 | 4.6 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL514170 | 189639 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 479 | 9 | 4 | 5 | 4.6 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 | 10.1016/j.bmcl.2009.02.073 | |||
| 25008420 | 8466 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 547 | 9 | 4 | 5 | 5.6 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 | 10.1016/j.bmcl.2010.02.098 | |||
| CHEMBL1093823 | 8466 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 547 | 9 | 4 | 5 | 5.6 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)c(C(F)(F)F)c2)c[nH]1 | 10.1016/j.bmcl.2010.02.098 | |||
| 44565717 | 189639 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 479 | 9 | 4 | 5 | 4.6 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 | 10.1016/j.bmcl.2010.02.098 | |||
| CHEMBL514170 | 189639 | None | 0 | Human | Binding | pIC50 | = | 8.0 | 8.0 | - | 0 | ChEMBL | 479 | 9 | 4 | 5 | 4.6 | C[C@](N)(COP(=O)(O)O)c1nc(-c2ccc(OCc3ccc(-c4ccccc4)cc3)cc2)c[nH]1 | 10.1016/j.bmcl.2010.02.098 | |||
| 44565715 | 180549 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 498 | 12 | 4 | 5 | 4.5 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| CHEMBL475253 | 180549 | None | 0 | Human | Binding | pIC50 | = | 7 | 7.0 | - | 0 | ChEMBL | 498 | 12 | 4 | 5 | 4.5 | C[C@](N)(COP(=O)(O)O)C(=O)Nc1ccc(OCCCCc2ccc(-c3ccccc3)cc2)cc1 | 10.1016/j.bmcl.2009.02.073 | |||
| 77846754 | 182648 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 435 | 5 | 1 | 3 | 6.3 | Cc1cc(OC2CCC3(CCCC3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4787458 | 182648 | None | 0 | Human | Binding | pKi | = | 9.5 | 9.5 | - | 1 | ChEMBL | 435 | 5 | 1 | 3 | 6.3 | Cc1cc(OC2CCC3(CCCC3)CC2)c(CN2CCC(C(=O)O)CC2)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 11502996 | 158819 | None | 36 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | 435 | 9 | 1 | 4 | 5.0 | CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 | 10.1021/acs.jmedchem.7b00785 | |||
| CHEMBL4093489 | 158819 | None | 36 | Human | Binding | pKi | = | 9.2 | 9.2 | 1 | 4 | ChEMBL | 435 | 9 | 1 | 4 | 5.0 | CCCc1ccc(COc2ccc3c(c2)CCC(CN2CC(C(=O)O)C2)=C3C)c(OC)c1 | 10.1021/acs.jmedchem.7b00785 | |||
| 77847762 | 183529 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 397 | 7 | 2 | 3 | 5.7 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4798593 | 183529 | None | 0 | Human | Binding | pKi | = | 8.9 | 8.9 | - | 1 | ChEMBL | 397 | 7 | 2 | 3 | 5.7 | Cc1cc(O[C@H]2CC[C@H](C(C)(C)C)CC2)c(CNCCC(=O)O)c2ccccc12 | 10.1021/acsmedchemlett.0c00631 | |||
| 12573 | 995 | None | 2 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| 77846592 | 995 | None | 2 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| CHEMBL4748198 | 995 | None | 2 | Human | Binding | pKi | = | 8.4 | 8.4 | - | 1 | ChEMBL | 437 | 5 | 1 | 3 | 6.4 | C(C)(C)(C)[C@@H]1CC[C@H](CC1)OC2=C(C3=CC=CC=C3C(=C2)C)CN4CCC(CC4)C(=O)O | 10.1021/acsmedchemlett.0c00631 | |||
| 11363176 | 3149 | None | 41 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Guide to Pharmacology | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | 20446681 | |||
| 11363176.0 | 3149 | None | 41 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Guide to Pharmacology | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | 20446681 | |||
| 5446 | 3149 | None | 41 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Guide to Pharmacology | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | 20446681 | |||
| 9320 | 3149 | None | 41 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Guide to Pharmacology | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | 20446681 | |||
| CHEMBL1096146 | 3149 | None | 41 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Guide to Pharmacology | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | 20446681 | |||
| DB12016 | 3149 | None | 41 | Human | Binding | pIC50 | = | 6.9 | 6.9 | - | 0 | Guide to Pharmacology | 460 | 8 | 2 | 6 | 4.3 | CCCN=C1S/C(=C\c2ccc(c(c2)Cl)OC[C@@H](CO)O)/C(=O)N1c1ccccc1C | 20446681 | |||
| 6992 | 4009 | None | 0 | Human | Binding | pKd | = | 8.6 | 8.6 | 7 | 5 | Guide to Pharmacology | 369 | 11 | 3 | 3 | 4.3 | CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O | 21632869 | |||
| 73755254 | 4009 | None | 0 | Human | Binding | pKd | = | 8.6 | 8.6 | 7 | 5 | Guide to Pharmacology | 369 | 11 | 3 | 3 | 4.3 | CCCCCCCCc1cccc(c1)C1CC(C1)(N)COP(=O)(O)O | 21632869 | |||
| 10883396 | 3649 | None | 30 | Rat | Binding | pKd | None | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10799507 | |||
| 5283560 | 3649 | None | 30 | Rat | Binding | pKd | None | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10799507 | |||
| 911 | 3649 | None | 30 | Rat | Binding | pKd | None | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10799507 | |||
| CHEMBL225155 | 3649 | None | 30 | Rat | Binding | pKd | None | 8.7 | 8.7 | 1 | 4 | Guide to Pharmacology | 379 | 17 | 4 | 4 | 4.0 | CCCCCCCCCCCCC/C=C/[C@H]([C@H](COP(=O)(O)O)N)O | 10799507 | |||