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Ligand source activities (1 row/activity)

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	145971909	164700	0	None	11	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	411	11	2	6	4.8	CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4217198	164700	0	None	11	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	411	11	2	6	4.8	CCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	66978356	163708	0	None	10	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4204996	163708	0	None	10	3	Human	10.1	pEC50	=	10.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	127027876	139476	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	4.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3794302	139476	0	None	-	1	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	4.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	145978309	163752	0	None	27	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	429	12	2	6	4.8	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCCCF	10.1016/j.bmc.2017.11.035
	CHEMBL4205480	163752	0	None	27	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	429	12	2	6	4.8	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCCCF	10.1016/j.bmc.2017.11.035
	127029692	139404	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793515	139404	0	None	-	1	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	11855868	152544	0	None	24	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152544	0	None	24	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855865	153277	0	None	35	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	153277	0	None	35	3	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127026955	139450	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794016	139450	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
	1883	3082	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	1916	3082	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	5280360	3082	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	913	3082	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	CHEMBL548	3082	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	DB00917	3082	75	None	-2	12	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
	18376258	195902	0	None	-	1	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559065	195902	0	None	-	1	Rat	9.7	pEC50	=	9.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	127026956	139426	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793862	139426	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	126495400	139321	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3792632	139321	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
	1929	1605	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	9890801	1605	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	CHEMBL563646	1605	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	DB12022	1605	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
	67082748	164363	0	None	9	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	451	10	2	6	5.0	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCC(F)(F)F	10.1016/j.bmc.2017.11.035
	CHEMBL4212770	164363	0	None	9	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	451	10	2	6	5.0	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CCC(F)(F)F	10.1016/j.bmc.2017.11.035
	15979081	163840	0	None	5	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4206444	163840	0	None	5	3	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCCC(C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	127051063	140322	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806284	140322	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
	127027877	139419	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.4	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793802	139419	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.4	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	16725337	149601	0	None	4	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149601	0	None	4	4	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11294085	137252	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmc.2017.11.035
	CHEMBL3751951	137252	0	None	1	3	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmc.2017.11.035
	127028169	139490	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	2	6	4.4	CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794466	139490	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	2	6	4.4	CCc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	118352160	139429	0	None	7079	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793892	139429	0	None	7079	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	423	5	2	6	4.1	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	127027874	139363	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793045	139363	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
	127027874	139363	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793045	139363	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	127051656	140294	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805981	140294	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443871	151445	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	8	2	4	5.5	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)O)c1C	nan
	CHEMBL3961932	151445	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	8	2	4	5.5	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(C)ccc(OCC(=O)O)c1C	nan
	89443827	144113	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	395	7	3	4	4.9	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3903635	144113	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	395	7	3	4	4.9	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	18376082	194923	0	None	-	1	Rat	9.0	pEC50	=	9.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541517	194923	0	None	-	1	Rat	9.0	pEC50	=	9.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
	145977227	164007	0	None	-1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4208379	164007	0	None	-1	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	10315	2926	28	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	44230575	2926	28	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	CHEMBL3707245	2926	28	None	1659	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
	126495463	140307	0	None	69	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	6	2	6	3.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806130	140307	0	None	69	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	6	2	6	3.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11502897	142793	0	None	43	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142793	0	None	43	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855870	146280	0	None	467	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	146280	0	None	467	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855868	152544	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152544	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855865	153277	0	None	35	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	153277	0	None	35	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44230722	171729	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	489	10	2	7	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4467099	171729	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	489	10	2	7	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11855868	152544	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3971632	152544	0	None	24	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	127026953	139499	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	439	6	2	7	3.8	COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794585	139499	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	439	6	2	7	3.8	COc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	1883	3082	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	1916	3082	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	5280360	3082	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	913	3082	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	CHEMBL548	3082	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	DB00917	3082	75	None	-6	12	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
	126495398	140211	0	None	416	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	403	7	2	6	3.9	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805044	140211	0	None	416	3	Human	8.0	pEC50	=	8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	403	7	2	6	3.9	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443586	145685	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3916133	145685	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	118517489	143691	0	None	-18	3	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143691	0	None	-18	3	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	92135977	152896	0	None	-141	4	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152896	0	None	-141	4	Human	8.0	pEC50	=	8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	8541	2944	2	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	9824353	2944	2	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL292964	2944	2	None	-66069	4	Human	5.0	pEC50	=	5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	59465571	146285	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920796	146285	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	118517361	153370	0	None	-107	3	Human	6.0	pEC50	=	6.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	153370	0	None	-107	3	Human	6.0	pEC50	=	6.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	11955384	147538	0	None	33	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	360	8	2	3	4.4	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3930718	147538	0	None	33	3	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	360	8	2	3	4.4	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	45268715	195976	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559760	195976	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	16750455	151272	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	342	7	1	2	5.2	CC(C)(C)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3960352	151272	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	342	7	1	2	5.2	CC(C)(C)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	53259980	176369	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	CHEMBL4566584	176369	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595789	176369	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1cccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)c1	10.1021/acs.jmedchem.8b00808
	126495507	139379	0	None	154	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	425	5	1	5	5.1	Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793167	139379	0	None	154	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	425	5	1	5	5.1	Cc1cc(OC[C@H]2[C@@H](F)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	71515776	154356	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	CC(Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3986985	154356	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	CC(Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	44304164	203234	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64483	203234	0	None	-	1	Mouse	8.0	pEC50	=	8.0	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	118517485	142750	0	None	-3	4	Human	8.0	pEC50	=	8.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	CHEMBL3892492	142750	0	None	-3	4	Human	8.0	pEC50	=	8.0	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
	71515515	151004	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	369	7	2	3	4.7	O=C(O)COc1cccc(NCc2cc(-c3cccc(F)c3)ccc2F)c1	nan
	CHEMBL3958411	151004	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	369	7	2	3	4.7	O=C(O)COc1cccc(NCc2cc(-c3cccc(F)c3)ccc2F)c1	nan
	126495427	139466	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	422	5	2	5	4.7	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4csc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794185	139466	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	422	5	2	5	4.7	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4csc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	11955193	143584	0	None	10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	378	7	2	2	5.3	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3899346	143584	0	None	10	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	378	7	2	2	5.3	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	155550016	176682	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4539881	176682	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598324	176682	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	13	2	6	3.6	O=C(O)CNc1cccc(CN(CCCCCc2ccccc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	53260150	176532	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4451786	176532	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597091	176532	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	9	2	6	3.4	O=C(O)CNc1cccc(CN(Cc2ccc(C(F)(F)F)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	11855590	144374	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	144374	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855591	144436	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	144436	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	11855591	144436	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	144436	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	118517360	143975	0	None	-61	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	CHEMBL3902700	143975	0	None	-61	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
	118517489	143691	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	CHEMBL3900245	143691	0	None	-18	3	Human	6.9	pEC50	=	6.9	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
	11955257	153886	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3983069	153886	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	118352211	139385	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793209	139385	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1016/j.bmcl.2016.03.110
	118352211	139385	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793209	139385	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	375	5	2	6	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	126495491	140225	0	None	28	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	429	8	2	6	4.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805169	140225	0	None	28	4	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	429	8	2	6	4.5	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127050452	140244	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(C(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805408	140244	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(C(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	53260293	176213	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.2	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CCC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594090	176213	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.2	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CCC1	10.1021/acs.jmedchem.8b00808
	89443700	152586	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1F	nan
	CHEMBL3971868	152586	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1F	nan
	89444072	148944	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(-c2cccc(F)c2)ccc(F)c1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3941975	148944	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(-c2cccc(F)c2)ccc(F)c1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	44303952	100886	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293697	100886	0	None	-	1	Mouse	6.9	pEC50	=	6.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	10270893	94228	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249954	94228	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	9885481	195383	0	None	14	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	CHEMBL551951	195383	0	None	14	2	Rat	6.9	pEC50	=	6.9	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
	11855325	144691	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144691	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855325	144691	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144691	0	None	19	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	127050451	140221	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805122	140221	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443781	149278	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2cc(-c3ccc(F)c(F)c3)ccc2F)c1F	nan
	CHEMBL3944601	149278	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2cc(-c3ccc(F)c(F)c3)ccc2F)c1F	nan
	10481859	75167	0	None	-67	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	CHEMBL2036321	75167	0	None	-67	2	Rat	5.9	pEC50	=	5.9	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
	44303627	203205	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64358	203205	0	None	-	1	Mouse	5.9	pEC50	=	5.9	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	134146425	149203	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3943966	149203	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11855591	144436	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	CHEMBL3906402	144436	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
	10291963	84708	0	None	-32	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL222715	84708	0	None	-32	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	127029402	139358	0	None	524	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	407	5	2	6	3.6	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793009	139358	0	None	524	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	407	5	2	6	3.6	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)co4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	24760052	151185	0	None	24	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	151185	0	None	24	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	17751059	148268	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	148268	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	89444124	143431	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(-c2ccccc2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3898152	143431	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(-c2ccccc2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	156014791	177584	0	None	-309	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	439	11	2	4	5.0	CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	CHEMBL4640635	177584	0	None	-309	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	439	11	2	4	5.0	CCCCCC(O)CCc1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	57464006	75168	0	None	-288	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036322	75168	0	None	-288	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	10269242	155575	0	None	-54	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL404413	155575	0	None	-54	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	59465577	143189	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896183	143189	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	59465570	143259	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3896693	143259	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
	134143292	145228	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3912658	145228	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465574	145945	0	None	1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	CHEMBL3918084	145945	0	None	1	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
	59465601	149894	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3949271	149894	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	58681356	150371	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	7	3	4	3.9	O=C(O)COCC#CCC1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3953307	150371	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	7	3	4	3.9	O=C(O)COCC#CCC1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44442327	94459	0	None	-891	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251294	94459	0	None	-891	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	11855870	146280	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	146280	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	11855870	146280	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3920756	146280	0	None	467	3	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	71515516	148306	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	387	7	2	3	4.8	O=C(O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3936868	148306	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	387	7	2	3	4.8	O=C(O)COc1ccc(F)c(NCc2cccc(-c3cccc(F)c3)c2)c1F	nan
	71516448	152560	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	3	4	4.7	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2F)c1F	nan
	CHEMBL3971730	152560	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	3	4	4.7	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2F)c1F	nan
	57893848	75169	0	None	-724	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036323	75169	0	None	-724	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
	118517488	153711	0	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153711	0	None	-14	3	Human	6.8	pEC50	=	6.8	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	58708286	154344	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc([C@H](O)C2CCCCC2)cc1	nan
	CHEMBL3986874	154344	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc([C@H](O)C2CCCCC2)cc1	nan
	1929	1605	55	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	9890801	1605	55	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	CHEMBL563646	1605	55	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	DB12022	1605	55	None	-2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
	89444254	142780	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F	nan
	CHEMBL3892751	142780	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	423	7	2	3	5.1	O=C(O)COc1ccc(F)c(NCc2c(F)ccc(-c3cccc(F)c3)c2F)c1F	nan
	89443784	142906	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	431	8	2	4	5.2	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3893770	142906	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	431	8	2	4	5.2	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	89444126	147388	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	403	7	3	4	4.6	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3929662	147388	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	403	7	3	4	4.6	O=C(O)COc1ccc(F)c(NCc2cc(O)cc(-c3cccc(F)c3)c2)c1F	nan
	11955383	142533	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	2	3	4.2	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3890808	142533	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	2	3	4.2	CC(C)(C)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	53260155	171404	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.1	CC(C)C1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4462507	171404	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	11	2	6	4.1	CC(C)C1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	117703250	143639	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	C[C@@H](Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3899837	143639	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.5	C[C@@H](Nc1c(F)ccc(OCC(=O)O)c1F)c1cc(-c2cccc(F)c2)ccc1F	nan
	89444132	143866	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	8	2	4	4.9	COc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3901709	143866	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	8	2	4	4.9	COc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	89443635	151904	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(OCC(=O)O)c(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3965998	151904	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(OCC(=O)O)c(C)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	57394893	71306	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957435	71306	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
	10291963	84708	0	None	-3801	4	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmc.2012.02.018
	CHEMBL222715	84708	0	None	-3801	4	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmc.2012.02.018
	57394893	71306	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957435	71306	0	None	-223	2	Rat	5.8	pEC50	=	5.8	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
	11855867	145983	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145983	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855867	145983	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145983	0	None	10	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	44455115	95562	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL257658	95562	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	1883	3082	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	1916	3082	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	5280360	3082	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	913	3082	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	CHEMBL548	3082	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	DB00917	3082	75	None	-2	12	Rat	7.7	pEC50	=	7.7	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
	53259985	176477	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4548451	176477	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596602	176477	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	497	10	2	6	4.3	COc1ccc(S(=O)(=O)N(Cc2ccc(C(C)(C)C)cc2)Cc2cccc(NCC(=O)O)n2)cc1	10.1021/acs.jmedchem.8b00808
	44442332	94527	0	None	-97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251709	94527	0	None	-97	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	127026952	139361	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	451	6	2	6	4.9	CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3793020	139361	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	451	6	2	6	4.9	CC(C)c1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	59465581	144112	0	None	22	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	144112	0	None	22	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	145966519	164399	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4213312	164399	0	None	15	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	437	10	2	6	5.2	C[C@](O)(C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1)CC1CCCC1	10.1016/j.bmc.2017.11.035
	44230429	176328	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4471378	176328	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595426	176328	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	488	10	2	6	4.0	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccccc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	89443841	145895	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	407	7	2	3	5.8	Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)O)c2C)c1C	nan
	CHEMBL3917749	145895	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	407	7	2	3	5.8	Cc1cc(-c2cccc(F)c2)cc(CNc2c(C)ccc(OCC(=O)O)c2C)c1C	nan
	89444231	146113	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3919482	146113	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	89443843	148797	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3940781	148797	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2ccc(F)c(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	89443583	150478	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1F	nan
	CHEMBL3954347	150478	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1F	nan
	66857988	164122	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	428	12	2	7	4.0	CCCCCC(C)(O)C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4209929	164122	0	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	428	12	2	7	4.0	CCCCCC(C)(O)C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	5283086	203310	24	None	-10	4	Mouse	8.7	pEC50	=	8.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL64804	203310	24	None	-10	4	Mouse	8.7	pEC50	=	8.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
	118352285	139469	0	None	2398	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3794226	139469	0	None	2398	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4ccc(C(=O)O)o4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	18376196	194922	0	None	-	1	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL541516	194922	0	None	-	1	Rat	8.6	pEC50	=	8.6	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
	70815687	176546	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4515583	176546	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597208	176546	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	466	10	2	6	3.4	CC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	138	3081	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	1882	3081	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	5280723	3081	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	CHEMBL495	3081	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	DB00770	3081	88	None	-1	10	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
	53260134	176262	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4466224	176262	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594970	176262	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.8b00808
	53259986	176520	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4442505	176520	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596979	176520	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccn2)cc1	10.1021/acs.jmedchem.8b00808
	53259987	176498	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4591201	176498	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596748	176498	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	6	3.7	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	9807448	203172	0	None	1	2	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64246	203172	0	None	1	2	Mouse	8.6	pEC50	=	8.6	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	118352215	139417	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	403	5	2	6	3.8	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1C	10.1016/j.bmcl.2016.03.110
	CHEMBL3793797	139417	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	403	5	2	6	3.8	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1C	10.1016/j.bmcl.2016.03.110
	11855865	153277	0	None	35	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3977724	153277	0	None	35	3	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	10126807	195098	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549869	195098	0	None	-	1	Rat	6.7	pEC50	=	6.7	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11955273	152787	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	438	10	3	4	4.6	O=C(O)COCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3973644	152787	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	438	10	3	4	4.6	O=C(O)COCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	138107701	187464	46	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	5311181	187464	46	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	CHEMBL494	187464	46	None	-1348	7	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	10.1016/j.ejmech.2022.114154
	59465583	143274	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	CHEMBL3896863	143274	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	398	9	2	3	5.6	O=C(O)CCC/C=C\C[C@H]1C(=O)CC[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	11855594	152980	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152980	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152980	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152980	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	146408	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	146408	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855871	146408	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	146408	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	54013831	146460	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3922151	146460	0	None	1	2	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	10363130	101035	1	None	-	1	Mouse	6.7	pEC50	=	6.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL294585	101035	1	None	-	1	Mouse	6.7	pEC50	=	6.7	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9975502	94489	0	None	-14	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251504	94489	0	None	-14	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	24760052	151185	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3959769	151185	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
	70667255	151474	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3962183	151474	0	None	24	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
	72950089	150591	0	None	-4365	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL3955128	150591	0	None	-4365	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
	11955180	151660	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2ccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)cc2)CCC1	nan
	CHEMBL3963968	151660	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2ccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)cc2)CCC1	nan
	10089562	154422	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL398948	154422	0	None	-1	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	118352177	139412	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	1	6	4.8	CO[C@H]1C[C@@H]2O[C@@H](c3nc(C(=O)O)cs3)CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793724	139412	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	437	6	1	6	4.8	CO[C@H]1C[C@@H]2O[C@@H](c3nc(C(=O)O)cs3)CC[C@@H]2[C@H]1COc1ccc(Cl)c(C)c1	10.1016/j.bmcl.2016.03.110
	127051064	140299	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3F)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806060	140299	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3F)O2)n1	10.1021/acsmedchemlett.5b00455
	89443417	151592	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F	nan
	CHEMBL3963438	151592	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2Cl)c1F	nan
	44455046	95727	0	None	-8317	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL258332	95727	0	None	-8317	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
	56839536	143169	0	None	-141	7	Human	5.6	pEC50	=	5.6	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	604	15	2	7	5.1	CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1	nan
	CHEMBL3896035	143169	0	None	-141	7	Human	5.6	pEC50	=	5.6	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	604	15	2	7	5.1	CCCCCCCCNC(=O)c1coc([C@@H]2CCCN2Cc2cc(F)ccc2CCC(=O)NS(=O)(=O)C(F)(F)F)n1	nan
	57529188	147195	0	None	19	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	147195	0	None	19	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	89443813	151738	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3964577	151738	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	118517359	144396	0	None	-79	4	Human	7.6	pEC50	=	7.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	144396	0	None	-79	4	Human	7.6	pEC50	=	7.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	57384034	71307	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	CHEMBL1957436	71307	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
	57384034	71307	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL1957436	71307	0	None	-9	2	Rat	6.6	pEC50	=	6.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
	11955194	151003	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	2	2	5.5	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3958410	151003	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	2	2	5.5	CC(C)(C)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	58708282	153124	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	412	11	2	3	6.0	CCCC1([C@@H](O)c2cccc([C@H]3CCC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3976452	153124	0	None	1	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	412	11	2	3	6.0	CCCC1([C@@H](O)c2cccc([C@H]3CCC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	58681352	154339	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	CHEMBL3986829	154339	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
	126495360	140234	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805316	140234	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1ccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc1	10.1021/acsmedchemlett.5b00455
	11855866	144602	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144602	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	89443595	144961	5	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3910551	144961	5	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	57894053	75170	0	None	-208	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	CHEMBL2036324	75170	0	None	-208	2	Rat	5.6	pEC50	=	5.6	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
	118517359	144396	0	None	-79	4	Human	6.6	pEC50	=	6.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	144396	0	None	-79	4	Human	6.6	pEC50	=	6.6	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	126495420	140249	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	9	2	6	4.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805455	140249	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	9	2	6	4.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3CCCCCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11855324	142605	0	None	14	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142605	0	None	14	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	71515514	147626	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3931335	147626	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	11955198	147243	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	10	3	3	5.8	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3928466	147243	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	10	3	3	5.8	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	155541719	176382	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4519118	176382	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595870	176382	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	9	1	6	3.7	CN(CC(=O)O)c1cccc(CN(Cc2ccc(C(C)(C)C)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	132836	59695	23	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL1722929	59695	23	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	155532079	171689	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	10	2	6	4.4	O=C(O)CNc1cccc(CN(Cc2ccc(C3CCCCC3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4466523	171689	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	494	10	2	6	4.4	O=C(O)CNc1cccc(CN(Cc2ccc(C3CCCCC3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	44455084	97867	0	None	-10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	CHEMBL272277	97867	0	None	-10	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
	59465581	144112	0	None	22	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3903611	144112	0	None	22	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	89443767	145712	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	409	8	2	4	5.2	COc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3916293	145712	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	409	8	2	4	5.2	COc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	89443716	147026	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3926711	147026	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	397	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	89443671	147838	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3932999	147838	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	89445501	152276	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)cc(F)c1C	nan
	CHEMBL3969269	152276	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1ccc(OCC(=O)O)c(C)c1NCc1cc(-c2cccc(F)c2)cc(F)c1C	nan
	89443873	153940	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3983500	153940	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	127051062	140274	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805767	140274	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
	46931421	176263	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4476670	176263	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4594971	176263	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	468	9	2	7	3.6	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3s2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	126495424	140255	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1cccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)c1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805554	140255	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	389	5	2	6	3.4	Cc1cccc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)c1	10.1021/acsmedchemlett.5b00455
	127052615	140270	0	None	181	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	401	6	2	6	3.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805693	140270	0	None	181	3	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	401	6	2	6	3.7	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127027875	139416	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1016/j.bmcl.2016.03.110
	CHEMBL3793786	139416	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1016/j.bmcl.2016.03.110
