Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
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 Assay
Type

 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
15931130 102036 None 0 Rat Functional pEC50 = 9.4 9.4 1000 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL301477 102036 None 0 Rat Functional pEC50 = 9.4 9.4 1000 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297866 102099 None 0 Rat Functional pEC50 = 9.4 9.4 38 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL301841 102099 None 0 Rat Functional pEC50 = 9.4 9.4 38 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
2089 2766 None 25 Rat Functional pEC50 = 9.3 9.3 -3 8
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
3795 2766 None 25 Rat Functional pEC50 = 9.3 9.3 -3 8
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
5311311 2766 None 25 Rat Functional pEC50 = 9.3 9.3 -3 8
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
CHEMBL217406 2766 None 25 Rat Functional pEC50 = 9.3 9.3 -3 8
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetryAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
ChEMBL None None None None 10.1021/jm900671k
2098 3694 None 31 Rat Functional pEC50 = 9 9.0 -63 11
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
36511 3694 None 31 Rat Functional pEC50 = 9 9.0 -63 11
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3805 3694 None 31 Rat Functional pEC50 = 9 9.0 -63 11
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3835 3694 None 31 Rat Functional pEC50 = 9 9.0 -63 11
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3694 None 31 Rat Functional pEC50 = 9 9.0 -63 11
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
44355179 24356 None 0 Rat Functional pEC50 = 8.9 8.9 33 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134091 24356 None 0 Rat Functional pEC50 = 8.9 8.9 33 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 962 30 11 13 -2.2 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(C)=O)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
2089 2766 None 25 Rat Functional pEC50 = 8.8 8.8 -3 8
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3795 2766 None 25 Rat Functional pEC50 = 8.8 8.8 -3 8
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
5311311 2766 None 25 Rat Functional pEC50 = 8.8 8.8 -3 8
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL217406 2766 None 25 Rat Functional pEC50 = 8.8 8.8 -3 8
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
73356363 89538 None 0 Rat Functional pEC50 = 8.0 8.0 -9 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372949 89538 None 0 Rat Functional pEC50 = 8.0 8.0 -9 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10055612 96478 None 0 Rat Functional pEC50 = 5.9 5.9 -31 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262049 96478 None 0 Rat Functional pEC50 = 5.9 5.9 -31 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 711 23 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
10327810 116800 None 0 Rat Functional pEC50 = 5.9 5.9 31 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337465 116800 None 0 Rat Functional pEC50 = 5.9 5.9 31 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
10259515 157229 None 0 Rat Functional pEC50 = 4.9 4.9 -954 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL407511 157229 None 0 Rat Functional pEC50 = 4.9 4.9 -954 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
44355678 23497 None 0 Rat Functional pEC50 = 5.9 5.9 -4 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL133362 23497 None 0 Rat Functional pEC50 = 5.9 5.9 -4 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 777 21 5 8 2.3 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC[C@]2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
10462850 24271 None 0 Rat Functional pEC50 = 7.8 7.8 36 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134012 24271 None 0 Rat Functional pEC50 = 7.8 7.8 36 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
2098 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
36511 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3805 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
3835 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL235363 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
2098 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
36511 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3805 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
3835 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
CHEMBL235363 3694 None 31 Rat Functional pEC50 = 6.8 6.8 -63 11
Agonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosaeAgonist activity was measured at neurokinin-2 receptor in the rat colon muscularis mucosae
ChEMBL None None None None 10.1021/jm00169a003
73348740 89540 None 0 Rat Functional pEC50 = 6.7 6.7 -51 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL2372953 89540 None 0 Rat Functional pEC50 = 6.7 6.7 -51 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 737 21 6 8 1.4 CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297675 100674 None 0 Rat Functional pEC50 = 8.6 8.6 47 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL291903 100674 None 0 Rat Functional pEC50 = 8.6 8.6 47 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 711 22 7 8 0.9 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
10395375 116721 None 0 Rat Functional pEC50 = 5.7 5.7 2 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL337037 116721 None 0 Rat Functional pEC50 = 5.7 5.7 2 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@H]2C1=O)C(N)=O 10.1021/jm00100a027
2090 2767 None 27 Rat Functional pEC50 = 7.6 7.6 -6 9
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
5311312 2767 None 27 Rat Functional pEC50 = 7.6 7.6 -6 9
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL437797 2767 None 27 Rat Functional pEC50 = 7.6 7.6 -6 9
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None None 10.1021/jm00100a027
CHEMBL335054 213939 None 0 Rat Functional pEC50 = 8.5 8.5 20 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
5311135 21730 None 12 Rat Functional pEC50 = 8.4 8.4 316 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131872 21730 None 12 Rat Functional pEC50 = 8.4 8.4 316 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 920 29 11 13 -2.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL134481 211188 None 0 Rat Functional pEC50 = 7.5 7.5 1 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(N)=O 10.1021/jm00100a027
44355648 97177 None 0 Rat Functional pEC50 = 7.4 7.4 22 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL267712 97177 None 0 Rat Functional pEC50 = 7.4 7.4 22 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 994 29 10 13 -1.5 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C2C1=O)C(N)=O 10.1021/jm00100a027
10350201 117225 None 0 Rat Functional pEC50 = 6.3 6.3 6 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL339391 117225 None 0 Rat Functional pEC50 = 6.3 6.3 6 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 763 21 5 8 1.8 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1C[C@@H]2CCN(C(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)CCCCN)[C@@H]2C1=O)C(N)=O 10.1021/jm00100a027
44355117 21795 None 0 Rat Functional pEC50 = 7.2 7.2 19 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL131923 21795 None 0 Rat Functional pEC50 = 7.2 7.2 19 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 946 28 10 13 -2.1 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CC2CCN(C(=O)[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CCCCN)C(C)C)C2C1=O)C(N)=O 10.1021/jm00100a027
44297786 101764 None 0 Rat Functional pEC50 = 7.2 7.2 - 1
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL299503 101764 None 0 Rat Functional pEC50 = 7.2 7.2 - 1
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 723 21 6 8 1.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
44355368 25649 None 0 Rat Functional pEC50 = 7.2 7.2 1 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
CHEMBL135186 25649 None 0 Rat Functional pEC50 = 7.2 7.2 1 3
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 737 22 6 8 1.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)N1CCC(NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCCN)C1=O)C(N)=O 10.1021/jm00100a027
2089 2766 None 25 Rat Functional pEC50 = 7.2 7.2 -3 8
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
3795 2766 None 25 Rat Functional pEC50 = 7.2 7.2 -3 8
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
5311311 2766 None 25 Rat Functional pEC50 = 7.2 7.2 -3 8
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
CHEMBL217406 2766 None 25 Rat Functional pEC50 = 7.2 7.2 -3 8
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassayAllosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
ChEMBL None None None None 10.1021/jm900671k
15931129 197222 None 0 Rat Functional pEC50 = 8.2 8.2 -1 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
CHEMBL54622 197222 None 0 Rat Functional pEC50 = 8.2 8.2 -1 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 697 22 7 8 0.6 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCN)C(N)=O 10.1021/jm00169a003
44297852 99061 None 0 Rat Functional pEC50 = 8.1 8.1 7 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
CHEMBL280020 99061 None 0 Rat Functional pEC50 = 8.1 8.1 7 2
Agonist activity at tachykinin receptor 2 in the rat colon muscularis mucosaeAgonist activity at tachykinin receptor 2 in the rat colon muscularis mucosae
ChEMBL 763 20 5 8 1.9 CSCC[C@H](NC(=O)[C@@H](CC(C)C)N1CCC2(CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)CCCN)C1=O)C(N)=O 10.1021/jm00169a003
11765601 96477 None 0 Rat Functional pEC50 = 7.0 7.0 9 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
CHEMBL262048 96477 None 0 Rat Functional pEC50 = 7.0 7.0 9 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 751 22 6 8 1.8 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(N)=O 10.1021/jm00100a027
10009596 115573 None 0 Rat Functional pEC50 = 7.0 7.0 -1 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
CHEMBL335248 115573 None 0 Rat Functional pEC50 = 7.0 7.0 -1 2
In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.In vitro agonistic activity against tachykinin receptor 2 of rat colon muscularis mucosae.
ChEMBL 663 22 7 8 0.4 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCCCN)C(C)C)C(N)=O 10.1021/jm00100a027
145953024 162685 None 0 Human Functional pIC50 = 5.8 5.8 -4 5
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4168948 162685 None 0 Human Functional pIC50 = 5.8 5.8 -4 5
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C/c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
145952624 162479 None 0 Human Functional pIC50 = 5.5 5.5 -1 4
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4165525 162479 None 0 Human Functional pIC50 = 5.5 5.5 -1 4
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 889 21 2 10 3.3 CC[C@H](C)[C@@H](OC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
10917690 210064 None 1 Human Functional pIC50 = 5.5 5.5 -645 4
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
CHEMBL95051 210064 None 1 Human Functional pIC50 = 5.5 5.5 -645 4
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 471 8 0 5 5.4 COc1ccc(CCN2CCC(C(=O)c3nc4ccccc4n3Cc3ccc(F)cc3)CC2)cc1 10.1016/S0960-894X(97)10097-X
145957924 162187 None 0 Human Functional pIC50 = 5.3 5.3 -1 4
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4161021 162187 None 0 Human Functional pIC50 = 5.3 5.3 -1 4
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 886 20 2 10 3.4 CC[C@H](C)[C@@H](OC(=O)/C=C\c1ccccc1)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL412740 215481 None 0 Human Functional pIC50 = 7.3 7.3 - 1
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccc(/N=C(\S)Cc2ccccc2)cc1)NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCS)C(N)=O 10.1016/S0960-894X(97)00088-7
145958767 162349 None 0 Human Functional pIC50 = 5.3 5.3 1 3
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 932 22 2 11 2.8 CC[C@H](C)[C@@H](OC(=O)[C@H](Cc1ccccc1)N(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
CHEMBL4163618 162349 None 0 Human Functional pIC50 = 5.3 5.3 1 3
Antagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence methodAntagonist activity at human TACR2 expressed in CHOK1 cells assessed as substance P-induced beta-arrestin recruitment pre-incubated for 30 mins before substance P stimulation for 90 or 180 mins by chemiluminescence method
ChEMBL 932 22 2 11 2.8 CC[C@H](C)[C@@H](OC(=O)[C@H](Cc1ccccc1)N(C)C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC 10.1021/acs.jmedchem.8b00885
2089 2766 None 25 Human Functional pIC50 = 8.1 8.1 -3 8
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
3795 2766 None 25 Human Functional pIC50 = 8.1 8.1 -3 8
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
5311311 2766 None 25 Human Functional pIC50 = 8.1 8.1 -3 8
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
CHEMBL217406 2766 None 25 Human Functional pIC50 = 8.1 8.1 -3 8
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None None 10.1016/S0960-894X(97)00088-7
CHEMBL264972 213092 None 0 Human Functional pIC50 = 8.1 8.1 - 1
Tested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin ATested for the binding affinity to human NK2 receptor expressed in Sf-9 insect larval cells using 0.1 nM 2-[125 I] iodohistidyl neurokinin A
ChEMBL None None None CC(C)C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1ccc(NC(=S)c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCS)C(N)=O 10.1016/S0960-894X(97)00088-7
153996 112731 None 0 Human Functional pIC50 = 8.1 8.1 -2 6
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL330366 112731 None 0 Human Functional pIC50 = 8.1 8.1 -2 6
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
CHEMBL539021 112731 None 0 Human Functional pIC50 = 8.1 8.1 -2 6
Compound was evaluated for the antagonistic activity against Tachykinin receptor 2Compound was evaluated for the antagonistic activity against Tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10097-X
44392439 168478 None 0 Rabbit Functional pKd = 10.1 10.1 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434548 168478 None 0 Rabbit Functional pKd = 10.1 10.1 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
11433617 6773 None 0 Human Functional pKd = 9.7 9.7 - 0
Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractionsAntagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083850 6773 None 0 Human Functional pKd = 9.7 9.7 - 0
Antagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractionsAntagonist activity at NK2 receptor in human urinary bladder assessed as inhibition of [beta-Ala8]NKA(4-10)-induced tissue contractions
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44392392 130241 None 0 Rabbit Functional pKd = 9.7 9.7 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367815 130241 None 0 Rabbit Functional pKd = 9.7 9.7 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392491 168413 None 0 Rabbit Functional pKd = 9.7 9.7 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434142 168413 None 0 Rabbit Functional pKd = 9.7 9.7 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392318 122609 None 0 Rabbit Functional pKd = 9.6 9.6 - 0
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL360134 122609 None 0 Rabbit Functional pKd = 9.6 9.6 - 0
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 519 7 0 4 5.0 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
44346720 114899 None 0 Golden hamster Functional pKd = 9.3 9.3 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL334186 114899 None 0 Golden hamster Functional pKd = 9.3 9.3 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
71452717 78929 None 0 Rabbit Functional pKd = 9.2 9.2 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112925 78929 None 0 Rabbit Functional pKd = 9.2 9.2 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
9959481 65240 None 0 Human Functional pKd = 9.2 9.2 - 1
pA2 for NK2 receptor of human bladder IM9 cellspA2 for NK2 receptor of human bladder IM9 cells
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL182600 65240 None 0 Human Functional pKd = 9.2 9.2 - 1
pA2 for NK2 receptor of human bladder IM9 cellspA2 for NK2 receptor of human bladder IM9 cells
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
71449111 78926 None 0 Rabbit Functional pKd = 9.1 9.1 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 78926 None 0 Rabbit Functional pKd = 9.1 9.1 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44346727 168271 None 0 Golden hamster Functional pKd = 9.1 9.1 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433191 168271 None 0 Golden hamster Functional pKd = 9.1 9.1 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374427 54809 None 0 Rabbit Functional pKd = 9 9.0 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL161242 54809 None 0 Rabbit Functional pKd = 9 9.0 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
71458042 78927 None 0 Rabbit Functional pKd = 9 9.0 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112923 78927 None 0 Rabbit Functional pKd = 9 9.0 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44392351 66423 None 0 Rabbit Functional pKd = 9 9.0 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185182 66423 None 0 Rabbit Functional pKd = 9 9.0 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
10929285 66730 None 0 Rabbit Functional pKd = 9 9.0 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL185572 66730 None 0 Rabbit Functional pKd = 9 9.0 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
10940813 66352 None 0 Rabbit Functional pKd = 8.9 8.9 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185007 66352 None 0 Rabbit Functional pKd = 8.9 8.9 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392347 122194 None 0 Rabbit Functional pKd = 8.9 8.9 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359655 122194 None 0 Rabbit Functional pKd = 8.9 8.9 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
9915372 127127 None 1 Rabbit Functional pKd = 8.9 8.9 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 127127 None 1 Rabbit Functional pKd = 8.9 8.9 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9915372 127127 None 1 Human Functional pKd = 8.8 8.8 - 1
pA2 for NK2 receptor of Human bladderpA2 for NK2 receptor of Human bladder
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 127127 None 1 Human Functional pKd = 8.8 8.8 - 1
pA2 for NK2 receptor of Human bladderpA2 for NK2 receptor of Human bladder
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392445 66376 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185133 66376 None 0 Rabbit Functional pKd = 8.8 8.8 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
44346794 15274 None 0 Golden hamster Functional pKd = 8.8 8.8 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL121271 15274 None 0 Golden hamster Functional pKd = 8.8 8.8 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
10972666 123012 None 0 Rabbit Functional pKd = 8.7 8.7 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL360721 123012 None 0 Rabbit Functional pKd = 8.7 8.7 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
10950925 129722 None 0 Rabbit Functional pKd = 8.7 8.7 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367348 129722 None 0 Rabbit Functional pKd = 8.7 8.7 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9830361 181732 None 0 Human Functional pKd = 8 8.0 - 0
Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47739 181732 None 0 Human Functional pKd = 8 8.0 - 0
Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2Cellular functional antagonistic activity against NKB-induced [Ca2+] mobilization in HEK cells stably expressing the tachykinin receptor 2
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
10232566 4219 None 0 Human Functional pKd = 8 8.0 - 0
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100297 4219 None 0 Human Functional pKd = 8 8.0 - 0
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44307677 169367 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 169367 None 0 Guinea pig Functional pKd = 8 8.0 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44370530 49137 None 0 Rat Functional pKd = 7 7.0 - 0
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL156186 49137 None 0 Rat Functional pKd = 7 7.0 - 0
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 639 13 4 7 2.6 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm960213s
9810288 206149 None 0 Guinea pig Functional pKd = 7 7.0 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 206149 None 0 Guinea pig Functional pKd = 7 7.0 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44346881 141610 None 0 Golden hamster Functional pKd = 7 7.0 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL384610 141610 None 0 Golden hamster Functional pKd = 7 7.0 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
10350528 106789 None 0 Rabbit Functional pKd = 5 5.0 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106789 None 0 Rabbit Functional pKd = 5 5.0 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10439730 106813 None 0 Rabbit Functional pKd = 5 5.0 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106813 None 0 Rabbit Functional pKd = 5 5.0 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL413730 215545 None 0 Golden hamster Functional pKd = 4 4.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL217365 211833 None 0 Rabbit Functional pKd = 4 4.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL262647 213002 None 0 Rabbit Functional pKd = 4 4.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
CHEMBL263985 213059 None 0 Rabbit Functional pKd = 4 4.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL329888 213781 None 0 Rabbit Functional pKd = 4 4.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412621 215470 None 0 Rabbit Functional pKd = 4 4.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL413730 215545 None 0 Rabbit Functional pKd = 4 4.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None None 10.1021/jm00014a022
44346487 114194 None 0 Rabbit Functional pKd = 6.0 6.0 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332872 114194 None 0 Rabbit Functional pKd = 6.0 6.0 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346706 168272 None 0 Golden hamster Functional pKd = 7.0 7.0 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433192 168272 None 0 Golden hamster Functional pKd = 7.0 7.0 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL406487 215070 None 0 Golden hamster Functional pKd = 6.0 6.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44347003 164273 None 0 Rabbit Functional pKd = 7.0 7.0 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL421062 164273 None 0 Rabbit Functional pKd = 7.0 7.0 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL216897 211803 None 0 Golden hamster Functional pKd = 5.0 5.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44346707 114559 None 0 Rabbit Functional pKd = 6.9 6.9 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333515 114559 None 0 Rabbit Functional pKd = 6.9 6.9 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL407328 215114 None 0 Golden hamster Functional pKd = 5.9 5.9 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44307898 203930 None 0 Guinea pig Functional pKd = 7.9 7.9 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 203930 None 0 Guinea pig Functional pKd = 7.9 7.9 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44347083 15460 None 0 Golden hamster Functional pKd = 7.9 7.9 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL121571 15460 None 0 Golden hamster Functional pKd = 7.9 7.9 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL385603 214817 None 0 Golden hamster Functional pKd = 5.9 5.9 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44307821 102169 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 102169 None 0 Guinea pig Functional pKd = 6.9 6.9 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
10259370 106804 None 0 Rabbit Functional pKd = 6.9 6.9 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144340 106804 None 0 Rabbit Functional pKd = 6.9 6.9 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 730 12 3 7 3.4 CC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL412189 215435 None 0 Rabbit Functional pKd = 5.9 5.9 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
10418001 106809 None 0 Rabbit Functional pKd = 5.9 5.9 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144348 106809 None 0 Rabbit Functional pKd = 5.9 5.9 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 822 14 3 8 4.9 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCc2ccccc2)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10349900 106805 None 0 Rabbit Functional pKd = 4.9 4.9 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106805 None 0 Rabbit Functional pKd = 4.9 4.9 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10395494 106810 None 0 Rabbit Functional pKd = 4.9 4.9 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144349 106810 None 0 Rabbit Functional pKd = 4.9 4.9 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 12 3 8 4.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OC(C)(C)C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44347084 114317 None 0 Rabbit Functional pKd = 6.9 6.9 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333027 114317 None 0 Rabbit Functional pKd = 6.9 6.9 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346863 166479 None 0 Rabbit Functional pKd = 6.9 6.9 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL427606 166479 None 0 Rabbit Functional pKd = 6.9 6.9 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL263743 213047 None 0 Rabbit Functional pKd = 4.9 4.9 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL385914 214829 None 0 Rabbit Functional pKd = 5.9 5.9 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
CHEMBL439287 216293 None 0 Golden hamster Functional pKd = 5.9 5.9 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL267409 213179 None 0 Golden hamster Functional pKd = 6.9 6.9 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL329888 213781 None 0 Rat Functional pKd = 4.9 4.9 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL387199 214867 None 0 Golden hamster Functional pKd = 5.8 5.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44346488 164283 None 0 Rabbit Functional pKd = 5.8 5.8 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL421071 164283 None 0 Rabbit Functional pKd = 5.8 5.8 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL267409 213179 None 0 Rabbit Functional pKd = 5.8 5.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL329888 213781 None 0 Golden hamster Functional pKd = 4.8 4.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
44346720 114899 None 0 Rabbit Functional pKd = 7.8 7.8 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL334186 114899 None 0 Rabbit Functional pKd = 7.8 7.8 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 849 14 9 8 1.8 CC(C)C[C@@H]1CN[C@@H](CCC(=O)NCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44307679 205975 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 205975 None 0 Guinea pig Functional pKd = 7.8 7.8 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44347003 164273 None 0 Golden hamster Functional pKd = 7.8 7.8 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL421062 164273 None 0 Golden hamster Functional pKd = 7.8 7.8 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 744 11 8 7 1.7 CC(C)C[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL439287 216293 None 0 Rat Functional pKd = 6.8 6.8 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL217365 211833 None 0 Golden hamster Functional pKd = 4.8 4.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44307773 102415 None 0 Guinea pig Functional pKd = 6.8 6.8 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 102415 None 0 Guinea pig Functional pKd = 6.8 6.8 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL429340 215983 None 0 Golden hamster Functional pKd = 5.8 5.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL439284 216292 None 19 Rabbit Functional pKd = 5.8 5.8 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00063a015
10395612 106803 None 0 Rabbit Functional pKd = 4.8 4.8 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144339 106803 None 0 Rabbit Functional pKd = 4.8 4.8 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 814 18 3 7 5.7 CCCCCCCC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
10032981 106808 None 0 Rabbit Functional pKd = 4.8 4.8 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
CHEMBL3144347 106808 None 0 Rabbit Functional pKd = 4.8 4.8 - 0
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 746 12 3 8 3.3 COC(=O)n1cc(C[C@@H](NC(=O)C[C@@H]2NC(=O)[C@@H]3C4CCC(CC4)N3C2=O)C(=O)N[C@@H](Cc2ccccc2)C(=O)N(C)Cc2ccccc2)c2ccccc21 10.1021/jm00063a015
9832198 106811 None 0 Rabbit Functional pKd = 4.8 4.8 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106811 None 0 Rabbit Functional pKd = 4.8 4.8 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL385603 214817 None 0 Rabbit Functional pKd = 5.8 5.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL439287 216293 None 0 Rabbit Functional pKd = 5.8 5.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)O 10.1021/jm00014a022
CHEMBL268563 213218 None 0 Rabbit Functional pKd = 5.8 5.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL268563 213218 None 0 Golden hamster Functional pKd = 5.8 5.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL412621 215470 None 0 Golden hamster Functional pKd = 5.8 5.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL263743 213047 None 0 Golden hamster Functional pKd = 4.8 4.8 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None None 10.1021/jm00014a022
44347002 112897 None 0 Golden hamster Functional pKd = 7.7 7.7 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL330810 112897 None 0 Golden hamster Functional pKd = 7.7 7.7 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL438716 216249 None 0 Rat Functional pKd = 4.7 4.7 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
9874206 206229 None 0 Guinea pig Functional pKd = 7.7 7.7 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 206229 None 0 Guinea pig Functional pKd = 7.7 7.7 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL412621 215470 None 0 Rat Functional pKd = 6.7 6.7 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm00014a022
CHEMBL263997 213060 None 0 Rabbit Functional pKd = 6.7 6.7 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL441181 216342 None 0 Rat Functional pKd = 5.7 5.7 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL438716 216249 None 0 Rabbit Functional pKd = 4.7 4.7 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
57391133 68389 None 0 Human Functional pKd = 6.7 6.7 - 0
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68389 None 0 Human Functional pKd = 6.7 6.7 - 0
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
44370713 51047 None 0 Rat Functional pKd = 6.7 6.7 - 0
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
CHEMBL157858 51047 None 0 Rat Functional pKd = 6.7 6.7 - 0
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 653 13 4 7 3.2 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)NC(Cc1ccccc1)C(=O)N(C)C(C)c1ccccc1)C(C)O 10.1021/jm960213s
10055415 106812 None 0 Rabbit Functional pKd = 5.7 5.7 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106812 None 0 Rabbit Functional pKd = 5.7 5.7 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
3086681 2272 None 18 Rabbit Functional pKd = 4.7 4.7 - 1
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
3510 2272 None 18 Rabbit Functional pKd = 4.7 4.7 - 1
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
CHEMBL42407 2272 None 18 Rabbit Functional pKd = 4.7 4.7 - 1
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C(=O)C)C[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)CN1CCC(CC1)N1CCCCC1 10.1021/jm950616c
10325464 120198 None 0 Rabbit Functional pKd = 4.7 4.7 - 1
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL351236 120198 None 0 Rabbit Functional pKd = 4.7 4.7 - 1
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 559 11 2 5 4.2 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCC(N2CCCCC2)CC1)C(C)=O 10.1021/jm950616c
10506928 120282 None 0 Rabbit Functional pKd = 4.7 4.7 - 1
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
CHEMBL352102 120282 None 0 Rabbit Functional pKd = 4.7 4.7 - 1
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 553 11 2 5 4.1 COc1ccccc1CN(C[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN1CCN(c2ccccc2)CC1)C(C)=O 10.1021/jm950616c
10350454 106787 None 0 Rabbit Functional pKd = 4.7 4.7 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106787 None 0 Rabbit Functional pKd = 4.7 4.7 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44347001 113247 None 0 Golden hamster Functional pKd = 8.7 8.7 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL331480 113247 None 0 Golden hamster Functional pKd = 8.7 8.7 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374556 52747 None 0 Rabbit Functional pKd = 8.6 8.6 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159449 52747 None 0 Rabbit Functional pKd = 8.6 8.6 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44392444 122400 None 0 Rabbit Functional pKd = 8.6 8.6 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359903 122400 None 0 Rabbit Functional pKd = 8.6 8.6 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL429340 215983 None 0 Rabbit Functional pKd = 7.7 7.7 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL263997 213060 None 0 Rat Functional pKd = 6.7 6.7 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44347083 15460 None 0 Rabbit Functional pKd = 6.7 6.7 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL121571 15460 None 0 Rabbit Functional pKd = 6.7 6.7 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 762 12 8 8 1.4 CSCC[C@@H]1NC[C@@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC1=O 10.1021/jm00047a020
CHEMBL334721 213858 None 1 Guinea pig Functional pKd = 7.6 7.6 - 2
Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig tracheaCompound was evaluated for antagonistic activity towards Tachykinin receptor 2 at guinea pig trachea
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00282-0
CHEMBL263985 213059 None 0 Rat Functional pKd = 5.6 5.6 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
9918520 102806 None 0 Guinea pig Functional pKd = 7.6 7.6 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 102806 None 0 Guinea pig Functional pKd = 7.6 7.6 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL429340 215983 None 0 Rat Functional pKd = 6.6 6.6 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL217365 211833 None 0 Rat Functional pKd = 4.6 4.6 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL266526 213145 None 0 Rabbit Functional pKd = 6.6 6.6 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL412830 215491 None 0 Rabbit Functional pKd = 5.6 5.6 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412189 215435 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL385914 214829 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
71449112 78930 None 0 Rabbit Functional pKd = 8.5 8.5 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112926 78930 None 0 Rabbit Functional pKd = 8.5 8.5 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374557 119659 None 0 Rabbit Functional pKd = 8.5 8.5 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
CHEMBL346285 119659 None 0 Rabbit Functional pKd = 8.5 8.5 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
9807403 66705 None 0 Rabbit Functional pKd = 8.5 8.5 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185452 66705 None 0 Rabbit Functional pKd = 8.5 8.5 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44346707 114559 None 0 Golden hamster Functional pKd = 8.4 8.4 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333515 114559 None 0 Golden hamster Functional pKd = 8.4 8.4 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 7 7 3.0 CC(C)C[C@@H]1CN(C)[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44370529 49073 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
CHEMBL156128 49073 None 0 Rat Functional pKd = 8.4 8.4 - 0
Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)Antagonistic activity against Tachykinin receptor 2 was determined in the rat colon muscularis mucosae (RC)
ChEMBL 643 10 3 7 3.0 CC(=O)NC(C(=O)N[C@H](Cc1cc2ccccc2n1C(C)=O)C(=O)N1C(C(=O)N(C)Cc2ccccc2)CC2CCCCC21)C(C)O 10.1021/jm960213s
10305816 4220 None 1 Human Functional pKd = 8.4 8.4 - 0
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100298 4220 None 1 Human Functional pKd = 8.4 8.4 - 0
Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2Functional affinity was evaluated by measuring the intracellular calcium concentration in CHO cells transfected with the human Tachykinin receptor 2 using Fura-2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44374543 52911 None 0 Rabbit Functional pKd = 8.4 8.4 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159585 52911 None 0 Rabbit Functional pKd = 8.4 8.4 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374598 119555 None 0 Rabbit Functional pKd = 8.4 8.4 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL345402 119555 None 0 Rabbit Functional pKd = 8.4 8.4 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL412830 215491 None 0 Rat Functional pKd = 7.5 7.5 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
44346486 114187 None 0 Golden hamster Functional pKd = 6.5 6.5 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 759 13 9 8 0.8 CC(C)C[C@@H]1CN[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332820 114187 None 0 Golden hamster Functional pKd = 6.5 6.5 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 759 13 9 8 0.8 CC(C)C[C@@H]1CN[C@@H](CCCCN)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346488 164283 None 0 Golden hamster Functional pKd = 7.5 7.5 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
CHEMBL421071 164283 None 0 Golden hamster Functional pKd = 7.5 7.5 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 798 11 8 7 2.2 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC2CCCCC2)NC1=O 10.1021/jm00047a020
10145229 9175 None 0 Golden hamster Functional pKd = 6.5 6.5 - 0
Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9175 None 0 Golden hamster Functional pKd = 6.5 6.5 - 0
Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.Inhibition of NKA-induced airway contraction of isolated hamster trachea (ht) was used as a measure of NK2-receptor antagonist activity.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL263985 213059 None 0 Golden hamster Functional pKd = 4.5 4.5 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
44305816 163114 None 0 Rabbit Functional pKd = 4.5 4.5 - 0
Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL417572 163114 None 0 Rabbit Functional pKd = 4.5 4.5 - 0
Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 589 8 2 4 3.6 CN(Cc1ccccc1)C(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)C1C=[N+](C)c2ccccc21 10.1016/S0960-894X(96)00604-X
CHEMBL216897 211803 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL267409 213179 None 0 Rat Functional pKd = 7.5 7.5 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)O 10.1021/jm00014a022
CHEMBL407328 215114 None 0 Rat Functional pKd = 6.5 6.5 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL385914 214829 None 0 Golden hamster Functional pKd = 6.5 6.5 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
44346727 168271 None 0 Rabbit Functional pKd = 7.4 7.4 - 0
Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uMTested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433191 168271 None 0 Rabbit Functional pKd = 7.4 7.4 - 0
Tested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uMTested for agonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery at a concentration of 3-10 uM
ChEMBL 784 11 8 7 2.7 CC(C)C[C@@H]1CN[C@@H](CC2CCCCC2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL266526 213145 None 0 Rat Functional pKd = 6.4 6.4 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL387199 214867 None 0 Rat Functional pKd = 6.4 6.4 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44307819 102651 None 0 Guinea pig Functional pKd = 7.4 7.4 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102651 None 0 Guinea pig Functional pKd = 7.4 7.4 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307678 201131 None 0 Guinea pig Functional pKd = 7.4 7.4 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 201131 None 0 Guinea pig Functional pKd = 7.4 7.4 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307820 206093 None 0 Guinea pig Functional pKd = 7.4 7.4 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 206093 None 0 Guinea pig Functional pKd = 7.4 7.4 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
21121353 101528 None 0 Rabbit Functional pKd = 5.4 5.4 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101528 None 0 Rabbit Functional pKd = 5.4 5.4 - 4
Tested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonistTested for antagonist activity against NK-2 receptor in rabbit pulmonary artery by using Neurokinin A as agonist
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
44346863 166479 None 0 Golden hamster Functional pKd = 8.4 8.4 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL427606 166479 None 0 Golden hamster Functional pKd = 8.4 8.4 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 909 13 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL406487 215070 None 0 Rabbit Functional pKd = 6.4 6.4 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL262647 213002 None 0 Golden hamster Functional pKd = 5.4 5.4 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O 10.1021/jm00014a022
44346794 15274 None 0 Rabbit Functional pKd = 7.4 7.4 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL121271 15274 None 0 Rabbit Functional pKd = 7.4 7.4 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 828 11 8 7 3.1 CC(C)C[C@@H]1CN[C@@H](Cc2ccc3ccccc3c2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL412830 215491 None 0 Golden hamster Functional pKd = 6.4 6.4 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL263743 213047 None 0 Rat Functional pKd = 5.4 5.4 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None None 10.1021/jm00014a022
CHEMBL441181 216342 None 0 Rabbit Functional pKd = 5.3 5.3 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
9829402 168603 None 0 Rabbit Functional pKd = 8.3 8.3 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
CHEMBL435324 168603 None 0 Rabbit Functional pKd = 8.3 8.3 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
1488931 51576 None 12 Guinea pig Functional pKd = 7.3 7.3 - 0
Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig tracheaCompound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea
ChEMBL 344 2 0 6 3.8 O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12 10.1016/0960-894X(95)00558-B
CHEMBL158318 51576 None 12 Guinea pig Functional pKd = 7.3 7.3 - 0
Compound was evaluated for NK-2 receptor antagonistic activity in the guinea pig tracheaCompound was evaluated for NK-2 receptor antagonistic activity in the guinea pig trachea
ChEMBL 344 2 0 6 3.8 O=c1c2cnn(-c3ccccc3)c2nc2scc(-c3ccccc3)n12 10.1016/0960-894X(95)00558-B
9896563 103835 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 103835 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
9939307 205944 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 205944 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 205994 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 205994 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307758 206014 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 206014 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 206033 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 206033 None 0 Guinea pig Functional pKd = 7.3 7.3 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307741 206245 None 0 Guinea pig Functional pKd = 6.3 6.3 - 0
In vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstrictionIn vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 206245 None 0 Guinea pig Functional pKd = 6.3 6.3 - 0
In vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstrictionIn vivo NK2 activity is characterized by the compound ability to inhibit guinea pig bronchoconstriction
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
104943 55402 None 31 Rabbit Functional pKd = 4.3 4.3 - 5
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
CHEMBL16192 55402 None 31 Rabbit Functional pKd = 4.3 4.3 - 5
Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2
ChEMBL 412 7 1 3 5.1 COc1ccccc1CN[C@H]1C2CCN(CC2)[C@H]1C(c1ccccc1)c1ccccc1 10.1021/jm950616c
44347001 113247 None 0 Rabbit Functional pKd = 7.3 7.3 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL331480 113247 None 0 Rabbit Functional pKd = 7.3 7.3 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 851 15 9 9 2.0 CC(C)C[C@@H]1CN[C@@H](CCC(N)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
9939040 5012 None 7 Guinea pig Functional pKd = 7.3 7.3 - 2
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL105060 5012 None 7 Guinea pig Functional pKd = 7.3 7.3 - 2
In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2In vitro relative antagonist potency towards guinea pig Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL266526 213145 None 0 Golden hamster Functional pKd = 6.3 6.3 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL327457 213752 None 0 Rabbit Functional pKd = 5.2 5.2 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL334721 213858 None 1 Rat Functional pKd = 8.2 8.2 - 2
Compound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferensCompound was evaluated for antagonistic activity towards Tachykinin receptor 2 in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00282-0
44374504 54865 None 0 Rabbit Functional pKd = 8.2 8.2 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL161288 54865 None 0 Rabbit Functional pKd = 8.2 8.2 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
71461644 78928 None 0 Rabbit Functional pKd = 8.2 8.2 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL2112924 78928 None 0 Rabbit Functional pKd = 8.2 8.2 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
11038500 63574 None 0 Rabbit Functional pKd = 8.2 8.2 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL180049 63574 None 0 Rabbit Functional pKd = 8.2 8.2 - 1
pA2 for NK2 receptor of rabbit pulmonary arterypA2 for NK2 receptor of rabbit pulmonary artery
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44347084 114317 None 0 Golden hamster Functional pKd = 8.2 8.2 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL333027 114317 None 0 Golden hamster Functional pKd = 8.2 8.2 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 893 16 9 9 2.8 CC(C)C[C@@H]1CN[C@@H](CCCCNC(=O)OCc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
9875181 171446 None 0 Guinea pig Functional pKd = 7.2 7.2 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 171446 None 0 Guinea pig Functional pKd = 7.2 7.2 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
57391132 68388 None 0 Human Functional pKd = 6.2 6.2 - 0
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916634 68388 None 0 Human Functional pKd = 6.2 6.2 - 0
Antagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assayAntagonist activity at human NK2 receptor expressed in CHO cells assessed as inhibition of Neurokinin A-induced increase in intracellular Ca2+ increase by Fura-2 assay
ChEMBL 599 10 3 6 2.6 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(C)=O)C1 10.1016/j.ejmech.2011.08.042
44307953 169297 None 0 Guinea pig Functional pKd = 6.2 6.2 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 169297 None 0 Guinea pig Functional pKd = 6.2 6.2 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 169297 None 0 Guinea pig Functional pKd = 6.2 6.2 - 0
In vitro functional NK2 activity as inhibition of guinea pig bronchoconstrictionIn vitro functional NK2 activity as inhibition of guinea pig bronchoconstriction
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL438716 216249 None 0 Golden hamster Functional pKd = 5.2 5.2 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL216897 211803 None 0 Rabbit Functional pKd = 5.2 5.2 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
132837 2237 None 40 Rabbit Functional pKd = 5.2 5.2 - 4
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
9461 2237 None 40 Rabbit Functional pKd = 5.2 5.2 - 4
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL22870 2237 None 40 Rabbit Functional pKd = 5.2 5.2 - 4
Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.Antagonistic potency for NK-2 receptor was determined in vitro, using isolated rabbit pulmonary artery.
