TAS2R40 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2021-02-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CXCR4 (sequence similarity: 31%) PDB: 3ODU

TEMPLATES

3ODU (CXCR4)
6M9T (EP3 receptor)
6BQH (5-HT2C receptor)
6LI1 (GPR52)
4PXZ (P2Y12 receptor)
5ZKC (M2 receptor)
5ZBH (Y1 receptor)
6KO5 (ghrelin receptor)
6VMS (D2 receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 69.3 16.7 14.1
Side-chains 13.4 52.3 34.3

Number of backbone templates: 9
Number of rotamer templates: 54

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 13 I CXCR4 3ODU CXCR4 3ODU
N-term 14 S CXCR4 3ODU CXCR4 3ODU
N-term 15 K CXCR4 3ODU CXCR4 3ODU
N-term 16 F CXCR4 3ODU CXCR4 3ODU
N-term 17 K CXCR4 3ODU CXCR4 3ODU
TM1 18 V 1.32x32 CXCR4 3ODU M2 receptor 5ZKC
TM1 19 T 1.33x33 CXCR4 3ODU CB2 receptor 5ZTY
TM1 20 F 1.34x34 CXCR4 3ODU CXCR4 3ODU
TM1 21 T 1.35x35 CXCR4 3ODU S1P1 receptor 3V2Y
TM1 22 L 1.36x36 CXCR4 3ODU D4 receptor 5WIV
TM1 23 V 1.37x37 CXCR4 3ODU D4 receptor 5WIV
TM1 24 V 1.38x38 CXCR4 3ODU M2 receptor 5ZKC
TM1 25 S 1.39x39 CXCR4 3ODU CB1 receptor 5TGZ
TM1 26 G 1.40x40 CXCR4 3ODU M2 receptor 5ZKC
TM1 27 I 1.41x41 CXCR4 3ODU CXCR4 3ODU
TM1 28 E 1.42x42 CXCR4 3ODU succinate receptor 6RNK
TM1 29 C 1.43x43 CXCR4 3ODU H1 receptor 3RZE
TM1 30 I 1.44x44 CXCR4 3ODU 5-HT2C receptor 6BQH
TM1 31 T 1.45x45 CXCR4 3ODU CXCR4 3ODU
TM1 32 G 1.46x46 CXCR4 3ODU CXCR4 3ODU
TM1 33 I 1.47x47 CXCR4 3ODU CXCR4 3ODU
TM1 34 L 1.48x48 CXCR4 3ODU 5-HT1B receptor 4IAQ
TM1 35 G 1.49x49 CXCR4 3ODU CXCR4 3ODU
TM1 36 S 1.50x50 CXCR4 3ODU - -
TM1 37 G 1.51x51 CXCR4 3ODU CXCR4 3ODU
TM1 38 F 1.52x52 CXCR4 3ODU 5-HT1B receptor 4IAQ
TM1 39 I 1.53x53 CXCR4 3ODU DP2 receptor 6D27
TM1 40 T 1.54x54 CXCR4 3ODU - -
TM1 41 A 1.55x55 CXCR4 3ODU 5-HT1B receptor 4IAQ
TM1 42 I 1.56x56 CXCR4 3ODU Y1 receptor 5ZBH
TM1 43 Y 1.57x57 CXCR4 3ODU CCR9 5LWE
TM1 44 G 1.58x58 CXCR4 3ODU CXCR4 3ODU
TM1 45 A 1.59x59 CXCR4 3ODU NK1 receptor 6HLP
TM1 46 E 1.60x60 CXCR4 3ODU C5a1 receptor 5O9H
TM1 47 W 1.61x61 EP3 receptor 6M9T - -
TM1 48 A 1.62x62 EP3 receptor 6M9T - -
ICL1 49 R 12.48x48 - - - -
ICL1 50 G 12.49x49 5-HT2C receptor 6BQH - -
ICL1 51 K 12.50x50 5-HT2C receptor 6BQH - -