	127026954	139420	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	457	5	2	6	4.5	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1C(F)(F)F	10.1016/j.bmcl.2016.03.110
	CHEMBL3793809	139420	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	457	5	2	6	4.5	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)ccc1C(F)(F)F	10.1016/j.bmcl.2016.03.110
	127027875	139416	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3793786	139416	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	127052614	140226	0	None	40	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	415	7	2	6	4.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805176	140226	0	None	40	6	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	415	7	2	6	4.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/CCOc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	118517490	153155	0	None	-12	4	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	CHEMBL3976710	153155	0	None	-12	4	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
	44230723	176505	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4473407	176505	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596867	176505	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	490	10	2	8	2.8	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccnnc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	134155748	151169	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	151169	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	145965248	164230	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	439	10	2	6	5.4	CC(C)(C)CC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4211120	164230	0	None	-9	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	439	10	2	6	5.4	CC(C)(C)CC[C@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	11855867	145983	0	None	10	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3918349	145983	0	None	10	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	58681361	144681	0	None	-33	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	318	8	2	3	3.5	Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3908432	144681	0	None	-33	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	318	8	2	3	3.5	Cc1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44304181	203273	0	None	-1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64663	203273	0	None	-1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	58932683	75287	0	None	-1995	2	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	CHEMBL2037289	75287	0	None	-1995	2	Rat	5.5	pEC50	=	5.5	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
	11955178	153787	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3982222	153787	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	448	11	3	3	6.0	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	44303980	168074	0	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse EP2- receptorEffective concentration which increases intracellular c-AMP production in mouse EP2- receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL432522	168074	0	None	1	2	Mouse	7.5	pEC50	=	7.5	Functional	Effective concentration which increases intracellular c-AMP production in mouse EP2- receptorEffective concentration which increases intracellular c-AMP production in mouse EP2- receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
	1883	3082	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	3082	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	3082	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	3082	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	3082	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	3082	75	None	-6	12	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISAAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in intracellular cAMP level incubated for 30 mins by ELISA	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	17757350	152754	0	None	870	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	152754	0	None	870	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	89444121	147432	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	CHEMBL3929987	147432	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	45271237	195099	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549870	195099	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	66858036	163891	0	None	-93	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	468	10	2	7	4.8	C[C@@H]1OC(=O)N(CCSc2nc(C(=O)O)cs2)[C@H]1/C=C/CC(C)(O)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4207054	163891	0	None	-93	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	468	10	2	7	4.8	C[C@@H]1OC(=O)N(CCSc2nc(C(=O)O)cs2)[C@H]1/C=C/CC(C)(O)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	59465599	146561	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	12	2	3	6.2	CCCC1(C(O)c2cccc([C@H]3CCC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3922856	146561	0	None	1	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	12	2	3	6.2	CCCC1(C(O)c2cccc([C@H]3CCC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	59465600	151698	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3964261	151698	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	58681358	150659	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	420	10	2	2	6.3	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(CC3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3955642	150659	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	420	10	2	2	6.3	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(CC3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44442331	94490	0	None	-346	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	CHEMBL251505	94490	0	None	-346	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulationAgonist activity at EP2 receptor expressed in HEK293 cells assessed as cAMP accumulation	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
	44230430	176370	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4449902	176370	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595790	176370	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	506	10	2	6	4.2	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(F)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	71515518	142806	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3892911	142806	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	89443584	145177	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3912323	145177	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2C)c(F)c(-c2cccc(F)c2)c1	nan
	118517361	153370	0	None	-107	3	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	CHEMBL3978590	153370	0	None	-107	3	Human	7.5	pEC50	=	7.5	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
	155542681	176600	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4521659	176600	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597685	176600	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	7	3.7	CC(C)(C)c1ccc(CN(Cc2csc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	11955156	148454	1	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	3	4	4.9	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	CHEMBL3937945	148454	1	None	-2	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	11	3	4	4.9	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3C/C=C\CCCC(=O)O)c2)CCC1	nan
	118689427	151852	0	None	-8	2	Human	7.4	pEC50	=	7.4	Functional	cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	CHEMBL3965497	151852	0	None	-8	2	Human	7.4	pEC50	=	7.4	Functional	cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.cAMP Assay: EP4 receptors couple to Gs and mediate elevations in cAMP concentration, although they do participate in other pathways as well. There are some redundancies in function between EP2 and EP4 receptors. For example, both receptors induce PGE2-mediated RANKL through cAMP.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
	57893982	75164	0	None	-25	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036318	75164	0	None	-25	2	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	11955259	146759	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	9	3	4	4.4	O=C(O)COC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3924405	146759	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	436	9	3	4	4.4	O=C(O)COC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	57529188	147195	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	147195	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	57529188	147195	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3928130	147195	0	None	19	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	44303626	168182	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL433249	168182	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	56839344	152051	0	None	-12882	8	Human	5.4	pEC50	=	5.4	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	656	13	2	9	5.1	O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3967284	152051	0	None	-12882	8	Human	5.4	pEC50	=	5.4	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	656	13	2	9	5.1	O=C(CCc1cc2c(cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC3CCCCC3)co1)OCO2)NS(=O)(=O)C(F)(F)F	nan
	11955196	144422	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	9	3	3	5.6	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3906280	144422	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	434	9	3	3	5.6	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(O)C3CCCCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44444722	94256	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	CHEMBL250153	94256	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
	17751059	148268	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3936540	148268	0	None	3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	17757350	152754	0	None	870	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	CHEMBL3973347	152754	0	None	870	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
	89444221	144280	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	430	8	3	4	3.9	NC(=O)c1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3904996	144280	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	430	8	3	4	3.9	NC(=O)c1cc(CNc2c(F)ccc(OCC(=O)O)c2F)cc(-c2cccc(F)c2)c1	nan
	53259981	176350	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4456588	176350	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595646	176350	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	467	9	2	5	4.3	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.8b00808
	53259984	176535	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4447271	176535	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597100	176535	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccc(Cl)cc2)cc1	10.1021/acs.jmedchem.8b00808
	53260154	171131	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	11	2	6	3.8	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4458330	171131	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	480	11	2	6	3.8	CCC1(c2ccc(CN(Cc3cccc(NCC(=O)O)n3)S(=O)(=O)c3cccnc3)cc2)CC1	10.1021/acs.jmedchem.8b00808
	11955276	150751	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	CHEMBL3956391	150751	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
	22246893	195952	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559561	195952	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855588	147357	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	147357	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	11855588	147357	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	147357	0	None	12	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	22246765	195198	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL550619	195198	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	22246895	195564	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL554823	195564	0	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855866	144602	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144602	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855866	144602	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3907809	144602	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	57564500	151210	0	None	2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	151210	0	None	2	3	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44230997	170537	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	479	10	2	9	1.9	O=C(O)CNc1cccc(CN(Cc2ccc(-n3cncn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4449855	170537	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	479	10	2	9	1.9	O=C(O)CNc1cccc(CN(Cc2ccc(-n3cncn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	44304199	100817	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL293242	100817	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	9821171	97866	0	None	-14454	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL272276	97866	0	None	-14454	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
	10223499	196341	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562411	196341	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	11855324	142605	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142605	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855324	142605	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3891401	142605	0	None	14	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	53259982	176435	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4561017	176435	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596258	176435	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2ccccc2F)cc1	10.1021/acs.jmedchem.8b00808
	89443872	145841	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	437	7	2	3	6.0	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	CHEMBL3917219	145841	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	437	7	2	3	6.0	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1Cl	nan
	44304124	102623	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL304225	102623	0	None	-	1	Mouse	7.4	pEC50	=	7.4	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	11955297	149887	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	416	10	3	4	4.8	O=C(O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	CHEMBL3949225	149887	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	416	10	3	4	4.8	O=C(O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(O)C2CCCCC2)cc1	nan
	22246983	195862	0	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL558671	195862	0	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
	23729077	78218	31	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	520	11	0	8	4.0	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)c1	nan
	CHEMBL2105692	78218	31	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	520	11	0	8	4.0	CC(C)OC(=O)COc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)c1	nan
	57894063	75165	0	None	-301	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	CHEMBL2036319	75165	0	None	-301	2	Rat	5.3	pEC50	=	5.3	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
	156010583	177078	0	None	-162	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	451	10	2	4	5.4	CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	CHEMBL4633041	177078	0	None	-162	2	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assayAgonist activity at human EP2 receptor expressed in HEK293 cells by calcium-5 dye based FLIPR assay	ChEMBL	451	10	2	4	5.4	CCCCCC(C)(O)/C=C/c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2020.127104
	45271238	195641	0	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL556333	195641	0	None	-	1	Rat	7.3	pEC50	=	7.3	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	59465587	145190	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	CHEMBL3912391	145190	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
	11955315	143791	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	CC(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3901088	143791	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	CC(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	11955256	143316	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	424	9	2	4	5.4	COC(=O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C(C)(C)C)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3897181	143316	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	424	9	2	4	5.4	COC(=O)CCCCCC[C@@H]1[C@@H](c2ccc(C(O)C(C)(C)C)cc2)[C@H](O)C[C@H]1Cl	nan
	16725337	149601	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149601	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	16725337	149601	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3947001	149601	0	None	4	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
	89443809	148145	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	427	8	2	4	5.3	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	CHEMBL3935521	148145	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	427	8	2	4	5.3	COc1c(C)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	89443631	148665	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	CHEMBL3939716	148665	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	415	7	2	3	5.5	Cc1c(F)cc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1C	nan
	127050450	140300	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3806076	140300	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	57395059	69474	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL1933725	69474	0	None	-11	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1021/acsmedchemlett.5b00455
	44229605	176654	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4470479	176654	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598070	176654	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	452	9	2	7	3.1	O=C(O)CNc1cccc(CN(Cc2cc3ccccc3o2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	89443989	148668	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(OCC(=O)O)c(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3939740	148668	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(OCC(=O)O)c(F)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	44444714	94138	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249341	94138	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	59465588	143526	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3898887	143526	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465575	145067	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	CHEMBL3911438	145067	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
	59465595	145423	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	CHEMBL3914108	145423	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
	59465592	149702	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3947785	149702	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
	59465590	150945	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	CHEMBL3957958	150945	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
	59465584	151430	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	CHEMBL3961847	151430	0	None	-	1	Human	4.3	pEC50	=	4.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
	11855325	144691	0	None	19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3908484	144691	0	None	19	3	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11955233	145593	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	8	3	3	4.3	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3915426	145593	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	392	8	3	3	4.3	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	11855593	146834	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	CHEMBL3924987	146834	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
	89444078	146074	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(F)cc(-c3cccc(F)c3)c2)c1F	nan
	CHEMBL3919144	146074	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	405	7	2	3	5.0	O=C(O)COc1ccc(F)c(NCc2cc(F)cc(-c3cccc(F)c3)c2)c1F	nan
	11955406	146104	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3919393	146104	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
	11955294	144768	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3909111	144768	0	None	1	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
	44303889	203217	0	None	-	1	Mouse	7.3	pEC50	=	7.3	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL64423	203217	0	None	-	1	Mouse	7.3	pEC50	=	7.3	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
	11955179	146482	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	450	12	3	3	6.2	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3922332	146482	0	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	450	12	3	3	6.2	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	11855588	147357	0	None	12	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3929446	147357	0	None	12	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
	126495432	139324	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4coc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	CHEMBL3792668	139324	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assayAgonist activity at human EP2 receptor expressed in CHO cells assessed as cAMP level by HTRF assay	ChEMBL	406	5	2	5	4.2	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4coc(C(=O)O)c4)CC[C@@H]32)ccc1Cl	10.1016/j.bmcl.2016.03.110
	71515517	148082	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1	nan
	CHEMBL3934986	148082	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	419	7	2	3	5.3	Cc1cc(CNc2c(F)ccc(OCC(=O)O)c2F)c(F)c(-c2cccc(F)c2)c1	nan
	56839343	144279	0	None	-147	6	Human	5.3	pEC50	=	5.3	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	642	14	2	8	5.4	COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1	nan
	CHEMBL3904989	144279	0	None	-147	6	Human	5.3	pEC50	=	5.3	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	642	14	2	8	5.4	COc1ccc(CCC(=O)NS(=O)(=O)C(F)(F)F)c(CN2CCC[C@H]2c2nc(C(=O)NCCCCC3CCCCC3)co2)c1	nan
	45266955	195645	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	CHEMBL556416	195645	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
	57564500	151210	0	None	2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959926	151210	0	None	2	3	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	44303723	202935	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL62885	202935	0	None	-	1	Mouse	6.2	pEC50	=	6.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
	45269576	195983	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL559820	195983	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	9863804	94098	0	None	-120	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	CHEMBL249136	94098	0	None	-120	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human prostaglandin EP2 receptorAgonist activity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
	89444271	151908	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C	nan
	CHEMBL3966050	151908	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	411	7	2	3	5.6	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2C)c1C	nan
	53259983	176301	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4587628	176301	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595199	176301	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	485	9	2	5	4.4	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(F)c2)cc1	10.1021/acs.jmedchem.8b00808
	2720	3854	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	5820	3854	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	6918140	3854	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	CHEMBL1237119	3854	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	DB00374	3854	59	None	-10	5	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysisAgonist activity at human EP2 expressed in HEK293 cells assessed as increase in cAMP level incubated for 20 mins measured after 60 mins addition of cAMP detect reagent by HTRF analysis	ChEMBL	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	10.1016/j.ejmech.2022.114154
	127052577	140260	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(Cl)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805596	140260	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(Cl)c3)O2)n1	10.1021/acsmedchemlett.5b00455
	67082722	164628	0	None	2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	CHEMBL4216182	164628	0	None	2	3	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	425	12	2	6	5.2	CCCCC[C@@](C)(O)C/C=C/[C@H]1CCC(=O)[C@@H]1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2017.11.035
	8541	2944	2	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	9824353	2944	2	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL292964	2944	2	None	-66069	4	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	155527947	176534	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4460294	176534	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4597099	176534	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	501	9	2	5	4.9	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccc(Cl)c2)cc1	10.1021/acs.jmedchem.8b00808
	11955157	152643	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	430	12	3	4	5.1	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	CHEMBL3972401	152643	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	430	12	3	4	5.1	CCCC1(C(O)c2cccc([C@H]3[C@H](O)CC(=O)[C@@H]3CCCCCCC(=O)O)c2)CCC1	nan
	56649302	152666	0	None	-169	6	Human	5.2	pEC50	=	5.2	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	630	13	2	7	5.5	O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3972583	152666	0	None	-169	6	Human	5.2	pEC50	=	5.2	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	630	13	2	7	5.5	O=C(CCc1ccc(F)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	155539238	176481	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4514124	176481	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596631	176481	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	474	9	2	6	4.0	CC(C)(C)C1CCC(CN(Cc2cccc(NCC(=O)O)n2)S(=O)(=O)c2cccnc2)CC1	10.1021/acs.jmedchem.8b00808
	71516449	149436	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	CHEMBL3945923	149436	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(-c2cccc(F)c2)cc1CNc1c(F)ccc(OCC(=O)O)c1F	nan
	127050766	140213	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805075	140213	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	393	5	2	6	3.3	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
	89443614	150589	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	393	7	2	3	5.5	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3955120	150589	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	393	7	2	3	5.5	Cc1cc(CNc2c(C)ccc(OCC(=O)O)c2C)cc(-c2cccc(F)c2)c1	nan
	127052613	140206	0	None	-10	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	7	3	7	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	CHEMBL3804978	140206	0	None	-10	6	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	431	7	3	7	3.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3/C=C/[C@@H](O)COc3ccccc3)O2)n1	10.1021/acsmedchemlett.5b00455
	11955236	146456	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	CHEMBL3922121	146456	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
	44303711	102352	0	None	-	1	Mouse	7.2	pEC50	=	7.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	CHEMBL303763	102352	0	None	-	1	Mouse	7.2	pEC50	=	7.2	Functional	Effective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptorEffective concentration which increases intracellular c-AMP production in mouse Prostanoid EP2 receptor	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
	67245477	144883	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	CHEMBL3909989	144883	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
	24760055	143888	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143888	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	24760055	143888	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	CHEMBL3901873	143888	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
	89443736	151354	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	CHEMBL3961188	151354	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	421	7	2	3	5.5	O=C(O)COc1ccc(Cl)c(NCc2cc(-c3cccc(F)c3)ccc2F)c1F	nan
	12521	2197	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	72722131	2197	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	CHEMBL3918816	2197	0	None	-23988	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
	11955234	152217	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3968751	152217	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	394	9	3	3	4.6	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc(C3(O)CCC3)cc2)[C@H](O)C[C@H]1Cl	nan
	44230431	176653	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4531171	176653	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	CHEMBL4598069	176653	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	522	10	2	6	4.7	O=C(O)CNc1cccc(CN(Cc2ccc(-c3ccc(Cl)cc3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
	118517483	144271	0	None	-22	3	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	144271	0	None	-22	3	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	11855590	144374	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	144374	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	11855590	144374	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	CHEMBL3905811	144374	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
	134147021	150024	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	CHEMBL3950412	150024	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
	11955255	146257	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3920560	146257	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	92135977	152896	0	None	-141	4	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	CHEMBL3974652	152896	0	None	-141	4	Human	7.1	pEC50	=	7.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
	5819	1012	29	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	673766	1012	29	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	CHEMBL1578948	1012	29	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at EP2 receptor (unknown origin) by cAMP assayAgonist activity at EP2 receptor (unknown origin) by cAMP assay	ChEMBL	333	4	1	5	4.0	CCOC(=O)c1c(sc2c1CCCCC2)NC(=O)c1ccco1	10.1021/jm401431x
	11855871	146408	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3921784	146408	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11855594	152980	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3975238	152980	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	142793	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142793	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	11502897	142793	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	CHEMBL3892847	142793	0	None	43	3	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assayAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of calcium mobilization after 45 mins by fluo-4AM dye-based FLIPR assay	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
	89443779	148739	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	399	7	3	4	4.7	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	CHEMBL3940318	148739	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	399	7	3	4	4.7	Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(O)cc(-c2cccc(F)c2)c1	nan
	89443711	150979	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2cc(F)cc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	CHEMBL3958279	150979	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	433	7	2	3	5.6	Cc1cc(-c2cc(F)cc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1C	nan
	118517483	144271	0	None	-22	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	CHEMBL3904946	144271	0	None	-22	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
	118517359	144396	0	None	-79	4	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	CHEMBL3906016	144396	0	None	-79	4	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
	118517488	153711	0	None	-14	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	CHEMBL3981554	153711	0	None	-14	3	Human	8.1	pEC50	=	8.1	Functional	cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.cAMP Assay: A 384-well drug plate was prepared to contain test compounds, PGE2 and cAMP in 16 serial dilutions in triplicate, using a Biomek station. HEK-EBNA cells expressing a target PG receptor subtype (EP2 or EP4) were suspended in a stimulation buffer (HBSS, 0.1% BSA, 0.5 mM IBMX and 5 mM HEPES, pH 7.4) in a density of 104 cells/5 μl. The reaction was initiated by mixing 5 μL drug dilutions with 5 μl of HEK-EBNA cells in a well, carried out for 30 min at room temperature, and followed by the addition of 5 μl anti-cAMP acceptor beads in the control buffer with Tween-20 (25 mM NaCl, 0.03% Tween-20, 5 mM HEPES, pH7.4). After 30 min in the dark at room temperature, the mixtures were incubated with 15 μl biotinylated-cAMP/strpavidin donor beads in Lysis/Detection buffer (0.1% BSA, 0.3% Tween-20 and 5 mM HEPES, pH7.4) for 45 min at the room temperature. Fluorescence changes were read using a Fusion-alpha HT microplate reader.	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
	44442327	94459	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	CHEMBL251294	94459	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human EP2 receptor by cAMP assayAgonist activity at human EP2 receptor by cAMP assay	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
	11955358	153082	0	None	-11	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	CHEMBL3976116	153082	0	None	-11	3	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
	155521507	176449	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4451941	176449	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4596396	176449	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	482	10	2	6	4.1	CC(C)(C)c1ccc(CN(Cc2cccc(NCCC(=O)O)n2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
	56839342	149007	0	None	-83	7	Human	6.1	pEC50	=	6.1	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	646	13	2	7	6.0	O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	CHEMBL3942394	149007	0	None	-83	7	Human	6.1	pEC50	=	6.1	Functional	Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.Cell Based Assay: Ca2+ signaling studies were performed using a FLIPR TETRA system (Molecular Devices, Sunnyvale, Calif., USA) in the 384-format. This is a high-throughput instrument for cell-based assays to monitor Ca2+ signaling associated with GPCRs and ion channels. Cells were seeded at a density of 5×104 cells/well in BioCoat poly-D-lysine coated, black wall, clear bottom 384-well plates (BD Biosciences, Franklin lakes, NJ, USA) and allowed to attach overnight in an incubator at 37° C. The cells were then washed twice with HBSS-HEPES buffer (Hanks' balanced salt solution without bicarbonate and phenol red, 20 mM HEPES, pH 7.4) using an ELx405 Select CW Microplate Washer (BioTek, Winooski, Vt., USA). After 60 min of dye-loading in the dark using the Ca2+-sensitive dye Fluo-4AM (Invitrogen, Carlsbad, Calif., USA), at a final concentration of 2×10^−6M, the plates were washed 4 times with HBSS-HEPES buffer to remove excess dye and leaving 50 μl of buffer in each well. The plates were then placed in the FLIPR TETRA instrument and allowed to equilibrate at 37° C. AGN-211377 was added in a 25 μl volume to each well to give final concentrations of 0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM, and 30 μM; or 0.067 μM, 0.1 μM, 0.2 μM, 0.3 μM, 0.67 μM, and 1 μM for cells over-expressing TP receptors. After 4.5 minutes, a 7-point serial dilution of the standard agonist for the corresponding receptor, in a 25 μl volume was injected at the final concentrations from 10^−11M to 10^−5M in 10-fold serial dilution increments for cells expressing human recombinant DP1, EP1, EP2, EP3, EP4, FP, and IP receptors. The dose range for the standard agonist for human recombinant TP receptors was from 10^−12M to 10^−6M. HBSS-HEPES buffer was used as the negative control for the standard agonists. Cells were excited with LED (light emitting diode) excitation at 470-495 nm and emission was measured through an emission filter at 515-575 nm. Assay plates were read for 3.5 minutes using the FLIPRTETRA.	ChEMBL	646	13	2	7	6.0	O=C(CCc1ccc(Cl)cc1CN1CCC[C@H]1c1nc(C(=O)NCCCCC2CCCCC2)co1)NS(=O)(=O)C(F)(F)F	nan
	58932678	75288	0	None	-301	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	CHEMBL2037290	75288	0	None	-301	2	Rat	5.1	pEC50	=	5.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
	22246956	196319	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL562291	196319	0	None	-	1	Rat	6.1	pEC50	=	6.1	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	69753740	140222	0	None	-2454	5	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	390	9	3	5	2.8	O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1	10.1021/acsmedchemlett.5b00455
	CHEMBL3805134	140222	0	None	-2454	5	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF methodAgonist activity at human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level after 30 mins by HTRF method	ChEMBL	390	9	3	5	2.8	O=C(O)CCC[C@H]1CC[C@H]2[C@H](C[C@@H](O)[C@@H]2/C=C/[C@@H](O)COc2ccccc2)O1	10.1021/acsmedchemlett.5b00455
	134155748	151169	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	CHEMBL3959653	151169	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assayAgonist activity at human recombinant EP2 receptor expressed in HEK-EBNA cells incubated for 30 mins by cAMP accumulation assay	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
	89443669	147212	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	7	3	4	4.9	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1O	nan
	CHEMBL3928263	147212	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	417	7	3	4	4.9	Cc1cc(-c2cccc(F)c2)cc(CNc2c(F)ccc(OCC(=O)O)c2F)c1O	nan
	89443662	152888	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3974557	152888	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	412	7	2	4	4.7	N#Cc1c(OCC(=O)O)ccc(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	1883	3082	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	1916	3082	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	5280360	3082	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	913	3082	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	CHEMBL548	3082	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	DB00917	3082	75	None	-6	12	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assayAgonist activity at human EP2 receptor expressed in HEK293T/17 cells assessed as increase in GalphaS-mediated CREB activation measured after 6 to 24 hrs by SEAP reporter gene-based chemiluminescence assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
	56835070	69471	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	CHEMBL1933722	69471	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptorAgonist activity at rat EP2 receptor	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
	56835070	69471	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	CHEMBL1933722	69471	0	None	-112	2	Rat	7.1	pEC50	=	7.1	Functional	Agonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassayAgonist activity at rat EP2 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
	51036042	176341	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4554216	176341	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	CHEMBL4595541	176341	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 minsAgonist activity at recombinant human EP2 receptor expressed in HEK293 cells assessed as induction of cAMP accumulation after 30 mins	ChEMBL	405	8	2	5	2.8	CC(C)(C)c1ccc(CN(Cc2cccc(NCC(=O)O)n2)S(C)(=O)=O)cc1	10.1021/acs.jmedchem.8b00808
	66857975	164488	0	None	-10	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	454	10	2	7	4.4	CC(O)(C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	CHEMBL4214346	164488	0	None	-10	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIAAgonist activity at recombinant human EP2 receptor expressed in CHO cells assessed as increase in intracellular cAMP level by EIA	ChEMBL	454	10	2	7	4.4	CC(O)(C/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1)CC1CCCCC1	10.1016/j.bmc.2017.11.035
	11955133	145649	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	374	8	1	4	4.5	COC(=O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(C)(C)C)cc1	nan
	CHEMBL3915820	145649	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assayAgonist activity at human recombinant EP2 receptor expressed in HEK293 cells assessed as effect on calcium accumulation by Fluo-4 AM dye based FLIPR assay	ChEMBL	374	8	1	4	4.5	COC(=O)CCCCCC[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc(C(C)(C)C)cc1	nan
	9820676	195045	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	CHEMBL549461	195045	0	None	-	1	Rat	7.0	pEC50	=	7.0	Functional	Agonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP releaseAgonist activity against rat EP2 receptor expressed in HEK293 cells assessed as stimulation of cAMP release	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
	89444029	149094	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	CHEMBL3943109	149094	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.Cellular Functional Assay: Human CHO cells expressing the recombinant human prostanoid EP2 receptor were suspended in assay medium (HBSS buffer (Invitrogen) containing 20 mM HEPES (pH7.4) and 500 μM isobutyl-methylxanthine IBMX) and plated out to yield approximately 1×104 cells/well in a 96-well. Following this, cells were incubated with agonists for 30 min in the presence of the test compounds. For stimulated control measurements, separate assay wells contain 10 μM PGE2 (control specific agonist). All incubations were carried out at 37° C. in a 5% CO2 atmosphere. Following incubation, the amount of cAMP in each well was determined by HTRF method. The cells are lysed and the fluorescence acceptor (D2-labeled cAMP) and fluorescence donor (anti-cAMP antibody labeled with europium cryptate) are added.	ChEMBL	401	7	2	3	5.2	Cc1ccc(OCC(=O)O)c(F)c1NCc1cc(-c2cccc(F)c2)ccc1F	nan