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1016/S0960-894X(96)00604-X
CHEMBL407328 215114 None 0 Rabbit Functional pKd = 7.2 7.2 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL263997 213060 None 0 Golden hamster Functional pKd = 6.2 6.2 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL441181 216342 None 0 Golden hamster Functional pKd = 5.2 5.2 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44346487 114194 None 0 Golden hamster Functional pKd = 7.2 7.2 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL332872 114194 None 0 Golden hamster Functional pKd = 7.2 7.2 - 0
Tested for antagonist activity at NK-2 tachykinin receptors in hamster tracheaTested for antagonist activity at NK-2 tachykinin receptors in hamster trachea
ChEMBL 746 11 9 8 0.2 CC(C)C[C@@H]1CN[C@@H](CC(=O)O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346706 168272 None 0 Rabbit Functional pKd = 6.2 6.2 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL433192 168272 None 0 Rabbit Functional pKd = 6.2 6.2 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 745 11 9 8 -0.4 CC(C)C[C@@H]1CN[C@@H](CC(N)=O)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44374622 120127 None 0 Rabbit Functional pKd = 8.1 8.1 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL350596 120127 None 0 Rabbit Functional pKd = 8.1 8.1 - 0
In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)In vitro functional activity towards Neurokinin NK2 receptor on isolated rabbit urinary bladder (RUB)
ChEMBL 825 11 10 10 -0.8 CC(=O)NC1C(NC(=O)C[C@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL327457 213752 None 0 Rat Functional pKd = 5.1 5.1 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL385603 214817 None 0 Rat Functional pKd = 7.1 7.1 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
44347002 112897 None 0 Rabbit Functional pKd = 7.1 7.1 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
CHEMBL330810 112897 None 0 Rabbit Functional pKd = 7.1 7.1 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 778 11 8 7 1.9 CC(C)C[C@@H]1CN[C@@H](Cc2ccccc2)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N1 10.1021/jm00047a020
44346881 141610 None 0 Rabbit Functional pKd = 5.1 5.1 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL384610 141610 None 0 Rabbit Functional pKd = 5.1 5.1 - 0
Antagonist activity at NK-2 tachykinin receptors in rabbit pulmonary arteryAntagonist activity at NK-2 tachykinin receptors in rabbit pulmonary artery
ChEMBL 923 13 9 9 1.5 CC(C)C[C@H]1NC(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CC(=O)N(N)C[C@]23C[C@H]4C[C@H](C[C@H](C4)C2)C3)NC1=O 10.1021/jm00047a020
CHEMBL406487 215070 None 0 Rat Functional pKd = 6.1 6.1 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None CC(C)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CCCN=C(N)N)C(=O)O 10.1021/jm00014a022
CHEMBL387199 214867 None 0 Rabbit Functional pKd = 7.1 7.1 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.Antagonist activity against Tachykinin receptor 2 was measured by Rabbit pulmonary artery(RPA) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/jm00014a022
CHEMBL327457 213752 None 0 Golden hamster Functional pKd = 5.0 5.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(=O)O 10.1021/jm00014a022
CHEMBL412189 215435 None 0 Golden hamster Functional pKd = 6.0 6.0 - 0
Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.Antagonist activity against Tachykinin receptor 2 was measured by Hamster isolated trachea(HT) assay.
ChEMBL None None None CC(C)[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)O 10.1021/jm00014a022
CHEMBL413730 215545 None 0 Rat Functional pKd = 5.0 5.0 - 0
Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)Antagonism against Tachykinin receptor 2 in rat vas deferens(RVD)
ChEMBL None None None None 10.1021/jm00014a022
44434204 153657 None 0 Guinea pig Functional pKi = 7 7.0 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL398028 153657 None 0 Guinea pig Functional pKi = 7 7.0 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
10166998 166776 None 0 Guinea pig Functional pKi = 7 7.0 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL428203 166776 None 0 Guinea pig Functional pKi = 7 7.0 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434205 89436 None 0 Guinea pig Functional pKi = 6.9 6.9 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237048 89436 None 0 Guinea pig Functional pKi = 6.9 6.9 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
44434197 149314 None 0 Guinea pig Functional pKi = 7.7 7.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 149314 None 0 Guinea pig Functional pKi = 7.7 7.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
10121831 89473 None 0 Guinea pig Functional pKi = 6.7 6.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237097 89473 None 0 Guinea pig Functional pKi = 6.7 6.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434203 149315 None 0 Guinea pig Functional pKi = 6.7 6.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394420 149315 None 0 Guinea pig Functional pKi = 6.7 6.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434191 149924 None 0 Guinea pig Functional pKi = 6.7 6.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL394889 149924 None 0 Guinea pig Functional pKi = 6.7 6.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434202 152259 None 0 Guinea pig Functional pKi = 6.7 6.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL396827 152259 None 0 Guinea pig Functional pKi = 6.7 6.7 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
10281234 92268 None 0 Guinea pig Functional pKi = 7.6 7.6 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL242631 92268 None 0 Guinea pig Functional pKi = 7.6 7.6 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434198 149911 None 0 Guinea pig Functional pKi = 7.6 7.6 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL394878 149911 None 0 Guinea pig Functional pKi = 7.6 7.6 - 0
Agonist activity at NK2 receptor in guinea pig smooth muscleAgonist activity at NK2 receptor in guinea pig smooth muscle
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
3881 1854 None 0 Rat Functional pEC50 = 8.4 8.4 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1331460
2091 2795 None 0 Guinea pig Functional pEC50 = 8.8 8.8 223 2
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
2089 2766 None 25 Guinea pig Functional pEC50 = 8.9 8.9 -1 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
3795 2766 None 25 Guinea pig Functional pEC50 = 8.9 8.9 -1 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
5311311 2766 None 25 Guinea pig Functional pEC50 = 8.9 8.9 -1 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
CHEMBL217406 2766 None 25 Guinea pig Functional pEC50 = 8.9 8.9 -1 8
UnclassifiedUnclassified
Guide to Pharmacology None None None None 2426129
16132172 2792 None 0 Guinea pig Functional pEC50 = 9.5 9.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
3667 2792 None 0 Guinea pig Functional pEC50 = 9.5 9.5 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1311427
30699 220190 None 0 Human Functional pIC50 = 8.3 8.3 -1 14
NoneNone
Drug Central 423 7 2 8 0.5 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSC1=CC=NC=C1)C2=O)C(O)=O None
104974 3475 None 25 Guinea pig Functional pIC50 = 10.3 10.3 6 5
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
2111 3475 None 25 Guinea pig Functional pIC50 = 10.3 10.3 6 5
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
3481 3475 None 25 Guinea pig Functional pIC50 = 10.3 10.3 6 5
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
CHEMBL308148 3475 None 25 Guinea pig Functional pIC50 = 10.3 10.3 6 5
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
DB06660 3475 None 25 Guinea pig Functional pIC50 = 10.3 10.3 6 5
UnclassifiedUnclassified
Guide to Pharmacology 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 1334836
3843 2437 None 0 Rat Functional pIC50 = 9.1 9.1 - 1
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9718274


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Ligands (move mouse cursor over ligand name to see structure) Receptor Activity Chemical information
Sel. page Common
name		 GPCRdb
ID		 Reference
ligand		 Vendors

 Species

 Assay
Type		 Activity
Type		 Activity
Relation		 Activity
Value		 p-value
(-log)		 Fold
selectivity		 Tested
GPCRs		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
1024 1289 None 44 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
162639143 1289 None 44 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
5284373 1289 None 44 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
760 1289 None 44 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL160 1289 None 44 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
DB00091 1289 None 44 Human Binding pAC50 = 4.9 4.9 - 1
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
2018 3007 None 26 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
9941444 3007 None 26 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
CHEMBL3349607 3007 None 26 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
DB06663 3007 None 26 Human Binding pAC50 = 4.9 4.9 - 4
Binding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtrationBinding affinity towards human TACR2 in an in vitro assay with cellular components measured by membrane filtration
ChEMBL None None None None 10.1038/s41467-023-40064-9
124003 2486 None 22 Human Binding pEC50 = 7.1 7.1 - 1
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
2116 2486 None 22 Human Binding pEC50 = 7.1 7.1 - 1
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL507824 2486 None 22 Human Binding pEC50 = 7.1 7.1 - 1
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in CHO cells
ChEMBL None None None None 10.1021/np058114h
CHEMBL334721 213858 None 1 Golden hamster Binding pIC50 = 10.1 10.1 - 3
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/S0960-894X(96)00570-7
104974 3475 None 25 Human Binding pIC50 = 9.9 9.9 1 7
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
2111 3475 None 25 Human Binding pIC50 = 9.9 9.9 1 7
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
3481 3475 None 25 Human Binding pIC50 = 9.9 9.9 1 7
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
CHEMBL308148 3475 None 25 Human Binding pIC50 = 9.9 9.9 1 7
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
DB06660 3475 None 25 Human Binding pIC50 = 9.9 9.9 1 7
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(98)00395-3
68932311 124860 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642170 124860 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 565 5 1 4 4.3 CN(C(=O)c1ccc(Cl)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68870199 124861 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642171 124861 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 535 5 0 3 5.8 CC(=O)N1CCC(CN2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68932793 124863 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642173 124863 None 0 Human Binding pIC50 = 9.7 9.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 599 5 1 4 4.7 CN(C(=O)c1ccc(C(F)(F)F)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68930433 124856 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642166 124856 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 583 4 0 3 5.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C(F)(F)F)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68928720 124864 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642174 124864 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 609 5 1 4 4.4 CN(C(=O)c1ccc(Br)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68870858 124858 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642168 124858 None 0 Human Binding pIC50 = 9.6 9.6 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 555 5 0 3 5.6 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C4CC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68870105 124854 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642164 124854 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
68932418 124862 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 642 6 1 6 4.1 CN(C(=O)c1ccc(N2CCOCC2)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3(O)CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642172 124862 None 0 Human Binding pIC50 = 9.5 9.5 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 642 6 1 6 4.1 CN(C(=O)c1ccc(N2CCOCC2)cc1)[C@@H]1CCN(C(=O)C2CCN(C(=O)C3(O)CC3)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
68928842 124865 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
CHEMBL3642175 124865 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 1 5 4.1 CN(C(=O)c1ccc(C(F)(F)F)cn1)[C@@H]1CCN(C(=O)C2CCN(C(=O)CO)CC2)C[C@H]1c1ccc(Cl)c(Cl)c1 nan
9959481 65240 None 0 Human Binding pIC50 = 9.4 9.4 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL182600 65240 None 0 Human Binding pIC50 = 9.4 9.4 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 559 7 0 3 6.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
68869786 124857 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 0 5 4.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(N4CCOCC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642167 124857 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 600 5 0 5 4.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(N4CCOCC4)cc3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
104974 3475 None 25 Human Binding pIC50 = 9.4 9.4 1 7
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
2111 3475 None 25 Human Binding pIC50 = 9.4 9.4 1 7
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
3481 3475 None 25 Human Binding pIC50 = 9.4 9.4 1 7
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
CHEMBL308148 3475 None 25 Human Binding pIC50 = 9.4 9.4 1 7
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
DB06660 3475 None 25 Human Binding pIC50 = 9.4 9.4 1 7
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00148-5
71699787 124847 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642157 124847 None 0 Human Binding pIC50 = 9.4 9.4 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 593 4 0 3 5.5 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
693306 160523 None 41 Human Binding pIC50 = 9.3 9.3 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 290 6 0 3 4.1 CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1 nan
CHEMBL4111499 160523 None 41 Human Binding pIC50 = 9.3 9.3 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 290 6 0 3 4.1 CCOc1cc(C=O)ccc1OCc1ccc(Cl)cc1 nan
68932391 124855 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642165 124855 None 0 Human Binding pIC50 = 9.3 9.3 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)C[C@H]2c2ccc(Cl)c(Cl)c2)cc1 nan
42611207 124853 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642163 124853 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 651 4 0 3 6.7 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
10929285 66730 None 0 Human Binding pIC50 = 9.1 9.1 - 2
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL185572 66730 None 0 Human Binding pIC50 = 9.1 9.1 - 2
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 7 0 4 4.8 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCCCC1 10.1016/j.bmcl.2005.05.134
104974 3475 None 25 Human Binding pIC50 = 9.1 9.1 1 7
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
2111 3475 None 25 Human Binding pIC50 = 9.1 9.1 1 7
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
3481 3475 None 25 Human Binding pIC50 = 9.1 9.1 1 7
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
CHEMBL308148 3475 None 25 Human Binding pIC50 = 9.1 9.1 1 7
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
DB06660 3475 None 25 Human Binding pIC50 = 9.1 9.1 1 7
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/0960-894X(96)00075-3
68932301 124859 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642169 124859 None 0 Human Binding pIC50 = 9.1 9.1 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 594 4 0 4 4.9 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Br)cn3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
2089 2766 None 25 Golden hamster Binding pIC50 = 9 9.0 - 5
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3795 2766 None 25 Golden hamster Binding pIC50 = 9 9.0 - 5
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
5311311 2766 None 25 Golden hamster Binding pIC50 = 9 9.0 - 5
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL217406 2766 None 25 Golden hamster Binding pIC50 = 9 9.0 - 5
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
10033398 117356 None 0 Golden hamster Binding pIC50 = 9 9.0 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 824 27 9 10 -0.0 CCCN(C[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a024
CHEMBL339591 117356 None 0 Golden hamster Binding pIC50 = 9 9.0 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 824 27 9 10 -0.0 CCCN(C[C@H](CC(C)C)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](Cc1ccccc1)C(N)=O 10.1021/jm00099a024
44392491 168413 None 0 Human Binding pIC50 = 9 9.0 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434142 168413 None 0 Human Binding pIC50 = 9 9.0 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 556 7 1 4 5.2 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
71699790 124850 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642160 124850 None 0 Human Binding pIC50 = 9.0 9.0 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 549 4 0 3 5.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(Cl)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
72548703 161661 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 161661 None 0 Human Binding pIC50 = 8.9 8.9 - 0
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
44392351 66423 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185182 66423 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 620 8 0 5 4.3 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392439 168478 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL434548 168478 None 0 Human Binding pIC50 = 8.9 8.9 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 557 7 1 4 5.2 O=C1CC[C@](CCN2CC(N3CCC(O)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
2089 2766 None 25 Human Binding pIC50 = 8.8 8.8 102 5
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3795 2766 None 25 Human Binding pIC50 = 8.8 8.8 102 5
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311311 2766 None 25 Human Binding pIC50 = 8.8 8.8 102 5
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL217406 2766 None 25 Human Binding pIC50 = 8.8 8.8 102 5
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
71699791 124851 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642161 124851 None 0 Human Binding pIC50 = 8.8 8.8 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 591 5 0 3 6.4 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(-c4ccccc4)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
10327914 18098 None 0 Golden hamster Binding pIC50 = 8 8.0 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 782 25 10 10 -1.1 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL126776 18098 None 0 Golden hamster Binding pIC50 = 8 8.0 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 782 25 10 10 -1.1 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
44392444 122400 None 0 Human Binding pIC50 = 8 8.0 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359903 122400 None 0 Human Binding pIC50 = 8 8.0 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 481 7 0 3 4.8 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
44319321 13709 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194933 13709 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553554 13709 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265452 126513 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651890 126513 None 0 Human Binding pIC50 = 7 7.0 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 609 4 0 4 5.8 CN(C(=O)N(C)[C@@H]1CCN(C2CCS(=O)(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
91535935 158711 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 532 7 1 4 6.8 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL4092276 158711 None 0 Human Binding pIC50 = 7 7.0 - 0
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 532 7 1 4 6.8 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
44411742 78334 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
CHEMBL210811 78334 None 0 Human Binding pIC50 = 6 6.0 - 0
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccc(F)cc1 10.1016/j.bmcl.2006.02.027
2812 4781 None 63 Human Binding pIC50 = 5.0 5.0 -28 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4781 None 63 Human Binding pIC50 = 5.0 5.0 -28 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
2090 2767 None 27 Human Binding pIC50 = 7.0 7.0 -38 4
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311312 2767 None 27 Human Binding pIC50 = 7.0 7.0 -38 4
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL437797 2767 None 27 Human Binding pIC50 = 7.0 7.0 -38 4
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10010429 19049 None 0 Golden hamster Binding pIC50 = 7.0 7.0 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 776 26 9 10 -0.6 CCCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL128854 19049 None 0 Golden hamster Binding pIC50 = 7.0 7.0 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 776 26 9 10 -0.6 CCCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
49863734 15339 None 0 Rat Binding pIC50 = 7.0 7.0 -13 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15339 None 0 Rat Binding pIC50 = 7.0 7.0 -13 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL103634 210917 None 0 Human Binding pIC50 = 7.0 7.0 - 1
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44305248 205345 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL62679 205345 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 585 8 1 3 7.0 CN(C)CCCNC(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
10485206 118241 None 0 Golden hamster Binding pIC50 = 7.0 7.0 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 25 10 10 -1.3 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL340880 118241 None 0 Golden hamster Binding pIC50 = 7.0 7.0 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 25 10 10 -1.3 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CCNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
44384901 170007 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
CHEMBL444086 170007 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1 10.1016/0960-894X(96)00148-5
44319082 168130 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL432183 168130 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 752 13 1 8 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)NCCN4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL2372521 212728 None 0 Rat Binding pIC50 = 7.0 7.0 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2ccccc21)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
10435115 120863 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 476 7 2 3 5.2 [O-][S+](c1ccccc1)C(c1ccccc1)C1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL355541 120863 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 476 7 2 3 5.2 [O-][S+](c1ccccc1)C(c1ccccc1)C1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
9940218 118402 None 2 Golden hamster Binding pIC50 = 6.9 6.9 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL341015 118402 None 2 Golden hamster Binding pIC50 = 6.9 6.9 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@@H](CN[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
67232184 126514 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651891 126514 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 548 4 0 3 4.9 CC(=O)N1CCC(C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(Cl)cc(Cl)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44384902 59967 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL173245 59967 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1cccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44319222 106199 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313546 106199 None 0 Mouse Binding pIC50 = 7.9 7.9 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 657 10 1 6 5.9 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccc(F)cc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265453 126515 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651892 126515 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 617 4 0 4 5.0 CC(=O)N1CCC(C(=O)N2CC(c3ccc(F)cn3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL2372519 212727 None 0 Rat Binding pIC50 = 6.9 6.9 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1CCc2cc3ccccc3cc21)C(N)=O 10.1021/jm00037a009
71458131 79715 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2115343 79715 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
71452663 78573 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2112070 78573 None 0 Human Binding pIC50 = 6.9 6.9 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
2750 206519 None 50 Human Binding pIC50 = 4.9 4.9 -2 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
CHEMBL7002 206519 None 50 Human Binding pIC50 = 4.9 4.9 -2 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
9832198 106811 None 0 Human Binding pIC50 = 6.9 6.9 - 3
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106811 None 0 Human Binding pIC50 = 6.9 6.9 - 3
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384986 129842 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
CHEMBL367528 129842 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 623 9 1 5 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1C 10.1016/0960-894X(96)00148-5
10366515 57595 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 450 6 2 3 4.6 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1016/s0960-894x(01)00074-9
CHEMBL166675 57595 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 450 6 2 3 4.6 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccc2ccccc2c1 10.1016/s0960-894x(01)00074-9
CHEMBL2372516 212724 None 0 Rat Binding pIC50 = 5.9 5.9 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
137647980 158029 None 5 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 600 7 1 4 7.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL4084542 158029 None 5 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of NK2 receptor (unknown origin) by FLIPR assayInhibition of NK2 receptor (unknown origin) by FLIPR assay
ChEMBL 600 7 1 4 7.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2cccc(C(F)(F)F)c2)nc2ccccc12)c1ccccc1 10.1021/acsmedchemlett.7b00094
CHEMBL341065 214098 None 0 Golden hamster Binding pIC50 = 6.9 6.9 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL449091 216422 None 0 Golden hamster Binding pIC50 = 5.9 5.9 - 0
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44312324 207142 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73896 207142 None 0 Human Binding pIC50 = 6.9 6.9 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 534 7 2 2 5.8 CCN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44312219 102436 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL303868 102436 None 0 Human Binding pIC50 = 7.9 7.9 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 506 6 3 2 5.1 O=C(NCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
44380176 161603 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 613 10 1 3 7.7 CN(C[C@@H](CCN1CCC(NC(=O)c2ccccc2)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL412815 161603 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 613 10 1 3 7.7 CN(C[C@@H](CCN1CCC(NC(=O)c2ccccc2)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(01)00074-9
44312056 207181 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL74237 207181 None 0 Human Binding pIC50 = 5.9 5.9 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 595 7 2 4 6.2 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C)cc(C)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
10349900 106805 None 0 Rat Binding pIC50 = 6.9 6.9 - 3
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106805 None 0 Rat Binding pIC50 = 6.9 6.9 - 3
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
6518171 168399 None 38 Human Binding pIC50 = 4.8 4.8 -4 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
CHEMBL434063 168399 None 38 Human Binding pIC50 = 4.8 4.8 -4 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
3561 19084 None 29 Human Binding pIC50 = 5.8 5.8 -1 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
CHEMBL1289 19084 None 29 Human Binding pIC50 = 5.8 5.8 -1 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
2098 3694 None 31 Golden hamster Binding pIC50 = 6.8 6.8 - 6
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
36511 3694 None 31 Golden hamster Binding pIC50 = 6.8 6.8 - 6
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3805 3694 None 31 Golden hamster Binding pIC50 = 6.8 6.8 - 6
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
3835 3694 None 31 Golden hamster Binding pIC50 = 6.8 6.8 - 6
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL235363 3694 None 31 Golden hamster Binding pIC50 = 6.8 6.8 - 6
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
11038500 63574 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL180049 63574 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 507 9 0 4 4.8 CCOC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
10940813 66352 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185007 66352 None 0 Human Binding pIC50 = 7.8 7.8 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 571 9 0 5 2.8 CN(C)S(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
9914897 179164 None 0 Golden hamster Binding pIC50 = 5.8 5.8 - 0
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL47146 179164 None 0 Golden hamster Binding pIC50 = 5.8 5.8 - 0
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
9914897 179164 None 0 Golden hamster Binding pIC50 = 5.8 5.8 - 0
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL47146 179164 None 0 Golden hamster Binding pIC50 = 5.8 5.8 - 0
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 528 15 4 4 5.0 CC(C)[C@H](OC(=O)N[C@](C)(Cc1ccccc1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
148124 209557 None 54 Human Binding pIC50 = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL3545252 209557 None 54 Human Binding pIC50 = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL92 209557 None 54 Human Binding pIC50 = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
44319307 106603 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL314119 106603 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319306 107153 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315923 107153 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccncc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44212282 61307 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL176682 61307 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 579 8 1 4 5.7 COc1ccccc1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL276294 213287 None 0 Rat Binding pIC50 = 6.8 6.8 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)S(C)(=O)=O)C(N)=O 10.1021/jm00037a009
138106918 197942 None 30 Human Binding pIC50 = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
5311497 197942 None 30 Human Binding pIC50 = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
CHEMBL553025 197942 None 30 Human Binding pIC50 = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
6918276 15618 None 4 Human Binding pIC50 = 5.8 5.8 -56 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL1221512 15618 None 4 Human Binding pIC50 = 5.8 5.8 -56 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL306072 213436 None 0 Golden hamster Binding pIC50 = 5.8 5.8 - 0
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
71456198 78606 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL2112209 78606 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 565 8 2 6 4.7 COc1cc(C(=O)N(C)c2cc(C(=O)N[C@@H]3CCCCNC3=O)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
44351724 19404 None 0 Golden hamster Binding pIC50 = 6.8 6.8 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 818 26 9 10 -0.4 CC(C)CC(=O)N(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL129301 19404 None 0 Golden hamster Binding pIC50 = 6.8 6.8 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 818 26 9 10 -0.4 CC(C)CC(=O)N(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL340847 214095 None 0 Golden hamster Binding pIC50 = 5.8 5.8 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NCCCC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44312218 206598 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL70461 206598 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 542 8 1 4 5.5 CSN1CC2(CCN(C(=O)N[C@@H](CCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
11057 176253 None 16 Human Binding pIC50 = 5.8 5.8 -1 20
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 176253 None 16 Human Binding pIC50 = 5.8 5.8 -1 20
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 176253 None 16 Human Binding pIC50 = 5.8 5.8 -1 20
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 176253 None 16 Human Binding pIC50 = 5.8 5.8 -1 20
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
44305511 205424 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63014 205424 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 566 5 1 2 7.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
44335354 4936 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
CHEMBL104708 4936 None 0 Human Binding pIC50 = 7.8 7.8 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 629 7 2 4 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Cl)c(Cl)s1 10.1016/s0960-894x(01)00631-x
10349900 106805 None 0 Human Binding pIC50 = 7.8 7.8 - 3
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144343 106805 None 0 Human Binding pIC50 = 7.8 7.8 - 3
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 716 13 3 7 2.8 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C=O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44319223 107161 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
CHEMBL315982 107161 None 0 Mouse Binding pIC50 = 7.8 7.8 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 669 11 1 7 5.7 COc1cccc(C2(C(N)=O)CCN(CCC3(c4ccc(Cl)c(Cl)c4)CCN(C(=O)c4cc(OC)c(OC)c(OC)c4)C3)CC2)c1 10.1016/S0960-894X(97)10013-0
22901331 11985 None 0 Rat Binding pIC50 = 5.8 5.8 - 1
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
54435601 11985 None 0 Rat Binding pIC50 = 5.8 5.8 - 1
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
59922977 11985 None 0 Rat Binding pIC50 = 5.8 5.8 - 1
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL1183068 11985 None 0 Rat Binding pIC50 = 5.8 5.8 - 1
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL278294 11985 None 0 Rat Binding pIC50 = 5.8 5.8 - 1
Binding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenumBinding affinity of compound was evaluated towards tachykinin receptor 2 by using radioligand ([125I]-NKA in rat duodenum
ChEMBL 424 4 0 4 5.2 CCn1c(/C=C/C=C2\N(C)c3ccccc3C2(C)C)[n+](CC)c2nc3ccccc3nc21 10.1021/jm00109a034
CHEMBL406812 215081 None 0 Rat Binding pIC50 = 5.8 5.8 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
3823 50235 None 31 Human Binding pIC50 = 4.8 4.8 -36 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
76973198 50235 None 31 Human Binding pIC50 = 4.8 4.8 -36 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL157101 50235 None 31 Human Binding pIC50 = 4.8 4.8 -36 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
44444681 94426 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
CHEMBL250798 94426 None 0 Human Binding pIC50 = 5.8 5.8 - 0
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL 501 5 0 3 6.7 C[C@@H](O[C@@H]1CN(C2=CC(=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1016/j.bmcl.2007.06.085
15730 71142 None 57 Human Binding pIC50 = 4.8 4.8 -2 10
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
CHEMBL195437 71142 None 57 Human Binding pIC50 = 4.8 4.8 -2 10
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
10258592 99261 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL281481 99261 None 0 Human Binding pIC50 = 6.8 6.8 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 7 0 4 6.8 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCCN(C(=O)c4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
2090 2767 None 27 Golden hamster Binding pIC50 = 7.8 7.8 - 4
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
5311312 2767 None 27 Golden hamster Binding pIC50 = 7.8 7.8 - 4
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
CHEMBL437797 2767 None 27 Golden hamster Binding pIC50 = 7.8 7.8 - 4
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm00099a024
15391369 102883 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL305509 102883 None 0 Human Binding pIC50 = 7.8 7.8 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 518 6 2 2 5.5 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(C=Cc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
49863732 15337 None 0 Rat Binding pIC50 = 7.7 7.7 -24 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15337 None 0 Rat Binding pIC50 = 7.7 7.7 -24 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
9874168 208162 None 3 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL82386 208162 None 3 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL2372525 212729 None 0 Rat Binding pIC50 = 4.8 4.8 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
71452678 78608 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2112211 78608 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 591 5 2 3 6.4 Cc1ccc(-c2ccc(C(=O)N[C@@H]3CCCCNC3=O)cc2N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)cc1 10.1016/s0960-894x(02)00382-7
10350454 106787 None 0 Rat Binding pIC50 = 6.7 6.7 - 3
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106787 None 0 Rat Binding pIC50 = 6.7 6.7 - 3
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44384987 61374 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL176769 61374 None 0 Human Binding pIC50 = 7.7 7.7 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cc(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44335466 5056 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL105295 5056 None 0 Human Binding pIC50 = 7.7 7.7 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 720 8 2 5 6.0 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
44319057 208302 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL83585 208302 None 0 Mouse Binding pIC50 = 6.7 6.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3cccc(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL415600 215654 None 0 Rat Binding pIC50 = 5.7 5.7 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
2335 11852 None 18 Human Binding pIC50 = 5.7 5.7 -3 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
8478 11852 None 18 Human Binding pIC50 = 5.7 5.7 -3 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL1182210 11852 None 18 Human Binding pIC50 = 5.7 5.7 -3 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
CHEMBL221753 11852 None 18 Human Binding pIC50 = 5.7 5.7 -3 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 nan
10395276 18926 None 0 Golden hamster Binding pIC50 = 6.7 6.7 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 24 9 10 -1.4 CC(C)C[C@@H](CN(C)[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL128521 18926 None 0 Golden hamster Binding pIC50 = 6.7 6.7 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 748 24 9 10 -1.4 CC(C)C[C@@H](CN(C)[C@@H](CC(C)C)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
176 398 None 47 Human Binding pIC50 = 4.7 4.7 -4 31
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157 398 None 47 Human Binding pIC50 = 4.7 4.7 -4 31
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2157.0 398 None 47 Human Binding pIC50 = 4.7 4.7 -4 31
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
2566 398 None 47 Human Binding pIC50 = 4.7 4.7 -4 31
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
CHEMBL633 398 None 47 Human Binding pIC50 = 4.7 4.7 -4 31
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
DB01118 398 None 47 Human Binding pIC50 = 4.7 4.7 -4 31
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 645 11 0 4 6.9 CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2 nan
3191 102913 None 65 Human Binding pIC50 = 5.7 5.7 -12 25
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
3191.0 102913 None 65 Human Binding pIC50 = 5.7 5.7 -12 25
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL305660 102913 None 65 Human Binding pIC50 = 5.7 5.7 -12 25
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
DB11742 102913 None 65 Human Binding pIC50 = 5.7 5.7 -12 25
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 469 9 0 3 7.2 CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1 nan
CHEMBL36402 214381 None 0 Golden hamster Binding pIC50 = 4.7 4.7 - 0
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)O 10.1016/0960-894X(95)00254-Q
73265451 126512 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651889 126512 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 666 4 0 3 6.8 CC(=O)N1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
71699789 124849 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3642159 124849 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 529 4 0 3 5.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)c3ccc(C)cc3)C(c3ccc(Cl)c(Cl)c3)C2)CC1 nan
9853506 13094 None 0 Mouse Binding pIC50 = 8.7 8.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1190281 13094 None 0 Mouse Binding pIC50 = 8.7 8.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL540553 13094 None 0 Mouse Binding pIC50 = 8.7 8.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44319086 13717 None 0 Mouse Binding pIC50 = 8.7 8.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194977 13717 None 0 Mouse Binding pIC50 = 8.7 8.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553617 13717 None 0 Mouse Binding pIC50 = 8.7 8.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9852376 99156 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
CHEMBL280789 99156 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 639 8 0 4 6.6 CS(=O)(=O)N1CC2(CCN(CCCC3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(Cc4ccccc4)C3)CC2)c2ccccc21 10.1016/s0960-894x(98)00215-7
71699792 124852 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3642162 124852 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 636 5 0 3 7.5 CC(=O)C1CCC(C(=O)N2CC(c3ccc(Cl)c(Cl)c3)[C@H](N(C)C(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
44404006 132824 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
CHEMBL370013 132824 None 0 Human Binding pIC50 = 8.7 8.7 - 0
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CC[C@@]2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1021/jm058225d
71699788 124848 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
CHEMBL3642158 124848 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.Human NK1 Receptor Binding Assay: IM-9 cells (2×10^5 cells/mL) were cultured for 3 days after inoculation, and centrifuged at 500×g for 10 min to give cell pellets. The obtained pellets were washed with PBS (Phosphate-Buffered saline) (GIBCO), disrupted in buffer A (50 mM Tris-hydrochloric acid buffer (Tris-HCl) (pH 7.4) containing 120 mM sodium chloride, 5 mM potassium chloride, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and 1 mM ethylenediaminetetraacetic acid (EDTA)) using a Polytron homogenizer (Kinematika, Germany), and centrifuged at 100,000×g for 40 min. The precipitation fraction was suspended in buffer B (50 mM Tris-HCl (pH 7.4), 0.02% bovine serum albumin, 2 μg/mL chymostatin, 40 μg/mL bacitracin, 40 μg/mL APMSF, 3 mM manganese dichloride (MnCl2)) and cryopreserved (−80° C.) as a receptor reference standard. Buffer B (50 μL) was added to a 96-well microassay plate (Corning Incorporated). The membrane reference standard suspended in buffer B at 250 μg/mL was added by 50 μL. A measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the total binding, 4 μM non-labeled SP diluted with a measurement buffer containing 2% dimethyl sulfoxide was added by 50 μL to examine the non-specific binding, and a test compound diluted with a measurement buffer (containing 2% dimethyl sulfoxide) was added by 50 μL to examine the binding inhibitory activity of the test compound. Furthermore, 400 μM 125I-Bolton-Hunter-SP (BH-SP) solution was added to each well by 50 μL. After reaction at room temperature for 30 min, the reaction was quenched using a cell harvester (PerkinElmer) by rapid filtration on a GF/C filter plate (PerkinElmer), and the cells were washed 10 times with 250 μL of a 50 mM Tris-hydrochloric acid buffer (pH 7.4) containing 0.02% bovine serum albumin. The GF/C filter plate was dried, MicroScinti-0 (PerkinElmer) was added by 20 μL, and the radioactivity was measured on a TopCount (PerkinElmer). The GF/C filter plate was immersed in 0.3% polyethyleneimine for one day before use.
