TAS2R1 homology model

PROTEIN CLASS

Class T (Taste 2)

RECEPTOR

TAS2R1

SPECIES

Homo sapiens

STATE

Active

VERSION

2022-06-19

MODEL

PDB file contains GPCRdb generic numbers in the B-factor field of CA atoms

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MAIN TEMPLATE

MC4 receptor (sequence similarity: 24%) PDB: 7F54
Align

TEMPLATES

6ME2 (MT1 receptor)
7F54 (MC4 receptor)
6W25 (MC4 receptor)
7KH0 (V2 receptor)
5ZKQ (PAF receptor)
5X93 (ETB receptor)
None
Main template (%) Additional templates (%) No template - freely modelled (%)
Backbone 76.3 7.0 16.7
Side-chains 9.4 52.5 38.1

Number of backbone templates: 6
Number of rotamer templates: 54

Segment Seq.num. AA GPCRdb# Backbone PDB Rotamer PDB
N-term 1 M - - - - -
N-term 2 L - - - - -
N-term 3 E - - - - -
N-term 4 S - - - - -
N-term 5 H - - - - -
TM1 6 L 1.32x32 MT1 receptor 6ME2 ghrelin receptor 7F83
TM1 7 I 1.33x33 MT1 receptor 6ME2 CXCR4 3ODU
TM1 8 I 1.34x34 MT1 receptor 6ME2 ETB receptor 5X93
TM1 9 Y 1.35x35 MC4 receptor 7F54 D3 receptor 3PBL
TM1 10 F 1.36x36 MC4 receptor 7F54 FFA1 receptor 5TZY
TM1 11 L 1.37x37 MC4 receptor 7F54 5-HT2C receptor 6BQH
TM1 12 L 1.38x38 MC4 receptor 7F54 CB1 receptor 5TGZ
TM1 13 A 1.39x39 MC4 receptor 7F54 M2 receptor 5YC8
TM1 14 V 1.40x40 MC4 receptor 7F54 MC4 receptor 7F54
TM1 15 I 1.41x41 MC4 receptor 7F54 CXCR4 3ODU
TM1 16 Q 1.42x42 MC4 receptor 7F54 - -
TM1 17 F 1.43x43 MC4 receptor 7F54 CXCR4 3ODU
TM1 18 L 1.44x44 MC4 receptor 7F54 CXCR4 3ODU
TM1 19 L 1.45x45 MC4 receptor 7F54 ETB receptor 5X93
TM1 20 G 1.46x46 MC4 receptor 7F54 CXCR4 3ODU
TM1 21 I 1.47x47 MC4 receptor 7F54 MT1 receptor 6ME2
TM1 22 F 1.48x48 MC4 receptor 7F54 D2 receptor 6LUQ
TM1 23 T 1.49x49 MC4 receptor 7F54 LPA6 receptor 5XSZ
TM1 24 N 1.50x50 MC4 receptor 7F54 MC4 receptor 7F54
TM1 25 G 1.51x51 MC4 receptor 7F54 CXCR4 3ODU
TM1 26 I 1.52x52 MC4 receptor 7F54 - -
TM1 27 I 1.53x53 MC4 receptor 7F54 DP2 receptor 7M8W
TM1 28 V 1.54x54 MC4 receptor 7F54 AT1 receptor 4ZUD
TM1 29 V 1.55x55 MC4 receptor 7F54 MC4 receptor 7F54
TM1 30 V 1.56x56 MC4 receptor 7F54 CXCR4 3ODU
TM1 31 N 1.57x57 MC4 receptor 7F54 - -
TM1 32 G 1.58x58 MC4 receptor 7F54 CXCR4 3ODU
TM1 33 I 1.59x59 MC4 receptor 7F54 - -
TM1 34 D 1.60x60 MC4 receptor 7F54 - -
TM1 35 L 1.61x61 V2 receptor 7KH0 - -
TM1 36 I 1.62x62 V2 receptor 7KH0 - -
ICL1 37 K 12.48x48 - - - -