	122180297	121647	0	None	4466	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586362	121647	0	None	4466	2	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180261	121613	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586324	121613	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
	122180274	121623	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586337	121623	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180288	121638	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586352	121638	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180250	121602	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586313	121602	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
	122180267	121617	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586330	121617	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180251	121603	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586314	121603	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
	122180273	121622	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586336	121622	0	None	-	1	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	1987175	3794	31	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	9283	3794	31	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	CHEMBL1372836	3794	31	None	1	5	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assayAntagonist activity at human EP2 receptor overexpressed in rat C6 cells assessed as inhibition of PGE2-induced cAMP accumulation incubated for 10 mins prior to PGE2 addition measured after 40 mins by TR-FRET assay	ChEMBL	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	10.1021/ml400112h
	122180270	121619	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586333	121619	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180282	121631	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586345	121631	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180295	121644	0	None	281	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586359	121644	0	None	281	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180296	121646	0	None	758	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586361	121646	0	None	758	2	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
	122180265	121616	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586328	121616	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180276	121625	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586339	121625	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180289	121639	0	None	7	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586353	121639	0	None	7	2	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121645	0	None	-2	4	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121645	0	None	-2	4	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	30897313	121598	0	None	-2	5	Rat	6.5	pIC50	=	6.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121598	0	None	-2	5	Rat	6.5	pIC50	=	6.5	Functional	Antagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at rat EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	42484632	121599	5	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586310	121599	5	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
	122180275	121624	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586338	121624	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180278	121627	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586341	121627	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180286	121635	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586349	121635	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121645	0	None	2	4	Mouse	8.4	pIC50	=	8.4	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121645	0	None	2	4	Mouse	8.4	pIC50	=	8.4	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180283	121632	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586346	121632	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180280	121629	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586343	121629	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180263	121614	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586326	121614	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	56927669	121645	0	None	-3	4	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	CHEMBL3586360	121645	0	None	-3	4	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
	122180252	121604	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586315	121604	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
	122180284	121633	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586347	121633	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121598	0	None	2	5	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121598	0	None	2	5	Mouse	7.2	pIC50	=	7.2	Functional	Antagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at mouse EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	30897313	121598	0	None	-2	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586309	121598	0	None	-2	5	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180272	121621	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586335	121621	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180279	121628	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586342	121628	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	122180249	121601	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586312	121601	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
	30956824	121600	4	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586311	121600	4	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
	122180277	121626	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	CHEMBL3586340	121626	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP productionAntagonist activity at human EP2 receptor overexpressed in human ECV304 cells assessed as inhibition of prostaglandin E2-induced cAMP production	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
	44365207	40696	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	489	5	2	6	3.8	O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL148449	40696	0	None	-	0	Human	6.6	pKd	=	6.6	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	489	5	2	6	3.8	O=C(CCS(=O)(=O)Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	38191	9913	16	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	407	4	2	3	4.6	O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL114395	9913	16	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	407	4	2	3	4.6	O=C(CCCCCl)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	44365227	121986	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	473	5	2	5	4.1	O=C(CC[S+]([O-])Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	CHEMBL359231	121986	0	None	-	0	Human	6.2	pKd	=	6.2	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	473	5	2	5	4.1	O=C(CC[S+]([O-])Cc1ccco1)NNC(=O)N1Cc2ccccc2Oc2ccc(Cl)cc21	10.1016/0960-894X(94)80027-8
	1924	3542	39	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	9933831	3542	39	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	CHEMBL358653	3542	39	None	-	0	Human	8.1	pKd	=	8.1	Functional	Compound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uMCompound was tested for antagonism of Prostaglandin E2 receptor activity in guinea pig ileum assay based on the dose ratio at 3 uM	ChEMBL	457	5	2	5	5.1	O=C(NNC(=O)N1Cc2ccccc2Oc2c1cc(Cl)cc2)CCSCc1ccco1	10.1016/0960-894X(94)80027-8
	119461	320	72	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	1896	320	72	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	CHEMBL1317823	320	72	None	-	0	Human	5.9	pKi	=	5.9	Functional	Antagonist activity at EP2 receptor (unknown origin) by functional cAMP assayAntagonist activity at EP2 receptor (unknown origin) by functional cAMP assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
	9817405	165403	5	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00056-7
	CHEMBL423815	165403	5	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/s0960-894x(01)00056-7
	10402929	57543	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00056-7
	CHEMBL166351	57543	0	None	-	0	Human	4.9	pKi	=	4.9	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(01)00056-7
	44377464	120085	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl	10.1016/s0960-894x(01)00056-7
	CHEMBL350832	120085	0	None	-	0	Human	5.4	pKi	=	5.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	306	4	1	1	4.7	O=C(O)/C=C/c1ccccc1Cc1ccc(Cl)cc1Cl	10.1016/s0960-894x(01)00056-7
	9817292	57227	0	None	-	0	Human	4.4	pKi	=	4.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	284	5	1	2	4.1	CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/s0960-894x(01)00056-7
	CHEMBL165010	57227	0	None	-	0	Human	4.4	pKi	=	4.4	Functional	Antagonistic activity at Prostanoid EP2 receptor in human was determinedAntagonistic activity at Prostanoid EP2 receptor in human was determined	ChEMBL	284	5	1	2	4.1	CSc1ccc(Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/s0960-894x(01)00056-7
	10483360	199228	28	None	-	4	Human	4.4	pKi	=	4.4	Functional	Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionInhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP production	ChEMBL	580	12	3	6	5.8	CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2009.09.052
	CHEMBL589973	199228	28	None	-	4	Human	4.4	pKi	=	4.4	Functional	Inhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP productionInhibition of EP2 expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP production	ChEMBL	580	12	3	6	5.8	CCCCNC(=O)c1ccc(Oc2ccc(CC(=O)O)cc2OC)c(NS(=O)(=O)c2ccc(Cl)cc2Cl)c1	10.1016/j.bmcl.2009.09.052
	138	3081	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	1882	3081	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	5280723	3081	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	CHEMBL495	3081	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	DB00770	3081	88	None	-4	10	Human	8.1	pEC50	=	8.1	Functional	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
	44230999	167446	26	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	CHEMBL4297666	167446	26	None	-	1	Human	8.1	pEC50	=	8.1	Functional	activity measured for the active metabolite (omidenepag)activity measured for the active metabolite (omidenepag)	Drug Central	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	None
	1929	1605	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	9890801	1605	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	CHEMBL563646	1605	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	DB12022	1605	55	None	2	2	Rat	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	1883	3082	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1916	3082	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	5280360	3082	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	913	3082	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	CHEMBL548	3082	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	DB00917	3082	75	None	-2	12	Rat	8.1	pIC50	=	8.1	Functional	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
	1929	1605	55	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	9890801	1605	55	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	CHEMBL563646	1605	55	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	DB12022	1605	55	None	2	2	Rat	7.3	pIC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	19250823
	18376177	3753	50	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	5816	3753	50	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	CHEMBL2107783	3753	50	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	DB12623	3753	50	None	-1	2	Human	8.0	pIC50	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	18376177	3753	50	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	5816	3753	50	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	CHEMBL2107783	3753	50	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	DB12623	3753	50	None	1	2	Rat	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	21376717
	12520	3796	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	35187419
	12520	3796	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	36654746
	155128767	3796	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	35187419
	155128767	3796	0	None	-	1	Human	7.9	pKB	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	344	5	3	2	3.8	CC1=C(CCNC(=O)C2=CC=C(C=C2)C3=CNC=N3)C4=C(N1)C=CC=C4	36654746
	10603	3792	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	145996528	3792	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	CHEMBL4552900	3792	0	None	537	3	Human	8.0	pKB	=	8.0	Functional	UnclassifiedUnclassified	Guide to Pharmacology	400	6	3	5	4.0	Cc1cc(Nc2ncc(cn2)C(=O)NCCc2c(C)[nH]c3c2cccc3)nc(c1)C	31904232
	1987175	3794	31	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	9283	3794	31	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	CHEMBL1372836	3794	31	None	1	5	Human	8.1	pKB	=	8.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	7	3	7	3.6	CCc1nnc(s1)NS(=O)(=O)c1ccc(cc1)NC(=S)NC(=O)/C=C/c1ccc(cc1)F	23914286
	25114442	3061	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	25114442	3061	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	5817	3061	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	5817	3061	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	CHEMBL3286797	3061	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	CHEMBL3286797	3061	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	DB12024	3061	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	21595651
	DB12024	3061	56	None	-1	3	Human	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	25114442	3061	56	None	1	3	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	5817	3061	56	None	1	3	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	CHEMBL3286797	3061	56	None	1	3	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	DB12024	3061	56	None	1	3	Mouse	8.3	pKB	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	22747912
	46213069	3063	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	8538	3063	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	CHEMBL5285583	3063	0	None	-	1	Human	8.5	pKB	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	23786281
	8546	3795	0	None	-	1	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	9	1	3	4.5	CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC	24937185
	91827368	3795	0	None	-	1	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	377	9	1	3	4.5	CCN(c1ccc(cc1)CC(=O)NCCCn1c(C)cc2c1cccc2)CC	24937185
	5818	3793	47	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596
	5886965	3793	47	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596
	CHEMBL1368005	3793	47	None	1096	2	Human	8.6	pKB	=	8.6	Functional	UnclassifiedUnclassified	Guide to Pharmacology	394	8	1	5	3.8	COc1cc(/C=C/C(=O)NCCn2c(C)cc3c2cccc3)cc(c1OC)OC	22323596

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		11855868	152544	0	None	-	1	Human	9.8	pEC50	=	9.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3971632	152544	0	None	-	1	Human	9.8	pEC50	=	9.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		127037150	137560	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	12	2	6	4.1	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
		CHEMBL3754586	137560	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	12	2	6	4.1	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
		16725337	149601	0	None	-	1	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3947001	149601	0	None	-	1	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		59554827	137293	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	11	2	6	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
		CHEMBL3752377	137293	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	426	11	2	6	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
		11502897	142793	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3892847	142793	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855865	153277	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3977724	153277	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855870	146280	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3920756	146280	0	None	-	1	Human	8.8	pEC50	=	8.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		1932	2942	5	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
		5311228	2942	5	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
		CHEMBL3286796	2942	5	None	1	6	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
		90054482	143917	0	None	-	0	Human	6.0	pEC50	=	6	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	463	10	2	4	4.4	C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3902065	143917	0	None	-	0	Human	6.0	pEC50	=	6	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	463	10	2	4	4.4	C[C@@H](Cc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		90054490	152190	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3968443	152190	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		127051063	140322	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
		CHEMBL3806284	140322	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3C(F)(F)F)O2)n1	10.1021/acsmedchemlett.5b00455
		11855590	144374	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3905811	144374	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	8	2	5	3.4	CC(C)C(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		90054450	143776	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	493	13	2	4	5.4	C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3900979	143776	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	493	13	2	4	5.4	C[C@@H](CCCc1ccccc1)[C@H](O)CC[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		11855591	144436	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
		CHEMBL3906402	144436	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
		72948479	153033	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3975743	153033	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		70667255	151474	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3962183	151474	0	None	-	1	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
		90054430	149364	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	505	13	2	4	5.6	C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3945327	149364	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	505	13	2	4	5.6	C[C@@H](CCCCc1ccccc1)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		5283056	202860	34	None	-	0	Human	7.8	pEC50	=	7.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	nan
		CHEMBL62570	202860	34	None	-	0	Human	7.8	pEC50	=	7.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O	nan
		66858111	137451	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	488	11	2	7	4.5	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1	10.1016/j.bmcl.2015.12.039
		CHEMBL3753622	137451	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	488	11	2	7	4.5	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCc3ccccc3)CCC2)n1	10.1016/j.bmcl.2015.12.039
		72950425	143050	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	419	8	2	3	3.5	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
		CHEMBL3895047	143050	0	None	-	1	Human	5.8	pEC50	=	5.8	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	419	8	2	3	3.5	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
		11328569	137468	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	COCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		CHEMBL3753788	137468	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	COCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		11855324	142605	0	None	-	1	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3891401	142605	0	None	-	1	Human	6.7	pEC50	=	6.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		72950929	146582	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	395	10	2	3	3.7	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
		CHEMBL3923027	146582	0	None	-	1	Human	5.7	pEC50	=	5.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	395	10	2	3	3.7	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCc1ccc(C(=O)O)cc1	nan
		1883	3082	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		1916	3082	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		5280360	3082	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		913	3082	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		CHEMBL548	3082	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		DB00917	3082	75	None	-6	24	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		126495400	139321	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
		CHEMBL3792632	139321	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(Cl)c(Cl)c3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
		127026955	139450	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
		CHEMBL3794016	139450	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	437	5	2	6	4.4	Cc1cc(OC[C@H]2[C@H](O)C[C@@H]3O[C@@H](c4nc(C(=O)O)cs4)CC[C@@H]32)cc(C)c1Cl	10.1016/j.bmcl.2016.03.110
		18376177	3753	50	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
		5816	3753	50	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
		CHEMBL2107783	3753	50	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
		DB12623	3753	50	None	-	1	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
		11294085	137252	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmcl.2015.12.039
		CHEMBL3751951	137252	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	458	12	2	7	4.0	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCCCF)CCC2)n1	10.1016/j.bmcl.2015.12.039
		59554822	137394	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	440	11	2	7	4.0	CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		CHEMBL3753221	137394	0	None	-	1	Human	8.5	pEC50	=	8.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	440	11	2	7	4.0	CCCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		127051062	140274	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
		CHEMBL3805767	140274	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	409	5	2	6	3.8	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccccc3Cl)O2)n1	10.1021/acsmedchemlett.5b00455
		72950089	150591	0	None	-1621	3	Human	6.7	pEC50	=	6.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	nan
		CHEMBL3955128	150591	0	None	-1621	3	Human	6.7	pEC50	=	6.7	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	nan
		66857670	137401	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	436	9	2	7	3.3	CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		CHEMBL3753268	137401	0	None	-	1	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	436	9	2	7	3.3	CC#CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		57529188	147195	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3928130	147195	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		11855866	144602	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3907809	144602	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855325	144691	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3908484	144691	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 6.0 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855324	142605	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3891401	142605	0	None	-	1	Human	7.6	pEC50	=	7.6	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		127026652	137482	0	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		CHEMBL3753898	137482	0	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	456	12	2	8	3.3	CCOCCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		127026956	139426	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
		CHEMBL3793862	139426	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	477	5	2	6	5.1	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cc(Cl)c(Cl)cc3Cl)O2)n1	10.1016/j.bmcl.2016.03.110
		9807448	203172	0	None	1	4	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
		CHEMBL64246	203172	0	None	1	4	Human	8.4	pEC50	=	8.4	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
		11855867	145983	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3918349	145983	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		1892	747	20	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
		25886893	747	20	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
		CHEMBL1628262	747	20	None	-2	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
		72948663	145734	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	415	11	2	4	4.1	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3916499	145734	0	None	-	1	Human	6.5	pEC50	=	6.5	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	415	11	2	4	4.1	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		5311035	97803	29	None	-4	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
		CHEMBL271896	97803	29	None	-4	9	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
		1883	3082	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
		1916	3082	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
		5280360	3082	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
		913	3082	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
		CHEMBL548	3082	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
		DB00917	3082	75	None	-6	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acsmedchemlett.5b00455
		66857738	137300	0	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	468	10	2	7	4.7	CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		CHEMBL3752435	137300	0	None	-	1	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	468	10	2	7	4.7	CC(C)(C)CCC1([C@H](O)/C=C/[C@H]2COC(=O)N2CCSc2nc(C(=O)O)cs2)CCC1	10.1016/j.bmcl.2015.12.039
		127050451	140221	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
		CHEMBL3805122	140221	0	None	-	0	Human	5.4	pEC50	=	5.4	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3ccc(OC(F)(F)F)cc3)O2)n1	10.1021/acsmedchemlett.5b00455
		1929	1605	55	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
		9890801	1605	55	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
		CHEMBL563646	1605	55	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
		DB12022	1605	55	None	-11	2	Human	8.3	pEC50	=	8.3	Binding	Agonist activity at EP2 receptor (unknown origin) by functional assayAgonist activity at EP2 receptor (unknown origin) by functional assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
		11362836	137296	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	446	12	2	7	3.8	CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
		CHEMBL3752406	137296	0	None	-	1	Human	8.2	pEC50	=	8.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	446	12	2	7	3.8	CC(C)(CCCCF)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
		11855325	144691	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3908484	144691	0	None	-	1	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855593	146834	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
		CHEMBL3924987	146834	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	425	11	2	4	4.7	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2cccc(C(=O)O)c2)cc1	nan
		11855588	147357	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL3929446	147357	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	345	8	1	2	4.9	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2CCCCCCC(=O)O)cc1	nan
		5283086	203310	24	None	-	5	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
		CHEMBL64804	203310	24	None	-	5	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
		11156167	137520	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	494	11	2	7	5.2	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1	10.1016/j.bmcl.2015.12.039
		CHEMBL3754197	137520	0	None	-	1	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	494	11	2	7	5.2	O=C(O)c1csc(SCCN2C(=O)OC[C@@H]2/C=C/[C@@H](O)C2(CCC3CCCCC3)CCC2)n1	10.1016/j.bmcl.2015.12.039
		90054537	148403	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3937596	148403	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	491	12	2	4	5.2	C[C@@H](CCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		127051656	140294	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
		CHEMBL3805981	140294	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	459	6	2	7	4.0	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(OC(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
		59554824	137475	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	428	11	2	7	3.9	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
		CHEMBL3753853	137475	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptorAgonist activity at human EP2 receptor	ChEMBL	428	11	2	7	3.9	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1COC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2015.12.039
		90054519	151986	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	477	11	2	4	4.8	C[C@@H](CCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3966743	151986	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	477	11	2	4	4.8	C[C@@H](CCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		72948294	149957	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	439	9	2	4	4.0	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3949856	149957	0	None	-	1	Human	6.1	pEC50	=	6.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	439	9	2	4	4.0	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		90054392	142918	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		CHEMBL3893847	142918	0	None	-	0	Human	4.1	pEC50	=	4.1	Binding	SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.SEAP Activity Assay: 1. Seed cells on an EP2 or EP4 STEP plate at a density of 40,000-80,000 cells/well in 200 ul of reduced serum medium containing 0.5% FBS. Place the plate in a 37° C. incubator with 5% CO2 and incubate overnight. 2. After 16-18 hours of incubation, aspirate the culture media from each well. 3. Add 200 ul of culture medium containing different concentration of test compounds to the assigned wells. For each test compound, at least 8 concentrations starting at highest 10 M and lowest 0.01 pM were tested. In addition each concentration had triplicates. A PGE2 curve (concentrations from lowest to highest, 0 pM, 0.384 pM, 1.92 pM, 9.6 pM, 48 pM, 240 pM, 1200 pM, and 6000 pM) was always run in parallel with test compounds. 4. After 6-8 hours of stimulation with test compounds and PGE2, 10 ul of culture media from each well was transferred to a corresponding well of a 96-well solid black plate. Cover the plate with the lid.	ChEMBL	519	14	2	4	6.0	C[C@@H](CCCCCc1ccccc1)[C@@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(C(=O)O)s1	nan
		11855871	146408	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3921784	146408	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855594	152980	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3975238	152980	0	None	-	1	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulationAgonist activity at recombinant human EP2 receptor expressed in HEK293-EBNA cells co-expressing Gqs5 assessed as induction of c-AMP accumulation	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		127027874	139363	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
		CHEMBL3793045	139363	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assayAgonist activity at PK2-tagged human EP2 receptor expressed in HEK293 cells assessed as induction of EA-tagged beta-arrestin recruitment incubated for 90 mins by beta-galactosidase reporter gene assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1021/acsmedchemlett.5b00455
		127027874	139363	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
		CHEMBL3793045	139363	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assayAgonist activity at human EP2 receptor expressed in HEK293 cells after 24 hrs beta-arrestin recruitment assay	ChEMBL	443	5	2	6	4.2	O=C(O)c1csc([C@H]2CC[C@H]3[C@H](C[C@@H](O)[C@@H]3COc3cccc(C(F)(F)F)c3)O2)n1	10.1016/j.bmcl.2016.03.110
		10339756	143085	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
		CHEMBL3895324	143085	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
		118689427	151852	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
		CHEMBL3965497	151852	0	None	-	0	Human	7.0	pEC50	=	7.0	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10N HCl is added to achieve a pH of 7.4). The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 °C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H−] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations were for 60 min at 25 °C. and were terminated by the addition of 4 ml of ice-cold 50 mM TRIS-HCl, followed by rapid filtration through Whatman GF/B filters and three additional 4 ml washes in a cell harvester (Brandel). Competition studies were performed using a final concentration of 5 nM [3H]-PGE2, or 5 nM [3H] 17-phenyl PGF2a and non-specific binding determined with 10^−5M of unlabeled PGE2, or 17-phenyl PGF2a, according to receptor subtype studied.	ChEMBL	519	10	2	6	3.8	O=C(O)c1ccc(CCCN2[C@@H](/C=C/C(O)Cc3cccc(OC(F)(F)F)c3)CCS2(=O)=O)s1	nan
		56927669	121645	0	None	-	0	Mouse	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586360	121645	0	None	-	0	Mouse	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
		56927669	121645	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586360	121645	0	None	-	0	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
		10315	2926	28	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
		44230575	2926	28	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
		CHEMBL3707245	2926	28	None	-	1	Human	8.0	pIC50	=	8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/acs.jmedchem.8b00808
		122180251	121603	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586314	121603	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cn1	10.1021/acs.jmedchem.5b00567
		122180259	121611	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	479	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586322	121611	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	479	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(S(C)(=O)=O)cc1)C2	10.1021/acs.jmedchem.5b00567
		122180261	121613	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586324	121613	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(C#N)c1)C2	10.1021/acs.jmedchem.5b00567
		122180282	121631	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586345	121631	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	410	4	0	6	4.3	COc1cc(-n2ccc3cc(C#N)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		30897313	121598	0	None	-	0	Mouse	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586309	121598	0	None	-	0	Mouse	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from mouse EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		30897313	121598	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586309	121598	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from rat EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180253	121605	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	401	4	0	4	6.0	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586316	121605	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	401	4	0	4	6.0	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccc1)C2	10.1021/acs.jmedchem.5b00567
		122180271	121620	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccc(Cl)cc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586334	121620	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccc(Cl)cc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		44564990	192650	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	538	6	1	5	5.7	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21	10.1016/j.bmcl.2008.12.112
		CHEMBL521777	192650	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	538	6	1	5	5.7	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(F)c3)cccc21	10.1016/j.bmcl.2008.12.112
		122180276	121625	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586339	121625	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	399	4	0	5	4.6	COc1cc(-c2cn(C)c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180285	121634	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	372	3	0	4	5.4	c1cncc(CN2CCOc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586348	121634	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	372	3	0	4	5.4	c1cncc(CN2CCOc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
		44409693	166098	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	429	11	2	4	4.3	CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)cc1	10.1016/j.bmcl.2006.01.018
		CHEMBL425950	166098	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	429	11	2	4	4.3	CCc1ccc(CC(O)CC[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)cc1	10.1016/j.bmcl.2006.01.018
		122180269	121618	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccccc2Cl)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586332	121618	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2ccccc2Cl)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		44409907	77050	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2ccc(F)cc2)s1	10.1016/j.bmcl.2006.01.018
		CHEMBL207237	77050	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2ccc(F)cc2)s1	10.1016/j.bmcl.2006.01.018
		44570000	178650	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	544	7	2	5	6.2	O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
		CHEMBL467632	178650	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	544	7	2	5	6.2	O=C(COc1cccc2[nH]cc(Cc3ccc4ccccc4c3)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
		44409739	139660	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2-c2ccccc2)s1	10.1016/j.bmcl.2006.01.018
		CHEMBL379785	139660	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2-c2ccccc2)s1	10.1016/j.bmcl.2006.01.018
		44157014	192617	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	518	6	1	5	5.9	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21	10.1016/j.bmcl.2008.12.112
		CHEMBL521609	192617	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	518	6	1	5	5.9	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc4ccccc4c3)cccc21	10.1016/j.bmcl.2008.12.112
		58905349	156278	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	400	6	2	4	4.3	O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
		CHEMBL4065183	156278	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	400	6	2	4	4.3	O=C(O)c1ccc(CNC(=O)c2cc(Cl)cnc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
		CHEMBL4552554	214001	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000342a PTGER2	ChEMBL		None	None	None		O=C(c1ccc(F)cc1)N1CC(COc2ccc(Br)cc2)(C(=O)O)C1	10.6019/CHEMBL5210307
		10047541	132510	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	416	13	4	6	3.8	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1	10.1021/jm990542v
		CHEMBL369797	132510	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	416	13	4	6	3.8	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccs1	10.1021/jm990542v
		122180293	121643	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	4	0	5	4.9	COc1cc(-c2csc3ccccc23)cc2c1OCC(=O)N(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586357	121643	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	4	0	5	4.9	COc1cc(-c2csc3ccccc23)cc2c1OCC(=O)N(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		11955294	144768	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
		CHEMBL3909111	144768	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	380	8	3	3	4.2	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3O)[C@H](O)C[C@H]1Cl	nan
		11955240	147990	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	352	8	3	3	3.5	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(CO)cc2)[C@H](O)C[C@H]1Cl	nan
		CHEMBL3934202	147990	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	352	8	3	3	3.5	O=C(O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(CO)cc2)[C@H](O)C[C@H]1Cl	nan
		44409910	140909	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1	10.1016/j.bmcl.2006.01.018
		CHEMBL382197	140909	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	477	11	2	4	5.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(-c3ccccc3)c2)s1	10.1016/j.bmcl.2006.01.018
		25195248	182935	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	540	6	1	4	4.6	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
		CHEMBL479263	182935	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	540	6	1	4	4.6	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3cc(F)c(F)cc3F)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
		118756024	121637	4	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	5	0	5	5.8	CCOc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586350	121637	4	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	416	5	0	5	5.8	CCOc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180286	121635	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586349	121635	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	388	3	1	5	5.1	Oc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		10339756	143085	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
