TAS2R40 (t2r40_human)

FAMILY

Class T2 (Taste 2) Sensory receptors Taste 2 receptors TAS2R40

GENE

TAS2R40 (GPR60)

ORGANISM

Human (Homo sapiens)

ALT. NAMES

Taste receptor type 2 member 40, T2R40, G-protein coupled receptor 60, Taste receptor type 2 member 58, T2R58

SOURCE

SWISSPROT

SEQUENCE

N-term        
M
A
T
V
N
T
D
A
T
D
10
      TM1        
K
D
I
S
K
F
K
V
T
F
20
                   
T
L
V
V
S
G
I
E
C
I
30
                   
T
G
I
L
G
S
G
F
I
T
40
                   
A
I
Y
G
A
E
W
A
R
G
50
  ICL1 TM2    
K
T
L
P
T
G
D
R
I
M
60
                   
L
M
L
S
F
S
R
L
L
L
70
                   
Q
I
W
M
M
L
E
N
I
F
80
        ECL1 TM3
S
L
L
F
R
I
V
Y
N
Q
90
                 
N
S
V
Y
I
L
F
K
V
I
100
                   
T
V
F
L
N
H
S
N
L
W
110
                   
F
A
A
W
L
K
V
F
Y
C
120
        ICL2    
L
R
I
A
N
F
N
H
P
L
130
            TM4  
F
F
L
M
K
R
K
I
I
V
140
                   
L
M
P
W
L
L
R
L
S
V
150
                   
L
V
S
L
S
F
S
F
P
L
160
          ECL2  
S
R
D
V
F
N
V
Y
V
N
170
                   
S
S
I
P
I
P
S
S
N
S
180
                   
T
E
K
K
Y
F
S
E
T
N
190
      TM5        
M
V
N
L
V
F
F
Y
N
M
200
                   
G
I
F
V
P
L
I
M
F
I
210
                   
L
A
A
T
L
L
I
L
S
L
220
                   
K
R
H
T
L
H
M
G
S
N
230
  ICL3 TM6    
A
T
G
S
R
D
P
S
M
K
240
                   
A
H
I
G
A
I
K
A
T
S
250
                   
Y
F
L
I
L
Y
I
F
N
A
260
                   
I
A
L
F
L
S
T
S
N
I
270
    ECL3 TM7  
F
D
T
Y
S
S
W
N
I
L
280
                   
C
K
I
I
M
A
A
Y
P
A
290
                   
G
H
S
V
Q
L
I
L
G
N
300
H8                
P
G
L
R
R
A
W
K
R
F
310
                   
Q
H
Q
V
P
L
Y
L
K
G
320
C-term
Q
T
L

LINKS

BitterDB

Guide To Pharmacology

UniProt

DIAGRAMS

7TM

ICL1 T L ICL1ECL1 R I ECL1ICL2 N F N H P L F F L M K R ICL2ECL2 N V Y V N S S I P I P S S N S T E K K Y F S E T N M V N ECL2ICL3 T G S R ICL3ECL3 T Y ECL3N-term M A T V N T D A T D K D I N-termC-term K G Q T L C-term S K F K V T F T L V V S G I E C I T G I L G S G F I T A I Y G A E W A R G K P T G D R I M L M L S F S R L L L Q I W M M L E N I F S L L F V Y N Q N S V Y I L F K V I T V F L N H S N L W F A A W L K V F Y C L R I A K I I V L M P W L L R L S V L V S L S F S F P L S R D V F L V F F Y N M G I F V P L I M F I L A A T L L I L S L K R H T L H M G S N A D P S M K A H I G A I K A T S Y F L I L Y I F N A I A L F L S T S N I F D S S W N I L C K I I M A A Y P A G H S V Q L I L G N P G W K R V P L L R R A F Q H Q Y L
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

G S G L I G T I C E I G S V V L T F T V 1 L M L S F S R L L L Q I W M M L E N I F 2 W A A F W L N S H N L F V T I V K F L I 3 M P W L L R L S V L V S L S F S F P L S 4 A A L I F M I L P V F I G M N Y F F V L 5 T S Y F L I L Y I F N A I A L F L S T S 6 V S H G A P Y A A M I I K C L I N W S 7
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Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

MUTATIONS

0 mutation data points available.

PHYSIOLOGICAL LIGANDS

No physiological ligands available

STRUCTURE MODELS

t2r40_human active,

t2r40_human inactive

STRUCTURES

No structures available