TAS2R50 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

TAS2R50

SPECIES

Homo sapiens

STATE

Active

VERSION

2021-04-08

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

D2 receptor (sequence similarity: 23%) PDB: 7JVR
Align

TEMPLATES

7JVR (D2 receptor)
6M9T (EP3 receptor)
4XES (NTS1 receptor)
5VBL (apelin receptor)
3RZE (H1 receptor)
6W25 (MC4 receptor)
6A94 (5-HT2A receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.9 6.4 16.7
Side-chains 13.0 54.5 32.4

Number of backbone templates: 7
Number of rotamer templates: 53

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - - -
N-term 2 I - - - - -
N-term 3 T - - - - -
N-term 4 F - - - - -
N-term 5 L - - - - -
TM1 6 Y 1.32x32 D2 receptor 7JVR D2 receptor 7JVR
TM1 7 I 1.33x33 D2 receptor 7JVR D1 receptor 7JVQ
TM1 8 F 1.34x34 D2 receptor 7JVR M2 receptor 4MQT
TM1 9 F 1.35x35 D2 receptor 7JVR CysLT2 receptor 6RZ6
TM1 10 S 1.36x36 D2 receptor 7JVR CysLT1 receptor 6RZ4
TM1 11 I 1.37x37 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM1 12 L 1.38x38 D2 receptor 7JVR D2 receptor 7JVR
TM1 13 I 1.39x39 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM1 14 M 1.40x40 D2 receptor 7JVR apelin receptor 5VBL
TM1 15 V 1.41x41 D2 receptor 7JVR κ receptor 6B73
TM1 16 L 1.42x42 D2 receptor 7JVR D2 receptor 7JVR
TM1 17 F 1.43x43 D2 receptor 7JVR AT1 receptor 6DO1
TM1 18 V 1.44x44 D2 receptor 7JVR AT1 receptor 6DO1
TM1 19 L 1.45x45 D2 receptor 7JVR CB2 receptor 6PT0
TM1 20 G 1.46x46 D2 receptor 7JVR AT1 receptor 6DO1
TM1 21 N 1.47x47 D2 receptor 7JVR - -
TM1 22 F 1.48x48 D2 receptor 7JVR D2 receptor 7JVR
TM1 23 A 1.49x49 D2 receptor 7JVR GPBA receptor 7CFN
TM1 24 N 1.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM1 25 G 1.51x51 D2 receptor 7JVR D3 receptor 7CMV
TM1 26 F 1.52x52 D2 receptor 7JVR 5-HT1B receptor 6G79
TM1 27 I 1.53x53 D2 receptor 7JVR DP2 receptor 6D27
TM1 28 A 1.54x54 D2 receptor 7JVR NTS1 receptor 6UP7
TM1 29 L 1.55x55 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM1 30 V 1.56x56 D2 receptor 7JVR AT1 receptor 6DO1
TM1 31 N 1.57x57 D2 receptor 7JVR - -
TM1 32 F 1.58x58 D2 receptor 7JVR apelin receptor 5VBL
TM1 33 I 1.59x59 D2 receptor 7JVR - -
TM1 34 D 1.60x60 D2 receptor 7JVR - -
TM1 35 W 1.61x61 EP3 receptor 6M9T - -
TM1 36 V 1.62x62 EP3 receptor 6M9T - -
ICL1 37 K 12.48x48 D2 receptor 7JVR D2 receptor 7JVR
ICL1 38 R 12.49x49 D2 receptor 7JVR β2-adrenoceptor 4LDE