		CHEMBL3895324	143085	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.Radioligand Binding: HEK-293 cells stably expressing the human or feline FP receptor, or EP1, EP2, EP3, or EP4 receptors were washed with TME buffer, scraped from the bottom of the flasks, and homogenized for 30 sec using a Brinkman PT 10/35 polytron. TME buffer was added to achieve a final 40 ml volume in the centrifuge tubes (the composition of TME is 100 mM TRIS base, 20 mM MgCl2, 2M EDTA; 10 N HCl is added to achieve a pH of 7.4).The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4 C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2 (5 nM) were performed in a 100 ul volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell.	ChEMBL	380	12	3	4	3.9	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C(C)(C)C(=O)[C@@H]1C/C=C\CCCC(=O)O	nan
		122180264	121615	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	346	4	0	4	4.2	COc1cc(-c2ccccc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586327	121615	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	346	4	0	4	4.2	COc1cc(-c2ccccc2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180267	121617	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586330	121617	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	360	4	0	4	4.5	COc1cc(-c2cccc(C)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		11955255	146257	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		CHEMBL3920560	146257	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	8	3	3	5.0	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		11495634	14905	13	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
		CHEMBL1207972	14905	13	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
		CHEMBL467114	14905	13	None	-	4	Human	5.8	pIC50	=	5.8	Binding	Inhibition of EP2 receptorInhibition of EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2009.02.112
		9820676	195045	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL549461	195045	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	13	1	3	3.8	CCCCc1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		122180290	121640	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	370	3	0	3	5.9	c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586354	121640	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	370	3	0	3	5.9	c1cncc(CN2CCCc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
		11575201	157422	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		CHEMBL4078648	157422	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	C[C@H](NC(=O)c1cc(Cl)ccc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		72695027	106266	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
		CHEMBL3115074	106266	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
		CHEMBL3138992	106266	0	None	-28	2	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
		122180256	121608	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	431	5	0	5	6.0	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586319	121608	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	431	5	0	5	6.0	COc1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
		11955406	146104	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL3919393	146104	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	376	10	3	4	3.4	CC(C)(CO)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
		44409738	139606	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmcl.2006.01.018
		CHEMBL379746	139606	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmcl.2006.01.018
		11577792	159318	19	None	-1819	5	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		CHEMBL4099851	159318	19	None	-1819	5	Human	5.7	pIC50	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		46879894	6181	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity to human EP2 receptor by radioligand displacement assayBinding affinity to human EP2 receptor by radioligand displacement assay	ChEMBL	565	6	1	5	7.2	Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12	10.1016/j.bmcl.2009.09.084
		CHEMBL1081186	6181	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Binding affinity to human EP2 receptor by radioligand displacement assayBinding affinity to human EP2 receptor by radioligand displacement assay	ChEMBL	565	6	1	5	7.2	Cc1cn(Cc2ccc(Cl)cc2Cl)c2c(-c3cc(NS(=O)(=O)c4ccc(F)c(F)c4)no3)cc(F)cc12	10.1016/j.bmcl.2009.09.084
		122180297	121647	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586362	121647	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	437	3	1	4	4.9	C[C@@H]1COc2c(Cl)cc(-n3ccc4cc(F)ccc43)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
		1883	3082	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
		1916	3082	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
		5280360	3082	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
		913	3082	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
		CHEMBL548	3082	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
		DB00917	3082	75	None	-6	24	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to human EP2 receptor (unknown origin) by radioligand displacement assayBinding affinity to human EP2 receptor (unknown origin) by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2013.03.016
		1883	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
		1916	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
		5280360	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
		913	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
		CHEMBL548	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
		DB00917	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cells measured after 120 mins by scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.11.014
		1883	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
		1916	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
		5280360	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
		913	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
		CHEMBL548	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
		DB00917	3082	75	None	-6	24	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human recombinant prostanoid EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2016.03.006
		122180249	121601	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586312	121601	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cncnc1)C2	10.1021/acs.jmedchem.5b00567
		122180295	121644	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586359	121644	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	422	3	1	4	5.3	O=c1cc(CN2CCOc3c(Cl)cc(-c4csc5ccccc45)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
		30956824	121600	4	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586311	121600	4	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccncc1)C2	10.1021/acs.jmedchem.5b00567
		122180250	121602	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586313	121602	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	432	5	0	6	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1OC)C2	10.1021/acs.jmedchem.5b00567
		122180252	121604	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586315	121604	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	418	4	1	5	4.7	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(=O)[nH]c1)C2	10.1021/acs.jmedchem.5b00567
		122180288	121638	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586352	121638	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	3	0	4	5.7	Cc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		9885481	195383	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
		CHEMBL551951	195383	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	365	16	2	4	3.0	CCCCCC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
		11955276	150751	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
		CHEMBL3956391	150751	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	358	7	3	4	2.9	O=C(O)CCC/C=C\C[C@H]1C(=O)C[C@@H](O)[C@@H]1c1ccc2c(c1)CCC2O	nan
		44570666	183270	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	522	6	1	4	4.5	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
		CHEMBL479664	183270	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human EP2 receptor by radioligand binding assayBinding affinity to human EP2 receptor by radioligand binding assay	ChEMBL	522	6	1	4	4.5	CC12CCCC(/C=C/C(=O)NS(=O)(=O)c3ccc(F)c(F)c3)=C1N(Cc1ccc(F)c(F)c1)C(=O)C2	10.1016/j.bmcl.2008.12.027
		58905388	158666	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	383	6	2	3	4.4	O=C(O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
		CHEMBL4092846	158666	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	383	6	2	3	4.4	O=C(O)c1ccc(CNC(=O)c2cc(F)ccc2Oc2ccc(F)cc2)cc1	10.1016/j.bmcl.2017.01.067
		10670992	60056	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	444	13	4	5	4.4	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1	10.1021/jm990542v
		CHEMBL173680	60056	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	444	13	4	5	4.4	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(O)CSc1cccc(Cl)c1	10.1021/jm990542v
		15486806	100487	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	392	13	4	4	3.5	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	10.1021/jm990542v
		CHEMBL290969	100487	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	392	13	4	4	3.5	O=C(O)CCCCCC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1	10.1021/jm990542v
		45270403	195117	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	14	2	4	2.5	CC(C)CC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
		CHEMBL550015	195117	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	14	2	4	2.5	CC(C)CC(O)CCCN(CCCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
		10180	3592	58	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
		49843471	3592	58	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
		CHEMBL2386081	3592	58	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
		DB12562	3592	58	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	402	3	1	3	4.2	Fc1ccc2c(c1)c1CN(CCc1n2CC(=O)O)C(=O)c1cccc2c1cccc2	10.1021/jm400122f
		45271237	195099	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL549870	195099	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.0	CCCCc1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		122180275	121624	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586338	121624	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	1	4	4.6	COc1cc(-c2c[nH]c3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		71733910	90335	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	436	3	1	3	4.9	O=C(O)Cn1c2c(c3cc(F)cc(Cl)c31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
		CHEMBL2385900	90335	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	436	3	1	3	4.9	O=C(O)Cn1c2c(c3cc(F)cc(Cl)c31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
		18376258	195902	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL559065	195902	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	465	9	1	3	5.4	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
		122180263	121614	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586326	121614	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2cc3ccccc3s2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		22246983	195862	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL558671	195862	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	11	1	3	4.2	CS(=O)(=O)N(CCCCCCC(=O)O)Cc1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.01.059
		1883	3082	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		1916	3082	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		5280360	3082	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		913	3082	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		CHEMBL548	3082	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		DB00917	3082	75	None	-6	24	Human	8.5	pIC50	=	8.5	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		122180284	121633	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586347	121633	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	421	4	0	5	4.8	COc1cc(N2CCc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180265	121616	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586328	121616	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	396	4	0	4	5.3	COc1cc(-c2cccc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180274	121623	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586337	121623	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	4	0	5	4.4	COc1cc(-n2ccc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180254	121606	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(Cl)cc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586317	121606	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(Cl)cc1)C2	10.1021/acs.jmedchem.5b00567
		122180255	121607	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	415	4	0	4	6.3	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C)cc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586318	121607	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	415	4	0	4	6.3	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C)cc1)C2	10.1021/acs.jmedchem.5b00567
		122180260	121612	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(Cl)c1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586323	121612	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	435	4	0	4	6.6	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccc(Cl)c1)C2	10.1021/acs.jmedchem.5b00567
		45269575	196405	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	12	1	4	4.0	CCCCc1ccc(CN(CCCOc2cccc(C(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL562825	196405	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	12	1	4	4.0	CCCCc1ccc(CN(CCCOc2cccc(C(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		45271234	195083	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	11	1	4	3.5	CCCCc1ccc(CN(Cc2ccccc2OCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL549663	195083	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	11	1	4	3.5	CCCCc1ccc(CN(Cc2ccccc2OCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		45268716	195998	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	10	1	3	4.0	CCCCc1ccc(CN(c2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL559955	195998	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	389	10	1	3	4.0	CCCCc1ccc(CN(c2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		16664733	154827	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of human recombinant EP2 receptor expressed in 293EBNA cellsInhibition of human recombinant EP2 receptor expressed in 293EBNA cells	ChEMBL	483	9	3	5	4.3	CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1	10.1016/j.bmcl.2006.12.025
		CHEMBL400404	154827	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of human recombinant EP2 receptor expressed in 293EBNA cellsInhibition of human recombinant EP2 receptor expressed in 293EBNA cells	ChEMBL	483	9	3	5	4.3	CC(=O)Nc1cccc(-c2ccc(Cc3ocnc3C(=O)N[C@@H](Cc3ccccc3)C(=O)O)cc2)c1	10.1016/j.bmcl.2006.12.025
		45266955	195645	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
		CHEMBL556416	195645	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	485	10	1	6	3.7	Cn1ccnc1CS(=O)(=O)N(Cc1ccc(C(C)(C)C)cc1)Cc1cccc(OCC(=O)O)c1	10.1016/j.bmcl.2009.01.059
		44627515	196837	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	572	6	1	5	7.2	Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12	10.1021/jm9005912
		CHEMBL565799	196837	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	572	6	1	5	7.2	Cc1cn(Cc2ccc3ccccc3c2)c2c(/C=C/C(=O)NS(=O)(=O)c3cc(Cl)c(Cl)s3)cc(F)cc12	10.1021/jm9005912
		11618662	158822	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	421	6	2	5	4.6	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		CHEMBL4094572	158822	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	421	6	2	5	4.6	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(C#N)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		11955257	153886	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL3983069	153886	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	410	9	3	3	5.3	CC(C)(C)C(O)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
		1883	3082	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
		1916	3082	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
		5280360	3082	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
		913	3082	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
		CHEMBL548	3082	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
		DB00917	3082	75	None	-6	24	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm9018756
		1894	957	41	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
		5311053	957	41	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
		CHEMBL37853	957	41	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
		DB11507	957	41	None	-	5	Human	5.4	pIC50	=	5.4	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	424	11	4	5	3.2	OC(=O)CCC/C=C\C[C@H]1[C@@H](O)C[C@H]([C@@H]1/C=C/[C@H](COc1cccc(c1)Cl)O)O	10.1021/jm990542v
		118175009	136685	0	None	-812	2	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
		CHEMBL3740325	136685	0	None	-812	2	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
		45271238	195641	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL556333	195641	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	8	1	3	4.0	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		1883	3082	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
		1916	3082	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
		5280360	3082	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
		913	3082	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
		CHEMBL548	3082	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
		DB00917	3082	75	None	-6	24	Human	8.4	pIC50	=	8.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.8b00808
		122180272	121621	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586335	121621	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	6	4.8	COc1cc(-c2nsc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180278	121627	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586341	121627	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3c(Cl)cccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180292	121642	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	3	0	4	5.4	CN1CCN(Cc2cccnc2)Cc2cc(-c3csc4ccccc34)ccc21	10.1021/acs.jmedchem.5b00567
		CHEMBL3586356	121642	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	385	3	0	4	5.4	CN1CCN(Cc2cccnc2)Cc2cc(-c3csc4ccccc34)ccc21	10.1021/acs.jmedchem.5b00567
		11296282	1409	32	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
		5822	1409	32	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
		CHEMBL565591	1409	32	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	590	6	1	5	7.3	Clc1ccc(c(c1)Cl)Cn1cc(c2c1c(/C=C/C(=O)NS(=O)(=O)c1sc(c(c1)Cl)Cl)cc(c2)F)C	10.1021/jm9005912
		44230999	167446	26	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
		CHEMBL4297666	167446	26	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	520	11	1	9	3.4	CC(C)OC(=O)CNc1cccc(CN(Cc2ccc(-n3cccn3)cc2)S(=O)(=O)c2cccnc2)n1	10.1021/acs.jmedchem.8b00808
		11955235	152751	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	9	3	3	4.2	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		CHEMBL3973312	152751	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	9	3	3	4.2	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		44564571	186815	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
		CHEMBL489310	186815	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
		11683088	158978	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		CHEMBL4096216	158978	0	None	-	1	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1ccc(F)cc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		162671048	182807	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting methodDisplacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting method	ChEMBL	451	5	1	4	5.4	Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1	10.1021/acs.jmedchem.0c00834
		CHEMBL4790821	182807	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting methodDisplacement of [3H]prostaglandin E2 from full-length recombinant human EP2 receptor expressed in HEK293 cell membranes measured after 120 mins by scintillation counting method	ChEMBL	451	5	1	4	5.4	Cc1c(-c2cccs2)nc2ccc(Br)cc2c1C(=O)NCCc1cccnc1	10.1021/acs.jmedchem.0c00834
		9934368	138921	11	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptorBinding affinity to rat EP2 receptor	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1021/jm9018756
		CHEMBL378376	138921	11	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptorBinding affinity to rat EP2 receptor	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1021/jm9018756
		9934368	138921	11	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1016/j.bmcl.2006.01.018
		CHEMBL378376	138921	11	None	-	1	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	469	10	2	4	4.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CC[C@@H](O)Cc2cccc(C(F)(F)F)c2)s1	10.1016/j.bmcl.2006.01.018
		44627395	196872	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	563	7	1	7	5.6	O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
		CHEMBL565992	196872	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor after 1 hr by liquid scintillation counting	ChEMBL	563	7	1	7	5.6	O=C(COc1cccc2ncn(Cc3ccc(Cl)cc3Cl)c12)NS(=O)(=O)c1cc(Cl)c(Cl)s1	10.1021/jm9005912
		11955410	152529	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	9	2	4	4.3	COC(=O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(C)(C)CO)cc2)[C@H](O)C[C@H]1Cl	nan
		CHEMBL3971493	152529	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	9	2	4	4.3	COC(=O)CCC/C=C\C[C@@H]1[C@@H](c2ccc(C(C)(C)CO)cc2)[C@H](O)C[C@H]1Cl	nan
		5311239	130618	31	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	358	14	4	4	3.5	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O	10.1021/jm990542v
		CHEMBL36817	130618	31	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	358	14	4	4	3.5	CCCCC[C@H](O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1CCCCCCC(=O)O	10.1021/jm990542v
		45268715	195976	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL559760	195976	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccccc2CCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		25114442	3061	56	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210307
		5817	3061	56	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210307
		CHEMBL3286797	3061	56	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210307
		DB12024	3061	56	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2Affinity Biochemical interaction (Enzymatic inhibition assay) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210307
		1883	3082	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
		1916	3082	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
		5280360	3082	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
		913	3082	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
		CHEMBL548	3082	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
		DB00917	3082	75	None	-7	24	Rat	8.3	pIC50	=	8.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2009.01.059
		1929	1605	55	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
		9890801	1605	55	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
		CHEMBL563646	1605	55	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
		DB12022	1605	55	None	-	2	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1016/j.bmcl.2009.01.059
		22246895	195564	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL554823	195564	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	399	14	2	4	3.7	CCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		18376196	194922	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL541516	194922	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	466	9	1	4	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2ccccn2)cc1	10.1016/j.bmcl.2009.01.059
		58681352	154339	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
		CHEMBL3986829	154339	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	486	10	3	4	5.5	CCCC1(C(O)c2cccc([C@H]3[C@H](O)C[C@@H](Cl)[C@@H]3Cc3cccc(OCC(=O)O)c3)c2)CCC1	nan
		122180281	121630	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cccc(Cl)c32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586344	121630	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cccc(Cl)c32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		16048029	195504	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	10	1	3	3.8	CC(C)(C)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL553468	195504	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	369	10	1	3	3.8	CC(C)(C)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		122180277	121626	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586340	121626	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2cc(Cl)c3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180257	121609	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	459	5	0	6	5.8	COC(=O)c1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586320	121609	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	459	5	0	6	5.8	COC(=O)c1ccc(CN2CCOc3c(cc(-c4csc5ccccc45)cc3OC)C2)cc1	10.1021/acs.jmedchem.5b00567
		122180258	121610	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C#N)cc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586321	121610	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	426	4	0	5	5.8	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccc(C#N)cc1)C2	10.1021/acs.jmedchem.5b00567
		122180291	121641	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	371	3	1	4	5.4	c1cncc(CN2CCNc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586355	121641	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	371	3	1	4	5.4	c1cncc(CN2CCNc3ccc(-c4csc5ccccc45)cc3C2)c1	10.1021/acs.jmedchem.5b00567
		11955358	153082	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
		CHEMBL3976116	153082	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	364	8	2	2	4.7	O=C(O)CCCCCC[C@@H]1[C@@H](c2ccc3c(c2)CCC3)[C@H](O)C[C@H]1Cl	nan
		18376082	194923	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL541517	194923	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	472	9	1	5	4.8	CC(C)(C)c1ccc(CN(Cc2cccc(CCC(=O)O)c2)S(=O)(=O)c2nccs2)cc1	10.1016/j.bmcl.2009.01.059
		22246956	196319	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL562291	196319	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	411	15	1	4	4.2	CCCCCC(=O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		44409917	139250	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(F)c2)s1	10.1016/j.bmcl.2006.01.018
		CHEMBL378968	139250	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	419	10	2	4	3.9	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2cccc(F)c2)s1	10.1016/j.bmcl.2006.01.018
		122180273	121622	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586336	121622	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	386	4	0	6	3.8	COc1cc(-n2cnc3ccccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		11539410	90339	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	438	5	1	3	5.2	CCc1ccc(-c2ccc(C(=O)N3CCc4c(c5ccccc5n4CC(=O)O)C3)cc2)cc1	10.1021/jm400122f
		CHEMBL2385904	90339	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	438	5	1	3	5.2	CCc1ccc(-c2ccc(C(=O)N3CCc4c(c5ccccc5n4CC(=O)O)C3)cc2)cc1	10.1021/jm400122f
		45269576	195983	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL559820	195983	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	4.4	CCCCc1ccc(CN(c2ccc(CCCC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		11653874	90359	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	384	3	1	3	4.1	O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
		CHEMBL2386079	90359	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	384	3	1	3	4.1	O=C(O)Cn1c2c(c3ccccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
		1955	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
		5311240	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
		CHEMBL36041	16	1	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Affinity for Prostanoid EP2 receptor expressed in CHO cellsAffinity for Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	428	13	4	5	3.6	O[C@@H](COc1cccc(c1)Cl)CC[C@H]1[C@H](O)C[C@@H]([C@@H]1CCCCCCC(=O)O)O	10.1021/jm990542v
		44409733	140884	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	401	10	2	4	3.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2)s1	10.1016/j.bmcl.2006.01.018
		CHEMBL382029	140884	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	401	10	2	4	3.8	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccccc2)s1	10.1016/j.bmcl.2006.01.018
		30897313	121598	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586309	121598	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		42484632	121599	5	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586310	121599	5	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	402	4	0	5	5.4	COc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1ccccn1)C2	10.1021/acs.jmedchem.5b00567
		122180270	121619	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586333	121619	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	380	4	0	4	4.8	COc1cc(-c2cccc(Cl)c2)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		22246893	195952	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL559561	195952	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	371	13	1	4	2.7	CCCCc1ccc(CN(CCCCOCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		11524454	946	55	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
		5857	946	55	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
		CHEMBL591666	946	55	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	413	6	2	3	5.5	Clc1ccc(c(c1)C(=O)N[C@H](c1ccc(cc1)C(=O)O)C)Oc1ccc(cc1)F	10.1016/j.bmcl.2017.01.067
		68505327	90360	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	418	3	1	3	4.7	O=C(O)Cn1c2c(c3cc(Cl)ccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
		CHEMBL2386080	90360	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	418	3	1	3	4.7	O=C(O)Cn1c2c(c3cc(Cl)ccc31)CN(C(=O)c1cccc3ccccc13)CC2	10.1021/jm400122f
		44564892	180522	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
		CHEMBL475348	180522	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc21	10.1016/j.bmcl.2008.12.112
		10126807	195098	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL549869	195098	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	405	8	1	4	3.4	CC(C)(C)c1ccc(CN(Cc2cccc(OCC(=O)O)c2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		56927669	121645	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586360	121645	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	423	3	1	4	4.5	O=c1cc(CN2CCOc3c(Cl)cc(-n4ccc5cc(F)ccc54)cc3C2)cc[nH]1	10.1021/acs.jmedchem.5b00567
		122180296	121646	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
		CHEMBL3586361	121646	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	436	3	1	4	5.7	C[C@@H]1COc2c(Cl)cc(-c3csc4ccccc34)cc2CN1Cc1cc[nH]c(=O)c1	10.1021/acs.jmedchem.5b00567
		122180279	121628	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586342	121628	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3cc(Cl)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180289	121639	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586353	121639	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	406	3	0	4	6.0	Clc1cc(-c2csc3ccccc23)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		122180280	121629	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586343	121629	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	419	4	0	5	5.1	COc1cc(-n2ccc3ccc(Cl)cc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		22246765	195198	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL550619	195198	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	403	11	1	3	3.7	CCCCc1ccc(CN(CCc2ccc(CC(=O)O)cc2)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		44409918	165973	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccc(Cl)cc2)s1	10.1016/j.bmcl.2006.01.018
		CHEMBL425243	165973	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity to rat EP2 receptor expressed in HEK293 cellsBinding affinity to rat EP2 receptor expressed in HEK293 cells	ChEMBL	435	10	2	4	4.4	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2CCC(O)Cc2ccc(Cl)cc2)s1	10.1016/j.bmcl.2006.01.018
		11955236	146456	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL3922121	146456	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	396	10	3	3	4.5	CC(C)(CO)c1ccc([C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
		122180283	121632	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		CHEMBL3586346	121632	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assayDisplacement of [3H]-PGE2 from human EP2 receptor overexpressed in human ECV304 cell membranes by scintillation proximity assay	ChEMBL	403	4	0	5	4.6	COc1cc(-n2ccc3cc(F)ccc32)cc2c1OCCN(Cc1cccnc1)C2	10.1021/acs.jmedchem.5b00567
		45268713	195951	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	15	2	4	2.6	CCCCCC(O)CCCN(CCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
		CHEMBL559560	195951	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	351	15	2	4	2.6	CCCCCC(O)CCCN(CCCCCC(=O)O)S(C)(=O)=O	10.1016/j.bmcl.2009.01.059
		10223499	196341	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		CHEMBL562411	196341	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inhibition of rat EP2 receptor expressed in HEK293 cellsInhibition of rat EP2 receptor expressed in HEK293 cells	ChEMBL	413	15	2	4	4.1	CCCCCC(O)c1ccc(CN(CCCCCCC(=O)O)S(C)(=O)=O)cc1	10.1016/j.bmcl.2009.01.059
		44564893	180523	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
		CHEMBL475349	180523	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	554	6	1	5	6.2	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
		71733912	90338	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	430	5	1	3	4.5	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)CCc1cccc3ccccc13)CC2	10.1021/jm400122f
		CHEMBL2385903	90338	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assayInhibition of beta-arrestin binding to recombinant human prostanoid EP2 receptor expressed in HEK293 cell membranes by beta-lactamase complementation assay	ChEMBL	430	5	1	3	4.5	O=C(O)Cn1c2c(c3cc(F)ccc31)CN(C(=O)CCc1cccc3ccccc13)CC2	10.1021/jm400122f
		44564804	176700	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
		CHEMBL459885	176700	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of radioligand from EP2 receptorDisplacement of radioligand from EP2 receptor	ChEMBL	536	6	1	5	6.1	Cn1cc(/C=C/C(=O)NS(=O)(=O)c2ccc(F)c(F)c2)c2c(Oc3ccc(Cl)cc3Cl)cccc21	10.1016/j.bmcl.2008.12.112
		25114442	3061	56	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210121
		5817	3061	56	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210121
		CHEMBL3286797	3061	56	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210121
		DB12024	3061	56	None	-	1	Human	8.7	pKd	=	8.7	Binding	Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2Affinity On-target Cellular interaction (Functional reporter assay (prostaglandin E2 (PGE2)-induced increase in cAMP in CHO cells expressing EP2 receptors)) EUB0000351a PTGER2	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.6019/CHEMBL5210121
		CHEMBL5281349	194110	0	None	-	1	Human	7.9	pKd	=	7.9	Binding	Binding affinity to human recombinant PTGER2 assessed as dissociation constant by high throughput fluorescence polarization assayBinding affinity to human recombinant PTGER2 assessed as dissociation constant by high throughput fluorescence polarization assay	ChEMBL	1581	31	10	14	8.1	CC(C)C[C@H]1CN(CC(=O)NCCC(=O)N[C@@H](CCCCNC(=S)Nc2ccccc2)C(N)=O)C(=O)CCSCc2ccc(cc2)C(=O)N[C@@H](CC(C)C)CN(C(=O)CC2CC2)CC(=O)N[C@@H](CCCCN)CN(C(=O)CCc2ccccc2)CC(=O)N[C@@H](Cc2ccccc2)CN(C(=O)CCC2CCCCC2)CC(=O)N1	10.1016/j.bmcl.2023.129255
		CHEMBL5279002	194009	0	None	-	1	Human	7.8	pKd	=	7.8	Binding	Binding affinity to human recombinant PTGER2 assessed as dissociation constant by high throughput fluorescence polarization assayBinding affinity to human recombinant PTGER2 assessed as dissociation constant by high throughput fluorescence polarization assay	ChEMBL	1921	33	12	18	12.0	CC(C)C[C@H]1CN(CC(=O)NCCC(=O)N[C@@H](CCCCNC(=S)Nc2ccc(-c3c4ccc(=O)cc-4oc4cc(O)ccc34)c(C(=O)O)c2)C(N)=O)C(=O)CCSCc2ccc(cc2)C(=O)N[C@@H](CCCCN)CN(C(=O)CCc2ccccc2)CC(=O)N[C@@H](CC(C)C)CN(C(=O)CCC2CCCCC2)CC(=O)N[C@@H](Cc2ccccc2)CN(C(=O)Cc2ccc3ccccc3c2)CC(=O)N1	10.1016/j.bmcl.2023.129255
		46213069	3063	0	None	1905	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to EP2 receptor in human mast cell assessed as inhibition constantBinding affinity to EP2 receptor in human mast cell assessed as inhibition constant	ChEMBL	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	10.1021/acs.jmedchem.1c00816
		8538	3063	0	None	1905	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to EP2 receptor in human mast cell assessed as inhibition constantBinding affinity to EP2 receptor in human mast cell assessed as inhibition constant	ChEMBL	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	10.1021/acs.jmedchem.1c00816
		CHEMBL5285583	3063	0	None	1905	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to EP2 receptor in human mast cell assessed as inhibition constantBinding affinity to EP2 receptor in human mast cell assessed as inhibition constant	ChEMBL	456	7	1	5	4.2	COc1ccc(cc1)C(=O)N1CCC(C1)(COc1ccc(cc1)c1ccc(cc1)C#N)C(=O)O	10.1021/acs.jmedchem.1c00816
		9807448	203172	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorCompound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL64246	203172	0	None	1	4	Human	9.1	pKi	=	9.1	Binding	Compound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorCompound was evaluated for its competitive binding affinity towards human Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		1883	3082	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
		1916	3082	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
		5280360	3082	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
		913	3082	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
		CHEMBL548	3082	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
		DB00917	3082	75	None	-6	24	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/acs.jmedchem.9b00336
		51039069	129203	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(F)cc2)cc1	nan
		CHEMBL3670659	129203	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(F)cc2)cc1	nan
		51039071	129207	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccccc3)cc2-c2ccc(F)cc2)o1	nan
		CHEMBL3670663	129207	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	419	6	4	4	4.1	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccccc3)cc2-c2ccc(F)cc2)o1	nan
		10481859	75167	0	None	-4	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
		CHEMBL2036321	75167	0	None	-4	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1C	10.1016/j.bmc.2012.04.008
		1932	2942	5	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
		5311228	2942	5	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
		CHEMBL3286796	2942	5	None	1	6	Human	8.8	pKi	=	8.8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10.1021/jm401431x
		1883	3082	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		1916	3082	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		5280360	3082	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		913	3082	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		CHEMBL548	3082	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		DB00917	3082	75	None	-6	24	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.ejmech.2013.01.044
		57384034	71307	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
		CHEMBL1957436	71307	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.02.018
		57384034	71307	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
		CHEMBL1957436	71307	0	None	-2	3	Mouse	8.8	pKi	=	8.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	528	10	2	6	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc(Cl)cc3)c2)n1	10.1016/j.bmc.2012.04.008
		67078793	129197	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	287	3	2	2	4.2	O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1	nan
		CHEMBL3670653	129197	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	287	3	2	2	4.2	O=C(O)c1[nH]c(-c2cccs2)cc1-c1ccc(F)cc1	nan
		18376177	3753	50	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
		5816	3753	50	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
		CHEMBL2107783	3753	50	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
		DB12623	3753	50	None	-	1	Human	8.0	pKi	=	8	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	478	10	1	7	3.1	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1021/jm401431x
		11855865	153277	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3977724	153277	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		10116114	125886	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL364841	125886	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		13231966	100951	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
		CHEMBL294108	100951	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
		13231966	100951	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL294108	100951	0	None	-141	5	Mouse	7.0	pKi	=	7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	372	13	3	5	3.2	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
		44455046	95727	0	None	-50118	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
		CHEMBL258332	95727	0	None	-50118	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	413	8	2	3	3.7	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.11.020
		44304057	203259	0	None	-288	4	Mouse	6.0	pKi	=	6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.6	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL64598	203259	0	None	-288	4	Mouse	6.0	pKi	=	6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.6	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
