bromocriptine


SMILES CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C
InChIKey OZVBMTJYIDMWIL-AYFBDAFISA-N

Chemical properties

Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 5
Molecular weight (Da) 653.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 6VMS 7JVR
Ligand site mutations D2

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.7 7.8 7.9 Guide to Pharmacology
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.1 8.15 8.2 Guide to Pharmacology
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.7 6.85 7.0 Guide to Pharmacology
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.1 7.1 7.1 Guide to Pharmacology
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 7.0 7.0 7.0 Guide to Pharmacology
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.5 7.6 7.7 Guide to Pharmacology
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 8.3 8.35 8.4 Guide to Pharmacology
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 7.18 7.33 7.41 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.27 7.54 7.74 PDSP Ki database
5-HT1D A0A4W2F4L6 Hybrid cattle 5-Hydroxytryptamine A pKi 7.82 7.83 7.83 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.17 8.04 8.35 PDSP Ki database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.08 7.08 7.08 PDSP Ki database
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 7.92 8.09 8.21 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 7.27 7.27 7.27 PDSP Ki database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.92 8.02 8.13 PDSP Ki database
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.04 8.04 8.04 PDSP Ki database
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.04 8.04 8.04 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 8.0 8.0 8.0 Guide to Pharmacology
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 7.97 7.98 8.0 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 8.21 8.21 8.21 ChEMBL
5-HT1E 5HT1E Human 5-Hydroxytryptamine A pKi 6.68 6.68 6.68 PDSP Ki database
5-HT1F 5HT1F Human 5-Hydroxytryptamine A pKi 7.3 7.3 7.3 Guide to Pharmacology
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.42 8.6 9.05 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 8.4 8.7 9.0 Guide to Pharmacology
5-HT5A 5HT5A Human 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.92 6.96 6.98 PDSP Ki database
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 6.92 6.97 7.0 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 7.08 7.08 7.08 ChEMBL
5-HT6 5HT6R Rat 5-Hydroxytryptamine A pKi 6.98 6.98 6.98 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.96 7.96 7.96 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 7.75 7.89 7.96 ChEMBL
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 6.56 6.89 7.4 PDSP Ki database
5-HT7 5HT7R Rat 5-Hydroxytryptamine A pKi 7.08 7.41 7.74 ChEMBL
5-HT5A 5HT5A Mouse 5-Hydroxytryptamine A pKi 7.4 7.4 7.4 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pIC50 7.21 7.21 7.21 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 7.8 7.8 7.8 ChEMBL
M1 ACM1 Rat Acetylcholine (muscarinic) A Potency 4.6 4.82 5.05 ChEMBL