ICL1 39 K 12.50x50 D2 receptor 7JVR - -
ICL1 40 K 12.51x51 D2 receptor 7JVR M1 receptor 6OIJ
TM2 41 I 2.36x36 NTS1 receptor 4XES - -
TM2 42 S 2.37x37 D2 receptor 7JVR CCR6 6WWZ
TM2 43 S 2.38x38 D2 receptor 7JVR EP3 receptor 6AK3
TM2 44 A 2.39x39 D2 receptor 7JVR AT1 receptor 6DO1
TM2 45 D 2.40x40 D2 receptor 7JVR CCR6 6WWZ
TM2 46 Q 2.41x41 D2 receptor 7JVR - -
TM2 47 I 2.42x42 D2 receptor 7JVR Rhodopsin 5W0P
TM2 48 L 2.43x43 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM2 49 T 2.44x44 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM2 50 A 2.45x45 D2 receptor 7JVR - -
TM2 51 L 2.46x46 D2 receptor 7JVR D2 receptor 7JVR
TM2 52 A 2.47x47 D2 receptor 7JVR D2 receptor 7JVR
TM2 53 V 2.48x48 D2 receptor 7JVR D2 receptor 7JVR
TM2 54 S 2.49x49 D2 receptor 7JVR D1 receptor 7JVQ
TM2 55 R 2.50x50 D2 receptor 7JVR - -
TM2 56 I 2.51x51 D2 receptor 7JVR A2A receptor 4UHR
TM2 57 G 2.52x52 D2 receptor 7JVR Rhodopsin 6I9K
TM2 58 L 2.53x53 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM2 59 L 2.54x54 D2 receptor 7JVR AT1 receptor 6DO1
TM2 60 W 2.55x55 apelin receptor 5VBL - -
TM2 61 A 2.56x56 apelin receptor 5VBL A2A receptor 4UHR
TM2 62 L 2.57x57 D2 receptor 7JVR AT1 receptor 6DO1
TM2 63 L 2.58x58 D2 receptor 7JVR GPR52 6LI3
TM2 64 L 2.59x59 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM2 65 N 2.60x60 D2 receptor 7JVR H1 receptor 7DFL
TM2 66 W 2.61x61 D2 receptor 7JVR - -
TM2 67 Y 2.62x62 D2 receptor 7JVR D2 receptor 7JVR
TM2 68 L 2.63x63 D2 receptor 7JVR D2 receptor 7JVR
TM2 69 T 2.64x64 D2 receptor 7JVR AT1 receptor 6DO1
TM2 70 V 2.65x65 D2 receptor 7JVR D2 receptor 7JVR
TM2 71 L 2.66x66 D2 receptor 7JVR MC4 receptor 6W25
ECL1 72 N - - - - -
ECL1 73 P - H1 receptor 3RZE - -
ECL1 74 A - H1 receptor 3RZE - -
ECL1 75 F - H1 receptor 3RZE - -
ECL1 76 Y - - - - -
TM3 77 S 3.21x21 D2 receptor 7JVR D2 receptor 7JVR
TM3 78 V 3.22x22 D2 receptor 7JVR MC4 receptor 6W25
TM3 79 E 3.23x23 D2 receptor 7JVR ETB receptor 5X93
TM3 80 L 3.24x24 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM3 81 R 3.25x25 D2 receptor 7JVR - -
TM3 82 I 3.26x26 D2 receptor 7JVR succinate receptor 6RNK
TM3 83 T 3.27x27 D2 receptor 7JVR NOP receptor 5DHG
TM3 84 S 3.28x28 D2 receptor 7JVR EP4 receptor 7D7M
TM3 85 Y 3.29x29 D2 receptor 7JVR NTS1 receptor 4XES
TM3 86 N 3.30x30 D2 receptor 7JVR - -
TM3 87 A 3.31x31 D2 receptor 7JVR GPBA receptor 7CFN
TM3 88 W 3.32x32 D2 receptor 7JVR - -