		10181606	206351	0	None	-645	7	Human	5.0	pKi	=	5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
		CHEMBL87371	206351	0	None	-645	7	Human	5.0	pKi	=	5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
		118517483	144271	0	None	-93	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
		CHEMBL3904946	144271	0	None	-93	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
		71455094	81881	0	None	-407	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	623	12	1	8	6.4	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
		CHEMBL2164609	81881	0	None	-407	4	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	623	12	1	8	6.4	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
		44303627	203205	0	None	467	2	Mouse	8.0	pKi	=	8.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL64358	203205	0	None	467	2	Mouse	8.0	pKi	=	8.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	364	11	3	3	4.5	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		5311035	97803	29	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.09.074
		CHEMBL271896	97803	29	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.09.074
		52941778	16542	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	712	14	2	4	11.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1Oc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1Oc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237304	16542	0	None	-1	3	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	712	14	2	4	11.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1Oc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1Oc1ccccc1	10.1016/j.bmcl.2004.11.051
		5311035	97803	29	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.11.020
		CHEMBL271896	97803	29	None	-4	9	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/j.bmcl.2007.11.020
		44390782	64603	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	10	1	3	5.5	COc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL181691	64603	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	10	1	3	5.5	COc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		44303907	202741	0	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	390	10	3	4	3.5	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CC#CCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL61925	202741	0	None	-	1	Mouse	6.0	pKi	=	6.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	390	10	3	4	3.5	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CC#CCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		10431288	69366	0	None	-1318	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	403	12	2	3	4.5	CCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		CHEMBL1929546	69366	0	None	-1318	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	403	12	2	3	4.5	CCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		46201043	200582	0	None	-5011	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
		CHEMBL599154	200582	0	None	-5011	3	Mouse	6.0	pKi	=	6.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
		9939791	161918	0	None	-912	8	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
		CHEMBL415310	161918	0	None	-912	8	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
		9873528	206930	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	7	1	5	6.9	O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1	10.1016/s0960-894x(99)00465-5
		CHEMBL91063	206930	0	None	-72	4	Human	5.0	pKi	=	5.0	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	7	1	5	6.9	O=C(NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)OCc1ccccc1	10.1016/s0960-894x(99)00465-5
		134155748	151169	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		CHEMBL3959653	151169	0	None	25	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	2	4	4.7	CCCCCC(=O)c1ccc([C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		11502897	142793	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3892847	142793	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11502897	142793	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3892847	142793	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	431	11	2	5	4.8	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		119461	320	72	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
		1896	320	72	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
		CHEMBL1317823	320	72	None	-3	10	Human	5.9	pKi	=	5.9	Binding	Inhibition of EP2 receptor (unknown origin) by competitive binding assayInhibition of EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10.1021/jm401431x
		118517359	144396	0	None	-114	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
		CHEMBL3906016	144396	0	None	-114	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
		24952927	201231	0	None	-851	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1	10.1021/jm901771h
		CHEMBL603690	201231	0	None	-851	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(C(F)(F)F)cc1	10.1021/jm901771h
		44304404	100581	0	None	-23	4	Mouse	7.9	pKi	=	7.9	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	12	3	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
		CHEMBL291630	100581	0	None	-23	4	Mouse	7.9	pKi	=	7.9	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	12	3	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
		10291963	84708	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		CHEMBL222715	84708	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		44520989	199764	0	None	-2	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	396	6	2	4	5.0	Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOc1ccccc1/C=C/C(=O)O)O2	10.1016/j.bmc.2009.08.007
		CHEMBL593764	199764	0	None	-2	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	396	6	2	4	5.0	Cc1c(C)c2c(c(C)c1O)CCC(C)(CCOc1ccccc1/C=C/C(=O)O)O2	10.1016/j.bmc.2009.08.007
		23016719	201220	0	None	-1	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		CHEMBL603625	201220	0	None	-1	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(OCc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		44304055	102723	0	None	-371	4	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL304887	102723	0	None	-371	4	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCSCCC(=O)O	10.1016/s0960-894x(01)00364-x
		44304034	200594	0	None	-165	3	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
		CHEMBL59921	200594	0	None	-165	3	Mouse	5.9	pKi	=	5.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
		9817405	165403	5	None	-165	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2006.08.025
		CHEMBL423815	165403	5	None	-165	6	Human	4.9	pKi	=	4.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	288	4	1	1	4.5	O=C(O)/C=C/c1ccccc1Cc1ccc2ccccc2c1	10.1016/j.bmcl.2006.08.025
		72695027	106266	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
		CHEMBL3115074	106266	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
		CHEMBL3138992	106266	0	None	-28	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor by liquid scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2015.05.091
		72706947	174664	20	None	-5128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	363	11	2	3	3.4	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
		CHEMBL4558749	174664	20	None	-5128	3	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	363	11	2	3	3.4	CCC#CC[C@H](C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
		118517488	153711	0	None	-56	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
		CHEMBL3981554	153711	0	None	-56	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
		44442327	94459	0	None	-147	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		CHEMBL251294	94459	0	None	-147	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		17757350	152754	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
		CHEMBL3973347	152754	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	413	12	3	4	5.1	CCCCCC(O)c1ccc([C@@H]2[C@@H](C/C=C\CCCC(=O)O)[C@H](C#N)C[C@H]2O)cc1	nan
		10112412	69468	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933719	69468	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
		10112412	69468	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1933719	69468	0	None	-208	3	Mouse	6.9	pKi	=	6.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	9	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
		118517489	143691	0	None	-44	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
		CHEMBL3900245	143691	0	None	-44	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
		51039070	129204	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	433	6	5	5	4.2	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(O)cc2)cc1	nan
		CHEMBL3670660	129204	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	433	6	5	5	4.2	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(O)cc2)cc1	nan
		44303626	168182	0	None	-	1	Mouse	7.9	pKi	=	7.9	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL433249	168182	0	None	-	1	Mouse	7.9	pKi	=	7.9	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		57400249	69477	0	None	3	3	Mouse	7.9	pKi	=	7.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	410	9	2	6	3.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CC2CCCC2)n1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933728	69477	0	None	3	3	Mouse	7.9	pKi	=	7.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	410	9	2	6	3.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CC2CCCC2)n1	10.1016/j.bmcl.2011.10.109
		10291963	84708	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
		CHEMBL222715	84708	0	None	-74	6	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
		11315933	123294	4	None	-707	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	413	7	1	4	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL361457	123294	4	None	-707	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	413	7	1	4	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
		44394432	127326	0	None	-10	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL365908	127326	0	None	-10	5	Mouse	5.9	pKi	=	5.9	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		23017109	200074	0	None	-6	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	416	10	1	5	4.3	O=C(O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		CHEMBL595830	200074	0	None	-6	2	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	416	10	1	5	4.3	O=C(O)COCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		15907747	207023	0	None	-257	4	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
		CHEMBL91537	207023	0	None	-257	4	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	684	8	1	5	7.2	CO[C@@](C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)(c1ccccc1)C(F)(F)F	10.1016/s0960-894x(99)00465-5
		118517361	153370	0	None	-218	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
		CHEMBL3978590	153370	0	None	-218	2	Human	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
		9975502	94489	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		CHEMBL251504	94489	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		3356	2280	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
		4326	2280	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
		9867642	2280	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
		CHEMBL426559	2280	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
		DB11629	2280	73	None	-53	8	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	10.1021/jm0603668
		70667255	151474	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3962183	151474	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2C=CCc2ccc(C(=O)O)s2)cc1	nan
		24760052	151185	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3959769	151185	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	10	2	4	5.4	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2/C=C/Cc2ccc(C(=O)O)s2)cc1	nan
		44304436	203320	0	None	-35	5	Mouse	7.9	pKi	=	7.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	400	14	3	5	3.8	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL64854	203320	0	None	-35	5	Mouse	7.9	pKi	=	7.9	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	400	14	3	5	3.8	CCCC[C@H](C)C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCCCC(=O)O	10.1016/s0960-894x(01)00364-x
		44320373	206250	0	None	5	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	376	9	1	2	5.8	O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1	10.1016/s0960-894x(02)00518-8
		CHEMBL86799	206250	0	None	5	4	Human	6.9	pKi	=	6.9	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	376	9	1	2	5.8	O=C(O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1	10.1016/s0960-894x(02)00518-8
		52947851	16545	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237315	16545	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2004.11.051
		52947851	16545	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
		CHEMBL1237315	16545	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	528	10	2	2	8.1	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
		9813912	137882	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	264	5	1	1	4.0	O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
		CHEMBL376282	137882	0	None	-14	3	Human	5.9	pKi	=	5.9	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	264	5	1	1	4.0	O=C(O)/C=C/c1ccccc1C/C=C/c1ccccc1	10.1016/j.bmcl.2006.08.025
		57394140	69371	0	None	-707	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	419	13	2	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		CHEMBL1929550	69371	0	None	-707	3	Mouse	5.9	pKi	=	5.9	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	419	13	2	4	4.1	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		134146425	149203	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL3943966	149203	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	12	2	2	6.4	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
		11519006	102486	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
		CHEMBL2373410	102486	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
		CHEMBL3040272	102486	0	None	-229	6	Human	5.9	pKi	=	5.9	Binding	Inhibition of [3H]PGE-2 binding to Prostanoid EP2 receptorInhibition of [3H]PGE-2 binding to Prostanoid EP2 receptor	ChEMBL	481	8	1	5	6.1	O=C(O)COc1cccc(C[C@@H]2CCC[C@H]3O[C@]23c2nc(-c3ccccc3)c(-c3ccccc3)o2)c1	10.1016/j.bmcl.2005.04.076
		9808508	111560	0	None	-245	3	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	586	7	1	4	6.3	O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
		CHEMBL328067	111560	0	None	-245	3	Human	4.9	pKi	=	4.9	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	586	7	1	4	6.3	O=C(Cc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
		44455115	95562	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		CHEMBL257658	95562	0	None	-15	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	387	10	2	3	4.1	CCCCC(C)(C)[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		118517359	144396	0	None	-114	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
		CHEMBL3906016	144396	0	None	-114	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
		44289922	163524	0	None	-954	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
		CHEMBL42027	163524	0	None	-954	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
		11855868	152544	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3971632	152544	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		57393340	69475	0	None	-10	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	530	12	2	7	4.2	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933726	69475	0	None	-10	4	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	530	12	2	7	4.2	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(COCC(F)(F)F)c2)n1	10.1016/j.bmcl.2011.10.109
		11855868	152544	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3971632	152544	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	2	4	5.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		57894053	75170	0	None	-79	3	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
		CHEMBL2036324	75170	0	None	-79	3	Mouse	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	551	10	2	8	5.4	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
		155516303	170077	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2cccc3oc(C(=O)O)cc23)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
		CHEMBL4443289	170077	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2cccc3oc(C(=O)O)cc23)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
		18973764	16647	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	346	8	1	2	5.1	O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1	10.1016/s0960-894x(03)00794-7
		CHEMBL124199	16647	0	None	1	4	Human	6.8	pKi	=	6.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	346	8	1	2	5.1	O=C(O)c1ccc(CCCc2ccccc2OCc2ccccc2)cc1	10.1016/s0960-894x(03)00794-7
		44304058	203177	0	None	-66	5	Mouse	6.8	pKi	=	6.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	374	13	3	6	2.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL64254	203177	0	None	-66	5	Mouse	6.8	pKi	=	6.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	374	13	3	6	2.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCOCC(=O)O	10.1016/s0960-894x(01)00364-x
		23017216	199159	0	None	-1380	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	439	9	2	3	5.4	O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12	10.1016/j.bmc.2009.11.023
		CHEMBL589411	199159	0	None	-1380	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	439	9	2	3	5.4	O=C(O)CCc1ccc(COc2ccccc2)cc1C(=O)NCc1cccc2ccccc12	10.1016/j.bmc.2009.11.023
		44304051	102760	0	None	-213	4	Mouse	5.8	pKi	=	5.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
		CHEMBL305126	102760	0	None	-213	4	Mouse	5.8	pKi	=	5.8	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)cc1	10.1016/s0960-894x(01)00364-x
		134143292	145228	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		CHEMBL3912658	145228	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	12	1	3	6.5	CCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		59465595	145423	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
		CHEMBL3914108	145423	0	None	-	1	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)c1	nan
		59465574	145945	0	None	1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
		CHEMBL3918084	145945	0	None	1	2	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	400	12	1	4	5.7	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)OC)cc1	nan
		118517490	153155	0	None	-125	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
		CHEMBL3976710	153155	0	None	-125	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
		72695027	106266	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
		CHEMBL3115074	106266	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
		CHEMBL3138992	106266	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysisDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cell membranes after 90 mins by topcount scintillation counting analysis	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	10.1021/ml5000367
		72695027	106266	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
		CHEMBL3115074	106266	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
		CHEMBL3138992	106266	0	None	-28	2	Human	5.8	pKi	=	5.8	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3H]-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	396	8	2	4	3.5	C[C@H](NC(=O)[C@H]1CCCCN1CCOc1ccccc1)c1ccc(C(=O)O)cc1	nan
		24952577	200561	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	399	6	2	3	5.2	C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
		CHEMBL599051	200561	0	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	399	6	2	3	5.2	C[C@H](NC(=O)c1cscc1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
		1929	1605	55	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
		9890801	1605	55	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
		CHEMBL563646	1605	55	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
		DB12022	1605	55	None	-11	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/acs.jmedchem.8b00808
		44349503	168390	0	None	-100	4	Human	5.8	pKi	=	5.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	553	10	1	5	7.1	O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
		CHEMBL434637	168390	0	None	-100	4	Human	5.8	pKi	=	5.8	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	553	10	1	5	7.1	O=C(CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(03)00794-7
		44419351	84143	0	None	-28	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	533	12	1	5	6.2	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
		CHEMBL220821	84143	0	None	-28	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	533	12	1	5	6.2	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
		44324368	96518	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	587	6	2	4	6.8	O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
		CHEMBL262690	96518	0	None	-3	4	Human	4.8	pKi	=	4.8	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	587	6	2	4	6.8	O=C(Nc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
		10144273	205834	0	None	-131	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	558	8	1	5	7.2	O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL83450	205834	0	None	-131	4	Human	4.8	pKi	=	4.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	558	8	1	5	7.2	O=C(CCc1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		11855871	146408	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3921784	146408	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855871	146408	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3921784	146408	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	429	11	1	5	4.9	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855866	144602	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3907809	144602	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855866	144602	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3907809	144602	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	403	9	2	5	4.0	CCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		53494965	64813	0	None	-5	3	Mouse	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C	10.1016/j.bmc.2011.08.007
		CHEMBL1819611	64813	0	None	-5	3	Mouse	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1ccc(CC(=O)O)cc1NC(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1C	10.1016/j.bmc.2011.08.007
		52947847	16538	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1.Cc1cccc(C/C=C\c2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237300	16538	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1.Cc1cccc(C/C=C\c2ccc(/C=C/C(=O)O)cc2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		11314979	66109	0	None	-11	4	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	379	7	1	4	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL183933	66109	0	None	-11	4	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	379	7	1	4	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(C)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		11234840	125055	0	None	-4	2	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1cccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)c1	10.1016/j.bmcl.2004.06.006
		CHEMBL364421	125055	0	None	-4	2	Mouse	5.8	pKi	=	5.8	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1cccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)c1	10.1016/j.bmcl.2004.06.006
		56949973	69372	0	None	-3388	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	407	11	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		CHEMBL1929551	69372	0	None	-3388	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	407	11	2	4	3.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		57894092	75158	0	None	-8511	3	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	12	2	6	4.5	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
		CHEMBL2036312	75158	0	None	-8511	3	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	12	2	6	4.5	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
		10157810	63787	0	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	400	9	1	3	5.6	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1021/ml300191g
		CHEMBL180191	63787	0	None	3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	400	9	1	3	5.6	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1021/ml300191g
		44442334	94528	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	327	7	1	2	3.8	CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		CHEMBL251710	94528	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	327	7	1	2	3.8	CC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		11495634	14905	13	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
		CHEMBL1207972	14905	13	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
		CHEMBL467114	14905	13	None	-218	4	Mouse	5.8	pKi	=	5.8	Binding	Antagonist activity at mouse EP2 receptorAntagonist activity at mouse EP2 receptor	ChEMBL	405	6	1	3	5.4	O=C(O)c1cccc(Cc2cc(Cl)ccc2OCc2ccc(Cl)cc2F)n1	10.1016/j.bmcl.2012.11.046
		92135977	152896	0	None	-275	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
		CHEMBL3974652	152896	0	None	-275	2	Human	5.8	pKi	=	5.8	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
		52945421	16536	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237298	16536	0	None	2	4	Human	7.8	pKi	=	7.8	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(OCc2ccccc2)c1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(OCc2ccccc2)c1	10.1016/j.bmcl.2004.11.051
		21362912	171175	0	None	-8	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	5	6.7	O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL445895	171175	0	None	-8	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	5	6.7	O=C(CCCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		23017362	199978	0	None	-45	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	10	1	4	5.1	O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		CHEMBL595157	199978	0	None	-45	4	Mouse	5.8	pKi	=	5.8	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	10	1	4	5.1	O=C(O)CCCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		11577792	159318	19	None	-1819	5	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		CHEMBL4099851	159318	19	None	-1819	5	Human	5.7	pKi	=	5.7	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	414	6	2	4	4.9	C[C@H](NC(=O)c1cc(Cl)cnc1Oc1cccc(F)c1)c1ccc(C(=O)O)cc1	10.1016/j.bmcl.2017.01.067
		10448293	154421	0	None	-41	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	313	6	1	2	3.4	CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		CHEMBL398947	154421	0	None	-41	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	313	6	1	2	3.4	CC(C)=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		11855324	142605	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3891401	142605	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		57395059	69474	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933725	69474	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmcl.2011.10.109
		57395059	69474	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmc.2012.02.018
		CHEMBL1933725	69474	0	None	-12	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	418	9	2	6	3.1	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)n1	10.1016/j.bmc.2012.02.018
		11855865	153277	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3977724	153277	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	445	12	2	5	5.2	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		57403612	71305	0	None	-239	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	433	9	2	4	4.2	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmc.2012.02.018
		CHEMBL1957434	71305	0	None	-239	3	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	433	9	2	4	4.2	O=C(O)c1ccc(CCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)s1	10.1016/j.bmc.2012.02.018
		15948325	2526	45	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
		5856	2526	45	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
		CHEMBL402162	2526	45	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	603	11	1	8	4.7	CCOc1c2CN(C(=O)c2c(c2c1nccc2)OCC)c1ccc(cc1C)CS(=O)(=O)NC(=O)Cc1ccccc1OC	10.1016/j.bmcl.2008.01.103
		59465577	143189	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL3896183	143189	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	408	13	2	2	6.8	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)cc1	nan
		57893982	75164	0	None	-4	3	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
		CHEMBL2036318	75164	0	None	-4	3	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	508	10	2	6	5.1	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
		57464006	75168	0	None	-17	4	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
		CHEMBL2036322	75168	0	None	-17	4	Mouse	8.7	pKi	=	8.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	534	10	2	7	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3cc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
		9807448	203172	0	None	-1	4	Mouse	8.7	pKi	=	8.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL64246	203172	0	None	-1	4	Mouse	8.7	pKi	=	8.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		67078538	129198	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	269	3	3	3	3.3	O=C(O)c1[nH]c(-c2ccoc2)cc1-c1ccc(O)cc1	nan
		CHEMBL3670654	129198	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	269	3	3	3	3.3	O=C(O)c1[nH]c(-c2ccoc2)cc1-c1ccc(O)cc1	nan
		44303952	100886	0	None	41	4	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL293697	100886	0	None	41	4	Mouse	7.7	pKi	=	7.7	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	14	3	4	4.8	CCCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		10361472	65208	0	None	-199	3	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)cc3c(CC(=O)O)cccc32)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL182555	65208	0	None	-199	3	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)cc3c(CC(=O)O)cccc32)cc1	10.1016/j.bmcl.2004.07.039
		10118889	206273	0	None	-74	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL86933	206273	0	None	-74	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1cccc(CSCCc2ccccc2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		11187675	65214	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL182572	65214	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
		12002527	75160	0	None	-19952	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	493	12	2	5	5.1	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2cc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
		CHEMBL2036314	75160	0	None	-19952	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	493	12	2	5	5.1	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2cc3ccccc3o2)c1	10.1016/j.bmc.2012.04.008
		24953628	200603	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1	10.1021/jm901771h
		CHEMBL599262	200603	0	None	-63	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1ccc(Cl)cc1	10.1021/jm901771h
		57529188	147195	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3928130	147195	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		57529188	147195	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3928130	147195	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	415	11	2	5	4.3	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		44444721	154406	0	None	-77	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL398827	154406	0	None	-77	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
		44455084	97867	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
		CHEMBL272277	97867	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	399	10	2	3	4.2	CCCCC1([C@@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.11.020
		58932681	75172	0	None	-100	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
		CHEMBL2036326	75172	0	None	-100	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
		10116116	64411	0	None	-26	5	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		CHEMBL1813115	64411	0	None	-26	5	Mouse	6.7	pKi	=	6.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		10206535	66572	0	None	-398	4	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	488	6	1	6	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccc(F)cc3O2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL185251	66572	0	None	-398	4	Mouse	5.7	pKi	=	5.7	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	488	6	1	6	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccc(F)cc3O2)cc1	10.1016/j.bmcl.2004.07.039
		44320126	206412	0	None	-17	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	537	11	1	7	6.2	Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		CHEMBL87816	206412	0	None	-17	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	537	11	1	7	6.2	Cc1cccc(OCCCOc2ccc(-c3ccccc3COC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		22009011	64073	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
		CHEMBL180742	64073	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(/C=C/C(O)c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
		11187675	65214	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL182572	65214	0	None	-61	4	Mouse	5.7	pKi	=	5.7	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	365	7	1	4	4.4	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)cc1	10.1016/j.bmcl.2004.06.006
		44419380	83079	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
		CHEMBL218178	83079	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
		44419384	83080	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
		CHEMBL218179	83080	0	None	-208	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	529	10	1	5	6.4	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)c1	10.1016/j.bmcl.2006.08.025
		57894081	75154	0	None	-3467	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	503	12	2	4	5.6	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2012.04.008
		CHEMBL2036308	75154	0	None	-3467	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	503	12	2	4	5.6	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2012.04.008
		23017746	199849	0	None	-13	3	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	8	1	3	6.2	O=C(O)/C=C/c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		CHEMBL594365	199849	0	None	-13	3	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	414	8	1	3	6.2	O=C(O)/C=C/c1ccc(Cc2cccs2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		9846782	100905	7	None	-676	3	Mouse	5.7	pKi	=	5.7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	454	13	3	7	2.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		CHEMBL293856	100905	7	None	-676	3	Mouse	5.7	pKi	=	5.7	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	454	13	3	7	2.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		15907748	111464	0	None	-147	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	615	7	2	4	7.0	C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
		CHEMBL327597	111464	0	None	-147	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	615	7	2	4	7.0	C[C@H](NC(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
		138	3081	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		1882	3081	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		5280723	3081	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		CHEMBL495	3081	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		DB00770	3081	88	None	-19	18	Mouse	7.7	pKi	=	7.7	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		1883	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
		1916	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
		5280360	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
		913	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
		CHEMBL548	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
		DB00917	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2011.10.109
		1883	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
		1916	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
		5280360	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
		913	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
		CHEMBL548	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
		DB00917	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmc.2012.02.018
		57396660	71308	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.02.018
		CHEMBL1957437	71308	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.02.018
		57396660	71308	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.04.008
		CHEMBL1957437	71308	0	None	-1819	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	544	10	2	6	5.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccc4ccccc4c3)c2)n1	10.1016/j.bmc.2012.04.008
		10348321	75171	0	None	-87	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	585	10	2	8	6.0	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
		CHEMBL2036325	75171	0	None	-87	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	585	10	2	8	6.0	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4s3)c2)n1	10.1016/j.bmc.2012.04.008
		58932678	75288	0	None	-104	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
		CHEMBL2037290	75288	0	None	-104	3	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1cccc2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc12	10.1016/j.bmc.2012.04.008
		56672020	64825	0	None	-1	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	7	2	5	4.6	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3F)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		CHEMBL1819623	64825	0	None	-1	2	Mouse	7.7	pKi	=	7.7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	7	2	5	4.6	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3F)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		11337782	84943	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	373	10	2	3	3.6	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
		CHEMBL223744	84943	0	None	-12	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	373	10	2	3	3.6	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2CC[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
		9863804	94098	0	None	-8	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249136	94098	0	None	-8	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	11	2	4	2.7	CCCCCC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
		9938669	168058	0	None	-154	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	8	1	5	6.2	O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
		CHEMBL432380	168058	0	None	-154	4	Human	4.7	pKi	=	4.7	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	602	8	1	5	6.2	O=C(COc1ccccc1)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
		10113454	177501	0	None	-1380	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	429	12	2	3	4.4	O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
		CHEMBL46395	177501	0	None	-1380	3	Human	4.7	pKi	=	4.7	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	429	12	2	3	4.4	O=C(O)CCCCCCN1C(=O)CC[C@@H]1CC[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
		118517483	144271	0	None	-93	2	Human	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
		CHEMBL3904946	144271	0	None	-93	2	Human	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccccc2F)cc1	nan
		11488860	19291	0	None	-5370	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to prostanoid receptor EP2 receptorBinding affinity to prostanoid receptor EP2 receptor	ChEMBL	497	5	1	4	5.7	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	10.1016/j.bmcl.2010.10.018
		CHEMBL1290413	19291	0	None	-5370	8	Human	5.6	pKi	=	5.6	Binding	Binding affinity to prostanoid receptor EP2 receptorBinding affinity to prostanoid receptor EP2 receptor	ChEMBL	497	5	1	4	5.7	C[C@@H](c1ccc(C(F)(F)F)cc1)n1c2c(c3cc(F)cc(S(C)(=O)=O)c31)CCC[C@@H]2CC(=O)O	10.1016/j.bmcl.2010.10.018
		24760055	143888	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
		CHEMBL3901873	143888	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
		24760055	143888	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
		CHEMBL3901873	143888	0	None	-2	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	411	10	2	4	4.6	CCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COc2ccc(C(=O)O)cc2)cc1	nan
		11855591	144436	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
		CHEMBL3906402	144436	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
		11855591	144436	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
		CHEMBL3906402	144436	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	435	9	2	5	4.0	O=C(O)c1ccc(COC[C@H]2CCC(=O)N2c2ccc(C(O)Cc3ccccc3)cc2)o1	nan
		10414412	75166	0	None	-6	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1	10.1016/j.bmc.2012.04.008
		CHEMBL2036320	75166	0	None	-6	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	522	10	2	6	5.4	Cc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)c(C)c1	10.1016/j.bmc.2012.04.008
		11408533	141327	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
		CHEMBL383484	141327	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
		11408533	141327	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
		CHEMBL383484	141327	0	None	-89	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	459	6	1	5	4.5	CC(=O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
		11743212	17164	0	None	-758	7	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	426	7	1	3	6.8	O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL125588	17164	0	None	-758	7	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	426	7	1	3	6.8	O=C(O)C1CC1c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		56658143	64805	0	None	-16	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	468	8	2	6	3.4	CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		CHEMBL1819604	64805	0	None	-16	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	468	8	2	6	3.4	CN1C[C@@H](COc2ccc(S(=O)(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		9809136	106889	0	None	-2290	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	614	7	1	4	7.1	CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