ICL1 38 H 12.49x49 MC4 receptor 6W25 M2 receptor 5YC8
ICL1 39 R 12.50x50 MC4 receptor 6W25 - -
ICL1 40 K 12.51x51 - - - -
TM2 41 M 2.36x36 PAF receptor 5ZKQ - -
TM2 42 A 2.37x37 MC4 receptor 7F54 α2A-adrenoceptor 6KUX
TM2 43 P 2.38x38 MC4 receptor 7F54 MC4 receptor 7F54
TM2 44 L 2.39x39 MC4 receptor 7F54 Rhodopsin 1U19
TM2 45 D 2.40x40 MC4 receptor 7F54 CXCR4 3ODU
TM2 46 L 2.41x41 MC4 receptor 7F54 MT2 receptor 6ME7
TM2 47 L 2.42x42 MC4 receptor 7F54 ETB receptor 5X93
TM2 48 L 2.43x43 MC4 receptor 7F54 MT2 receptor 6ME7
TM2 49 S 2.44x44 MC4 receptor 7F54 ghrelin receptor 7F83
TM2 50 C 2.45x45 MC4 receptor 7F54 - -
TM2 51 L 2.46x46 MC4 receptor 7F54 MC4 receptor 7F54
TM2 52 A 2.47x47 MC4 receptor 7F54 MC4 receptor 7F54
TM2 53 V 2.48x48 MC4 receptor 7F54 MC4 receptor 7F54
TM2 54 S 2.49x49 MC4 receptor 7F54 ghrelin receptor 7F83
TM2 55 R 2.50x50 MC4 receptor 7F54 - -
TM2 56 I 2.51x51 MC4 receptor 7F54 α2A-adrenoceptor 6KUX
TM2 57 F 2.52x52 MC4 receptor 7F54 LPA1 receptor 4Z35
TM2 58 L 2.53x53 MC4 receptor 7F54 CCK1 receptor 7F8Y
TM2 59 Q 2.54x54 MC4 receptor 7F54 - -
TM2 60 L 2.55x55 MC4 receptor 7F54 5-HT2C receptor 6BQH
TM2 61 F 2.56x56 MC4 receptor 7F54 Rhodopsin 6I9K
TM2 62 I 2.57x57 MC4 receptor 7F54 ETB receptor 5X93
TM2 63 F 2.58x58 MC4 receptor 7F54 LPA1 receptor 4Z35
TM2 64 Y 2.59x59 MC4 receptor 7F54 CB1 receptor 5TGZ
TM2 65 V 2.60x60 MC4 receptor 7F54 MT1 receptor 6ME2
TM2 66 N 2.61x61 MC4 receptor 7F54 NK1 receptor 6HLP
TM2 67 V 2.62x62 MC4 receptor 7F54 MT2 receptor 6ME7
TM2 68 I 2.63x63 MC4 receptor 7F54 β1-adrenoceptor 7BVQ
TM2 69 V 2.64x64 MC4 receptor 7F54 β1-adrenoceptor 7BVQ
TM2 70 I 2.65x65 MC4 receptor 7F54 M3 receptor 5ZHP
TM2 71 F 2.66x66 MC4 receptor 7F54 5-HT2B receptor 4NC3
ECL1 72 F - - - - -
ECL1 73 I - - - - -
ECL1 74 E - - - - -
ECL1 75 F - - - - -
ECL1 76 I - - - - -
TM3 77 M 3.24x24 MC4 receptor 7F54 ETB receptor 5X93
TM3 78 C 3.25x25 MC4 receptor 7F54 MT1 receptor 6ME2
TM3 79 S 3.26x26 MC4 receptor 7F54 C5a1 receptor 6C1Q
TM3 80 A 3.27x27 MC4 receptor 7F54 MT2 receptor 6ME7
TM3 81 N 3.28x28 MC4 receptor 7F54 succinate receptor 6RNK
TM3 82 C 3.29x29 MC4 receptor 7F54 - -
TM3 83 A 3.30x30 MC4 receptor 7F54 M2 receptor 5YC8
TM3 84 I 3.31x31 MC4 receptor 7F54 CXCR4 3ODU
TM3 85 L 3.32x32 MC4 receptor 7F54 CysLT1 receptor 6RZ4
TM3 86 L 3.33x33 MC4 receptor 7F54 OT receptor 6TPK
