LGR5 (lgr5_human)
FAMILY
Class A (Rhodopsin) Orphan receptors Class A orphans LGR5
GENE
LGR5 (GPR49, GPR67)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Leucine-rich repeat-containing G-protein coupled receptor 5, G-protein coupled receptor 49, G-protein coupled receptor 67, G-protein coupled receptor HG38
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
D
|
T
|
S
|
R
|
L
|
G
|
V
|
L
|
L
|
10 |
S
|
L
|
P
|
V
|
L
|
L
|
Q
|
L
|
A
|
T
|
20 |
G
|
G
|
S
|
S
|
P
|
R
|
S
|
G
|
V
|
L
|
30 |
L
|
R
|
G
|
C
|
P
|
T
|
H
|
C
|
H
|
C
|
40 |
E
|
P
|
D
|
G
|
R
|
M
|
L
|
L
|
R
|
V
|
50 |
D
|
C
|
S
|
D
|
L
|
G
|
L
|
S
|
E
|
L
|
60 |
P
|
S
|
N
|
L
|
S
|
V
|
F
|
T
|
S
|
Y
|
70 |
L
|
D
|
L
|
S
|
M
|
N
|
N
|
I
|
S
|
Q
|
80 |
L
|
L
|
P
|
N
|
P
|
L
|
P
|
S
|
L
|
R
|
90 |
F
|
L
|
E
|
E
|
L
|
R
|
L
|
A
|
G
|
N
|
100 |
A
|
L
|
T
|
Y
|
I
|
P
|
K
|
G
|
A
|
F
|
110 |
T
|
G
|
L
|
Y
|
S
|
L
|
K
|
V
|
L
|
M
|
120 |
L
|
Q
|
N
|
N
|
Q
|
L
|
R
|
H
|
V
|
P
|
130 |
T
|
E
|
A
|
L
|
Q
|
N
|
L
|
R
|
S
|
L
|
140 |
Q
|
S
|
L
|
R
|
L
|
D
|
A
|
N
|
H
|
I
|
150 |
S
|
Y
|
V
|
P
|
P
|
S
|
C
|
F
|
S
|
G
|
160 |
L
|
H
|
S
|
L
|
R
|
H
|
L
|
W
|
L
|
D
|
170 |
D
|
N
|
A
|
L
|
T
|
E
|
I
|
P
|
V
|
Q
|
180 |
A
|
F
|
R
|
S
|
L
|
S
|
A
|
L
|
Q
|
A
|
190 |
M
|
T
|
L
|
A
|
L
|
N
|
K
|
I
|
H
|
H
|
200 |
I
|
P
|
D
|
Y
|
A
|
F
|
G
|
N
|
L
|
S
|
210 |
S
|
L
|
V
|
V
|
L
|
H
|
L
|
H
|
N
|
N
|
220 |
R
|
I
|
H
|
S
|
L
|
G
|
K
|
K
|
C
|
F
|
230 |
D
|
G
|
L
|
H
|
S
|
L
|
E
|
T
|
L
|
D
|
240 |
L
|
N
|
Y
|
N
|
N
|
L
|
D
|
E
|
F
|
P
|
250 |
T
|
A
|
I
|
R
|
T
|
L
|
S
|
N
|
L
|
K
|
260 |
E
|
L
|
G
|
F
|
H
|
S
|
N
|
N
|
I
|
R
|
270 |
S
|
I
|
P
|
E
|
K
|
A
|
F
|
V
|
G
|
N
|
280 |
P
|
S
|
L
|
I
|
T
|
I
|
H
|
F
|
Y
|
D
|
290 |
N
|
P
|
I
|
Q
|
F
|
V
|
G
|
R
|
S
|
A
|
300 |
F
|
Q
|
H
|
L
|
P
|
E
|
L
|
R
|
T
|
L
|
310 |
T
|
L
|
N
|
G
|
A
|
S
|
Q
|
I
|
T
|
E
|
320 |
F
|
P
|
D
|
L
|
T
|
G
|
T
|
A
|
N
|
L
|
330 |
E
|
S
|
L
|
T
|
L
|
T
|
G
|
A
|
Q
|
I
|
340 |
S
|
S
|
L
|
P
|
Q
|
T
|
V
|
C
|
N
|
Q
|
350 |
L
|
P
|
N
|
L
|
Q
|
V
|
L
|
D
|
L
|
S
|
360 |
Y
|
N
|
L
|
L
|
E
|
D
|
L
|
P
|
S
|
F
|
370 |
S
|
V
|
C
|
Q
|
K
|
L
|
Q
|
K
|
I
|
D
|
380 |
L
|
R
|
H
|
N
|
E
|
I
|
Y
|
E
|
I
|
K
|
390 |
V
|
D
|
T
|
F
|
Q
|
Q
|
L
|
L
|
S
|
L
|
400 |
R
|
S
|
L
|
N
|
L
|
A
|
W
|
N
|
K
|
I
|
410 |
A
|
I
|
I
|
H
|
P
|
N
|
A
|
F
|
S
|
T
|
420 |
L
|
P
|
S
|
L
|
I
|
K
|
L
|
D
|
L
|
S
|
430 |
S
|
N
|
L
|
L
|
S
|
S
|
F
|
P
|
I
|
T
|
440 |
G
|
L
|
H
|
G
|
L
|
T
|
H
|
L
|
K
|
L
|
450 |
T
|
G
|
N
|
H
|
A
|
L
|
Q
|
S