TM3 89 V 3.33x33 D2 receptor 7JVR D2 receptor 7JVR
TM3 90 V 3.34x34 D2 receptor 7JVR H1 receptor 7DFL
TM3 91 T 3.35x35 D2 receptor 7JVR CB2 receptor 6PT0
TM3 92 N 3.36x36 D2 receptor 7JVR - -
TM3 93 H 3.37x37 D2 receptor 7JVR - -
TM3 94 F 3.38x38 D2 receptor 7JVR - -
TM3 95 S 3.39x39 D2 receptor 7JVR D2 receptor 7JVR
TM3 96 M 3.40x40 D2 receptor 7JVR CCR6 6WWZ
TM3 97 W 3.41x41 D2 receptor 7JVR β2-adrenoceptor 7DHI
TM3 98 L 3.42x42 D2 receptor 7JVR AT1 receptor 6DO1
TM3 99 A 3.43x43 D2 receptor 7JVR EP3 receptor 6AK3
TM3 100 A 3.44x44 D2 receptor 7JVR CXCR2 6LFO
TM3 101 N 3.45x45 D2 receptor 7JVR - -
TM3 102 L 3.46x46 D2 receptor 7JVR H1 receptor 7DFL
TM3 103 S 3.47x47 D2 receptor 7JVR D2 receptor 7JVR
TM3 104 I 3.48x48 D2 receptor 7JVR D2 receptor 7JVR
TM3 105 F 3.49x49 D2 receptor 7JVR CysLT1 receptor 6RZ4
TM3 106 Y 3.50x50 D2 receptor 7JVR - -
TM3 107 L 3.51x51 D2 receptor 7JVR - -
TM3 108 L 3.52x52 D2 receptor 7JVR AT1 receptor 6DO1
TM3 109 K 3.53x53 D2 receptor 7JVR P2Y12 receptor 4NTJ
TM3 110 I 3.54x54 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM3 111 A 3.55x55 D2 receptor 7JVR D2 receptor 7JVR
TM3 112 N 3.56x56 D2 receptor 7JVR 5-HT2C receptor 6BQG
ICL2 113 F - - - - -
ICL2 114 S - - - - -
ICL2 115 N 34.50x50 D2 receptor 7JVR - -
ICL2 116 L 34.51x51 D2 receptor 7JVR M2 receptor 4MQT
ICL2 117 L 34.52x52 D2 receptor 7JVR D2 receptor 7JVR
ICL2 118 F 34.53x53 D2 receptor 7JVR - -
ICL2 119 L 34.54x54 D2 receptor 7JVR κ receptor 6B73
ICL2 120 H 34.55x55 - - - -
ICL2 121 L 34.56x56 - - - -
ICL2 122 K 34.57x57 - - - -
TM4 123 R 4.38x38 D2 receptor 7JVR CCR9 5LWE
TM4 124 R 4.39x39 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM4 125 V 4.40x40 D2 receptor 7JVR apelin receptor 5VBL
TM4 126 R 4.41x41 D2 receptor 7JVR D2 receptor 7JVR
TM4 127 S 4.42x42 D2 receptor 7JVR CCR6 6WWZ
TM4 128 V 4.43x43 D2 receptor 7JVR CB1 receptor 6N4B
TM4 129 I 4.44x44 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM4 130 L 4.45x45 D2 receptor 7JVR D1 receptor 7JVQ
TM4 131 V 4.46x46 D2 receptor 7JVR Rhodopsin 5W0P
TM4 132 I 4.47x47 D2 receptor 7JVR AT1 receptor 6DO1
TM4 133 L 4.48x48 D2 receptor 7JVR CB1 receptor 6N4B
TM4 134 L 4.49x49 D2 receptor 7JVR apelin receptor 5VBL
TM4 135 G 4.50x50 D2 receptor 7JVR - -
TM4 136 T 4.51x51 D2 receptor 7JVR CB1 receptor 5XRA
TM4 137 L 4.52x52 D2 receptor 7JVR D2 receptor 7JVR
TM4 138 I 4.53x53 D2 receptor 7JVR CysLT2 receptor 6RZ6