ChEMBL 545 5 0 4 4.7 COc1ccc(C(=O)N(C)[C@@H]2CCN(C(=O)C3CCN(C(C)=O)CC3)CC2c2ccc(Cl)c(Cl)c2)cc1 nan
73265455 126517 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651894 126517 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 660 5 1 4 5.4 CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCN(C(=O)C(C)(C)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
3570748 57536 None 21 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 414 7 1 3 4.1 COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL166161 57536 None 21 Human Binding pIC50 = 8.6 8.6 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 414 7 1 3 4.1 COC1(C[S+]([O-])c2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL2390989 212870 None 17 Human Binding pIC50 = 8.6 8.6 - 1
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2013.03.016
44276792 99185 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL281019 99185 None 0 Human Binding pIC50 = 8.6 8.6 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 8 1 4 6.5 O=C1CCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44392445 66376 None 0 Human Binding pIC50 = 8.6 8.6 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185133 66376 None 0 Human Binding pIC50 = 8.6 8.6 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 495 8 0 3 5.2 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CCC1CC1 10.1016/j.bmcl.2005.05.134
2098 3694 None 31 Rat Binding pIC50 = 6.7 6.7 - 6
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
36511 3694 None 31 Rat Binding pIC50 = 6.7 6.7 - 6
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
3805 3694 None 31 Rat Binding pIC50 = 6.7 6.7 - 6
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
3835 3694 None 31 Rat Binding pIC50 = 6.7 6.7 - 6
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
CHEMBL235363 3694 None 31 Rat Binding pIC50 = 6.7 6.7 - 6
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None None 10.1021/jm00037a009
44335410 5002 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105009 5002 None 0 Human Binding pIC50 = 6.7 6.7 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 574 7 1 2 7.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1CCCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
44276738 97243 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26831 97243 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 560 6 0 2 7.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CCc4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
9874168 208162 None 3 Mouse Binding pIC50 = 7.7 7.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL82386 208162 None 3 Mouse Binding pIC50 = 7.7 7.7 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44312169 206886 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 492 5 3 2 5.4 O=C(Nc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL72140 206886 None 0 Human Binding pIC50 = 5.7 5.7 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 492 5 3 2 5.4 O=C(Nc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
76287260 125814 None 27 Human Binding pIC50 = 4.7 4.7 - 0
Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting method
ChEMBL 440 6 0 7 4.1 CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21 10.1021/acs.jmedchem.9b00322
CHEMBL3647536 125814 None 27 Human Binding pIC50 = 4.7 4.7 - 0
Displacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from recombinant human NK2 measured after 60 mins by scintillation counting method
ChEMBL 440 6 0 7 4.1 CCn1cnc2c(-c3ccc(F)c(-c4ccc(S(=O)(=O)CC)cc4OC)c3)cnnc21 10.1021/acs.jmedchem.9b00322
44312145 207174 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL74176 207174 None 0 Human Binding pIC50 = 6.7 6.7 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 7 3 2 5.1 O=C(NCCc1ccccc1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
9843958 203249 None 1 Human Binding pIC50 = 7.7 7.7 - 1
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL60064 203249 None 1 Human Binding pIC50 = 7.7 7.7 - 1
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/s0960-894x(01)00074-9
1212 1662 None 37 Human Binding pIC50 = 4.7 4.7 -389 65
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
204 1662 None 37 Human Binding pIC50 = 4.7 4.7 -389 65
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372 1662 None 37 Human Binding pIC50 = 4.7 4.7 -389 65
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
3372.0 1662 None 37 Human Binding pIC50 = 4.7 4.7 -389 65
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
CHEMBL726 1662 None 37 Human Binding pIC50 = 4.7 4.7 -389 65
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
DB00623 1662 None 37 Human Binding pIC50 = 4.7 4.7 -389 65
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 437 6 1 5 4.3 OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F nan
44319250 107063 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315322 107063 None 0 Mouse Binding pIC50 = 6.6 6.6 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 589 10 1 6 4.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
10099939 4989 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL104954 4989 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
9830304 107403 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
CHEMBL317632 107403 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 7 2 4 5.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cn(C)c2ccccc12 10.1016/s0960-894x(01)00631-x
10099939 4989 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL104954 4989 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44312257 102965 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306065 102965 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
25129133 188995 None 0 Rat Binding pIC50 = 7.6 7.6 -10 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL507340 188995 None 0 Rat Binding pIC50 = 7.6 7.6 -10 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1208 27 10 11 4.9 CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
23653789 3587 None 25 Human Binding pIC50 = 5.6 5.6 1 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
9280 3587 None 25 Human Binding pIC50 = 5.6 5.6 1 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
CHEMBL447955 3587 None 25 Human Binding pIC50 = 5.6 5.6 1 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
DB12973 3587 None 25 Human Binding pIC50 = 5.6 5.6 1 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm400751p
10350528 106789 None 0 Rat Binding pIC50 = 6.6 6.6 - 3
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106789 None 0 Rat Binding pIC50 = 6.6 6.6 - 3
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
2098 3694 None 31 Human Binding pIC50 = 6.6 6.6 -457 6
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
36511 3694 None 31 Human Binding pIC50 = 6.6 6.6 -457 6
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3805 3694 None 31 Human Binding pIC50 = 6.6 6.6 -457 6
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3835 3694 None 31 Human Binding pIC50 = 6.6 6.6 -457 6
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL235363 3694 None 31 Human Binding pIC50 = 6.6 6.6 -457 6
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
44379971 58770 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 398 3 2 3 3.5 [O-][S+](C[C@]1(O)CCN2CCc3c([nH]c4ccc(F)cc34)[C@H]2C1)c1ccccc1 10.1016/s0960-894x(01)00074-9
CHEMBL168632 58770 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 398 3 2 3 3.5 [O-][S+](C[C@]1(O)CCN2CCc3c([nH]c4ccc(F)cc34)[C@H]2C1)c1ccccc1 10.1016/s0960-894x(01)00074-9
44312028 102907 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL305609 102907 None 0 Human Binding pIC50 = 6.6 6.6 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 558 9 1 5 5.1 CSN1CC2(CCN(C(=O)N[C@@H](COCc3ccccc3)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
44335376 4547 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
CHEMBL102376 4547 None 0 Human Binding pIC50 = 7.6 7.6 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 717 7 2 4 6.3 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1cc(Br)c(Br)s1 10.1016/s0960-894x(01)00631-x
155565189 175669 None 0 Human Binding pIC50 = 6.6 6.6 2 4
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
CHEMBL4579120 175669 None 0 Human Binding pIC50 = 6.6 6.6 2 4
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
392622 56328 None 57 Human Binding pIC50 = 5.6 5.6 2 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
CHEMBL163 56328 None 57 Human Binding pIC50 = 5.6 5.6 2 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 720 17 4 9 5.9 CC(C)c1nc(CN(C)C(=O)N[C@H](C(=O)N[C@@H](Cc2ccccc2)C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)C(C)C)cs1 nan
28417 40052 None 36 Human Binding pIC50 = 4.6 4.6 -1 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
28417.0 40052 None 36 Human Binding pIC50 = 4.6 4.6 -1 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
CHEMBL1479 40052 None 36 Human Binding pIC50 = 4.6 4.6 -1 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
DB01406 40052 None 36 Human Binding pIC50 = 4.6 4.6 -1 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 0 1 3 4.2 C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C nan
2600 3779 None 53 Human Binding pIC50 = 5.6 5.6 -6 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
2608 3779 None 53 Human Binding pIC50 = 5.6 5.6 -6 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
5405 3779 None 53 Human Binding pIC50 = 5.6 5.6 -6 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
CHEMBL17157 3779 None 53 Human Binding pIC50 = 5.6 5.6 -6 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
DB00342 3779 None 53 Human Binding pIC50 = 5.6 5.6 -6 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O nan
9984184 207107 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73618 207107 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 520 6 2 2 5.4 CN(Cc1ccccc1)C(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCC2(CCc3ccccc32)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL2112246 211692 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
2726 919 None 48 Human Binding pIC50 = 4.6 4.6 -125 72
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
2726.0 919 None 48 Human Binding pIC50 = 4.6 4.6 -125 72
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
621 919 None 48 Human Binding pIC50 = 4.6 4.6 -125 72
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
83 919 None 48 Human Binding pIC50 = 4.6 4.6 -125 72
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
CHEMBL71 919 None 48 Human Binding pIC50 = 4.6 4.6 -125 72
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
DB00477 919 None 48 Human Binding pIC50 = 4.6 4.6 -125 72
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 318 4 0 3 4.9 CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C nan
10055928 116689 None 0 Golden hamster Binding pIC50 = 6.6 6.6 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 762 25 9 10 -1.0 CCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL336849 116689 None 0 Golden hamster Binding pIC50 = 6.6 6.6 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 762 25 9 10 -1.0 CCN(C[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)[C@@H](CC(C)C)C(N)=O 10.1021/jm00099a024
44319249 208530 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
CHEMBL85499 208530 None 0 Mouse Binding pIC50 = 5.6 5.6 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 631 12 1 8 4.4 COc1ccc(C2(CCN3CCC(C(N)=O)(c4ccccc4)CC3)CCN(C(=O)c3cc(OC)c(OC)c(OC)c3)C2)cc1OC 10.1016/S0960-894X(97)10013-0
9869033 100478 None 5 Bovine Binding pIC50 = 5.6 5.6 - 0
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
CHEMBL290364 100478 None 5 Bovine Binding pIC50 = 5.6 5.6 - 0
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 463 6 1 3 5.9 Cc1cc(C)cc(C(=O)N2CC[C@H](NCc3ccnc4ccccc34)C[C@H]2Cc2ccccc2)c1 10.1016/0960-894X(96)00287-9
71450941 79550 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113739 79550 None 0 Human Binding pIC50 = 7.6 7.6 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 595 5 2 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(F)cc1 10.1016/s0960-894x(02)00382-7
16220269 189769 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Inhibition of neurokinin 2 receptorInhibition of neurokinin 2 receptor
ChEMBL 361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O 10.1073/pnas.0605125104
CHEMBL515170 189769 None 0 Human Binding pIC50 = 4.6 4.6 - 0
Inhibition of neurokinin 2 receptorInhibition of neurokinin 2 receptor
ChEMBL 361 3 1 2 4.4 CC[C@@H]1O[C@](/C=C/C2CC2)(C(F)(F)F)c2c(ccc(F)c2F)NC1=O 10.1073/pnas.0605125104
53232 188732 None 57 Human Binding pIC50 = 4.6 4.6 1 2
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
CHEMBL503 188732 None 57 Human Binding pIC50 = 4.6 4.6 1 2
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 6 1 5 4.2 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21 nan
CHEMBL2115376 211726 None 0 Rat Binding pIC50 = 7.5 7.5 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
CHEMBL2369767 212143 None 0 Golden hamster Binding pIC50 = 5.5 5.5 - 0
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None C/C=C/CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCC(=O)N1)C(N)=O 10.1016/0960-894X(94)85022-4
64143 201320 None 42 Human Binding pIC50 = 4.5 4.5 -1 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
CHEMBL584 201320 None 42 Human Binding pIC50 = 4.5 4.5 -1 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 567 9 4 6 4.7 Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C nan
2247 505 None 55 Human Binding pIC50 = 5.5 5.5 -44 41
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
249 505 None 55 Human Binding pIC50 = 5.5 5.5 -44 41
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
2603 505 None 55 Human Binding pIC50 = 5.5 5.5 -44 41
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
CHEMBL296419 505 None 55 Human Binding pIC50 = 5.5 5.5 -44 41
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
DB00637 505 None 55 Human Binding pIC50 = 5.5 5.5 -44 41
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 458 8 1 5 5.4 COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2 nan
9831641 79728 None 5 Guinea pig Binding pIC50 = 8.5 8.5 - 0
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2115415 79728 None 5 Guinea pig Binding pIC50 = 8.5 8.5 - 0
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
44319224 107132 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL315814 107132 None 0 Mouse Binding pIC50 = 8.5 8.5 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 722 10 0 7 6.0 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCN(C)CC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44392392 130241 None 0 Human Binding pIC50 = 8.5 8.5 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367815 130241 None 0 Human Binding pIC50 = 8.5 8.5 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 555 7 0 4 5.4 O=C1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CCC(F)(F)CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
127032997 138619 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells
ChEMBL 748 24 10 10 -2.1 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL3775108 138619 None 0 Human Binding pIC50 = 8.5 8.5 - 0
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells
ChEMBL 748 24 10 10 -2.1 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.03.006
CHEMBL2390989 212870 None 17 Human Binding pIC50 = 8.5 8.5 - 1
Displacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]NKA from human recombinant NK2 receptor expressed in CHO cells measured after 60 mins by scintillation counting method
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.bmc.2016.11.014
137633652 156687 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
CHEMBL4068783 156687 None 0 Human Binding pIC50 = 8.4 8.4 - 1
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
2090 2767 None 27 Golden hamster Binding pIC50 = 8.4 8.4 - 4
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
5311312 2767 None 27 Golden hamster Binding pIC50 = 8.4 8.4 - 4
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
CHEMBL437797 2767 None 27 Golden hamster Binding pIC50 = 8.4 8.4 - 4
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL None None None None 10.1021/jm950892r
44319308 106434 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL313931 106434 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 709 10 0 7 6.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCOCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
15485361 97283 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL26860 97283 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 9 0 3 7.5 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCC(=O)N(Cc3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
9915372 127127 None 1 Human Binding pIC50 = 8.4 8.4 -1 2
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL365613 127127 None 1 Human Binding pIC50 = 8.4 8.4 -1 2
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 8 1 5 2.2 NS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44305557 205271 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL62341 205271 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1021/jm058225d
44305557 205271 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL62341 205271 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 522 8 2 5 6.3 COc1cc(C(=O)Nc2cc(C(=O)NC3CCCCC3)ccc2-c2ccc(Cl)cc2)cc(OC)c1OC 10.1016/s0960-894x(02)00382-7
CHEMBL431641 216087 None 0 Human Binding pIC50 = 7.5 7.5 - 1
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
71458099 79622 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL2114398 79622 None 0 Human Binding pIC50 = 6.5 6.5 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
155558726 174912 None 0 Human Binding pIC50 = 5.5 5.5 -3 4
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
CHEMBL4562303 174912 None 0 Human Binding pIC50 = 5.5 5.5 -3 4
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
5353853 17993 None 30 Human Binding pIC50 = 5.5 5.5 -14 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
9556529 17993 None 30 Human Binding pIC50 = 5.5 5.5 -14 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1262 17993 None 30 Human Binding pIC50 = 5.5 5.5 -14 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
44301871 100802 None 3 Golden hamster Binding pIC50 = 5.5 5.5 - 1
Concentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladderConcentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladder
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL292766 100802 None 3 Golden hamster Binding pIC50 = 5.5 5.5 - 1
Concentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladderConcentration required for binding affinity to neurokinin (NK2) receptor in hamster urinary bladder
ChEMBL 441 9 3 3 4.4 O=C(N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCCc1ccccc1)OCc1ccccc1 10.1016/S0960-894X(97)00346-6
CHEMBL311405 213558 None 15 Golden hamster Binding pIC50 = 5.5 5.5 - 0
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O 10.1016/0960-894X(94)85022-4
44212284 60008 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL173420 60008 None 0 Human Binding pIC50 = 7.5 7.5 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1ccc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c(OC)c1 10.1016/0960-894X(96)00148-5
CHEMBL102128 210913 None 0 Human Binding pIC50 = 5.5 5.5 - 1
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
23294214 169263 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL440465 169263 None 0 Human Binding pIC50 = 6.5 6.5 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 7 1 4 6.9 O=C(c1ccccc1)N1CCCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL406442 215068 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
1016 3747 None 45 Human Binding pIC50 = 5.4 5.4 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3747 None 45 Human Binding pIC50 = 5.4 5.4 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3747 None 45 Human Binding pIC50 = 5.4 5.4 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3747 None 45 Human Binding pIC50 = 5.4 5.4 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3747 None 45 Human Binding pIC50 = 5.4 5.4 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3747 None 45 Human Binding pIC50 = 5.4 5.4 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL103939 210919 None 0 Human Binding pIC50 = 6.4 6.4 - 1
Inhibitory activity against human Tachykinin receptor 2Inhibitory activity against human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
CHEMBL2115375 211725 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
1836 2592 None 44 Human Binding pIC50 = 5.4 5.4 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
3340 2592 None 44 Human Binding pIC50 = 5.4 5.4 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
5281040 2592 None 44 Human Binding pIC50 = 5.4 5.4 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
5281040.0 2592 None 44 Human Binding pIC50 = 5.4 5.4 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
CHEMBL787 2592 None 44 Human Binding pIC50 = 5.4 5.4 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
DB00471 2592 None 44 Human Binding pIC50 = 5.4 5.4 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
9832198 106811 None 0 Rat Binding pIC50 = 6.4 6.4 - 3
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144351 106811 None 0 Rat Binding pIC50 = 6.4 6.4 - 3
Tested for binding affinity against rat NK-2 receptorTested for binding affinity against rat NK-2 receptor
ChEMBL 788 15 4 8 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCC(=O)O)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10393390 98330 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL27463 98330 None 0 Human Binding pIC50 = 6.4 6.4 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 576 8 0 3 7.6 CC(=O)C1(c2ccccc2)CCN(CCCC2(c3ccc(Cl)c(Cl)c3)CCCN(C(=O)c3ccccc3)C2)CC1 10.1016/s0960-894x(98)00215-7
CHEMBL216813 211800 None 0 Rat Binding pIC50 = 5.4 5.4 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1Cc2ccccc2C1)C(N)=O 10.1021/jm00037a009
132837 2237 None 40 Rat Binding pIC50 = 6.4 6.4 -18 5
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2237 None 40 Rat Binding pIC50 = 6.4 6.4 -18 5
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2237 None 40 Rat Binding pIC50 = 6.4 6.4 -18 5
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
2351 3286 None 44 Human Binding pIC50 = 5.4 5.4 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 3286 None 44 Human Binding pIC50 = 5.4 5.4 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 3286 None 44 Human Binding pIC50 = 5.4 5.4 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 3286 None 44 Human Binding pIC50 = 5.4 5.4 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 3286 None 44 Human Binding pIC50 = 5.4 5.4 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
44386230 61383 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
CHEMBL176811 61383 None 0 Human Binding pIC50 = 8.4 8.4 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 735 8 1 4 7.2 COc1c(Br)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1Br 10.1016/0960-894X(96)00148-5
44319084 13702 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1194867 13702 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL553451 13702 None 0 Mouse Binding pIC50 = 8.4 8.4 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 723 10 0 8 5.4 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(=O)N4CCN(C)CC4)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
133 2496 None 39 Human Binding pIC50 = 5.4 5.4 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 2496 None 39 Human Binding pIC50 = 5.4 5.4 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 2496 None 39 Human Binding pIC50 = 5.4 5.4 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 2496 None 39 Human Binding pIC50 = 5.4 5.4 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 2496 None 39 Human Binding pIC50 = 5.4 5.4 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL405209 215009 None 0 Rat Binding pIC50 = 7.4 7.4 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
49863731 15336 None 0 Rat Binding pIC50 = 7.4 7.4 -5 3
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 15336 None 0 Rat Binding pIC50 = 7.4 7.4 -5 3
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
1024 1289 None 44 Human Binding pIC50 = 5.4 5.4 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
162639143 1289 None 44 Human Binding pIC50 = 5.4 5.4 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
5284373 1289 None 44 Human Binding pIC50 = 5.4 5.4 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
760 1289 None 44 Human Binding pIC50 = 5.4 5.4 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL160 1289 None 44 Human Binding pIC50 = 5.4 5.4 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
DB00091 1289 None 44 Human Binding pIC50 = 5.4 5.4 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
3598 187927 None 45 Human Binding pIC50 = 5.4 5.4 -1 7
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
CHEMBL496 187927 None 45 Human Binding pIC50 = 5.4 5.4 -1 7
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
73265454 126516 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3651893 126516 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 646 5 1 4 6.3 COC(=O)N[C@H]1CC[C@H](C(=O)N2C[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44384677 131526 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
CHEMBL369174 131526 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 667 11 1 6 6.5 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC(C)C 10.1016/0960-894X(96)00148-5
73265449 124479 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
CHEMBL3639507 124479 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 630 4 0 3 6.0 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(F)cc3)C2)CC1 nan
44312285 103012 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL306400 103012 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 703 7 2 4 7.6 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
122179477 121538 None 9 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of NK2 receptor (unknown origin)Inhibition of NK2 receptor (unknown origin)
ChEMBL 525 5 3 9 3.2 CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 10.1021/ml500514w
CHEMBL3582336 121538 None 9 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of NK2 receptor (unknown origin)Inhibition of NK2 receptor (unknown origin)
ChEMBL 525 5 3 9 3.2 CCn1cc([C@@]2(c3nn(C)c(=O)o3)N[C@@H](c3nc(-c4ccc(F)cn4)c[nH]3)Cc3c2[nH]c2ccccc32)cn1 10.1021/ml500514w
71449072 78609 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
CHEMBL2112212 78609 None 0 Human Binding pIC50 = 7.4 7.4 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 645 5 2 3 7.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00382-7
11059058 10093 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
CHEMBL115444 10093 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 429 3 1 7 4.1 O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1 10.1021/jm010878g
10350454 106787 None 0 Human Binding pIC50 = 7.4 7.4 - 3
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144209 106787 None 0 Human Binding pIC50 = 7.4 7.4 - 3
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 815 18 4 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)CCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44290659 101588 None 0 Guinea pig Binding pIC50 = 7.4 7.4 - 0
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL298247 101588 None 0 Guinea pig Binding pIC50 = 7.4 7.4 - 0
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL411230 215334 None 0 Rat Binding pIC50 = 6.4 6.4 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44288896 169090 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
CHEMBL43912 169090 None 0 Bovine Binding pIC50 = 5.4 5.4 - 0
Compound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladderCompound was tested for inhibition of [125I]NKA radioligand binding to NK2 receptor from bovine bladder
ChEMBL 517 5 1 3 6.2 O=C(N[C@H]1CCN(C(=O)c2cc(Cl)cc(Cl)c2)[C@H](Cc2ccccc2)C1)c1ccnc2ccccc12 10.1016/0960-894X(96)00287-9
44312256 207038 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL73097 207038 None 0 Human Binding pIC50 = 5.4 5.4 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 554 7 2 5 5.7 CSN1CC2(CCN(C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)OCc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
1752 45775 None 35 Human Binding pIC50 = 5.3 5.3 -1 5
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
CHEMBL153062 45775 None 35 Human Binding pIC50 = 5.3 5.3 -1 5
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
1548953 210138 None 21 Human Binding pIC50 = 5.3 5.3 -7 17
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL954 210138 None 21 Human Binding pIC50 = 5.3 5.3 -7 17
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL1201469 14513 None 0 Human Binding pIC50 = 5.3 5.3 1 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL2112245 211691 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@@H](O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC1=O 10.1021/jm000316h
10350528 106789 None 0 Human Binding pIC50 = 7.3 7.3 - 3
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144210 106789 None 0 Human Binding pIC50 = 7.3 7.3 - 3
Tested for binding affinity against human NK-2 receptorTested for binding affinity against human NK-2 receptor
ChEMBL 831 18 4 9 4.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C(=O)OCCCCCCN)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
11951302 104900 None 0 Human Binding pIC50 = 4.3 4.3 - 1
Antagonist activity at human NK2 receptorAntagonist activity at human NK2 receptor
ChEMBL 404 7 2 5 3.5 COCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1 10.1021/jm4010708
CHEMBL3109772 104900 None 0 Human Binding pIC50 = 4.3 4.3 - 1
Antagonist activity at human NK2 receptorAntagonist activity at human NK2 receptor
ChEMBL 404 7 2 5 3.5 COCCOc1ncc(C(=O)N[C@@H]2CCCC[C@H]2O)cc1-c1ccc(Cl)cc1 10.1021/jm4010708
2406 100458 None 56 Human Binding pIC50 = 5.3 5.3 -16 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL290106 100458 None 56 Human Binding pIC50 = 5.3 5.3 -16 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
4189 209380 None 58 Human Binding pIC50 = 5.3 5.3 -18 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 209380 None 58 Human Binding pIC50 = 5.3 5.3 -18 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 209380 None 58 Human Binding pIC50 = 5.3 5.3 -18 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
10439730 106813 None 0 Rat Binding pIC50 = 6.3 6.3 - 3
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106813 None 0 Rat Binding pIC50 = 6.3 6.3 - 3
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
44402934 71096 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
CHEMBL195222 71096 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity towards tachykinin receptor 2Binding affinity towards tachykinin receptor 2
ChEMBL 589 9 1 3 6.2 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NCCN1CCCCC1)Cc1ccc(Cl)cc1 10.1021/jm058225d
10379 3059 None 37 Human Binding pIC50 = 5.3 5.3 - 1
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
9884366 3059 None 37 Human Binding pIC50 = 5.3 5.3 - 1
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
CHEMBL482950 3059 None 37 Human Binding pIC50 = 5.3 5.3 - 1
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
DB12572 3059 None 37 Human Binding pIC50 = 5.3 5.3 - 1
Binding affinity to human neurokinin 2 receptorBinding affinity to human neurokinin 2 receptor
ChEMBL 340 5 1 7 3.3 CC[C@H](Nc1nc(C)nc2n1nc(c2c1ccc(nc1C)OC)C)C 10.1021/jm900025h
CHEMBL264341 213073 None 0 Rat Binding pIC50 = 5.3 5.3 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C/c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
5318 15583 None 40 Human Binding pIC50 = 5.3 5.3 -1 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1200348 15583 None 40 Human Binding pIC50 = 5.3 5.3 -1 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1221 15583 None 40 Human Binding pIC50 = 5.3 5.3 -1 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
9939040 5012 None 7 Human Binding pIC50 = 8.3 8.3 -2 4
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL105060 5012 None 7 Human Binding pIC50 = 8.3 8.3 -2 4
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
44335319 107566 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
CHEMBL318606 107566 None 0 Human Binding pIC50 = 8.3 8.3 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 626 8 2 4 5.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00631-x
25109291 191495 None 6 Human Binding pIC50 = 8.2 8.2 -72 12
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
CHEMBL519240 191495 None 6 Human Binding pIC50 = 8.2 8.2 -72 12
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
10101612 117361 None 0 Golden hamster Binding pIC50 = 7.3 7.3 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 752 25 10 11 -2.0 CSCC[C@H](NC[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL339615 117361 None 0 Golden hamster Binding pIC50 = 7.3 7.3 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 752 25 10 11 -2.0 CSCC[C@H](NC[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44276673 97410 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
CHEMBL26951 97410 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 604 7 1 4 6.6 O=C(c1ccccc1)N1CCCC(CCCN2CCC3(CC2)CN(c2ccccc2)NC3=O)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(98)00215-7
11989776 2704 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
2130 2704 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
CHEMBL221445 2704 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Inhibition of human NK2 receptorInhibition of human NK2 receptor
ChEMBL 569 5 1 6 5.9 COC(=O)N(c1ccccc1)NC(=O)c1c(CN2CCN(CC2)C(C)(C)C)c(nc2c1cccc2F)c1ccccc1 10.1016/j.bmcl.2006.08.085
44305271 102299 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
CHEMBL303119 102299 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 528 4 0 2 7.0 CN(C)C(=O)c1ccc(-c2ccc(Cl)cc2)c(N(C)C(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c1 10.1016/s0960-894x(02)00382-7
44291515 101192 None 0 Golden hamster Binding pIC50 = 5.3 5.3 - 0
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
CHEMBL295301 101192 None 0 Golden hamster Binding pIC50 = 5.3 5.3 - 0
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 580 17 4 5 4.6 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCC(N)=O 10.1016/S0960-894X(00)80360-1
44305544 205532 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL63785 205532 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity was determined by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 582 5 1 2 8.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCC2)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
5362440 10023 None 41 Human Binding pIC50 = 5.3 5.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
CHEMBL115 10023 None 41 Human Binding pIC50 = 5.3 5.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
CHEMBL5483011 10023 None 41 Human Binding pIC50 = 5.3 5.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
10907460 9830 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL113956 9830 None 0 Human Binding pIC50 = 5.3 5.3 - 0
Binding affinity against tachykinin receptor 2Binding affinity against tachykinin receptor 2
ChEMBL 521 11 1 3 5.8 CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1 10.1021/jm010878g
CHEMBL2372444 212704 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
44281769 109716 None 4 Golden hamster Binding pIC50 = 5.3 5.3 - 0
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00254-Q
CHEMBL32248 109716 None 4 Golden hamster Binding pIC50 = 5.3 5.3 - 0
Binding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligandBinding affinity towards Tachykinin receptor 2 using [125I]iodohistidyl-NKA (0.1 nM)) as radioligand
ChEMBL 484 10 4 4 3.2 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)OCc1ccccc1 10.1016/0960-894X(95)00254-Q
44345938 12007 None 0 Golden hamster Binding pIC50 = 5.3 5.3 - 0
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
CHEMBL118328 12007 None 0 Golden hamster Binding pIC50 = 5.3 5.3 - 0
Tested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladderTested for binding affinity of compound against [125I]NKA binding to neurokinin-2 (NK-2) receptor in hamster urinary bladder
ChEMBL 350 7 4 3 1.3 NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 10.1016/S0960-894X(96)00570-7
44212281 130684 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL368159 130684 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 609 9 1 5 5.7 COc1cccc(OC)c1C(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL2114442 211713 None 0 Rat Binding pIC50 = 6.3 6.3 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
44190762 176985 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of radioligand from tachykinin NK2 receptorDisplacement of radioligand from tachykinin NK2 receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
CHEMBL461571 176985 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Displacement of radioligand from tachykinin NK2 receptorDisplacement of radioligand from tachykinin NK2 receptor
ChEMBL 531 8 1 5 6.6 Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1 10.1016/j.bmcl.2008.07.103
44386105 131998 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
CHEMBL369498 131998 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 621 10 1 4 6.4 CC(C)Oc1cccc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/0960-894X(96)00148-5
44335360 4867 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL104348 4867 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 608 8 2 4 5.5 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N(CCC(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
10077113 121607 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
CHEMBL35857 121607 None 0 Human Binding pIC50 = 7.3 7.3 - 0
In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2In vitro inhibition of [125I]NKA binding to transfected Chinese hamster ovary cells (CHO cells) expressing recombinant human Tachykinin receptor 2
ChEMBL 589 7 2 3 5.4 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(/C=C/C(=O)NC1CCCCNC1=O)Cc1ccc(Cl)cc1 10.1016/s0960-894x(00)00260-2
44385575 59816 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL172676 59816 None 0 Human Binding pIC50 = 7.3 7.3 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 653 11 1 6 5.6 COc1cc(CC(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
44411637 139367 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
CHEMBL379097 139367 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Inhibition of human NK2 receptor expressed in CHO cellsInhibition of human NK2 receptor expressed in CHO cells
ChEMBL 441 4 1 3 4.5 O=C(CC1CCN(C(=O)c2cccc(C#Cc3ccccn3)c2)CC1)Nc1ccccc1F 10.1016/j.bmcl.2006.02.027
10076881 163011 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
CHEMBL417407 163011 None 0 Human Binding pIC50 = 6.3 6.3 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 577 5 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)NC2CCCCNC2=O)ccc1-c1ccccc1 10.1016/s0960-894x(02)00382-7
10055770 117540 None 0 Golden hamster Binding pIC50 = 5.3 5.3 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL339941 117540 None 0 Golden hamster Binding pIC50 = 5.3 5.3 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 734 24 10 10 -1.7 CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
CHEMBL2114443 211714 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)[C@@H]1CCc2ccccc21)C(N)=O 10.1021/jm00037a009
44319355 105578 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL312173 105578 None 0 Mouse Binding pIC50 = 7.2 7.2 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 605 10 1 6 5.1 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)cc3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
71450949 79580 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
CHEMBL2114103 79580 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 567 7 2 4 5.6 CSN1CC2(CCN(C(=O)N[C@H](Cc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)CC2)c2ccccc21 10.1016/s0960-894x(98)00395-3
11790 99541 None 62 Human Binding pIC50 = 5.2 5.2 -2 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
CHEMBL283196 99541 None 62 Human Binding pIC50 = 5.2 5.2 -2 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
73265456 126518 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651895 126518 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 590 4 1 3 5.7 CN(C(=O)N(C)[C@@H]1CN(C(=O)NC2CCOCC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
71461705 79649 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL2114963 79649 None 0 Guinea pig Binding pIC50 = 7.2 7.2 - 0
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 672 8 0 7 6.0 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[S@@+]4[O-])(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
9916195 120563 None 3 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 576 7 1 4 5.0 CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL354422 120563 None 3 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligandBinding affinity for heterologously expressed human Tachykinin receptor 2 using [3H]-SR- 48968 as radioligand
ChEMBL 576 7 1 4 5.0 CN(C)C(=O)NC1(c2ccccc2)CCN(CC[C@@]2(c3ccc(F)c(F)c3)CN(C(=O)c3ccccc3)CCO2)CC1 10.1016/s0960-894x(01)00074-9
CHEMBL126294 211126 None 14 Golden hamster Binding pIC50 = 8.2 8.2 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1021/jm00099a024
44310284 206834 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 465 7 0 4 3.7 O=C(CC1CC1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL71784 206834 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 465 7 0 4 3.7 O=C(CC1CC1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310102 206851 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 418 7 0 2 5.7 CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71918 206851 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 418 7 0 2 5.7 CN(CC(CCN1CCCCC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
10950925 129722 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL367348 129722 None 0 Human Binding pIC50 = 8.2 8.2 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 478 7 1 4 3.8 NC1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44309946 206375 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 434 7 1 3 4.7 CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL69065 206375 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 434 7 1 3 4.7 CN(CC(CCN1CCC(O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
23294208 97201 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
CHEMBL26790 97201 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Compound was evaluated for affinity towards human Neurokinin NK2 receptorCompound was evaluated for affinity towards human Neurokinin NK2 receptor
ChEMBL 590 8 1 4 6.8 O=C1CCC(CCCN2CCC(n3c(=O)[nH]c4ccccc43)CC2)(c2ccc(Cl)c(Cl)c2)CN1Cc1ccccc1 10.1016/s0960-894x(98)00215-7
44310237 103838 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 517 7 0 5 4.2 COc1ccccc1C(=O)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL308901 103838 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 517 7 0 5 4.2 COc1ccccc1C(=O)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44309945 103122 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 500 8 2 4 4.9 CN(CC(CCN1CCC(O)(c2ncc[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL307338 103122 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 500 8 2 4 4.9 CN(CC(CCN1CCC(O)(c2ncc[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310282 206541 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 523 7 0 5 3.7 O=S(=O)(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL70157 206541 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 523 7 0 5 3.7 O=S(=O)(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
10394084 119908 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 618 9 1 5 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc(C2(C(F)(F)F)N=N2)c1 10.1016/0960-894X(96)00075-3
CHEMBL348599 119908 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligandBinding affinity was determined against human NK2 receptor in CHO cells using [125I]neurokinin A as radioligand
ChEMBL 618 9 1 5 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc(C2(C(F)(F)F)N=N2)c1 10.1016/0960-894X(96)00075-3
44310456 102829 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 485 8 0 5 5.2 CN(CC(CCN1CCC(n2cncn2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL305191 102829 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 485 8 0 5 5.2 CN(CC(CCN1CCC(n2cncn2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310433 206818 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 456 8 0 4 5.0 CN(CC(CCN1CC(n2ccnc2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71704 206818 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 456 8 0 4 5.0 CN(CC(CCN1CC(n2ccnc2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
11498370 101230 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
CHEMBL295615 101230 None 0 Guinea pig Binding pIC50 = 8.2 8.2 - 0
The compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membraneThe compound was evaluated in vitro for its ability to displace [3H]SP from Tachykinin receptor 2 of male guinea pig lung membrane
ChEMBL 654 8 1 7 5.7 COc1cc(C(=O)N2CCO[C@](CCN3CCC4(CC3)c3ccccc3C[C@@H]4O)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(00)00324-3
44386231 61400 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
CHEMBL176951 61400 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 607 8 1 4 6.3 COc1c(C)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1C 10.1016/0960-894X(96)00148-5
44335372 4776 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL103979 4776 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 605 7 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc2ccccc2c1 10.1016/s0960-894x(01)00631-x
CHEMBL2372517 212725 None 0 Rat Binding pIC50 = 5.2 5.2 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
3198 207971 None 50 Human Binding pIC50 = 5.2 5.2 -21 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 207971 None 50 Human Binding pIC50 = 5.2 5.2 -21 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 207971 None 50 Human Binding pIC50 = 5.2 5.2 -21 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
138106885 167007 None 49 Human Binding pIC50 = 5.2 5.2 -1 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
36314 167007 None 49 Human Binding pIC50 = 5.2 5.2 -1 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
CHEMBL428647 167007 None 49 Human Binding pIC50 = 5.2 5.2 -1 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
44291788 101467 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 0
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
CHEMBL297327 101467 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 0
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@](C)(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCCCCCCO 10.1016/S0960-894X(00)80360-1
44291015 101281 None 2 Golden hamster Binding pIC50 = 5.2 5.2 - 0
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@](C)(Cc1ccccc1)C(=O)NCCCCCCCCO 10.1021/jm950892r
CHEMBL296014 101281 None 2 Golden hamster Binding pIC50 = 5.2 5.2 - 0
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 553 16 4 5 4.7 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@](C)(Cc1ccccc1)C(=O)NCCCCCCCCO 10.1021/jm950892r
441243 9838 None 41 Human Binding pIC50 = 5.2 5.2 -19 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL114 9838 None 41 Human Binding pIC50 = 5.2 5.2 -19 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL307433 213439 None 0 Golden hamster Binding pIC50 = 6.2 6.2 - 0
Concentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladderConcentration producing half-maximal inhibition of specific binding of. [125I]neurokinin A to NK-2 receptors in the hamster urinary bladder
ChEMBL None None None CCCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(N)=O 10.1016/0960-894X(94)85022-4
10055415 106812 None 0 Human Binding pIC50 = 7.2 7.2 - 3
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106812 None 0 Human Binding pIC50 = 7.2 7.2 - 3
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10055415 106812 None 0 Rat Binding pIC50 = 7.2 7.2 - 3
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144352 106812 None 0 Rat Binding pIC50 = 7.2 7.2 - 3
Tested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against rat NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 688 12 4 5 3.2 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
2125 3030 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 1
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
5311350 3030 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 1
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
CHEMBL444832 3030 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 1
Binding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligandBinding affinity for NK2 receptor binding sites in membranes prepared from hamster urinary bladder by using [125I]NKA as radioligand
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1016/S0960-894X(00)80360-1
2125 3030 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 1
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
5311350 3030 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 1
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
CHEMBL444832 3030 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 1
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 581 16 5 5 4.0 NC(=O)NCCCCCCCNC(=O)[C@@](Cc1ccccc1)(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C 10.1021/jm950892r
44335318 5107 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
CHEMBL105600 5107 None 0 Human Binding pIC50 = 7.2 7.2 - 0
In vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligandIn vitro binding affinity for Tachykinin receptor 2 of human-CHO cells using 125 I-NKA radioligand
ChEMBL 603 8 2 3 5.9 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)NC1(C(N)=O)CCCCC1)Cc1ccc(Cl)cc1 10.1016/s0960-894x(01)00631-x
49863733 15338 None 0 Rat Binding pIC50 = 6.2 6.2 -2 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15338 None 0 Rat Binding pIC50 = 6.2 6.2 -2 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL410808 215303 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(c1ccccc1)c1ccccc1)C(N)=O 10.1021/jm00037a009
5354 155746 None 16 Human Binding pIC50 = 5.2 5.2 -25 14
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 nan
CHEMBL404849 155746 None 16 Human Binding pIC50 = 5.2 5.2 -25 14
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 nan
CHEMBL405422 215021 None 0 Rat Binding pIC50 = 7.2 7.2 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)SC)C(N)=O 10.1021/jm00037a009
3040489 44575 None 1 Golden hamster Binding pIC50 = 5.2 5.2 - 0
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uM
ChEMBL 318 4 1 2 3.8 O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL151990 44575 None 1 Golden hamster Binding pIC50 = 5.2 5.2 - 0
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 4.6-9.0 uM
ChEMBL 318 4 1 2 3.8 O=C1CCN(Cc2ccccc2)CC1Cc1c[nH]c2ccccc12 10.1016/0960-894X(94)80030-8
CHEMBL264353 213077 None 0 Rat Binding pIC50 = 6.2 6.2 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C1c2ccccc2-c2ccccc21)C(N)=O 10.1021/jm00037a009
44366600 42946 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 0
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uM
ChEMBL 360 5 1 2 3.8 O=C1CCN(C(=O)CCc2c[nH]c3ccccc23)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
CHEMBL150346 42946 None 0 Golden hamster Binding pIC50 = 5.2 5.2 - 0
Binding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uMBinding affinity towards Tachykinin receptor 2 in hamster urinary bladder using [125I]neurokinin A as radioligand; Value ranges from 2.6-11 uM
ChEMBL 360 5 1 2 3.8 O=C1CCN(C(=O)CCc2c[nH]c3ccccc23)CC1Cc1ccccc1 10.1016/0960-894X(94)80030-8
135449286 193298 None 1 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
CHEMBL52330 193298 None 1 Human Binding pIC50 = 8.2 8.2 - 0
Displacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]-labeled SP from the human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 6 2 5 4.3 O=c1[nH]nc(CN2CCO[C@H](OCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@@H]2c2ccccc2)[nH]1 10.1021/jm950654w
44212285 123885 None 1 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
CHEMBL362394 123885 None 1 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 549 7 1 3 5.7 NC(=O)C1(c2ccccc2)CCN(CCC2(c3ccc(Cl)c(Cl)c3)CCN(C(=O)c3ccccc3)C2)CC1 10.1016/0960-894X(96)00148-5
73265450 126510 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
CHEMBL3651887 126510 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 680 4 0 3 7.2 CC(=O)N1CCC(C(=O)N2CC[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)[C@H](c3ccc(Cl)c(Cl)c3)C2)CC1 nan
87318292 126520 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
CHEMBL3651897 126520 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 616 4 0 3 5.6 CC(=O)N1CCC(C(=O)N2C[C@H](c3ccc(F)cc3)[C@@H](N(C)C(=O)N(C)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)C2)CC1 nan
44310105 206760 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71394 206760 None 0 Human Binding pIC50 = 8.2 8.2 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310432 206811 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 473 6 0 4 3.8 O=C(c1ccccc1)N1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL71644 206811 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 473 6 0 4 3.8 O=C(c1ccccc1)N1CC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310150 102763 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 1 3 7.0 CN(CC(CCN1CCC(c2nc3ccccc3[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL304807 102763 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 1 3 7.0 CN(CC(CCN1CCC(c2nc3ccccc3[nH]2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310262 206731 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 536 8 1 5 6.2 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71226 206731 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 536 8 1 5 6.2 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44310238 206502 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 487 6 0 4 4.2 O=C(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
CHEMBL69889 206502 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 487 6 0 4 4.2 O=C(c1ccccc1)N1CCC(CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(03)00343-3
44310165 206352 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 484 8 0 4 5.8 CN(CC(CCN1CCC(n2ccnc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL68917 206352 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 484 8 0 4 5.8 CN(CC(CCN1CCC(n2ccnc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
10005190 206812 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 475 8 0 4 4.3 CN(CC(CCN1CC(N2CCOCC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71647 206812 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 475 8 0 4 4.3 CN(CC(CCN1CC(N2CCOCC2)C1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
44319323 13752 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL1195230 13752 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL554092 13752 None 0 Mouse Binding pIC50 = 8.1 8.1 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 640 10 1 7 5.1 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4cccnc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
9807403 66705 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL185452 66705 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 542 8 0 5 2.9 CS(=O)(=O)N1CCN(C2CN(CC[C@]3(c4ccc(Cl)c(Cl)c4)CCC(=O)N(CC4CC4)C3)C2)CC1 10.1016/j.bmcl.2005.05.134
44392347 122194 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
CHEMBL359655 122194 None 0 Human Binding pIC50 = 8.1 8.1 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 543 7 0 4 5.1 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CCC(F)(F)CC1 10.1016/j.bmcl.2005.05.134
71449143 79551 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2113740 79551 None 0 Human Binding pIC50 = 7.2 7.2 - 0
Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2Binding affinity by measuring the inhibition of 125 I-NKA binding to transfected CHO cells expressing human recombinant Tachykinin receptor 2
ChEMBL 611 5 2 3 6.7 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1cc(C(=O)N[C@@H]2CCCCNC2=O)ccc1-c1ccc(Cl)cc1 10.1016/s0960-894x(02)00382-7
CHEMBL2371928 212613 None 0 Human Binding pIC50 = 6.2 6.2 - 0
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC(=O)NC(=O)N1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@H](Cc1ccccc1)C(N)=O 10.1016/j.bmcl.2006.07.036
25028925 91399 None 3 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2402572 91399 None 3 Human Binding pIC50 = 5.1 5.1 - 0
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 570 5 1 5 5.5 Cc1ccccc1[C@@H]1[C@@H](O[C@H](CO)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC[C@@H]2CN(C3=NC(=O)CO3)C[C@H]21 10.1021/jm400751p
CHEMBL2369630 212104 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
44212283 59879 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
CHEMBL172915 59879 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 593 9 1 4 5.6 COc1ccccc1CC(=O)N1CCC(CCN2CCC(C(N)=O)(c3ccccc3)CC2)(c2ccc(Cl)c(Cl)c2)C1 10.1016/0960-894X(96)00148-5
44319356 104426 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL310173 104426 None 0 Mouse Binding pIC50 = 7.1 7.1 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 607 10 1 6 4.7 COc1cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(F)c(F)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
73265457 126519 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
CHEMBL3651896 126519 None 0 Human Binding pIC50 = 7.1 7.1 - 0
Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.Binding Assay: Radioligand receptor binding inhibitory assay using human NK receptor.