ICL1 52 T 12.51x51 - - - -
TM2 53 L 2.36x36 GPR52 6LI1 - -
TM2 54 P 2.37x37 CXCR4 3ODU GPBA receptor 7CFN
TM2 55 T 2.38x38 CXCR4 3ODU D2 receptor 6CM4
TM2 56 G 2.39x39 CXCR4 3ODU H1 receptor 3RZE
TM2 57 D 2.40x40 CXCR4 3ODU CXCR4 3ODU
TM2 58 R 2.41x41 CXCR4 3ODU - -
TM2 59 I 2.42x42 CXCR4 3ODU Rhodopsin 4ZWJ
TM2 60 M 2.43x43 CXCR4 3ODU LPA1 receptor 4Z35
TM2 61 L 2.44x44 CXCR4 3ODU CXCR4 3ODU
TM2 62 M 2.45x45 CXCR4 3ODU - -
TM2 63 L 2.46x46 CXCR4 3ODU CXCR4 3ODU
TM2 64 S 2.47x47 CXCR4 3ODU CXCR4 3ODU
TM2 65 F 2.48x48 CXCR4 3ODU Y1 receptor 5ZBH
TM2 66 S 2.49x49 CXCR4 3ODU Y1 receptor 5ZBH
TM2 67 R 2.50x50 CXCR4 3ODU - -
TM2 68 L 2.51x51 CXCR4 3ODU CXCR4 3ODU
TM2 69 L 2.52x52 CXCR4 3ODU CXCR4 3ODU
TM2 70 L 2.53x53 CXCR4 3ODU 5-HT2A receptor 6A94
TM2 71 Q 2.54x54 CXCR4 3ODU EP3 receptor 6M9T
TM2 72 I 2.55x55 CXCR4 3ODU CXCR4 3ODU
TM2 73 W 2.56x56 CXCR4 3ODU PAR2 5NDD
TM2 74 M 2.57x57 CXCR4 3ODU 5-HT2C receptor 6BQH
TM2 75 M 2.58x58 CXCR4 3ODU Rhodopsin 6I9K
TM2 76 L 2.59x59 CXCR4 3ODU 5-HT2C receptor 6BQH
TM2 77 E 2.60x60 CXCR4 3ODU NTS1 receptor 4BUO
TM2 78 N 2.61x61 CXCR4 3ODU NK1 receptor 6HLP
TM2 79 I 2.62x62 CXCR4 3ODU CB1 receptor 5TGZ
TM2 80 F 2.63x63 CXCR4 3ODU BLT1 receptor 5X33
TM2 81 S 2.64x64 CXCR4 3ODU A2A receptor 3VG9
TM2 82 L 2.65x65 CXCR4 3ODU 5-HT2C receptor 6BQH
TM2 83 L 2.66x66 CXCR4 3ODU NOP receptor 5DHG
ECL1 84 F - - - -
ECL1 85 R P2Y12 receptor 4PXZ - -
ECL1 86 I - - - -
TM3 87 V 3.18x18 P2Y12 receptor 4PXZ - -
TM3 88 Y 3.19x19 P2Y12 receptor 4PXZ - -
TM3 89 N 3.20x20 P2Y12 receptor 4PXZ - -
TM3 90 Q 3.21x21 CXCR4 3ODU - -
TM3 91 N 3.22x22 CXCR4 3ODU CXCR4 3ODU
TM3 92 S 3.23x23 CXCR4 3ODU LPA1 receptor 4Z35
TM3 93 V 3.24x24 CXCR4 3ODU M2 receptor 5ZKC
TM3 94 Y 3.25x25 CXCR4 3ODU - -
TM3 95 I 3.26x26 CXCR4 3ODU succinate receptor 6RNK
TM3 96 L 3.27x27 CXCR4 3ODU M2 receptor 5ZKC
TM3 97 F 3.28x28 CXCR4 3ODU D2 receptor 6CM4
TM3 98 K 3.29x29 CXCR4 3ODU OT receptor 6TPK
TM3 99 V 3.30x30 CXCR4 3ODU CXCR4 3ODU
TM3 100 I 3.31x31 CXCR4 3ODU CXCR4 3ODU
TM3 101 T 3.32x32 CXCR4 3ODU - -
TM3 102 V 3.33x33 CXCR4 3ODU 5-HT2C receptor 6BQH
TM3 103 F 3.34x34 CXCR4 3ODU AT1 receptor 4ZUD