|
L
|
I
|
460 |
S
|
S
|
E
|
N
|
F
|
P
|
E
|
L
|
K
|
V
|
470 |
I
|
E
|
M
|
P
|
Y
|
A
|
Y
|
Q
|
C
|
C
|
480 |
A
|
F
|
G
|
V
|
C
|
E
|
N
|
A
|
Y
|
K
|
490 |
I
|
S
|
N
|
Q
|
W
|
N
|
K
|
G
|
D
|
N
|
500 |
S
|
S
|
M
|
D
|
D
|
L
|
H
|
K
|
K
|
D
|
510 |
A
|
G
|
M
|
F
|
Q
|
A
|
Q
|
D
|
E
|
R
|
520 |
D
|
L
|
E
|
D
|
F
|
L
|
L
|
D
|
F
|
E
|
530 |
E
|
D
|
L
|
K
|
A
|
L
|
H
|
S
|
V
|
Q
|
540 |
C
|
S
|
P
|
S
|
P
|
G
|
P
|
F
|
K
|
P
|
550 |
TM1 | |||||||||
C
|
E
|
H
|
L
|
L
|
D
|
G
|
W
|
L
|
I
|
560 |
R
|
I
|
G
|
V
|
W
|
T
|
I
|
A
|
V
|
L
|
570 |
A
|
L
|
T
|
C
|
N
|
A
|
L
|
V
|
T
|
S
|
580 |
ICL1 | |||||||||
T
|
V
|
F
|
R
|
S
|
P
|
L
|
Y
|
I
|
S
|
590 |
TM2 | |||||||||
P
|
I
|
K
|
L
|
L
|
I
|
G
|
V
|
I
|
A
|
600 |
A
|
V
|
N
|
M
|
L
|
T
|
G
|
V
|
S
|
S
|
610 |
A
|
V
|
L
|
A
|
G
|
V
|
D
|
A
|
F
|
T
|
620 |
ECL1 | |||||||||
F
|
G
|
S
|
F
|
A
|
R
|
H
|
G
|
A
|
W
|
630 |
TM3 | |||||||||
W
|
E
|
N
|
G
|
V
|
G
|
C
|
H
|
V
|
I
|
640 |
G
|
F
|
L
|
S
|
I
|
F
|
A
|
S
|
E
|
S
|
650 |
S
|
V
|
F
|
L
|
L
|
T
|
L
|
A
|
A
|
L
|
660 |
E
|
R
|
G
|
F
|
S
|
V
|
K
|
Y
|
S
|
A
|
670 |
ICL2 | TM4 | ||||||||
K
|
F
|
E
|
T
|
K
|
A
|
P
|
F
|
S
|
S
|
680 |
L
|
K
|
V
|
I
|
I
|
L
|
L
|
C
|
A
|
L
|
690 |
L
|
A
|
L
|
T
|
M
|
A
|
A
|
V
|
P
|
L
|
700 |
ECL2 | |||||||||
L
|
G
|
G
|
S
|
K
|
Y
|
G
|
A
|
S
|
P
|
710 |
L
|
C
|
L
|
P
|
L
|
P
|
F
|
G
|
E
|
P
|
720 |
TM5 | |||||||||
S
|
T
|
M
|
G
|
Y
|
M
|
V
|
A
|
L
|
I
|
730 |
L
|
L
|
N
|
S
|
L
|
C
|
F
|
L
|
M
|
M
|
740 |
T
|
I
|
A
|
Y
|
T
|
K
|
L
|
Y
|
C
|
N
|
750 |
ICL3 | |||||||||
L
|
D
|
K
|
G
|
D
|
L
|
E
|
N
|
I
|
W
|
760 |
TM6 | |||||||||
D
|
C
|
S
|
M
|
V
|
K
|
H
|
I
|
A
|
L
|
770 |
L
|
L
|
F
|
T
|
N
|
C
|
I
|
L
|
N
|
C
|
780 |
P
|
V
|
A
|
F
|
L
|
S
|
F
|
S
|
S
|
L
|
790 |
ECL3 | TM7 | ||||||||
I
|
N
|
L
|
T
|
F
|
I
|
S
|
P
|
E
|
V
|
800 |
I
|
K
|
F
|
I
|
L
|
L
|
V
|
V
|
V
|
P
|
810 |
L
|
P
|
A
|
C
|
L
|
N
|
P
|
L
|
L
|
Y
|
820 |
H8 | |||||||||
I
|
L
|
F
|
N
|
P
|
H
|
F
|
K
|
E
|
D
|
830 |
L
|
V
|
S
|
L
|
R
|
K
|
Q
|
T
|
Y
|
V
|
840 |
C-term | |||||||||
W
|
T
|
R
|
S
|
K
|
H
|
P
|
S
|
L
|
M
|
850 |
S
|
I
|
N
|
S
|
D
|
D
|
V
|
E
|
K
|
Q
|
860 |
S
|
C
|
D
|
S
|
T
|
Q
|
A
|
L
|
V
|
T
|
870 |
F
|
T
|
S
|
S
|
S
|
I
|
T
|
Y
|
D
|
L
|
880 |
P
|
P
|
S
|
S
|
V
|
P
|
S
|
P
|
A
|
Y
|
890 |
P
|
V
|
T
|
E
|
S
|
C
|
H
|
L
|
S
|
S
|
900 |
V
|
A
|
F
|
V
|
P
|
C
|
L
|
LINKS
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
R-spondin-2, R-spondin-3, R-spondin-1, R-spondin-4
STRUCTURE MODELS
STRUCTURES
No structures available