Ligand source activities (1 row/activity)
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 1499 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| 3779 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| 3779.0 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| 536 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| CHEMBL434 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| DB01064 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.3 | 8.3 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
ChEMBL | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | nan | ||
| 1193 | 1656 | None | 64 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 11 | calcium imaging in ransfected human embryonic kidney (HEK)-293Tcalcium imaging in ransfected human embryonic kidney (HEK)-293T |
Drug Central | 281 | 3 | 2 | 2 | 4.1 | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F | None | ||
| 2447 | 1656 | None | 64 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 11 | calcium imaging in ransfected human embryonic kidney (HEK)-293Tcalcium imaging in ransfected human embryonic kidney (HEK)-293T |
Drug Central | 281 | 3 | 2 | 2 | 4.1 | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F | None | ||
| 3371 | 1656 | None | 64 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 11 | calcium imaging in ransfected human embryonic kidney (HEK)-293Tcalcium imaging in ransfected human embryonic kidney (HEK)-293T |
Drug Central | 281 | 3 | 2 | 2 | 4.1 | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F | None | ||
| CHEMBL23588 | 1656 | None | 64 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 11 | calcium imaging in ransfected human embryonic kidney (HEK)-293Tcalcium imaging in ransfected human embryonic kidney (HEK)-293T |
Drug Central | 281 | 3 | 2 | 2 | 4.1 | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F | None | ||
| DB02266 | 1656 | None | 64 | Human | Functional | pEC50 | = | 8.2 | 8.2 | -1 | 11 | calcium imaging in ransfected human embryonic kidney (HEK)-293Tcalcium imaging in ransfected human embryonic kidney (HEK)-293T |
Drug Central | 281 | 3 | 2 | 2 | 4.1 | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F | None | ||
| 1499 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
| 3779 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
| 3779.0 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
| 536 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
| CHEMBL434 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
| DB01064 | 2091 | None | 34 | Human | Functional | pEC50 | = | 8.1 | 8.1 | -63 | 38 | Agonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assayAgonist activity at human TAS2R14 expressed in HEK293T cells co-expressing Galpha15 assessed as increase in intracellular calcium level by Calcium-3 dye based fluorescence assay |
Drug Central | 211 | 4 | 4 | 4 | 1.1 | CC(NCC(c1ccc(c(c1)O)O)O)C | None | ||
| 1183 | 3971 | None | 0 | Human | Functional | pEC50 | = | 3.2 | 3.2 | -1 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | 152 | 2 | 1 | 3 | 1.2 | COc1cc(C=O)ccc1O | 34307435 | ||
| 6412 | 3971 | None | 0 | Human | Functional | pEC50 | = | 3.2 | 3.2 | -1 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | 152 | 2 | 1 | 3 | 1.2 | COc1cc(C=O)ccc1O | 34307435 | ||
| CHEMBL13883 | 3971 | None | 0 | Human | Functional | pEC50 | = | 3.2 | 3.2 | -1 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | 152 | 2 | 1 | 3 | 1.2 | COc1cc(C=O)ccc1O | 34307435 | ||
| 12437 | 1171 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 268 | 0 | 2 | 5 | 3.1 | C1=CC2=C(C=C1O)OC3=C2C(=O)OC4=C3C=CC(=C4)O | 21942422 | ||
| 5281707 | 1171 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 268 | 0 | 2 | 5 | 3.1 | C1=CC2=C(C=C1O)OC3=C2C(=O)OC4=C3C=CC(=C4)O | 21942422 | ||
| CHEMBL30707 | 1171 | None | 0 | Human | Functional | pEC50 | = | 3.5 | 3.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 268 | 0 | 2 | 5 | 3.1 | C1=CC2=C(C=C1O)OC3=C2C(=O)OC4=C3C=CC(=C4)O | 21942422 | ||
| 2826 | 1784 | None | 76 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -64 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | 270 | 1 | 3 | 5 | 2.6 | Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O | 30009876 | ||
| 5280961 | 1784 | None | 76 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -64 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | 270 | 1 | 3 | 5 | 2.6 | Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O | 30009876 | ||
| CHEMBL44 | 1784 | None | 76 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -64 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | 270 | 1 | 3 | 5 | 2.6 | Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O | 30009876 | ||
| DB01645 | 1784 | None | 76 | Human | Functional | pEC50 | = | 4.2 | 4.2 | -64 | 7 | UnclassifiedUnclassified |
Guide to Pharmacology | 270 | 1 | 3 | 5 | 2.6 | Oc1ccc(cc1)c1coc2c(c1=O)c(O)cc(c2)O | 30009876 | ||
| 12444 | 1940 | None | 0 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 302 | 2 | 3 | 6 | 2.5 | COC1=C(C=CC(=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O | 24117141 | ||
| 3512637 | 1940 | None | 0 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 302 | 2 | 3 | 6 | 2.5 | COC1=C(C=CC(=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O | 24117141 | ||