TM3 104 L 3.35x35 CXCR4 3ODU D4 receptor 5WIV
TM3 105 N 3.36x36 CXCR4 3ODU - -
TM3 106 H 3.37x37 CXCR4 3ODU - -
TM3 107 S 3.38x38 CXCR4 3ODU CXCR4 3ODU
TM3 108 N 3.39x39 CXCR4 3ODU - -
TM3 109 L 3.40x40 CXCR4 3ODU EP4 receptor 5YWY
TM3 110 W 3.41x41 CXCR4 3ODU CXCR4 3ODU
TM3 111 F 3.42x42 CXCR4 3ODU CCR2 5T1A
TM3 112 A 3.43x43 CXCR4 3ODU EP3 receptor 6M9T
TM3 113 A 3.44x44 CXCR4 3ODU CXCR4 3ODU
TM3 114 W 3.45x45 CXCR4 3ODU - -
TM3 115 L 3.46x46 CXCR4 3ODU AT1 receptor 4ZUD
TM3 116 K 3.47x47 CXCR4 3ODU - -
TM3 117 V 3.48x48 CXCR4 3ODU Y1 receptor 5ZBH
TM3 118 F 3.49x49 CXCR4 3ODU CysLT1 receptor 6RZ4
TM3 119 Y 3.50x50 CXCR4 3ODU - -
TM3 120 C 3.51x51 CXCR4 3ODU OT receptor 6TPK
TM3 121 L 3.52x52 CXCR4 3ODU CXCR4 3ODU
TM3 122 R 3.53x53 CXCR4 3ODU A1 receptor 5UEN
TM3 123 I 3.54x54 CXCR4 3ODU CXCR4 3ODU
TM3 124 A 3.55x55 CXCR4 3ODU D2 receptor 6CM4
TM3 125 N 3.56x56 CXCR4 3ODU 5-HT2A receptor 6A94
ICL2 126 F - - - -
ICL2 127 N - - - -
ICL2 128 H 34.50x50 M2 receptor 5ZKC - -
ICL2 129 P 34.51x51 M2 receptor 5ZKC CB2 receptor 5ZTY
ICL2 130 L 34.52x52 M2 receptor 5ZKC BLT1 receptor 5X33
ICL2 131 F 34.53x53 M2 receptor 5ZKC - -
ICL2 132 F 34.54x54 M2 receptor 5ZKC CCR6 6WWZ
ICL2 133 L 34.55x55 M2 receptor 5ZKC α2A-adrenoceptor 6KUX
ICL2 134 M 34.56x56 M2 receptor 5ZKC - -
ICL2 135 K 34.57x57 - - - -
TM4 136 R 4.38x38 CXCR4 3ODU CCR9 5LWE
TM4 137 K 4.39x39 CXCR4 3ODU H1 receptor 3RZE
TM4 138 I 4.40x40 CXCR4 3ODU - -
TM4 139 I 4.41x41 CXCR4 3ODU CCR7 6QZH
TM4 140 V 4.42x42 CXCR4 3ODU D2 receptor 6CM4
TM4 141 L 4.43x43 CXCR4 3ODU D4 receptor 5WIV
TM4 142 M 4.44x44 CXCR4 3ODU 5-HT2C receptor 6BQH
TM4 143 P 4.45x45 CXCR4 3ODU - -
TM4 144 W 4.46x46 CXCR4 3ODU - -
TM4 145 L 4.47x47 CXCR4 3ODU H1 receptor 3RZE
TM4 146 L 4.48x48 CXCR4 3ODU M3 receptor 5ZHP
TM4 147 R 4.49x49 CXCR4 3ODU - -
TM4 148 L 4.50x50 CXCR4 3ODU - -
TM4 149 S 4.51x51 CXCR4 3ODU - -
TM4 150 V 4.52x52 CXCR4 3ODU ghrelin receptor 6KO5
TM4 151 L 4.53x53 CXCR4 3ODU - -
TM4 152 V 4.54x54 CXCR4 3ODU 5-HT2A receptor 6A94
TM4 153 S 4.55x55 CXCR4 3ODU κ receptor 6VI4
TM4 154 L 4.56x56 CXCR4 3ODU CXCR4 3ODU
TM4 155 S 4.57x57 M2 receptor 5ZKC 5-HT2C receptor 6BQH