TM4 139 F 4.54x54 D2 receptor 7JVR D2 receptor 7JVR
TM4 140 L 4.55x55 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM4 141 V 4.56x56 D2 receptor 7JVR D3 receptor 7CMV
TM4 142 C 4.57x57 MC4 receptor 6W25 EP4 receptor 7D7M
TM4 143 H 4.58x58 MC4 receptor 6W25 - -
TM4 144 L 4.59x59 MC4 receptor 6W25 MC4 receptor 6W25
TM4 145 L 4.60x60 D2 receptor 7JVR - -
TM4 146 V 4.61x61 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM4 147 A 4.62x62 D2 receptor 7JVR Rhodopsin 5W0P
TM4 148 N 4.63x63 D2 receptor 7JVR - -
ECL2 149 M - - - - -
ECL2 150 D - - - - -
ECL2 151 E - - - - -
ECL2 152 S - - - - -
ECL2 153 M - - - - -
ECL2 154 W - - - - -
ECL2 155 A - - - - -
ECL2 156 E - - - - -
ECL2 157 E - - - - -
ECL2 158 Y - - - - -
ECL2 159 E - - - - -
ECL2 160 G - - - - -
ECL2 161 N - - - - -
ECL2 162 M - - - - -
ECL2 163 T - - - - -
ECL2 164 G - - - - -
ECL2 165 K - - - - -
ECL2 166 M - - - - -
ECL2 167 K - - - - -
ECL2 168 L - - - - -
TM5 169 R 5.32x32 apelin receptor 5VBL - -
TM5 170 N 5.33x33 apelin receptor 5VBL DP2 receptor 6D27
TM5 171 T 5.34x34 apelin receptor 5VBL EP4 receptor 7D7M
TM5 172 V 5.35x35 apelin receptor 5VBL - -
TM5 173 H 5.36x36 D2 receptor 7JVR 5-HT1B receptor 6G79
TM5 174 L 5.37x37 D2 receptor 7JVR κ receptor 6B73
TM5 175 S 5.38x38 D2 receptor 7JVR Rhodopsin 5W0P
TM5 176 Y 5.39x39 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM5 177 L 5.40x40 D2 receptor 7JVR CB1 receptor 6N4B
TM5 178 T 5.41x41 D2 receptor 7JVR GPR52 6LI3
TM5 179 V 5.42x42 D2 receptor 7JVR NTS1 receptor 4XES
TM5 180 T 5.43x43 D2 receptor 7JVR H1 receptor 7DFL
TM5 181 T 5.44x44 D2 receptor 7JVR 5-HT1B receptor 6G79
TM5 182 L 5.45x45 D2 receptor 7JVR 5-HT2B receptor 5TUD
TM5 183 W 5.46x46 MC4 receptor 6W25 - -
TM5 184 S 5.47x47 MC4 receptor 6W25 EP4 receptor 7D7M
TM5 185 F 5.48x48 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM5 186 I 5.49x49 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM5 187 P 5.50x50 D2 receptor 7JVR D2 receptor 7JVR
TM5 188 F 5.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM5 189 T 5.52x52 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM5 190 L 5.53x53 D2 receptor 7JVR H1 receptor 7DFL
TM5 191 S 5.54x54 D2 receptor 7JVR PAR1 3VW7
TM5 192 L 5.55x55 D2 receptor 7JVR D2 receptor 7JVR
TM5 193 I 5.56x56 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM5 194 S 5.57x57 D2 receptor 7JVR AT1 receptor 6DO1
TM5 195 F 5.58x58 D2 receptor 7JVR FFA1 receptor 5TZY
