GPCRdb

vortioxetine

Agent/drug
Bioactivity

vortioxetine

SMILES	Cc1ccc(Sc2ccccc2N2CCNCC2)c(C)c1
InChIKey	YQNWZWMKLDQSAC-UHFFFAOYSA-N

Chemical Properties

Hydrogen bond acceptors	3
Hydrogen bond donors	1
Rotatable bonds	3
Molecular weight (Da)	298.2

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem PubChem PubChem GPCRdb

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

β₁	ADRB1	Human	Adrenoceptors	A	pKi	7.34	7.34	7.34	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	6.25	6.25	6.25	ChEMBL
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.20	8.20	8.20	Drug Central
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.82	7.82	7.82	Guide to Pharmacology
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	7.41	7.88	8.02	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.11	8.11	8.11	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	7.48	7.48	7.48	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.13	8.13	8.13	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	7.48	7.48	7.48	Guide to Pharmacology
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.14	8.14	8.14	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	6.75	6.75	6.75	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	6.75	6.75	6.75	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	6.66	6.66	6.66	Guide to Pharmacology
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	6.66	6.66	6.66	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.48	6.48	6.48	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	6.48	6.48	6.48	ChEMBL

Showing 1 to 20 of 29 entries

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Receptor					Activity				Source

Protein	Gene	Species	Family	Class	Type	Min	Avg	Max	Database

5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pEC50	6.70	6.70	6.70	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pEC50	6.92	6.92	6.92	ChEMBL
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pIC50	5.40	5.40	5.40	Guide to Pharmacology
5-HT_1D	5HT1D	Rat	5-Hydroxytryptamine	A	pIC50	8.27	8.27	8.27	Drug Central

Showing 1 to 4 of 4 entries

vortioxetine

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Clinical Trials

Phase I 0

Phase II 18

Phase III 6

Approved Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids Drug Central DrugBank PubChem PubChem PubChem GPCRdb

Sankey plot

Drug Information

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Target					Disease				Phase

Gene	Protein	Receptor family	Ligand type	Class	Indication name	ICD11	ATC	Association score	Phase	Approved

5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	N06A	0.503	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N06A	0.591	2	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.596	4	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Generalised anxiety disorder	6B00	N06A	0.543	3	Yes
5HT1A	5-HT_1A receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N06A	0.634	4	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	N06A	0.039	2	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N06A	0.076	2	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.409	4	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Generalised anxiety disorder	6B00	N06A	0.004	3	Yes
5HT1B	5-HT_1B receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N06A	0.102	4	Yes
5HT7R	5-HT₇ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Attention deficit hyperactivity disorder, presentation unspecified	6A05.Z	N06A	0.020	2	Yes
5HT7R	5-HT₇ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Bipolar type I disorder, unspecified	6A60.Z	N06A	0.102	2	Yes
5HT7R	5-HT₇ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Depressive disorders, unspecified	6A7Z	N06A	0.404	4	Yes
5HT7R	5-HT₇ receptor	5-Hydroxytryptamine receptors	Aminergic receptors	Class A	Single episode depressive disorder, severe, without psychotic symptoms	6A70.3	N06A	0.101	4	Yes

Showing 1 to 14 of 14 entries

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vortioxetine

vortioxetine

Chemical Properties

Database connections

Bioactivities

vortioxetine

Drug properties

Clinical Trials

Database connections

Sankey plot

Drug Information