Gz - V2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 G 153 4x39 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 G 153 4x39 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 144 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 144 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL2 H 150 34x56 G.S2 T 191 G.S2.07
Hydrophobic ICL2 M 145 34x51 G.H5 V 340 G.H5.11
Polar TM5 S 235 5x68 G.H5 D 342 G.H5.13
Hydrophobic ICL3 P 244 - G.S6 F 324 G.S6.05
Hydrophobic ICL2 M 145 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM3 I 141 3x54 G.H5 N 348 G.H5.19
Ionic TM5 E 242 5x75 G.S6 H 323 G.S6.04
Polar TM5 E 242 5x75 G.S6 H 323 G.S6.04
Hydrophobic C-term T 360 - G.H2 K 210 G.H2.05
Van-der-waals C-term T 360 - G.H2 K 210 G.H2.05
Van-der-waals TM6 A 265 6x29 G.H5 L 354 G.H5.25
Van-der-waals TM7 F 328 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM2 A 72 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 A 72 2x37 G.H5 Y 351 G.H5.22
Hydrophobic ICL2 R 149 34x55 G.S3 L 195 G.S3.01
Hydrophobic TM2 I 74 2x39 G.H5 I 352 G.H5.23
Polar ICL2 R 149 34x55 G.s2s3 K 193 G.s2s3.01
Hydrophobic TM3 A 140 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL2 P 144 34x50 G.H5 T 341 G.H5.12
Ionic TM6 H 261 6x25 G.h4s6 E 316 G.h4s6.09
Polar TM6 H 261 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 H 261 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 H 261 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic ICL2 M 145 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 M 145 34x51 G.H5 T 341 G.H5.12
Hydrophobic ICL2 Y 148 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 Y 148 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM5 E 242 5x75 G.H5 F 335 G.H5.06
Van-der-waals TM5 E 242 5x75 G.H5 F 335 G.H5.06
Polar TM6 K 268 6x32 G.H5 G 353 G.H5.24
Hydrophobic TM6 K 268 6x32 G.H5 G 353 G.H5.24
Van-der-waals TM6 K 268 6x32 G.H5 G 353 G.H5.24
Van-der-waals C-term S 357 - G.H3 N 258 G.H3.16
Hydrophobic TM5 P 240 5x73 G.S6 Y 321 G.S6.02
Van-der-waals TM5 P 240 5x73 G.S6 Y 321 G.S6.02
Hydrophobic TM6 K 268 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM6 K 268 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 141 3x54 G.H5 I 352 G.H5.23
Polar TM6 K 268 6x32 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 268 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 268 6x32 G.H5 C 355 G.H5.26
Hydrophobic ICL2 M 145 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 M 145 34x51 G.S3 L 195 G.S3.01
Ionic ICL2 R 149 34x55 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 149 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 149 34x55 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 149 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL3 P 244 - G.H4 V 302 G.H4.08
Van-der-waals ICL3 P 244 - G.H4 V 302 G.H4.08
Hydrophobic TM6 M 272 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 272 6x36 G.H5 L 354 G.H5.25
Polar C-term E 356 - G.H3 N 258 G.H3.16
Hydrophobic C-term E 356 - G.H3 N 258 G.H3.16
Van-der-waals C-term E 356 - G.H3 N 258 G.H3.16
Hydrophobic TM6 T 269 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 269 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 M 145 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 M 145 34x51 G.H5 I 344 G.H5.15
Polar TM4 S 152 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 S 152 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 S 152 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 A 265 6x29 G.H5 C 355 G.H5.26
Polar ICL2 H 150 34x56 G.S3 T 196 G.S3.02
Hydrophobic ICL2 H 150 34x56 G.S3 T 196 G.S3.02
Van-der-waals ICL2 H 150 34x56 G.S3 T 196 G.S3.02
Van-der-waals ICL2 Y 148 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 M 145 34x51 G.S1 I 34 G.S1.02
Polar TM2 P 73 2x38 G.H5 Y 351 G.H5.22
Hydrophobic TM2 P 73 2x38 G.H5 Y 351 G.H5.22
Van-der-waals TM2 P 73 2x38 G.H5 Y 351 G.H5.22
Hydrophobic TM3 I 141 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 141 3x54 G.H5 L 349 G.H5.20
Polar TM5 E 242 5x75 G.S6 S 322 G.S6.03
Hydrophobic ICL2 P 144 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 144 34x50 G.H5 I 345 G.H5.16
Hydrophobic C-term D 355 - G.H3 N 258 G.H3.16
Hydrophobic TM5 P 240 5x73 G.h4s6 E 319 G.h4s6.12
Polar ICL2 H 150 34x56 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 H 150 34x56 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 H 150 34x56 G.s2s3 E 194 G.s2s3.02
Polar TM5 E 242 5x75 G.H4 Q 305 G.H4.12
Polar TM3 A 140 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 140 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 140 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 Y 148 34x54 G.S1 I 34 G.S1.02
Hydrophobic ICL2 Y 148 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic C-term L 365 - G.H3 R 249 G.H3.07
Van-der-waals C-term L 365 - G.H3 R 249 G.H3.07
Hydrophobic ICL2 Y 148 34x54 G.H5 I 344 G.H5.15
Van-der-waals ICL2 Y 148 34x54 G.H5 I 344 G.H5.15
Hydrophobic TM2 I 74 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM5 I 232 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 I 232 5x65 G.H5 L 349 G.H5.20
Polar TM3 R 137 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 137 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 137 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM5 P 240 5x73 G.S6 I 320 G.S6.01