angiotensin II


SMILES None
InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
Sequence DRVYIHPF

Chemical properties

Hydrogen bond acceptors None
Hydrogen bond donors None
Rotatable bonds None
Molecular weight (Da)

Drug properties

Molecular type Peptide
Endogenous/Surrogate Endogenous
Approved drug Yes

Database connections

Structure pdb 6OS0 6JOD

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 Guide to Pharmacology
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.41 7.41 7.41 Guide to Pharmacology
α2A ADA2A Human Adrenoceptors A pKi 7.7 7.7 7.7 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pKi 7.74 7.74 7.74 Guide to Pharmacology
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 ChEMBL
D1 DRD1 Rat Dopamine A pKi 5.38 5.38 5.38 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 7.75 7.75 7.75 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.58 6.58 6.58 ChEMBL
α2A ADA2A Human Adrenoceptors A pKi 7.7 7.7 7.7 ChEMBL
H1 HRH1 Human Histamine A pKi 8.8 8.8 8.8 ChEMBL
D2 DRD2 Rat Dopamine A pKi 5.84 5.84 5.84 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.41 7.41 7.41 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 5.3 5.3 5.3 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.75 7.75 7.75 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.16 7.62 8.09 ChEMBL
D3 DRD3 Human Dopamine A pKi 5.24 5.24 5.24 ChEMBL
H1 HRH1 Rat Histamine A pKi 9.2 9.33 9.5 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.3 5.49 5.84 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 7.74 7.74 7.74 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 5.24 6.47 7.7 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.26 8.26 8.26 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.16 7.16 7.16 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 5.38 5.38 5.38 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.26 5.26 5.26 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.41 7.73 8.05 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.58 6.58 6.58 PDSP Ki database
α2A ADA2A Human Adrenoceptors A pKi 7.7 7.7 7.7 PDSP Ki database
α2C ADA2C Human Adrenoceptors A pKi 7.74 7.74 7.74 PDSP Ki database
H1 HRH1 Human Histamine A pKi 8.8 9.05 9.3 PDSP Ki database
α1D ADA1D Human Adrenoceptors A pKi 6.43 6.43 6.43 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKd 8.28 8.28 8.28 Drug Central
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 8.13 8.13 8.13 Drug Central
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 8.18 8.18 8.18 Drug Central
α2A ADA2A Human Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
α2C ADA2C Human Adrenoceptors A pKi 8.11 8.11 8.11 Drug Central
D1 DRD1 Human Dopamine A pKi 8.27 8.27 8.27 Drug Central
D2 DRD2 Human Dopamine A pKi 8.28 8.28 8.28 Drug Central
D3 DRD3 Human Dopamine A pKi 8.28 8.28 8.28 Drug Central
H1 HRH1 Human Histamine A pKi 8.06 8.06 8.06 Drug Central
D1 DRD1 Rat Dopamine A pKi 8.27 8.27 8.27 Drug Central
D2 DRD2 Rat Dopamine A pKi 8.23 8.23 8.23 Drug Central
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 8.15 8.15 8.15 Drug Central
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 8.08 8.08 8.08 Drug Central
H1 HRH1 Guinea pig Histamine A pKi 8.29 8.29 8.29 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
α2A ADA2A Human Adrenoceptors A pIC50 7.1 7.1 7.1 Guide to Pharmacology
α2B ADA2B Human Adrenoceptors A pIC50 6.7 6.7 6.7 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pIC50 6.7 6.7 6.7 Guide to Pharmacology
α2C ADA2C Human Adrenoceptors A pIC50 6.7 6.7 6.7 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 5.5 5.5 5.5 ChEMBL
α2A ADA2A Human Adrenoceptors A pIC50 7.07 7.07 7.07 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.5 4.5 4.5 ChEMBL
α1A ADA1A Human Adrenoceptors A pIC50 8.26 8.26 8.26 Drug Central
α2B ADA2B Human Adrenoceptors A pIC50 8.18 8.18 8.18 Drug Central
α2B ADA2B Human Adrenoceptors A pIC50 6.65 6.65 6.65 ChEMBL