LGR5 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

LGR5

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

NGL is a WebGL based 3D viewer powered by MMTF.

MAIN TEMPLATE

LH receptor (sequence similarity: 23%) PDB: 7FIJ
Align

TEMPLATES

7FIG (LH receptor)
7FIJ (LH receptor)
7F4H (MC1 receptor)
7T10 (SST2 receptor)
5W0P (Rhodopsin)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 84.0 9.1 7.0
Side-chains 5.9 69.3 24.7

Number of backbone templates: 5
Number of rotamer templates: 55

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
TM1 557 G 1.32x32 LH receptor 7FIG - -
TM1 558 W 1.33x33 LH receptor 7FIG 5-HT2C receptor 6BQG
TM1 559 L 1.34x34 LH receptor 7FIG S1P3 receptor 7EW4
TM1 560 I 1.35x35 LH receptor 7FIG AT2 receptor 5UNG
TM1 561 R 1.36x36 LH receptor 7FIG LH receptor 7FIG
TM1 562 I 1.37x37 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM1 563 G 1.38x38 LH receptor 7FIJ OX2 receptor 7L1V
TM1 564 V 1.39x39 LH receptor 7FIJ - -
TM1 565 W 1.40x40 LH receptor 7FIJ LH receptor 7FIJ
TM1 566 T 1.41x41 LH receptor 7FIJ MC4 receptor 6W25
TM1 567 I 1.42x42 LH receptor 7FIJ LH receptor 7FIG
TM1 568 A 1.43x43 LH receptor 7FIJ A2A receptor 4UHR
TM1 569 V 1.44x44 LH receptor 7FIJ MT1 receptor 7VGZ
TM1 570 L 1.45x45 LH receptor 7FIJ LH receptor 7FIG
TM1 571 A 1.46x46 LH receptor 7FIJ LH receptor 7FIJ
TM1 572 L 1.47x47 LH receptor 7FIJ SST2 receptor 7T10
TM1 573 T 1.48x48 LH receptor 7FIJ 5-HT1F receptor 7EXD
TM1 574 C 1.49x49 LH receptor 7FIJ - -
TM1 575 N 1.50x50 LH receptor 7FIJ LH receptor 7FIG
TM1 576 A 1.51x51 LH receptor 7FIJ MC1 receptor 7F4H
TM1 577 L 1.52x52 LH receptor 7FIJ SST2 receptor 7T10
TM1 578 V 1.53x53 LH receptor 7FIJ LH receptor 7FIG
TM1 579 T 1.54x54 LH receptor 7FIJ - -
TM1 580 S 1.55x55 LH receptor 7FIJ B2 receptor 7F2O
TM1 581 T 1.56x56 LH receptor 7FIJ MC1 receptor 7F4H
TM1 582 V 1.57x57 LH receptor 7FIJ MT1 receptor 7VGZ
TM1 583 F 1.58x58 LH receptor 7FIJ α2A-adrenoceptor 7EJ8
TM1 584 R 1.59x59 LH receptor 7FIJ MT1 receptor 7VGZ
TM1 585 S 1.60x60 LH receptor 7FIJ LH receptor 7FIG
ICL1 586 P - LH receptor 7FIJ - -
ICL1 587 L - LH receptor 7FIJ - -
ICL1 588 Y - LH receptor 7FIJ - -
ICL1 589 I - LH receptor 7FIJ - -
TM2 590 S 2.37x37 LH receptor 7FIJ MC1 receptor 7F4H
TM2 591 P 2.38x38 LH receptor 7FIJ Rhodopsin 5W0P
TM2 592 I 2.39x39 LH receptor 7FIJ P2Y1 receptor 4XNW
TM2 593 K 2.40x40 LH receptor 7FIJ PAF receptor 5ZKQ