TM3 87 F 3.34x34 MC4 receptor 7F54 AT1 receptor 4ZUD
TM3 88 I 3.35x35 MC4 receptor 7F54 - -
TM3 89 N 3.36x36 MC4 receptor 7F54 - -
TM3 90 E 3.37x37 MC4 receptor 7F54 Rhodopsin 1U19
TM3 91 L 3.38x38 MC4 receptor 7F54 - -
TM3 92 E 3.39x39 MC4 receptor 7F54 - -
TM3 93 L 3.40x40 MC4 receptor 7F54 Rhodopsin 1U19
TM3 94 W 3.41x41 MC4 receptor 7F54 MT1 receptor 6ME2
TM3 95 L 3.42x42 MC4 receptor 7F54 CXCR2 6LFL
TM3 96 A 3.43x43 MC4 receptor 7F54 - -
TM3 97 T 3.44x44 MC4 receptor 7F54 MT1 receptor 6ME2
TM3 98 W 3.45x45 MC4 receptor 7F54 - -
TM3 99 L 3.46x46 MC4 receptor 7F54 ETB receptor 5X93
TM3 100 G 3.47x47 MC4 receptor 7F54 - -
TM3 101 V 3.48x48 MC4 receptor 7F54 MC4 receptor 7F54
TM3 102 F 3.49x49 MC4 receptor 7F54 CysLT1 receptor 6RZ4
TM3 103 Y 3.50x50 MC4 receptor 7F54 - -
TM3 104 C 3.51x51 MC4 receptor 7F54 DP2 receptor 7M8W
TM3 105 A 3.52x52 MC4 receptor 7F54 - -
TM3 106 K 3.53x53 MC4 receptor 7F54 P2Y12 receptor 4NTJ
TM3 107 V 3.54x54 MC4 receptor 7F54 ETB receptor 5X93
TM3 108 A 3.55x55 MC4 receptor 7F54 ETB receptor 5X93
TM3 109 S 3.56x56 MC4 receptor 7F54 ETB receptor 5X93
ICL2 110 V - - - - -
ICL2 111 R - - - - -
ICL2 112 H 34.50x50 MC4 receptor 6W25 - -
ICL2 113 P 34.51x51 MC4 receptor 6W25 CB2 receptor 5ZTY
ICL2 114 L 34.52x52 MC4 receptor 6W25 BLT1 receptor 5X33
ICL2 115 F 34.53x53 MC4 receptor 6W25 - -
ICL2 116 I 34.54x54 MC4 receptor 6W25 - -
ICL2 117 W 34.55x55 MC4 receptor 6W25 - -
ICL2 118 L 34.56x56 MC4 receptor 6W25 LPA6 receptor 5XSZ
ICL2 119 K 34.57x57 - - - -
TM4 120 M 4.38x38 MC4 receptor 7F54 - -
TM4 121 R 4.39x39 MC4 receptor 7F54 5-HT2C receptor 6BQH
TM4 122 I 4.40x40 MC4 receptor 7F54 - -
TM4 123 S 4.41x41 MC4 receptor 7F54 apelin receptor 5VBL
TM4 124 K 4.42x42 MC4 receptor 7F54 - -
TM4 125 L 4.43x43 MC4 receptor 7F54 MT1 receptor 6ME2
TM4 126 V 4.44x44 MC4 receptor 7F54 CXCR4 3ODU
TM4 127 P 4.45x45 MC4 receptor 7F54 - -
TM4 128 W 4.46x46 MC4 receptor 7F54 - -
TM4 129 M 4.47x47 MC4 receptor 7F54 - -
TM4 130 I 4.48x48 MC4 receptor 7F54 5-HT2C receptor 6BQH
TM4 131 L 4.49x49 MC4 receptor 7F54 apelin receptor 5VBL
TM4 132 G 4.50x50 MC4 receptor 7F54 - -
TM4 133 S 4.51x51 MC4 receptor 7F54 - -
TM4 134 L 4.52x52 MC4 receptor 7F54 MT1 receptor 6ME2
TM4 135 L 4.53x53 MC4 receptor 7F54 - -
TM4 136 Y 4.54x54 MC4 receptor 7F54 - -
TM4 137 V 4.55x55 MC4 receptor 7F54 MC4 receptor 7F54
TM4 138 S 4.56x56 MC4 receptor 7F54 MC4 receptor 7F54
