GPCRdb

risperidone

SMILES	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2
InChIKey	RAPZEAPATHNIPO-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors	6
Hydrogen bond donors	0
Rotatable bonds	4
Molecular weight (Da)	410.2

Drug properties

Molecular type	Small molecule
Physiological/Surrogate	Surrogate
Approved drug	Yes

Database connections

PubChem Guide To Pharmacology ChEMBL_compound_ids DrugBank Drug Central GPCRdb
Structure pdb	6A93 6CM4
Ligand site mutations	5-HT_2A D₂

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	6.4	6.45	6.5	Guide to Pharmacology
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.2	6.2	6.2	Guide to Pharmacology
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.14	6.62	6.89	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.93	6.61	7.68	ChEMBL
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKd	6.4	6.4	6.4	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	6.31	6.8	7.68	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	5.93	6.48	6.8	PDSP Ki database
5-HT_1A	5HT1A	Human	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pKi	8.16	8.16	8.16	Drug Central
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.6	6.95	7.3	Guide to Pharmacology
5-HT_1B	5HT1B	Rat	5-Hydroxytryptamine	A	pKi	5.4	5.62	5.88	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	6.14	7.28	8.01	PDSP Ki database
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.0	8.0	8.0	ChEMBL
5-HT_1B	5HT1B	Human	5-Hydroxytryptamine	A	pKi	8.13	8.13	8.13	Drug Central
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	7.8	7.9	8.0	Guide to Pharmacology
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.0	6.0	6.0	ChEMBL
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	6.85	7.74	8.41	PDSP Ki database
5-HT_1D	F1MMU1	Bovine	5-Hydroxytryptamine	A	pKi	7.0	7.11	7.22	PDSP Ki database
5-HT_1D	5HT1D	Human	5-Hydroxytryptamine	A	pKi	8.12	8.12	8.12	Drug Central
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.9	5.9	5.9	Guide to Pharmacology
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	5.0	5.44	5.88	PDSP Ki database
5-HT_1E	5HT1E	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	5.9	5.9	5.9	Guide to Pharmacology
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	5.91	5.91	5.91	PDSP Ki database
5-HT_1F	5HT1F	Human	5-Hydroxytryptamine	A	pKi	8.23	8.23	8.23	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	9.3	9.65	10.0	Guide to Pharmacology
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	8.5	8.5	8.5	Guide to Pharmacology
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	9.0	9.43	10.0	ChEMBL
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.15	9.41	9.85	PDSP Ki database
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	8.85	9.65	10.8	PDSP Ki database
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pKi	8.03	8.03	8.03	Drug Central
5-HT_2A	5HT2A	Rat	5-Hydroxytryptamine	A	pKi	8.01	8.01	8.01	Drug Central
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	7.7	7.76	7.82	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	6.94	7.41	7.8	PDSP Ki database
5-HT_2B	5HT2B	Rat	5-Hydroxytryptamine	A	pKi	6.69	6.69	6.69	PDSP Ki database
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pKi	8.13	8.13	8.13	Drug Central
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	6.9	7.51	7.84	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.0	7.65	8.19	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.19	7.66	8.0	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	7.02	7.52	8.19	PDSP Ki database
5-HT_2C	K7GSR7	Pig	5-Hydroxytryptamine	A	pKi	7.2	7.39	7.66	PDSP Ki database
5-HT_2C	5HT2C	Rat	5-Hydroxytryptamine	A	pKi	8.11	8.11	8.11	Drug Central
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	7.5	7.55	7.6	Guide to Pharmacology
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pKi	8.11	8.11	8.11	Drug Central