TM2 594 L 2.41x41 LH receptor 7FIJ β1-adrenoceptor 7BU7
TM2 595 L 2.42x42 LH receptor 7FIJ LH receptor 7FIG
TM2 596 I 2.43x43 LH receptor 7FIJ SST2 receptor 7T10
TM2 597 G 2.44x44 LH receptor 7FIJ 5-HT1D receptor 7E32
TM2 598 V 2.45x45 LH receptor 7FIJ - -
TM2 599 I 2.46x46 LH receptor 7FIJ - -
TM2 600 A 2.47x47 LH receptor 7FIJ SST2 receptor 7T10
TM2 601 A 2.48x48 LH receptor 7FIJ A2A receptor 4UHR
TM2 602 V 2.49x49 LH receptor 7FIJ - -
TM2 603 N 2.50x50 LH receptor 7FIJ A2A receptor 5WF5
TM2 604 M 2.51x51 LH receptor 7FIJ MC4 receptor 6W25
TM2 605 L 2.52x52 LH receptor 7FIJ SST2 receptor 7T10
TM2 606 T 2.53x53 LH receptor 7FIJ NTS1 receptor 6OSA
TM2 607 G 2.54x54 LH receptor 7FIJ LH receptor 7FIJ
TM2 608 V 2.55x55 LH receptor 7FIJ A2A receptor 4UHR
TM2 609 S 2.56x56 LH receptor 7FIJ MC1 receptor 7F4H
TM2 610 S 2.57x57 LH receptor 7FIJ EP2 receptor 7CX2
TM2 611 A 2.58x58 LH receptor 7FIJ CB2 receptor 6PT0
TM2 612 V 2.59x59 LH receptor 7FIJ S1P3 receptor 7EW4
TM2 613 L 2.60x60 LH receptor 7FIJ SST2 receptor 7T10
TM2 614 A 2.61x61 LH receptor 7FIJ LH receptor 7FIJ
TM2 615 G 2.62x62 LH receptor 7FIJ GPBA receptor 7CFN
TM2 616 V 2.63x63 LH receptor 7FIJ LH receptor 7FIG
TM2 617 D 2.64x64 LH receptor 7FIJ LH receptor 7FIG
TM2 618 A 2.65x65 LH receptor 7FIJ CCR5 7O7F
TM2 619 F 2.66x66 LH receptor 7FIG 5-HT2B receptor 4NC3
TM2 620 T 2.67x67 LH receptor 7FIG LH receptor 7FIG
ECL1 621 F - - - - -
ECL1 622 G - - - - -
ECL1 623 S - - - - -
ECL1 624 F - - - - -
ECL1 625 A - - - - -
ECL1 626 R - - - - -
ECL1 627 H - - - - -
ECL1 628 G - - - - -
ECL1 629 A - - - - -
TM3 630 W 3.18x18 MC1 receptor 7F4H - -
TM3 631 W 3.19x19 MC1 receptor 7F4H - -
TM3 632 E 3.20x20 MC1 receptor 7F4H - -
TM3 633 N 3.21x21 MC1 receptor 7F4H - -
TM3 634 G 3.22x22 MC1 receptor 7F4H D1 receptor 7JVQ
TM3 635 V 3.23x23 LH receptor 7FIJ AT2 receptor 5UNG
TM3 636 G 3.24x24 LH receptor 7FIJ LH receptor 7FIJ
TM3 637 C 3.25x25 LH receptor 7FIJ LH receptor 7FIJ
TM3 638 H 3.26x26 LH receptor 7FIJ - -
TM3 639 V 3.27x27 LH receptor 7FIJ MT1 receptor 7VGZ
TM3 640 I 3.28x28 LH receptor 7FIJ A2A receptor 4UHR
TM3 641 G 3.29x29 LH receptor 7FIJ LH receptor 7FIJ
TM3 642 F 3.30x30 LH receptor 7FIJ LH receptor 7FIG
TM3 643 L 3.31x31 LH receptor 7FIJ MT1 receptor 7VGZ
TM3 644 S 3.32x32 LH receptor 7FIJ ghrelin receptor 7NA7
TM3 645 I 3.33x33 LH receptor 7FIJ 5-HT1D receptor 7E32
TM3 646 F 3.34x34 LH receptor 7FIJ LH receptor 7FIG