TM4 156 F 4.58x58 M2 receptor 5ZKC β2-adrenoceptor 5JQH
TM4 157 S 4.59x59 M2 receptor 5ZKC κ receptor 6VI4
TM4 158 F 4.60x60 CXCR4 3ODU MC4 receptor 6W25
TM4 159 P 4.61x61 CXCR4 3ODU - -
TM4 160 L 4.62x62 CXCR4 3ODU M2 receptor 5ZKC
TM4 161 S 4.63x63 CXCR4 3ODU - -
TM4 162 R 4.64x64 CXCR4 3ODU - -
TM4 163 D 4.65x65 CXCR4 3ODU - -
TM4 164 V 4.66x66 5-HT2C receptor 6BQH - -
TM4 165 F 4.67x67 5-HT2C receptor 6BQH M3 receptor 5ZHP
ECL2 166 N - - - -
ECL2 167 V - - - -
ECL2 168 Y - - - -
ECL2 169 V - - - -
ECL2 170 N - - - -
ECL2 171 S - - - -
ECL2 172 S - - - -
ECL2 173 I - - - -
ECL2 174 P - - - -
ECL2 175 I - - - -
ECL2 176 P - - - -
ECL2 177 S - - - -
ECL2 178 S - - - -
ECL2 179 N - - - -
ECL2 180 S - - - -
ECL2 181 T - - - -
ECL2 182 E - - - -
ECL2 183 K - - - -
ECL2 184 K - - - -
ECL2 185 Y - - - -
ECL2 186 F - - - -
TM5 187 S 5.32x32 Y1 receptor 5ZBH Y1 receptor 5ZBH
TM5 188 E 5.33x33 CXCR4 3ODU - -
TM5 189 T 5.34x34 CXCR4 3ODU EP4 receptor 5YWY
TM5 190 N 5.35x35 CXCR4 3ODU Rhodopsin 6I9K
TM5 191 M 5.36x36 CXCR4 3ODU PAR2 5NDD
TM5 192 V 5.37x37 CXCR4 3ODU CXCR4 3ODU
TM5 193 N 5.38x38 CXCR4 3ODU 5-HT2C receptor 6BQH
TM5 194 L 5.39x39 CXCR4 3ODU AT1 receptor 4ZUD
TM5 195 V 5.40x40 CXCR4 3ODU 5-HT2C receptor 6BQH
TM5 196 F 5.41x41 CXCR4 3ODU CXCR4 3ODU
TM5 197 F 5.42x42 CXCR4 3ODU BLT1 receptor 5X33
TM5 198 Y 5.43x43 CXCR4 3ODU Rhodopsin 6I9K
TM5 199 N 5.44x44 CXCR4 3ODU AT1 receptor 4ZUD
TM5 200 M 5.45x45 CXCR4 3ODU CXCR4 3ODU
TM5 201 G 5.46x46 ghrelin receptor 6KO5 α2A-adrenoceptor 6KUX
TM5 202 I 5.47x47 ghrelin receptor 6KO5 CB2 receptor 5ZTY
TM5 203 F 5.48x48 CXCR4 3ODU 5-HT2C receptor 6BQH
TM5 204 V 5.49x49 CXCR4 3ODU D2 receptor 6CM4
TM5 205 P 5.50x50 CXCR4 3ODU CXCR4 3ODU
TM5 206 L 5.51x51 CXCR4 3ODU 5-HT2C receptor 6BQH
TM5 207 I 5.52x52 CXCR4 3ODU CXCR4 3ODU
TM5 208 M 5.53x53 CXCR4 3ODU - -
TM5 209 F 5.54x54 CXCR4 3ODU - -
TM5 210 I 5.55x55 CXCR4 3ODU κ receptor 6VI4
TM5 211 L 5.56x56 CXCR4 3ODU D2 receptor 6CM4
TM5 212 A 5.57x57 CXCR4 3ODU CB1 receptor 5TGZ
TM5 213 A 5.58x58 CXCR4 3ODU - -
TM5 214 T 5.59x59 CXCR4 3ODU κ receptor 6VI4
TM5 215 L 5.60x60 CXCR4 3ODU 5-HT2C receptor 6BQH
TM5 216 L 5.61x61 CXCR4 3ODU Rhodopsin 4ZWJ