TM5 196 L 5.59x59 D2 receptor 7JVR A1 receptor 6D9H
TM5 197 M 5.60x60 D2 receptor 7JVR CysLT1 receptor 6RZ4
TM5 198 L 5.61x61 D2 receptor 7JVR Rhodopsin 5W0P
TM5 199 I 5.62x62 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM5 200 C 5.63x63 D2 receptor 7JVR ETB receptor 5X93
TM5 201 S 5.64x64 D2 receptor 7JVR 5-HT2A receptor 6WHA
TM5 202 L 5.65x65 D2 receptor 7JVR D2 receptor 7JVR
TM5 203 C 5.66x66 D2 receptor 7JVR GPR52 6LI3
TM5 204 K 5.67x67 D2 receptor 7JVR AT1 receptor 6OS2
TM5 205 H 5.68x68 D2 receptor 7JVR CB1 receptor 6N4B
TM5 206 L 5.69x69 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM5 207 K 5.70x70 D2 receptor 7JVR D2 receptor 7JVR
TM5 208 K 5.71x71 D2 receptor 7JVR D3 receptor 7CMV
TM5 209 M 5.72x72 D2 receptor 7JVR CB1 receptor 6N4B
ICL3 210 Q - - - - -
ICL3 211 L - - - - -
ICL3 212 H - - - - -
ICL3 213 G - - - - -
ICL3 214 E - - - - -
ICL3 215 G - - - - -
ICL3 216 S - - - - -
ICL3 217 Q - - - - -
ICL3 218 D - - - - -
TM6 219 L 6.29x29 D2 receptor 7JVR CB2 receptor 6PT0
TM6 220 S 6.30x30 D2 receptor 7JVR CysLT2 receptor 6RZ6
TM6 221 T 6.31x31 D2 receptor 7JVR D1 receptor 7JVQ
TM6 222 K 6.32x32 D2 receptor 7JVR D2 receptor 7JVR
TM6 223 V 6.33x33 D2 receptor 7JVR M2 receptor 4MQT
TM6 224 H 6.34x34 D2 receptor 7JVR - -
TM6 225 I 6.35x35 D2 receptor 7JVR EP4 receptor 7D7M
TM6 226 K 6.36x36 D2 receptor 7JVR PAR2 5NDD
TM6 227 A 6.37x37 D2 receptor 7JVR NTS1 receptor 4GRV
TM6 228 L 6.38x38 D2 receptor 7JVR M2 receptor 4MQT
TM6 229 Q 6.39x39 D2 receptor 7JVR - -
TM6 230 T 6.40x40 D2 receptor 7JVR EP4 receptor 7D7M
TM6 231 L 6.41x41 D2 receptor 7JVR D2 receptor 7JVR
TM6 232 I 6.42x42 D2 receptor 7JVR Rhodopsin 5W0P
TM6 233 S 6.43x43 D2 receptor 7JVR FPR2/ALX 6OMM
TM6 234 F 6.44x44 D2 receptor 7JVR D2 receptor 7JVR
TM6 235 L 6.45x45 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM6 236 L 6.46x46 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM6 237 L 6.47x47 D2 receptor 7JVR GPR52 6LI3
TM6 238 C 6.48x48 D2 receptor 7JVR - -
TM6 239 A 6.49x49 D2 receptor 7JVR M2 receptor 4MQT
TM6 240 I 6.50x50 D2 receptor 7JVR - -
TM6 241 F 6.51x51 D2 receptor 7JVR D2 receptor 7JVR
TM6 242 F 6.52x52 D2 receptor 7JVR D2 receptor 7JVR
TM6 243 L 6.53x53 D2 receptor 7JVR D3 receptor 7CMV
TM6 244 F 6.54x54 D2 receptor 7JVR H1 receptor 7DFL
TM6 245 L 6.55x55 D2 receptor 7JVR CCR6 6WWZ
TM6 246 I 6.56x56 D2 receptor 7JVR D2 receptor 7JVR