		CHEMBL314533	106889	0	None	-2290	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	614	7	1	4	7.1	CC(C)(C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1)c1ccccc1	10.1016/s0960-894x(99)00465-5
		9874010	207190	0	None	-1348	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	629	8	1	4	6.9	CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
		CHEMBL92539	207190	0	None	-1348	8	Human	4.6	pKi	=	4.6	Binding	Affinity at human EP2 receptor.Affinity at human EP2 receptor.	ChEMBL	629	8	1	4	6.9	CN(CCc1ccccc1)C(=O)NS(=O)(=O)c1ccccc1-c1ccc(CN2C(=O)c3ccccc3CCc3ccccc32)cc1	10.1016/s0960-894x(99)00465-5
		10229201	155576	0	None	-87	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL404414	155576	0	None	-87	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	508	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(I)c2)cc1	10.1016/j.bmcl.2007.09.074
		10076580	75289	0	None	-158	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	563	10	2	8	5.5	Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
		CHEMBL2037291	75289	0	None	-158	3	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	563	10	2	8	5.5	Cc1cc(C)c2oc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)nc2c1	10.1016/j.bmc.2012.04.008
		132836	59695	23	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	10.1021/jm401431x
		CHEMBL1722929	59695	23	None	1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	10.1021/jm401431x
		57403799	69469	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933720	69469	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmcl.2011.10.109
		57403799	69469	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1933720	69469	0	None	-6	2	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	9	2	5	2.8	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)co2)c1	10.1016/j.bmc.2012.02.018
		5311035	97803	29	None	-4	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
		CHEMBL271896	97803	29	None	-4	9	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1021/jm401431x
		44303980	168074	0	None	-	1	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL432522	168074	0	None	-	1	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	408	13	2	5	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	10.1016/s0960-894x(01)00359-6
		22009004	141751	0	None	-2884	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1021/ml300191g
		CHEMBL385955	141751	0	None	-2884	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1021/ml300191g
		10270893	94228	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249954	94228	0	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	376	12	2	4	3.1	CCCCCC(O)CCCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
		44303889	203217	0	None	-	1	Mouse	7.6	pKi	=	7.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL64423	203217	0	None	-	1	Mouse	7.6	pKi	=	7.6	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	414	10	3	4	4.2	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/s0960-894x(01)00359-6
		17751059	148268	0	None	56	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		CHEMBL3936540	148268	0	None	56	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		21974328	66270	0	None	-26	5	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	443	6	1	6	4.4	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL184684	66270	0	None	-26	5	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	443	6	1	6	4.4	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Oc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		10228100	64414	0	None	-43	5	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	488	6	1	6	4.7	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		CHEMBL1813118	64414	0	None	-43	5	Mouse	6.6	pKi	=	6.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	488	6	1	6	4.7	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		44349551	16814	0	None	-47	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	415	8	2	4	6.2	O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL124675	16814	0	None	-47	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	415	8	2	4	6.2	O=C(O)CNc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		10158725	16828	0	None	-109	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL124738	16828	0	None	-109	4	Human	5.6	pKi	=	5.6	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		44320405	106165	0	None	-5	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.2	O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL313700	106165	0	None	-5	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.2	O=C(NS(=O)(=O)CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)c1cccs1	10.1016/s0960-894x(02)00518-8
		52944194	16543	0	None	-194	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	936	18	4	6	12.8	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
		CHEMBL1237305	16543	0	None	-194	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	936	18	4	6	12.8	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(CO)c1OCc1c(Cl)cccc1Cl.O=C(O)/C=C/c1ccccc1C/C=C/c1cccc(CO)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
		52947852	16546	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237316	16546	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2004.11.051
		52947852	16546	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
		CHEMBL1237316	16546	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	588	12	2	4	8.1	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1.COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
		44419388	83415	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	294	6	1	2	4.0	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
		CHEMBL219590	83415	0	None	-37	3	Human	5.6	pKi	=	5.6	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	294	6	1	2	4.0	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)O)cc1	10.1016/j.bmcl.2006.08.025
		11339240	84728	0	None	-3548	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	423	10	2	4	3.2	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
		CHEMBL222834	84728	0	None	-3548	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	423	10	2	4	3.2	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
		9885106	84773	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmcl.2011.10.109
		CHEMBL223151	84773	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmcl.2011.10.109
		9885106	84773	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmc.2012.02.018
		CHEMBL223151	84773	0	None	-1258	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1016/j.bmc.2012.02.018
		44304258	102356	0	None	-114	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL303787	102356	0	None	-114	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
		44455158	97721	0	None	-933	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	331	8	2	3	2.6	CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		CHEMBL271488	97721	0	None	-933	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	331	8	2	3	2.6	CCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		9821171	97866	0	None	-51286	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
		CHEMBL272276	97866	0	None	-51286	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	379	8	2	3	3.1	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.11.020
		44304011	202808	0	None	-83	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL62305	202808	0	None	-83	3	Mouse	5.6	pKi	=	5.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	440	12	3	7	2.4	COc1ccccc1C[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
		44290263	101329	0	None	-3235	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	453	12	3	4	5.2	Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1	10.1016/j.bmcl.2004.01.063
		CHEMBL296715	101329	0	None	-3235	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	453	12	3	4	5.2	Cc1cc(O)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCCCCCC(=O)O)c1	10.1016/j.bmcl.2004.01.063
		77050677	128584	0	None	-588	2	Human	6.6	pKi	=	6.6	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	385	10	2	4	3.7	CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1	nan
		CHEMBL3667607	128584	0	None	-588	2	Human	6.6	pKi	=	6.6	Binding	In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.In Vitro Binding Assay: hEP1 and hEP4 membranes are prepared from recombinant HEK293 cells stably expressing the human EP1 (Genbank accession number AY275470) or EP4 (Genbank accession number AY429109) receptors. hEP2 and hEP3 membranes are prepared from HEK293 cells transiently transfected with EP2 (Genbank accession number AY275471) or EP3 (isoform VI: Genbank accession number AY429108) receptor plasmids. Frozen cell pellets are homogenized in homogenization buffer using a Teflon/glass homogenizer. Membrane protein is aliquoted and quick frozen on dry ice prior to storage at -80 C. Homogenization buffer contained 10 mM Tris-HCl, pH 7.4, 250 mM sucrose, 1 mM EDTA, 0.3 mM indomethacin and plus Complete, with EDTA, obtained from Roche Molecular Biochemicals (Catalog Number 1 697 498).Kd values for [3]H-PGE2 binding to each receptor are determined by saturation binding studies or homologous competition. Compounds are tested in a 96-well format using a three-fold dilution series.	ChEMBL	385	10	2	4	3.7	CC(C)[C@@H](OCCOc1ccccc1)C(=O)N[C@@H](C)c1ccc(C(=O)O)cc1	nan
		11855325	144691	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3908484	144691	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells at pH 6 after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		21362900	205840	0	None	-58	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL83518	205840	0	None	-58	4	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		11418818	66662	0	None	-14	4	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	423	10	1	5	5.2	CCCCOc1ccc(C(=O)n2c(C)c(CCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL185369	66662	0	None	-14	4	Mouse	5.6	pKi	=	5.6	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	423	10	1	5	5.2	CCCCOc1ccc(C(=O)n2c(C)c(CCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		53358921	64441	0	None	-562	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	482	7	1	5	5.4	CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1	10.1016/j.bmc.2011.06.014
		CHEMBL1813287	64441	0	None	-562	6	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	482	7	1	5	5.4	CCN1c2ccccc2C[C@@H]1COc1ccc(C(=O)n2c(C)c(CC(=O)O)c3ccccc32)c(C)c1	10.1016/j.bmc.2011.06.014
		10181606	206351	0	None	-645	7	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL87371	206351	0	None	-645	7	Human	4.6	pKi	=	4.6	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	437	5	1	4	5.2	O=C(/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		118517360	143975	0	None	-1380	2	Human	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
		CHEMBL3902700	143975	0	None	-1380	2	Human	5.6	pKi	=	5.6	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	412	8	2	3	4.7	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Cl)c2)cc1	nan
		44444714	94138	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249341	94138	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	362	10	2	4	2.6	CCCC(C)C(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
		57893848	75169	0	None	-234	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
		CHEMBL2036323	75169	0	None	-234	2	Mouse	7.6	pKi	=	7.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	535	10	2	8	4.9	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4ccccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
		21974362	122044	0	None	-1	4	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2COc3ccccc3C2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL359564	122044	0	None	-1	4	Mouse	6.6	pKi	=	6.6	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	4.9	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2COc3ccccc3C2)cc1	10.1016/j.bmcl.2004.07.039
		9886718	203163	0	None	-398	4	Mouse	6.6	pKi	=	6.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL64217	203163	0	None	-398	4	Mouse	6.6	pKi	=	6.6	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	390	13	3	6	2.7	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O	10.1016/s0960-894x(01)00364-x
		118175009	136685	0	None	-812	2	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
		CHEMBL3740325	136685	0	None	-812	2	Human	5.6	pKi	=	5.6	Binding	Antagonist activity at human EP2 receptorAntagonist activity at human EP2 receptor	ChEMBL	429	4	2	2	6.7	Cc1ccc(C(=O)O)c(C)c1NC(=O)c1cc(-c2cccc(Cl)c2)cc2ccccc12	10.1016/j.bmcl.2015.11.023
		10157813	201616	0	None	-177	4	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	400	9	1	4	4.7	O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		CHEMBL605833	201616	0	None	-177	4	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	400	9	1	4	4.7	O=C(O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		59465587	145190	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
		CHEMBL3912391	145190	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	372	13	2	2	6.5	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)O)cc1	nan
		10205205	94168	0	None	-47	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	466	10	2	5	3.3	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249539	94168	0	None	-47	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	466	10	2	5	3.3	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(OC(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
		10089562	154422	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		CHEMBL398948	154422	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		44304335	202978	0	None	-37	4	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	10	4	4	4.0	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
		CHEMBL63061	202978	0	None	-37	4	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	10	4	4	4.0	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C/CCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
		21362879	16568	0	None	-107	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1	10.1016/s0960-894x(03)00794-7
		CHEMBL123855	16568	0	None	-107	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1cc(-c2ccccc2OCc2ccccc2)cs1	10.1016/s0960-894x(03)00794-7
		21362853	18532	0	None	-32	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL127482	18532	0	None	-32	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2COc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		12112239	106560	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	549	12	1	6	6.3	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		CHEMBL314200	106560	0	None	-8	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	549	12	1	6	6.3	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		21362893	206327	0	None	-54	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	6	6.0	Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		CHEMBL87263	206327	0	None	-54	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	535	12	1	6	6.0	Cc1cccc(OCCCOc2ccc(-c3ccccc3CCC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		44320321	206434	0	None	-6	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	563	12	1	6	6.6	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		CHEMBL87975	206434	0	None	-6	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	563	12	1	6	6.6	Cc1cccc(OCCCOc2ccc(-c3ccccc3CC(C)(C)C(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		52941777	16540	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	744	16	2	4	10.9	Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237302	16540	0	None	1	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	744	16	2	4	10.9	Cc1cccc(/C=C/Cc2ccccc2CC(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2CC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		44393681	66861	0	None	-1	3	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	5.2	CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL186244	66861	0	None	-1	3	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	5.2	CCCCOc1ccc(C(=O)n2c(CCC)c(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		10202765	172687	0	None	-18197	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	427	11	2	3	4.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
		CHEMBL45008	172687	0	None	-18197	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	427	11	2	3	4.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
		71458758	120862	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
		CHEMBL2164612	120862	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
		CHEMBL3558858	120862	0	None	-21	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	615	14	1	4	7.8	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCC[n+]1c(C)cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc1C	10.1021/ml300191g
		57396825	69473	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933724	69473	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmcl.2011.10.109
		57396825	69473	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2012.02.018
		CHEMBL1933724	69473	0	None	-6	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	398	11	2	6	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSc1nc(C(=O)O)cs1	10.1016/j.bmc.2012.02.018
		57394893	71306	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
		CHEMBL1957435	71306	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.02.018
		57394893	71306	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
		CHEMBL1957435	71306	0	None	-3	4	Mouse	8.5	pKi	=	8.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	494	10	2	6	4.8	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3ccccc3)c2)n1	10.1016/j.bmc.2012.04.008
		51039072	129206	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	4	5	4.3	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2ccc(C(=O)NO)o2)cc1	nan
		CHEMBL3670662	129206	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	4	5	4.3	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2ccc(C(=O)NO)o2)cc1	nan
		9807448	203172	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
		CHEMBL64246	203172	0	None	1	4	Human	8.5	pKi	=	8.5	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	398	11	3	3	4.7	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1021/jm401431x
		10315	2926	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to EP2 (unknown origin) assessed as inhibition constantBinding affinity to EP2 (unknown origin) assessed as inhibition constant	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1016/j.ejmech.2021.113842
		44230575	2926	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to EP2 (unknown origin) assessed as inhibition constantBinding affinity to EP2 (unknown origin) assessed as inhibition constant	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1016/j.ejmech.2021.113842
		CHEMBL3707245	2926	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding affinity to EP2 (unknown origin) assessed as inhibition constantBinding affinity to EP2 (unknown origin) assessed as inhibition constant	ChEMBL	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	10.1016/j.ejmech.2021.113842
		67078580	129200	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	435	6	2	5	4.7	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
		CHEMBL3670656	129200	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	435	6	2	5	4.7	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
		51039068	129202	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	436	6	4	5	4.0	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
		CHEMBL3670658	129202	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	436	6	4	5	4.0	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3cccs3)cc2-c2ccc(F)cc2)nc1	nan
		44304164	203234	0	None	-	1	Mouse	7.5	pKi	=	7.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL64483	203234	0	None	-	1	Mouse	7.5	pKi	=	7.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	378	11	3	4	3.6	CCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		15947857	155513	7	None	-269	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	767	12	1	9	6.3	COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1	10.1016/j.bmcl.2008.01.103
		CHEMBL404199	155513	7	None	-269	7	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	767	12	1	9	6.3	COc1cccc(OC)c1C1(C(=O)NS(=O)(=O)Cc2ccc(N3Cc4c(c(OCC(F)(F)F)c5cccnc5c4OCC(F)(F)F)C3=O)c(C)c2)CC1	10.1016/j.bmcl.2008.01.103
		44320294	106007	0	None	-4	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	557	12	1	6	5.7	O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL313266	106007	0	None	-4	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	557	12	1	6	5.7	O=S(=O)(CCc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		230826	93431	32	None	-19	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at prostanoid EP2 receptorBinding affinity at prostanoid EP2 receptor	ChEMBL	268	4	1	2	3.9	O=C(O)COc1ccc(Cl)cc1C1CCCCC1	10.1016/j.bmcl.2007.05.019
		CHEMBL245908	93431	32	None	-19	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity at prostanoid EP2 receptorBinding affinity at prostanoid EP2 receptor	ChEMBL	268	4	1	2	3.9	O=C(O)COc1ccc(Cl)cc1C1CCCCC1	10.1016/j.bmcl.2007.05.019
		44269516	43633	30	None	-87	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
		CHEMBL15096	43633	30	None	-87	3	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CCC1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
		10413147	9080	0	None	-13182	3	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	486	10	3	3	7.2	Cc1cc(C)cc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
		CHEMBL1099047	9080	0	None	-13182	3	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	486	10	3	3	7.2	Cc1cc(C)cc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
		44444720	94227	0	None	-239	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249953	94227	0	None	-239	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
		11855870	146280	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3920756	146280	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		11855870	146280	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3920756	146280	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	427	11	1	4	5.7	CCCCCC(=O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		11269563	141610	0	None	-281	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	399	5	1	3	5.2	CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
		CHEMBL385126	141610	0	None	-281	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	399	5	1	3	5.2	CC(=O)c1cc(F)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
		10185382	64415	0	None	-30	5	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	1	7	4.6	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		CHEMBL1813119	64415	0	None	-30	5	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	1	7	4.6	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		9867899	203124	0	None	-97	3	Mouse	5.5	pKi	=	5.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	440	13	3	5	3.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2CCSCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
		CHEMBL64072	203124	0	None	-97	3	Mouse	5.5	pKi	=	5.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	440	13	3	5	3.6	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2CCSCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
		44303590	202911	0	None	-363	3	Mouse	5.5	pKi	=	5.5	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	468	14	3	7	2.6	COCCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		CHEMBL62779	202911	0	None	-363	3	Mouse	5.5	pKi	=	5.5	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	468	14	3	7	2.6	COCCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		21362867	107102	0	None	-128	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	417	7	1	5	4.6	CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/s0960-894x(02)00518-8
		CHEMBL315974	107102	0	None	-128	4	Human	4.5	pKi	=	4.5	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	417	7	1	5	4.6	CSc1cccc(-c2ccccc2CCC(=O)NS(=O)(=O)c2cccs2)c1	10.1016/s0960-894x(02)00518-8
		44269544	35252	0	None	-7762	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	359	11	2	3	3.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	10.1016/j.bmcl.2004.01.063
		CHEMBL14359	35252	0	None	-7762	3	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	359	11	2	3	3.2	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)Cc1ccccc1	10.1016/j.bmcl.2004.01.063
		118517488	153711	0	None	-56	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
		CHEMBL3981554	153711	0	None	-56	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2F)cc1	nan
		118517361	153370	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
		CHEMBL3978590	153370	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	446	8	2	3	5.1	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(C(F)(F)F)c2)cc1	nan
		57393339	69472	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933723	69472	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmcl.2011.10.109
		57393339	69472	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1933723	69472	0	None	-57	2	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ncc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
		44290312	178920	0	None	-87	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	421	11	2	3	5.0	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.063
		CHEMBL47018	178920	0	None	-87	2	Human	4.5	pKi	=	4.5	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	421	11	2	3	5.0	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2004.01.063
		72950089	150591	0	None	-1621	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
		CHEMBL3955128	150591	0	None	-1621	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	375	13	2	3	3.8	CCCCC[C@H](O)/C=C/[C@H]1CC(F)(F)C(=O)N1CCCCCCC(=O)O	10.1021/acs.jmedchem.9b00336
		21974331	126546	0	None	-5	4	Mouse	6.5	pKi	=	6.5	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	399	6	1	4	4.8	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL365243	126546	0	None	-5	4	Mouse	6.5	pKi	=	6.5	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	399	6	1	4	4.8	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
		10363130	101035	1	None	3	2	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL294585	101035	1	None	3	2	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		10185612	64413	0	None	-11	4	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		CHEMBL1813117	64413	0	None	-11	4	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2cc(Cl)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		11338015	66118	0	None	-1	2	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	381	7	2	5	4.2	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(O)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL183983	66118	0	None	-1	2	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	381	7	2	5	4.2	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(O)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		44303967	202958	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	12	3	4	4.8	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL62987	202958	0	None	-	1	Mouse	5.5	pKi	=	5.5	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	420	12	3	4	4.8	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCCC1	10.1016/s0960-894x(01)00359-6
		10294290	200053	0	None	-275	4	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	398	8	1	4	4.8	O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		CHEMBL595632	200053	0	None	-275	4	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	398	8	1	4	4.8	O=C(O)/C=C/c1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		50898361	56873	0	None	-2630	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	549	7	2	5	5.4	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	10.1016/j.bmcl.2010.11.118
		CHEMBL1644003	56873	0	None	-2630	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	549	7	2	5	5.4	Cc1ccc(S(=O)(=O)NC(=O)NCCc2ccc(-c3c(C(=O)N(C)C)sc4c(C)cc(C)cc34)cc2)cc1	10.1016/j.bmcl.2010.11.118
		44304474	202931	0	None	-91	5	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O	10.1016/s0960-894x(01)00365-1
		CHEMBL62868	202931	0	None	-91	5	Mouse	6.5	pKi	=	6.5	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCSCCC(=O)O	10.1016/s0960-894x(01)00365-1
		10277744	64412	0	None	-12	7	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		CHEMBL1813116	64412	0	None	-12	7	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		10291963	84708	0	None	-199	6	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2011.10.109
		CHEMBL222715	84708	0	None	-199	6	Mouse	6.5	pKi	=	6.5	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	359	10	2	3	3.4	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2011.10.109
		11476788	161274	0	None	-23	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	463	5	1	5	4.4	CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O	10.1016/j.bmcl.2008.03.015
		CHEMBL412070	161274	0	None	-23	6	Human	5.5	pKi	=	5.5	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	463	5	1	5	4.4	CS(=O)(=O)c1cc(F)cc2c1c(C(=O)c1ccc(Cl)cc1)c1n2CCC[C@@H]1CC(=O)O	10.1016/j.bmcl.2008.03.015
		92135977	152896	0	None	-275	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
		CHEMBL3974652	152896	0	None	-275	2	Human	5.5	pKi	=	5.5	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(F)c2)cc1	nan
		11405770	137908	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	361	11	2	3	3.6	CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
		CHEMBL376347	137908	0	None	-2	3	Human	7.5	pKi	=	7.5	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	361	11	2	3	3.6	CCCCC[C@H](O)CC[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1021/jm049290a
		21362910	16925	0	None	-5	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	9	1	2	7.0	O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL125269	16925	0	None	-5	4	Human	5.5	pKi	=	5.5	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	9	1	2	7.0	O=C(O)CCCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		57893867	75157	0	None	-12302	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	492	12	3	4	4.9	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3[nH]ccc3c2)c1	10.1016/j.bmc.2012.04.008
		CHEMBL2036311	75157	0	None	-12302	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	492	12	3	4	4.9	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccc3[nH]ccc3c2)c1	10.1016/j.bmc.2012.04.008
		56658144	64806	0	None	1	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(NC(=O)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		CHEMBL1819605	64806	0	None	1	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(NC(=O)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		44349531	16565	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	394	7	1	2	6.2	O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL123844	16565	0	None	-3	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	394	7	1	2	6.2	O=C(O)Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		21362849	168328	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	8	1	2	6.9	CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
		CHEMBL434247	168328	0	None	-4	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	422	8	1	2	6.9	CC(Cc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
		44269464	34477	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
		CHEMBL14286	34477	0	None	-3	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
		118517489	143691	0	None	-44	2	Human	5.4	pKi	=	5.4	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
		CHEMBL3900245	143691	0	None	-44	2	Human	5.4	pKi	=	5.4	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cc(F)ccc2F)cc1	nan
		44304417	202110	0	None	-138	4	Mouse	6.4	pKi	=	6.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	438	13	3	4	4.3	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
		CHEMBL60894	202110	0	None	-138	4	Mouse	6.4	pKi	=	6.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	438	13	3	4	4.3	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
		44303723	202935	0	None	-	1	Mouse	6.4	pKi	=	6.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL62885	202935	0	None	-	1	Mouse	6.4	pKi	=	6.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.4	CCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCCC1	10.1016/s0960-894x(01)00359-6
		53358922	64430	0	None	-70	6	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	522	6	1	6	5.3	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
		CHEMBL1813276	64430	0	None	-70	6	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	522	6	1	6	5.3	Cc1c(CC(=O)O)c2cc(F)ccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
		21362851	116904	0	None	-67	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL338388	116904	0	None	-67	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	408	8	1	2	6.6	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		10109445	85143	0	None	-537	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	365	10	2	4	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1	10.1021/jm049290a
		CHEMBL224970	85143	0	None	-537	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	365	10	2	4	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)s1	10.1021/jm049290a
		1883	3082	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		1916	3082	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		5280360	3082	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		913	3082	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		CHEMBL548	3082	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		DB00917	3082	75	None	-6	24	Human	7.4	pKi	=	7.4	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1021/jm401431x
		5283086	203310	24	None	-269	5	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
		CHEMBL64804	203310	24	None	-269	5	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O	10.1016/s0960-894x(01)00359-6
		10271490	165893	0	None	-29	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	9	1	2	5.8	Cc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL424975	165893	0	None	-29	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	9	1	2	5.8	Cc1cccc(CCCc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		44320433	167943	0	None	-45	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL431612	167943	0	None	-45	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	521	11	1	5	6.3	O=C(CCc1ccccc1-c1ccccc1CSCCc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		24953283	199448	0	None	-426	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
		CHEMBL591431	199448	0	None	-426	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
		11855594	152980	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3975238	152980	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855594	152980	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3975238	152980	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	417	10	2	5	4.4	CCCCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11294166	77045	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
		CHEMBL207203	77045	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1016/j.bmcl.2006.02.062
		11294166	77045	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
		CHEMBL207203	77045	0	None	-213	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	461	6	2	5	4.3	CC(O)c1cc(S(C)(=O)=O)cc2c3c(n(Cc4ccc(Cl)cc4)c12)[C@@H](CC(=O)O)CC3	10.1021/jm0603668
		22009003	122616	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
		CHEMBL360290	122616	0	None	-436	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	468	8	2	3	6.7	Cc1cccc(C(O)/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
		44304008	203242	0	None	-549	4	Mouse	5.4	pKi	=	5.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	410	11	3	6	2.4	O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1	10.1016/s0960-894x(01)00364-x
		CHEMBL64542	203242	0	None	-549	4	Mouse	5.4	pKi	=	5.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	410	11	3	6	2.4	O=C(O)CSCCCS[C@H]1C(=O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)Cc1ccccc1	10.1016/s0960-894x(01)00364-x
		44138108	184285	0	None	-12302	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
		CHEMBL483991	184285	0	None	-12302	6	Human	5.4	pKi	=	5.4	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
		51039064	129201	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
		CHEMBL3670657	129201	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
		1883	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
		1916	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
		5280360	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
		913	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
		CHEMBL548	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
		DB00917	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.09.074
		1883	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
		1916	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
		5280360	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
		913	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
		CHEMBL548	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
		DB00917	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.11.020
		1883	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
		1916	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
		5280360	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
		913	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
		CHEMBL548	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
		DB00917	3082	75	None	-6	24	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10.1016/j.bmcl.2007.05.025
		44304124	102623	0	None	-	1	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL304225	102623	0	None	-	1	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	12	3	4	4.3	CC(C)CC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		11855324	142605	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3891401	142605	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		11855324	142605	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		CHEMBL3891401	142605	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	371	6	1	4	4.0	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)o2)cc1	nan
		44269486	166842	0	None	-144	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
		CHEMBL428524	166842	0	None	-144	3	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	341	14	2	3	3.7	CCCCCC(O)CC[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
		138	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		1882	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		5280723	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		CHEMBL495	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		DB00770	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		138	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
		1882	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
		5280723	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
		CHEMBL495	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
		DB00770	3081	88	None	-19	18	Mouse	7.4	pKi	=	7.4	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00364-x
		10183680	127166	0	None	-2	3	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL365696	127166	0	None	-2	3	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		11597294	166176	4	None	-489	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	4	1	2	5.7	O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21	10.1021/jm0603668
		CHEMBL426387	166176	4	None	-489	8	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	ChEMBL	435	4	1	2	5.7	O=C(O)C[C@H]1CCc2c1n(Cc1ccc(Cl)cc1)c1c(Br)cc(F)cc21	10.1021/jm0603668
		57391585	69467	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933718	69467	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmcl.2011.10.109
		57391585	69467	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1933718	69467	0	None	-457	2	Mouse	6.4	pKi	=	6.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	393	8	2	3	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1016/j.bmc.2012.02.018
		10112486	16901	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1	10.1016/s0960-894x(03)00794-7
		CHEMBL125110	16901	0	None	-7	4	Human	5.4	pKi	=	5.4	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	414	8	1	3	6.7	O=C(O)CCc1ccccc1-c1ccc(-c2ccccc2OCc2ccccc2)s1	10.1016/s0960-894x(03)00794-7
		44390831	63637	0	None	-575	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	8	1	2	6.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1	10.1016/j.bmcl.2004.11.051
		CHEMBL180089	63637	0	None	-575	4	Human	5.4	pKi	=	5.4	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	402	8	1	2	6.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccc(F)cc1	10.1016/j.bmcl.2004.11.051
		44289969	101378	0	None	-17	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	345	10	2	3	3.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccccc1	10.1016/j.bmcl.2004.01.063
		CHEMBL297139	101378	0	None	-17	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	345	10	2	3	3.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccccc1	10.1016/j.bmcl.2004.01.063
		57398586	69476	0	None	-53	3	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	422	9	2	7	3.0	Cc1ccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)o1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933727	69476	0	None	-53	3	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	422	9	2	7	3.0	Cc1ccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)o1	10.1016/j.bmcl.2011.10.109
		44290262	178519	0	None	-10	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1	10.1016/j.bmcl.2004.01.063
		CHEMBL46671	178519	0	None	-10	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccc(Cl)cc2)c1	10.1016/j.bmcl.2004.01.063
		44290272	101443	0	None	-6760	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1	10.1016/j.bmcl.2004.01.063
