lisuride


SMILES CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC
InChIKey BKRGVLQUQGGVSM-KBXCAEBGSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 3
Molecular weight (Da) 338.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug Yes

Database connections

Structure pdb 6DRX 7UM6 7WC7
Ligand site mutations 5-HT1A 5-HT2A 5-HT2B 5-HT2C 5-HT5A 5-HT6 D2 D3

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Rat Metabotropic glutamate C pKd 8.38 8.38 8.38 Guide to Pharmacology
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 7.85 7.85 7.85 Guide to Pharmacology
mGlu2 GRM2 Human Metabotropic glutamate C pEC50 7.51 7.68 7.85 ChEMBL