TM5 217 I 5.62x62 CXCR4 3ODU CXCR4 3ODU
TM5 218 L 5.63x63 CXCR4 3ODU κ receptor 6VI4
TM5 219 S 5.64x64 CXCR4 3ODU 5-HT2A receptor 6A94
TM5 220 L 5.65x65 D2 receptor 6VMS D2 receptor 6VMS
TM5 221 K 5.66x66 D2 receptor 6VMS M2 receptor 5ZKC
TM5 222 R 5.67x67 D2 receptor 6VMS D2 receptor 6VMS
TM5 223 H 5.68x68 D2 receptor 6VMS Rhodopsin 6I9K
TM5 224 T 5.69x69 D2 receptor 6VMS α2A-adrenoceptor 6KUX
TM5 225 L 5.70x70 D2 receptor 6VMS δ receptor 6PT2
TM5 226 H 5.71x71 D2 receptor 6VMS - -
TM5 227 M 5.72x72 D2 receptor 6VMS A2A receptor 3VG9
ICL3 228 G - - - -
ICL3 229 S - - - -
ICL3 230 N - - - -
ICL3 231 A - - - -
ICL3 232 T - - - -
ICL3 233 G - - - -
ICL3 234 S - - - -
ICL3 235 R - - - -
ICL3 236 D - - - -
TM6 237 P 6.29x29 CXCR4 3ODU P2Y1 receptor 4XNW
TM6 238 S 6.30x30 CXCR4 3ODU C5a1 receptor 6C1R
TM6 239 M 6.31x31 CXCR4 3ODU LPA1 receptor 4Z35
TM6 240 K 6.32x32 CXCR4 3ODU CXCR4 3ODU
TM6 241 A 6.33x33 CXCR4 3ODU CXCR4 3ODU
TM6 242 H 6.34x34 CXCR4 3ODU - -
TM6 243 I 6.35x35 CXCR4 3ODU Y1 receptor 5ZBH
TM6 244 G 6.36x36 CXCR4 3ODU CysLT1 receptor 6RZ4
TM6 245 A 6.37x37 CXCR4 3ODU D2 receptor 6CM4
TM6 246 I 6.38x38 CXCR4 3ODU NK1 receptor 6HLP
TM6 247 K 6.39x39 CXCR4 3ODU - -
TM6 248 A 6.40x40 CXCR4 3ODU succinate receptor 6RNK
TM6 249 T 6.41x41 CXCR4 3ODU CysLT2 receptor 6RZ6
TM6 250 S 6.42x42 CXCR4 3ODU S1P1 receptor 3V2Y
TM6 251 Y 6.43x43 CXCR4 3ODU - -
TM6 252 F 6.44x44 CXCR4 3ODU CXCR4 3ODU
TM6 253 L 6.45x45 CXCR4 3ODU 5-HT2C receptor 6BQH
TM6 254 I 6.46x46 CXCR4 3ODU 5-HT2C receptor 6BQH
TM6 255 L 6.47x47 CXCR4 3ODU succinate receptor 6RNK
TM6 256 Y 6.48x48 CXCR4 3ODU OX1 receptor 6TO7
TM6 257 I 6.49x49 CXCR4 3ODU AT1 receptor 4ZUD
TM6 258 F 6.50x50 CXCR4 3ODU - -
TM6 259 N 6.51x51 CXCR4 3ODU - -
TM6 260 A 6.52x52 CXCR4 3ODU Rhodopsin 4ZWJ
TM6 261 I 6.53x53 CXCR4 3ODU CXCR4 3ODU
TM6 262 A 6.54x54 CXCR4 3ODU ETB receptor 5X93
TM6 263 L 6.55x55 CXCR4 3ODU CXCR2 6LFL
TM6 264 F 6.56x56 CXCR4 3ODU AT1 receptor 4ZUD
TM6 265 L 6.57x57 CXCR4 3ODU 5-HT2C receptor 6BQH
TM6 266 S 6.58x58 CXCR4 3ODU 5-HT2C receptor 6BQH
TM6 267 T 6.59x59 CXCR4 3ODU M2 receptor 5ZKC
TM6 268 S 6.60x60 CXCR4 3ODU BLT1 receptor 5X33
