TAS2R14 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

TAS2R14

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-09-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

D2 receptor (sequence similarity: 21%) PDB: 7JVR
Align

TEMPLATES

7JVR (D2 receptor)
6M9T (EP3 receptor)
6OSA (NTS1 receptor)
5VBL (apelin receptor)
6W25 (MC4 receptor)
6BQH (5-HT2C receptor)
6KO5 (ghrelin receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 78.1 7.3 14.6
Side-chains 8.6 55.3 36.1

Number of backbone templates: 7
Number of rotamer templates: 60

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - - -
N-term 2 G - - - - -
N-term 3 G - - - - -
N-term 4 V - - - - -
N-term 5 I - - - - -
TM1 6 K 1.32x32 D2 receptor 7JVR 5-HT2B receptor 5TVN
TM1 7 S 1.33x33 D2 receptor 7JVR Rhodopsin 4X1H
TM1 8 I 1.34x34 D2 receptor 7JVR κ receptor 6B73
TM1 9 F 1.35x35 D2 receptor 7JVR CysLT2 receptor 6RZ6
TM1 10 T 1.36x36 D2 receptor 7JVR κ receptor 6B73
TM1 11 F 1.37x37 D2 receptor 7JVR US28 5WB1
TM1 12 V 1.38x38 D2 receptor 7JVR MC4 receptor 7AUE
TM1 13 L 1.39x39 D2 receptor 7JVR D2 receptor 7JVR
TM1 14 I 1.40x40 D2 receptor 7JVR OX2 receptor 7L1V
TM1 15 V 1.41x41 D2 receptor 7JVR κ receptor 6B73
TM1 16 E 1.42x42 D2 receptor 7JVR β3-adrenoceptor 7DH5
TM1 17 F 1.43x43 D2 receptor 7JVR κ receptor 6B73
TM1 18 I 1.44x44 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM1 19 I 1.45x45 D2 receptor 7JVR MC4 receptor 7AUE
TM1 20 G 1.46x46 D2 receptor 7JVR κ receptor 6B73
TM1 21 N 1.47x47 D2 receptor 7JVR - -
TM1 22 L 1.48x48 D2 receptor 7JVR MC4 receptor 7AUE
TM1 23 G 1.49x49 D2 receptor 7JVR D2 receptor 7JVR
TM1 24 N 1.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM1 25 S 1.51x51 D2 receptor 7JVR κ receptor 6B73
TM1 26 F 1.52x52 D2 receptor 7JVR 5-HT1B receptor 4IAQ
TM1 27 I 1.53x53 D2 receptor 7JVR DP2 receptor 6D27
TM1 28 A 1.54x54 D2 receptor 7JVR NTS1 receptor 6UP7
TM1 29 L 1.55x55 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM1 30 V 1.56x56 D2 receptor 7JVR κ receptor 6B73
TM1 31 N 1.57x57 D2 receptor 7JVR - -
TM1 32 C 1.58x58 D2 receptor 7JVR EP4 receptor 7D7M
TM1 33 I 1.59x59 D2 receptor 7JVR - -
TM1 34 D 1.60x60 D2 receptor 7JVR - -
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 V 1.62x62 EP3 receptor 6M9T - -
ICL1 37 K 12.48x48 D2 receptor 7JVR D2 receptor 7JVR
ICL1 38 G 12.49x49 D2 receptor 7JVR - -
ICL1 39 R 12.50x50 D2 receptor 7JVR - -
ICL1 40 K 12.51x51 D2 receptor 7JVR M1 receptor 6OIJ
TM2 41 I 2.36x36 NTS1 receptor 6OSA - -
TM2 42 S 2.37x37 D2 receptor 7JVR MC4 receptor 7AUE
TM2 43 S 2.38x38 D2 receptor 7JVR US28 5WB1
TM2 44 V 2.39x39 D2 receptor 7JVR NTS1 receptor 6OSA
TM2 45 D 2.40x40 D2 receptor 7JVR CCR5 7O7F
TM2 46 R 2.41x41 D2 receptor 7JVR - -
TM2 47 I 2.42x42 D2 receptor 7JVR Rhodopsin 4X1H
TM2 48 L 2.43x43 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM2 49 T 2.44x44 D2 receptor 7JVR β3-adrenoceptor 7DH5
TM2 50 A 2.45x45 D2 receptor 7JVR - -