| CHEMBL398282 | 1940 | None | 0 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 302 | 2 | 3 | 6 | 2.5 | COC1=C(C=CC(=C1)C2CC(=O)C3=C(C=C(C=C3O2)O)O)O | 24117141 | ||
| 11095 | 1583 | None | 0 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 288 | 1 | 4 | 6 | 2.2 | C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(C=C3)O)O | 24117141 | ||
| 12442 | 1583 | None | 0 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 288 | 1 | 4 | 6 | 2.2 | C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(C=C3)O)O | 24117141 | ||
| CHEMBL307893 | 1583 | None | 0 | Human | Functional | pEC50 | = | 4.2 | 4.2 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 288 | 1 | 4 | 6 | 2.2 | C1C(OC2=CC(=CC(=C2C1=O)O)O)C3=CC(=C(C=C3)O)O | 24117141 | ||
| 12449 | 3606 | None | 50 | Human | Functional | pEC50 | = | 4.3 | 4.3 | -22 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 482 | 4 | 5 | 10 | 2.4 | COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O | 24117141 | ||
| 31553 | 3606 | None | 50 | Human | Functional | pEC50 | = | 4.3 | 4.3 | -22 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 482 | 4 | 5 | 10 | 2.4 | COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O | 24117141 | ||
| CHEMBL431701 | 3606 | None | 50 | Human | Functional | pEC50 | = | 4.3 | 4.3 | -22 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 482 | 4 | 5 | 10 | 2.4 | COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O | 24117141 | ||
| DB09298 | 3606 | None | 50 | Human | Functional | pEC50 | = | 4.3 | 4.3 | -22 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 482 | 4 | 5 | 10 | 2.4 | COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O | 24117141 | ||
| 12441 | 3140 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | 1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 242 | 1 | 2 | 3 | 2.8 | C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O | 21942422 | ||
| 382975 | 3140 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | 1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 242 | 1 | 2 | 3 | 2.8 | C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O | 21942422 | ||
| CHEMBL1957037 | 3140 | None | 0 | Human | Functional | pEC50 | = | 4.3 | 4.3 | 1 | 2 | UnclassifiedUnclassified |
Guide to Pharmacology | 242 | 1 | 2 | 3 | 2.8 | C1C(COC2=C1C=CC(=C2)O)C3=CC=C(C=C3)O | 21942422 | ||
| 12443 | 1584 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 288 | 3 | 5 | 6 | 2.1 | C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2O)O)O)O)O | 24117141 | ||
| 5461154 | 1584 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 288 | 3 | 5 | 6 | 2.1 | C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2O)O)O)O)O | 24117141 | ||
| CHEMBL127409 | 1584 | None | 0 | Human | Functional | pEC50 | = | 4.4 | 4.4 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 288 | 3 | 5 | 6 | 2.1 | C1=CC(=C(C=C1/C=C/C(=O)C2=C(C=C(C=C2O)O)O)O)O | 24117141 | ||
| 12450 | 3859 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 302 | 11 | 0 | 6 | 2.4 | CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC | 24285091 | ||
| 6050 | 3859 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 302 | 11 | 0 | 6 | 2.4 | CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC | 24285091 | ||
| CHEMBL118722 | 3859 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 302 | 11 | 0 | 6 | 2.4 | CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC | 24285091 | ||
| DB12709 | 3859 | None | 0 | Human | Functional | pEC50 | = | 4.5 | 4.5 | - | 1 | UnclassifiedUnclassified |
Guide to Pharmacology | 302 | 11 | 0 | 6 | 2.4 | CCCC(=O)OCC(COC(=O)CCC)OC(=O)CCC | 24285091 | ||
| 4285 | 3110 | None | 68 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -2 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | 274 | 4 | 4 | 5 | 2.3 | Oc1ccc(cc1)CCC(=O)c1c(O)cc(cc1O)O | 24117141 | ||
| 4788 | 3110 | None | 68 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -2 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | 274 | 4 | 4 | 5 | 2.3 | Oc1ccc(cc1)CCC(=O)c1c(O)cc(cc1O)O | 24117141 | ||
| CHEMBL45068 | 3110 | None | 68 | Human | Functional | pEC50 | = | 4.5 | 4.5 | -2 | 3 | UnclassifiedUnclassified |
Guide to Pharmacology | 274 | 4 | 4 | 5 | 2.3 | Oc1ccc(cc1)CCC(=O)c1c(O)cc(cc1O)O | 24117141 | ||
Showing 1 to 50 of 102 entries
| Ligands (move mouse cursor over ligand name to see structure) | Receptor | Activity | Chemical information | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
Ligands (move mouse cursor over ligand name to see structure)
| Receptor
| Activity
| Chemical information
| |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sel. page | Common name
| GPCRdb ID
| Reference ligand
| Vendors | Species
| Assay Type
| Activity Type
| Activity Relation
| Activity Value | p-value (-log) | Fold selectivity | Tested GPCRs | Assay Description
| Source
| Mol weight | Rot Bonds | H don | H acc | LogP | Smiles
| DOI
| |
