GPR132 homology model

PROTEIN CLASS

Class A (Rhodopsin)

RECEPTOR

GPR132

SPECIES

Homo sapiens

STATE

Inactive

VERSION

2020-09-02

MODEL

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PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

CCR7 (sequence similarity: 41%) PDB: 6QZH
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TEMPLATES

5NDD (PAR2)
6QZH (CCR7)
5XSZ (LPA6 receptor)
5X33 (BLT1 receptor)
6JOD (AT2 receptor)
5WB1 (US28)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 72.2 17.4 10.4
Side-chains 21.4 57.2 21.4

Number of backbone templates: 6
Number of rotamer templates: 50

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 33 C PAR2 5NDD PAR2 5NDD
N-term 34 N PAR2 5NDD PAR2 5NDD
N-term 35 N PAR2 5NDD PAR2 5NDD
N-term 36 V PAR2 5NDD PAR2 5NDD
N-term 37 S PAR2 5NDD PAR2 5NDD
TM1 38 F 1.28x28 PAR2 5NDD - -
TM1 39 E 1.29x29 PAR2 5NDD ETB receptor 5X93
TM1 40 E 1.30x30 CCR7 6QZH - -
TM1 41 S 1.31x31 CCR7 6QZH NTS1 receptor 4BUO
TM1 42 R 1.32x32 CCR7 6QZH CysLT2 receptor 6RZ6
TM1 43 I 1.33x33 CCR7 6QZH μ receptor 4DKL
TM1 44 V 1.34x34 CCR7 6QZH OX2 receptor 5WS3
TM1 45 L 1.35x35 CCR7 6QZH CCR7 6QZH
TM1 46 V 1.36x36 CCR7 6QZH DP2 receptor 6D27
TM1 47 V 1.37x37 CCR7 6QZH ETB receptor 5X93
TM1 48 V 1.38x38 CCR7 6QZH ETB receptor 5X93
TM1 49 Y 1.39x39 CCR7 6QZH CCR7 6QZH
TM1 50 S 1.40x40 CCR7 6QZH CCR7 6QZH
TM1 51 A 1.41x41 CCR7 6QZH δ receptor 4EJ4
TM1 52 V 1.42x42 CCR7 6QZH apelin receptor 5VBL
TM1 53 C 1.43x43 CCR7 6QZH CCR7 6QZH
TM1 54 T 1.44x44 CCR7 6QZH CB1 receptor 5TGZ
TM1 55 L 1.45x45 CCR7 6QZH DP2 receptor 6D27
TM1 56 G 1.46x46 CCR7 6QZH CCR7 6QZH
TM1 57 V 1.47x47 CCR7 6QZH C5a1 receptor 5O9H
TM1 58 P 1.48x48 CCR7 6QZH BLT1 receptor 5X33
TM1 59 A 1.49x49 CCR7 6QZH LPA1 receptor 4Z35
TM1 60 N 1.50x50 CCR7 6QZH CCR7 6QZH
TM1 61 C 1.51x51 CCR7 6QZH NOP receptor 5DHG
TM1 62 L 1.52x52 CCR7 6QZH CCR7 6QZH
TM1 63 T 1.53x53 CCR7 6QZH NTS1 receptor 4BUO
TM1 64 A 1.54x54 CCR7 6QZH NTS1 receptor 6PWC
TM1 65 W 1.55x55 CCR7 6QZH BLT1 receptor 5X33
TM1 66 L 1.56x56 CCR7 6QZH CB2 receptor 5ZTY
TM1 67 A 1.57x57 CCR7 6QZH FPR2/ALX 6LW5
TM1 68 L 1.58x58 CCR7 6QZH BLT1 receptor 5X33