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	6.0	6.0	6.0	ChEMBL
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	6.69	6.7	6.71	PDSP Ki database
5-HT_5A	5HT5A	Human	5-Hydroxytryptamine	A	pKi	8.17	8.17	8.17	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.6	5.6	5.6	Guide to Pharmacology
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	6.0	6.2	6.4	Guide to Pharmacology
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.7	5.97	6.65	ChEMBL
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	5.95	6.29	6.38	PDSP Ki database
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	5.62	5.79	6.02	PDSP Ki database
5-HT₆	5HT6R	Rat	5-Hydroxytryptamine	A	pKi	8.19	8.19	8.19	Drug Central
5-HT₆	5HT6R	Human	5-Hydroxytryptamine	A	pKi	8.18	8.18	8.18	Drug Central
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.3	8.5	8.7	Guide to Pharmacology
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	7.39	8.24	8.85	ChEMBL
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.0	8.69	9.4	ChEMBL
5-HT₇	5HT7R	Mouse	5-Hydroxytryptamine	A	pKi	8.8	8.8	8.8	PDSP Ki database
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	8.3	8.76	9.03	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.16	8.47	9.4	PDSP Ki database
5-HT₇	5HT7R	Guinea pig	5-Hydroxytryptamine	A	pKi	9.4	9.4	9.4	PDSP Ki database
5-HT₇	5HT7R	Human	5-Hydroxytryptamine	A	pKi	8.07	8.07	8.07	Drug Central
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKi	8.05	8.05	8.05	Drug Central
5-HT₇	5HT7R	Rat	5-Hydroxytryptamine	A	pKd	8.9	8.95	9.0	Guide to Pharmacology
CCK₂	GASR	Rat	Cholecystokinin	A	pKi	6.0	6.0	6.0	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	6.6	7.1	7.66	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	6.0	6.6	7.68	ChEMBL
D₁	DRD1	Human	Dopamine	A	pKi	6.24	6.56	7.22	PDSP Ki database
D₁	DRD1	Rat	Dopamine	A	pKi	5.0	6.6	7.68	PDSP Ki database
D₁	DRD1	Human	Dopamine	A	pKi	8.11	8.11	8.11	Drug Central
D₁	DRD1	Rat	Dopamine	A	pKi	8.12	8.12	8.12	Drug Central
D₂	DRD2	Human	Dopamine	A	pKi	9.36	9.36	9.36	Guide to Pharmacology
D₂	DRD2	Rat	Dopamine	A	pKi	7.72	8.37	8.74	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	8.0	8.46	9.36	ChEMBL
D₂	DRD2	Human	Dopamine	A	pKi	7.57	8.61	9.52	PDSP Ki database
D₂	DRD2	Rat	Dopamine	A	pKi	7.7	8.68	9.36	PDSP Ki database
D₂	A0A287B0Q7	Pig	Dopamine	A	pKi	7.43	8.29	9.08	PDSP Ki database
D₂	DRD2	Human	Dopamine	A	pKi	8.07	8.07	8.07	Drug Central
D₂	DRD2	Rat	Dopamine	A	pKi	8.06	8.06	8.06	Drug Central
D₃	DRD3	Human	Dopamine	A	pKi	7.0	7.0	7.0	Guide to Pharmacology
D₃	DRD3	Rat	Dopamine	A	pKi	7.5	7.84	8.01	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	7.0	7.84	8.17	ChEMBL
D₃	DRD3	Human	Dopamine	A	pKi	7.8	8.24	8.8	PDSP Ki database
D₃	DRD3	Rat	Dopamine	A	pKi	7.89	8.14	8.55	PDSP Ki database
D₃	DRD3	Human	Dopamine	A	pKi	8.09	8.09	8.09	Drug Central
D₃	DRD3	Rat	Dopamine	A	pKi	8.1	8.1	8.1	Drug Central
D₄	DRD4	Human	Dopamine	A	pKi	7.0	7.86	8.21	ChEMBL
D₄	DRD4	Human	Dopamine	A	pKi	7.73	8.39	9.6	PDSP Ki database
D₄	DRD4	Rat	Dopamine	A	pKi	7.78	7.95	8.12	PDSP Ki database
D₄	DRD4	Human	Dopamine	A	pKi	8.1	8.1	8.1	Drug Central
D₅	DRD5	Human	Dopamine	A	pKi	6.0	6.0	6.0	ChEMBL
D₅	DRD5	Human	Dopamine	A	pKi	6.25	7.03	7.8	PDSP Ki database
D₅	DRD5	Human	Dopamine	A	pKi	8.15	8.15	8.15	Drug Central
EP₃	PE2R3	Human	Prostanoid	A	pKi	5.0	5.0	5.0	PDSP Ki database
EP₄	PE2R4	Human	Prostanoid	A	pKi	5.0	5.0	5.0	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	7.6	7.7	7.8	Guide to Pharmacology
H₁	HRH1	Guinea pig	Histamine	A	pKi	7.33	7.55	8.1	ChEMBL
H₁	HRH1	Human	Histamine	A	pKi	7.0	7.67	8.59	ChEMBL
H₁	HRH1	Guinea pig	Histamine	A	pKi	8.59	8.59	8.59	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	7.48	7.81	8.29	PDSP Ki database
H₁	HRH1	Rat	Histamine	A	pKi	6.8	6.89	7.06	PDSP Ki database
H₁	HRH1	Human	Histamine	A	pKi	8.13	8.13	8.13	Drug Central
H₁	HRH1	Guinea pig	Histamine	A	pKi	8.12	8.12	8.12	Drug Central