ChEMBL 653 4 0 4 4.5 CN(C(=O)N(C)[C@@H]1CN(C(=O)N2CCN(S(C)(=O)=O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 nan
10439730 106813 None 0 Human Binding pIC50 = 7.1 7.1 - 3
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
CHEMBL3144353 106813 None 0 Human Binding pIC50 = 7.1 7.1 - 3
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 702 12 3 6 3.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)C[C@@H]1NC(=O)[C@@H]2C3CCC(CC3)N2C1=O 10.1021/jm00063a015
10972666 123012 None 0 Human Binding pIC50 = 7.1 7.1 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
CHEMBL360721 123012 None 0 Human Binding pIC50 = 7.1 7.1 - 1
Inhibition of human Neurokinin 2 receptorInhibition of human Neurokinin 2 receptor
ChEMBL 465 7 0 4 3.7 O=C1CC[C@](CCN2CC(N3CCOCC3)C2)(c2ccc(Cl)c(Cl)c2)CN1CC1CC1 10.1016/j.bmcl.2005.05.134
9915428 173737 None 4 Golden hamster Binding pIC50 = 6.1 6.1 - 0
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
CHEMBL45340 173737 None 4 Golden hamster Binding pIC50 = 6.1 6.1 - 0
Compound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligandCompound was tested for binding affinity towards Tachykinin receptor 2 binding sites in membranes prepared from hamster urinary bladder using [125I]neurokinin A as radioligand
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1016/0960-894X(95)00313-I
9915428 173737 None 4 Golden hamster Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
CHEMBL45340 173737 None 4 Golden hamster Binding pIC50 = 6.1 6.1 - 0
Inhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKAInhibitory activity against Tachykinin receptor 2 in membranes prepared from hamster urinary bladder labeled with [125 I] NKA
ChEMBL 546 15 4 4 5.1 CC(C)[C@H](OC(=O)N[C@](C)(Cc1cccc(F)c1F)C(=O)NCCCCCCCNC(N)=O)c1ccccc1 10.1021/jm950892r
44310151 102833 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 0 4 6.9 CN(CC(CCN1CCC(n2cnc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL305236 102833 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 534 8 0 4 6.9 CN(CC(CCN1CCC(n2cnc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
153996 112731 None 0 Human Binding pIC50 = 8.1 8.1 -3 3
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL330366 112731 None 0 Human Binding pIC50 = 8.1 8.1 -3 3
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
CHEMBL539021 112731 None 0 Human Binding pIC50 = 8.1 8.1 -3 3
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/0960-894X(96)00148-5
153996 112731 None 0 Mouse Binding pIC50 = 8.1 8.1 - 3
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL330366 112731 None 0 Mouse Binding pIC50 = 8.1 8.1 - 3
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL539021 112731 None 0 Mouse Binding pIC50 = 8.1 8.1 - 3
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44310139 207168 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 564 8 1 5 7.0 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL74127 207168 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 564 8 1 5 7.0 CN(CC(CCN1CCCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
9831309 135333 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
CHEMBL372587 135333 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Inhibitory concentration against tachykinin receptor 2Inhibitory concentration against tachykinin receptor 2
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1021/jm058225d
21831101 206279 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL68440 206279 None 0 Human Binding pIC50 = 8.1 8.1 - 0
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 550 8 1 5 6.6 CN(CC(CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
18964186 206762 None 0 Human Binding pIC50 = 8.1 8.1 - 3
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
CHEMBL71397 206762 None 0 Human Binding pIC50 = 8.1 8.1 - 3
Binding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligandBinding affinity for human tachykinin receptor 2 expressed in CHO cells using [125I]- NKA radioligand
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(03)00343-3
9850582 199698 None 20 Human Binding pIC50 = 8.1 8.1 -1 6
Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cellsBinding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(03)00343-3
CHEMBL56835 199698 None 20 Human Binding pIC50 = 8.1 8.1 -1 6
Binding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cellsBinding affinity towards human Tachykinin receptor 2 using [125I]- NKA radioligand expressed in CHO cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(03)00343-3
21121353 101528 None 0 Rat Binding pIC50 = 6.1 6.1 - 3
Tested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101528 None 0 Rat Binding pIC50 = 6.1 6.1 - 3
Tested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for the binding affinity against rat neurokinin-2 (NK-2) receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL2369631 212105 None 0 Human Binding pIC50 = 6.1 6.1 - 0
Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.Tested for binding affinity against Tachykinin receptor 2 expressed in CHO cells, using [125]SP as radioligand.
ChEMBL None None None C[C@H](NC(=O)CN)C(=O)N[C@H]1CSSC[C@H](C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC1=O 10.1021/jm000316h
2683 102943 None 17 Human Binding pIC50 = 5.1 5.1 -398 16
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL305906 102943 None 17 Human Binding pIC50 = 5.1 5.1 -398 16
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL334255 102943 None 17 Human Binding pIC50 = 5.1 5.1 -398 16
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
579 3144 None 18 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
6918468 3144 None 18 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
CHEMBL41547 3144 None 18 Human Binding pIC50 = 7.1 7.1 - 0
Binding affinity to NK2 receptorBinding affinity to NK2 receptor
ChEMBL None None None None 10.1016/j.bmcl.2006.07.036
10259606 118173 None 0 Golden hamster Binding pIC50 = 8.1 8.1 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 768 24 10 10 -1.5 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL340743 118173 None 0 Golden hamster Binding pIC50 = 8.1 8.1 - 0
Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2Competitive inhibition of [125I]NKA binding to hamster urinary bladder Tachykinin receptor 2
ChEMBL 768 24 10 10 -1.5 CC(C)C[C@@H](CN[C@@H](Cc1ccccc1)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C 10.1021/jm00099a024
CHEMBL263852 213052 None 0 Rat Binding pIC50 = 8.1 8.1 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(C)(C)C)C(N)=O 10.1021/jm00037a009
CHEMBL2390989 212870 None 17 Human Binding pIC50 = 8.0 8.0 - 1
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.ejmech.2013.01.044
44319340 208371 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
CHEMBL84055 208371 None 0 Mouse Binding pIC50 = 8.0 8.0 - 0
Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.Binding affinity for NK2 receptor in HSKR-1 cells was determined by using [125 I ]-Iodohistidyl NKA.
ChEMBL 707 10 0 6 7.2 COc1cc(C(=O)N2CCC(CCN3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/S0960-894X(97)10013-0
44312000 207137 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL73839 207137 None 0 Human Binding pIC50 = 6.0 6.0 - 0
Inhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determinedInhibition of cloned human NK2 (Neurokinin 2) receptor, stably expressed in chinese hamster ovary (CHO) cells was determined
ChEMBL 551 8 3 3 4.6 CC(=O)NC1(c2ccccc2)CCN(C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N(C)Cc2ccccc2)CC1 10.1016/s0960-894x(98)00395-3
CHEMBL265573 213113 None 0 Rat Binding pIC50 = 6.0 6.0 - 0
Concentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranesConcentration required to inhibit the specific binding of [125I]NKA to Neurokinin-2 (NK-2) receptor in rat duodenum membranes
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)/C(=C\c1ccccc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(N)=O 10.1021/jm00037a009
448537 160344 None 54 Human Binding pIC50 = 5.0 5.0 -26 25
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 160344 None 54 Human Binding pIC50 = 5.0 5.0 -26 25
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
44384678 61391 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
CHEMBL176860 61391 None 0 Human Binding pIC50 = 7.0 7.0 - 0
Binding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKABinding affinity against human NK2 receptors from HSKR-1 cells using [125I]-Iodohistidyl NKA
ChEMBL 697 11 1 8 6.2 CCOC(=O)Oc1c(OC)cc(C(=O)N2CCC(CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc1OC 10.1016/0960-894X(96)00148-5
21121353 101528 None 0 Human Binding pIC50 = 7 7.0 - 3
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
CHEMBL297776 101528 None 0 Human Binding pIC50 = 7 7.0 - 3
Tested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligandTested for binding affinity against human NK-2 receptor transfected on CHO cells using [125I]-His] NKA as radioligand
ChEMBL 625 14 4 7 2.0 CC(=O)N[C@H](C(=O)N[C@H](Cc1cn(C=O)c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N(C)Cc1ccccc1)C(C)O 10.1021/jm00063a015
44270502 55269 None 0 Rat Binding pKd = 9.7 9.7 - 1
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 714 6 8 7 -0.3 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL16180 55269 None 0 Rat Binding pKd = 9.7 9.7 - 1
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 714 6 8 7 -0.3 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](C)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
118718707 115444 None 0 Rat Binding pKd = 6 6.0 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3350012 115444 None 0 Rat Binding pKd = 6 6.0 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718415 115415 None 0 Rat Binding pKd = 5 5.0 -2 2
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 820 12 8 10 -0.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349511 115415 None 0 Rat Binding pKd = 5 5.0 -2 2
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 820 12 8 10 -0.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718693 115440 None 0 Rat Binding pKd = 5 5.0 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349994 115440 None 0 Rat Binding pKd = 5 5.0 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 843 12 8 9 0.3 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718709 115445 None 0 Rat Binding pKd = 5 5.0 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 726 8 5 7 2.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3350016 115445 None 0 Rat Binding pKd = 5 5.0 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 726 8 5 7 2.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718515 115424 None 0 Rat Binding pKd = 4.9 4.9 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349686 115424 None 0 Rat Binding pKd = 4.9 4.9 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
118718571 115431 None 0 Rat Binding pKd = 4.8 4.8 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 747 12 6 8 0.7 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349799 115431 None 0 Rat Binding pKd = 4.8 4.8 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 747 12 6 8 0.7 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349619 213904 None 0 Rat Binding pKd = 4.8 4.8 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718570 115430 None 0 Rat Binding pKd = 6.7 6.7 63 2
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349798 115430 None 0 Rat Binding pKd = 6.7 6.7 63 2
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 786 12 7 8 1.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349990 213923 None 0 Rat Binding pKd = 4.7 4.7 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H]2CCCN2C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718513 115423 None 0 Rat Binding pKd = 5.6 5.6 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 797 11 6 8 2.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349683 115423 None 0 Rat Binding pKd = 5.6 5.6 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 797 11 6 8 2.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@](C)(c3cccc4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
118718694 115441 None 0 Rat Binding pKd = 4.6 4.6 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 804 12 7 9 -0.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349995 115441 None 0 Rat Binding pKd = 4.6 4.6 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 804 12 7 9 -0.2 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](Cc3ccccc3)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC1=O)C2=O 10.1021/jm00053a001
118718517 115426 None 0 Rat Binding pKd = 6.4 6.4 -1 3
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
CHEMBL3349688 115426 None 0 Rat Binding pKd = 6.4 6.4 -1 3
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 800 12 6 8 1.5 CSCC[C@@H]1NC(=O)[C@H](CC(C)C)N2C=C[C@@H](NC(=O)[C@H](Cc3ccccc3)N(C)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CCC(N)=O)NC1=O)C2=O 10.1021/jm00053a001
44270503 98832 None 0 Rat Binding pKd = 8.3 8.3 - 1
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 908 10 12 13 -2.8 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL278223 98832 None 0 Rat Binding pKd = 8.3 8.3 - 1
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL 908 10 12 13 -2.8 CC(C)C[C@@H]1NC(=O)[C@@H]2CNC(=O)C[C@H](NC(=O)[C@H](CSCC3O[C@@H](O)C(O)[C@H](O)[C@H]3O)CNC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL334721 213858 None 1 Rat Binding pKd = 8.2 8.2 -9 3
pA2 value against Tachykinin receptor 2 in rat vas deferenspA2 value against Tachykinin receptor 2 in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1016/s0960-894x(98)00178-4
CHEMBL3349531 213884 None 0 Rat Binding pKd = 6.2 6.2 - 1
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
CHEMBL3349620 213905 None 8 Rat Binding pKd = 8.1 8.1 251 3
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCC(N)=O)NC1=O 10.1021/jm00053a001
118718516 115425 None 0 Rat Binding pKd = 5.1 5.1 -79 3
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
CHEMBL3349687 115425 None 0 Rat Binding pKd = 5.1 5.1 -79 3
Inhibition of eledoisin binding to NK-2 receptor in rat vas deferensInhibition of eledoisin binding to NK-2 receptor in rat vas deferens
ChEMBL 1599 27 12 16 2.8 CC(C)C[C@H]1C(=O)N[C@@H](CCSCCSCC[C@@H]2NC(=O)[C@H](CC(C)C)N3C=C[C@@H](NC(=O)[C@H](Cc4ccccc4)N(C)C(=O)[C@@H](Cc4c[nH]c5ccccc45)NC(=O)[C@H](CCC(N)=O)NC2=O)C3=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N(C)[C@@H](Cc2ccccc2)C(=O)N[C@@H]2C=CN1C2=O 10.1021/jm00053a001
9831504 85070 None 0 Human Binding pKi = 10.6 10.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 696 8 6 6 2.0 O=C1C[C@@H](NC2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224081 85070 None 0 Human Binding pKi = 10.6 10.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 696 8 6 6 2.0 O=C1C[C@@H](NC2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
71449111 78926 None 0 Human Binding pKi = 10.3 10.3 6 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 78926 None 0 Human Binding pKi = 10.3 10.3 6 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44421489 168831 None 0 Human Binding pKi = 10.3 10.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 742 9 7 7 0.8 NS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL436981 168831 None 0 Human Binding pKi = 10.3 10.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 742 9 7 7 0.8 NS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11433617 6773 None 0 Human Binding pKi = 10.3 10.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083850 6773 None 0 Human Binding pKi = 10.3 10.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
23625329 92872 None 0 Human Binding pKi = 10.3 10.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 664 11 3 6 5.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
CHEMBL243711 92872 None 0 Human Binding pKi = 10.3 10.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 664 11 3 6 5.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
11593070 93222 None 0 Human Binding pKi = 10.2 10.2 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 708 11 3 6 5.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Br)cc2s1 10.1021/jm070289w
CHEMBL244362 93222 None 0 Human Binding pKi = 10.2 10.2 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 708 11 3 6 5.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(Br)cc2s1 10.1021/jm070289w
23627059 151265 None 0 Human Binding pKi = 10.2 10.2 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 698 11 3 6 5.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(C(F)(F)F)cc2s1 10.1021/jm070289w
CHEMBL395972 151265 None 0 Human Binding pKi = 10.2 10.2 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 698 11 3 6 5.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(C(F)(F)F)cc2s1 10.1021/jm070289w
11366268 142092 None 0 Human Binding pKi = 10.2 10.2 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387506 142092 None 0 Human Binding pKi = 10.2 10.2 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
44421488 169113 None 0 Human Binding pKi = 10.2 10.2 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 741 9 6 7 1.6 CS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL439281 169113 None 0 Human Binding pKi = 10.2 10.2 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 741 9 6 7 1.6 CS(=O)(=O)N1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11527495 1968 None 19 Human Binding pKi = 10.1 10.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
2117 1968 None 19 Human Binding pKi = 10.1 10.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
CHEMBL266125 1968 None 19 Human Binding pKi = 10.1 10.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
DB12042 1968 None 19 Human Binding pKi = 10.1 10.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 11 3 6 5.2 O=C([C@H](NC(=O)C1(CCCC1)NC(=O)c1cc2c(s1)cc(cc2)C)Cc1ccccc1)NCC1CCN(CC1)CC1CCOCC1 10.1021/jm070289w
46889641 6781 None 0 Human Binding pKi = 10.1 10.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083858 6781 None 0 Human Binding pKi = 10.1 10.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237033 14203 None 0 Human Binding pKi = 10.1 10.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
CHEMBL1083974 14203 None 0 Human Binding pKi = 10.1 10.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
CHEMBL1198853 14203 None 0 Human Binding pKi = 10.1 10.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 359 7 1 4 1.9 N[C@@H](CCC(=O)N1CCN(CC2CCOCC2)CC1)Cc1ccccc1 10.1021/jm100176s
23627061 151270 None 0 Human Binding pKi = 10.0 10.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 701 14 3 7 5.8 CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL395974 151270 None 0 Human Binding pKi = 10.0 10.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 701 14 3 7 5.8 CCN(CC)c1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
2115 1847 None 14 Rat Binding pKi = 10 10.0 8 3
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
9953599 1847 None 14 Rat Binding pKi = 10 10.0 8 3
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL2110370 1847 None 14 Rat Binding pKi = 10 10.0 8 3
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
10508281 84817 None 0 Human Binding pKi = 10 10.0 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm0010217
CHEMBL223221 84817 None 0 Human Binding pKi = 10 10.0 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm0010217
10508281 84817 None 0 Human Binding pKi = 10 10.0 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm040832y
CHEMBL223221 84817 None 0 Human Binding pKi = 10 10.0 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm040832y
11239751 85205 None 0 Human Binding pKi = 10 10.0 1995 3
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL225297 85205 None 0 Human Binding pKi = 10 10.0 1995 3
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 10 7 8 -0.5 NS(=O)(=O)N1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11193639 143143 None 0 Human Binding pKi = 10 10.0 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 680 8 6 6 3.0 O=C1C[C@@H](NC2CCSCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389510 143143 None 0 Human Binding pKi = 10 10.0 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 680 8 6 6 3.0 O=C1C[C@@H](NC2CCSCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11445137 6802 None 0 Human Binding pKi = 10 10.0 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083879 6802 None 0 Human Binding pKi = 10 10.0 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10508281 84817 None 0 Human Binding pKi = 10 10.0 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm011127h
CHEMBL223221 84817 None 0 Human Binding pKi = 10 10.0 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 633 6 5 4 3.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CN1 10.1021/jm011127h
10122346 92267 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 652 11 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(c3ccccn3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242626 92267 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 652 11 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(c3ccccn3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
71452717 78929 None 0 Human Binding pKi = 9.9 9.9 5 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112925 78929 None 0 Human Binding pKi = 9.9 9.9 5 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 678 7 5 6 1.6 O=C1CC(C(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11388737 85062 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 691 7 5 6 1.7 CC(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL224003 85062 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 691 7 5 6 1.7 CC(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11764349 85100 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 9 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC(O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224374 85100 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 9 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC(O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236920 6786 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 629 12 2 5 7.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083863 6786 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 629 12 2 5 7.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237170 6792 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 640 12 2 5 6.7 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccc(F)cc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083869 6792 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 640 12 2 5 6.7 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccc(F)cc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
23626110 149794 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 640 12 4 7 2.0 NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
CHEMBL394780 149794 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 640 12 4 7 2.0 NS(=O)(=O)N1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
23627060 151267 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 660 12 3 7 4.9 COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL395973 151267 None 0 Human Binding pKi = 9.9 9.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 660 12 3 7 4.9 COc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
44302816 202821 None 0 Human Binding pKi = 9.8 9.8 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL59780 202821 None 0 Human Binding pKi = 9.8 9.8 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
5487475 89427 None 22 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL2370064 89427 None 22 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 903 20 7 8 2.4 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
9853827 85255 None 0 Human Binding pKi = 9.8 9.8 794 3
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225588 85255 None 0 Human Binding pKi = 9.8 9.8 794 3
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 790 10 6 8 1.5 O=C1C[C@@H](NC(=O)CN2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11216552 97015 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 678 8 5 6 2.7 CN(C1CCOCC1)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL266284 97015 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 678 8 5 6 2.7 CN(C1CCOCC1)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
10326920 143086 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389459 143086 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11411829 143144 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 712 8 6 7 1.7 O=C1C[C@@H](NC2CCS(=O)(=O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389511 143144 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 712 8 6 7 1.7 O=C1C[C@@H](NC2CCS(=O)(=O)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11228042 161830 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
CHEMBL413715 161830 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
46237171 6793 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083870 6793 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237301 6796 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccs5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083873 6796 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccs5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237302 6797 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccsc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083874 6797 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 6 6.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccsc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237445 6798 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 2 6 6.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccoc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083875 6798 None 0 Human Binding pKi = 9.8 9.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 2 6 6.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccoc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10326920 143086 None 0 Human Binding pKi = 9.8 9.8 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL389459 143086 None 0 Human Binding pKi = 9.8 9.8 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
11205343 85064 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 731 8 5 6 3.5 O=C1C[C@@H](N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224009 85064 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 731 8 5 6 3.5 O=C1C[C@@H](N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11285709 85220 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
CHEMBL225392 85220 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 6 6 5 2.8 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)CNC1=O 10.1021/jm040832y
44421490 142428 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 677 8 6 6 2.2 CN1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL388626 142428 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 677 8 6 6 2.2 CN1CCC(N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11228450 142873 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 733 8 5 7 2.3 O=C1C[C@@H](N2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL389279 142873 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 733 8 5 7 2.3 O=C1C[C@@H](N2CCC(N3CCOCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
9831546 207633 None 0 Human Binding pKi = 9.7 9.7 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78284 207633 None 0 Human Binding pKi = 9.7 9.7 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 698 12 1 6 5.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44307820 206093 None 0 Guinea pig Binding pKi = 9.7 9.7 1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67171 206093 None 0 Guinea pig Binding pKi = 9.7 9.7 1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
23626743 92626 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 4.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243496 92626 None 0 Human Binding pKi = 9.7 9.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 4.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
53318867 58500 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 639 12 3 6 4.5 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683146 58500 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 639 12 3 6 4.5 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1 10.1016/j.bmcl.2011.01.074
23627058 151263 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 648 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(F)cc2s1 10.1021/jm070289w
CHEMBL395971 151263 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 648 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccc(F)cc2s1 10.1021/jm070289w
11205157 85110 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 718 7 5 6 3.2 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224494 85110 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 718 7 5 6 3.2 O=C1C[C@@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11491634 171648 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 822 10 6 8 1.2 O=C1C[C@@H](NC(=O)CN2CCC(N3CC[S+]([O-])CC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL446450 171648 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 822 10 6 8 1.2 O=C1C[C@@H](NC(=O)CN2CCC(N3CC[S+]([O-])CC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46238093 6769 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 634 12 2 6 5.7 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2cc(Cl)ccc2o1 10.1021/jm100176s
CHEMBL1083846 6769 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 634 12 2 6 5.7 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2cc(Cl)ccc2o1 10.1021/jm100176s
46236387 6772 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 12 2 6 5.5 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2s1 10.1021/jm100176s
CHEMBL1083849 6772 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 12 2 6 5.5 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2s1 10.1021/jm100176s
46237038 6789 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083866 6789 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237300 6795 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccncc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083872 6795 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5ccncc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
10232332 93253 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
CHEMBL244566 93253 None 0 Human Binding pKi = 9.6 9.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccc(Cl)cc2s1 10.1021/jm070289w
44307819 102651 None 0 Guinea pig Binding pKi = 9.5 9.5 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL304106 102651 None 0 Guinea pig Binding pKi = 9.5 9.5 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307677 169367 None 0 Guinea pig Binding pKi = 9.5 9.5 1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL441252 169367 None 0 Guinea pig Binding pKi = 9.5 9.5 1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307757 205994 None 0 Guinea pig Binding pKi = 9.5 9.5 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66441 205994 None 0 Guinea pig Binding pKi = 9.5 9.5 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307758 206014 None 0 Guinea pig Binding pKi = 9.5 9.5 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66635 206014 None 0 Guinea pig Binding pKi = 9.5 9.5 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44383850 59958 None 0 Rat Binding pKi = 9.5 9.5 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 552 9 0 4 6.8 CC(=O)OC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL173203 59958 None 0 Rat Binding pKi = 9.5 9.5 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 552 9 0 4 6.8 CC(=O)OC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
44385292 131456 None 0 Rat Binding pKi = 9.5 9.5 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 572 10 0 5 7.2 CCN(CC(CCN1CCC(OC(C)=O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
CHEMBL368995 131456 None 0 Rat Binding pKi = 9.5 9.5 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 572 10 0 5 7.2 CCN(CC(CCN1CCC(OC(C)=O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
2115 1847 None 14 Human Binding pKi = 9.5 9.5 -8 3
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
9953599 1847 None 14 Human Binding pKi = 9.5 9.5 -8 3
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL2110370 1847 None 14 Human Binding pKi = 9.5 9.5 -8 3
Binding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cellsBinding affinity against Tachykinin receptor 2 of human expressed in chinese hamster ovary cells
ChEMBL 414 7 1 3 4.1 COC1(CCN(CC1)CCc1c[nH]c2c1cc(F)cc2)C[S@@](=O)c1ccccc1 10.1016/S0960-894X(01)80541-2
44301859 202268 None 0 Rat Binding pKi = 9.5 9.5 35481 2
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL59413 202268 None 0 Rat Binding pKi = 9.5 9.5 35481 2
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44577911 172356 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447439 172356 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1016/j.bmcl.2008.06.102
25071640 174503 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1cccc(Cl)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL455238 174503 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1cccc(Cl)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
71449111 78926 None 0 Human Binding pKi = 9.5 9.5 6 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112922 78926 None 0 Human Binding pKi = 9.5 9.5 6 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 759 8 5 6 3.3 O=C1CC(C(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11193706 10518 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL116812 10518 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11251435 85105 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 10 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC[C@H]2CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224426 85105 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 721 10 7 7 1.1 O=C1C[C@@H](NC(=O)CN2CCC[C@H]2CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11400251 143947 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 739 9 6 7 0.7 O=C1C[C@@H](NC(=O)CN2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL390168 143947 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 739 9 6 7 0.7 O=C1C[C@@H](NC(=O)CN2CC[S+]([O-])CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237960 6695 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1021/jm100176s
CHEMBL1083561 6695 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1021/jm100176s
46889640 6778 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 11 2 6 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083855 6778 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 11 2 6 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237299 6794 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccnc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083871 6794 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 623 12 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5cccnc5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236394 6800 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 9 4.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5nnn(C)n5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083877 6800 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 12 2 9 4.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5nnn(C)n5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236396 6801 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 618 15 2 6 5.8 CCOCCCN1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1083878 6801 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 618 15 2 6 5.8 CCOCCCN1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
46236516 6870 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 12 2 6 4.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084160 6870 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 12 2 6 4.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44577911 172356 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1021/jm100176s
CHEMBL447439 172356 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 664 12 3 5 5.7 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)cc2)cc1 10.1021/jm100176s
11193706 10518 None 0 Human Binding pKi = 9.5 9.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL116812 10518 None 0 Human Binding pKi = 9.5 9.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 707 9 6 7 1.0 O=C1C[C@@H](NC(=O)CN2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
53324157 58505 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2011.01.074
CHEMBL1683151 58505 None 0 Human Binding pKi = 9.5 9.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 610 12 2 5 5.4 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2011.01.074
9961315 117988 None 0 Human Binding pKi = 9.5 9.5 -2 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
CHEMBL340326 117988 None 0 Human Binding pKi = 9.5 9.5 -2 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) in mouse erythroleukemia cells
ChEMBL 661 10 0 5 7.9 COc1ccc(C2CCN(CC[C@H](CN(C)C(=O)c3cc(C#N)cc4ccccc34)c3ccc(Cl)c(Cl)c3)CC2)c([S@+](C)[O-])c1 10.1021/jm020094i
23626900 151272 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cccc(Cl)c2s1 10.1021/jm070289w
CHEMBL395975 151272 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cccc(Cl)c2s1 10.1021/jm070289w
44434191 149924 None 0 Human Binding pKi = 9.4 9.4 501 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL394889 149924 None 0 Human Binding pKi = 9.4 9.4 501 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 588 11 3 5 5.4 CC1CCCCN1CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
11274473 85059 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 744 13 11 10 -1.4 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223993 85059 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 744 13 11 10 -1.4 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10876489 85238 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225475 85238 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11331994 169125 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 5 6 1.8 CN1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL439377 169125 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 5 6 1.8 CN1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
46238232 6771 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 614 12 2 6 5.3 Cc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
CHEMBL1083848 6771 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 614 12 2 6 5.3 Cc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
46236510 6803 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)c5cccn5C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083880 6803 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 639 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)c5cccn5C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236512 6868 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 10 2 6 4.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084158 6868 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 10 2 6 4.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44343142 155949 None 0 Human Binding pKi = 9.4 9.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL406024 155949 None 0 Human Binding pKi = 9.4 9.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 788 10 6 7 2.6 O=C1C[C@@H](NC(=O)CN2CCC(N3CCCCC3)CC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
2106 3546 None 5 Human Binding pKi = 9.4 9.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9875034 3546 None 5 Human Binding pKi = 9.4 9.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
CHEMBL77023 3546 None 5 Human Binding pKi = 9.4 9.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 711 12 1 6 6.4 CO/N=C(/[C@@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)N1CCC[C@@H](C1=O)CC(=O)NC)\CN(C(=O)c1cc(Cl)cc(c1)Cl)C 10.1016/s0960-894x(02)00462-6
9810544 207250 None 0 Human Binding pKi = 9.4 9.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL74956 207250 None 0 Human Binding pKi = 9.4 9.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 12 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)(C)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
155551678 175536 None 0 Human Binding pKi = 9.4 9.4 -1 3
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
CHEMBL4576324 175536 None 0 Human Binding pKi = 9.4 9.4 -1 3
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 697 12 1 6 6.9 CNC(=O)C[C@H]1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1021/acs.jmedchem.9b00017
44307898 203930 None 0 Guinea pig Binding pKi = 9.4 9.4 1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL60504 203930 None 0 Guinea pig Binding pKi = 9.4 9.4 1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44307679 205975 None 0 Guinea pig Binding pKi = 9.4 9.4 1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL66332 205975 None 0 Guinea pig Binding pKi = 9.4 9.4 1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
23625950 142968 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 578 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCSCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL389355 142968 None 0 Human Binding pKi = 9.4 9.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 578 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCSCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
104974 3475 None 25 Bovine Binding pKi = 9.3 9.3 -1 7
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
2111 3475 None 25 Bovine Binding pKi = 9.3 9.3 -1 7
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
3481 3475 None 25 Bovine Binding pKi = 9.3 9.3 -1 7
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
CHEMBL308148 3475 None 25 Bovine Binding pKi = 9.3 9.3 -1 7
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
DB06660 3475 None 25 Bovine Binding pKi = 9.3 9.3 -1 7
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/j.bmcl.2004.06.053
44315483 96652 None 0 Human Binding pKi = 9.3 9.3 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL263243 96652 None 0 Human Binding pKi = 9.3 9.3 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 13 2 7 5.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN([C@H](CO)C(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831707 207485 None 0 Human Binding pKi = 9.3 9.3 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76965 207485 None 0 Human Binding pKi = 9.3 9.3 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 718 11 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(c3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9853636 207908 None 0 Human Binding pKi = 9.3 9.3 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL80355 207908 None 0 Human Binding pKi = 9.3 9.3 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 762 14 1 7 5.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CCNS(C)(=O)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
102023780 120811 None 0 Human Binding pKi = 9.3 9.3 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10417302 120811 None 0 Human Binding pKi = 9.3 9.3 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380072 120811 None 0 Human Binding pKi = 9.3 9.3 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355041 120811 None 0 Human Binding pKi = 9.3 9.3 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
104974 3475 None 25 Human Binding pKi = 9.3 9.3 1 7
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
2111 3475 None 25 Human Binding pKi = 9.3 9.3 1 7
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
3481 3475 None 25 Human Binding pKi = 9.3 9.3 1 7
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
CHEMBL308148 3475 None 25 Human Binding pKi = 9.3 9.3 1 7
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
DB06660 3475 None 25 Human Binding pKi = 9.3 9.3 1 7
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/s0960-894x(00)00463-7
104974 3475 None 25 Rat Binding pKi = 9.3 9.3 -7 7
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2111 3475 None 25 Rat Binding pKi = 9.3 9.3 -7 7
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
3481 3475 None 25 Rat Binding pKi = 9.3 9.3 -7 7
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL308148 3475 None 25 Rat Binding pKi = 9.3 9.3 -7 7
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
DB06660 3475 None 25 Rat Binding pKi = 9.3 9.3 -7 7
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
9843958 203249 None 1 Rat Binding pKi = 9.3 9.3 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL60064 203249 None 1 Rat Binding pKi = 9.3 9.3 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44577907 172554 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447971 172554 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44421494 142095 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 1068 19 17 20 -5.8 O=C1C[C@@H](NC[C@H](O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387542 142095 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 1068 19 17 20 -5.8 O=C1C[C@@H](NC[C@H](O)[C@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O[C@@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11468591 143945 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 748 10 7 7 0.9 NC(=O)C1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL390167 143945 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 748 10 7 7 0.9 NC(=O)C1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
46237957 6694 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 636 13 2 5 5.9 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm100176s
CHEMBL1083560 6694 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 636 13 2 5 5.9 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm100176s
46236647 6777 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083854 6777 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236798 6784 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](/C=C/CN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083861 6784 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 628 11 2 6 5.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](/C=C/CN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
11239162 6788 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 13 2 6 6.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083865 6788 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 645 13 2 6 6.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236514 6869 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 681 12 2 7 4.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084159 6869 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 681 12 2 7 4.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236655 6872 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 638 12 2 6 5.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)C(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084162 6872 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 638 12 2 6 5.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(=O)(=O)C(C)C)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
2110 2969 None 33 Rat Binding pKi = 9.3 9.3 -1 6
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 2969 None 33 Rat Binding pKi = 9.3 9.3 -1 6
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 2969 None 33 Rat Binding pKi = 9.3 9.3 -1 6
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 2969 None 33 Rat Binding pKi = 9.3 9.3 -1 6
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 2969 None 33 Rat Binding pKi = 9.3 9.3 -1 6
Ability to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membraneAbility to displace [125I]NKA from Tachykinin receptor 2 in rat deodenum membrane
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
23626744 92629 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243498 92629 None 0 Human Binding pKi = 9.3 9.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
2109 4137 None 6 Human Binding pKi = 9.2 9.2 -5 3
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9852253 4137 None 6 Human Binding pKi = 9.2 9.2 -5 3
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
CHEMBL129683 4137 None 6 Human Binding pKi = 9.2 9.2 -5 3
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1016/s0960-894x(01)00572-8
9830361 181732 None 0 Human Binding pKi = 9.2 9.2 -1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47739 181732 None 0 Human Binding pKi = 9.2 9.2 -1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 538 7 1 4 7.1 C[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
9850582 199698 None 20 Human Binding pKi = 9.2 9.2 -1 6
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56835 199698 None 20 Human Binding pKi = 9.2 9.2 -1 6
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44307741 206245 None 0 Guinea pig Binding pKi = 9.2 9.2 -15 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68234 206245 None 0 Guinea pig Binding pKi = 9.2 9.2 -15 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL334721 213858 None 1 Human Binding pKi = 9.2 9.2 9 3
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL None None None CSCC[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
10281234 92268 None 0 Human Binding pKi = 9.2 9.2 38 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL242631 92268 None 0 Human Binding pKi = 9.2 9.2 38 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
71458042 78927 None 0 Human Binding pKi = 9.2 9.2 1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112923 78927 None 0 Human Binding pKi = 9.2 9.2 1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 692 8 5 6 2.0 O=C1C[C@@H](CC(=O)N2CCOCC2)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44421493 85060 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223994 85060 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237825 6693 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 650 13 2 5 6.3 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2)cc1 10.1021/jm100176s
CHEMBL1083559 6693 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 650 13 2 5 6.3 Cc1ccc(-c2ccc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2)cc1 10.1021/jm100176s
46238229 6770 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 13 2 7 5.0 COc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
CHEMBL1083847 6770 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 13 2 7 5.0 COc1ccc2oc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)cc2c1 10.1021/jm100176s
9874027 6774 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083851 6774 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](CCCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237037 6787 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 631 12 2 6 6.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083864 6787 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 631 12 2 6 6.1 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](COCC4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237168 6790 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 609 11 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083867 6790 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 609 11 2 6 6.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ccccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46889663 6871 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 611 11 3 6 3.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(N)(=O)=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084161 6871 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 611 11 3 6 3.6 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(S(N)(=O)=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237698 6873 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 624 12 2 6 4.7 CCS(=O)(=O)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1084163 6873 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 624 12 2 6 4.7 CCS(=O)(=O)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
46238091 7012 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 600 12 2 6 5.0 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2o1 10.1021/jm100176s
CHEMBL1084765 7012 None 0 Human Binding pKi = 9.2 9.2 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 600 12 2 6 5.0 O=C(NC1(C(=O)N[C@@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2o1 10.1021/jm100176s
2109 4137 None 6 Human Binding pKi = 9.2 9.2 -5 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
9852253 4137 None 6 Human Binding pKi = 9.2 9.2 -5 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
CHEMBL129683 4137 None 6 Human Binding pKi = 9.2 9.2 -5 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 631 9 0 4 7.9 N#Cc1cc2ccccc2c(c1)C(=O)N(C[C@H](c1ccc(c(c1)Cl)Cl)CCN1CCC(CC1)c1ccccc1[S@@](=O)C)C 10.1021/jm020094i
10281234 92268 None 0 Human Binding pKi = 9.2 9.2 38 2
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242631 92268 None 0 Human Binding pKi = 9.2 9.2 38 2
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 562 11 3 6 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9852630 207311 None 0 Human Binding pKi = 9.2 9.2 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75598 207311 None 0 Human Binding pKi = 9.2 9.2 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 655 10 0 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9896757 207439 None 0 Human Binding pKi = 9.2 9.2 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76580 207439 None 0 Human Binding pKi = 9.2 9.2 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 732 12 0 6 7.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccccn3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9831075 207611 None 0 Human Binding pKi = 9.2 9.2 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78132 207611 None 0 Human Binding pKi = 9.2 9.2 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 657 10 1 6 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380396 57737 None 0 Human Binding pKi = 9.2 9.2 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166921 57737 None 0 Human Binding pKi = 9.2 9.2 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 3 7 6.4 CN(C/C(=N\OCC(=N)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9872857 181860 None 0 Human Binding pKi = 9.2 9.2 2 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 498 7 1 4 6.1 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
CHEMBL47775 181860 None 0 Human Binding pKi = 9.2 9.2 2 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 498 7 1 4 6.1 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
44307773 102415 None 0 Guinea pig Binding pKi = 9.2 9.2 -17 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL303803 102415 None 0 Guinea pig Binding pKi = 9.2 9.2 -17 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 779 13 0 7 7.6 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)C3CCN(C)CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
2089 2766 None 25 Human Binding pKi = 9.2 9.2 102 5
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3795 2766 None 25 Human Binding pKi = 9.2 9.2 102 5
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311311 2766 None 25 Human Binding pKi = 9.2 9.2 102 5
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL217406 2766 None 25 Human Binding pKi = 9.2 9.2 102 5
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10303894 86037 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 588 12 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)s1 10.1021/jm070289w
CHEMBL230424 86037 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 588 12 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)s1 10.1021/jm070289w
23626412 149241 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL394350 149241 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10166998 166776 None 0 Human Binding pKi = 9.1 9.1 125 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL428203 166776 None 0 Human Binding pKi = 9.1 9.1 125 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577893 170120 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 13 3 6 4.8 CCSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL444253 170120 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 13 3 6 4.8 CCSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577903 170148 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL444289 170148 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
11285716 142124 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387698 142124 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL406287 142124 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236796 6783 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083860 6783 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 11 2 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(C(=O)N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237169 6791 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 11 2 7 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ncccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083868 6791 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 610 11 2 7 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(c5ncccn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46889664 6874 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 672 11 2 6 5.1 CC/N=C(\N1CCOCC1)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
CHEMBL1084164 6874 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 672 11 2 6 5.1 CC/N=C(\N1CCOCC1)N1CCN(CCC[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccc(C)cc4s3)CCCC2)CC1 10.1021/jm100176s
11285716 142124 None 0 Human Binding pKi = 9.1 9.1 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL387698 142124 None 0 Human Binding pKi = 9.1 9.1 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL406287 142124 None 0 Human Binding pKi = 9.1 9.1 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 650 7 5 6 1.9 O=C1C[C@H](N2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
9810434 104438 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL310273 104438 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 1 6 6.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(C)(C)O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
101195489 155710 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9875056 155710 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL404599 155710 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 713 12 3 7 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=N)NO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9917970 207411 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76437 207411 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 683 11 0 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(C(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380206 57789 None 0 Human Binding pKi = 9.1 9.1 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166961 57789 None 0 Human Binding pKi = 9.1 9.1 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 658 11 0 5 7.3 CN(C/C(=N\OCF)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380448 120344 None 0 Human Binding pKi = 9.1 9.1 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352588 120344 None 0 Human Binding pKi = 9.1 9.1 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 670 12 1 6 6.4 CN(C/C(=N\OCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10370066 172881 None 1 Human Binding pKi = 9.1 9.1 1 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 540 7 1 5 5.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL45129 172881 None 1 Human Binding pKi = 9.1 9.1 1 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 540 7 1 5 5.9 C[C@H](NC(=O)c1c(CN2CCC(N3CCOCC3)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
44307821 102169 None 0 Guinea pig Binding pKi = 9.1 9.1 -4 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL302329 102169 None 0 Guinea pig Binding pKi = 9.1 9.1 -4 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@@H](CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 206229 None 0 Guinea pig Binding pKi = 9.1 9.1 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 206229 None 0 Guinea pig Binding pKi = 9.1 9.1 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
23626108 79159 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 11 4 6 3.9 C[C@H]1CN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)C[C@@H](C)N1 10.1021/jm070289w
CHEMBL2113292 79159 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 11 4 6 3.9 C[C@H]1CN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)C[C@@H](C)N1 10.1021/jm070289w