TM4 139 M 4.57x57 MC4 receptor 7F54 CCK1 receptor 7F8Y
TM4 140 I 4.58x58 MC4 receptor 7F54 MC4 receptor 7F54
TM4 141 C 4.59x59 MC4 receptor 7F54 D2 receptor 6LUQ
TM4 142 V 4.60x60 MC4 receptor 7F54 μ receptor 4DKL
TM4 143 F 4.61x61 MC4 receptor 7F54 CysLT1 receptor 6RZ4
TM4 144 H 4.62x62 MC4 receptor 7F54 - -
TM4 145 S 4.63x63 MC4 receptor 7F54 - -
TM4 146 K 4.64x64 MC4 receptor 7F54 5-HT2B receptor 5TVN
ECL2 147 Y - - - - -
ECL2 148 A - - - - -
ECL2 149 G - - - - -
ECL2 150 F - - - - -
ECL2 151 M - - - - -
ECL2 152 V - - - - -
ECL2 153 P - - - - -
ECL2 154 Y - - - - -
ECL2 155 F - - - - -
ECL2 156 L - - - - -
ECL2 157 R - - - - -
ECL2 158 K - - - - -
ECL2 159 F - - - - -
ECL2 160 F - - - - -
ECL2 161 S - - - - -
ECL2 162 Q - - - - -
ECL2 163 N - - - - -
ECL2 164 A - - - - -
ECL2 165 T - - - - -
ECL2 166 I - - - - -
ECL2 167 Q - - - - -
TM5 168 K 5.32x32 ETB receptor 5X93 CysLT2 receptor 6RZ6
TM5 169 E 5.33x33 ETB receptor 5X93 BLT1 receptor 7K15
TM5 170 D 5.34x34 ETB receptor 5X93 - -
TM5 171 T 5.35x35 ETB receptor 5X93 NTS1 receptor 4BUO
TM5 172 L 5.36x36 MC4 receptor 7F54 - -
TM5 173 A 5.37x37 MC4 receptor 7F54 M2 receptor 5YC8
TM5 174 I 5.38x38 MC4 receptor 7F54 M1 receptor 6ZFZ
TM5 175 Q 5.39x39 MC4 receptor 7F54 CCR5 4MBS
TM5 176 I 5.40x40 MC4 receptor 7F54 MC4 receptor 7F54
TM5 177 F 5.41x41 MC4 receptor 7F54 CXCR4 3ODU
TM5 178 S 5.42x42 MC4 receptor 7F54 apelin receptor 5VBL
TM5 179 F 5.43x43 MC4 receptor 7F54 OX2 receptor 5WQC
TM5 180 V 5.44x44 MC4 receptor 7F54 MT1 receptor 6ME2
TM5 181 A 5.45x45 MC4 receptor 7F54 - -
TM5 182 E 5.46x46 MC4 receptor 7F54 - -
TM5 183 F 5.47x47 MC4 receptor 7F54 MC4 receptor 7F54
TM5 184 S 5.48x48 MC4 receptor 7F54 CB1 receptor 5TGZ
TM5 185 V 5.49x49 MC4 receptor 7F54 MT1 receptor 6ME2
TM5 186 P 5.50x50 MC4 receptor 7F54 MT1 receptor 6ME2
TM5 187 L 5.51x51 MC4 receptor 7F54 MC4 receptor 7F54
TM5 188 L 5.52x52 MC4 receptor 7F54 CB1 receptor 5TGZ
TM5 189 I 5.53x53 MC4 receptor 7F54 MT1 receptor 6ME2
TM5 190 F 5.54x54 MC4 receptor 7F54 - -
TM5 191 L 5.55x55 MC4 receptor 7F54 CXCR4 3ODU
TM5 192 F 5.56x56 MC4 receptor 7F54 MT1 receptor 6ME2
TM5 193 A 5.57x57 MC4 receptor 7F54 CB1 receptor 5TGZ
TM5 194 V 5.58x58 MC4 receptor 7F54 - -
TM5 195 L 5.59x59 MC4 receptor 7F54 MT1 receptor 6ME2
TM5 196 L 5.60x60 MC4 receptor 7F54 ETB receptor 5X93
TM5 197 L 5.61x61 MC4 receptor 7F54 Rhodopsin 1GZM