TM2 51 L 2.46x46 D2 receptor 7JVR D2 receptor 7JVR
TM2 52 A 2.47x47 D2 receptor 7JVR D2 receptor 7JVR
TM2 53 I 2.48x48 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM2 54 S 2.49x49 D2 receptor 7JVR CCR5 7O7F
TM2 55 R 2.50x50 D2 receptor 7JVR - -
TM2 56 I 2.51x51 D2 receptor 7JVR CCR6 6WWZ
TM2 57 S 2.52x52 D2 receptor 7JVR FPR2/ALX 6OMM
TM2 58 L 2.53x53 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM2 59 V 2.54x54 D2 receptor 7JVR CCR6 6WWZ
TM2 60 W 2.55x55 apelin receptor 5VBL - -
TM2 61 L 2.56x56 apelin receptor 5VBL - -
TM2 62 I 2.57x57 D2 receptor 7JVR A1 receptor 6D9H
TM2 63 F 2.58x58 D2 receptor 7JVR LPA1 receptor 4Z35
TM2 64 G 2.59x59 D2 receptor 7JVR - -
TM2 65 S 2.60x60 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM2 66 W 2.61x61 D2 receptor 7JVR - -
TM2 67 C 2.62x62 D2 receptor 7JVR - -
TM2 68 V 2.63x63 D2 receptor 7JVR MC4 receptor 7AUE
TM2 69 S 2.64x64 D2 receptor 7JVR Rhodopsin 4X1H
TM2 70 V 2.65x65 D2 receptor 7JVR D2 receptor 7JVR
TM2 71 F 2.66x66 D2 receptor 7JVR 5-HT2B receptor 4NC3
TM2 72 F 2.67x67 D2 receptor 7JVR CB1 receptor 5XRA
ECL1 73 P - - - - -
ECL1 74 A - apelin receptor 5VBL - -
ECL1 75 L - apelin receptor 5VBL - -
ECL1 76 F - apelin receptor 5VBL - -
ECL1 77 A - - - - -
TM3 78 T 3.21x21 D2 receptor 7JVR S1P1 receptor 3V2Y
TM3 79 E 3.22x22 D2 receptor 7JVR δ receptor 6PT2
TM3 80 K 3.23x23 D2 receptor 7JVR 5-HT2A receptor 6A94
TM3 81 M 3.24x24 D2 receptor 7JVR CCR5 7O7F
TM3 82 F 3.25x25 D2 receptor 7JVR CB2 receptor 6PT0
TM3 83 R 3.26x26 D2 receptor 7JVR NTS1 receptor 6OSA
TM3 84 M 3.27x27 D2 receptor 7JVR A1 receptor 6D9H
TM3 85 L 3.28x28 D2 receptor 7JVR CCR5 7O7F
TM3 86 T 3.29x29 D2 receptor 7JVR CCR5 7O7F
TM3 87 N 3.30x30 D2 receptor 7JVR - -
TM3 88 I 3.31x31 D2 receptor 7JVR κ receptor 6B73
TM3 89 W 3.32x32 D2 receptor 7JVR - -
TM3 90 T 3.33x33 D2 receptor 7JVR OX2 receptor 7L1V
TM3 91 V 3.34x34 D2 receptor 7JVR H1 receptor 7DFL
TM3 92 I 3.35x35 D2 receptor 7JVR - -
TM3 93 N 3.36x36 D2 receptor 7JVR - -
TM3 94 H 3.37x37 D2 receptor 7JVR - -
TM3 95 F 3.38x38 D2 receptor 7JVR - -
TM3 96 S 3.39x39 D2 receptor 7JVR D2 receptor 7JVR
TM3 97 V 3.40x40 D2 receptor 7JVR AT1 receptor 6DO1
TM3 98 W 3.41x41 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM3 99 L 3.42x42 D2 receptor 7JVR AT1 receptor 6DO1
TM3 100 A 3.43x43 D2 receptor 7JVR EP3 receptor 6AK3
TM3 101 T 3.44x44 D2 receptor 7JVR κ receptor 6B73
TM3 102 G 3.45x45 D2 receptor 7JVR apelin receptor 5VBL
TM3 103 L 3.46x46 D2 receptor 7JVR CCR5 7O7F
TM3 104 G 3.47x47 D2 receptor 7JVR - -
TM3 105 T 3.48x48 D2 receptor 7JVR - -
TM3 106 F 3.49x49 D2 receptor 7JVR CysLT1 receptor 6RZ4
TM3 107 Y 3.50x50 D2 receptor 7JVR - -
TM3 108 F 3.51x51 D2 receptor 7JVR D4 receptor 5WIV
TM3 109 L 3.52x52 D2 receptor 7JVR CCR5 7O7F
TM3 110 K 3.53x53 D2 receptor 7JVR P2Y12 receptor 4NTJ
TM3 111 I 3.54x54 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM3 112 A 3.55x55 D2 receptor 7JVR D2 receptor 7JVR