TM3 647 A 3.35x35 LH receptor 7FIJ LH receptor 7FIJ
TM3 648 S 3.36x36 LH receptor 7FIJ LH receptor 7FIG
TM3 649 E 3.37x37 LH receptor 7FIJ LH receptor 7FIG
TM3 650 S 3.38x38 LH receptor 7FIJ A2A receptor 4UHR
TM3 651 S 3.39x39 LH receptor 7FIJ LH receptor 7FIG
TM3 652 V 3.40x40 LH receptor 7FIJ LH receptor 7FIG
TM3 653 F 3.41x41 LH receptor 7FIJ SST2 receptor 7T10
TM3 654 L 3.42x42 LH receptor 7FIJ AT1 receptor 6DO1
TM3 655 L 3.43x43 LH receptor 7FIJ LH receptor 7FIG
TM3 656 T 3.44x44 LH receptor 7FIJ LH receptor 7FIG
TM3 657 L 3.45x45 LH receptor 7FIJ OT receptor 7RYC
TM3 658 A 3.46x46 LH receptor 7FIJ CB1 receptor 7V3Z
TM3 659 A 3.47x47 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM3 660 L 3.48x48 LH receptor 7FIJ LH receptor 7FIG
TM3 661 E 3.49x49 LH receptor 7FIJ LH receptor 7FIG
TM3 662 R 3.50x50 LH receptor 7FIJ LH receptor 7FIG
TM3 663 G 3.51x51 LH receptor 7FIJ - -
TM3 664 F 3.52x52 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM3 665 S 3.53x53 LH receptor 7FIJ MC1 receptor 7F4H
TM3 666 V 3.54x54 LH receptor 7FIJ SST2 receptor 7T10
TM3 667 K 3.55x55 LH receptor 7FIJ A1 receptor 6D9H
TM3 668 Y 3.56x56 LH receptor 7FIJ LH receptor 7FIG
ICL2 669 S 34.50x50 - - - -
ICL2 670 A 34.51x51 SST2 receptor 7T10 GPR88 7EJX
ICL2 671 K 34.52x52 SST2 receptor 7T10 β2-adrenoceptor 3SN6
ICL2 672 F 34.53x53 SST2 receptor 7T10 - -
ICL2 673 E 34.54x54 SST2 receptor 7T10 D1 receptor 7JVQ
ICL2 674 T 34.55x55 SST2 receptor 7T10 CXCR2 6LFO
ICL2 675 K 34.56x56 SST2 receptor 7T10 α2A-adrenoceptor 7EJ8
ICL2 676 A 34.57x57 - - - -
TM4 677 P 4.38x38 LH receptor 7FIJ US28 5WB1
TM4 678 F 4.39x39 LH receptor 7FIJ - -
TM4 679 S 4.40x40 LH receptor 7FIJ CCK1 receptor 7EZM
TM4 680 S 4.41x41 LH receptor 7FIJ CysLT2 receptor 6RZ6
TM4 681 L 4.42x42 LH receptor 7FIJ S1P1 receptor 7EO4
TM4 682 K 4.43x43 LH receptor 7FIJ SST2 receptor 7T10
TM4 683 V 4.44x44 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM4 684 I 4.45x45 LH receptor 7FIJ LH receptor 7FIG
TM4 685 I 4.46x46 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM4 686 L 4.47x47 LH receptor 7FIJ LH receptor 7FIG
TM4 687 L 4.48x48 LH receptor 7FIJ MT1 receptor 7VGZ
TM4 688 C 4.49x49 LH receptor 7FIJ A2A receptor 4UHR
TM4 689 A 4.50x50 LH receptor 7FIJ - -
TM4 690 L 4.51x51 LH receptor 7FIJ LH receptor 7FIG
TM4 691 L 4.52x52 LH receptor 7FIJ MT1 receptor 7VGZ
TM4 692 A 4.53x53 LH receptor 7FIJ Rhodopsin 5W0P