TM1 69 L 1.59x59 CCR7 6QZH A2A receptor 5IU4
TM1 70 Q 1.60x60 LPA6 receptor 5XSZ CXCR4 3OE0
ICL1 71 V - - - -
ICL1 72 L LPA6 receptor 5XSZ - -
ICL1 73 Q LPA6 receptor 5XSZ - -
ICL1 74 G - - - -
TM2 75 N 2.37x37 CCR7 6QZH 5-HT2A receptor 6A94
TM2 76 V 2.38x38 CCR7 6QZH AT1 receptor 4ZUD
TM2 77 L 2.39x39 CCR7 6QZH OT receptor 6TPK
TM2 78 A 2.40x40 CCR7 6QZH BLT1 receptor 5X33
TM2 79 V 2.41x41 CCR7 6QZH AT1 receptor 4ZUD
TM2 80 Y 2.42x42 CCR7 6QZH CCR7 6QZH
TM2 81 L 2.43x43 CCR7 6QZH CCR7 6QZH
TM2 82 L 2.44x44 CCR7 6QZH CCR7 6QZH
TM2 83 C 2.45x45 CCR7 6QZH - -
TM2 84 L 2.46x46 CCR7 6QZH CCR7 6QZH
TM2 85 A 2.47x47 CCR7 6QZH CCR7 6QZH
TM2 86 L 2.48x48 CCR7 6QZH AT1 receptor 4ZUD
TM2 87 C 2.49x49 CCR7 6QZH - -
TM2 88 E 2.50x50 CCR7 6QZH NK1 receptor 6HLP
TM2 89 L 2.51x51 CCR7 6QZH AT1 receptor 4ZUD
TM2 90 L 2.52x52 CCR7 6QZH CCR7 6QZH
TM2 91 Y 2.53x53 CCR7 6QZH P2Y1 receptor 4XNW
TM2 92 T 2.54x54 CCR7 6QZH μ receptor 4DKL
TM2 93 G 2.55x55 CCR7 6QZH - -
TM2 94 T 2.56x56 CCR7 6QZH CCR7 6QZH
TM2 95 L 2.57x57 CCR7 6QZH CCR7 6QZH
TM2 96 P 2.58x58 CCR7 6QZH CCR7 6QZH
TM2 97 L 2.59x59 CCR7 6QZH AT1 receptor 4ZUD
TM2 98 W 2.60x60 CCR7 6QZH CCR7 6QZH
TM2 99 V 2.61x61 CCR7 6QZH ETB receptor 5X93
TM2 100 I 2.62x62 CCR7 6QZH CCR9 5LWE
TM2 101 Y 2.63x63 CCR7 6QZH AT1 receptor 4ZUD
TM2 102 I 2.64x64 CCR7 6QZH C5a1 receptor 5O9H
TM2 103 R 2.65x65 CCR7 6QZH - -
TM2 104 N 2.66x66 CCR7 6QZH CCR2 5T1A
ECL1 105 Q - - - -
ECL1 106 H - - - -
ECL1 107 R 23.49x49 LPA6 receptor 5XSZ AT1 receptor 4ZUD
ECL1 108 W 23.50x50 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ECL1 109 T 23.51x51 LPA6 receptor 5XSZ 5-HT1B receptor 4IAQ
ECL1 110 L 23.52x52 - - - -
TM3 111 G 3.21x21 CCR7 6QZH CCR7 6QZH
TM3 112 L 3.22x22 CCR7 6QZH BLT1 receptor 5X33
TM3 113 L 3.23x23 CCR7 6QZH δ receptor 4EJ4
TM3 114 A 3.24x24 CCR7 6QZH C5a1 receptor 5O9H
TM3 115 C 3.25x25 CCR7 6QZH CCR7 6QZH
TM3 116 K 3.26x26 CCR7 6QZH CCR7 6QZH
TM3 117 V 3.27x27 CCR7 6QZH CCR9 5LWE
TM3 118 T 3.28x28 CCR7 6QZH P2Y12 receptor 4NTJ
TM3 119 A 3.29x29 CCR7 6QZH MT1 receptor 6ME2
TM3 120 Y 3.30x30 CCR7 6QZH BLT1 receptor 5X33