TM3 113 N 3.56x56 D2 receptor 7JVR 5-HT2C receptor 6BQG
ICL2 114 F - - - - -
ICL2 115 S - - - - -
ICL2 116 N 34.50x50 D2 receptor 7JVR - -
ICL2 117 S 34.51x51 D2 receptor 7JVR - -
ICL2 118 I 34.52x52 D2 receptor 7JVR - -
ICL2 119 F 34.53x53 D2 receptor 7JVR - -
ICL2 120 L 34.54x54 D2 receptor 7JVR κ receptor 6B73
ICL2 121 Y 34.55x55 - - - -
ICL2 122 L 34.56x56 - - - -
ICL2 123 K 34.57x57 - - - -
TM4 124 W 4.38x38 D2 receptor 7JVR - -
TM4 125 R 4.39x39 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM4 126 V 4.40x40 D2 receptor 7JVR apelin receptor 5VBL
TM4 127 K 4.41x41 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM4 128 K 4.42x42 D2 receptor 7JVR - -
TM4 129 V 4.43x43 D2 receptor 7JVR CCR5 7O7F
TM4 130 V 4.44x44 D2 receptor 7JVR D2 receptor 7JVR
TM4 131 L 4.45x45 D2 receptor 7JVR β1-adrenoceptor 7BU7
TM4 132 V 4.46x46 D2 receptor 7JVR β3-adrenoceptor 7DH5
TM4 133 L 4.47x47 D2 receptor 7JVR H1 receptor 7DFL
TM4 134 L 4.48x48 D2 receptor 7JVR β3-adrenoceptor 7DH5
TM4 135 L 4.49x49 D2 receptor 7JVR apelin receptor 5VBL
TM4 136 V 4.50x50 D2 receptor 7JVR - -
TM4 137 T 4.51x51 D2 receptor 7JVR 5-ht1E receptor 7E33
TM4 138 S 4.52x52 D2 receptor 7JVR EP4 receptor 7D7M
TM4 139 V 4.53x53 D2 receptor 7JVR EP3 receptor 6M9T
TM4 140 F 4.54x54 D2 receptor 7JVR D2 receptor 7JVR
TM4 141 L 4.55x55 D2 receptor 7JVR H1 receptor 7DFL
TM4 142 F 4.56x56 D2 receptor 7JVR EP4 receptor 7D7M
TM4 143 L 4.57x57 MC4 receptor 6W25 MT2 receptor 6ME7
TM4 144 N 4.58x58 MC4 receptor 6W25 - -
TM4 145 I 4.59x59 MC4 receptor 6W25 5-HT2B receptor 5TUD
TM4 146 A 4.60x60 D2 receptor 7JVR κ receptor 6B73
TM4 147 L 4.61x61 D2 receptor 7JVR D2 receptor 7JVR
TM4 148 I 4.62x62 D2 receptor 7JVR MC4 receptor 7AUE
TM4 149 N 4.63x63 D2 receptor 7JVR - -
TM4 150 I 4.64x64 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM4 151 H 4.65x65 5-HT2C receptor 6BQH - -
TM4 152 I 4.66x66 5-HT2C receptor 6BQH - -
TM4 153 N 4.67x67 5-HT2C receptor 6BQH - -
ECL2 154 A - - - - -
ECL2 155 S - - - - -
ECL2 156 I - - - - -
ECL2 157 N - - - - -
ECL2 158 G - - - - -
ECL2 159 Y - - - - -
ECL2 160 R - - - - -
ECL2 161 R - - - - -
ECL2 162 N - - - - -
ECL2 163 K - - - - -
ECL2 164 T - - - - -
ECL2 165 C - - - - -
ECL2 166 S - - - - -
ECL2 167 S - - - - -
ECL2 168 D - - - - -
ECL2 169 S - - - - -
ECL2 170 S - - - - -
ECL2 171 N - - - - -
TM5 172 F 5.32x32 apelin receptor 5VBL - -
TM5 173 T 5.33x33 apelin receptor 5VBL NTS1 receptor 6OSA
TM5 174 R 5.34x34 apelin receptor 5VBL CCR6 6WWZ
TM5 175 F 5.35x35 apelin receptor 5VBL - -
TM5 176 S 5.36x36 D2 receptor 7JVR A1 receptor 6D9H
TM5 177 S 5.37x37 D2 receptor 7JVR MC4 receptor 6W25
TM5 178 L 5.38x38 D2 receptor 7JVR CXCR2 6LFO
TM5 179 I 5.39x39 D2 receptor 7JVR M1 receptor 6OIJ
TM5 180 V 5.40x40 D2 receptor 7JVR D2 receptor 7JVR
TM5 181 L 5.41x41 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM5 182 T 5.42x42 D2 receptor 7JVR AT1 receptor 6DO1