54537190 79674 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2115073 79674 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CC[C@H](CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23625325 143435 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL389744 143435 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 630 11 3 6 5.1 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23626568 92264 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242619 92264 None 0 Human Binding pKi = 9.1 9.1 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9961936 103144 None 0 Human Binding pKi = 9.1 9.1 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307498 103144 None 0 Human Binding pKi = 9.1 9.1 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 723 12 1 8 5.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3nn[nH]n3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
9961955 172876 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL451235 172876 None 0 Human Binding pKi = 9.1 9.1 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 726 11 0 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337354 5459 None 0 Human Binding pKi = 9.1 9.1 58 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
CHEMBL107469 5459 None 0 Human Binding pKi = 9.1 9.1 58 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 656 8 2 7 5.3 CC(=O)Nc1nc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cs1 10.1016/s0960-894x(02)00645-5
44307678 201131 None 0 Guinea pig Binding pKi = 9.1 9.1 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL57993 201131 None 0 Guinea pig Binding pKi = 9.1 9.1 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CC[C@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44384522 60097 None 0 Rat Binding pKi = 9.1 9.1 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 538 10 0 3 7.3 CCOC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL173841 60097 None 0 Rat Binding pKi = 9.1 9.1 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 538 10 0 3 7.3 CCOC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
44351946 117433 None 0 Human Binding pKi = 9.0 9.0 1778 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
CHEMBL339767 117433 None 0 Human Binding pKi = 9.0 9.0 1778 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 568 8 0 3 7.3 CCN1C(=O)c2ccccc2[C@H]1[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm020094i
18964186 206762 None 0 Bovine Binding pKi = 9 9.0 -3 3
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/j.bmcl.2004.06.053
CHEMBL71397 206762 None 0 Bovine Binding pKi = 9 9.0 -3 3
Binding affinity against bovine Tachykinin receptor 2Binding affinity against bovine Tachykinin receptor 2
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/j.bmcl.2004.06.053
153996 112731 None 0 Human Binding pKi = 9 9.0 -3 3
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL330366 112731 None 0 Human Binding pKi = 9 9.0 -3 3
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
CHEMBL539021 112731 None 0 Human Binding pKi = 9 9.0 -3 3
Binding affinity against human cloned Tachykinin receptor 2 expressed in MEL cellsBinding affinity against human cloned Tachykinin receptor 2 expressed in MEL cells
ChEMBL 639 10 1 6 5.7 COc1cc(C(=O)N2CC[C@](CCN3CCC(C(N)=O)(c4ccccc4)CC3)(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(01)00572-8
15508105 207289 None 0 Human Binding pKi = 9 9.0 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75422 207289 None 0 Human Binding pKi = 9 9.0 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 675 10 1 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10432325 17962 None 0 Rat Binding pKi = 9 9.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL126050 17962 None 0 Rat Binding pKi = 9 9.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44281649 109076 None 0 Human Binding pKi = 9 9.0 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32124 109076 None 0 Human Binding pKi = 9 9.0 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 625 11 1 7 6.0 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281332 112973 None 0 Human Binding pKi = 9 9.0 100 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33106 112973 None 0 Human Binding pKi = 9 9.0 100 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 588 11 1 8 6.4 CO/N=C(\COCc1noc(C(C)(C)C)n1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
5769 3524 None 5 Human Binding pKi = 9 9.0 194 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
9806459 3524 None 5 Human Binding pKi = 9 9.0 194 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
CHEMBL295770 3524 None 5 Human Binding pKi = 9 9.0 194 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 512 6 1 4 6.5 O=C(c1c(CN2CCC(CC2)N2CCCCC2)c(nc2c1cccc2)c1ccccc1)N[C@H](C(C)(C)C)C 10.1021/jm000501v
44434198 149911 None 0 Human Binding pKi = 9 9.0 25 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL394878 149911 None 0 Human Binding pKi = 9 9.0 25 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 4.0 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCc3ccccc32)CC1 10.1016/j.bmcl.2007.06.053
44577908 171180 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 13 3 6 4.8 CSc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL445730 171180 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 13 3 6 4.8 CSc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577898 171405 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1cccc(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL446086 171405 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1cccc(F)c1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577906 172905 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL451374 172905 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1cccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577900 188993 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccccc1Cl)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL507334 188993 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccccc1Cl)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
11764212 85166 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL224888 85166 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 664 8 6 6 2.3 O=C1C[C@H](NC2CCOCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46237296 6775 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CN5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083852 6775 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 630 12 2 6 5.8 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CN5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236392 6799 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 3 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5c[nH]cn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083876 6799 None 0 Human Binding pKi = 9 9.0 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 612 12 3 6 5.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(Cc5c[nH]cn5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
9875181 171446 None 0 Guinea pig Binding pKi = 9 9.0 -7 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL446146 171446 None 0 Guinea pig Binding pKi = 9 9.0 -7 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 725 12 0 6 6.7 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N(C)C)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9810835 206033 None 0 Guinea pig Binding pKi = 9 9.0 -7 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66763 206033 None 0 Guinea pig Binding pKi = 9 9.0 -7 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 767 12 0 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CCOCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9874206 206229 None 0 Guinea pig Binding pKi = 9 9.0 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL68060 206229 None 0 Guinea pig Binding pKi = 9 9.0 -1 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44385249 61224 None 0 Rat Binding pKi = 9 9.0 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccsc1 10.1016/S0960-894X(00)80694-0
CHEMBL176588 61224 None 0 Rat Binding pKi = 9 9.0 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccsc1 10.1016/S0960-894X(00)80694-0
18964186 206762 None 0 Rat Binding pKi = 9 9.0 -3 3
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL71397 206762 None 0 Rat Binding pKi = 9 9.0 -3 3
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 510 8 1 3 6.2 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
23626413 92266 None 0 Human Binding pKi = 9.0 9.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 10 3 6 3.0 CN1CCN(C(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
CHEMBL242625 92266 None 0 Human Binding pKi = 9.0 9.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 589 10 3 6 3.0 CN1CCN(C(=O)CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1021/jm070289w
44315298 103166 None 0 Human Binding pKi = 9.0 9.0 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307733 103166 None 0 Human Binding pKi = 9.0 9.0 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 721 12 0 6 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccoc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44337208 5241 None 0 Human Binding pKi = 9.0 9.0 38 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106300 5241 None 0 Human Binding pKi = 9.0 9.0 38 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337207 7832 None 0 Human Binding pKi = 9.0 9.0 10 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108955 7832 None 0 Human Binding pKi = 9.0 9.0 10 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
23626569 149552 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL394607 149552 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 659 11 3 7 3.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC(=O)N2CCN(C3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9831674 104466 None 0 Human Binding pKi = 8.9 8.9 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL310334 104466 None 0 Human Binding pKi = 8.9 8.9 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 712 12 1 6 5.9 CNC(=O)CN1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
44315370 207297 None 0 Human Binding pKi = 8.9 8.9 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75479 207297 None 0 Human Binding pKi = 8.9 8.9 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 789 14 0 7 7.9 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(CC(=O)OCc3ccccc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315297 207325 None 0 Human Binding pKi = 8.9 8.9 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
CHEMBL75698 207325 None 0 Human Binding pKi = 8.9 8.9 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 833 15 1 8 8.0 CCOC(=O)[C@@H](Cc1ccc(O)cc1)N1CCCN(C2CCN(CC[C@@H](/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00462-6
44315299 207469 None 0 Human Binding pKi = 8.9 8.9 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76823 207469 None 0 Human Binding pKi = 8.9 8.9 1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 737 12 0 6 8.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(N2CCCN(Cc3ccsc3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10792233 176520 None 0 Human Binding pKi = 8.9 8.9 1 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 526 7 1 4 5.9 CC(C)C(=O)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
CHEMBL45961 176520 None 0 Human Binding pKi = 8.9 8.9 1 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 526 7 1 4 5.9 CC(C)C(=O)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)N[C@@H](C)C2CCCCC2)CC1 10.1021/jm000501v
104974 3475 None 25 Golden hamster Binding pKi = 8.9 8.9 -3 7
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2111 3475 None 25 Golden hamster Binding pKi = 8.9 8.9 -3 7
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
3481 3475 None 25 Golden hamster Binding pKi = 8.9 8.9 -3 7
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL308148 3475 None 25 Golden hamster Binding pKi = 8.9 8.9 -3 7
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
DB06660 3475 None 25 Golden hamster Binding pKi = 8.9 8.9 -3 7
The compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranesThe compound was evaluated for the inhibition of [125I]NKA binding to neurokinin NK2 receptor from hamster urinary bladder membranes
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(CCN(CC1)CC[C@@H](c1ccc(c(c1)Cl)Cl)CN(C(=O)c1ccccc1)C)c1ccccc1 10.1016/S0960-894X(00)80694-0
2089 2766 None 25 Human Binding pKi = 8.9 8.9 102 5
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
3795 2766 None 25 Human Binding pKi = 8.9 8.9 102 5
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
5311311 2766 None 25 Human Binding pKi = 8.9 8.9 102 5
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
CHEMBL217406 2766 None 25 Human Binding pKi = 8.9 8.9 102 5
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL None None None None 10.1021/jm401823z
9887650 16658 None 0 Rat Binding pKi = 8.9 8.9 1 5
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 16658 None 0 Rat Binding pKi = 8.9 8.9 1 5
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10476440 117066 None 0 Rat Binding pKi = 8.9 8.9 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 2 3.9 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL338825 117066 None 0 Rat Binding pKi = 8.9 8.9 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 2 3.9 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10046881 118543 None 0 Rat Binding pKi = 8.9 8.9 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 405 5 1 2 4.4 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL341357 118543 None 0 Rat Binding pKi = 8.9 8.9 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 405 5 1 2 4.4 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
10121831 89473 None 0 Human Binding pKi = 8.9 8.9 158 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237097 89473 None 0 Human Binding pKi = 8.9 8.9 158 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434196 149312 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394418 149312 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434203 149315 None 0 Human Binding pKi = 8.9 8.9 158 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394420 149315 None 0 Human Binding pKi = 8.9 8.9 158 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.5 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577901 173564 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccc(Cl)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL452960 173564 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 634 12 3 5 4.8 O=C(/C=C/c1ccc(Cl)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577902 188437 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL500797 188437 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
11480157 168810 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL436804 168810 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 906 16 14 15 -3.6 O=C1C[C@@H](NC[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
46236649 6779 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 12 2 6 6.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083856 6779 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 644 12 2 6 6.3 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(N(C)C5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
44337355 5348 None 0 Human Binding pKi = 8.9 8.9 26 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106877 5348 None 0 Human Binding pKi = 8.9 8.9 26 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 581 7 2 4 5.2 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4cc[nH]c4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337174 7885 None 0 Human Binding pKi = 8.9 8.9 11 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
CHEMBL108997 7885 None 0 Human Binding pKi = 8.9 8.9 11 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 5.8 CC(=O)Nc1ccc(CN2CCC(NCC(=O)N3CCN(C(=O)c4cc(C)cc(C)c4)C[C@H]3c3ccc(Cl)c(Cl)c3)CC2)cc1 10.1016/s0960-894x(02)00645-5
22861435 169600 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N\O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL443264 169600 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N\O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44302497 161822 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1095 24 8 14 2.9 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL413650 161822 None 0 Human Binding pKi = 8.9 8.9 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1095 24 8 14 2.9 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
118724118 116469 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1095 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360196 116469 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1095 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
23625476 96993 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 655 11 3 7 4.8 N#Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
CHEMBL266108 96993 None 0 Human Binding pKi = 8.9 8.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 655 11 3 7 4.8 N#Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)C(=O)NCC4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm070289w
44380526 58345 None 0 Human Binding pKi = 8.9 8.9 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168272 58345 None 0 Human Binding pKi = 8.9 8.9 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 665 11 0 6 6.9 CN(C/C(=N\OCC#N)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
18964216 59911 None 0 Rat Binding pKi = 8.9 8.9 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
CHEMBL173008 59911 None 0 Rat Binding pKi = 8.9 8.9 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 516 8 1 4 6.3 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccs1 10.1016/S0960-894X(00)80694-0
44302414 82482 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1110 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL217548 82482 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1110 25 8 14 3.3 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
190884 116470 None 6 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1110 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360197 116470 None 6 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1110 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
44302394 97304 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1124 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL268783 97304 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1124 26 8 14 3.7 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)c1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
118724119 116471 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1174 30 9 14 4.8 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360198 116471 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1174 30 9 14 4.8 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
44315369 103074 None 0 Human Binding pKi = 8.8 8.8 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306952 103074 None 0 Human Binding pKi = 8.8 8.8 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 10 0 7 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(C)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380091 120785 None 0 Human Binding pKi = 8.8 8.8 -2 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354772 120785 None 0 Human Binding pKi = 8.8 8.8 -2 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 1 6 6.8 CN(C/C(=N\OCCCO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10744541 101397 None 0 Human Binding pKi = 8.8 8.8 -1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 520 8 1 4 6.6 CC(C)[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL296857 101397 None 0 Human Binding pKi = 8.8 8.8 -1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 520 8 1 4 6.6 CC(C)[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44385289 61387 None 0 Rat Binding pKi = 8.8 8.8 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 560 8 1 3 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc2ccccc12 10.1016/S0960-894X(00)80694-0
CHEMBL176853 61387 None 0 Rat Binding pKi = 8.8 8.8 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 560 8 1 3 7.4 CN(CC(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cccc2ccccc12 10.1016/S0960-894X(00)80694-0
10232331 93224 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cc(Cl)ccc2s1 10.1021/jm070289w
CHEMBL244364 93224 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2cc(Cl)ccc2s1 10.1021/jm070289w
10342250 16941 None 0 Rat Binding pKi = 8.8 8.8 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 423 7 2 3 3.7 CC(=O)N(Cc1ccccc1)CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
CHEMBL125310 16941 None 0 Rat Binding pKi = 8.8 8.8 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 423 7 2 3 3.7 CC(=O)N(Cc1ccccc1)CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
10477484 17280 None 0 Rat Binding pKi = 8.8 8.8 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc(F)c1 10.1021/jm00019a006
CHEMBL125696 17280 None 0 Rat Binding pKi = 8.8 8.8 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccc(F)c1 10.1021/jm00019a006
10722305 110375 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm0010217
CHEMBL323884 110375 None 0 Human Binding pKi = 8.8 8.8 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm0010217
44434195 88628 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL235574 88628 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44434202 152259 None 0 Human Binding pKi = 8.8 8.8 125 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL396827 152259 None 0 Human Binding pKi = 8.8 8.8 125 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.3 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
44577905 171754 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL446604 171754 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 614 12 3 5 4.4 Cc1ccccc1/C=C/C(=O)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44374556 52747 None 0 Human Binding pKi = 8.8 8.8 1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159449 52747 None 0 Human Binding pKi = 8.8 8.8 1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
44374427 54809 None 0 Human Binding pKi = 8.8 8.8 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL161242 54809 None 0 Human Binding pKi = 8.8 8.8 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 765 12 6 8 0.9 O=C1CC(C(=O)N2CCN(CCOCCO)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11491576 84932 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 649 7 6 6 1.4 O=C1C[C@@H](N2CCNCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL223644 84932 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 649 7 6 6 1.4 O=C1C[C@@H](N2CCNCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
11343418 85106 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 720 9 6 7 0.9 CN1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL224427 85106 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 720 9 6 7 0.9 CN1CCN(CC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44421491 137357 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 882 13 11 11 -1.5 CC(=O)N[C@H]1[C@H](NC(=O)CCC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O 10.1021/jm040832y
CHEMBL375213 137357 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 882 13 11 11 -1.5 CC(=O)N[C@H]1[C@H](NC(=O)CCC(=O)N[C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)O[C@H](CO)[C@@H](O)[C@@H]1O 10.1021/jm040832y
11479743 142125 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 7 5 5 3.0 O=C1C[C@@H](N2CCCCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL387699 142125 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 648 7 5 5 3.0 O=C1C[C@@H](N2CCCCC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10303737 86010 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 582 12 3 5 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm070289w
CHEMBL230324 86010 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 582 12 3 5 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(-c2ccccc2)cc1 10.1021/jm070289w
118724120 116472 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1181 29 9 15 3.2 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNCC(=O)Nc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
CHEMBL3360199 116472 None 0 Human Binding pKi = 8.8 8.8 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1181 29 9 15 3.2 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNCC(=O)Nc1ccc([N+](=O)[O-])c2nonc12)NC(=O)c1ccccc1)C(N)=O 10.1021/jm401823z
10722305 110375 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm011127h
CHEMBL323884 110375 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 601 6 5 4 2.8 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(F)c(F)c2)CN1 10.1021/jm011127h
44343144 164115 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 662 9 7 8 0.8 O=C1C[C@H](NCc2nn[nH]n2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL420859 164115 None 0 Human Binding pKi = 8.8 8.8 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 662 9 7 8 0.8 O=C1C[C@H](NCc2nn[nH]n2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
9939307 205944 None 0 Human Binding pKi = 8.8 8.8 2 4
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL66106 205944 None 0 Human Binding pKi = 8.8 8.8 2 4
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10840329 117029 None 0 Human Binding pKi = 8.8 8.8 -1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL33868 117029 None 0 Human Binding pKi = 8.8 8.8 -1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCN(C3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44315390 207500 None 0 Human Binding pKi = 8.8 8.8 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL77042 207500 None 0 Human Binding pKi = 8.8 8.8 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 733 12 1 8 7.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380062 120828 None 0 Human Binding pKi = 8.8 8.8 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355295 120828 None 0 Human Binding pKi = 8.8 8.8 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 740 14 2 6 6.7 CNC(=O)NCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
9850582 199698 None 20 Human Binding pKi = 8.8 8.8 -1 6
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56835 199698 None 20 Human Binding pKi = 8.8 8.8 -1 6
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 551 9 1 3 6.4 CC(=O)NC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315576 207703 None 0 Human Binding pKi = 8.7 8.7 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL78851 207703 None 0 Human Binding pKi = 8.7 8.7 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 12 0 9 7.2 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)OC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
23625179 83563 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL220365 83563 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 616 10 3 6 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23625180 92627 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 12 3 6 5.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243497 92627 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 644 12 3 6 5.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCC2CCN(CC3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
9829402 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm0010217
CHEMBL435324 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm0010217
44331128 107313 None 0 Human Binding pKi = 8.7 8.7 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 814 12 6 9 1.4 CN(C)CCN(C)C(=O)c1nccnc1C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(02)00539-5
CHEMBL316943 107313 None 0 Human Binding pKi = 8.7 8.7 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 814 12 6 9 1.4 CN(C)CCN(C)C(=O)c1nccnc1C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(02)00539-5
9829402 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(02)00539-5
CHEMBL435324 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(02)00539-5
44434194 88591 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 575 11 3 6 3.4 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL235353 88591 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 575 11 3 6 3.4 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434197 149314 None 0 Human Binding pKi = 8.7 8.7 1 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 149314 None 0 Human Binding pKi = 8.7 8.7 1 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434204 153657 None 0 Human Binding pKi = 8.7 8.7 50 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL398028 153657 None 0 Human Binding pKi = 8.7 8.7 50 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 3.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)Cc2ccccc2C1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577899 173062 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccc(F)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL451751 173062 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccc(F)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577904 188808 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL504342 188808 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 13 3 6 4.1 COc1ccc(/C=C/C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
9829402 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
CHEMBL435324 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1016/s0960-894x(01)00841-1
11332007 85115 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 14 11 10 -1.3 CC(=O)N[C@@H](CN[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/jm040832y
CHEMBL224532 85115 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 785 14 11 10 -1.3 CC(=O)N[C@@H](CN[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O)[C@@H](O)[C@H](O)[C@H](O)CO 10.1021/jm040832y
11377052 137958 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL376141 137958 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
9829402 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
CHEMBL435324 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm040832y
46889639 6776 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083853 6776 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.2 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCC(N5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46237442 6780 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 575 12 3 5 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CCO)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083857 6780 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 575 12 3 5 5.9 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCC(CCO)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
46236794 6782 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)CN4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083859 6782 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 602 10 2 6 5.0 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@H](Cc4ccccc4)CN4CCN(CC5CCOCC5)CC4)CCCC3)sc2c1 10.1021/jm100176s
46237575 6892 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 560 11 2 5 4.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1084251 6892 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 560 11 2 5 4.5 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCCN4CCN(C=O)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
9829402 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
CHEMBL435324 168603 None 0 Human Binding pKi = 8.7 8.7 2 2
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
10026337 112898 None 0 Rat Binding pKi = 8 8.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 441 5 1 3 5.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(Cl)cc1 10.1021/jm00019a006
CHEMBL330826 112898 None 0 Rat Binding pKi = 8 8.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 441 5 1 3 5.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(Cl)cc1 10.1021/jm00019a006
10251624 118400 None 0 Rat Binding pKi = 8 8.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 6 1 3 4.4 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1CCc1ccccc1 10.1021/jm00019a006
CHEMBL341008 118400 None 0 Rat Binding pKi = 8 8.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 6 1 3 4.4 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1CCc1ccccc1 10.1021/jm00019a006
10069913 171412 None 0 Rat Binding pKi = 8 8.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 3 3.6 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)NN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL446099 171412 None 0 Rat Binding pKi = 8 8.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 406 5 2 3 3.6 O=C1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)NN1Cc1ccccc1 10.1021/jm00019a006
44281753 99871 None 0 Human Binding pKi = 8 8.0 9 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285476 99871 None 0 Human Binding pKi = 8 8.0 9 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 626 11 1 5 7.8 CO/N=C(\COCc1cc(F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44353078 96646 None 0 Human Binding pKi = 8 8.0 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 595 7 5 5 2.6 COc1ccc(CC2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1 10.1021/jm0010217
CHEMBL263194 96646 None 0 Human Binding pKi = 8 8.0 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 595 7 5 5 2.6 COc1ccc(CC2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N2)cc1 10.1021/jm0010217
10579116 116499 None 0 Human Binding pKi = 8 8.0 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 579 7 5 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm0010217
CHEMBL336053 116499 None 0 Human Binding pKi = 8 8.0 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 579 7 5 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm0010217
10232566 4219 None 0 Human Binding pKi = 8 8.0 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100297 4219 None 0 Human Binding pKi = 8 8.0 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 607 12 2 4 6.1 CN(CCc1c[nH]c2ccccc12)C(=O)c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44577894 172518 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 616 12 3 5 4.8 CC(C)c1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL447676 172518 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 616 12 3 5 4.8 CC(C)c1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44577889 188362 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL499689 188362 None 0 Human Binding pKi = 8 8.0 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
71461644 78928 None 0 Human Binding pKi = 8 8.0 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL2112924 78928 None 0 Human Binding pKi = 8 8.0 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 784 10 10 10 -0.9 O=C(C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](Cc2ccccc2)CNC1=O)NC1OC(CO)C(O)C(O)C1O 10.1016/s0960-894x(01)00841-1
49863731 15336 None 0 Rat Binding pKi = 8 8.0 -5 3
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214024 15336 None 0 Rat Binding pKi = 8 8.0 -5 3
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
44343084 10500 None 0 Human Binding pKi = 8 8.0 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 581 7 5 4 3.4 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC2=CC=CCC2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm011127h
CHEMBL116629 10500 None 0 Human Binding pKi = 8 8.0 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 581 7 5 4 3.4 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CC2=CC=CCC2)C(=O)N[C@H](CCc2ccccc2)CN1 10.1021/jm011127h
23625471 143957 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 590 11 2 6 4.2 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1 10.1021/jm070289w
CHEMBL390174 143957 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 590 11 2 6 4.2 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1 10.1021/jm070289w
23625784 86297 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 605 11 4 5 4.2 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(Cl)c(Cl)c2)CCCC1 10.1021/jm070289w
CHEMBL231261 86297 None 0 Human Binding pKi = 8.0 8.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 605 11 4 5 4.2 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(Cl)c(Cl)c2)CCCC1 10.1021/jm070289w
10001491 118116 None 0 Rat Binding pKi = 7 7.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccncc1 10.1021/jm00019a006
CHEMBL340405 118116 None 0 Rat Binding pKi = 7 7.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccncc1 10.1021/jm00019a006
11743532 118175 None 0 Rat Binding pKi = 7 7.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 432 5 1 4 4.2 N#Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL340747 118175 None 0 Rat Binding pKi = 7 7.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 432 5 1 4 4.2 N#Cc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
10407490 168656 None 0 Rat Binding pKi = 7 7.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 381 7 3 3 3.5 OC1(CNCc2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
CHEMBL435619 168656 None 0 Rat Binding pKi = 7 7.0 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 381 7 3 3 3.5 OC1(CNCc2ccccc2)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1021/jm00019a006
44391105 65649 None 0 Human Binding pKi = 7 7.0 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183414 65649 None 0 Human Binding pKi = 7 7.0 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44281391 100034 None 0 Human Binding pKi = 7 7.0 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 688 11 1 5 9.2 CO/N=C(\CO/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286589 100034 None 0 Human Binding pKi = 7 7.0 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 688 11 1 5 9.2 CO/N=C(\CO/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44434175 89211 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 540 15 4 7 2.2 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCOCCOCCN 10.1016/j.bmcl.2007.06.053
CHEMBL236659 89211 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 540 15 4 7 2.2 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCOCCOCCN 10.1016/j.bmcl.2007.06.053
44434178 89344 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236873 89344 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434182 89468 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 12 3 5 4.5 CCN(CC)CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237081 89468 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 12 3 5 4.5 CCN(CC)CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434192 89469 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237082 89469 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434187 89639 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 10 3 6 3.5 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237516 89639 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 10 3 6 3.5 O=C(NC1(C(=O)NC(Cc2ccccc2)C(=O)NCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434197 149314 None 0 Human Binding pKi = 7 7.0 1 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394419 149314 None 0 Human Binding pKi = 7 7.0 1 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 610 11 3 6 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434179 167149 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 14 4 5 5.1 NCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL428906 167149 None 0 Human Binding pKi = 7 7.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 14 4 5 5.1 NCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44301551 101862 None 0 Rat Binding pKi = 6 6.0 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 342 8 3 3 3.2 Cc1ccccc1OCC(O)CNCCc1c[nH]c2ccc(F)cc12 10.1016/S0960-894X(01)80541-2
CHEMBL300174 101862 None 0 Rat Binding pKi = 6 6.0 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 342 8 3 3 3.2 Cc1ccccc1OCC(O)CNCCc1c[nH]c2ccc(F)cc12 10.1016/S0960-894X(01)80541-2
44391061 64878 None 0 Human Binding pKi = 6 6.0 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182104 64878 None 0 Human Binding pKi = 6 6.0 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
23625323 92415 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 522 11 2 6 2.5 CN(CC(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(=O)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243069 92415 None 0 Human Binding pKi = 6 6.0 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 522 11 2 6 2.5 CN(CC(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(=O)c1cc2ccccc2s1 10.1021/jm070289w
44391019 63901 None 0 Human Binding pKi = 5 5.0 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180396 63901 None 0 Human Binding pKi = 5 5.0 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1cccc(-c2ccccc2)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
51351496 60628 None 5 Human Binding pKi = 5 5.0 -18 4
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760205 60628 None 5 Human Binding pKi = 5 5.0 -18 4
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)nn2C)CC1 10.1016/j.bmcl.2011.02.033
90417914 118929 None 0 Human Binding pKi = 5 5.0 -3235 5
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
CHEMBL3422015 118929 None 0 Human Binding pKi = 5 5.0 -3235 5
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 433 4 0 7 5.0 CC(C)c1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)co1 10.1021/jm5017413
44434159 145885 None 0 Human Binding pKi = 5 5.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL391696 145885 None 0 Human Binding pKi = 5 5.0 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
44392497 65030 None 0 Human Binding pKi = 5 5.0 - 1
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 535 7 0 3 6.1 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
CHEMBL182317 65030 None 0 Human Binding pKi = 5 5.0 - 1
Ki for human Neurokinin 2 receptorKi for human Neurokinin 2 receptor
ChEMBL 535 7 0 3 6.1 O=C1CC[C@](CCN2CC(N3CCC(F)CC3)C2)(c2ccc(Cl)c(Cl)c2)CN1C1(C2CC2)CCCC1 10.1016/j.bmcl.2005.05.134
57391133 68389 None 0 Human Binding pKi = 4 4.0 -1 2
Displacement of [125I]NKA from human NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
CHEMBL1916635 68389 None 0 Human Binding pKi = 4 4.0 -1 2
Displacement of [125I]NKA from human NK2 receptor expressed in CHO cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHO cells
ChEMBL 691 12 3 7 4.4 COC(=O)C1=C2CCC(C(=O)N[C@@H](CCc3c[nH]c4ccccc34)C(=O)N(C)Cc3ccccc3)N2C(=O)C(NC(=O)OCc2ccccc2)C1 10.1016/j.ejmech.2011.08.042
2098 3694 None 31 Human Binding pKi = 7.0 7.0 -457 6
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
36511 3694 None 31 Human Binding pKi = 7.0 7.0 -457 6
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3805 3694 None 31 Human Binding pKi = 7.0 7.0 -457 6
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
3835 3694 None 31 Human Binding pKi = 7.0 7.0 -457 6
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL235363 3694 None 31 Human Binding pKi = 7.0 7.0 -457 6
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
10232846 114180 None 0 Human Binding pKi = 7.0 7.0 -11 2
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL332793 114180 None 0 Human Binding pKi = 7.0 7.0 -11 2
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL411905 215422 None 0 Human Binding pKi = 6.0 6.0 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL None None None CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](C)/N=C(/S)Nc1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)C(N)=O 10.1021/jm00039a012
44380763 120097 None 0 Human Binding pKi = 7.0 7.0 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL350360 120097 None 0 Human Binding pKi = 7.0 7.0 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 690 12 1 5 9.1 CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
5353853 17993 None 30 Human Binding pKi = 6.0 6.0 -14 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
9556529 17993 None 30 Human Binding pKi = 6.0 6.0 -14 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1262 17993 None 30 Human Binding pKi = 6.0 6.0 -14 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 427 6 0 4 6.1 Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
25221995 199307 None 0 Human Binding pKi = 7.0 7.0 -40 4
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
CHEMBL565894 199307 None 0 Human Binding pKi = 7.0 7.0 -40 4
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 601 8 0 3 6.5 CN(Cc1ccc(F)c(C(F)(F)F)c1)C(=O)C(C)(CCN1CCC(N2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm900948q
10010096 99944 None 0 Human Binding pKi = 8.0 8.0 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285986 99944 None 0 Human Binding pKi = 8.0 8.0 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 719 10 1 6 8.6 CO/N=C(\CN(C)C(=O)Oc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215303 119026 None 0 Human Binding pKi = 8.0 8.0 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342341 119026 None 0 Human Binding pKi = 8.0 8.0 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 710 12 1 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363952 121075 None 0 Human Binding pKi = 8.0 8.0 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356508 121075 None 0 Human Binding pKi = 8.0 8.0 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 696 12 1 6 7.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380069 57634 None 0 Human Binding pKi = 7.9 7.9 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166842 57634 None 0 Human Binding pKi = 7.9 7.9 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 714 14 0 6 8.1 CSCCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44266459 4523 None 0 Human Binding pKi = 7.0 7.0 -91 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 381 5 2 3 5.4 CC[C@@H](NC(=O)c1c(N)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10224 4523 None 0 Human Binding pKi = 7.0 7.0 -91 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 381 5 2 3 5.4 CC[C@@H](NC(=O)c1c(N)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44281392 100012 None 0 Human Binding pKi = 6.9 6.9 -3 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286433 100012 None 0 Human Binding pKi = 6.9 6.9 -3 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 12 1 5 8.8 CO/N=C(\COCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281722 111454 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 590 11 1 5 7.8 CO/N=C(\COCc1ccc2ccccc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32717 111454 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 590 11 1 5 7.8 CO/N=C(\COCc1ccc2ccccc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215305 119318 None 0 Human Binding pKi = 7.9 7.9 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343627 119318 None 0 Human Binding pKi = 7.9 7.9 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 695 12 0 5 8.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10002284 16888 None 0 Rat Binding pKi = 7.9 7.9 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccccc1CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL125001 16888 None 0 Rat Binding pKi = 7.9 7.9 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.6 Cc1ccccc1CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
44434168 88787 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 580 15 4 7 3.2 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236250 88787 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 580 15 4 7 3.2 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
90663622 106765 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.3 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL3143848 106765 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.3 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44577891 188783 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL503837 188783 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
23625633 92632 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 599 11 4 5 3.4 O=C(Nc1ccc(Br)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243502 92632 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 599 11 4 5 3.4 O=C(Nc1ccc(Br)cc1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
44342868 10564 None 0 Human Binding pKi = 7.9 7.9 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 680 10 7 6 1.5 O=C(O)CCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL116969 10564 None 0 Human Binding pKi = 7.9 7.9 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 680 10 7 6 1.5 O=C(O)CCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
44342903 110364 None 0 Human Binding pKi = 7.9 7.9 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 597 7 5 5 3.0 COc1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC3=CC=CCC3)C(=O)N2)cc1 10.1021/jm011127h
CHEMBL323836 110364 None 0 Human Binding pKi = 7.9 7.9 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 597 7 5 5 3.0 COc1ccc(C[C@@H]2CNC(=O)CCC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](CC3=CC=CCC3)C(=O)N2)cc1 10.1021/jm011127h
CHEMBL431641 216087 None 0 Human Binding pKi = 7.9 7.9 - 1
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44390541 64060 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL180725 64060 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44391089 64297 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180942 64297 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 516 12 3 5 3.8 O=C(Nc1ccc(OCc2ccccc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL5092328 217849 None 7 Human Binding pKi = 5.9 5.9 6 4
Displacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysisDisplacement of [125I]NKA from human recombinant NK2 receptor after 60 mins by scintillation counting analysis
ChEMBL None None None CCS(=O)(=O)[C@]1(C)CC[C@@](CF)(c2cc(NC(=O)c3cc4c(cn3)OC(F)(F)O4)ccc2F)N=C1N 10.1021/acs.jmedchem.1c00935
8867347 60623 None 2 Human Binding pKi = 4.9 4.9 -10 4
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760200 60623 None 2 Human Binding pKi = 4.9 4.9 -10 4
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 362 4 1 4 3.0 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccccc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
44305793 100899 None 0 Human Binding pKi = 6.9 6.9 -5 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL293432 100899 None 0 Human Binding pKi = 6.9 6.9 -5 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
6604014 210307 None 4 Human Binding pKi = 5.9 5.9 -28 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL9643 210307 None 4 Human Binding pKi = 5.9 5.9 -28 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
5764 3497 None 36 Human Binding pKi = 5.9 5.9 -58 2
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
6604858 3497 None 36 Human Binding pKi = 5.9 5.9 -58 2
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
CHEMBL9843 3497 None 36 Human Binding pKi = 5.9 5.9 -58 2
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)[C@@H](c1ccccc1)NC(=O)c1cc(nc2c1cccc2)c1ccccc1 10.1021/jm960818o
1016 3747 None 45 Human Binding pKi = 5.9 5.9 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2561 3747 None 45 Human Binding pKi = 5.9 5.9 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
2733526 3747 None 45 Human Binding pKi = 5.9 5.9 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
5384 3747 None 45 Human Binding pKi = 5.9 5.9 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
CHEMBL83 3747 None 45 Human Binding pKi = 5.9 5.9 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
DB00675 3747 None 45 Human Binding pKi = 5.9 5.9 -16 35
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 nan
23625473 166871 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 540 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cccc(Cl)c1 10.1021/jm070289w
CHEMBL428394 166871 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 540 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cccc(Cl)c1 10.1021/jm070289w
19610193 107288 None 0 Human Binding pKi = 6.9 6.9 -1 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
CHEMBL316740 107288 None 0 Human Binding pKi = 6.9 6.9 -1 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 654 10 1 7 5.3 COc1cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)cc(OC)c1OC 10.1016/s0960-894x(02)00645-5
10454808 168653 None 0 Rat Binding pKi = 6.9 6.9 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 420 5 2 3 3.4 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)C(=O)N1Cc1ccccc1 10.1021/jm00019a006
CHEMBL435610 168653 None 0 Rat Binding pKi = 6.9 6.9 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 420 5 2 3 3.4 O=C1NC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)C(=O)N1Cc1ccccc1 10.1021/jm00019a006
44331223 210850 None 0 Human Binding pKi = 6.9 6.9 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 706 16 2 8 4.3 O=C(c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL99608 210850 None 0 Human Binding pKi = 6.9 6.9 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 706 16 2 8 4.3 O=C(c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434169 89077 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 568 10 4 5 4.8 NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)cc1 10.1016/j.bmcl.2007.06.053
CHEMBL236458 89077 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 568 10 4 5 4.8 NCc1ccc(CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)cc1 10.1016/j.bmcl.2007.06.053
44434181 89347 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 15 4 5 5.5 NCCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236874 89347 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 15 4 5 5.5 NCCCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
10995343 20853 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccccc2)CN1 10.1021/jm0010217
CHEMBL131024 20853 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccccc2)CN1 10.1021/jm0010217
10554969 78531 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC[C@H](Cc2ccccc2)N1 10.1021/jm0010217
CHEMBL2111858 78531 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC[C@H](Cc2ccccc2)N1 10.1021/jm0010217
11801084 78814 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@H](Cc2ccccc2)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
CHEMBL2112669 78814 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 565 6 5 4 2.6 O=C1CCC(=O)N[C@H](Cc2ccccc2)CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm0010217
10576528 110548 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
CHEMBL324804 110548 None 0 Human Binding pKi = 5.9 5.9 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm0010217
10576528 110548 None 0 Human Binding pKi = 5.9 5.9 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
CHEMBL324804 110548 None 0 Human Binding pKi = 5.9 5.9 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 475 4 5 4 0.9 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCN1 10.1021/jm011127h
71533722 118924 None 0 Human Binding pKi = 4.9 4.9 -933 5
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
CHEMBL3422010 118924 None 0 Human Binding pKi = 4.9 4.9 -933 5
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 10.1021/jm5017413
71549769 118932 None 0 Human Binding pKi = 4.9 4.9 -3981 5
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
CHEMBL3422018 118932 None 0 Human Binding pKi = 4.9 4.9 -3981 5
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 422 3 0 8 4.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 10.1021/jm5017413
44312761 103632 None 0 Human Binding pKi = 4.9 4.9 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 576 12 0 8 6.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL308613 103632 None 0 Human Binding pKi = 4.9 4.9 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 576 12 0 8 6.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
44312564 207020 None 0 Human Binding pKi = 4.9 4.9 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL72979 207020 None 0 Human Binding pKi = 4.9 4.9 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(O)C2S1 10.1016/s0960-894x(02)00471-7
1836 2592 None 44 Human Binding pKi = 5.9 5.9 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
3340 2592 None 44 Human Binding pKi = 5.9 5.9 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
5281040 2592 None 44 Human Binding pKi = 5.9 5.9 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
5281040.0 2592 None 44 Human Binding pKi = 5.9 5.9 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
CHEMBL787 2592 None 44 Human Binding pKi = 5.9 5.9 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
DB00471 2592 None 44 Human Binding pKi = 5.9 5.9 -40 15
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 585 12 2 4 8.9 OC(=O)CC1(CS[C@@H](c2cccc(c2)/C=C/c2ccc3c(n2)cc(cc3)Cl)CCc2ccccc2C(O)(C)C)CC1 nan
44314834 207607 None 0 Human Binding pKi = 6.9 6.9 -2 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78092 207607 None 0 Human Binding pKi = 6.9 6.9 -2 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 667 11 0 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44281359 110632 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 546 11 1 5 7.1 CO/N=C(\COCC1CCCCC1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32533 110632 None 0 Human Binding pKi = 7.9 7.9 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 546 11 1 5 7.1 CO/N=C(\COCC1CCCCC1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9987474 207291 None 0 Human Binding pKi = 7.9 7.9 1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75436 207291 None 0 Human Binding pKi = 7.9 7.9 1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
22405758 199522 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 9 1 3 5.7 CCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56739 199522 None 0 Human Binding pKi = 7.9 7.9 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 476 9 1 3 5.7 CCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44390601 64296 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 536 11 3 5 4.5 O=C(Nc1ccc(Sc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180940 64296 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 536 11 3 5 4.5 O=C(Nc1ccc(Sc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44281785 111426 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 652 11 1 5 9.3 CO/N=C(\COCc1cc(C(C)(C)C)cc(C(C)(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32700 111426 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 652 11 1 5 9.3 CO/N=C(\COCc1cc(C(C)(C)C)cc(C(C)(C)C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44282004 121826 None 0 Human Binding pKi = 6.9 6.9 -2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL35891 121826 None 0 Human Binding pKi = 6.9 6.9 -2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 675 11 2 5 8.3 CO/N=C(\CNCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
51351504 60629 None 1 Human Binding pKi = 4.9 4.9 -34 4
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760206 60629 None 1 Human Binding pKi = 4.9 4.9 -34 4
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 410 4 0 5 3.7 COc1ccccc1N1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n(C)n2)CC1 10.1016/j.bmcl.2011.02.033
2351 3286 None 44 Human Binding pKi = 5.9 5.9 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
2820 3286 None 44 Human Binding pKi = 5.9 5.9 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
5035 3286 None 44 Human Binding pKi = 5.9 5.9 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
CHEMBL81 3286 None 44 Human Binding pKi = 5.9 5.9 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
DB00481 3286 None 44 Human Binding pKi = 5.9 5.9 -13 21
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 473 7 2 6 6.1 Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O nan
132837 2237 None 40 Rat Binding pKi = 6.9 6.9 -18 5
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
9461 2237 None 40 Rat Binding pKi = 6.9 6.9 -18 5
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
CHEMBL22870 2237 None 40 Rat Binding pKi = 6.9 6.9 -18 5
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 472 6 2 3 5.0 CC(=O)N[C@H](C(=O)OCc1cc(cc(c1)C(F)(F)F)C(F)(F)F)Cc1c[nH]c2c1cccc2 10.1021/jm100157m
133 2496 None 39 Human Binding pKi = 5.9 5.9 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
1723 2496 None 39 Human Binding pKi = 5.9 5.9 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
28693 2496 None 39 Human Binding pKi = 5.9 5.9 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
CHEMBL19215 2496 None 39 Human Binding pKi = 5.9 5.9 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
DB13520 2496 None 39 Human Binding pKi = 5.9 5.9 -165 42
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 403 4 1 4 4.1 O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C nan
44281397 163063 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccccc1C)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL417490 163063 None 0 Human Binding pKi = 6.9 6.9 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1ccccc1C)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44364001 39917 None 0 Human Binding pKi = 6.9 6.9 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147767 39917 None 0 Human Binding pKi = 6.9 6.9 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 717 13 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
3598 187927 None 45 Human Binding pKi = 5.9 5.9 -1 7
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