TM3 121 I 3.31x31 CCR7 6QZH CCR7 6QZH
TM3 122 F 3.32x32 CCR7 6QZH DP2 receptor 6D27
TM3 123 F 3.33x33 CCR7 6QZH DP2 receptor 6D27
TM3 124 C 3.34x34 CCR7 6QZH PAR1 3VW7
TM3 125 N 3.35x35 CCR7 6QZH AT1 receptor 4ZUD
TM3 126 I 3.36x36 CCR7 6QZH Y1 receptor 5ZBH
TM3 127 Y 3.37x37 CCR7 6QZH AT1 receptor 4ZUD
TM3 128 V 3.38x38 CCR7 6QZH OX2 receptor 5WS3
TM3 129 S 3.39x39 CCR7 6QZH AT1 receptor 4ZUD
TM3 130 I 3.40x40 CCR7 6QZH CCR5 5UIW
TM3 131 L 3.41x41 CCR7 6QZH BLT1 receptor 5X33
TM3 132 F 3.42x42 CCR7 6QZH CCR5 5UIW
TM3 133 L 3.43x43 CCR7 6QZH CCR7 6QZH
TM3 134 C 3.44x44 CCR7 6QZH μ receptor 4DKL
TM3 135 C 3.45x45 CCR7 6QZH CCR7 6QZH
TM3 136 I 3.46x46 CCR7 6QZH CCR7 6QZH
TM3 137 S 3.47x47 CCR7 6QZH CCR7 6QZH
TM3 138 C 3.48x48 CCR7 6QZH - -
TM3 139 D 3.49x49 CCR7 6QZH CCR7 6QZH
TM3 140 R 3.50x50 CCR7 6QZH CCR7 6QZH
TM3 141 F 3.51x51 CCR7 6QZH C5a1 receptor 5O9H
TM3 142 V 3.52x52 CCR7 6QZH CCR7 6QZH
TM3 143 A 3.53x53 CCR7 6QZH CCR7 6QZH
TM3 144 V 3.54x54 CCR7 6QZH DP2 receptor 6D27
TM3 145 V 3.55x55 CCR7 6QZH CCR7 6QZH
TM3 146 Y 3.56x56 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 147 A - - - -
ICL2 148 L LPA6 receptor 5XSZ - -
ICL2 149 E LPA6 receptor 5XSZ - -
ICL2 150 S LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 151 R LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 152 G LPA6 receptor 5XSZ LPA6 receptor 5XSZ
ICL2 153 R LPA6 receptor 5XSZ - -
ICL2 154 R - - - -
TM4 155 R 4.38x38 CCR7 6QZH CCR9 5LWE
TM4 156 R 4.39x39 CCR7 6QZH apelin receptor 5VBL
TM4 157 R 4.40x40 CCR7 6QZH μ receptor 4DKL
TM4 158 T 4.41x41 CCR7 6QZH OT receptor 6TPK
TM4 159 A 4.42x42 CCR7 6QZH AT1 receptor 4ZUD
TM4 160 I 4.43x43 CCR7 6QZH 5-HT2C receptor 6BQH
TM4 161 L 4.44x44 CCR7 6QZH CCR7 6QZH
TM4 162 I 4.45x45 CCR7 6QZH δ receptor 4EJ4
TM4 163 S 4.46x46 CCR7 6QZH CCR5 5UIW
TM4 164 A 4.47x47 CCR7 6QZH apelin receptor 5VBL
TM4 165 C 4.48x48 CCR7 6QZH μ receptor 4DKL
TM4 166 I 4.49x49 CCR7 6QZH CCR7 6QZH
TM4 167 F 4.50x50 CCR7 6QZH - -
TM4 168 I 4.51x51 CCR7 6QZH CCR7 6QZH
TM4 169 L 4.52x52 CCR7 6QZH CCR7 6QZH
TM4 170 V 4.53x53 CCR7 6QZH LPA6 receptor 5XSZ
TM4 171 G 4.54x54 CCR7 6QZH AT1 receptor 4ZUD