		CHEMBL297578	101443	0	None	-6760	2	Human	4.4	pKi	=	4.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2ccccc2Cl)c1	10.1016/j.bmcl.2004.01.063
		44442327	94459	0	None	-147	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		CHEMBL251294	94459	0	None	-147	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	345	9	2	3	3.0	CCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		71462285	81880	0	None	-239	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	478	10	1	5	6.0	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
		CHEMBL2164608	81880	0	None	-239	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta countingDisplacement of [3H]PGE2 from human EP2R expressed in chem1 cells after 2hrs by beta counting	ChEMBL	478	10	1	5	6.0	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCCn1cc2ccccc2c1C#N	10.1021/ml300191g
		44303711	102352	0	None	18	3	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL303763	102352	0	None	18	3	Mouse	7.4	pKi	=	7.4	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	406	13	3	4	4.4	CCCCC1([C@@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2C/C=C\CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		24953285	200869	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	453	6	2	3	5.9	O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1	10.1021/jm901771h
		CHEMBL601299	200869	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	453	6	2	3	5.9	O=C(O)c1ccc(CNC(=O)c2c(Cl)sc(Cl)c2Cc2cccc(Cl)c2)cc1	10.1021/jm901771h
		155520370	170476	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2ccc3cc(C(=O)O)oc3c2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
		CHEMBL4448995	170476	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation countingDisplacement of [3H]prostaglandin E2 from human EP2 receptor expressed in HEK293 cell membranes after 60 mins by liquid scintillation counting	ChEMBL	478	7	1	5	5.2	CC(C)(C)c1ccc(CN(Cc2ccc3cc(C(=O)O)oc3c2)S(=O)(=O)c2cccnc2)cc1	10.1021/acs.jmedchem.8b00808
		56665068	64824	0	None	-3	4	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	2	5	5.1	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		CHEMBL1819622	64824	0	None	-3	4	Mouse	7.4	pKi	=	7.4	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	500	7	2	5	5.1	CN1C[C@@H](COc2ccc(C(=O)Nc3cc(CC(=O)O)ccc3Cl)c(Cl)c2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		10269242	155575	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL404413	155575	0	None	-2	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	348	9	2	4	2.2	CC(C)CC(O)CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.09.074
		21974528	124450	0	None	-22	5	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	441	6	1	5	4.6	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL363984	124450	0	None	-22	5	Mouse	6.4	pKi	=	6.4	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	441	6	1	5	4.6	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2Cc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		44289922	163524	0	None	-954	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/j.bmcl.2004.01.063
		CHEMBL42027	163524	0	None	-954	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	339	13	2	3	3.5	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/j.bmcl.2004.01.063
		10227492	16898	0	None	-218	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	476	8	1	2	7.9	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL125087	16898	0	None	-218	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	476	8	1	2	7.9	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2OCc2c(Cl)cccc2Cl)c1	10.1016/s0960-894x(03)00794-7
		44349528	113801	0	None	-131	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	7.2	CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL332446	113801	0	None	-131	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	7.2	CC(CC(=O)O)c1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		59465601	149894	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		CHEMBL3949271	149894	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.4	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		24953286	201384	0	None	-151	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1	10.1021/jm901771h
		CHEMBL604546	201384	0	None	-151	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	427	6	2	3	5.8	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(Cl)c1	10.1021/jm901771h
		54013831	146460	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		CHEMBL3922151	146460	0	None	3	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		9845064	69348	0	None	-194	3	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	420	13	2	5	3.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)[C@@H]2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		CHEMBL1929528	69348	0	None	-194	3	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	420	13	2	5	3.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)[C@@H]2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		11395329	123847	0	None	-17	2	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL362541	123847	0	None	-17	2	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	395	8	1	5	4.5	CCCCOc1ccc(C(=O)n2c(C)c(CC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		9885106	84773	0	None	-2344	6	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1021/jm049290a
		CHEMBL223151	84773	0	None	-2344	6	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	357	13	2	4	3.1	CCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCSCCCC(=O)O	10.1021/jm049290a
		44304389	203153	0	None	-40	4	Mouse	7.3	pKi	=	7.3	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O	10.1016/s0960-894x(01)00365-1
		CHEMBL64188	203153	0	None	-40	4	Mouse	7.3	pKi	=	7.3	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCSCC(=O)O	10.1016/s0960-894x(01)00365-1
		10168694	206349	0	None	-309	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	671	17	1	7	8.2	O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL87366	206349	0	None	-309	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	671	17	1	7	8.2	O=C(CCc1ccccc1-c1ccc(OCCCOc2cccc(CSCCc3ccccc3)c2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		12521	2197	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
		72722131	2197	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
		CHEMBL3918816	2197	0	None	-20892	4	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting methodDisplacement of [3H]PGE2 from human recombinant EP2 receptor expressed in HEK293 cell membranes after 120 mins by liquid scintillation counting method	ChEMBL	399	11	2	3	3.6	FC1(C(N([C@H](C1)/C=C/[C@H]([C@H](CC#CCC)C)O)CCCCCCC(=O)O)=O)F	10.1021/acs.jmedchem.9b00336
		1929	1605	55	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
		9890801	1605	55	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
		CHEMBL563646	1605	55	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
		DB12022	1605	55	None	-11	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	468	9	1	5	4.2	OC(=O)COc1cccc(c1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)C(C)(C)C	10.1021/jm401431x
		10299717	64417	0	None	-144	6	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21	10.1016/j.bmc.2011.06.014
		CHEMBL1813120	64417	0	None	-144	6	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	484	6	1	6	4.9	Cc1cc(OC[C@@H]2CN(C)c3ccccc3O2)ccc1C(=O)n1c(C)c(CC(=O)O)c2ccccc21	10.1016/j.bmc.2011.06.014
		59465588	143526	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		CHEMBL3898887	143526	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	422	13	1	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		59465575	145067	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
		CHEMBL3911438	145067	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	402	13	1	4	5.9	CCCCCC(O)c1cccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)OC)c1	nan
		59465592	149702	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
		CHEMBL3947785	149702	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CCC=C2CCCCCCC(=O)OC)cc1	nan
		59465590	150945	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		CHEMBL3957958	150945	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	406	13	1	3	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)OC)cc1	nan
		59465584	151430	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
		CHEMBL3961847	151430	0	None	-	1	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	394	13	2	2	6.7	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCCO)cc1	nan
		11855325	144691	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3908484	144691	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855325	144691	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3908484	144691	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	387	6	1	4	4.5	CC(C)(C)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		57564500	151210	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		CHEMBL3959926	151210	0	None	4	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	440	12	2	2	6.8	CCCCCC(O)c1ccc([C@H]2[C@@H](Cl)C[C@@H](Cl)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		12137443	84703	0	None	-5495	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	491	9	2	3	6.1	Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
		CHEMBL222677	84703	0	None	-5495	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	491	9	2	3	6.1	Cc1cc(Cl)ccc1-c1cccc([C@H](O)CC[C@H]2CCC(=O)N2CCc2ccc(C(=O)O)cc2)c1	10.1021/jm049290a
		11224239	64804	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		CHEMBL1819603	64804	0	None	-1	4	Mouse	6.3	pKi	=	6.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	7	2	5	3.8	CN1C[C@@H](COc2ccc(C(=O)Nc3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		11282034	66630	0	None	-13	3	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	437	11	1	5	5.6	CCCCOc1ccc(C(=O)n2c(C)c(CCCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL185277	66630	0	None	-13	3	Mouse	5.3	pKi	=	5.3	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	437	11	1	5	5.6	CCCCOc1ccc(C(=O)n2c(C)c(CCCCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		46887240	8754	0	None	-13489	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	472	10	3	3	6.9	Cc1cccc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
		CHEMBL1096382	8754	0	None	-13489	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	472	10	3	3	6.9	Cc1cccc(Nc2ccc(CCC(=O)O)c(C(=O)N[C@H](CC(C)C)c3cc(C)cc(C)c3)c2)c1	10.1016/j.bmc.2010.03.028
		52945419	16534	0	None	-478	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	772	16	4	6	10.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237296	16534	0	None	-478	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	772	16	4	6	10.7	O=C(O)/C=C/c1ccccc1/C=C/Cc1cccc(O)c1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1cccc(O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		56672018	64807	0	None	-6	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	446	7	1	5	3.9	CN1C[C@@H](COc2ccc(C(=O)N(C)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		CHEMBL1819606	64807	0	None	-6	3	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	446	7	1	5	3.9	CN1C[C@@H](COc2ccc(C(=O)N(C)c3cccc(CC(=O)O)c3)cc2)Oc2ccccc21	10.1016/j.bmc.2011.08.007
		44303709	203200	0	None	-870	3	Mouse	5.3	pKi	=	5.3	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	470	13	3	7	3.3	CSCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		CHEMBL64338	203200	0	None	-870	3	Mouse	5.3	pKi	=	5.3	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	470	13	3	7	3.3	CSCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		59465581	144112	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3903611	144112	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	11	2	4	6.1	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		44455236	95475	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	373	11	2	3	3.8	CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		CHEMBL257217	95475	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from human EP2 receptorDisplacement of [3H]PGE2 from human EP2 receptor	ChEMBL	373	11	2	3	3.8	CCCCCC[C@H](O)/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.11.020
		21974448	66963	0	None	-53	4	Mouse	6.3	pKi	=	6.3	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	429	8	1	5	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL186735	66963	0	None	-53	4	Mouse	6.3	pKi	=	6.3	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	429	8	1	5	4.7	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCCOc2ccccc2)cc1	10.1016/j.bmcl.2004.07.039
		11155228	66106	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
		CHEMBL183919	66106	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1c(Cl)cccc1Cl	10.1016/j.bmcl.2004.11.051
		44419347	82775	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
		CHEMBL217988	82775	0	None	-1778	4	Human	5.3	pKi	=	5.3	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	452	8	1	2	7.2	Cc1ccc(OCc2c(Cl)cccc2Cl)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
		10298293	94167	0	None	-426	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249538	94167	0	None	-426	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	460	9	2	4	3.1	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Br)c2)cc1	10.1016/j.bmcl.2007.09.074
		52944193	16533	0	None	-63	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237295	16533	0	None	-63	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		21362905	171307	0	None	-8	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	6.9	CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
		CHEMBL446098	171307	0	None	-8	4	Human	5.3	pKi	=	5.3	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	428	8	1	3	6.9	CC(Cc1ccccc1-c1csc(-c2ccccc2OCc2ccccc2)c1)C(=O)O	10.1016/s0960-894x(03)00794-7
		58932683	75287	0	None	-354	3	Mouse	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
		CHEMBL2037289	75287	0	None	-354	3	Mouse	7.3	pKi	=	7.3	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	549	10	2	8	5.2	Cc1ccc2nc(-c3cccc(C[C@H](O)/C=C/[C@H]4CCC(=O)N4CCSc4nc(C(=O)O)cs4)c3)oc2c1	10.1016/j.bmc.2012.04.008
		44444716	154837	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	484	12	1	3	5.4	CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1	10.1016/j.bmcl.2007.09.074
		CHEMBL400447	154837	0	None	-12	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	484	12	1	3	5.4	CC(CCN1CCC(=O)N1CCc1ccc(C(=O)O)cc1)Cc1cccc(CCc2ccccc2)c1	10.1016/j.bmcl.2007.09.074
		10295421	94197	0	None	-316	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	416	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249744	94197	0	None	-316	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	416	9	2	4	3.0	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2007.09.074
		44234032	147925	0	None	-81	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	415	8	1	4	5.0	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1	10.1021/acs.jmedchem.6b00871
		CHEMBL3933704	147925	0	None	-81	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	415	8	1	4	5.0	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2cccc(F)c2)CC1	10.1021/acs.jmedchem.6b00871
		11165749	165959	0	None	-20	3	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL425167	165959	0	None	-20	3	Mouse	5.2	pKi	=	5.2	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	409	9	1	5	4.8	CCCCOc1ccc(C(=O)n2c(C)c(CCC(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		44520990	199853	0	None	-6	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	410	6	2	4	5.3	Cc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
		CHEMBL594423	199853	0	None	-6	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	410	6	2	4	5.3	Cc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
		11855867	145983	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3918349	145983	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		11855867	145983	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3918349	145983	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	389	8	2	5	3.6	CCC(O)c1ccc(N2C(=O)CC[C@@H]2COCc2ccc(C(=O)O)s2)cc1	nan
		44304403	169097	0	None	-16	4	Mouse	7.2	pKi	=	7.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	420	12	3	4	3.8	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
		CHEMBL439934	169097	0	None	-16	4	Mouse	7.2	pKi	=	7.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	420	12	3	4	3.8	COCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)C[C@@H](F)[C@@H]2C/C=C/CCCC(=O)O)c1	10.1016/s0960-894x(01)00365-1
		44290314	173974	0	None	-5754	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	403	10	2	4	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1	10.1016/j.bmcl.2004.01.063
		CHEMBL45418	173974	0	None	-5754	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	403	10	2	4	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1ccc(C(F)(F)F)o1	10.1016/j.bmcl.2004.01.063
		44320272	206262	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	507	10	1	5	5.9	O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL86886	206262	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	507	10	1	5	5.9	O=C(Cc1ccccc1-c1ccc(CSCCc2ccccc2)cc1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		24952929	2554	42	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
		4041	2554	42	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
		CHEMBL597997	2554	42	None	-9332	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
		10295336	201446	0	None	-53	4	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	415	8	1	3	4.7	O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		CHEMBL604897	201446	0	None	-53	4	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	415	8	1	3	4.7	O=C(O)/C=C/c1ccc(CN2CCCC2=O)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		44290266	161708	0	None	-8	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	353	12	3	4	2.3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O	10.1016/j.bmcl.2004.01.063
		CHEMBL413509	161708	0	None	-8	4	Human	8.2	pKi	=	8.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	353	12	3	4	2.3	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)N1C/C=C/CCCC(=O)O	10.1016/j.bmcl.2004.01.063
		44394380	125429	0	None	-6	4	Mouse	7.2	pKi	=	7.2	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL364593	125429	0	None	-6	4	Mouse	7.2	pKi	=	7.2	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	457	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2COc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		44442337	94007	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	381	8	1	2	5.0	C/C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)CC1CCCC1	10.1016/j.bmcl.2007.05.025
		CHEMBL248678	94007	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	381	8	1	2	5.0	C/C(=C/C=C/[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)CC1CCCC1	10.1016/j.bmcl.2007.05.025
		44442331	94490	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		CHEMBL251505	94490	0	None	-15	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C(C)=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		10278907	64418	0	None	-138	3	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
		CHEMBL1813121	64418	0	None	-138	3	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	504	6	1	6	5.2	Cc1c(CC(=O)O)c2ccccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1Cl	10.1016/j.bmc.2011.06.014
		59465570	143259	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL3896693	143259	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	392	13	2	2	6.6	CCCCCC(O)c1ccc([C@H]2CC[C@@H](F)[C@@H]2CCCCCCC(=O)O)cc1	nan
		134147021	150024	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
		CHEMBL3950412	150024	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	414	13	2	3	6.9	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)O)s1	nan
		10204257	94169	0	None	-104	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	9	2	4	3.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249540	94169	0	None	-104	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	9	2	4	3.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(C(F)(F)F)c2)cc1	10.1016/j.bmcl.2007.09.074
		44219292	112582	38	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
		CHEMBL3301604	112582	38	None	-204	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hrDisplacement of [3H]-PGE2 from recombinant human EP2 receptor expressed in HEK293 cell membranes incubated for 1 hr	ChEMBL	431	8	1	4	5.5	O=C(O)COC[C@H]1CC[C@H](COC(=O)N(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1021/acs.jmedchem.6b00871
		57400087	71302	0	None	-2	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	8	2	3	4.0	O=C(O)CCc1cccc(N2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1957431	71302	0	None	-2	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	413	8	2	3	4.0	O=C(O)CCc1cccc(N2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(Cl)c2)c1	10.1016/j.bmc.2012.02.018
		57893916	75155	0	None	-1288	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	454	12	2	5	3.8	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccccn2)c1	10.1016/j.bmc.2012.04.008
		CHEMBL2036309	75155	0	None	-1288	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	454	12	2	5	3.8	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2ccccn2)c1	10.1016/j.bmc.2012.04.008
		56672019	64814	0	None	-7	4	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1	10.1016/j.bmc.2011.08.007
		CHEMBL1819612	64814	0	None	-7	4	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	460	7	2	5	4.5	Cc1cc(CC(=O)O)cc(NC(=O)c2ccc(OC[C@@H]3CN(C)c4ccccc4O3)cc2C)c1	10.1016/j.bmc.2011.08.007
		8541	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		9824353	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		CHEMBL292964	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/s0960-894x(01)00365-1
		8541	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
		9824353	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
		CHEMBL292964	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Binding affinity to mouse EP2 receptor by competitive binding assayBinding affinity to mouse EP2 receptor by competitive binding assay	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1021/jm9018756
		8541	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
		9824353	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
		CHEMBL292964	2944	2	None	-1548	4	Mouse	6.2	pKi	=	6.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	436	13	3	6	2.8	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O)O	10.1016/j.bmc.2011.12.009
		10221497	94139	0	None	-91	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249342	94139	0	None	-91	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
		10272306	154836	0	None	-173	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	400	9	2	4	2.5	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL400446	154836	0	None	-173	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	400	9	2	4	2.5	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(F)c2)cc1	10.1016/j.bmcl.2007.09.074
		71452690	78625	0	None	15	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	400	9	1	4	5.1	c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1	10.1016/s0960-894x(02)00518-8
		CHEMBL2112332	78625	0	None	15	4	Human	7.2	pKi	=	7.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	400	9	1	4	5.1	c1ccc(CCSCc2ccc(-c3ccccc3CCc3nnn[nH]3)cc2)cc1	10.1016/s0960-894x(02)00518-8
		52950151	16537	0	None	3	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237299	16537	0	None	3	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1.Cc1cccc(C/C=C/c2cccc(/C=C/C(=O)O)c2)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		22008967	83149	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
		CHEMBL218228	83149	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
		22008966	83150	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
		CHEMBL218229	83150	0	None	-2691	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	439	8	1	5	4.5	COc1ccc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)cc1	10.1016/j.bmcl.2006.08.025
		13230981	35067	0	None	-1122	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	339	13	2	3	3.5	CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
		CHEMBL14334	35067	0	None	-1122	3	Human	5.2	pKi	=	5.2	Binding	Binding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAsBinding affinity towards EP2 receptor expressed in HEK293 ebna cells recombinantly expressing the corresponding human prostanoid cDNAs	ChEMBL	339	13	2	3	3.5	CCCCCC(O)/C=C/[C@H]1CCC(=O)N1CCCCCCC(=O)O	10.1016/s0960-894x(03)00042-8
		10348006	75290	0	None	-338	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	569	10	2	8	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
		CHEMBL2037292	75290	0	None	-338	3	Mouse	7.2	pKi	=	7.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	569	10	2	8	5.5	O=C(O)c1csc(SCCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)Cc2cccc(-c3nc4cc(Cl)ccc4o3)c2)n1	10.1016/j.bmc.2012.04.008
		52943000	16535	0	None	-26	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237297	16535	0	None	-26	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	740	16	2	4	11.2	O=C(O)/C=C/c1ccccc1/C=C/Cc1ccccc1OCc1ccccc1.O=C(O)/C=C/c1ccccc1C/C=C\c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		10319835	69367	0	None	-16982	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	417	13	2	3	4.9	CCCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		CHEMBL1929547	69367	0	None	-16982	3	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	417	13	2	3	4.9	CCCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=S)N2CCCCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		44520991	199702	0	None	-7	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	426	7	2	5	5.0	COc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
		CHEMBL593260	199702	0	None	-7	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	426	7	2	5	5.0	COc1ccc(/C=C/C(=O)O)c(OCCC2(C)CCc3c(C)c(O)c(C)c(C)c3O2)c1	10.1016/j.bmc.2009.08.007
		44289977	162759	0	None	-478	2	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	413	10	2	3	4.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
		CHEMBL417171	162759	0	None	-478	2	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	413	10	2	3	4.3	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(C(F)(F)F)c1	10.1016/j.bmcl.2004.01.063
		12003887	71299	0	None	-776	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	411	11	2	4	3.4	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(Cl)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1957308	71299	0	None	-776	2	Mouse	5.2	pKi	=	5.2	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	411	11	2	4	3.4	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(Cl)c1	10.1016/j.bmc.2012.02.018
		67078970	129199	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	416	6	3	5	4.4	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
		CHEMBL3670655	129199	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	416	6	3	5	4.4	COC(=O)c1ccc(CNC(=O)c2[nH]c(-c3ccoc3)cc2-c2ccc(O)cc2)cc1	nan
		25114442	3061	56	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.1021/acs.jmedchem.1c00816
		5817	3061	56	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.1021/acs.jmedchem.1c00816
		CHEMBL3286797	3061	56	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.1021/acs.jmedchem.1c00816
		DB12024	3061	56	None	-	1	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constantBinding affinity to human EP2 receptor expressed in CHO cells assessed as inhibition constant	ChEMBL	409	6	1	4	3.6	COc1ccc2c(c1)ccc(c2)OCC1(CN(C1)C(=O)c1ccc(cc1)F)C(=O)O	10.1021/acs.jmedchem.1c00816
		59465571	146285	0	None	21	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		CHEMBL3920796	146285	0	None	21	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	386	12	2	3	5.6	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2C/C=C\CCCC(=O)O)cc1	nan
		59465600	151698	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL3964261	151698	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.3	CCCCC(O)Cc1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
		21362845	106903	0	None	-630	4	Human	4.2	pKi	=	4.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	556	7	1	5	7.3	O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		CHEMBL314616	106903	0	None	-630	4	Human	4.2	pKi	=	4.2	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	556	7	1	5	7.3	O=C(/C=C/c1ccccc1-c1cccc(/C=C/c2ccc3ccc(Cl)cc3n2)c1)NS(=O)(=O)c1cccs1	10.1016/s0960-894x(02)00518-8
		52943002	16539	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	716	14	2	4	11.1	Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237301	16539	0	None	-2	4	Human	5.2	pKi	=	5.2	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	716	14	2	4	11.1	Cc1cccc(/C=C\Cc2ccccc2C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		67245477	144883	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
		CHEMBL3909989	144883	0	None	-	1	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	428	13	1	4	7.0	CCCCCC(O)c1ccc([C@H]2CC[C@@H](Cl)[C@@H]2CCCCCCC(=O)OC)s1	nan
		44289921	164371	0	None	-9332	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	365	11	2	3	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1	10.1016/j.bmcl.2004.01.063
		CHEMBL42129	164371	0	None	-9332	3	Human	4.2	pKi	=	4.2	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	365	11	2	3	3.9	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)CC1CCCCC1	10.1016/j.bmcl.2004.01.063
		57893891	75159	0	None	-1995	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	510	12	2	6	5.0	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3s2)c1	10.1016/j.bmc.2012.04.008
		CHEMBL2036313	75159	0	None	-1995	2	Mouse	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	510	12	2	6	5.0	O=C(O)CCCSCCN1C(=O)CC[C@@H]1/C=C/[C@@H](O)Cc1cccc(-c2nc3ccccc3s2)c1	10.1016/j.bmc.2012.04.008
		24952929	2554	42	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
		4041	2554	42	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
		CHEMBL597997	2554	42	None	-11481	5	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from rat EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	473	6	2	3	6.1	OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1c(C)sc(c1Cc1ccc(cc1)C(F)(F)F)C	10.1021/jm901771h
		1892	747	20	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
		25886893	747	20	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
		CHEMBL1628262	747	20	None	-2	9	Human	7.1	pKi	=	7.1	Binding	Binding affinity to EP2 receptor (unknown origin) by competitive binding assayBinding affinity to EP2 receptor (unknown origin) by competitive binding assay	ChEMBL	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1021/jm401431x
		44304181	203273	0	None	12	2	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL64663	203273	0	None	12	2	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	394	13	3	4	4.3	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		9965922	63877	0	None	-724	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	294	5	2	2	4.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O	10.1016/j.bmcl.2004.11.051
		CHEMBL180389	63877	0	None	-724	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	294	5	2	2	4.1	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1O	10.1016/j.bmcl.2004.11.051
		24765153	184529	0	None	-11481	8	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
		CHEMBL484778	184529	0	None	-11481	8	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	434	5	1	4	6.6	CC(C)c1nccc2c1c(Sc1ccc(Cl)c(Cl)c1)c1n2CC[C@H]1CC(=O)O	10.1016/j.bmcl.2009.03.010
		9910141	100875	0	None	-1513	3	Mouse	5.1	pKi	=	5.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	11	4	6	2.7	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
		CHEMBL293647	100875	0	None	-1513	3	Mouse	5.1	pKi	=	5.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	422	11	4	6	2.7	Cc1cc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)O)ccc1O	10.1016/s0960-894x(01)00365-1
		118517485	142750	0	None	-50	2	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
		CHEMBL3892492	142750	0	None	-50	2	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
		24952580	200562	0	None	-575	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
		CHEMBL599052	200562	0	None	-575	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	467	6	2	3	6.5	C[C@H](NC(=O)c1c(Cl)sc(Cl)c1Cc1cccc(Cl)c1)c1ccc(C(=O)O)cc1	10.1021/jm901771h
		10452108	94008	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	375	7	1	2	4.6	C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1	10.1016/j.bmcl.2007.05.025
		CHEMBL248679	94008	0	None	-25	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	375	7	1	2	4.6	C/C(=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1)c1ccccc1	10.1016/j.bmcl.2007.05.025
		44304388	203152	0	None	-151	5	Mouse	7.1	pKi	=	7.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O	10.1016/s0960-894x(01)00365-1
		CHEMBL64187	203152	0	None	-151	5	Mouse	7.1	pKi	=	7.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)O	10.1016/s0960-894x(01)00365-1
		11440167	84718	0	None	-75	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	371	9	2	3	3.4	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
		CHEMBL222782	84718	0	None	-75	3	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human EP2 receptorBinding affinity to human EP2 receptor	ChEMBL	371	9	2	3	3.4	O=C(O)c1ccc(CCN2C(=O)CC[C@@H]2/C=C/[C@@H](O)CCC2CCC2)cc1	10.1021/jm049290a
		44444722	94256	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
		CHEMBL250153	94256	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	402	11	2	4	3.5	CCCC1(C(O)CCCN2CCC(=O)N2CCc2ccc(C(=O)O)cc2)CCC1	10.1016/j.bmcl.2007.09.074
		52945294	16547	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237317	16547	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		52945294	16547	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
		CHEMBL1237317	16547	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	800	18	2	6	11.3	COc1cc(/C=C\Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1.COc1cc(C/C=C/c2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
		10111602	83228	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	400	9	1	3	5.6	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
		CHEMBL218626	83228	0	None	-95	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	400	9	1	3	5.6	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)O)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
		22990263	16793	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	292	3	1	1	4.8	O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL124574	16793	0	None	-4	3	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	292	3	1	1	4.8	O=C(O)/C=C/c1ccccc1-c1ccc(Cl)c(Cl)c1	10.1016/s0960-894x(03)00794-7
		10410111	102841	0	None	-398	3	Mouse	6.1	pKi	=	6.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		CHEMBL305568	102841	0	None	-398	3	Mouse	6.1	pKi	=	6.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	424	11	3	6	2.7	Cc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		44304009	100736	0	None	-1479	3	Mouse	5.1	pKi	=	5.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	482	15	3	7	3.3	CCCOCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		CHEMBL292717	100736	0	None	-1479	3	Mouse	5.1	pKi	=	5.1	Binding	Evaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptorEvaluated for its competitive binding affinity towards mouse Prostanoid EP2 receptor in CHO cells expressing prostanoid receptor	ChEMBL	482	15	3	7	3.3	CCCOCc1cccc(C[C@H](O)/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2SCCCSCC(=O)O)c1	10.1016/s0960-894x(01)00364-x
		11210487	64294	0	None	177	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	356	7	1	2	5.5	O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL181035	64294	0	None	177	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	356	7	1	2	5.5	O=C(O)/C=C/c1ccccc1/C=C/c1ccccc1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		16725337	149601	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3947001	149601	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 minsDisplacement of [3H]-PGE2 from human EP2 receptor expressed in HEK293 cells after 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		16725337	149601	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		CHEMBL3947001	149601	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	443	12	2	4	6.0	CCCCCCC(O)c1ccc(N2C(=O)CC[C@@H]2CCCc2ccc(C(=O)O)s2)cc1	nan
		24953625	201532	0	None	-323	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1	10.1021/jm901771h
		CHEMBL605330	201532	0	None	-323	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation countingDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293-EBNA cells by scintillation counting	ChEMBL	461	6	2	3	6.2	Cc1sc(C)c(C(=O)N[C@@H](C)c2ccc(C(=O)O)cc2)c1Cc1cccc(C(F)(F)F)c1	10.1021/jm901771h
		10302378	82779	0	None	-6606	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	539	9	1	5	6.6	O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
		CHEMBL217991	82779	0	None	-6606	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	539	9	1	5	6.6	O=C(/C=C/c1ccccc1Cc1ccc2cc(OCc3ccccc3)ccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
		22009006	141564	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
		CHEMBL384878	141564	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1/C=C/Cc1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
		9953337	141660	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
		CHEMBL385396	141660	0	None	-1584	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	409	7	1	4	4.5	O=C(/C=C/c1ccccc1C/C=C/c1ccccc1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
		25003075	6838	18	None	-28183	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting	ChEMBL	478	6	2	3	5.8	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.04.065
		CHEMBL1084009	6838	18	None	-28183	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting	ChEMBL	478	6	2	3	5.8	O=C(O)c1ccc(C2(NC(=O)c3cccc4ccn(Cc5ccc(C(F)(F)F)cc5)c34)CC2)cc1	10.1016/j.bmcl.2010.04.065
		10247632	77991	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		CHEMBL2096894	77991	0	None	-1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	355	9	1	2	4.6	CCCC/C=C(C)/C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		10178073	16559	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/s0960-894x(03)00794-7
		CHEMBL123794	16559	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/s0960-894x(03)00794-7
		9944231	18035	0	None	-10	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	302	5	1	1	5.0	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL126472	18035	0	None	-10	4	Human	5.1	pKi	=	5.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	302	5	1	1	5.0	O=C(O)CCc1ccccc1-c1cccc(-c2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		10178073	16559	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL123794	16559	0	None	-1148	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		12112238	118071	0	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	406	7	1	2	6.7	O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		CHEMBL340501	118071	0	None	-10	4	Human	6.1	pKi	=	6.1	Binding	Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.Affinity at human Prostanoid EP2 receptor in the human embryonic kidney (HEK) 293 cell line.	ChEMBL	406	7	1	2	6.7	O=C(O)/C=C/c1ccccc1-c1cccc(-c2ccccc2OCc2ccccc2)c1	10.1016/s0960-894x(03)00794-7
		44444715	94198	0	None	-25	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	12	2	4	3.7	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(CCC3CC3)c2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249745	94198	0	None	-25	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	450	12	2	4	3.7	O=C(O)c1ccc(CCN2C(=O)CCN2CCC(O)Cc2cccc(CCC3CC3)c2)cc1	10.1016/j.bmcl.2007.09.074
		57398585	69470	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933721	69470	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
		57398585	69470	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1933721	69470	0	None	-6	2	Mouse	7.1	pKi	=	7.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	414	9	2	5	3.2	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCCc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
		56834112	69347	0	None	-1071	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	421	13	2	5	2.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		CHEMBL1929527	69347	0	None	-1071	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counterDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter	ChEMBL	421	13	2	5	2.9	COCc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSCCCC(=O)O)c1	10.1016/j.bmc.2011.12.009
		44290271	179048	0	None	-204	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2cccc(Cl)c2)c1	10.1016/j.bmcl.2004.01.063
		CHEMBL47138	179048	0	None	-204	2	Human	4.1	pKi	=	4.1	Binding	Binding affinity was determined against prostanoid EP2 receptorBinding affinity was determined against prostanoid EP2 receptor	ChEMBL	455	11	2	3	5.6	O=C(O)CCCCCCN1C(=O)CC[C@@H]1/C=C/C(O)c1cccc(-c2cccc(Cl)c2)c1	10.1016/j.bmcl.2004.01.063
		52944193	16533	0	None	-63	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237295	16533	0	None	-63	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	768	16	2	4	11.9	Cc1cccc(/C=C/Cc2ccccc2/C=C/C(=O)O)c1OCc1ccccc1.Cc1cccc(C/C=C/c2ccccc2/C=C/C(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		44419374	82995	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
		CHEMBL218123	82995	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
		44419379	137863	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
		CHEMBL376053	137863	0	None	-95	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	384	8	1	2	5.9	Cc1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2006.08.025