TM4 693 L 4.54x54 LH receptor 7FIJ SST2 receptor 7T10
TM4 694 T 4.55x55 LH receptor 7FIJ D2 receptor 7JVR
TM4 695 M 4.56x56 LH receptor 7FIJ GAL1 receptor 7WQ3
TM4 696 A 4.57x57 LH receptor 7FIJ LH receptor 7FIJ
TM4 697 A 4.58x58 LH receptor 7FIJ Rhodopsin 5W0P
TM4 698 V 4.59x59 LH receptor 7FIJ 5-HT2C receptor 6BQG
TM4 699 P 4.60x60 LH receptor 7FIJ LH receptor 7FIJ
TM4 700 L 4.61x61 LH receptor 7FIJ LH receptor 7FIG
TM4 701 L 4.62x62 LH receptor 7FIJ MT1 receptor 7VGZ
TM4 702 G 4.63x63 LH receptor 7FIG LH receptor 7FIG
ECL2 703 G - LH receptor 7FIJ - -
ECL2 704 S - LH receptor 7FIJ - -
ECL2 705 K - LH receptor 7FIJ - -
ECL2 706 Y - LH receptor 7FIJ - -
ECL2 707 G - LH receptor 7FIJ - -
ECL2 708 A - LH receptor 7FIJ - -
ECL2 709 S - LH receptor 7FIJ - -
ECL2 710 P - LH receptor 7FIJ - -
ECL2 711 L - LH receptor 7FIJ - -
ECL2 712 C 45.50x50 LH receptor 7FIJ LH receptor 7FIJ
ECL2 713 L 45.51x51 LH receptor 7FIJ A2A receptor 4UHR
ECL2 714 P 45.52x52 LH receptor 7FIJ LH receptor 7FIG
ECL2 715 L - LH receptor 7FIJ - -
ECL2 716 P - LH receptor 7FIJ - -
ECL2 717 F - LH receptor 7FIJ - -
ECL2 718 G - LH receptor 7FIJ - -
TM5 719 E 5.33x33 LH receptor 7FIJ - -
TM5 720 P 5.34x34 LH receptor 7FIJ GAL2 receptor 7WQ4
TM5 721 S 5.35x35 LH receptor 7FIJ P2Y1 receptor 4XNW
TM5 722 T 5.36x36 LH receptor 7FIJ - -
TM5 723 M 5.37x37 LH receptor 7FIJ A2A receptor 4UHR
TM5 724 G 5.38x38 LH receptor 7FIJ SST2 receptor 7T10
TM5 725 Y 5.39x39 LH receptor 7FIJ LH receptor 7FIG
TM5 726 M 5.40x40 LH receptor 7FIJ A2A receptor 4UHR
TM5 727 V 5.41x41 LH receptor 7FIJ A2A receptor 4UHR
TM5 728 A 5.42x42 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM5 729 L 5.43x43 LH receptor 7FIJ MC1 receptor 7F4H
TM5 730 I 5.44x44 LH receptor 7FIJ MC4 receptor 6W25
TM5 731 L 5.45x45 LH receptor 7FIJ 5-HT2B receptor 5TVN
TM5 732 L 5.46x46 LH receptor 7FIJ LH receptor 7FIG
TM5 733 N 5.47x47 LH receptor 7FIJ LH receptor 7FIG
TM5 734 S 5.48x48 LH receptor 7FIJ S1P2 receptor 7T6B
TM5 735 L 5.49x49 LH receptor 7FIJ S1P1 receptor 7TD4
TM5 736 C 5.50x50 LH receptor 7FIJ - -
TM5 737 F 5.51x51 LH receptor 7FIJ LH receptor 7FIG
TM5 738 L 5.52x52 LH receptor 7FIJ A2A receptor 4UHR
TM5 739 M 5.53x53 LH receptor 7FIJ - -
TM5 740 M 5.54x54 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM5 741 T 5.55x55 LH receptor 7FIJ ghrelin receptor 7NA7
TM5 742 I 5.56x56 LH receptor 7FIJ 5-HT1D receptor 7E32