CHEMBL496 187927 None 45 Human Binding pKi = 5.9 5.9 -1 7
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
1024 1289 None 44 Human Binding pKi = 5.9 5.9 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
162639143 1289 None 44 Human Binding pKi = 5.9 5.9 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
5284373 1289 None 44 Human Binding pKi = 5.9 5.9 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
760 1289 None 44 Human Binding pKi = 5.9 5.9 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
CHEMBL160 1289 None 44 Human Binding pKi = 5.9 5.9 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
DB00091 1289 None 44 Human Binding pKi = 5.9 5.9 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
44380732 59009 None 0 Human Binding pKi = 7.9 7.9 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL169002 59009 None 0 Human Binding pKi = 7.9 7.9 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 2 6 8.1 OCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44337371 5293 None 0 Human Binding pKi = 7.9 7.9 -4 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106572 5293 None 0 Human Binding pKi = 7.9 7.9 -4 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 720 7 1 4 6.8 O=C(c1cc(Br)cc(Br)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337288 8047 None 0 Human Binding pKi = 7.9 7.9 -1 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL109092 8047 None 0 Human Binding pKi = 7.9 7.9 -1 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 632 7 1 4 6.6 O=C(c1cc(Cl)cc(Cl)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44281345 110543 None 0 Human Binding pKi = 7.9 7.9 10 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32477 110543 None 0 Human Binding pKi = 7.9 7.9 10 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 554 11 1 5 7.0 CO/N=C(\COCc1cccc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44215306 37185 None 0 Human Binding pKi = 7.9 7.9 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145302 37185 None 0 Human Binding pKi = 7.9 7.9 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 725 14 1 6 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CCO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
23625475 92615 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 632 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(I)cc1 10.1021/jm070289w
CHEMBL243280 92615 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 632 11 3 5 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc(I)cc1 10.1021/jm070289w
155565189 175669 None 0 Human Binding pKi = 6.9 6.9 2 4
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
CHEMBL4579120 175669 None 0 Human Binding pKi = 6.9 6.9 2 4
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 634 7 0 9 6.2 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CCCCCCOCc3cn(nn3)C[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12 10.1016/j.ejmech.2019.04.064
71533722 118924 None 0 Human Binding pKi = 4.9 4.9 -933 5
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
CHEMBL3422010 118924 None 0 Human Binding pKi = 4.9 4.9 -933 5
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 421 3 0 7 4.7 Cc1nc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)cs1 nan
44300668 200281 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 448 8 1 3 4.9 CN(CC(CCN1CCC(CO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL57224 200281 None 0 Human Binding pKi = 6.9 6.9 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 448 8 1 3 4.9 CN(CC(CCN1CCC(CO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL102128 210913 None 0 Human Binding pKi = 5.9 5.9 - 1
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
2132 3744 None 43 Human Binding pKi = 6.8 6.8 -97 6
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
5311424 3744 None 43 Human Binding pKi = 6.8 6.8 -97 6
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
CHEMBL10188 3744 None 43 Human Binding pKi = 6.8 6.8 -97 6
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
44363756 39850 None 0 Human Binding pKi = 6.8 6.8 -8 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147715 39850 None 0 Human Binding pKi = 6.8 6.8 -8 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 703 12 1 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10691318 167713 None 2 Human Binding pKi = 6.8 6.8 -102 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 382 5 2 3 5.5 CC[C@@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL430118 167713 None 2 Human Binding pKi = 6.8 6.8 -102 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 382 5 2 3 5.5 CC[C@@H](NC(=O)c1c(O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
2132 3744 None 43 Human Binding pKi = 6.8 6.8 -97 6
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
5311424 3744 None 43 Human Binding pKi = 6.8 6.8 -97 6
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
CHEMBL10188 3744 None 43 Human Binding pKi = 6.8 6.8 -97 6
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm000501v
44363877 39161 None 0 Human Binding pKi = 6.8 6.8 -3 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146947 39161 None 0 Human Binding pKi = 6.8 6.8 -3 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 709 12 1 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(NC(=O)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44281538 110369 None 0 Human Binding pKi = 7.8 7.8 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32385 110369 None 0 Human Binding pKi = 7.8 7.8 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 696 11 1 5 8.2 CO/N=C(\COCc1cc(Br)cc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363442 37951 None 0 Human Binding pKi = 7.8 7.8 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL145959 37951 None 0 Human Binding pKi = 7.8 7.8 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44329517 210736 None 0 Golden hamster Binding pKi = 7.8 7.8 36 2
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
CHEMBL98929 210736 None 0 Golden hamster Binding pKi = 7.8 7.8 36 2
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
10001490 162037 None 0 Rat Binding pKi = 7.8 7.8 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccn1 10.1021/jm00019a006
CHEMBL415518 162037 None 0 Rat Binding pKi = 7.8 7.8 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccn1 10.1021/jm00019a006
44577910 188317 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 606 12 3 6 4.2 O=C(/C=C/c1cccs1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL499153 188317 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 606 12 3 6 4.2 O=C(/C=C/c1cccs1)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
2090 2767 None 27 Human Binding pKi = 7.8 7.8 -38 4
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
5311312 2767 None 27 Human Binding pKi = 7.8 7.8 -38 4
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
CHEMBL437797 2767 None 27 Human Binding pKi = 7.8 7.8 -38 4
Displacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysisDisplacement of [125I]NKA from human NK2R expressed in CHO cell membranes after 90 mins by scintillation counting analysis
ChEMBL None None None None 10.1021/jm5017413
11421866 137301 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
CHEMBL375053 137301 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
46236800 6785 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
CHEMBL1083862 6785 None 0 Human Binding pKi = 7.8 7.8 - 1
Displacement of [3H]neurokinin A from human NK2 receptorDisplacement of [3H]neurokinin A from human NK2 receptor
ChEMBL 616 11 2 6 5.4 Cc1ccc2cc(C(=O)NC3(C(=O)N[C@@H](CCN4CCN(CC5CCOCC5)CC4)Cc4ccccc4)CCCC3)sc2c1 10.1021/jm100176s
1752 45775 None 35 Human Binding pKi = 5.8 5.8 -1 5
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
CHEMBL153062 45775 None 35 Human Binding pKi = 5.8 5.8 -1 5
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 220 8 1 1 4.7 CCCCCCCCCc1ccc(O)cc1 nan
1548953 210138 None 21 Human Binding pKi = 5.8 5.8 -7 17
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL954 210138 None 21 Human Binding pKi = 5.8 5.8 -7 17
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 405 9 0 2 6.6 CCN(CC)CCOc1ccc(/C(=C(/Cl)c2ccccc2)c2ccccc2)cc1 nan
CHEMBL1201469 14513 None 0 Human Binding pKi = 5.8 5.8 1 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL None None None None nan
2406 100458 None 56 Human Binding pKi = 5.8 5.8 -16 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL290106 100458 None 56 Human Binding pKi = 5.8 5.8 -16 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 354 2 2 3 5.9 Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O nan
CHEMBL103939 210919 None 0 Human Binding pKi = 6.8 6.8 - 1
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(N)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
44281743 99693 None 0 Human Binding pKi = 6.8 6.8 -2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284244 99693 None 0 Human Binding pKi = 6.8 6.8 -2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 11 1 5 9.1 CO/N=C(\C(C)OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10471895 118141 None 0 Rat Binding pKi = 5.8 5.8 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 331 3 1 3 2.8 CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL340548 118141 None 0 Rat Binding pKi = 5.8 5.8 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 331 3 1 3 2.8 CN1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
44301858 202543 None 0 Rat Binding pKi = 5.8 5.8 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 372 5 2 3 3.5 N#Cc1ccc2[nH]cc(CCN3CCC(NC(=O)c4ccccc4)CC3)c2c1 10.1016/S0960-894X(01)80541-2
CHEMBL59594 202543 None 0 Rat Binding pKi = 5.8 5.8 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 372 5 2 3 3.5 N#Cc1ccc2[nH]cc(CCN3CCC(NC(=O)c4ccccc4)CC3)c2c1 10.1016/S0960-894X(01)80541-2
CHEMBL583102 218271 None 7 Human Binding pKi = 5.8 5.8 -5248 2
Binding affinity at human NK2 receptorBinding affinity at human NK2 receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O 10.1021/jm2017072
CHEMBL583102 218271 None 7 Human Binding pKi = 5.8 5.8 -5248 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(=O)O)C(N)=O 10.1021/jm900948q
11203189 64309 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181004 64309 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2ccc(F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44337353 5429 None 0 Human Binding pKi = 7.8 7.8 9 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL107306 5429 None 0 Human Binding pKi = 7.8 7.8 9 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 635 7 2 5 4.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)c4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44363983 18173 None 0 Human Binding pKi = 7.8 7.8 -2 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL126970 18173 None 0 Human Binding pKi = 7.8 7.8 -2 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 769 15 2 7 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC(O)CO)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363926 39080 None 0 Human Binding pKi = 7.8 7.8 -3 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL146882 39080 None 0 Human Binding pKi = 7.8 7.8 -3 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 669 11 1 6 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10010039 39918 None 0 Human Binding pKi = 7.8 7.8 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL147769 39918 None 0 Human Binding pKi = 7.8 7.8 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 14 2 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CNC2(CO)CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380457 58133 None 0 Human Binding pKi = 7.8 7.8 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167613 58133 None 0 Human Binding pKi = 7.8 7.8 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 0 7 6.6 COC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
49863733 15338 None 0 Rat Binding pKi = 6.8 6.8 -2 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214026 15338 None 0 Rat Binding pKi = 6.8 6.8 -2 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44391130 64956 None 0 Human Binding pKi = 5.8 5.8 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
CHEMBL182264 64956 None 0 Human Binding pKi = 5.8 5.8 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
44391136 66125 None 0 Human Binding pKi = 5.8 5.8 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183917 66125 None 0 Human Binding pKi = 5.8 5.8 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
73354570 89444 None 0 Human Binding pKi = 5.8 5.8 -13 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
CHEMBL2370513 89444 None 0 Human Binding pKi = 5.8 5.8 -13 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 814 8 8 9 0.4 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1CC=C(C)C 10.1021/jm00029a007
155558726 174912 None 0 Human Binding pKi = 5.8 5.8 -3 4
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
CHEMBL4562303 174912 None 0 Human Binding pKi = 5.8 5.8 -3 4
Displacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter methodDisplacement of [125I]NKA from human recombinant NK2 receptor measured after 60 mins by scintillation counter method
ChEMBL 835 11 0 13 6.7 CC(C)CCO[C@H]1[C@H]2CCN(CCc3ccc4ccccc4c3)CC[C@H]3O[C@H](Cn4cc(nn4)COC[C@@H](O2)[C@@H]2OC(C)(C)O[C@H]12)[C@@H]1OC(C)(C)O[C@@H]1[C@H]3OCCC(C)C 10.1016/j.ejmech.2019.04.064
4189 209380 None 58 Human Binding pKi = 5.8 5.8 -18 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL1559 209380 None 58 Human Binding pKi = 5.8 5.8 -18 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
CHEMBL91 209380 None 58 Human Binding pKi = 5.8 5.8 -18 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 414 6 0 3 6.5 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1 nan
5318 15583 None 40 Human Binding pKi = 5.8 5.8 -1 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1200348 15583 None 40 Human Binding pKi = 5.8 5.8 -1 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1221 15583 None 40 Human Binding pKi = 5.8 5.8 -1 13
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 396 6 0 3 6.5 Clc1ccc(CSC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44281957 99870 None 0 Human Binding pKi = 6.8 6.8 -27 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285475 99870 None 0 Human Binding pKi = 6.8 6.8 -27 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 703 10 1 5 8.1 CO/N=C(\C(=O)N(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44380290 100144 None 0 Human Binding pKi = 7.8 7.8 -21 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL287369 100144 None 0 Human Binding pKi = 7.8 7.8 -21 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 736 14 0 9 6.5 CN(C/C(=N\OCCCn1cnnn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
15887537 109102 None 0 Human Binding pKi = 7.8 7.8 -3 3
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL321270 109102 None 0 Human Binding pKi = 7.8 7.8 -3 3
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44281303 100524 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 582 11 1 8 6.2 CO/N=C(\COCc1ccc2nonc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL290786 100524 None 0 Human Binding pKi = 7.8 7.8 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 582 11 1 8 6.2 CO/N=C(\COCc1ccc2nonc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314946 207521 None 0 Human Binding pKi = 6.8 6.8 -2 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77235 207521 None 0 Human Binding pKi = 6.8 6.8 -2 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 0 6 8.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C(C)C)C(C)C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
5362440 10023 None 41 Human Binding pKi = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
CHEMBL115 10023 None 41 Human Binding pKi = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
CHEMBL5483011 10023 None 41 Human Binding pKi = 5.8 5.8 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 613 11 4 7 2.9 CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O nan
44266422 4443 None 0 Human Binding pKi = 6.8 6.8 -79 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 423 7 1 3 5.8 CC[C@@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10162 4443 None 0 Human Binding pKi = 6.8 6.8 -79 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 423 7 1 3 5.8 CC[C@@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
10812218 172175 None 0 Human Binding pKi = 6.8 6.8 -79 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 423 7 1 3 5.8 CC[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL44722 172175 None 0 Human Binding pKi = 6.8 6.8 -79 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 423 7 1 3 5.8 CC[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44337414 9217 None 0 Human Binding pKi = 6.8 6.8 -5 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110507 9217 None 0 Human Binding pKi = 6.8 6.8 -5 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 889 13 2 7 9.1 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00645-5
44329163 111512 None 0 Human Binding pKi = 4.8 4.8 -2 2
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL327531 111512 None 0 Human Binding pKi = 4.8 4.8 -2 2
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 344 3 2 6 2.8 Cc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
22901328 210127 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 420 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(O)CC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL95347 210127 None 0 Human Binding pKi = 5.8 5.8 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 420 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(O)CC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44281713 99717 None 0 Human Binding pKi = 7.8 7.8 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284396 99717 None 0 Human Binding pKi = 7.8 7.8 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 600 13 1 7 6.7 CO/N=C(\COCc1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9849950 101425 None 0 Human Binding pKi = 7.7 7.7 64 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 8 1 4 5.3 CCC(CC)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
CHEMBL297086 101425 None 0 Human Binding pKi = 7.7 7.7 64 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 458 8 1 4 5.3 CCC(CC)NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12 10.1021/jm000501v
10189341 10121 None 0 Human Binding pKi = 6.7 6.7 -10 2
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL115633 10121 None 0 Human Binding pKi = 6.7 6.7 -10 2
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
141952732 120529 None 0 Human Binding pKi = 7.7 7.7 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380527 120529 None 0 Human Binding pKi = 7.7 7.7 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
CHEMBL354091 120529 None 0 Human Binding pKi = 7.7 7.7 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 3 7 7.8 N/C(CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)=N/O 10.1016/s0960-894x(02)00027-6
44380095 120920 None 0 Human Binding pKi = 7.7 7.7 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355868 120920 None 0 Human Binding pKi = 7.7 7.7 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 687 11 1 6 8.6 N#CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10390570 16551 None 0 Rat Binding pKi = 7.7 7.7 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 483 6 1 3 5.9 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(c1ccccc1)c1ccccc1 10.1021/jm00019a006
CHEMBL123731 16551 None 0 Rat Binding pKi = 7.7 7.7 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 483 6 1 3 5.9 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(c1ccccc1)c1ccccc1 10.1021/jm00019a006
10093650 16810 None 0 Rat Binding pKi = 7.7 7.7 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.9 CC(c1ccccc1)N1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
CHEMBL124624 16810 None 0 Rat Binding pKi = 7.7 7.7 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 5 1 3 4.9 CC(c1ccccc1)N1CC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)OC1=O 10.1021/jm00019a006
10344101 116905 None 0 Rat Binding pKi = 7.7 7.7 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc2ccccc2c1 10.1021/jm00019a006
CHEMBL338030 116905 None 0 Rat Binding pKi = 7.7 7.7 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 457 5 1 3 5.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc2ccccc2c1 10.1021/jm00019a006
11802167 78819 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)CN1 10.1021/jm0010217
CHEMBL2112675 78819 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 633 6 5 4 3.6 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)CN1 10.1021/jm0010217
44434171 89360 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.0 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL236890 89360 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 614 15 4 7 3.0 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)Cc2ccccc2C1 10.1016/j.bmcl.2007.06.053
44434184 89546 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237303 89546 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577885 188726 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL502914 188726 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
54583959 60689 None 0 Human Binding pKi = 4.7 4.7 -38 4
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
CHEMBL1760339 60689 None 0 Human Binding pKi = 4.7 4.7 -38 4
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 410 5 1 4 3.7 COc1ccccc1CN1CCN(C(=O)c2cc(-c3ccc(Cl)cc3)n[nH]2)CC1 10.1016/j.bmcl.2011.02.033
11790 99541 None 62 Human Binding pKi = 5.7 5.7 -2 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
CHEMBL283196 99541 None 62 Human Binding pKi = 5.7 5.7 -2 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 272 1 0 2 4.6 O=c1cc(-c2ccccc2)oc2c1ccc1ccccc12 nan
118724123 116476 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 954 29 11 16 -1.6 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O 10.1021/jm401823z
CHEMBL3360202 116476 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 954 29 11 16 -1.6 CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)C(CCNc1ccc([N+](=O)[O-])c2nonc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(C)=O)C(N)=O 10.1021/jm401823z
44363948 36387 None 0 Human Binding pKi = 6.7 6.7 -5 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144668 36387 None 0 Human Binding pKi = 6.7 6.7 -5 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 653 11 0 5 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380795 208590 None 0 Human Binding pKi = 6.7 6.7 -7 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL85980 208590 None 0 Human Binding pKi = 6.7 6.7 -7 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 13 1 7 8.3 COC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10454135 17979 None 0 Rat Binding pKi = 6.7 6.7 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccnc1 10.1021/jm00019a006
CHEMBL126158 17979 None 0 Rat Binding pKi = 6.7 6.7 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 408 5 1 4 3.7 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1cccnc1 10.1021/jm00019a006
44380415 120379 None 0 Human Binding pKi = 8.7 8.7 -2 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352813 120379 None 0 Human Binding pKi = 8.7 8.7 -2 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 683 12 1 6 5.9 CN(C/C(=N\OCC(N)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44281685 100085 None 0 Human Binding pKi = 8.7 8.7 5 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286901 100085 None 0 Human Binding pKi = 8.7 8.7 5 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 587 10 1 6 6.6 CO/N=C(\CN(C)C(=O)c1ccc(C)s1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281977 109450 None 0 Human Binding pKi = 8.7 8.7 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32197 109450 None 0 Human Binding pKi = 8.7 8.7 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 595 10 1 5 6.8 CO/N=C(\CN(C)C(=O)c1cc(C)cc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281976 110637 None 0 Human Binding pKi = 8.7 8.7 2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32537 110637 None 0 Human Binding pKi = 8.7 8.7 2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 627 12 1 7 6.2 CO/N=C(\CN(C)C(=O)c1cc(OC)cc(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10394882 113876 None 0 Human Binding pKi = 8.7 8.7 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33249 113876 None 0 Human Binding pKi = 8.7 8.7 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 10 2 5 7.9 CO/N=C(\CNC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
137633652 156687 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
CHEMBL4068783 156687 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [125I]NKA from human recombinant tachykinin NK2 receptor expressed in CHO cells after 60 mins by scintillation counting
ChEMBL 749 24 10 10 -1.5 CCCCC(NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)O 10.1021/acs.jmedchem.6b01422
9918520 102806 None 0 Guinea pig Binding pKi = 8.7 8.7 -2 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL305055 102806 None 0 Guinea pig Binding pKi = 8.7 8.7 -2 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 753 12 1 7 5.8 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)N3CC(O)C3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9896563 103835 None 0 Guinea pig Binding pKi = 8.7 8.7 -5 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
CHEMBL308891 103835 None 0 Guinea pig Binding pKi = 8.7 8.7 -5 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 711 12 1 6 6.4 CNC(=O)CC1CCCN(C2CCN(CCC(/C(CN(C)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(02)00340-2
44307953 169297 None 0 Guinea pig Binding pKi = 8.7 8.7 -35 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL440679 169297 None 0 Guinea pig Binding pKi = 8.7 8.7 -35 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL540651 169297 None 0 Guinea pig Binding pKi = 8.7 8.7 -35 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 784 12 1 7 6.4 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(=O)[S+]3CCNCC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
9939307 205944 None 0 Guinea pig Binding pKi = 8.7 8.7 -6 4
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL66106 205944 None 0 Guinea pig Binding pKi = 8.7 8.7 -6 4
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 640 10 0 5 7.0 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
52918297 58506 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 611 12 2 6 4.8 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2cn1 10.1016/j.bmcl.2011.01.074
CHEMBL1683152 58506 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 611 12 2 6 4.8 O=C(NC1(C(=O)N[C@H](CCCN2CCN(CC3CCOCC3)CC2)Cc2ccccc2)CCCC1)c1cc2ccccc2cn1 10.1016/j.bmcl.2011.01.074
23626111 86180 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 645 12 3 7 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL231173 86180 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 645 12 3 7 4.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
22405735 78451 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N/O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2111522 78451 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CC/C(=N/O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23625785 152759 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 556 11 3 5 3.4 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ccccc2c1 10.1021/jm070289w
CHEMBL397264 152759 None 0 Human Binding pKi = 8.7 8.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 556 11 3 5 3.4 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ccccc2c1 10.1021/jm070289w
10187380 152758 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 545 11 4 5 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2[nH]1 10.1021/jm070289w
CHEMBL397263 152758 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 545 11 4 5 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2[nH]1 10.1021/jm070289w
10209751 86039 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 559 11 3 6 2.8 Cn1c(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc2ccccc21 10.1021/jm070289w
CHEMBL230426 86039 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 559 11 3 6 2.8 Cn1c(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc2ccccc21 10.1021/jm070289w
23653789 3587 None 25 Human Binding pKi = 8.6 8.6 1 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9280 3587 None 25 Human Binding pKi = 8.6 8.6 1 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
CHEMBL447955 3587 None 25 Human Binding pKi = 8.6 8.6 1 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
DB12973 3587 None 25 Human Binding pKi = 8.6 8.6 1 2
Binding affinity to human NK2 receptorBinding affinity to human NK2 receptor
ChEMBL 555 5 0 3 7.7 O=C1CCC(=C1)N1C[C@@H]2[C@@H](C1)[C@@H]([C@H](CC2)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C)c1ccc(cc1)F 10.1021/jm8016514
9825316 179614 None 0 Human Binding pKi = 8.6 8.6 1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 456 6 2 4 5.0 C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47412 179614 None 0 Human Binding pKi = 8.6 8.6 1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 456 6 2 4 5.0 C[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
44315267 105561 None 0 Human Binding pKi = 8.6 8.6 40 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312141 105561 None 0 Human Binding pKi = 8.6 8.6 40 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 701 11 1 7 8.5 CO/N=C(\CN(C(=O)c1cc(Cl)cc(Cl)c1)C1CC1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44315209 207369 None 0 Human Binding pKi = 8.6 8.6 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76093 207369 None 0 Human Binding pKi = 8.6 8.6 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 728 12 0 8 7.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC#N)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9979586 16816 None 0 Rat Binding pKi = 8.6 8.6 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 4 1 4 4.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(=O)c1ccccc1 10.1021/jm00019a006
CHEMBL124648 16816 None 0 Rat Binding pKi = 8.6 8.6 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 421 4 1 4 4.0 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1C(=O)c1ccccc1 10.1021/jm00019a006
44353064 157449 None 0 Human Binding pKi = 8.6 8.6 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 960 12 13 13 -3.9 CC(=O)N[C@@H]1[C@@H](CO)[C@H](O)[C@@H](CO)O[C@H]1NC(=O)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
CHEMBL407782 157449 None 0 Human Binding pKi = 8.6 8.6 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 960 12 13 13 -3.9 CC(=O)N[C@@H]1[C@@H](CO)[C@H](O)[C@@H](CO)O[C@H]1NC(=O)C[C@@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]2CNC(=O)C[C@H](NC1=O)C(=O)N[C@@H](Cc1c[nH]c3ccccc13)C(=O)N[C@@H](Cc1ccccc1)C(=O)N2 10.1021/jm0010217
44434205 89436 None 0 Human Binding pKi = 8.6 8.6 50 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL237048 89436 None 0 Human Binding pKi = 8.6 8.6 50 2
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 623 11 3 6 3.7 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)Cc3ccccc3C2)CC1 10.1016/j.bmcl.2007.06.053
44374598 119555 None 0 Human Binding pKi = 8.6 8.6 1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
CHEMBL345402 119555 None 0 Human Binding pKi = 8.6 8.6 1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 811 10 10 10 -1.2 CC(=O)NC1C(NC(=O)C2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)OC(CO)C(O)C1O 10.1016/s0960-894x(01)00841-1
9887650 16658 None 0 Guinea pig Binding pKi = 8.6 8.6 -1 5
The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaThe compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig trachea
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
CHEMBL124208 16658 None 0 Guinea pig Binding pKi = 8.6 8.6 -1 5
The compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig tracheaThe compound was tested for binding affinity against Tachykinin receptor 2 from guinea pig trachea
ChEMBL 407 5 1 3 4.3 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccccc1 10.1021/jm00019a006
44315572 103036 None 0 Human Binding pKi = 8.6 8.6 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306624 103036 None 0 Human Binding pKi = 8.6 8.6 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 689 11 1 7 8.3 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9918479 57629 None 0 Human Binding pKi = 8.6 8.6 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166827 57629 None 0 Human Binding pKi = 8.6 8.6 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 748 14 1 7 6.7 CN(C/C(=N\OCCCS(=O)(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71461711 79673 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CCC(=NO)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL2115072 79673 None 0 Human Binding pKi = 8.6 8.6 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 489 9 1 4 6.2 CCC(=NO)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315231 105455 None 0 Human Binding pKi = 8.6 8.6 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL311712 105455 None 0 Human Binding pKi = 8.6 8.6 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 780 13 0 8 8.8 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(Cc3ccccn3)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
10167532 93223 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2c(Cl)cccc2s1 10.1021/jm070289w
CHEMBL244363 93223 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2c(Cl)cccc2s1 10.1021/jm070289w
18393120 5262 None 0 Human Binding pKi = 7.7 7.7 10 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106404 5262 None 0 Human Binding pKi = 7.7 7.7 10 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 502 5 2 4 4.0 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCNCC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281415 99749 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 702 12 1 5 9.2 CO/N=C(\COC/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284597 99749 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 702 12 1 5 9.2 CO/N=C(\COC/C=C/c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281680 118655 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 659 11 1 6 8.2 CO/N=C(\COCc1ccc2ccc(C(F)(F)F)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34167 118655 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 659 11 1 6 8.2 CO/N=C(\COCc1ccc2ccc(C(F)(F)F)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363909 35909 None 0 Human Binding pKi = 7.7 7.7 5 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144223 35909 None 0 Human Binding pKi = 7.7 7.7 5 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 739 13 0 7 8.5 CCOC(=O)C1CCCN(C2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
23625321 92360 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 536 11 3 6 3.0 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1021/jm070289w
CHEMBL242847 92360 None 0 Human Binding pKi = 7.7 7.7 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 536 11 3 6 3.0 CC(C)(NC(=O)c1cc2ccccc2s1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1021/jm070289w
44390529 64205 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2cccc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL180877 64205 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 520 11 3 5 4.2 O=C(Nc1ccc(Oc2cccc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390606 64318 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL181050 64318 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 530 12 3 5 4.6 CCc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44390998 65610 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL183232 65610 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390535 122883 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 576 14 3 7 3.9 COc1cc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc(OC)c1 10.1016/j.bmcl.2004.11.045
CHEMBL360546 122883 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 576 14 3 7 3.9 COc1cc(COc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc(OC)c1 10.1016/j.bmcl.2004.11.045
44390588 123773 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL362201 123773 None 0 Human Binding pKi = 6.7 6.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 544 12 3 5 5.2 CC(C)c1ccc(Oc2ccc(NC(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44314597 104406 None 0 Human Binding pKi = 6.7 6.7 -3 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310019 104406 None 0 Human Binding pKi = 6.7 6.7 -3 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 599 10 0 5 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44391006 64097 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 485 11 2 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.11.045
CHEMBL180749 64097 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 485 11 2 4 3.4 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)C(c1ccccc1)c1ccccc1 10.1016/j.bmcl.2004.11.045
44390987 64465 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2004.11.045
CHEMBL181329 64465 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1cccc(-c2ccccc2)c1 10.1016/j.bmcl.2004.11.045
44390994 64857 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181998 64857 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391145 122497 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
CHEMBL360085 122497 None 0 Human Binding pKi = 5.7 5.7 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 492 10 2 4 3.1 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)N1CCC(Cc2ccccc2)CC1 10.1016/j.bmcl.2004.11.045
3198 207971 None 50 Human Binding pKi = 5.7 5.7 -21 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 207971 None 50 Human Binding pKi = 5.7 5.7 -21 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 207971 None 50 Human Binding pKi = 5.7 5.7 -21 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
44329015 210440 None 0 Golden hamster Binding pKi = 4.7 4.7 - 1
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 384 4 2 6 3.6 O=C(O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
CHEMBL97204 210440 None 0 Golden hamster Binding pKi = 4.7 4.7 - 1
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 384 4 2 6 3.6 O=C(O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
138106885 167007 None 49 Human Binding pKi = 5.7 5.7 -1 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
36314 167007 None 49 Human Binding pKi = 5.7 5.7 -1 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
CHEMBL428647 167007 None 49 Human Binding pKi = 5.7 5.7 -1 4
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 853 10 4 14 3.7 CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C nan
441243 9838 None 41 Human Binding pKi = 5.7 5.7 -19 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
CHEMBL114 9838 None 41 Human Binding pKi = 5.7 5.7 -19 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 670 12 5 7 3.1 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1 nan
44314533 105735 None 0 Human Binding pKi = 6.7 6.7 -2 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312539 105735 None 0 Human Binding pKi = 6.7 6.7 -2 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 710 12 0 6 7.4 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44314482 103864 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL309087 103864 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281516 99936 None 0 Human Binding pKi = 7.7 7.7 3 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL285929 99936 None 0 Human Binding pKi = 7.7 7.7 3 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1ccc(F)c2ccccc12)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281333 112786 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 611 11 1 7 7.6 CO/N=C(\COCc1ccc2sc(C)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33046 112786 None 0 Human Binding pKi = 7.7 7.7 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 611 11 1 7 7.6 CO/N=C(\COCc1ccc2sc(C)nc2c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314482 103864 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL309087 103864 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10078301 119296 None 0 Human Binding pKi = 7.7 7.7 -2 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL343447 119296 None 0 Human Binding pKi = 7.7 7.7 -2 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44314482 103864 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL309087 103864 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314482 103864 None 0 Human Binding pKi = 7.7 7.7 1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL309087 103864 None 0 Human Binding pKi = 7.7 7.7 1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10394952 104805 None 0 Human Binding pKi = 7.7 7.7 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL310703 104805 None 0 Human Binding pKi = 7.7 7.7 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 696 12 0 6 7.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
10417108 100154 None 0 Human Binding pKi = 7.7 7.7 1 2
Tested for binding affinity of compound against Tachykinin receptor 2Tested for binding affinity of compound against Tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287454 100154 None 0 Human Binding pKi = 7.7 7.7 1 2
Tested for binding affinity of compound against Tachykinin receptor 2Tested for binding affinity of compound against Tachykinin receptor 2
ChEMBL 676 11 1 5 8.7 CO/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10250427 107490 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 400 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(C)(O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318198 107490 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 400 4 3 6 4.2 CC(C)c1nc2[nH]c(N3CCC(C)(O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44266599 4648 None 0 Human Binding pKi = 6.7 6.7 -97 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 440 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10303 4648 None 0 Human Binding pKi = 6.7 6.7 -97 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 440 8 2 4 5.2 CC[C@@H](NC(=O)c1c(OCC(=O)O)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44380277 59263 None 0 Human Binding pKi = 6.7 6.7 -2 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170325 59263 None 0 Human Binding pKi = 6.7 6.7 -2 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 702 13 1 5 9.3 C=CCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314548 102964 None 0 Human Binding pKi = 6.7 6.7 -3 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306052 102964 None 0 Human Binding pKi = 6.7 6.7 -3 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 663 11 0 7 7.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(c2ncccn2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337201 108668 None 0 Human Binding pKi = 6.7 6.7 -245 3
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320548 108668 None 0 Human Binding pKi = 6.7 6.7 -245 3
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44337308 5448 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL107407 5448 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 600 7 1 4 5.6 O=C(c1cc(F)cc(F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44282003 100165 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL287523 100165 None 0 Human Binding pKi = 7.7 7.7 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 689 11 1 5 8.6 CO/N=C(\CN(C)Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9874473 41822 None 0 Human Binding pKi = 7.7 7.7 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41822 None 0 Human Binding pKi = 7.7 7.7 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
10600223 179574 None 0 Human Binding pKi = 7.7 7.7 -4 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 464 7 2 4 5.2 CC[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47408 179574 None 0 Human Binding pKi = 7.7 7.7 -4 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 464 7 2 4 5.2 CC[C@H](NC(=O)c1c(CN2CCNCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
44329340 210879 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 462 5 3 6 5.3 CC(C)c1nc2[nH]c(N3CCC(O)(c4ccccc4)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL99823 210879 None 0 Human Binding pKi = 5.7 5.7 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 462 5 3 6 5.3 CC(C)c1nc2[nH]c(N3CCC(O)(c4ccccc4)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
5354 155746 None 16 Human Binding pKi = 5.6 5.6 -25 14
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 nan
CHEMBL404849 155746 None 16 Human Binding pKi = 5.6 5.6 -25 14
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 337 12 2 3 5.6 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 nan
44380092 120425 None 0 Human Binding pKi = 7.6 7.6 -12 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL353162 120425 None 0 Human Binding pKi = 7.6 7.6 -12 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 698 12 1 6 7.2 CN(C/C(=N\OCC(C)(C)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44363436 35724 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144057 35724 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 12 0 5 9.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363949 121006 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356105 121006 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 11 0 5 8.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCC2=S)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
9874473 41822 None 0 Human Binding pKi = 7.6 7.6 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41822 None 0 Human Binding pKi = 7.6 7.6 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44383761 129885 None 0 Rat Binding pKi = 7.6 7.6 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 565 10 1 3 6.4 CC(=O)NCC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
CHEMBL367542 129885 None 0 Rat Binding pKi = 7.6 7.6 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 565 10 1 3 6.4 CC(=O)NCC1(c2ccccc2)CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/S0960-894X(00)80694-0
86274490 159980 None 0 Human Binding pKi = 4.6 4.6 -1148 3
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4106866 159980 None 0 Human Binding pKi = 4.6 4.6 -1148 3
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)[C@@H]3C)n1 nan
10044833 107503 None 0 Human Binding pKi = 5.6 5.6 -43 2
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318254 107503 None 0 Human Binding pKi = 5.6 5.6 -43 2
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44380313 58108 None 0 Human Binding pKi = 6.6 6.6 -15 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167409 58108 None 0 Human Binding pKi = 6.6 6.6 -15 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 647 10 1 4 8.3 O=C(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
1760285 210849 None 1 Human Binding pKi = 6.6 6.6 -13 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 366 5 1 2 5.8 CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL9960 210849 None 1 Human Binding pKi = 6.6 6.6 -13 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 366 5 1 2 5.8 CC[C@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
1760287 4297 None 0 Human Binding pKi = 6.6 6.6 -2 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 366 5 1 2 5.8 CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10079 4297 None 0 Human Binding pKi = 6.6 6.6 -2 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 366 5 1 2 5.8 CC[C@@H](NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44380764 120792 None 0 Human Binding pKi = 7.6 7.6 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354822 120792 None 0 Human Binding pKi = 7.6 7.6 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 689 11 1 5 8.6 CN(C)/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
10395141 207283 None 0 Human Binding pKi = 7.6 7.6 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75367 207283 None 0 Human Binding pKi = 7.6 7.6 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 13 1 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC[C@@H](CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44302769 161771 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1350 26 11 15 6.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)/C(S)=N/c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
CHEMBL413205 161771 None 0 Human Binding pKi = 7.6 7.6 - 1
Binding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligandBinding affinity against human NK2 receptors expressed in CHO cells using [3H]GR-100679 as radioligand
ChEMBL 1350 26 11 15 6.5 CCCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CCCC(N)/C(S)=N/c1ccc2c(c1)C(=O)OC21c2ccc(O)cc2Oc2cc(O)ccc21)NC(=O)c1ccccc1)C(N)=O 10.1021/jm00039a012
23625324 92416 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 2 6 3.9 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
CHEMBL243071 92416 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 2 6 3.9 CN(C(=O)c1cc2ccccc2s1)C1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1 10.1021/jm070289w
44305818 14801 None 0 Human Binding pKi = 5.6 5.6 -630 4
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14801 None 0 Human Binding pKi = 5.6 5.6 -630 4
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14801 None 0 Human Binding pKi = 5.6 5.6 -630 4
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
73350089 89442 None 0 Human Binding pKi = 5.6 5.6 -19 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
CHEMBL2370510 89442 None 0 Human Binding pKi = 5.6 5.6 -19 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 816 9 8 9 0.5 CCC(C)Cc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1OC 10.1021/jm00029a007
44380289 120319 None 0 Human Binding pKi = 7.6 7.6 -14 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352364 120319 None 0 Human Binding pKi = 7.6 7.6 -14 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 734 14 0 7 7.7 CN(C/C(=N\OCCCn1cccn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44281784 113557 None 0 Human Binding pKi = 7.6 7.6 6 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33198 113557 None 0 Human Binding pKi = 7.6 7.6 6 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 690 10 1 6 8.3 CO/N=C(\COC(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44434189 168929 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL437777 168929 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 11 3 6 3.9 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577884 170876 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 604 12 3 6 3.7 COc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL445284 170876 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 604 12 3 6 3.7 COc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577896 171014 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2008.06.102
CHEMBL445493 171014 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2008.06.102
44421492 137359 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 939 14 12 12 -2.4 CC(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL375214 137359 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 939 14 12 12 -2.4 CC(=O)N[C@@H](CC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(C)=O)C(=O)N[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
23625786 86011 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 3 6 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ncccc2c1 10.1021/jm070289w
CHEMBL230326 86011 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 557 11 3 6 2.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1ccc2ncccc2c1 10.1021/jm070289w
44390560 65414 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 570 11 3 5 5.1 O=C(Nc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182947 65414 None 0 Human Binding pKi = 6.6 6.6 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 570 11 3 5 5.1 O=C(Nc1ccc(Oc2ccc(C(F)(F)F)cc2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
10077178 103236 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 592 12 0 8 5.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
CHEMBL308176 103236 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 592 12 0 8 5.0 CCOC(=O)C1=C(C)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
86274727 160877 None 0 Human Binding pKi = 4.6 4.6 -1047 3
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4114280 160877 None 0 Human Binding pKi = 4.6 4.6 -1047 3
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)[C@@H]3C)n1 nan
44434177 89212 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 13 4 5 4.7 NCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236661 89212 None 0 Human Binding pKi = 6.6 6.6 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 548 13 4 5 4.7 NCCCCCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44329148 108996 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 359 7 4 6 3.6 CC(C)c1nc2[nH]c(NCCCN)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL321137 108996 None 0 Human Binding pKi = 5.6 5.6 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 359 7 4 6 3.6 CC(C)c1nc2[nH]c(NCCCN)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44314298 207600 None 0 Human Binding pKi = 6.6 6.6 -4 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78065 207600 None 0 Human Binding pKi = 6.6 6.6 -4 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 13 1 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NC2CC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44363990 16319 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL122643 16319 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 749 14 0 5 9.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CC3CC3)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44363912 118821 None 0 Human Binding pKi = 7.6 7.6 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL341843 118821 None 0 Human Binding pKi = 7.6 7.6 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 12 0 5 8.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
49863734 15339 None 0 Rat Binding pKi = 7.6 7.6 -13 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
CHEMBL1214027 15339 None 0 Rat Binding pKi = 7.6 7.6 -13 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1477 21 11 14 6.8 CCCC[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC(C)(C)[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)NCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm100157m
44314299 207603 None 0 Human Binding pKi = 7.6 7.6 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78070 207603 None 0 Human Binding pKi = 7.6 7.6 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 739 13 1 7 5.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC[C@H]2C(N)=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
52918298 58504 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683150 58504 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 631 14 3 6 4.4 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)nc1 10.1016/j.bmcl.2011.01.074
44314578 207606 None 0 Human Binding pKi = 6.6 6.6 -13 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL78091 207606 None 0 Human Binding pKi = 6.6 6.6 -13 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 14 1 7 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)NCC2CCCO2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44337289 108094 None 0 Human Binding pKi = 7.6 7.6 -3 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL319474 108094 None 0 Human Binding pKi = 7.6 7.6 -3 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 624 9 1 6 5.3 COc1cc(OC)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44363963 121341 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL357853 121341 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 724 13 1 6 7.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(C(N)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44337370 107472 None 0 Human Binding pKi = 6.6 6.6 -147 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL318081 107472 None 0 Human Binding pKi = 6.6 6.6 -147 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 700 7 1 4 7.3 O=C(c1cc(C(F)(F)F)cc(C(F)(F)F)c1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)[C@@H](c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL2112592 211699 None 0 Human Binding pKi = 4.6 4.6 1 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
10837820 179340 None 0 Human Binding pKi = 6.6 6.6 -38 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 463 7 1 3 6.8 CC[C@H](NC(=O)c1c(CN2CCCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47275 179340 None 0 Human Binding pKi = 6.6 6.6 -38 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 463 7 1 3 6.8 CC[C@H](NC(=O)c1c(CN2CCCCC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
2131 3499 None 46 Human Binding pKi = 6.6 6.6 -34 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
6604009 3499 None 46 Human Binding pKi = 6.6 6.6 -34 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
CHEMBL10284 3499 None 46 Human Binding pKi = 6.6 6.6 -34 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 380 5 1 2 6.1 CC[C@@H](c1ccccc1)NC(=O)c1c(C)c(nc2c1cccc2)c1ccccc1 10.1021/jm9602423
10619783 4684 None 1 Human Binding pKi = 6.6 6.6 -5 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 380 5 1 2 6.1 CC[C@@H](NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL10334 4684 None 1 Human Binding pKi = 6.6 6.6 -5 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 380 5 1 2 6.1 CC[C@@H](NC(=O)c1c(C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44337324 6713 None 0 Human Binding pKi = 7.6 7.6 2 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108364 6713 None 0 Human Binding pKi = 7.6 7.6 2 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 688 8 3 5 5.3 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@H](N)Cc4c[nH]c5ccccc45)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281771 99694 None 0 Human Binding pKi = 7.6 7.6 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284269 99694 None 0 Human Binding pKi = 7.6 7.6 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 630 14 1 8 6.7 CO/N=C(\COCc1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363962 35939 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
CHEMBL144249 35939 None 0 Human Binding pKi = 7.6 7.6 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 753 14 0 7 8.7 CCOC(=O)C1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1 10.1016/s0960-894x(00)00702-2
44314871 105749 None 0 Human Binding pKi = 7.6 7.6 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312573 105749 None 0 Human Binding pKi = 7.6 7.6 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 0 7 6.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
23625783 92915 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 663 11 4 5 3.5 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(I)cc2)CCCC1 10.1021/jm070289w
CHEMBL243933 92915 None 0 Human Binding pKi = 7.6 7.6 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 663 11 4 5 3.5 O=C(NCCCN1CCOCC1)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=S)Nc2ccc(I)cc2)CCCC1 10.1021/jm070289w
86275688 148395 None 0 Human Binding pKi = 4.6 4.6 -1071 3
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
CHEMBL3936869 148395 None 0 Human Binding pKi = 4.6 4.6 -1071 3
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 408 2 0 7 3.6 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(Cl)c2)C3C)n1 nan
44329339 112669 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 406 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL330220 112669 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 406 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(C(F)(F)F)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44281744 113537 None 0 Human Binding pKi = 6.5 6.5 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33194 113537 None 0 Human Binding pKi = 6.5 6.5 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 739 11 1 6 7.8 CO/N=C(\CN(C)S(=O)(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2683 102943 None 17 Human Binding pKi = 5.5 5.5 -398 16
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL305906 102943 None 17 Human Binding pKi = 5.5 5.5 -398 16
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
CHEMBL334255 102943 None 17 Human Binding pKi = 5.5 5.5 -398 16
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 304 15 0 0 6.5 CCCCCCCCCCCCCCCC[n+]1ccccc1 nan
4529080 167591 None 5 Human Binding pKi = 5.5 5.5 -93 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
CHEMBL429951 167591 None 5 Human Binding pKi = 5.5 5.5 -93 2
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm9602423
4529080 167591 None 5 Human Binding pKi = 5.5 5.5 -93 2
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
CHEMBL429951 167591 None 5 Human Binding pKi = 5.5 5.5 -93 2
Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.Inhibition of [125I]neurokinin A (NKA) binding in human Tachykinin receptor 2 of chinese hamster ovary (hNK-2-CHO) cell membranes.