		44320388	206408	0	None	-56	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	536	11	2	6	5.8	Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		CHEMBL87797	206408	0	None	-56	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity at human Prostanoid EP2 receptor.Binding affinity at human Prostanoid EP2 receptor.	ChEMBL	536	11	2	6	5.8	Cc1cccc(OCCCOc2ccc(-c3ccccc3CNC(=O)NS(=O)(=O)c3cccs3)cc2)c1	10.1016/s0960-894x(02)00518-8
		9954562	84137	0	None	-478	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	433	6	1	4	5.0	O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
		CHEMBL220802	84137	0	None	-478	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	433	6	1	4	5.0	O=C(/C=C/c1ccccc1Cc1ccc2ccccc2c1)NS(=O)(=O)c1cccs1	10.1016/j.bmcl.2006.08.025
		138	3081	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
		1882	3081	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
		5280723	3081	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
		CHEMBL495	3081	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
		DB00770	3081	88	None	-19	18	Mouse	7.1	pKi	=	7.1	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1016/s0960-894x(01)00359-6
		52945423	16541	0	None	-33	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	824	18	2	6	11.6	CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2004.11.051
		CHEMBL1237303	16541	0	None	-33	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	824	18	2	6	11.6	CC(=O)c1ccc(OCc2ccccc2)c(/C=C/Cc2ccccc2/C=C/C(=O)O)c1.CC(=O)c1ccc(OCc2ccccc2)c(C/C=C/c2ccccc2/C=C/C(=O)O)c1	10.1016/j.bmcl.2004.11.051
		22009008	83157	0	None	-5495	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
		CHEMBL218280	83157	0	None	-5495	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(/C=C/Cc2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
		22009004	141751	0	None	-2884	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
		CHEMBL385955	141751	0	None	-2884	4	Human	5.1	pKi	=	5.1	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	545	11	1	6	6.1	COc1cc(C/C=C/c2ccccc2/C=C/C(=O)NS(=O)(=O)c2cccs2)ccc1OCc1ccccc1	10.1016/j.bmcl.2006.08.025
		132836	59695	23	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
		CHEMBL1722929	59695	23	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 minsDisplacement of [3H]PGE2 from from human EP2 receptor expressed in HEK293 cells at pH 7.3 membranes incubated for 60 mins	ChEMBL	388	13	2	3	5.8	CCCCCC(O)c1ccc([C@H]2CCC(=O)[C@@H]2CCCCCCC(=O)O)cc1	nan
		44442332	94527	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		CHEMBL251709	94527	0	None	-3	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cellsDisplacement of [3H]PGE2 from human EP2 receptor expressed in HEK293 cells	ChEMBL	341	9	1	2	4.2	CCCC/C=C\C=C\[C@H]1CCC(=O)N1CCc1ccc(C(=O)O)cc1	10.1016/j.bmcl.2007.05.025
		44393680	66345	0	None	-4	2	Mouse	5.1	pKi	=	5.1	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	367	7	1	5	4.2	CCCCOc1ccc(C(=O)n2cc(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		CHEMBL185087	66345	0	None	-4	2	Mouse	5.1	pKi	=	5.1	Binding	Binding affinity for mouse Prostanoid EP2 receptorBinding affinity for mouse Prostanoid EP2 receptor	ChEMBL	367	7	1	5	4.2	CCCCOc1ccc(C(=O)n2cc(C(=O)O)c3cc(OC)ccc32)cc1	10.1016/j.bmcl.2004.06.006
		84973026	129208	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	441	7	4	4	4.7	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2cccc(CC(=O)NO)c2)cc1	nan
		CHEMBL3670664	129208	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	441	7	4	4	4.7	COc1ccc(-c2cc(-c3ccccc3)[nH]c2C(=O)Nc2cccc(CC(=O)NO)c2)cc1	nan
		57894063	75165	0	None	-5	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
		CHEMBL2036319	75165	0	None	-5	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	524	11	2	7	4.8	COc1ccc(-c2cccc(C[C@H](O)/C=C/[C@H]3CCC(=O)N3CCSc3nc(C(=O)O)cs3)c2)cc1	10.1016/j.bmc.2012.04.008
		56835070	69471	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
		CHEMBL1933722	69471	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmcl.2011.10.109
		56835070	69471	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1933722	69471	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.02.018
		56835070	69471	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
		CHEMBL1933722	69471	0	None	-22	3	Mouse	8.0	pKi	=	8.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	432	9	2	6	3.4	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2nc(C(=O)O)cs2)c1	10.1016/j.bmc.2012.04.008
		84973025	129205	5	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccc(O)cc3)cc2-c2ccoc2)cc1	nan
		CHEMBL3670661	129205	5	None	-	1	Human	8.0	pKi	=	8.0	Binding	Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).Binding Assay: Measurement of EP2 receptor binding affinity was carried out according to the method of Abramovitz et al. (Biochimica et Biophysica Acta, 1483, 285 (2000)). A test compound dissolved in dimethylsulfoxide and [3H]PGE2 (NET-428, available from PerkinElmer Inc.) (final concentration: 10 nM) were added to a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2, 1 mM EDTA) in which 10 μg of a membrane fraction (ES-562-M, available from Euroscreen S.A.) of HEK293 cells expressing human EP2 receptor had been suspended, followed by incubation at 30° C. for 60 minutes. The membrane fraction was recovered on glass fiber filter paper (GF/B, available from Whatman PLC) using a cell harvester (M30R, available from Brandel Inc.), and after washing with a buffer solution (10 mM MES-KOH (pH 6.0), 10 mM MgCl2), radioactivity was measured with a liquid scintillation analyzer (2000CA, available from Packard).	ChEMBL	417	6	5	5	3.7	O=C(NO)c1ccc(CNC(=O)c2[nH]c(-c3ccc(O)cc3)cc2-c2ccoc2)cc1	nan
		21974374	127247	0	None	-1	5	Mouse	7.1	pKi	=	7.1	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	5.0	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		CHEMBL365829	127247	0	None	-1	5	Mouse	7.1	pKi	=	7.1	Binding	Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2Ability to inhibit the binding of [3H]-PGD-2 radioligand to membranes of CHO cells stably expressing mouse Prostaglandin E receptor EP2	ChEMBL	455	6	1	5	5.0	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OCC2CCc3ccccc3O2)cc1	10.1016/j.bmcl.2004.07.039
		44304334	201576	0	None	-45	5	Mouse	7.0	pKi	=	7.0	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
		CHEMBL60555	201576	0	None	-45	5	Mouse	7.0	pKi	=	7.0	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	ChEMBL	372	13	3	5	3.0	CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CSCCCCC(=O)O	10.1016/s0960-894x(01)00365-1
		57396659	71301	0	None	-114	3	Mouse	7.0	pKi	=	7.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	431	9	2	5	4.0	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
		CHEMBL1957430	71301	0	None	-114	3	Mouse	7.0	pKi	=	7.0	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	431	9	2	5	4.0	Cc1cccc(C[C@H](O)/C=C/[C@H]2CCC(=O)N2CCSc2ccc(C(=O)O)s2)c1	10.1016/j.bmc.2012.02.018
		44304199	100817	0	None	-	1	Mouse	7.0	pKi	=	7.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		CHEMBL293242	100817	0	None	-	1	Mouse	7.0	pKi	=	7.0	Binding	Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.Binding affinity towards mouse Prostanoid EP2 receptor expressed in CHO cells.	ChEMBL	392	12	3	4	4.0	CCCC1([C@@H](O)C/C=C/C2[C@H](O)CC(=O)[C@@H]2C/C=C/CCCC(=O)O)CCC1	10.1016/s0960-894x(01)00359-6
		44444719	94226	0	None	-67	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
		CHEMBL249952	94226	0	None	-67	2	Human	5.0	pKi	=	5.0	Binding	Binding affinity at human prostaglandin EP2 receptorBinding affinity at human prostaglandin EP2 receptor	ChEMBL	382	9	2	4	2.4	O=C(O)c1ccc(CCN2C(=O)CCN2CC[C@@H](O)Cc2ccccc2)cc1	10.1016/j.bmcl.2007.09.074
		10273914	199672	0	None	-70	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		CHEMBL593041	199672	0	None	-70	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	424	9	1	3	6.1	O=C(O)/C=C/c1ccc(COc2ccccc2)cc1OCCc1ccc2ccccc2c1	10.1016/j.bmc.2009.08.007
		46230201	200616	0	None	-436	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
		CHEMBL599355	200616	0	None	-436	3	Mouse	5.0	pKi	=	5.0	Binding	Displacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation countingDisplacement of [3H]PGE2 from mouse EP2 receptor expressed in CHO cells by liquid scintillation counting	ChEMBL	453	9	2	3	5.9	C[C@H](NC(=O)c1cc(COc2ccccc2)ccc1CCC(=O)O)c1cccc2ccccc12	10.1016/j.bmc.2009.11.023
		118517485	142750	0	None	-50	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
		CHEMBL3892492	142750	0	None	-50	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	396	8	2	3	4.2	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)cc2)cc1	nan
		118517490	153155	0	None	-125	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
		CHEMBL3976710	153155	0	None	-125	2	Human	5.0	pKi	=	5.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	414	8	2	3	4.4	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2ccc(F)c(F)c2)cc1	nan
		9865111	63865	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL180343	63865	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1cccc(CCCc2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		44419350	84142	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1	10.1016/j.bmcl.2006.08.025
		CHEMBL220820	84142	0	None	-14	4	Human	6.0	pKi	=	6.0	Binding	Binding affinity to EP2 receptorBinding affinity to EP2 receptor	ChEMBL	388	10	1	2	5.8	Cc1ccc(OCc2ccccc2)c(CCCc2ccccc2CCC(=O)O)c1	10.1016/j.bmcl.2006.08.025
		118517359	144396	0	None	-114	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
		CHEMBL3906016	144396	0	None	-114	2	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations wRadioligand Binding Assay: The cell homogenate was centrifuged at 19000 r.p.m. for 20 min at 4° C. using a Beckman Ti-60 rotor. The resultant pellet was resuspended in TME buffer to give a final 1 mg/ml protein concentration, as determined by Biorad assay. Radioligand binding competition assays vs. [3H-]17-phenyl PGF2a , (5 nM) were performed in a 100 μl volume for 60 min. Binding reactions were started by adding plasma membrane fraction. The reaction was terminated by the addition of 4 ml ice-cold TRIS-HCl buffer and rapid filtration through glass fiber GF/B filters using a Brandel cell harvester. The filters were washed 3 times with ice-cold buffer and oven dried for one hour. [3H-] PGE2 (specific activity 180 Ci mmol) was used as the radioligand for EP receptors. [3H] 17-phenyl PGF2a, was employed for FP receptor binding studies. Binding studies employing EP1, EP2, EP4 and FP receptors were performed in duplicate in at least three separate experiments. A 200 μl assay volume was used. Incubations w	ChEMBL	456	8	2	3	4.8	O=C(O)c1ccc(CC[C@H]2C(=O)CC[C@@H]2/C=C/C(O)Cc2cccc(Br)c2)cc1	nan
		10116114	125886	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		CHEMBL364841	125886	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.06.014
		10116114	125886	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.08.007
		CHEMBL364841	125886	0	None	-28	8	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]PGE2 from mouse prostaglandin EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	ChEMBL	470	6	1	6	4.5	Cc1cc2c(CC(=O)O)cccc2n1C(=O)c1ccc(OC[C@@H]2CN(C)c3ccccc3O2)cc1	10.1016/j.bmc.2011.08.007
		44390806	64078	0	None	-24	3	Human	6.0	pKi	=	6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	8	1	2	5.9	Cc1cccc(C2CC2c2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		CHEMBL180752	64078	0	None	-24	3	Human	6.0	pKi	=	6	Binding	Binding affinity for human prostanoid EP2 receptorBinding affinity for human prostanoid EP2 receptor	ChEMBL	386	8	1	2	5.9	Cc1cccc(C2CC2c2ccccc2CCC(=O)O)c1OCc1ccccc1	10.1016/j.bmcl.2004.11.051
		1883	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		1883	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		1916	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		1916	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		5280360	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		5280360	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		913	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		913	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		CHEMBL548	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		CHEMBL548	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		DB00917	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		DB00917	3082	75	None	-6	24	Human	7.8	pKd	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		1883	3082	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
		1916	3082	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
		5280360	3082	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
		913	3082	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
		CHEMBL548	3082	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
		DB00917	3082	75	None	-15	24	Mouse	7.7	pKd	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14699136
		1883	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
		1883	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		1916	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
		1916	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		5280360	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
		5280360	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		913	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
		913	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		CHEMBL548	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
		CHEMBL548	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		DB00917	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9440134
		DB00917	3082	75	None	-7	24	Rat	8.1	pKd	None	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		138	3081	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		1882	3081	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		5280723	3081	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		CHEMBL495	3081	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		DB00770	3081	88	3H-PGE2	-19	18	Mouse	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		None	216046	0	3H-PGE2	-66	3	Mouse	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	350	11	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=C2)CCCCC(=O)O)O)O	None
		5090	15561	106	Functional	-1348	30	Dog	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		5090	15561	106	Functional	-35	30	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	Functional	-1348	30	Dog	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	Functional	-35	30	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		5311035	97803	29	3H-PGE2	4	9	Mouse	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	None
		CHEMBL271896	97803	29	3H-PGE2	4	9	Mouse	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	408	13	2	5	4.3	CCCC1([C@H](O)C/C=C/[C@H]2[C@H](O)CC(=O)[C@@H]2CCCCCCC(=O)OC)CCC1	None
		1883	3082	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		1916	3082	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		5280360	3082	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		913	3082	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		CHEMBL548	3082	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		DB00917	3082	75	3H-PGE2	-15	24	Mouse	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		1917	927	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
		5311044	927	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
		631	927	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
		CHEMBL160629	927	0	3H-PGE2	-22	9	Mouse	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
		89077401	216044	0	3H-PGE2	-144	12	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	360	8	3	3	3.5	CC#CCC(C)C(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
		133126726	216045	0	3H-PGE2	-151	14	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	350	10	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
		24868263	216045	0	3H-PGE2	-151	14	Mouse	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	350	10	3	3	4.1	CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)C2)O)O	None
		1440	2027	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		1909	2027	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		3715	2027	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		CHEMBL6	2027	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		DB00328	2027	119	Functional	-9	6	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		None	216043	0	3H-PGE2	-9	5	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	366	12	2	3	5.2	CCCCCC(C=CC1CC2CC(C1CC=CCCCC(=O)O)S2)O	None
		None	216049	0	3H-PGE2	-2	3	Mouse	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	512	11	2	4	4.6	C1CC2C(C(C1O2)CC=CCCCC(=O)O)C=CC(COC3=CC=C(C=C3)I)O	None
		1928	317	0	3H-PGE2	-3	3	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	None
		5310998	317	0	3H-PGE2	-3	3	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	None
		1817	2542	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		1936	2542	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		5282381	2542	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		CHEMBL606	2542	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		DB00929	2542	68	3H-PGE2	-6	12	Mouse	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		1440	2027	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		1440	2027	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		1909	2027	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		1909	2027	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		3715	2027	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		3715	2027	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		CHEMBL6	2027	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		CHEMBL6	2027	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		DB00328	2027	119	Functional	-38	6	Dog	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		DB00328	2027	119	Functional	-9	6	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		119461	320	72	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
		1896	320	72	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
		CHEMBL1317823	320	72	3H-PGE2	1	10	Mouse	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	None
		5090	15561	106	Functional	-35	30	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	Functional	-35	30	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		5090	15561	106	Functional	-35	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	Functional	-35	30	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		5077	3578	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
		7552	3578	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
		9913767	3578	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
		CHEMBL238804	3578	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
		DB11362	3578	79	None	1	4	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	496	12	1	7	3.9	O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	None
		1884	3083	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		5280363	3083	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		912	3083	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		CHEMBL815	3083	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		DB12789	3083	52	None	-36	22	Rat	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		138107701	187464	46	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		5311181	187464	46	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		CHEMBL494	187464	46	None	-5	15	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		138107701	187464	46	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		5311181	187464	46	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		CHEMBL494	187464	46	None	-5	15	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		1917	927	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
		5311044	927	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
		631	927	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
		CHEMBL160629	927	0	None	-22	9	Mouse	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	None
		138107701	187464	46	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		5311181	187464	46	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		CHEMBL494	187464	46	None	-5	15	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	360	8	3	3	3.5	CC#CCC(C)[C@H](O)/C=C/[C@@H]1[C@H]2C/C(=C/CCCC(=O)O)C[C@H]2C[C@H]1O	None
		1884	3083	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		5280363	3083	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		912	3083	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		CHEMBL815	3083	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		DB12789	3083	52	None	-37	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	None
		656511	217716	0	None	-1	7	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	539	6	3	8	-0.2	CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCN(C3=O)S(C)(=O)=O)C3=CC=CC=C3)C(=O)N2[C@H]1C(O)=O	None
		3356	2280	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
		4326	2280	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
		9867642	2280	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
		CHEMBL426559	2280	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
		DB11629	2280	73	None	-53	8	Human	8.2	pKi	=	8.2	Binding	Binding affinity to human EP2 receptor expressed in HEK293 cellsBinding affinity to human EP2 receptor expressed in HEK293 cells	Drug Central	435	5	1	4	4.4	OC(=O)C[C@H]1CCc2c1n(Cc1ccc(cc1)Cl)c1c2cc(cc1S(=O)(=O)C)F	None
		123619	216393	0	None	125	26	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		5090	15561	106	None	28	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	15561	106	None	28	30	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		1817	2542	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		1936	2542	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		5282381	2542	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		CHEMBL606	2542	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		DB00929	2542	68	None	-7	12	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	None
		138	3081	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		1882	3081	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		5280723	3081	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		CHEMBL495	3081	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		DB00770	3081	88	None	-19	18	Mouse	8.1	pKi	=	8.1	Binding	Affinity for mouse Prostanoid EP2 receptor expressed in CHO cellsAffinity for mouse Prostanoid EP2 receptor expressed in CHO cells	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		1883	3082	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		1916	3082	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		5280360	3082	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		913	3082	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		CHEMBL548	3082	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		DB00917	3082	75	None	-15	24	Mouse	8.1	pKi	=	8.1	Binding	Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation countingDisplacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counting	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		1440	2027	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		1909	2027	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		3715	2027	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		CHEMBL6	2027	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		DB00328	2027	119	None	3	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	357	4	1	4	3.9	COc1ccc2c(c1)c(CC(=O)O)c(n2C(=O)c1ccc(cc1)Cl)C	None
		138	3081	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		1882	3081	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		5280723	3081	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		CHEMBL495	3081	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		DB00770	3081	88	None	-8	18	Rat	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	None
		2720	3854	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
		5820	3854	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
		6918140	3854	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
		CHEMBL1237119	3854	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
		DB00374	3854	59	None	-1	6	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	None
		1883	3082	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		1916	3082	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		5280360	3082	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		913	3082	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		CHEMBL548	3082	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		DB00917	3082	75	None	-6	24	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human prostanoid EP2 receptor by radioligand displacement assayBinding affinity to human prostanoid EP2 receptor by radioligand displacement assay	Drug Central	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	None
		5852	2617	55	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
		9931891	2617	55	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
		CHEMBL239226	2617	55	None	-288	4	Human	5.2	pKi	=	5.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	17545310
		1895	2007	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
		6435378	2007	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
		CHEMBL236025	2007	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
		DB01088	2007	0	None	-125	16	Rat	5.9	pKi	=	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9537820
		1892	747	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
		1892	747	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
		25886893	747	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
		25886893	747	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
		CHEMBL1628262	747	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10462542
		CHEMBL1628262	747	20	None	-2	9	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10634944
		1883	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
		1883	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
		1883	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
		1916	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
		1916	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
		1916	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
		5280360	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
		5280360	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
		5280360	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
		913	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
		913	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
		913	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
		CHEMBL548	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
		CHEMBL548	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
		CHEMBL548	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
		DB00917	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10746663
		DB00917	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	14607240
		DB00917	3082	75	None	-15	24	Mouse	7.7	pKi	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9313928
		1883	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
		1883	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		1883	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		1916	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
		1916	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		1916	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		5280360	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
		5280360	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		5280360	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		913	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
		913	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		913	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		CHEMBL548	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
		CHEMBL548	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		CHEMBL548	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		DB00917	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10462542
		DB00917	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	10634944
		DB00917	3082	75	None	-6	24	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	16604093
		138	3081	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
		138	3081	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		1882	3081	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
		1882	3081	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		5280723	3081	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
		5280723	3081	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		CHEMBL495	3081	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
		CHEMBL495	3081	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		DB00770	3081	88	None	-19	18	Mouse	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
		DB00770	3081	88	None	-8	18	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		138	3081	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
		1882	3081	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
		5280723	3081	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
		CHEMBL495	3081	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
		DB00770	3081	88	None	-9	18	Human	8.0	pKi	=	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	8163486
		1883	3082	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		1916	3082	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		5280360	3082	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		913	3082	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		CHEMBL548	3082	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		DB00917	3082	75	None	-7	24	Rat	8.2	pKi	=	8.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O	9537820
		10110	3087	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	2	3	4.3	OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F	30341781
		59654860	3087	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	383	6	2	3	4.3	OC(=O)COc1cccc(c1)NC(=O)c1cc(ccc1F)c1cccc(c1)F	30341781
		2720	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
		2720	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
		5820	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
		5820	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
		6918140	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
		6918140	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
		CHEMBL1237119	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
		CHEMBL1237119	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
		DB00374	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	22480736
		DB00374	3854	59	None	-1	6	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	390	10	3	4	3.6	CCCCC[C@@H](CC[C@H]1[C@H](O)C[C@H]2[C@@H]1Cc1cccc(c1C2)OCC(=O)O)O	25542069
		10315	2926	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
		44230575	2926	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
		CHEMBL3707245	2926	28	None	-	1	Human	8.4	pKi	=	8.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	478	10	2	8	2.6	OC(=O)CNc1cccc(n1)CN(S(=O)(=O)c1cccnc1)Cc1ccc(cc1)n1cccn1	29332128
		1932	2942	5	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
		5311228	2942	5	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
		CHEMBL3286796	2942	5	None	-1	6	Mouse	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	410	12	3	3	4.8	C=CCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)C[C@H]([C@@H]1C/C=C\CCCC(=O)O)Cl)O	10746663
		1888	3900	29	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
		1974	3900	29	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
		5311493	3900	29	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
		CHEMBL521784	3900	29	None	-501	17	Human	4.9	pKi	None	4.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	10634944
		1817	2542	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
		1936	2542	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
		5282381	2542	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
		CHEMBL606	2542	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
		DB00929	2542	68	None	-7	12	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	382	13	2	5	4.0	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)OC)(O)C	10634944
		1881	3079	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		1891	3079	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		448457	3079	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		CHEMBL1235252	3079	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		DB02056	3079	0	None	-4570	21	Human	5.0	pKi	None	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		1888	3900	29	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
		1974	3900	29	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
		5311493	3900	29	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
		CHEMBL521784	3900	29	None	-316	17	Rat	5.1	pKi	None	5.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	12	2	3	4.3	CCCCC[C@@H](/C=C/[C@H]1[C@@H]2OC[C@H]([C@@H]1C/C=C\CCCC(=O)O)C2)O	9537820
		1881	3079	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		1891	3079	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		448457	3079	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		CHEMBL1235252	3079	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		DB02056	3079	0	None	-2290	21	Rat	5.3	pKi	None	5.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	352	12	3	4	3.3	CCCCC[C@@H](/C=C/[C@H]1C(=O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		1931	2946	0	None	-371	2	Mouse	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	14	1	4	4.6	CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC	10746663
		5311229	2946	0	None	-371	2	Mouse	5.4	pKi	None	5.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	14	1	4	4.6	CCCCC[C@@H](/C=C/[C@H]1[C@H](OC)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)OC	10746663
		1884	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		1884	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
		5280363	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		5280363	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
		912	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		912	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
		CHEMBL815	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		CHEMBL815	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
		DB12789	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10462542
		DB12789	3083	52	None	-37	22	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	10634944
		1884	3083	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		5280363	3083	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		912	3083	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		CHEMBL815	3083	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		DB12789	3083	52	None	-36	22	Rat	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	354	12	4	4	3.0	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O	9537820
		1913	2464	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10462542
		1913	2464	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10634944
		5311223	2464	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10462542
		5311223	2464	0	None	-15848	15	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	10634944
		1895	2007	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
		6435378	2007	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
		CHEMBL236025	2007	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
		DB01088	2007	0	None	-199	16	Human	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	10634944
		1933	2943	0	None	-199	3	Mouse	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	468	14	3	7	2.9	COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O	10746663
		5311230	2943	0	None	-199	3	Mouse	5.7	pKi	None	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	468	14	3	7	2.9	COCc1ccccc1CC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1SCCCSCC(=O)O)O	10746663
		1893	795	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
		5311242	795	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
		CHEMBL148319	795	0	None	-112	13	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	9313928
		1895	2007	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
		6435378	2007	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
		CHEMBL236025	2007	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
		DB01088	2007	0	None	-158	16	Mouse	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	360	8	3	3	3.5	CC#CCC([C@@H](/C=C/C1[C@H](O)C[C@H]2[C@@H]1C/C(=C/CCCC(=O)O)/C2)O)C	9313928
		1947	28	0	None	-39	3	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	8078484
		5283038	28	0	None	-39	3	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	8078484
		119461	320	72	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
		1896	320	72	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
		CHEMBL1317823	320	72	None	-3	10	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	10634944
		1917	927	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
		5311044	927	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
		631	927	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
		CHEMBL160629	927	0	None	-22	9	Mouse	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	6	3	4	2.2	CCC#CC[C@@H]([C@@H](C#C[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C/COCC(=O)O)/C2)O)C	9313928
		1913	2464	0	None	-8912	15	Rat	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	9537820
		5311223	2464	0	None	-8912	15	Rat	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	374	12	2	4	4.0	OC(=O)CCCCCC[C@@H]1[C@@H](/C=C/[C@H](COc2ccccc2)O)CCC1=O	9537820
		1928	317	0	None	-12	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	10462542
		5310998	317	0	None	-12	3	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	10462542
		1893	795	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
		5311242	795	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
		CHEMBL148319	795	0	None	-70	13	Human	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	10	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C/C(=C\CCCC(=O)O)/C2)O	10634944
		1934	2090	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
		5311244	2090	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
		CHEMBL4522827	2090	0	None	-63	3	Mouse	6.0	pKi	None	6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	350	11	3	3	4.1	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1CC(=C2)CCCCC(=O)O)O	9313928
		1912	26	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
		5283068	26	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
		CHEMBL1879970	26	0	None	-213	6	Rat	6.1	pKi	None	6.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	11	3	4	3.3	OC(=O)CCC/C=C\C[C@H]1C(=O)C[C@H]([C@@H]1/C=C/[C@H](CCc1ccccc1)O)O	9537820
		1930	3333	25	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
		9803828	3333	25	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
		CHEMBL303960	3333	25	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
		DB16315	3333	25	None	-999	3	Mouse	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	450	13	2	7	2.9	COCc1cccc(c1)C[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCSCCCC(=O)OC)O	11917107
		119461	320	72	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
		1896	320	72	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
		CHEMBL1317823	320	72	None	-1	10	Rat	6.3	pKi	None	6.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9537820
		119461	320	72	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
		1896	320	72	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
		CHEMBL1317823	320	72	None	1	10	Mouse	6.5	pKi	None	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	298	3	1	4	3.4	CC(Oc1ccc2c(c1)oc1c(c2=O)cc(cc1)C(=O)O)C	9313928
		1928	317	0	None	-3	3	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	9313928
		5310998	317	0	None	-3	3	Mouse	6.6	pKi	None	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	388	13	2	3	5.8	CCCCCC(c1ccc(cc1)C1CCC(=O)C1CCCCCCC(=O)O)O	9313928
		1947	28	0	None	-5	3	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	9537820
		5283038	28	0	None	-5	3	Rat	6.8	pKi	None	6.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	12	4	5	2.2	O[C@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)CCC[C@H](O)C	9537820
		1892	747	20	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		25886893	747	20	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		CHEMBL1628262	747	20	None	2	9	Rat	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	394	13	3	4	4.3	CCCC1(CCC1)[C@H](C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		1925	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
		5283055	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
		CHEMBL3246389	7	0	None	-39	6	Mouse	7.3	pKi	None	7.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9313928
		1925	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		5283055	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		CHEMBL3246389	7	0	None	-25	6	Rat	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	13	2	3	4.5	CCCCC[C@@H](/C=C/[C@H]1CCC(=O)[C@@H]1CCCCCCC(=O)O)O	9537820
		1935	2541	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
		6436406	2541	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
		CHEMBL1201377	2541	0	None	-3	3	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	368	13	3	4	3.9	CCCCC(C/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)(O)C	10634944
		1926	24	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928
		5283066	24	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928
		CHEMBL1221529	24	0	None	-8	3	Mouse	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	380	12	3	4	3.9	CCCCC([C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1C/C=C\CCCC(=O)O)O)(C)C	9313928

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Ligand source activities (1 row/activity)