TM4 172 I 4.55x55 CCR7 6QZH OX2 receptor 5WS3
TM4 173 V 4.56x56 CCR7 6QZH δ receptor 4EJ4
TM4 174 H 4.57x57 CCR7 6QZH - -
TM4 175 Y 4.58x59 CCR7 6QZH PAF receptor 5ZKQ
TM4 176 P 4.59x60 CCR7 6QZH CCR7 6QZH
TM4 177 V 4.60x61 CCR7 6QZH BLT1 receptor 5X33
TM4 178 F 4.61x62 CCR7 6QZH DP2 receptor 6D27
TM4 179 Q 4.62x63 CCR7 6QZH - -
ECL2 180 T - - - -
ECL2 181 E - - - -
ECL2 182 D - - - -
ECL2 183 K - - - -
ECL2 184 E - - - -
ECL2 185 T - - - -
ECL2 186 C 45.50x50 CCR7 6QZH CCR7 6QZH
ECL2 187 F 45.51x51 CCR7 6QZH Y1 receptor 5ZBH
ECL2 188 D 45.52x52 CCR7 6QZH Y1 receptor 5ZBH
ECL2 189 M - - - -
ECL2 190 L BLT1 receptor 5X33 - -
ECL2 191 Q - - - -
TM5 192 M 5.31x32 LPA6 receptor 5XSZ ETB receptor 5X93
TM5 193 D 5.32x33 LPA6 receptor 5XSZ BLT1 receptor 5X33
TM5 194 S 5.33x34 LPA6 receptor 5XSZ LPA6 receptor 5XSZ
TM5 195 R 5.34x35 LPA6 receptor 5XSZ DP2 receptor 6D27
TM5 196 I 5.35x36 CCR7 6QZH - -
TM5 197 A 5.36x37 CCR7 6QZH DP2 receptor 6D27
TM5 198 G 5.37x38 CCR7 6QZH AT1 receptor 4ZUD
TM5 199 Y 5.38x39 CCR7 6QZH OX2 receptor 5WS3
TM5 200 Y 5.39x40 CCR7 6QZH - -
TM5 201 Y 5.40x41 CCR7 6QZH EP4 receptor 5YWY
TM5 202 A 5.41x42 CCR7 6QZH CCR7 6QZH
TM5 203 R 5.42x43 CCR7 6QZH CCR2 5T1A
TM5 204 F 5.43x44 CCR7 6QZH DP2 receptor 6D27
TM5 205 T 5.44x45 CCR7 6QZH apelin receptor 5VBL
TM5 206 V 5.45x46 CCR7 6QZH apelin receptor 5VBL
TM5 207 G 5.46x461 CCR7 6QZH CCR7 6QZH
TM5 208 F 5.47x47 CCR7 6QZH CCR7 6QZH
TM5 209 A 5.48x48 CCR7 6QZH OX2 receptor 6TPN
TM5 210 I 5.49x49 CCR7 6QZH 5-HT2A receptor 6A94
TM5 211 P 5.50x50 CCR7 6QZH CCR7 6QZH
TM5 212 L 5.51x51 CCR7 6QZH CCR7 6QZH
TM5 213 S 5.52x52 CCR7 6QZH M5 receptor 6OL9
TM5 214 I 5.53x53 CCR7 6QZH AT1 receptor 4ZUD
TM5 215 I 5.54x54 CCR7 6QZH AT1 receptor 4ZUD
TM5 216 A 5.55x55 CCR7 6QZH DP2 receptor 6D27
TM5 217 F 5.56x56 CCR7 6QZH CCR7 6QZH
TM5 218 T 5.57x57 CCR7 6QZH 5-HT2A receptor 6A94
TM5 219 N 5.58x58 CCR7 6QZH NTS1 receptor 4BUO
TM5 220 H 5.59x59 CCR7 6QZH - -
TM5 221 R 5.60x60 CCR7 6QZH M5 receptor 6OL9
TM5 222 I 5.61x61 CCR7 6QZH CCR7 6QZH
TM5 223 F 5.62x62 CCR7 6QZH OX2 receptor 5WS3
TM5 224 R 5.63x63 LPA6 receptor 5XSZ BLT1 receptor 5X33