TM6 247 V 6.57x57 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM6 248 S 6.58x58 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM6 249 V 6.59x59 D2 receptor 7JVR 5-HT2C receptor 6BQG
TM6 250 W 6.60x60 D2 receptor 7JVR Y1 receptor 5ZBH
TM6 251 S 6.61x61 D2 receptor 7JVR ghrelin receptor 6KO5
ECL3 252 P - - - - -
ECL3 253 R - - - - -
ECL3 254 R - - - - -
ECL3 255 L - - - - -
ECL3 256 R - - - - -
TM7 257 N 7.31x31 D2 receptor 7JVR M2 receptor 4MQT
TM7 258 D 7.32x32 D2 receptor 7JVR PAF receptor 5ZKQ
TM7 259 P 7.33x33 D2 receptor 7JVR EP4 receptor 7D7M
TM7 260 V 7.34x34 D2 receptor 7JVR FPR2/ALX 6OMM
TM7 261 V 7.35x35 D2 receptor 7JVR CysLT2 receptor 6RZ6
TM7 262 M 7.36x36 D2 receptor 7JVR - -
TM7 263 V 7.37x37 D2 receptor 7JVR D4 receptor 5WIV
TM7 264 S 7.38x38 D2 receptor 7JVR CB2 receptor 6PT0
TM7 265 K 7.39x39 D2 receptor 7JVR - -
TM7 266 A 7.40x40 D2 receptor 7JVR - -
TM7 267 V 7.41x41 D2 receptor 7JVR NTS1 receptor 7L0P
TM7 268 G 7.42x42 D2 receptor 7JVR - -
TM7 269 N 7.43x43 D2 receptor 7JVR - -
TM7 270 I 7.44x44 - - - -
TM7 271 Y 7.45x45 D2 receptor 7JVR - -
TM7 272 L 7.46x46 D2 receptor 7JVR - -
TM7 273 A 7.47x47 D2 receptor 7JVR D2 receptor 7JVR
TM7 274 F 7.48x48 D2 receptor 7JVR β2-adrenoceptor 3SN6
TM7 275 D 7.49x49 D2 receptor 7JVR EP4 receptor 7D7M
TM7 276 S 7.50x50 D2 receptor 7JVR - -
TM7 277 F 7.51x51 D2 receptor 7JVR A2A receptor 4UHR
TM7 278 I 7.52x52 D2 receptor 7JVR D2 receptor 7JVR
TM7 279 L 7.53x53 D2 receptor 7JVR ETB receptor 5X93
TM7 280 I 7.54x54 D2 receptor 7JVR Rhodopsin 5W0P
TM7 281 W 7.55x55 D2 receptor 7JVR Y2 receptor 7DDZ
TM7 282 R 7.56x56 D2 receptor 7JVR CB1 receptor 6N4B
H8 283 T 8.47x47 D2 receptor 7JVR - -
H8 284 K 8.48x48 D2 receptor 7JVR 5-HT2C receptor 6BQG
H8 285 K 8.49x49 D2 receptor 7JVR A1 receptor 6D9H
H8 286 L 8.50x50 D2 receptor 7JVR CB1 receptor 5XRA
H8 287 K 8.51x51 D2 receptor 7JVR H1 receptor 7DFL
H8 288 H 8.52x52 D2 receptor 7JVR CB1 receptor 6N4B
H8 289 T 8.53x53 D2 receptor 7JVR H1 receptor 7DFL
H8 290 F 8.54x54 D2 receptor 7JVR D2 receptor 7JVR
H8 291 L 8.55x55 D2 receptor 7JVR D2 receptor 7JVR
H8 292 L 8.56x56 D2 receptor 7JVR M1 receptor 6OIJ
H8 293 I 8.57x57 D2 receptor 7JVR D2 receptor 7JVR
H8 294 L 8.58x58 D2 receptor 7JVR D2 receptor 7JVR
H8 295 C 8.59x59 5-HT2A receptor 6A94 β2-adrenoceptor 3SN6
H8 296 Q 8.60x60 5-HT2A receptor 6A94 succinate receptor 6IBB
C-term 297 I - - - - -
C-term 298 R - - - - -
C-term 299 C - - - - -