ChEMBL 396 5 1 4 4.5 COC(=O)C(NC(=O)c1cc(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm960818o
44329600 4216 None 0 Golden hamster Binding pKi = 4.5 4.5 - 1
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 340 3 1 5 3.9 Clc1ccc(Nc2nc(N3CCOCC3)nc3ccccc23)cc1 10.1016/0960-894X(95)00502-K
CHEMBL100264 4216 None 0 Golden hamster Binding pKi = 4.5 4.5 - 1
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 340 3 1 5 3.9 Clc1ccc(Nc2nc(N3CCOCC3)nc3ccccc23)cc1 10.1016/0960-894X(95)00502-K
44337173 6691 None 0 Human Binding pKi = 8.5 8.5 30 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL108350 6691 None 0 Human Binding pKi = 8.5 8.5 30 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 582 7 2 5 4.6 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ncc[nH]4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281650 113861 None 0 Human Binding pKi = 8.5 8.5 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33243 113861 None 0 Human Binding pKi = 8.5 8.5 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 651 11 1 7 6.5 CO/N=C(\CN(C)C(=O)c1cc(C)nc(N2CCCC2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44282002 125573 None 0 Human Binding pKi = 8.5 8.5 4 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL36462 125573 None 0 Human Binding pKi = 8.5 8.5 4 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 657 13 1 8 6.3 CO/N=C(\CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9810288 206149 None 0 Guinea pig Binding pKi = 8.5 8.5 -8 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
CHEMBL67508 206149 None 0 Guinea pig Binding pKi = 8.5 8.5 -8 2
In vitro binding to Tachykinin receptor 2In vitro binding to Tachykinin receptor 2
ChEMBL 697 12 1 6 6.1 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCC(CC(N)=O)C2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00340-2
44315421 105784 None 0 Human Binding pKi = 8.5 8.5 -2 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL312612 105784 None 0 Human Binding pKi = 8.5 8.5 -2 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 765 14 1 8 7.4 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
44380090 120784 None 0 Human Binding pKi = 8.5 8.5 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354771 120784 None 0 Human Binding pKi = 8.5 8.5 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 13 0 6 7.0 COCCO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
25109291 191495 None 6 Human Binding pKi = 8.5 8.5 -72 12
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
CHEMBL519240 191495 None 6 Human Binding pKi = 8.5 8.5 -72 12
Displacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptorDisplacement of radiolabeled [Nle10]-NKA(4-10) from human NK2 receptor
ChEMBL 327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1 10.1021/jm8007618
44577892 171926 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 620 12 3 6 4.4 CSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL446853 171926 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 620 12 3 6 4.4 CSc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
11285910 142126 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 727 8 5 7 1.1 CS(=O)(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL387700 142126 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 727 8 5 7 1.1 CS(=O)(=O)N1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
11181079 163654 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
CHEMBL420308 163654 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm040832y
11296497 169014 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
CHEMBL438559 169014 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm040832y
23626109 166785 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 4 6 3.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(O)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL428217 166785 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 11 4 6 3.6 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCC(O)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
44342780 110213 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 604 6 6 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CN1 10.1021/jm011127h
CHEMBL323677 110213 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 604 6 6 4 3.0 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2c[nH]c3ccccc23)CN1 10.1021/jm011127h
44343083 110450 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 585 6 5 5 2.6 O=C1CCC(=O)N[C@@H](CC2CNc3ccc(F)cc32)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
CHEMBL324313 110450 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 585 6 5 5 2.6 O=C1CCC(=O)N[C@@H](CC2CNc3ccc(F)cc32)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CN1 10.1021/jm011127h
11181079 163654 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL420308 163654 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
11296497 169014 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm011127h
CHEMBL438559 169014 None 0 Human Binding pKi = 8.5 8.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 580 6 6 5 1.5 N[C@H]1CC(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O 10.1021/jm011127h
44380131 57630 None 0 Human Binding pKi = 8.5 8.5 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166828 57630 None 0 Human Binding pKi = 8.5 8.5 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 746 14 0 7 6.8 CN(C/C(=N\OCCCS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44337330 5334 None 0 Human Binding pKi = 8.5 8.5 6 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL106816 5334 None 0 Human Binding pKi = 8.5 8.5 6 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 649 8 2 5 4.8 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(C(=O)[C@@H](N)Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
53322827 58502 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 657 12 3 6 4.6 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1F 10.1016/j.bmcl.2011.01.074
CHEMBL1683148 58502 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 657 12 3 6 4.6 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1F 10.1016/j.bmcl.2011.01.074
44337266 5300 None 0 Human Binding pKi = 8.5 8.5 27 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
CHEMBL106608 5300 None 0 Human Binding pKi = 8.5 8.5 27 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 564 7 1 4 5.3 O=C(c1ccccc1)N1CCN(C(=O)CNC2CCN(Cc3ccccc3)CC2)C(c2ccc(Cl)c(Cl)c2)C1 10.1016/s0960-894x(02)00645-5
44337313 108659 None 0 Human Binding pKi = 8.5 8.5 7 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL320487 108659 None 0 Human Binding pKi = 8.5 8.5 7 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)[C@H](c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44380132 96480 None 0 Human Binding pKi = 8.5 8.5 -4 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL262053 96480 None 0 Human Binding pKi = 8.5 8.5 -4 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 730 14 0 6 7.2 CN(C/C(=N\OCCC[S+](C)[O-])C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9914111 199155 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56481 199155 None 0 Human Binding pKi = 8.5 8.5 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 1 3 6.5 CCC(O)(CC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315590 167911 None 0 Human Binding pKi = 8.4 8.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
CHEMBL430609 167911 None 0 Human Binding pKi = 8.4 8.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 774 14 1 8 7.5 CCNC(=O)Cn1c(=O)n(C2CCN(CC[C@@H](/C(CN(CC)C(=O)c3cc(Cl)cc(Cl)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)c2ccccc21 10.1016/s0960-894x(02)00462-6
22405764 199605 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 490 10 1 3 6.1 CCCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56788 199605 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 490 10 1 3 6.1 CCCC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
23626252 92614 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 12 4 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL243278 92614 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 576 12 4 6 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC2CCOCC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
23625637 151015 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 613 11 4 5 3.8 Cc1cc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)ccc1Br 10.1021/jm070289w
CHEMBL395774 151015 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 613 11 4 5 3.8 Cc1cc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)ccc1Br 10.1021/jm070289w
10025437 15648 None 0 Rat Binding pKi = 8.4 8.4 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1 10.1021/jm00019a006
CHEMBL122169 15648 None 0 Rat Binding pKi = 8.4 8.4 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 425 5 1 3 4.5 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1 10.1021/jm00019a006
10048714 16600 None 0 Rat Binding pKi = 8.4 8.4 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 437 6 1 4 4.3 COc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL124013 16600 None 0 Rat Binding pKi = 8.4 8.4 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 437 6 1 4 4.3 COc1ccc(CN2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44301859 202268 None 0 Rat Binding pKi = 8.4 8.4 35481 2
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL59413 202268 None 0 Rat Binding pKi = 8.4 8.4 35481 2
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 400 6 2 3 3.5 [O-][S@+](CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
10305816 4220 None 1 Human Binding pKi = 8.4 8.4 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL100298 4220 None 1 Human Binding pKi = 8.4 8.4 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 736 16 2 6 6.9 O=C(c1ccccc1C(=O)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCSCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434193 88605 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
CHEMBL235431 88605 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 589 11 3 6 3.8 CN1CCN(CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(NC(=O)c3cc4ccccc4s3)CCCCC2)CC1 10.1016/j.bmcl.2007.06.053
44434185 89547 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL237304 89547 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 560 11 3 5 4.7 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44577887 169729 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL443691 169729 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 646 15 3 6 4.9 CCCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577897 170037 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccccc1F)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
CHEMBL444142 170037 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 12 3 5 4.3 O=C(/C=C/c1ccccc1F)NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1 10.1016/j.bmcl.2008.06.102
44577888 173979 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL453961 173979 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 618 13 3 6 4.1 CCOc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
71449112 78930 None 0 Human Binding pKi = 8.4 8.4 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL2112926 78930 None 0 Human Binding pKi = 8.4 8.4 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 682 10 8 7 0.3 O=C1CC(C(=O)NC(CO)CO)C(=O)NC[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
53326714 58501 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 673 12 3 6 5.2 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1Cl 10.1016/j.bmcl.2011.01.074
CHEMBL1683147 58501 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 673 12 3 6 5.2 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NCC2CCN(CC3CCOCC3)CC2)CCCC1)c1ccc(-n2cccc2)cc1Cl 10.1016/j.bmcl.2011.01.074
44421495 85203 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 920 15 14 15 -4.1 O=C1CC(NC(=O)[C@@H](O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
CHEMBL225264 85203 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 920 15 14 15 -4.1 O=C1CC(NC(=O)[C@@H](O)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O)[C@@H](O)CO)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm040832y
10372391 9851 None 0 Human Binding pKi = 8.4 8.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 679 9 9 6 0.1 N=C(N)NCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
CHEMBL114068 9851 None 0 Human Binding pKi = 8.4 8.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 679 9 9 6 0.1 N=C(N)NCC(=O)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1021/jm011127h
44342904 10529 None 0 Human Binding pKi = 8.4 8.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 676 9 6 9 0.3 O=C(Cn1cnnn1)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)NC1=O 10.1021/jm011127h
CHEMBL116871 10529 None 0 Human Binding pKi = 8.4 8.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 676 9 6 9 0.3 O=C(Cn1cnnn1)N[C@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)NC1=O 10.1021/jm011127h
44314502 207255 None 0 Human Binding pKi = 7.5 7.5 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL75018 207255 None 0 Human Binding pKi = 7.5 7.5 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 712 12 1 7 5.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
23625326 149467 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1sc2ccccc2c1Cl 10.1021/jm070289w
CHEMBL394543 149467 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 596 11 3 6 4.2 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1sc2ccccc2c1Cl 10.1021/jm070289w
44391011 64392 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181291 64392 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1cccc(Oc2ccccc2)c1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44337467 110271 None 0 Human Binding pKi = 6.5 6.5 -17 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
CHEMBL323741 110271 None 0 Human Binding pKi = 6.5 6.5 -17 2
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 821 13 2 7 7.8 O=C(CN(NC1CCN(Cc2ccccc2)CC1)NC1CCN(Cc2ccccc2)CC1)N1CCN(Cc2cc(C(F)(F)F)cc(C(F)(F)F)c2)CC1c1ccccc1 10.1016/s0960-894x(02)00645-5
44391005 122397 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL359885 122397 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 438 10 2 4 2.3 CN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391123 122425 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.045
CHEMBL360023 122425 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 471 10 2 4 3.5 O=C(N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1)c1ccccc1-c1ccccc1 10.1016/j.bmcl.2004.11.045
86275685 145366 None 0 Human Binding pKi = 4.5 4.5 -416 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)C3C)n1 nan
CHEMBL3913001 145366 None 0 Human Binding pKi = 4.5 4.5 -416 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(F)c(Cl)c2)C3C)n1 nan
10022196 210746 None 0 Human Binding pKi = 5.5 5.5 -45 2
Inhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cellsInhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL98977 210746 None 0 Human Binding pKi = 5.5 5.5 -45 2
Inhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cellsInhibition constant for displacement of [3H]-NKA from the cloned human NK2 receptor which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 372 4 2 6 3.7 CC(C)c1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44314503 207451 None 0 Human Binding pKi = 7.5 7.5 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL76704 207451 None 0 Human Binding pKi = 7.5 7.5 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 698 12 1 7 5.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9931729 101047 None 0 Rat Binding pKi = 7.5 7.5 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 416 6 2 4 3.2 O=S(=O)(CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
CHEMBL294336 101047 None 0 Rat Binding pKi = 7.5 7.5 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 416 6 2 4 3.2 O=S(=O)(CC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1)c1ccccc1 10.1016/S0960-894X(01)80541-2
44301695 203846 None 0 Rat Binding pKi = 7.5 7.5 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 382 6 2 3 4.1 Cc1ccccc1OCC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/S0960-894X(01)80541-2
CHEMBL60459 203846 None 0 Rat Binding pKi = 7.5 7.5 - 1
Binding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colonBinding affinity by displacement of radiolabeled GR-100679 from Tachykinin receptor 2 from homogenized rat colon
ChEMBL 382 6 2 3 4.1 Cc1ccccc1OCC1(O)CCN(CCc2c[nH]c3ccc(F)cc23)CC1 10.1016/S0960-894X(01)80541-2
10122872 107817 None 0 Human Binding pKi = 7.5 7.5 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 704 16 2 6 5.5 O=C(c1ccccc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL319154 107817 None 0 Human Binding pKi = 7.5 7.5 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 704 16 2 6 5.5 O=C(c1ccccc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44434195 88628 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
CHEMBL235574 88628 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 652 17 3 5 6.6 CCCCN(CCCC)CCCNC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc21 10.1016/j.bmcl.2007.06.053
44434186 154883 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 12 3 5 5.3 CC(C)N(CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(C)C 10.1016/j.bmcl.2007.06.053
CHEMBL400209 154883 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 576 12 3 5 5.3 CC(C)N(CCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(C)C 10.1016/j.bmcl.2007.06.053
44391033 123625 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL361815 123625 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 487 11 2 5 3.1 CC(C)(Oc1cccc(Cl)c1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390451 166280 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 532 12 3 6 4.1 COc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL426421 166280 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 532 12 3 6 4.1 COc1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44391026 123979 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL362800 123979 None 0 Human Binding pKi = 5.5 5.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL2111789 211678 None 0 Human Binding pKi = 4.5 4.5 3 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL None None None CC(C)[C@@H]1NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)[C@H](Cc2ccc(OC(C)(C)C)cc2)NC(=O)CNC1=O 10.1021/jm00029a007
44266551 98381 None 0 Human Binding pKi = 6.5 6.5 -58 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 394 6 1 2 6.3 CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](CC)c1ccccc1 10.1021/jm980633c
CHEMBL275017 98381 None 0 Human Binding pKi = 6.5 6.5 -58 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 394 6 1 2 6.3 CCc1c(-c2ccccc2)nc2ccccc2c1C(=O)N[C@H](CC)c1ccccc1 10.1021/jm980633c
10626894 9924 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm0010217
CHEMBL114442 9924 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity towards Tachykinin receptor 2Binding affinity towards Tachykinin receptor 2
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm0010217
44434162 145910 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 489 8 3 4 4.3 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NC2CC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL391710 145910 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 489 8 3 4 4.3 O=C(NC1(C(=O)N[C@@H](Cc2ccccc2)C(=O)NC2CC2)CCCCC1)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434163 146948 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 11 3 5 4.1 CN(C)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL392523 146948 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 11 3 5 4.1 CN(C)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434160 167444 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL429452 167444 None 0 Human Binding pKi = 6.5 6.5 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
10626894 9924 None 0 Human Binding pKi = 6.5 6.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm011127h
CHEMBL114442 9924 None 0 Human Binding pKi = 6.5 6.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 571 6 5 4 3.3 O=C1CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](CC2CCCCC2)CN1 10.1021/jm011127h
10985363 10525 None 0 Human Binding pKi = 6.5 6.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 703 9 5 6 3.6 C=CCOC(=O)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N1 10.1021/jm011127h
CHEMBL116855 10525 None 0 Human Binding pKi = 6.5 6.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 703 9 5 6 3.6 C=CCOC(=O)[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)N1 10.1021/jm011127h
10875451 110414 None 0 Human Binding pKi = 6.5 6.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
CHEMBL324106 110414 None 0 Human Binding pKi = 6.5 6.5 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 565 6 5 4 2.6 O=C1CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
448537 160344 None 54 Human Binding pKi = 5.5 5.5 -26 25
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
CHEMBL411 160344 None 54 Human Binding pKi = 5.5 5.5 -26 25
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 268 4 2 2 4.8 CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1 nan
44390446 64485 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181359 64485 None 0 Human Binding pKi = 6.5 6.5 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 550 12 3 5 4.5 O=C(Nc1ccc(OCc2cccc(Cl)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
86275451 160187 None 0 Human Binding pKi = 4.5 4.5 -4466 3
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL4108623 160187 None 0 Human Binding pKi = 4.5 4.5 -4466 3
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 420 4 0 8 3.8 CCc1noc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
10668461 79494 None 0 Human Binding pKi = 6.5 6.5 -181 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 396 6 1 3 5.8 CC[C@H](NC(=O)c1c(OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
CHEMBL2113673 79494 None 0 Human Binding pKi = 6.5 6.5 -181 2
Binding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKBBinding affinity towards cloned human Tachykinin receptor 2 (hNK-2) expressed in CHO cells using [125I][MePhe7]-NKB
ChEMBL 396 6 1 3 5.8 CC[C@H](NC(=O)c1c(OC)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm980633c
44363936 20042 None 0 Human Binding pKi = 7.5 7.5 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL130354 20042 None 0 Human Binding pKi = 7.5 7.5 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 782 14 1 7 9.0 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(OC(=O)NC(C)C)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
10552329 168147 None 0 Human Binding pKi = 7.5 7.5 -1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 2 4 5.5 C[C@H](NC(=O)c1c(CN2CCC(N)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL432301 168147 None 0 Human Binding pKi = 7.5 7.5 -1 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 2 4 5.5 C[C@H](NC(=O)c1c(CN2CCC(N)CC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
9874473 41822 None 0 Human Binding pKi = 7.5 7.5 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41822 None 0 Human Binding pKi = 7.5 7.5 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
44314504 102971 None 0 Human Binding pKi = 7.5 7.5 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306121 102971 None 0 Human Binding pKi = 7.5 7.5 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 682 12 0 6 6.6 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
22405732 198851 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 8 1 3 5.3 CC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56274 198851 None 0 Human Binding pKi = 7.5 7.5 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 8 1 3 5.3 CC(O)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
11496610 4075 None 10 Human Binding pKi = 6.5 6.5 2 2
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
5582 4075 None 10 Human Binding pKi = 6.5 6.5 2 2
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
CHEMBL474991 4075 None 10 Human Binding pKi = 6.5 6.5 2 2
Inhibition of human neurokinin NK2 receptorInhibition of human neurokinin NK2 receptor
ChEMBL 476 4 1 5 5.8 CC(c1ccc(cc1)c1[nH]c2c(n1)cccc2N1CCN(CC1)Cc1ccc2c(c1)nccn2)(C)C 10.1021/jm801572m
73353047 89440 None 0 Human Binding pKi = 4.5 4.5 -1 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
CHEMBL2370509 89440 None 0 Human Binding pKi = 4.5 4.5 -1 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 746 6 8 9 -1.1 COc1ccc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)cc1 10.1021/jm00029a007
44281358 98316 None 0 Human Binding pKi = 6.5 6.5 -3 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL274557 98316 None 0 Human Binding pKi = 6.5 6.5 -3 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 674 11 1 4 9.5 CO/N=C(\CCCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2812 4781 None 63 Human Binding pKi = 5.5 5.5 -28 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
CHEMBL104 4781 None 63 Human Binding pKi = 5.5 5.5 -28 34
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 344 4 0 2 5.4 Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1 nan
44314868 155788 None 0 Human Binding pKi = 7.5 7.5 -3 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL405129 155788 None 0 Human Binding pKi = 7.5 7.5 -3 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CN[C@@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44314867 157419 None 0 Human Binding pKi = 7.5 7.5 -8 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL407749 157419 None 0 Human Binding pKi = 7.5 7.5 -8 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 705 13 3 5 7.1 NC(=O)CNC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44329374 210745 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 430 6 2 7 4.5 COC1(OC)CCN(c2nc(Nc3ccc(Cl)cc3)c3[nH]c(C(C)C)nc3n2)CC1 10.1016/0960-894X(95)00502-K
CHEMBL98976 210745 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 430 6 2 7 4.5 COC1(OC)CCN(c2nc(Nc3ccc(Cl)cc3)c3[nH]c(C(C)C)nc3n2)CC1 10.1016/0960-894X(95)00502-K
44329484 210427 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 344 6 3 5 4.7 CCCNc1nc(Nc2ccc(Cl)cc2)c2[nH]c(C(C)C)nc2n1 10.1016/0960-894X(95)00502-K
CHEMBL97140 210427 None 0 Human Binding pKi = 5.5 5.5 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 344 6 3 5 4.7 CCCNc1nc(Nc2ccc(Cl)cc2)c2[nH]c(C(C)C)nc2n1 10.1016/0960-894X(95)00502-K
44281572 110448 None 0 Human Binding pKi = 7.5 7.5 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32431 110448 None 0 Human Binding pKi = 7.5 7.5 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 705 10 2 6 8.7 CO/N=C(\COC(=O)Nc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
9874473 41822 None 0 Human Binding pKi = 7.5 7.5 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41822 None 0 Human Binding pKi = 7.5 7.5 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
9852904 117101 None 0 Human Binding pKi = 7.5 7.5 -128 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
CHEMBL339051 117101 None 0 Human Binding pKi = 7.5 7.5 -128 3
Inhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cellsInhibition of binding of [3H]NKA to human Tachykinin receptor 2 (NK2) expressed in mouse erythroleukemia cells
ChEMBL 677 10 1 6 5.9 CNC(=O)C1(N2CCCCC2=O)CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(C#N)cc3ccccc23)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm020094i
2110 2969 None 33 Human Binding pKi = 7.5 7.5 -138 6
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
219077 2969 None 33 Human Binding pKi = 7.5 7.5 -138 6
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
3480 2969 None 33 Human Binding pKi = 7.5 7.5 -138 6
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
CHEMBL346178 2969 None 33 Human Binding pKi = 7.5 7.5 -138 6
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
DB04872 2969 None 33 Human Binding pKi = 7.5 7.5 -138 6
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm900948q
44380474 58800 None 0 Human Binding pKi = 6.5 6.5 -13 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168769 58800 None 0 Human Binding pKi = 6.5 6.5 -13 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 678 12 2 5 8.2 CONC(COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314481 207394 None 0 Human Binding pKi = 6.5 6.5 -10 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL76334 207394 None 0 Human Binding pKi = 6.5 6.5 -10 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 662 10 2 5 8.5 O/N=C(/COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
86275686 147254 None 0 Human Binding pKi = 4.4 4.4 -851 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)C3C)n1 nan
CHEMBL3927872 147254 None 0 Human Binding pKi = 4.4 4.4 -851 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 392 2 0 7 3.1 Cc1nsc(-c2nnc3n2CCN(C(=O)c2ccc(Cl)c(F)c2)C3C)n1 nan
86274728 161050 None 0 Human Binding pKi = 4.4 4.4 -1380 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 394 2 0 7 2.7 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1 nan
CHEMBL4115594 161050 None 0 Human Binding pKi = 4.4 4.4 -1380 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 394 2 0 7 2.7 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2)[C@@H]3C)n1 nan
44314865 207571 None 0 Human Binding pKi = 6.4 6.4 -3 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77752 207571 None 0 Human Binding pKi = 6.4 6.4 -3 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 738 13 0 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N(C)C2CCCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
9874473 41822 None 0 Human Binding pKi = 7.4 7.4 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
CHEMBL149326 41822 None 0 Human Binding pKi = 7.4 7.4 -16 3
In vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligandIn vitro binding affinity towards human Tachykinin receptor 2 was determined by using [125I]NKA as a radioligand
ChEMBL 659 10 0 4 8.4 CCc1c(C#N)cc2ccccc2c1C(=O)N(C)C[C@@H](CCN1CCC(c2ccccc2[S@+](C)[O-])CC1)c1ccc(Cl)c(Cl)c1 10.1021/jm030197g
2132 3744 None 43 Human Binding pKi = 5.4 5.4 -97 6
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
5311424 3744 None 43 Human Binding pKi = 5.4 5.4 -97 6
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
CHEMBL10188 3744 None 43 Human Binding pKi = 5.4 5.4 -97 6
Binding affinity to human NK2 receptor by radioligand binding assayBinding affinity to human NK2 receptor by radioligand binding assay
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1016/j.bmcl.2011.02.033
2089 2766 None 25 Guinea pig Binding pKi = 5.4 5.4 -3548 5
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
3795 2766 None 25 Guinea pig Binding pKi = 5.4 5.4 -3548 5
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
5311311 2766 None 25 Guinea pig Binding pKi = 5.4 5.4 -3548 5
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
CHEMBL217406 2766 None 25 Guinea pig Binding pKi = 5.4 5.4 -3548 5
Evaluated for the binding affinity against NK2 receptorEvaluated for the binding affinity against NK2 receptor
ChEMBL None None None None 10.1021/jm00073a022
86274964 160441 None 0 Human Binding pKi = 4.4 4.4 -758 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1 nan
CHEMBL4110770 160441 None 0 Human Binding pKi = 4.4 4.4 -758 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 374 2 0 7 3.0 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cccc(Cl)c2)[C@@H]3C)n1 nan
44281485 115322 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 616 12 1 5 8.3 CO/N=C(\COCc1ccc(-c2ccccc2)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33479 115322 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 616 12 1 5 8.3 CO/N=C(\COCc1ccc(-c2ccccc2)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44314873 207248 None 0 Human Binding pKi = 7.4 7.4 -2 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL74918 207248 None 0 Human Binding pKi = 7.4 7.4 -2 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 726 12 1 7 6.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
73351579 89439 None 0 Human Binding pKi = 5.4 5.4 2 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
CHEMBL2370507 89439 None 0 Human Binding pKi = 5.4 5.4 2 2
Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)Displacement of [125I]-NKA substance P binding to human urinary bladder membrane protein (NK2)
ChEMBL 800 7 9 9 0.1 CC(C)=CCc1cc(C(O)C2NC(=O)CNC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@@H]3CCCN3C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)CNC2=O)ccc1O 10.1021/jm00029a007
44314945 207454 None 0 Human Binding pKi = 6.4 6.4 -9 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL76727 207454 None 0 Human Binding pKi = 6.4 6.4 -9 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 728 17 1 7 6.9 CCOCCCNC(=O)CN1CCN(CCC(/C(COCc2cc(C(F)(F)F)cc(C(F)(F)F)c2)=N/OC)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(00)00464-9
44363982 35675 None 0 Human Binding pKi = 7.4 7.4 -2 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144010 35675 None 0 Human Binding pKi = 7.4 7.4 -2 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 683 12 0 6 7.8 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCOCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44364030 36657 None 0 Human Binding pKi = 7.4 7.4 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144887 36657 None 0 Human Binding pKi = 7.4 7.4 1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(CO)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44434164 167148 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL428905 167148 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 13 3 5 4.9 CCN(CC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44380473 120848 None 0 Human Binding pKi = 6.4 6.4 -549 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL355429 120848 None 0 Human Binding pKi = 6.4 6.4 -549 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 684 12 1 6 6.5 CN(C/C(=N\OCC(=O)O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44314476 105138 None 0 Human Binding pKi = 6.4 6.4 -12 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
CHEMBL311387 105138 None 0 Human Binding pKi = 6.4 6.4 -12 2
Binding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligandBinding affinity towards Tachykinin receptor 2 in CHO cells using [3H]-neurokinin A as radioligand
ChEMBL 676 11 1 5 8.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@@H](CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00463-7
44434166 88786 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 12 4 5 4.3 NCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL236248 88786 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 534 12 4 5 4.3 NCCCCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
90663623 106766 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 628 15 4 7 3.4 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL3143849 106766 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 628 15 4 7 3.4 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCc2ccccc2C1 10.1016/j.bmcl.2007.06.053
CHEMBL117039 211020 None 0 Human Binding pKi = 6.4 6.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL None None None O=C1C[C@@H](C(=O)O)NC(=O)[C@@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1021/jm011127h
2132 3744 None 43 Human Binding pKi = 5.4 5.4 -97 6
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
5311424 3744 None 43 Human Binding pKi = 5.4 5.4 -97 6
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
CHEMBL10188 3744 None 43 Human Binding pKi = 5.4 5.4 -97 6
Displacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysisDisplacement of [125I]-neurokinin A from human NK2R after 90 mins by scintillation counting analysis
ChEMBL 382 5 2 3 5.5 CC[C@@H](c1ccccc1)NC(=O)c1c(O)c(nc2c1cccc2)c1ccccc1 10.1021/jm5017413
10875000 163967 None 0 Human Binding pKi = 5.4 5.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 518 5 6 5 -0.2 NC(=O)[C@@H]1CNC(=O)CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1 10.1021/jm011127h
CHEMBL420685 163967 None 0 Human Binding pKi = 5.4 5.4 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 518 5 6 5 -0.2 NC(=O)[C@@H]1CNC(=O)CCC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](Cc2ccccc2)C(=O)N1 10.1021/jm011127h
44315210 102973 None 0 Human Binding pKi = 8.4 8.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL306124 102973 None 0 Human Binding pKi = 8.4 8.4 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 14 0 8 8.0 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44281723 99681 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 11 1 5 8.0 CO/N=C(\COCc1ccc(C(C)(C)C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL284145 99681 None 0 Human Binding pKi = 8.4 8.4 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 11 1 5 8.0 CO/N=C(\COCc1ccc(C(C)(C)C)cc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281666 109261 None 0 Human Binding pKi = 8.4 8.4 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32163 109261 None 0 Human Binding pKi = 8.4 8.4 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 635 10 1 5 7.5 CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281958 109743 None 0 Human Binding pKi = 8.4 8.4 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32273 109743 None 0 Human Binding pKi = 8.4 8.4 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 646 10 1 6 6.4 CO/N=C(\CN(C)C(=O)c1cncc(Br)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281787 163294 None 0 Human Binding pKi = 8.4 8.4 14 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL418224 163294 None 0 Human Binding pKi = 8.4 8.4 14 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 597 11 1 6 6.2 CO/N=C(\CN(C)C(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44363908 35792 None 0 Human Binding pKi = 8.4 8.4 4 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL144116 35792 None 0 Human Binding pKi = 8.4 8.4 4 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.2 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44315589 207296 None 0 Human Binding pKi = 8.4 8.4 -2 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL75478 207296 None 0 Human Binding pKi = 8.4 8.4 -2 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44315589 207296 None 0 Human Binding pKi = 8.4 8.4 -2 3
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
CHEMBL75478 207296 None 0 Human Binding pKi = 8.4 8.4 -2 3
Displacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranesDisplacement of [3H]NKA from human NK2 receptor expressed in CHO cells membranes
ChEMBL 804 16 1 9 7.2 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)NCCOC)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1021/acs.jmedchem.9b00017
23625634 92633 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 567 12 4 6 3.4 CSc1ccc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc1 10.1021/jm070289w
CHEMBL243503 92633 None 0 Human Binding pKi = 8.4 8.4 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 567 12 4 6 3.4 CSc1ccc(NC(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)CCCC2)cc1 10.1021/jm070289w
44380414 58172 None 0 Human Binding pKi = 8.4 8.4 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167994 58172 None 0 Human Binding pKi = 8.4 8.4 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 699 12 2 7 5.9 CN(C/C(=N\OCC(=O)NO)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
9956370 173826 None 0 Human Binding pKi = 8.4 8.4 53 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 1 4 5.5 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NC2CCCCC2)CC1 10.1021/jm000501v
CHEMBL45362 173826 None 0 Human Binding pKi = 8.4 8.4 53 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 470 6 1 4 5.5 CC(C)N1CCN(Cc2c(-c3ccccc3)nc3ccccc3c2C(=O)NC2CCCCC2)CC1 10.1021/jm000501v
44380279 57836 None 0 Human Binding pKi = 8.4 8.4 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL166975 57836 None 0 Human Binding pKi = 8.4 8.4 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 761 15 1 7 6.3 CN(C/C(=N\OCCCNS(C)(=O)=O)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
49863732 15337 None 0 Rat Binding pKi = 8.4 8.4 -24 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
CHEMBL1214025 15337 None 0 Rat Binding pKi = 8.4 8.4 -24 4
Displacement of [3H]substance P frome rat NK2 receptorDisplacement of [3H]substance P frome rat NK2 receptor
ChEMBL 1266 18 10 12 6.1 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(C)(C)SSC1(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCc1cc(C(F)(F)F)cc(C(F)(F)F)c1 10.1021/jm100157m
53325456 58503 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2011.01.074
CHEMBL1683149 58503 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2011.01.074
11800732 180702 None 0 Human Binding pKi = 8.3 8.3 -3 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47544 180702 None 0 Human Binding pKi = 8.3 8.3 -3 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 546 8 1 4 7.2 CC[C@H](NC(=O)c1c(CN2CCC(N3CCCCC3)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
23626411 92265 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL242624 92265 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 673 12 3 7 3.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCC(=O)N2CCC(N3CCOCC3)CC2)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10392319 198655 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 532 12 1 3 7.3 CCCC(O)(CCC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL56143 198655 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 532 12 1 3 7.3 CCCC(O)(CCC)C1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
44315591 207432 None 0 Human Binding pKi = 8.3 8.3 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL76529 207432 None 0 Human Binding pKi = 8.3 8.3 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 746 13 1 8 6.9 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(N)=O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
44380337 57452 None 0 Human Binding pKi = 8.3 8.3 -6 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL165465 57452 None 0 Human Binding pKi = 8.3 8.3 -6 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 735 14 0 8 7.1 CN(C/C(=N\OCCCn1cncn1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
23626254 93274 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 594 16 6 7 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CCO)CCO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL244766 93274 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 594 16 6 7 2.9 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCNC(CCO)CCO)CCCC1)c1cc2ccccc2s1 10.1021/jm070289w
10280686 143164 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 546 11 3 6 3.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2o1 10.1021/jm070289w
CHEMBL389525 143164 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 546 11 3 6 3.0 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CCCC1)c1cc2ccccc2o1 10.1021/jm070289w
44315573 103851 None 0 Human Binding pKi = 8.3 8.3 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL308983 103851 None 0 Human Binding pKi = 8.3 8.3 -1 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 707 12 1 7 8.3 CO/N=C(\CN(CCF)C(=O)c1cc(Cl)cc(Cl)c1)[C@H](CCN1CCC(n2c(O)nc3ccccc32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00462-6
10145229 9175 None 0 Human Binding pKi = 8.3 8.3 -2 4
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
CHEMBL110219 9175 None 0 Human Binding pKi = 8.3 8.3 -2 4
Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.Binding affinity in membrane preparations containing recombinant human Tachykinin receptor 2 in CHO cells by using [3H]NKA as the radioligand.