TM5 198 I 5.62x62 MC4 receptor 7F54 CXCR4 3ODU
TM5 199 F 5.63x63 MC4 receptor 7F54 Rhodopsin 1GZM
TM5 200 S 5.64x64 MC4 receptor 7F54 5-HT2A receptor 6A94
TM5 201 L 5.65x65 MC4 receptor 7F54 CXCR4 3OE0
TM5 202 G 5.66x66 MC4 receptor 7F54 - -
TM5 203 R 5.67x67 MC4 receptor 7F54 ETB receptor 5X93
TM5 204 H 5.68x68 MC4 receptor 7F54 MC4 receptor 7F54
TM5 205 T 5.69x69 MC4 receptor 7F54 α2A-adrenoceptor 6KUX
TM5 206 R 5.70x70 MC4 receptor 7F54 - -
TM5 207 Q 5.71x71 MC4 receptor 7F54 A2A receptor 3VG9
TM5 208 M 5.72x72 MC4 receptor 7F54 A2A receptor 3VG9
ICL3 209 R - MC4 receptor 7F54 - -
ICL3 210 N - MC4 receptor 7F54 - -
ICL3 211 T - MC4 receptor 7F54 - -
ICL3 212 V - MC4 receptor 7F54 - -
ICL3 213 A - MC4 receptor 7F54 - -
ICL3 214 G - - - - -
ICL3 215 S - - - - -
ICL3 216 R - - - - -
ICL3 217 V - - - - -
TM6 218 P 6.29x29 MC4 receptor 7F54 P2Y1 receptor 4XNW
TM6 219 G 6.30x30 MC4 receptor 7F54 - -
TM6 220 R 6.31x31 MC4 receptor 7F54 CXCR4 3ODU
TM6 221 G 6.32x32 MC4 receptor 7F54 - -
TM6 222 A 6.33x33 MC4 receptor 7F54 CXCR4 3ODU
TM6 223 P 6.34x34 MC4 receptor 7F54 - -
TM6 224 I 6.35x35 MC4 receptor 7F54 MC4 receptor 7F54
TM6 225 S 6.36x36 MC4 receptor 7F54 A2A receptor 5IU4
TM6 226 A 6.37x37 MC4 receptor 7F54 D2 receptor 6LUQ
TM6 227 L 6.38x38 MC4 receptor 7F54 M2 receptor 5YC8
TM6 228 L 6.39x39 MC4 receptor 7F54 CB1 receptor 5TGZ
TM6 229 S 6.40x40 MC4 receptor 7F54 - -
TM6 230 I 6.41x41 MC4 receptor 7F54 MC4 receptor 7F54
TM6 231 L 6.42x42 MC4 receptor 7F54 CXCR4 3ODU
TM6 232 S 6.43x43 MC4 receptor 7F54 C5a1 receptor 6C1Q
TM6 233 F 6.44x44 MC4 receptor 7F54 MC4 receptor 7F54
TM6 234 L 6.45x45 MC4 receptor 7F54 5-HT2C receptor 6BQH
TM6 235 I 6.46x46 MC4 receptor 7F54 MT1 receptor 6ME2
TM6 236 L 6.47x47 MC4 receptor 7F54 succinate receptor 6RNK
TM6 237 Y 6.48x48 MC4 receptor 7F54 OX2 receptor 5WQC
TM6 238 F 6.49x49 MC4 receptor 7F54 α2A-adrenoceptor 6KUX
TM6 239 S 6.50x50 MC4 receptor 7F54 - -
TM6 240 H 6.51x51 MC4 receptor 7F54 AT1 receptor 4ZUD
TM6 241 C 6.52x52 MC4 receptor 7F54 - -
TM6 242 M 6.53x53 MC4 receptor 7F54 - -
TM6 243 I 6.54x54 MC4 receptor 7F54 MT1 receptor 6ME2
TM6 244 K 6.55x55 MC4 receptor 7F54 apelin receptor 5VBL
TM6 245 V 6.56x56 MC4 receptor 7F54 CB1 receptor 5TGZ
TM6 246 F 6.57x57 MC4 receptor 7F54 MC4 receptor 7F54
TM6 247 L 6.58x58 MC4 receptor 7F54 5-HT2B receptor 5TVN