H₂	HRH2	Human	Histamine	A	pKi	5.84	5.84	5.84	ChEMBL
H₂	HRH2	Human	Histamine	A	pKi	6.92	6.92	6.92	PDSP Ki database
H₂	HRH2	Human	Histamine	A	pKi	8.16	8.16	8.16	Drug Central
H₃	HRH3	Human	Histamine	A	pKi	5.96	5.96	5.96	ChEMBL
H₃	HRH3	Guinea pig	Histamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
H₄	HRH4	Human	Histamine	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	5.55	5.55	5.55	ChEMBL
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.21	5.55	PDSP Ki database
M₁	ACM1	Human	Acetylcholine (muscarinic)	A	pKi	8.26	8.26	8.26	Drug Central
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.16	5.43	PDSP Ki database
M₂	ACM2	Human	Acetylcholine (muscarinic)	A	pKi	8.27	8.27	8.27	Drug Central
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
M₃	ACM3	Rat	Acetylcholine (muscarinic)	A	pKi	5.07	5.07	5.07	PDSP Ki database
M₃	ACM3	Human	Acetylcholine (muscarinic)	A	pKi	8.3	8.3	8.3	Drug Central
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.18	5.54	PDSP Ki database
M₄	ACM4	Human	Acetylcholine (muscarinic)	A	pKi	8.26	8.26	8.26	Drug Central
M₅	ACM5	Human	Acetylcholine (muscarinic)	A	pKi	5.0	5.0	5.0	PDSP Ki database
PAF	PTAFR	Human	Platelet-activating factor	A	pKi	6.0	6.0	6.0	PDSP Ki database
TP	TA2R	Human	Prostanoid	A	pKi	6.0	6.0	6.0	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.4	8.55	8.7	Guide to Pharmacology
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	7.89	8.78	9.4	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.0	8.42	8.64	ChEMBL
α_1A	Q9TSW7	Pig	Adrenoceptors	A	pKi	7.8	8.67	9.3	PDSP Ki database
α_1A	ADA1A	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1A	ADA1A	Rat	Adrenoceptors	A	pKi	8.1	8.1	8.1	Drug Central
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	7.8	7.9	8.0	Guide to Pharmacology
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.97	8.97	8.97	ChEMBL
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.0	8.0	8.0	ChEMBL
α_1B	A0A4X1U0M4	Pig	Adrenoceptors	A	pKi	8.5	8.5	8.5	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.05	8.05	8.05	PDSP Ki database
α_1B	ADA1B	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
α_1B	ADA1B	Rat	Adrenoceptors	A	pKi	8.05	8.05	8.05	Drug Central
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	7.4	7.4	7.4	Guide to Pharmacology
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.31	8.31	8.31	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.3	8.3	8.3	PDSP Ki database
α_1D	ADA1D	Human	Adrenoceptors	A	pKi	8.13	8.13	8.13	Drug Central
α_2A	ADA2A	Rat	Adrenoceptors	A	pKi	7.6	7.6	7.6	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.0	7.5	8.44	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	6.82	7.32	8.0	PDSP Ki database
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	8.1	8.1	8.1	Drug Central
α_2A	ADA2A	Human	Adrenoceptors	A	pKi	7.3	7.3	7.3	Guide to Pharmacology
α_2A	ADA2A	Rat	Adrenoceptors	A	pKi	8.12	8.12	8.12	Drug Central
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.0	6.96	7.92	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	6.97	7.34	8.07	PDSP Ki database
α_2B	ADA2B	Human	Adrenoceptors	A	pKi	8.11	8.11	8.11	Drug Central
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.0	8.45	8.86	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.04	8.58	8.89	PDSP Ki database
α_2C	ADA2C	Human	Adrenoceptors	A	pKi	8.07	8.07	8.07	Drug Central
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	4.66	4.66	4.66	ChEMBL
β₁	ADRB1	Human	Adrenoceptors	A	pKi	5.0	5.15	5.3	PDSP Ki database
β₁	ADRB1	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
β₁	ADRB1	Rat	Adrenoceptors	A	pKi	8.33	8.33	8.33	Drug Central
β₂	ADRB2	Human	Adrenoceptors	A	pKi	5.0	5.15	5.3	PDSP Ki database
β₂	ADRB2	Human	Adrenoceptors	A	pKi	8.28	8.28	8.28	Drug Central
δ	OPRD	Mouse	Opioid	A	pKi	6.0	6.0	6.0	PDSP Ki database
κ	OPRK	Guinea pig	Opioid	A	pKi	6.0	6.0	6.0	PDSP Ki database
μ	OPRM	Rat	Opioid	A	pKi	6.0	6.0	6.0	PDSP Ki database