TM5 225 S 5.64x64 LPA6 receptor 5XSZ 5-HT2A receptor 6A94
TM5 226 I 5.65x65 LPA6 receptor 5XSZ apelin receptor 5VBL
TM5 227 K 5.66x66 LPA6 receptor 5XSZ κ receptor 4DJH
TM5 228 Q 5.67x67 LPA6 receptor 5XSZ - -
ICL3 229 S - - - -
ICL3 230 M - - - -
ICL3 231 G - - - -
ICL3 232 L - - - -
TM6 233 S 6.26x26 AT2 receptor 6JOD 5-HT2A receptor 6A94
TM6 234 A 6.27x27 AT2 receptor 6JOD 5-HT1B receptor 4IAQ
TM6 235 A 6.28x28 AT2 receptor 6JOD 5-HT1B receptor 4IAQ
TM6 236 Q 6.29x29 AT2 receptor 6JOD CXCR4 3ODU
TM6 237 K 6.30x30 AT2 receptor 6JOD CCR9 5LWE
TM6 238 A 6.31x31 AT2 receptor 6JOD - -
TM6 239 K 6.32x32 AT2 receptor 6JOD CCR9 5LWE
TM6 240 V 6.33x33 AT2 receptor 6JOD AT2 receptor 6JOD
TM6 241 K 6.34x34 AT2 receptor 6JOD - -
TM6 242 H 6.35x35 CCR7 6QZH - -
TM6 243 S 6.36x36 CCR7 6QZH A1 receptor 5UEN
TM6 244 A 6.37x37 CCR7 6QZH D2 receptor 6CM4
TM6 245 I 6.38x38 CCR7 6QZH CCR7 6QZH
TM6 246 A 6.39x39 CCR7 6QZH CCR7 6QZH
TM6 247 V 6.40x40 CCR7 6QZH CCR7 6QZH
TM6 248 V 6.41x41 CCR7 6QZH CCR7 6QZH
TM6 249 V 6.42x42 CCR7 6QZH CCR7 6QZH
TM6 250 I 6.43x43 CCR7 6QZH MT2 receptor 6ME6
TM6 251 F 6.44x44 CCR7 6QZH CCR7 6QZH
TM6 252 L 6.45x45 CCR7 6QZH 5-HT2C receptor 6BQH
TM6 253 V 6.46x46 CCR7 6QZH CCR7 6QZH
TM6 254 C 6.47x47 CCR7 6QZH DP2 receptor 6D27
TM6 255 F 6.48x48 CCR7 6QZH MT1 receptor 6ME2
TM6 256 A 6.49x49 CCR7 6QZH CCR5 5UIW
TM6 257 P 6.50x50 CCR7 6QZH CCR7 6QZH
TM6 258 Y 6.51x51 CCR7 6QZH CCR7 6QZH
TM6 259 H 6.52x52 CCR7 6QZH DP2 receptor 6D27
TM6 260 L 6.53x53 CCR7 6QZH apelin receptor 5VBL
TM6 261 V 6.54x54 CCR7 6QZH CCR7 6QZH
TM6 262 L 6.55x55 CCR7 6QZH CCR5 5UIW
TM6 263 L 6.56x56 CCR7 6QZH CCR7 6QZH
TM6 264 V 6.57x57 CCR7 6QZH BLT1 receptor 5X33
TM6 265 K 6.58x58 CCR7 6QZH μ receptor 4DKL
TM6 266 A 6.59x59 LPA6 receptor 5XSZ DP2 receptor 6D27
TM6 267 A 6.60x60 LPA6 receptor 5XSZ CB2 receptor 5ZTY
TM6 268 A 6.61x61 LPA6 receptor 5XSZ P2Y1 receptor 4XNW
TM6 269 F 6.62x62 LPA6 receptor 5XSZ - -
TM6 270 S 6.63x63 LPA6 receptor 5XSZ - -
TM6 271 Y 6.64x64 LPA6 receptor 5XSZ - -
ECL3 272 Y - - - -
ECL3 273 R - - - -
ECL3 274 G - - - -
ECL3 275 D - - - -
ECL3 276 R - - - -
ECL3 277 N - - - -