TM5 183 S 5.43x43 D2 receptor 7JVR D2 receptor 7JVR
TM5 184 T 5.44x44 D2 receptor 7JVR 5-ht1E receptor 7E33
TM5 185 V 5.45x45 D2 receptor 7JVR D3 receptor 7CMV
TM5 186 F 5.46x46 ghrelin receptor 6KO5 ghrelin receptor 6KO5
TM5 187 I 5.47x47 ghrelin receptor 6KO5 CB2 receptor 6PT0
TM5 188 F 5.48x48 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM5 189 I 5.49x49 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM5 190 P 5.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM5 191 F 5.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM5 192 T 5.52x52 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM5 193 L 5.53x53 D2 receptor 7JVR MC4 receptor 7AUE
TM5 194 S 5.54x54 D2 receptor 7JVR PAR1 3VW7
TM5 195 L 5.55x55 D2 receptor 7JVR D2 receptor 7JVR
TM5 196 A 5.56x56 D2 receptor 7JVR 5-HT1B receptor 4IAQ
TM5 197 M 5.57x57 D2 receptor 7JVR - -
TM5 198 F 5.58x58 D2 receptor 7JVR FFA1 receptor 5TZY
TM5 199 L 5.59x59 D2 receptor 7JVR β1-adrenoceptor 7BU7
TM5 200 L 5.60x60 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM5 201 L 5.61x61 D2 receptor 7JVR Rhodopsin 4X1H
TM5 202 I 5.62x62 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM5 203 F 5.63x63 D2 receptor 7JVR OT receptor 6TPK
TM5 204 S 5.64x64 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM5 205 M 5.65x65 D2 receptor 7JVR ETB receptor 5X93
TM5 206 W 5.66x66 D2 receptor 7JVR OT receptor 6TPK
TM5 207 K 5.67x67 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM5 208 H 5.68x68 D2 receptor 7JVR MC4 receptor 7AUE
TM5 209 R 5.69x69 D2 receptor 7JVR D2 receptor 7JVR
TM5 210 K 5.70x70 D2 receptor 7JVR D2 receptor 7JVR
TM5 211 K 5.71x71 D2 receptor 7JVR D3 receptor 7CMV
TM5 212 M 5.72x72 D2 receptor 7JVR A2A receptor 4UHR
ICL3 213 Q - - - - -
ICL3 214 H - - - - -
ICL3 215 T - - - - -
ICL3 216 V - - - - -
ICL3 217 K - - - - -
ICL3 218 I - - - - -
ICL3 219 S - - - - -
ICL3 220 G - - - - -
TM6 221 D 6.29x29 D2 receptor 7JVR TP receptor 6IIV
TM6 222 A 6.30x30 D2 receptor 7JVR NK1 receptor 6HLP
TM6 223 S 6.31x31 D2 receptor 7JVR FPR2/ALX 6OMM
TM6 224 T 6.32x32 D2 receptor 7JVR - -
TM6 225 K 6.33x33 D2 receptor 7JVR CysLT2 receptor 6RZ6
TM6 226 A 6.34x34 D2 receptor 7JVR MC4 receptor 7AUE
TM6 227 H 6.35x35 D2 receptor 7JVR - -
TM6 228 R 6.36x36 D2 receptor 7JVR - -
TM6 229 G 6.37x37 D2 receptor 7JVR - -
TM6 230 V 6.38x38 D2 receptor 7JVR CB1 receptor 6N4B
TM6 231 K 6.39x39 D2 receptor 7JVR - -
TM6 232 S 6.40x40 D2 receptor 7JVR - -
TM6 233 V 6.41x41 D2 receptor 7JVR κ receptor 6B73
TM6 234 I 6.42x42 D2 receptor 7JVR CCR5 7O7F
TM6 235 T 6.43x43 D2 receptor 7JVR β3-adrenoceptor 7DH5
TM6 236 F 6.44x44 D2 receptor 7JVR D2 receptor 7JVR
TM6 237 F 6.45x45 D2 receptor 7JVR CCR5 7O7F
TM6 238 L 6.46x46 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM6 239 L 6.47x47 D2 receptor 7JVR GPR52 6LI3
TM6 240 Y 6.48x48 D2 receptor 7JVR OX2 receptor 7L1V
TM6 241 A 6.49x49 D2 receptor 7JVR MC4 receptor 7AUE
TM6 242 I 6.50x50 D2 receptor 7JVR - -