TM5 743 A 5.57x57 LH receptor 7FIJ OX2 receptor 7L1V
TM5 744 Y 5.58x58 LH receptor 7FIJ LH receptor 7FIG
TM5 745 T 5.59x59 LH receptor 7FIJ AT1 receptor 6DO1
TM5 746 K 5.60x60 LH receptor 7FIJ LH receptor 7FIG
TM5 747 L 5.61x61 LH receptor 7FIJ Rhodopsin 5W0P
TM5 748 Y 5.62x62 LH receptor 7FIJ LH receptor 7FIG
TM5 749 C 5.63x63 LH receptor 7FIJ S1P2 receptor 7T6B
TM5 750 N 5.64x64 LH receptor 7FIJ - -
TM5 751 L 5.65x65 LH receptor 7FIJ D2 receptor 7JVR
TM5 752 D 5.66x66 SST2 receptor 7T10 - -
TM5 753 K 5.67x67 SST2 receptor 7T10 β1-adrenoceptor 7BU7
ICL3 754 G - - - - -
ICL3 755 D - - - - -
ICL3 756 L - - - - -
ICL3 757 E - - - - -
ICL3 758 N - - - - -
TM6 759 I 6.28x28 LH receptor 7FIJ AT2 receptor 5UNG
TM6 760 W 6.29x29 LH receptor 7FIJ - -
TM6 761 D 6.30x30 LH receptor 7FIJ LH receptor 7FIJ
TM6 762 C 6.31x31 LH receptor 7FIJ - -
TM6 763 S 6.32x32 LH receptor 7FIJ PAR1 3VW7
TM6 764 M 6.33x33 LH receptor 7FIJ EP4 receptor 7D7M
TM6 765 V 6.34x34 LH receptor 7FIJ ghrelin receptor 7NA7
TM6 766 K 6.35x35 LH receptor 7FIJ LH receptor 7FIG
TM6 767 H 6.36x36 LH receptor 7FIJ - -
TM6 768 I 6.37x37 LH receptor 7FIJ AT1 receptor 6DO1
TM6 769 A 6.38x38 LH receptor 7FIJ LH receptor 7FIJ
TM6 770 L 6.39x39 LH receptor 7FIJ A1 receptor 6D9H
TM6 771 L 6.40x40 LH receptor 7FIJ LH receptor 7FIG
TM6 772 L 6.41x41 LH receptor 7FIJ MC1 receptor 7F4H
TM6 773 F 6.42x42 LH receptor 7FIJ LH receptor 7FIG
TM6 774 T 6.43x43 LH receptor 7FIJ LH receptor 7FIG
TM6 775 N 6.44x44 LH receptor 7FIJ - -
TM6 776 C 6.45x45 LH receptor 7FIJ GAL2 receptor 7WQ4
TM6 777 I 6.46x46 LH receptor 7FIJ MT1 receptor 7VGZ
TM6 778 L 6.47x47 LH receptor 7FIJ succinate receptor 6RNK
TM6 779 N 6.48x48 LH receptor 7FIJ - -
TM6 780 C 6.49x49 LH receptor 7FIJ 5-HT2C receptor 6BQG
TM6 781 P 6.50x50 LH receptor 7FIJ LH receptor 7FIG
TM6 782 V 6.51x51 LH receptor 7FIJ CB2 receptor 6PT0
TM6 783 A 6.52x52 LH receptor 7FIJ Rhodopsin 5W0P
TM6 784 F 6.53x53 LH receptor 7FIJ LH receptor 7FIG
TM6 785 L 6.54x54 LH receptor 7FIJ AT2 receptor 5UNG
TM6 786 S 6.55x55 LH receptor 7FIJ 5-HT1D receptor 7E32
TM6 787 F 6.56x56 LH receptor 7FIJ Rhodopsin 5W0P
TM6 788 S 6.57x57 LH receptor 7FIJ LH receptor 7FIG
TM6 789 S 6.58x58 LH receptor 7FIJ SST2 receptor 7T10
TM6 790 L 6.59x59 LH receptor 7FIJ A1 receptor 6D9H
TM6 791 I 6.60x60 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM6 792 N 6.61x61 LH receptor 7FIJ NK1 receptor 7P00