ECL3 278 A - - - -
TM7 279 M 7.24x23 LPA6 receptor 5XSZ - -
TM7 280 C 7.25x24 CCR7 6QZH CCR7 6QZH
TM7 281 G 7.26x25 CCR7 6QZH - -
TM7 282 L 7.27x26 CCR7 6QZH CCR7 6QZH
TM7 283 E 7.28x27 CCR7 6QZH CXCR4 3ODU
TM7 284 E 7.29x28 CCR7 6QZH OX2 receptor 5WS3
TM7 285 R 7.30x29 CCR7 6QZH CCR5 5UIW
TM7 286 L 7.31x30 CCR7 6QZH CCR7 6QZH
TM7 287 Y 7.32x31 CCR7 6QZH OX2 receptor 5WS3
TM7 288 T 7.33x32 CCR7 6QZH AT1 receptor 4ZUD
TM7 289 A 7.34x33 CCR7 6QZH CCR7 6QZH
TM7 290 S 7.35x34 CCR7 6QZH GPR52 6LI1
TM7 291 V 7.36x35 CCR7 6QZH MT1 receptor 6ME2
TM7 292 V 7.37x36 CCR7 6QZH CCR7 6QZH
TM7 293 F 7.38x37 CCR7 6QZH 5-HT2A receptor 6A94
TM7 294 L 7.39x38 CCR7 6QZH S1P1 receptor 3V2Y
TM7 295 C 7.40x39 CCR7 6QZH AT1 receptor 4ZUD
TM7 296 L 7.41x40 CCR7 6QZH CCR7 6QZH
TM7 297 S 7.42x41 CCR7 6QZH apelin receptor 5VBL
TM7 298 T 7.43x42 CCR7 6QZH PAR2 5NDD
TM7 299 V 7.44x43 CCR7 6QZH CCR7 6QZH
TM7 300 N 7.45x45 CCR7 6QZH AT1 receptor 4ZUD
TM7 301 G 7.46x46 CCR7 6QZH - -
TM7 302 V 7.47x47 CCR7 6QZH DP2 receptor 6D27
TM7 303 A 7.48x48 CCR7 6QZH DP2 receptor 6D27
TM7 304 D 7.49x49 CCR7 6QZH EP4 receptor 5YWY
TM7 305 P 7.50x50 CCR7 6QZH CCR7 6QZH
TM7 306 I 7.51x51 CCR7 6QZH CCR5 5UIW
TM7 307 I 7.52x52 CCR7 6QZH CCR5 5UIW
TM7 308 Y 7.53x53 CCR7 6QZH CCR7 6QZH
TM7 309 V 7.54x54 CCR7 6QZH DP2 receptor 6D27
TM7 310 L 7.55x55 CCR7 6QZH DP2 receptor 6D27
TM7 311 A 7.56x56 LPA6 receptor 5XSZ C5a1 receptor 5O9H
H8 312 T 8.47x47 PAR2 5NDD - -
H8 313 D 8.48x48 PAR2 5NDD NK1 receptor 6HLP
H8 314 H 8.49x49 CCR7 6QZH succinate receptor 6RNK
H8 315 S 8.50x50 CCR7 6QZH - -
H8 316 R 8.51x51 CCR7 6QZH CCR7 6QZH
H8 317 Q 8.52x52 CCR7 6QZH apelin receptor 5VBL
H8 318 E 8.53x53 CCR7 6QZH OX2 receptor 5WS3
H8 319 V 8.54x54 CCR7 6QZH ghrelin receptor 6KO5
H8 320 S 8.55x55 CCR7 6QZH CCR2 5T1A
H8 321 R 8.56x56 CCR7 6QZH DP2 receptor 6D27
H8 322 I 8.57x57 CCR7 6QZH H1 receptor 3RZE
H8 323 H 8.58x58 CCR7 6QZH - -
H8 324 K 8.59x59 US28 5WB1 CCR9 5LWE
H8 325 G 8.60x60 US28 5WB1 - -
H8 326 W 8.61x61 US28 5WB1 OX2 receptor 6TPN
C-term 327 K - - - -
C-term 328 E - - - -
C-term 329 W - - - -
C-term 330 S - - - -
C-term 331 M - - - -