TM6 243 F 6.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM6 244 S 6.52x52 D2 receptor 7JVR OX2 receptor 7L1V
TM6 245 L 6.53x53 D2 receptor 7JVR D3 receptor 7CMV
TM6 246 S 6.54x54 D2 receptor 7JVR α2B-adrenoceptor 6K42
TM6 247 F 6.55x55 D2 receptor 7JVR H1 receptor 7DFL
TM6 248 F 6.56x56 D2 receptor 7JVR AT1 receptor 6DO1
TM6 249 I 6.57x57 D2 receptor 7JVR A1 receptor 6D9H
TM6 250 S 6.58x58 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM6 251 V 6.59x59 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM6 252 W 6.60x60 D2 receptor 7JVR V2 receptor 7KH0
TM6 253 T 6.61x61 D2 receptor 7JVR CysLT2 receptor 6RZ6
ECL3 254 S - D2 receptor 7JVR - -
ECL3 255 E - D2 receptor 7JVR - -
ECL3 256 R - D2 receptor 7JVR - -
ECL3 257 L - D2 receptor 7JVR - -
TM7 258 E 7.31x31 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM7 259 E 7.32x32 D2 receptor 7JVR D3 receptor 7CMV
TM7 260 N 7.33x33 D2 receptor 7JVR - -
TM7 261 L 7.34x34 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM7 262 I 7.35x35 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM7 263 I 7.36x36 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM7 264 L 7.37x37 D2 receptor 7JVR β3-adrenoceptor 7DH5
TM7 265 S 7.38x38 D2 receptor 7JVR CB2 receptor 6PT0
TM7 266 Q 7.39x39 D2 receptor 7JVR - -
TM7 267 V 7.40x40 D2 receptor 7JVR PAR1 3VW7
TM7 268 M 7.41x41 D2 receptor 7JVR - -
TM7 269 G 7.42x42 D2 receptor 7JVR - -
TM7 270 M 7.43x43 D2 receptor 7JVR - -
TM7 271 A 7.44x44 - - - -
TM7 272 Y 7.45x45 D2 receptor 7JVR - -
TM7 273 P 7.46x46 D2 receptor 7JVR EP4 receptor 7D7M
TM7 274 S 7.47x47 D2 receptor 7JVR κ receptor 6B73
TM7 275 C 7.48x48 D2 receptor 7JVR OT receptor 6TPK
TM7 276 H 7.49x49 D2 receptor 7JVR - -
TM7 277 S 7.50x50 D2 receptor 7JVR - -
TM7 278 C 7.51x51 D2 receptor 7JVR - -
TM7 279 V 7.52x52 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM7 280 L 7.53x53 D2 receptor 7JVR ETB receptor 5X93
TM7 281 I 7.54x54 D2 receptor 7JVR Rhodopsin 4X1H
TM7 282 L 7.55x55 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM7 283 G 7.56x56 D2 receptor 7JVR GPBA receptor 7CFN
H8 284 N 8.47x47 D2 receptor 7JVR D2 receptor 7JVR
H8 285 K 8.48x48 D2 receptor 7JVR 5-HT2C receptor 6BQG
H8 286 K 8.49x49 D2 receptor 7JVR CCR5 7O7F
H8 287 L 8.50x50 D2 receptor 7JVR MC4 receptor 7AUE
H8 288 R 8.51x51 D2 receptor 7JVR D2 receptor 7JVR
H8 289 Q 8.52x52 D2 receptor 7JVR NTS1 receptor 4XES
H8 290 A 8.53x53 D2 receptor 7JVR D2 receptor 7JVR
H8 291 S 8.54x54 D2 receptor 7JVR - -
H8 292 L 8.55x55 D2 receptor 7JVR D2 receptor 7JVR
H8 293 S 8.56x56 D2 receptor 7JVR NTS1 receptor 4XES
H8 294 V 8.57x57 D2 receptor 7JVR AT2 receptor 5UNG
H8 295 L 8.58x58 D2 receptor 7JVR D2 receptor 7JVR
H8 296 L 8.59x59 apelin receptor 5VBL apelin receptor 5VBL
H8 297 W 8.60x60 apelin receptor 5VBL OX2 receptor 6TPN
C-term 298 L - - - - -
C-term 299 R - - - - -
C-term 300 Y - - - - -
C-term 301 M - - - - -
C-term 302 F - - - - -