G12 - HCA2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM3 R 128 3x53 G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 132 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 132 34x50 G.H5 L 371 G.H5.16
Polar ICL2 K 138 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 138 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 K 138 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 Y 295 7x54 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 295 7x54 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 132 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 A 135 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 135 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic TM6 K 225 6x29 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 Q 381 G.H5.26
Hydrophobic TM7 S 297 7x56 G.H5 I 378 G.H5.23
Van-der-waals TM7 S 297 7x56 G.H5 I 378 G.H5.23
Hydrophobic TM7 F 296 7x55 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 296 7x55 G.H5 L 380 G.H5.25
Polar ICL2 H 133 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 H 133 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 H 133 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 H 133 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 H 133 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL3 M 220 - G.H5 Q 372 G.H5.17
Polar TM3 R 128 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 R 128 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 V 129 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 129 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 H 133 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM6 I 233 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 I 233 6x37 G.H5 M 379 G.H5.24
Hydrophobic H8 S 298 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 H 133 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 L 215 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 215 5x65 G.H5 L 375 G.H5.20
Hydrophobic H8 P 302 8x51 G.H5 L 380 G.H5.25
Van-der-waals H8 P 302 8x51 G.H5 L 380 G.H5.25
Hydrophobic TM3 V 129 3x54 G.H5 M 379 G.H5.24
Hydrophobic TM3 R 125 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 I 378 G.H5.23
Ionic TM5 R 218 5x68 G.H5 D 368 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM4 S 140 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 S 140 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic H8 P 299 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 229 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 229 6x33 G.H5 M 379 G.H5.24
Polar ICL2 I 139 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 133 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 133 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL3 M 220 - G.H5 L 375 G.H5.20
Hydrophobic ICL3 M 220 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 M 220 - G.H5 L 371 G.H5.16
Ionic TM2 K 60 2x37 G.H5 D 377 G.H5.22
Polar TM2 K 60 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM3 R 128 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 128 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM5 R 218 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 R 218 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM6 I 226 6x30 G.H5 L 375 G.H5.20
Polar ICL2 P 132 34x50 G.H5 N 374 G.H5.19