TM6 269 N 6.61x61 CXCR4 3ODU - -
ECL3 270 I CXCR4 3ODU CXCR4 3ODU
ECL3 271 F CXCR4 3ODU - -
ECL3 272 D CXCR4 3ODU - -
ECL3 273 T CXCR4 3ODU - -
TM7 274 Y 7.31x31 CXCR4 3ODU OX1 receptor 6TO7
TM7 275 S 7.32x32 CXCR4 3ODU κ receptor 4DJH
TM7 276 S 7.33x33 CXCR4 3ODU κ receptor 6VI4
TM7 277 W 7.34x34 CXCR4 3ODU M2 receptor 5ZKC
TM7 278 N 7.35x35 CXCR4 3ODU 5-HT2C receptor 6BQH
TM7 279 I 7.36x36 CXCR4 3ODU CXCR4 3ODU
TM7 280 L 7.37x37 CXCR4 3ODU β2-adrenoceptor 5JQH
TM7 281 C 7.38x38 CXCR4 3ODU - -
TM7 282 K 7.39x39 CXCR4 3ODU - -
TM7 283 I 7.40x40 CXCR4 3ODU 5-HT2C receptor 6BQH
TM7 284 I 7.41x41 CXCR4 3ODU MC4 receptor 6W25
TM7 285 M 7.42x42 CXCR4 3ODU Y1 receptor 5ZBH
TM7 286 A 7.43x43 CXCR4 3ODU 5-HT2A receptor 6WGT
TM7 287 A 7.44x44 - - - -
TM7 288 Y 7.45x45 CXCR4 3ODU - -
TM7 289 P 7.46x46 CXCR4 3ODU EP4 receptor 5YWY
TM7 290 A 7.47x47 CXCR4 3ODU 5-HT2A receptor 6A94
TM7 291 G 7.48x48 CXCR4 3ODU - -
TM7 292 H 7.49x49 CXCR4 3ODU - -
TM7 293 S 7.50x50 CXCR4 3ODU - -
TM7 294 V 7.51x51 CXCR4 3ODU M3 receptor 5ZHP
TM7 295 Q 7.52x52 5-HT2C receptor 6BQH - -
TM7 296 L 7.53x53 5-HT2C receptor 6BQH ETB receptor 5X93
TM7 297 I 7.54x54 5-HT2C receptor 6BQH EP4 receptor 5YWY
TM7 298 L 7.55x55 5-HT2C receptor 6BQH 5-HT2C receptor 6BQH
TM7 299 G 7.56x56 5-HT2C receptor 6BQH GPBA receptor 7CFN
H8 300 N 8.47x47 5-HT2C receptor 6BQH 5-HT2C receptor 6BQH
H8 301 P 8.48x48 5-HT2C receptor 6BQH DP2 receptor 6D27
H8 302 G 8.49x49 5-HT2C receptor 6BQH - -
H8 303 L 8.50x50 5-HT2C receptor 6BQH CB1 receptor 5TGZ
H8 304 R 8.51x51 5-HT2C receptor 6BQH 5-HT2C receptor 6BQH
H8 305 R 8.52x52 5-HT2C receptor 6BQH 5-HT2C receptor 6BQH
H8 306 A 8.53x53 5-HT2C receptor 6BQH 5-HT2C receptor 6BQH
H8 307 W 8.54x54 5-HT2C receptor 6BQH - -
H8 308 K 8.55x55 5-HT2C receptor 6BQH M2 receptor 5ZKC
H8 309 R 8.56x56 5-HT2C receptor 6BQH 5-HT2A receptor 6A94
H8 310 F 8.57x57 5-HT2C receptor 6BQH Y1 receptor 5ZBQ
H8 311 Q 8.58x58 5-HT2C receptor 6BQH - -
H8 312 H 8.59x59 5-HT2C receptor 6BQH D2 receptor 6LUQ
H8 313 Q 8.60x60 5-HT2C receptor 6BQH succinate receptor 6IBB
C-term 314 V - - - -
C-term 315 P - - - -
C-term 316 L - - - -
C-term 317 Y - - - -
C-term 318 L - - - -