G12 - V2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 G 151 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 G 151 34x57 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 G 151 34x57 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 I 74 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM6 A 265 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 265 6x29 G.H5 M 379 G.H5.24
Van-der-waals ICL1 H 70 - G.hns1 R 55 G.hns1.02
Hydrophobic TM3 R 137 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 R 149 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 R 149 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM3 I 141 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM2 I 78 2x43 G.H5 L 380 G.H5.25
Polar TM3 A 140 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 M 145 34x51 G.H5 K 367 G.H5.12
Polar ICL3 E 258 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL3 E 258 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 E 258 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 R 149 34x55 G.S3 I 221 G.S3.01
Van-der-waals ICL2 R 149 34x55 G.S3 I 221 G.S3.01
Polar TM6 K 268 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 268 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 268 6x32 G.H5 M 379 G.H5.24
Polar H8 S 330 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 330 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 S 330 8x48 G.H5 Q 381 G.H5.26
Polar ICL3 E 258 - G.S6 L 346 G.S6.01
Ionic C-term E 356 - G.H3 K 284 G.H3.16
Polar C-term E 356 - G.H3 K 284 G.H3.16
Hydrophobic C-term E 356 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 356 - G.H3 K 284 G.H3.16
Hydrophobic C-term C 358 - G.H3 K 284 G.H3.16
Hydrophobic C-term T 360 - G.H2 Q 236 G.H2.05
Van-der-waals C-term T 360 - G.H2 Q 236 G.H2.05
Hydrophobic TM5 S 235 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL3 E 258 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 E 258 - G.h4s6 K 344 G.h4s6.19
Hydrophobic TM3 I 141 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM5 P 240 5x73 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 P 240 5x73 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 I 232 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 Y 148 34x54 G.S1 V 58 G.S1.02
Van-der-waals ICL2 Y 148 34x54 G.S1 V 58 G.S1.02
Polar C-term S 357 - G.H3 K 284 G.H3.16
Hydrophobic C-term S 357 - G.H3 K 284 G.H3.16
Van-der-waals C-term S 357 - G.H3 K 284 G.H3.16
Hydrophobic ICL2 M 145 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 M 145 34x51 G.S3 I 221 G.S3.01
Polar ICL2 H 150 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 150 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 150 34x56 G.hns1 R 56 G.hns1.03
Polar ICL2 A 147 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals TM6 T 269 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 144 34x50 G.H5 K 367 G.H5.12
Ionic ICL3 E 258 - G.h4s6 R 339 G.h4s6.08
Polar ICL3 E 258 - G.h4s6 R 339 G.h4s6.08
Polar ICL1 H 70 - G.HN R 51 G.HN.51
Hydrophobic ICL1 H 70 - G.HN R 51 G.HN.51
Van-der-waals ICL1 H 70 - G.HN R 51 G.HN.51
Hydrophobic TM3 I 141 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 141 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 Y 148 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Y 148 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 I 74 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 74 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 Y 148 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Y 148 34x54 G.H5 I 370 G.H5.15
Ionic TM5 E 231 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 231 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM5 P 240 5x73 G.S6 F 347 G.S6.02
Van-der-waals TM5 P 240 5x73 G.S6 F 347 G.S6.02
Hydrophobic H8 S 329 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 329 8x47 G.H5 L 380 G.H5.25
Polar H8 S 330 8x48 G.H5 L 380 G.H5.25
Hydrophobic H8 S 330 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 S 330 8x48 G.H5 L 380 G.H5.25
Polar TM4 H 155 4x41 G.HN R 52 G.HN.52
Hydrophobic TM4 H 155 4x41 G.HN R 52 G.HN.52
Van-der-waals TM4 H 155 4x41 G.HN R 52 G.HN.52
Hydrophobic ICL2 M 145 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 M 145 34x51 G.H5 F 363 G.H5.08
Polar TM4 S 152 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 S 152 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 S 152 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 A 154 4x40 G.hns1 R 56 G.hns1.03
Polar ICL2 R 149 34x55 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 R 149 34x55 G.s2s3 K 219 G.s2s3.01
Polar TM5 R 243 5x76 G.H5 H 364 G.H5.09
Aromatic TM5 R 243 5x76 G.H5 H 364 G.H5.09
Hydrophobic TM5 R 243 5x76 G.H5 H 364 G.H5.09
Van-der-waals TM5 R 243 5x76 G.H5 H 364 G.H5.09
Hydrophobic TM3 A 140 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 140 3x53 G.H5 I 378 G.H5.23
Ionic TM5 R 243 5x76 G.H5 D 368 G.H5.13
Hydrophobic TM4 G 153 4x39 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 G 153 4x39 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 144 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 144 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM7 F 328 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 328 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 M 145 34x51 G.S3 F 223 G.S3.03
Polar C-term C 358 - G.H3 N 283 G.H3.15
Hydrophobic C-term C 358 - G.H3 N 283 G.H3.15
Van-der-waals C-term C 358 - G.H3 N 283 G.H3.15
Hydrophobic ICL2 Y 148 34x54 G.S3 I 221 G.S3.01
Hydrophobic ICL2 P 144 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 M 145 34x51 G.H5 V 366 G.H5.11
Polar TM6 K 268 6x32 G.H5 L 380 G.H5.25
Hydrophobic TM5 S 241 5x74 G.S6 H 348 G.S6.03
Van-der-waals TM5 S 241 5x74 G.S6 H 348 G.S6.03
Hydrophobic ICL2 M 145 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 145 34x51 G.H5 I 370 G.H5.15