ECL3 793 L - - - - -
ECL3 794 T - Rhodopsin 5W0P - -
ECL3 795 F - Rhodopsin 5W0P - -
ECL3 796 I - Rhodopsin 5W0P - -
ECL3 797 S - - - - -
TM7 798 P 7.31x30 LH receptor 7FIG - -
TM7 799 E 7.32x31 LH receptor 7FIG MT1 receptor 7VGZ
TM7 800 V 7.33x32 LH receptor 7FIJ D2 receptor 7JVR
TM7 801 I 7.34x33 LH receptor 7FIJ 5-HT1B receptor 6G79
TM7 802 K 7.35x34 LH receptor 7FIJ LH receptor 7FIG
TM7 803 F 7.36x35 LH receptor 7FIJ GPR52 6LI3
TM7 804 I 7.37x36 LH receptor 7FIJ Rhodopsin 5W0P
TM7 805 L 7.38x37 LH receptor 7FIJ LH receptor 7FIG
TM7 806 L 7.39x38 LH receptor 7FIJ MC1 receptor 7F4H
TM7 807 V 7.40x39 LH receptor 7FIJ SST2 receptor 7T10
TM7 808 V 7.41x40 LH receptor 7FIJ S1P2 receptor 7T6B
TM7 809 V 7.42x41 LH receptor 7FIJ OX2 receptor 7L1V
TM7 810 P 7.43x42 LH receptor 7FIJ LH receptor 7FIJ
TM7 811 L 7.44x43 LH receptor 7FIJ 5-HT1D receptor 7E32
TM7 812 P 7.45x45 LH receptor 7FIJ - -
TM7 813 A 7.46x46 LH receptor 7FIJ Rhodopsin 5W0P
TM7 814 C 7.47x47 LH receptor 7FIJ LH receptor 7FIG
TM7 815 L 7.48x48 LH receptor 7FIJ MT1 receptor 7VGZ
TM7 816 N 7.49x49 LH receptor 7FIJ LH receptor 7FIG
TM7 817 P 7.50x50 LH receptor 7FIJ LH receptor 7FIG
TM7 818 L 7.51x51 LH receptor 7FIJ β2-adrenoceptor 3SN6
TM7 819 L 7.52x52 LH receptor 7FIJ LH receptor 7FIG
TM7 820 Y 7.53x53 LH receptor 7FIJ LH receptor 7FIG
TM7 821 I 7.54x54 LH receptor 7FIJ Rhodopsin 5W0P
TM7 822 L 7.55x55 LH receptor 7FIJ MT1 receptor 7VGZ
TM7 823 F 7.56x56 LH receptor 7FIJ LH receptor 7FIG
H8 824 N 8.47x47 LH receptor 7FIJ MT1 receptor 7VGZ
H8 825 P 8.48x48 LH receptor 7FIJ β2-adrenoceptor 3SN6
H8 826 H 8.49x49 LH receptor 7FIJ succinate receptor 6RNK
H8 827 F 8.50x50 LH receptor 7FIJ LH receptor 7FIG
H8 828 K 8.51x51 LH receptor 7FIJ AT1 receptor 6DO1
H8 829 E 8.52x52 LH receptor 7FIJ FPR2/ALX 7WVX
H8 830 D 8.53x53 LH receptor 7FIJ LH receptor 7FIG
H8 831 L 8.54x54 LH receptor 7FIJ MC1 receptor 7F4H
H8 832 V 8.55x55 LH receptor 7FIJ Rhodopsin 4X1H
H8 833 S 8.56x56 LH receptor 7FIJ AT2 receptor 5UNG
H8 834 L 8.57x57 LH receptor 7FIJ LH receptor 7FIG
H8 835 R 8.58x58 LH receptor 7FIJ - -
H8 836 K 8.59x59 LH receptor 7FIJ CCR6 6WWZ
H8 837 Q 8.60x60 LH receptor 7FIJ succinate receptor 6IBB
H8 838 T 8.61x61 LH receptor 7FIJ - -
C-term 839 Y - LH receptor 7FIJ LH receptor 7FIJ
C-term 840 V - LH receptor 7FIJ LH receptor 7FIJ
C-term 841 W - LH receptor 7FIJ LH receptor 7FIJ
C-term 842 T - - - - -
C-term 843 R - - - - -