Showing 1 to 160 of 160 entries

Search:

Receptor					Activity				Source
GTP No matches found	Uniprot No matches found	Species No matches found	Family No matches found	Class No matches found	Type No matches found	Min	Avg	Max	Database No matches found
5-HT_1A	5HT1A	Mouse	5-Hydroxytryptamine	A	pIC50	6.37	6.37	6.37	ChEMBL
5-HT_1A	5HT1A	Rat	5-Hydroxytryptamine	A	pIC50	6.02	6.06	6.1	ChEMBL
5-HT_1A	5HT1A	Mouse	5-Hydroxytryptamine	A	pIC50	8.2	8.2	8.2	Drug Central
5-HT_2A	5HT2A	Human	5-Hydroxytryptamine	A	pIC50	8.33	9.02	9.46	ChEMBL
5-HT_2B	5HT2B	Human	5-Hydroxytryptamine	A	pIC50	7.64	7.64	7.64	ChEMBL
5-HT_2C	5HT2C	Human	5-Hydroxytryptamine	A	pIC50	7.82	8.39	8.74	ChEMBL
D₁	DRD1	Human	Dopamine	A	pIC50	6.32	6.32	6.32	ChEMBL
D₂	DRD2	Mouse	Dopamine	A	pIC50	7.64	7.64	7.64	ChEMBL
D₂	DRD2	Rat	Dopamine	A	pIC50	7.43	7.63	8.4	ChEMBL
D₂	DRD2	Human	Dopamine	A	pIC50	7.7	7.93	8.15	ChEMBL
D₂	DRD2	Mouse	Dopamine	A	pIC50	8.12	8.12	8.12	Drug Central
D₃	DRD3	Human	Dopamine	A	pIC50	7.62	7.62	7.62	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	7.1	7.1	7.1	ChEMBL
H₁	HRH1	Human	Histamine	A	pIC50	6.06	6.5	7.6	ChEMBL
H₁	HRH1	Rat	Histamine	A	pIC50	8.15	8.15	8.15	Drug Central
H₂	HRH2	Human	Histamine	A	pIC50	5.83	5.83	5.83	ChEMBL
M₁	ACM1	Rat	Acetylcholine (muscarinic)	A	Potency	4.75	4.83	4.9	ChEMBL
TSH	TSHR	Human	Glycoprotein hormone	A	Potency	5.1	5.1	5.1	ChEMBL
α_1A	ADA1A	Rat	Adrenoceptors	A	pIC50	9.01	9.01	9.01	ChEMBL
α_1A	ADA1A	Human	Adrenoceptors	A	pIC50	7.96	7.98	8.0	ChEMBL
α_1B	ADA1B	Rat	Adrenoceptors	A	pIC50	8.71	8.71	8.71	ChEMBL
α_1D	ADA1D	Human	Adrenoceptors	A	pIC50	8.0	8.0	8.0	ChEMBL
α_2A	ADA2A	Human	Adrenoceptors	A	pIC50	8.01	8.01	8.01	ChEMBL
α_2B	ADA2B	Human	Adrenoceptors	A	pIC50	7.58	7.58	7.58	ChEMBL
α_2C	ADA2C	Human	Adrenoceptors	A	pIC50	8.02	8.02	8.02	ChEMBL

Showing 1 to 25 of 25 entries

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risperidone

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