ChEMBL 592 7 1 4 5.9 Cc1cc(C)cc(C(=O)N2CCN(C(=O)CNC3CCN(Cc4ccccc4)CC3)C(c3ccc(Cl)c(Cl)c3)C2)c1 10.1016/s0960-894x(02)00645-5
44281726 109584 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 540 11 1 5 6.7 CO/N=C(\COCc1ccccc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32215 109584 None 0 Human Binding pKi = 7.4 7.4 - 1
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 540 11 1 5 6.7 CO/N=C(\COCc1ccccc1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
22405761 200745 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 0 4 5.9 CC(=O)OCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
CHEMBL57589 200745 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 504 10 0 4 5.9 CC(=O)OCCC1CCN(CCC(CN(C)C(=O)c2ccccc2)c2ccc(Cl)c(Cl)c2)CC1 10.1016/s0960-894x(98)00037-7
2110 2969 None 33 Human Binding pKi = 7.4 7.4 -138 6
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
219077 2969 None 33 Human Binding pKi = 7.4 7.4 -138 6
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
3480 2969 None 33 Human Binding pKi = 7.4 7.4 -138 6
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
CHEMBL346178 2969 None 33 Human Binding pKi = 7.4 7.4 -138 6
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
DB04872 2969 None 33 Human Binding pKi = 7.4 7.4 -138 6
Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)Binding Affinity of [125I]NKA towards Tachykinin receptor 2-CHO cell membranes (n=3-8)
ChEMBL 605 8 0 3 7.4 O=C(N1CCC[C@](C1)(CCCN1CCC(CC1)(c1ccccc1)N(C(=O)C)C)c1ccc(c(c1)Cl)Cl)c1ccccc1 10.1021/jm9602423
44312828 104415 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 640 12 0 8 6.1 CC1=C(C(=O)Oc2ccccc2)[S+]([O-])C2C(O1)OC(COCc1ccccc1)C(OCc1ccccc1)C2OCc1ccccc1 10.1016/s0960-894x(02)00471-7
CHEMBL310084 104415 None 0 Human Binding pKi = 6.4 6.4 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 640 12 0 8 6.1 CC1=C(C(=O)Oc2ccccc2)[S+]([O-])C2C(O1)OC(COCc1ccccc1)C(OCc1ccccc1)C2OCc1ccccc1 10.1016/s0960-894x(02)00471-7
44312485 207097 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
CHEMBL73540 207097 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 486 9 1 8 3.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2S1 10.1016/s0960-894x(02)00471-7
44312718 207243 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
CHEMBL74882 207243 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 502 9 1 8 2.8 CCOC(=O)C1=C(C)OC2OC(CO)C(OCc3ccccc3)C(OCc3ccccc3)C2[S+]1[O-] 10.1016/s0960-894x(02)00471-7
44314577 159974 None 0 Human Binding pKi = 6.4 6.4 -16 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL41068 159974 None 0 Human Binding pKi = 6.4 6.4 -16 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 782 14 0 8 7.1 CCOC(=O)C1CCN(C(=O)CN2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/s0960-894x(00)00464-9
CHEMBL4521971 216442 None 43 Human Binding pKi = 5.4 5.4 -338 5
Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b TACR2Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b TACR2
ChEMBL None None None Clc1cc2c(NC3CCCC3)nnc(-c3ccncc3)c2cc1Cl 10.6019/CHEMBL5212743
2750 206519 None 50 Human Binding pKi = 5.4 5.4 -2 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
CHEMBL7002 206519 None 50 Human Binding pKi = 5.4 5.4 -2 12
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 333 5 1 4 3.9 CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1 nan
44380596 59370 None 0 Human Binding pKi = 7.4 7.4 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL170727 59370 None 0 Human Binding pKi = 7.4 7.4 1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 706 13 1 6 8.7 COCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44281505 116954 None 0 Human Binding pKi = 7.4 7.4 2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33833 116954 None 0 Human Binding pKi = 7.4 7.4 2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 576 11 1 5 6.9 CO/N=C(\COCc1cc(F)cc(F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
2090 2767 None 27 Human Binding pKi = 7.4 7.4 -38 4
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
5311312 2767 None 27 Human Binding pKi = 7.4 7.4 -38 4
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
CHEMBL437797 2767 None 27 Human Binding pKi = 7.4 7.4 -38 4
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None None 10.1021/jm9807151
9940831 14652 None 0 Human Binding pKi = 5.4 5.4 -912 4
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14652 None 0 Human Binding pKi = 5.4 5.4 -912 4
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14652 None 0 Human Binding pKi = 5.4 5.4 -912 4
Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.Binding affinity for NK-2 receptor was determined in a radioligand binding assay using chinese hamster ovary cells.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
44281334 119458 None 0 Human Binding pKi = 7.4 7.4 2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL34460 119458 None 0 Human Binding pKi = 7.4 7.4 2 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 541 11 1 6 6.1 CO/N=C(\COCc1ccccn1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44329530 112468 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 428 4 2 7 4.2 CC(C)c1nc2[nH]c(N3CCC4(CC3)OCCO4)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL329749 112468 None 0 Human Binding pKi = 5.4 5.4 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 428 4 2 7 4.2 CC(C)c1nc2[nH]c(N3CCC4(CC3)OCCO4)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL103634 210917 None 0 Human Binding pKi = 7.4 7.4 - 1
The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2The compound was tested for competition binding with [3H]NKA against the CHO cells from cloned human Tachykinin receptor 2
ChEMBL None None None CC(C)CC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)O)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm9807151
52918299 58508 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1c(C(=O)NC2(C(=O)N[C@H](CCCN3CCN(CC4CCOCC4)CC3)Cc3ccccc3)CCCC2)ccc2ccccc12 10.1016/j.bmcl.2011.01.074
CHEMBL1683154 58508 None 0 Human Binding pKi = 7.4 7.4 - 1
Displacement of [125I]neurokinin A from human NK2 receptor after 30 minsDisplacement of [125I]neurokinin A from human NK2 receptor after 30 mins
ChEMBL 640 13 2 6 5.4 COc1c(C(=O)NC2(C(=O)N[C@H](CCCN3CCN(CC4CCOCC4)CC3)Cc3ccccc3)CCCC2)ccc2ccccc12 10.1016/j.bmcl.2011.01.074
44380093 120800 None 0 Human Binding pKi = 7.4 7.4 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL354892 120800 None 0 Human Binding pKi = 7.4 7.4 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 733 13 2 6 7.8 CNC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
11734825 13232 None 0 Human Binding pKi = 6.3 6.3 -549 2
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
CHEMBL119126 13232 None 0 Human Binding pKi = 6.3 6.3 -549 2
In vitro binding affinity towards Human Tachykinin receptor 2In vitro binding affinity towards Human Tachykinin receptor 2
ChEMBL 623 7 2 3 6.1 CN(C(=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](/C=C/C(=O)N[C@@H]1CCCCNC1=O)Cc1ccc(Cl)c(Cl)c1 10.1021/jm030786m
44363978 40503 None 0 Human Binding pKi = 7.3 7.3 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL148282 40503 None 0 Human Binding pKi = 7.3 7.3 -1 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 697 12 1 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCC(O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
22405743 100751 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 9 1 3 5.3 CN(CC(CCN1CCC(CCO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
CHEMBL292415 100751 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of [3H]- NKA from human NK-2 receptor expressed in MEL cellsDisplacement of [3H]- NKA from human NK-2 receptor expressed in MEL cells
ChEMBL 462 9 1 3 5.3 CN(CC(CCN1CCC(CCO)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/s0960-894x(98)00037-7
44314732 207552 None 0 Human Binding pKi = 6.3 6.3 -3 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL77592 207552 None 0 Human Binding pKi = 6.3 6.3 -3 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 764 12 0 6 8.5 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCC3CCCCC32)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44380413 96649 None 0 Human Binding pKi = 7.3 7.3 -21 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL263214 96649 None 0 Human Binding pKi = 7.3 7.3 -21 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 741 15 1 7 6.2 COCCNC(=O)CO/N=C(\CN(C)C(=O)c1cc(Cl)cc(Cl)c1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44314487 102968 None 0 Human Binding pKi = 7.3 7.3 -5 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL306097 102968 None 0 Human Binding pKi = 7.3 7.3 -5 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 753 13 1 7 6.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCC(NC(C)=O)C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
6518171 168399 None 38 Human Binding pKi = 5.3 5.3 -4 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
CHEMBL434063 168399 None 38 Human Binding pKi = 5.3 5.3 -4 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 495 12 2 6 4.9 CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1)c1ccccn1 nan
86274731 160767 None 0 Human Binding pKi = 4.3 4.3 -1584 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 412 2 0 7 2.9 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1 nan
CHEMBL4113428 160767 None 0 Human Binding pKi = 4.3 4.3 -1584 2
Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK-2 receptor was evaluated in CHO recombinant cells which express the human NK-2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 412 2 0 7 2.9 Cc1nsc(-c2nnc3n2CCN(C(=O)c2cc(F)c(F)c(F)c2F)[C@@H]3C)n1 nan
3561 19084 None 29 Human Binding pKi = 6.3 6.3 -1 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
CHEMBL1289 19084 None 29 Human Binding pKi = 6.3 6.3 -1 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 360 2 0 1 4.4 Clc1cc(Cl)c(OCC#CI)cc1Cl nan
71461646 78940 None 0 Human Binding pKi = 8.3 8.3 -2 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2112941 78940 None 0 Human Binding pKi = 8.3 8.3 -2 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 676 11 0 5 7.6 CN(C/C(=N\OC(F)F)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL2390989 212870 None 17 Human Binding pKi = 8.3 8.3 - 1
Binding affinity to human NK2 receptor by radioligand displacement assayBinding affinity to human NK2 receptor by radioligand displacement assay
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(N)=O 10.1016/j.ejmech.2013.01.044
10390024 17961 None 0 Rat Binding pKi = 8.3 8.3 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 471 5 1 5 3.8 Cc1ccc(S(=O)(=O)N2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
CHEMBL126043 17961 None 0 Rat Binding pKi = 8.3 8.3 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 471 5 1 5 3.8 Cc1ccc(S(=O)(=O)N2CC3(CCN(CCc4c[nH]c5ccc(F)cc45)CC3)OC2=O)cc1 10.1021/jm00019a006
44577886 172028 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
CHEMBL447011 172028 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 632 14 3 6 4.5 CCCOc1cccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)c1 10.1016/j.bmcl.2008.06.102
44577895 188981 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
CHEMBL507077 188981 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]NKA from human NK2 receptor expressed in CHOK1 cells
ChEMBL 630 14 3 5 5.1 CCCCc1ccc(C(=O)NC2(C(=O)N[C@H](Cc3ccccc3)C(=O)NCC3CCN(CC4CCOCC4)CC3)CCCC2)cc1 10.1016/j.bmcl.2008.06.102
44374543 52911 None 0 Human Binding pKi = 8.3 8.3 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
CHEMBL159585 52911 None 0 Human Binding pKi = 8.3 8.3 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 773 9 5 6 3.7 O=C1C[C@H](CC(=O)N2CCC(N3CCCCC3)CC2)C(=O)NC[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)N1 10.1016/s0960-894x(01)00841-1
11251301 143053 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 6 6 2.0 NC1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
CHEMBL389432 143053 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cellsDisplacement of [125I]neurokinin A from human NK2 receptor expressed in CHOK1 cells
ChEMBL 663 7 6 6 2.0 NC1CCN([C@@H]2CC(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@H](Cc3ccccc3)CNC2=O)CC1 10.1021/jm040832y
44343033 9812 None 0 Human Binding pKi = 8.3 8.3 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 685 9 4 5 5.4 O=C(N[C@H]1CCCCN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)OCc1ccccc1 10.1021/jm011127h
CHEMBL113765 9812 None 0 Human Binding pKi = 8.3 8.3 - 1
Inhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experimentsInhibitory affinity constant (pKi) against tachykinin receptor 2 (NK-2R) using heterologous competition experiments
ChEMBL 685 9 4 5 5.4 O=C(N[C@H]1CCCCN(Cc2ccccc2)C(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC1=O)OCc1ccccc1 10.1021/jm011127h
44315422 103194 None 0 Human Binding pKi = 8.3 8.3 -2 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
CHEMBL307877 103194 None 0 Human Binding pKi = 8.3 8.3 -2 3
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]-NKA as radioligand
ChEMBL 747 13 1 8 7.5 CCN(C/C(=N\OC)[C@H](CCN1CCC(n2c(=O)n(CC(=O)O)c3ccccc32)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00462-6
9940831 14652 None 0 Rabbit Binding pKi = 8.3 8.3 -1 4
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1205204 14652 None 0 Rabbit Binding pKi = 8.3 8.3 -1 4
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL65468 14652 None 0 Rabbit Binding pKi = 8.3 8.3 -1 4
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 810 13 4 9 5.7 O=C(OCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
44380248 58180 None 0 Human Binding pKi = 8.3 8.3 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168144 58180 None 0 Human Binding pKi = 8.3 8.3 -1 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 13 0 7 7.3 CN(C/C(=N\OCCn1ccnc1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
10303126 153273 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 560 11 3 6 3.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC=CC1)c1cc2ccccc2s1 10.1021/jm070289w
CHEMBL397702 153273 None 0 Human Binding pKi = 8.3 8.3 - 1
Displacement of [125I]neurokinin A from human recombinant NK2 receptorDisplacement of [125I]neurokinin A from human recombinant NK2 receptor
ChEMBL 560 11 3 6 3.3 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCOCC2)CC=CC1)c1cc2ccccc2s1 10.1021/jm070289w
44305818 14801 None 0 Rabbit Binding pKi = 8.3 8.3 -1 4
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL1206764 14801 None 0 Rabbit Binding pKi = 8.3 8.3 -1 4
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
CHEMBL305119 14801 None 0 Rabbit Binding pKi = 8.3 8.3 -1 4
Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.Binding affinity for NK-2 receptor was determined in vitro using isolated rabbit pulmonary artery.
ChEMBL 698 13 3 8 4.3 CN(Cc1ccccc1)C(=O)[C@H](Cc1ccc2ccccc2c1)NC(=O)[C@H]1C[C@H](O)CN1C(=O)c1cn(CCCCc2nnn[nH]2)c2ccccc12 10.1016/S0960-894X(96)00604-X
10696939 181704 None 0 Human Binding pKi = 8.2 8.2 -3 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 506 8 1 4 6.3 CC[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL47713 181704 None 0 Human Binding pKi = 8.2 8.2 -3 3
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 506 8 1 4 6.3 CC[C@H](NC(=O)c1c(CN2CCN(C(C)C)CC2)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
118724122 116475 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1296 40 16 22 -3.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)Nc1ccc([N+](=O)[O-])c2nonc12)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm401823z
CHEMBL3360201 116475 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cellsDisplacement of [3H]GR100679 from NK2 receptor (unknown origin) expressed in CHO/T cells
ChEMBL 1296 40 16 22 -3.0 CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1cnc[nH]1)Nc1ccc([N+](=O)[O-])c2nonc12)[C@@H](C)O)C(C)C)C(N)=O 10.1021/jm401823z
44380081 58125 None 0 Human Binding pKi = 7.3 7.3 -100 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL167546 58125 None 0 Human Binding pKi = 7.3 7.3 -100 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 738 13 1 7 6.3 CN(C/C(=N\OCCN1CCNCC1)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
44380733 58633 None 0 Human Binding pKi = 7.3 7.3 -7 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168437 58633 None 0 Human Binding pKi = 7.3 7.3 -7 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 720 14 1 6 8.7 COCCO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44390607 63925 None 0 Human Binding pKi = 7.3 7.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
CHEMBL180539 63925 None 0 Human Binding pKi = 7.3 7.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 558 11 3 5 5.3 CC(C)(C)c1ccc(Oc2ccc(NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCCCN3CCOCC3)cc2)cc1 10.1016/j.bmcl.2004.11.045
44384147 130761 None 0 Rat Binding pKi = 7.3 7.3 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 524 9 1 3 6.3 CN(CC(CCN1CCC(CO)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
CHEMBL368372 130761 None 0 Rat Binding pKi = 7.3 7.3 - 1
Inhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranesInhibition of [125I]NKA binding to neurokinin NK2 receptor from rat duodenum membranes
ChEMBL 524 9 1 3 6.3 CN(CC(CCN1CCC(CO)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccccc1 10.1016/S0960-894X(00)80694-0
44434188 89640 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 574 11 3 5 5.1 CN1CCCC1CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL237517 89640 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 574 11 3 5 5.1 CN1CCCC1CCCNC(=O)C(Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44434161 90295 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
CHEMBL238392 90295 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 562 11 4 5 4.1 CC(C)C[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1)C(N)=O 10.1016/j.bmcl.2007.06.053
44434170 154519 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 566 15 4 7 2.8 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL398982 154519 None 0 Human Binding pKi = 7.3 7.3 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 566 15 4 7 2.8 NCCOCCOCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCC1 10.1016/j.bmcl.2007.06.053
44390506 63524 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 552 12 3 5 4.1 O=C(Nc1ccc(OCc2cc(F)cc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL179986 63524 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 552 12 3 5 4.1 O=C(Nc1ccc(OCc2cc(F)cc(F)c2)cc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391084 64348 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181153 64348 None 0 Human Binding pKi = 6.3 6.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccc(Oc2ccccc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391034 64594 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL181581 64594 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 529 12 2 5 4.1 CC(C)(Oc1ccccc1-c1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44390534 64873 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL182082 64873 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 584 12 3 5 4.9 O=C(Nc1ccc(OCc2ccc(C(F)(F)F)cc2)cc1)N[C@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44391022 122090 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccccc1Oc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
CHEMBL359487 122090 None 0 Human Binding pKi = 5.3 5.3 - 1
Binding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligandBinding affinity for human tachykinin receptor 2 was measured by using [125I]NKA as radio ligand
ChEMBL 502 11 3 5 4.1 O=C(Nc1ccccc1Oc1ccccc1)N[C@@H](Cc1ccccc1)C(=O)NCCCN1CCOCC1 10.1016/j.bmcl.2004.11.045
44331207 168078 None 0 Human Binding pKi = 6.3 6.3 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 579 12 3 6 3.8 O=C(NCCc1c[nH]c2ccccc12)c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
CHEMBL431838 168078 None 0 Human Binding pKi = 6.3 6.3 - 1
Compound was tested for it's binding affinity against human Tachykinin receptor 2Compound was tested for it's binding affinity against human Tachykinin receptor 2
ChEMBL 579 12 3 6 3.8 O=C(NCCc1c[nH]c2ccccc12)c1nccnc1C(=O)N(CCCN1CCOCC1)CCc1c[nH]c2ccccc12 10.1016/s0960-894x(02)00539-5
44312406 157435 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 702 13 0 8 7.2 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1(=O)=O)c1ccccc1 10.1016/s0960-894x(02)00471-7
CHEMBL407769 157435 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 702 13 0 8 7.2 O=C(C1=C(c2ccccc2)OC2OC(COCc3ccccc3)C(OCc3ccccc3)C(OCc3ccccc3)C2S1(=O)=O)c1ccccc1 10.1016/s0960-894x(02)00471-7
10717843 101158 None 0 Human Binding pKi = 7.3 7.3 -15 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 437 7 1 3 6.1 CC(C)[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
CHEMBL295059 101158 None 0 Human Binding pKi = 7.3 7.3 -15 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 437 7 1 3 6.1 CC(C)[C@H](NC(=O)c1c(CN(C)C)c(-c2ccccc2)nc2ccccc12)c1ccccc1 10.1021/jm000501v
25222441 199597 None 0 Human Binding pKi = 6.3 6.3 -104 4
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
CHEMBL567849 199597 None 0 Human Binding pKi = 6.3 6.3 -104 4
Displacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cellsDisplacement of [3H]SR48968 from human recombinant NK2 receptor expressed in HEK293 cells
ChEMBL 589 8 0 3 6.4 CC(=O)N(C)C1CCN(CCC(C)(C(=O)N(C)Cc2ccc(F)c(C(F)(F)F)c2)c2ccc(Cl)c(Cl)c2)CC1 10.1021/jm900948q
44314872 96925 None 0 Human Binding pKi = 7.3 7.3 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL265499 96925 None 0 Human Binding pKi = 7.3 7.3 -1 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 740 13 1 7 6.7 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
44329351 210577 None 0 Golden hamster Binding pKi = 6.3 6.3 13 2
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL97958 210577 None 0 Golden hamster Binding pKi = 6.3 6.3 13 2
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 358 4 2 6 3.1 CCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
148124 209557 None 54 Human Binding pKi = 6.3 6.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL3545252 209557 None 54 Human Binding pKi = 6.3 6.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
CHEMBL92 209557 None 54 Human Binding pKi = 6.3 6.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 807 8 5 14 3.3 CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@@H]12)C3(C)C nan
44363979 121047 None 0 Human Binding pKi = 7.3 7.3 -2 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL356268 121047 None 0 Human Binding pKi = 7.3 7.3 -2 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 711 13 1 6 8.3 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(CN2CCCCC2CO)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
138106918 197942 None 30 Human Binding pKi = 6.3 6.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
5311497 197942 None 30 Human Binding pKi = 6.3 6.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
CHEMBL553025 197942 None 30 Human Binding pKi = 6.3 6.3 - 1
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 778 7 2 11 4.8 CCC1=C[C@@H]2CN(C1)Cc1c([nH]c3ccccc13)[C@@](C(=O)OC)(c1cc3c(cc1OC)N(C)[C@H]1[C@@](O)(C(=O)OC)[C@H](OC(C)=O)[C@]4(CC)C=CCN5CC[C@]31[C@@H]54)C2 nan
6918276 15618 None 4 Human Binding pKi = 6.3 6.3 -56 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
CHEMBL1221512 15618 None 4 Human Binding pKi = 6.3 6.3 -56 8
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 559 18 4 9 1.7 CC[C@H](C)[C@@H](CO[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCS(C)(=O)=O)C(=O)OC(C)C)NC[C@@H](N)CS nan
44281788 100040 None 0 Human Binding pKi = 7.3 7.3 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286640 100040 None 0 Human Binding pKi = 7.3 7.3 -1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 583 11 2 6 5.9 CO/N=C(\CNC(=O)c1ccccc1OC)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10044833 107503 None 0 Golden hamster Binding pKi = 7.3 7.3 43 2
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318254 107503 None 0 Golden hamster Binding pKi = 7.3 7.3 43 2
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 372 5 2 6 3.5 CCCc1nc2[nH]c(N3CCOCC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44329517 210736 None 0 Human Binding pKi = 6.3 6.3 -36 2
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
CHEMBL98929 210736 None 0 Human Binding pKi = 6.3 6.3 -36 2
Inhibition constant for displacement of [3H]NKA from the cloned human NK2 receptorInhibition constant for displacement of [3H]NKA from the cloned human NK2 receptor
ChEMBL 387 4 1 6 3.1 CC(C)N1Cc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2C1=O 10.1016/0960-894X(95)00502-K
44329149 107612 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 392 6 3 5 5.4 CC(C)c1nc2[nH]c(NCc3ccccc3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL318880 107612 None 0 Human Binding pKi = 5.3 5.3 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 392 6 3 5 5.4 CC(C)c1nc2[nH]c(NCc3ccccc3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
11057 176253 None 16 Human Binding pKi = 6.3 6.3 -1 20
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
3468 176253 None 16 Human Binding pKi = 6.3 6.3 -1 20
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL459265 176253 None 16 Human Binding pKi = 6.3 6.3 -1 20
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
CHEMBL64894 176253 None 16 Human Binding pKi = 6.3 6.3 -1 20
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 372 4 0 2 4.5 CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1 nan
44314454 105673 None 0 Human Binding pKi = 6.3 6.3 -4 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
CHEMBL312295 105673 None 0 Human Binding pKi = 6.3 6.3 -4 2
Inhibitory activity against human tachykinin receptor 2Inhibitory activity against human tachykinin receptor 2
ChEMBL 758 12 0 6 7.9 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCN(CC(=O)N2CCc3ccccc3C2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00464-9
3823 50235 None 31 Human Binding pKi = 5.2 5.2 -36 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
76973198 50235 None 31 Human Binding pKi = 5.2 5.2 -36 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
CHEMBL157101 50235 None 31 Human Binding pKi = 5.2 5.2 -36 11
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 530 7 0 7 4.2 CC(=O)N1CCN(c2ccc(OCC3COC(Cn4ccnc4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1 nan
44380094 58761 None 0 Human Binding pKi = 7.2 7.2 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL168584 58761 None 0 Human Binding pKi = 7.2 7.2 -3 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 719 13 2 6 7.6 NC(=O)CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(02)00027-6
44363984 35677 None 0 Human Binding pKi = 7.2 7.2 -4 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
CHEMBL144011 35677 None 0 Human Binding pKi = 7.2 7.2 -4 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 735 14 0 5 9.3 C=CCC1CCCN(CC2CCN(CCC(/C(COCc3cc(C(F)(F)F)cc(C(F)(F)F)c3)=N/OC)c3ccc(Cl)c(Cl)c3)CC2)C1=O 10.1016/s0960-894x(00)00702-2
15730 71142 None 57 Human Binding pKi = 5.2 5.2 -2 10
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
CHEMBL195437 71142 None 57 Human Binding pKi = 5.2 5.2 -2 10
DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)DRUGMATRIX: Tachykinin NK2 radioligand binding (ligand: [3H] SR-48968)
ChEMBL 206 7 1 1 4.3 CCCCCCCCc1ccc(O)cc1 nan
44329367 210707 None 0 Golden hamster Binding pKi = 4.2 4.2 - 1
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 425 5 2 6 4.0 CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
CHEMBL98760 210707 None 0 Golden hamster Binding pKi = 4.2 4.2 - 1
Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)Inhibition constant for displacement of [3H]NKA from Tachykinin receptor 2 found in hamster urinary bladder membrane (HUBM)
ChEMBL 425 5 2 6 4.0 CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(N3CCOCC3)nc2c1 10.1016/0960-894X(95)00502-K
44329531 210546 None 0 Human Binding pKi = 5.2 5.2 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 384 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCC(=O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
CHEMBL97764 210546 None 0 Human Binding pKi = 5.2 5.2 - 1
Displacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cellsDisplacement of [3H]NKA from the cloned human Tachykinin receptor 2 which has been expressed in baculovirus infected insect sf21 cells
ChEMBL 384 4 2 6 4.0 CC(C)c1nc2[nH]c(N3CCC(=O)CC3)nc(Nc3ccc(Cl)cc3)c-2n1 10.1016/0960-894X(95)00502-K
44364003 119059 None 0 Human Binding pKi = 7.2 7.2 -9 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
CHEMBL342572 119059 None 0 Human Binding pKi = 7.2 7.2 -9 2
Binding affinity towards NK2 receptorBinding affinity towards NK2 receptor
ChEMBL 681 11 0 5 8.1 CO/N=C(\COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C(CCN1CCC(C(=O)N2CCCC2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(00)00702-2
44380080 12246 None 0 Human Binding pKi = 6.2 6.2 -323 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL1184507 12246 None 0 Human Binding pKi = 6.2 6.2 -323 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
CHEMBL352842 12246 None 0 Human Binding pKi = 6.2 6.2 -323 2
Binding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligandBinding affinity against recombinant human tachykinin receptor 2 in CHO cells using [3H]NKA as a radioligand
ChEMBL 726 14 0 5 7.5 CN(C/C(=N\OCCC[N+](C)(C)C)C(CCN1CCC(N2CCCCC2=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1 10.1016/s0960-894x(02)00027-6
71549913 118920 None 0 Human Binding pKi = 5.2 5.2 -588 3
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
CHEMBL3422007 118920 None 0 Human Binding pKi = 5.2 5.2 -588 3
Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).Binding Assay: The affinity of compounds of the invention for the NK2 receptor was evaluated in CHO recombinant cells which express the human NK2 receptor. Membrane suspensions were prepared from these cells. The following radioligand [125I]-Neurokinin A (PerkinElmer Cat#NEX252) was used in this assay. Binding assays were performed in a 25 mM HEPES/1 mM CaCl2/5 mM MgCl2/0.5% BSA/10 μg/ml saponin, at pH 7.4. Binding assays consisted of 25 μl of membrane suspension (approximately 3.75 μg of protein/well in a 96 well plate), 50 μl of compound or reference ligand (Neurokinin A) at increasing concentrations (diluted in assay buffer) and 0.1 nM [125I]-Neurokinin A. The plate was incubated 60 min at 25° C. in a water bath and then filtered over GF/C filters (Perkin Elmer, 6005174, presoaked in assay buffer without saponine for 2 h at room temperature) with a Filtration unit (Perkin Elmer). The radioactivity retained on the filters was measured by using the TopCount-NXT reader (Packard).
ChEMBL 415 3 0 6 4.6 Cc1cccc(-c2nnc3n2CCN(C(=O)c2ccc(-c4cccs4)cc2)[C@@H]3C)n1 nan
44281633 100041 None 0 Human Binding pKi = 8.2 8.2 -3 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL286646 100041 None 0 Human Binding pKi = 8.2 8.2 -3 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 664 11 1 7 7.7 CO/N=C(\CN(C)C(=O)c1cc(C)nc(-c2cccs2)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281778 109752 None 0 Human Binding pKi = 8.2 8.2 4 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL32279 109752 None 0 Human Binding pKi = 8.2 8.2 4 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 608 11 1 5 8.0 CO/N=C(\COCc1cc(Cl)cc(Cl)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
44281672 113588 None 0 Human Binding pKi = 8.2 8.2 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
CHEMBL33215 113588 None 0 Human Binding pKi = 8.2 8.2 1 2
Binding affinity test against Neurokinin 2 (NK2) receptorBinding affinity test against Neurokinin 2 (NK2) receptor
ChEMBL 596 10 1 6 6.2 CO/N=C(\CN(C)C(=O)c1cc(C)nc(C)c1)C(CCN1CCC(O)(c2ccccc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/s0960-894x(01)00709-0
10718673 179213 None 0 Human Binding pKi = 8.2 8.2 -1 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 457 6 1 4 5.4 C[C@H](NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
CHEMBL47179 179213 None 0 Human Binding pKi = 8.2 8.2 -1 2
Displacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranesDisplacement of [125 I]-NKA binding to tachykinin receptor 2 in CHO membranes
ChEMBL 457 6 1 4 5.4 C[C@H](NC(=O)c1c(CN2CCOCC2)c(-c2ccccc2)nc2ccccc12)C1CCCCC1 10.1021/jm000501v
10321179 15573 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 443 5 1 3 4.6 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1F 10.1021/jm00019a006
CHEMBL122019 15573 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 443 5 1 3 4.6 O=C1OC2(CCN(CCc3c[nH]c4ccc(F)cc34)CC2)CN1Cc1ccc(F)cc1F 10.1021/jm00019a006
10091869 112893 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 391 5 1 2 4.8 Fc1ccc2[nH]cc(CCN3CCC4(CC3)CCN(Cc3ccccc3)C4)c2c1 10.1021/jm00019a006
CHEMBL330766 112893 None 0 Rat Binding pKi = 8.2 8.2 - 1
Binding affinity against tachykinin receptor 2 from rat colon.Binding affinity against tachykinin receptor 2 from rat colon.
ChEMBL 391 5 1 2 4.8 Fc1ccc2[nH]cc(CCN3CCC4(CC3)CCN(Cc3ccccc3)C4)c2c1 10.1021/jm00019a006
44434196 149312 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
CHEMBL394418 149312 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 594 11 3 5 4.8 O=C(NC1(C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCN2CCCC2)CCc2ccccc21)c1cc2ccccc2s1 10.1016/j.bmcl.2007.06.053
44434180 153125 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
CHEMBL397576 153125 None 0 Human Binding pKi = 8.2 8.2 - 1
Displacement of [125I]NKA from human NK2 expressed in CHO-K1 cellsDisplacement of [125I]NKA from human NK2 expressed in CHO-K1 cells
ChEMBL 618 17 3 5 6.5 CCCCN(CCCC)CCCNC(=O)[C@H](Cc1ccccc1)NC(=O)C1(NC(=O)c2cc3ccccc3s2)CCCCC1 10.1016/j.bmcl.2007.06.053
44374557 119659 None 0 Human Binding pKi = 8.2 8.2 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
CHEMBL346285 119659 None 0 Human Binding pKi = 8.2 8.2 -1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 693 11 6 6 1.9 CN(C)CCNC(=O)C[C@@H]1CC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H](Cc2ccccc2)CNC1=O 10.1016/s0960-894x(01)00841-1
44374622 120127 None 0 Human Binding pKi = 8.2 8.2 1 2
Displacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cellsDisplacement of [125I]NKA from human Tachykinin receptor 2 expressed in CHO cells
ChEMBL 825 11 10 10 -0.8