TM6 248 S 6.59x59 MC4 receptor 7F54 CXCR4 3ODU
TM6 249 S 6.60x60 MC4 receptor 7F54 MC4 receptor 7F54
TM6 250 L 6.61x61 MC4 receptor 7F54 ETB receptor 6IGK
ECL3 251 K - - - - -
ECL3 252 F - - - - -
ECL3 253 H - - - - -
ECL3 254 I - - - - -
TM7 255 R 7.31x31 MT1 receptor 6ME2 LPA6 receptor 5XSZ
TM7 256 R 7.32x32 MT1 receptor 6ME2 CXCR2 6LFL
TM7 257 F 7.33x33 MC4 receptor 7F54 Rhodopsin 1U19
TM7 258 I 7.34x34 MC4 receptor 7F54 CXCR4 3ODU
TM7 259 F 7.35x35 MC4 receptor 7F54 GPR52 6LI1
TM7 260 L 7.36x36 MC4 receptor 7F54 MC4 receptor 7F54
TM7 261 F 7.37x37 MC4 receptor 7F54 5-HT2C receptor 6BQH
TM7 262 F 7.38x38 MC4 receptor 7F54 ghrelin receptor 7F83
TM7 263 I 7.39x39 MC4 receptor 7F54 MC4 receptor 7F54
TM7 264 L 7.40x40 MC4 receptor 7F54 MC4 receptor 7F54
TM7 265 V 7.41x41 MC4 receptor 7F54 OX2 receptor 5WQC
TM7 266 I 7.42x42 MC4 receptor 7F54 CXCR2 6LFL
TM7 267 G 7.43x43 MC4 receptor 7F54 A1 receptor 5UEN
TM7 268 I 7.44x44 - - - -
TM7 269 Y 7.45x45 MC4 receptor 7F54 - -
TM7 270 P 7.46x46 MC4 receptor 7F54 EP4 receptor 5YWY
TM7 271 S 7.47x47 MC4 receptor 7F54 κ receptor 4DJH
TM7 272 G 7.48x48 MC4 receptor 7F54 - -
TM7 273 H 7.49x49 MC4 receptor 7F54 - -
TM7 274 S 7.50x50 MC4 receptor 7F54 - -
TM7 275 L 7.51x51 MC4 receptor 7F54 MC4 receptor 7F54
TM7 276 I 7.52x52 MC4 receptor 7F54 MC4 receptor 7F54
TM7 277 L 7.53x53 MC4 receptor 7F54 ETB receptor 5X93
TM7 278 I 7.54x54 MC4 receptor 7F54 Rhodopsin 1U19
TM7 279 L 7.55x55 MC4 receptor 7F54 MC4 receptor 7F54
TM7 280 G 7.56x56 MC4 receptor 7F54 - -
H8 281 N 8.47x47 MC4 receptor 7F54 5-HT2C receptor 6BQH
H8 282 P 8.48x48 MC4 receptor 7F54 β2-adrenoceptor 4GBR
H8 283 K 8.49x49 MC4 receptor 7F54 ghrelin receptor 7F83
H8 284 L 8.50x50 MC4 receptor 7F54 MC4 receptor 7F54
H8 285 K 8.51x51 MC4 receptor 7F54 ETB receptor 5X93
H8 286 Q 8.52x52 MC4 receptor 7F54 apelin receptor 5VBL
H8 287 N 8.53x53 MC4 receptor 7F54 - -
H8 288 A 8.54x54 MC4 receptor 7F54 PAR2 5NDD
H8 289 K 8.55x55 MC4 receptor 7F54 MC4 receptor 7F54
H8 290 K 8.56x56 MC4 receptor 7F54 CXCR2 6LFL
H8 291 F 8.57x57 MC4 receptor 7F54 κ receptor 4DJH
H8 292 L 8.58x58 MC4 receptor 7F54 MT2 receptor 6ME7
H8 293 L 8.59x59 MC4 receptor 7F54 MT2 receptor 6ME7
H8 294 H 8.60x60 MC4 receptor 7F54 CB2 receptor 5ZTY
C-term 295 S - - - - -
C-term 296 K - - - - -
C-term 297 C - - - - -
C-term 298 C - - - - -
C-term 299 Q - - - - -