| 168355623 | 193952 | None | 3 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Partial agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayPartial agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 373 | 3 | 2 | 4 | 4.6 | FC(F)(F)c1cc(Nc2ccccc2-c2nnn[nH]2)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5275180 | 193952 | None | 3 | Human | Binding | pEC50 | = | 7 | 7.0 | - | 0 | Partial agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayPartial agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 373 | 3 | 2 | 4 | 4.6 | FC(F)(F)c1cc(Nc2ccccc2-c2nnn[nH]2)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171349560 | 193573 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 307 | 3 | 2 | 6 | 2.4 | FC(F)(F)c1nccc(Nc2ccccc2-c2nnn[nH]2)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5265924 | 193573 | None | 0 | Human | Binding | pEC50 | = | 6.0 | 6.0 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 307 | 3 | 2 | 6 | 2.4 | FC(F)(F)c1nccc(Nc2ccccc2-c2nnn[nH]2)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171343423 | 193675 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1ccccc1Nc1cncc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5268477 | 193675 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 282 | 3 | 2 | 3 | 3.5 | O=C(O)c1ccccc1Nc1cncc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171353074 | 194176 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 331 | 3 | 2 | 6 | 2.4 | C#Cc1cc(C(F)(F)F)nc(Nc2ccccc2-c2nnn[nH]2)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5280454 | 194176 | None | 0 | Human | Binding | pEC50 | = | 5.9 | 5.9 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 331 | 3 | 2 | 6 | 2.4 | C#Cc1cc(C(F)(F)F)nc(Nc2ccccc2-c2nnn[nH]2)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171352812 | 193896 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 2 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 305 | 3 | 2 | 2 | 4.1 | C#Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5273955 | 193896 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 2 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 305 | 3 | 2 | 2 | 4.1 | C#Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171356743 | 193915 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 307 | 3 | 2 | 6 | 2.4 | FC(F)(F)c1ccnc(Nc2ccccc2-c2nnn[nH]2)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5274304 | 193915 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 307 | 3 | 2 | 6 | 2.4 | FC(F)(F)c1ccnc(Nc2ccccc2-c2nnn[nH]2)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171355069 | 193942 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 283 | 3 | 2 | 4 | 2.9 | O=C(O)c1ccccc1Nc1nccc(C(F)(F)F)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5274977 | 193942 | None | 0 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 283 | 3 | 2 | 4 | 2.9 | O=C(O)c1ccccc1Nc1nccc(C(F)(F)F)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171355938 | 194048 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 3 | 4.0 | N#Cc1ccc(Nc2ccccc2C(=O)O)cc1C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5277615 | 194048 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 3 | 4.0 | N#Cc1ccc(Nc2ccccc2C(=O)O)cc1C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
| 171355292 | 194183 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 3 | 4.0 | N#Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5280542 | 194183 | None | 0 | Human | Binding | pEC50 | = | 6.8 | 6.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 3 | 4.0 | N#Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 20043403 | 194399 | None | 3 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 295 | 3 | 2 | 2 | 4.5 | Cc1c(Nc2ccccc2C(=O)O)cccc1C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5285283 | 194399 | None | 3 | Human | Binding | pEC50 | = | 5.8 | 5.8 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 295 | 3 | 2 | 2 | 4.5 | Cc1c(Nc2ccccc2C(=O)O)cccc1C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
| 122192740 | 123881 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 339 | 4 | 2 | 2 | 5.8 | O=C(O)c1ccccc1Nc1cccc(S(F)(F)(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL3623735 | 123881 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 339 | 4 | 2 | 2 | 5.8 | O=C(O)c1ccccc1Nc1cccc(S(F)(F)(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 153078878 | 194133 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 295 | 3 | 2 | 2 | 4.5 | Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5279381 | 194133 | None | 0 | Human | Binding | pEC50 | = | 6.7 | 6.7 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 295 | 3 | 2 | 2 | 4.5 | Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 45117731 | 194554 | None | 2 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 359 | 3 | 2 | 2 | 4.9 | O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1Br | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5288875 | 194554 | None | 2 | Human | Binding | pEC50 | = | 5.7 | 5.7 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 359 | 3 | 2 | 2 | 4.9 | O=C(O)c1ccccc1Nc1cccc(C(F)(F)F)c1Br | 10.1021/acs.jmedchem.2c01997 | ||
| 72736882 | 103810 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 359 | 3 | 2 | 2 | 4.9 | O=C(O)c1ccccc1Nc1cc(Br)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL3088246 | 103810 | None | 0 | Human | Binding | pEC50 | = | 6.6 | 6.6 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 359 | 3 | 2 | 2 | 4.9 | O=C(O)c1ccccc1Nc1cc(Br)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171352961 | 194038 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 332 | 3 | 2 | 7 | 2.3 | N#Cc1cc(C(F)(F)F)nc(Nc2ccccc2-c2nnn[nH]2)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5277281 | 194038 | None | 0 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 332 | 3 | 2 | 7 | 2.3 | N#Cc1cc(C(F)(F)F)nc(Nc2ccccc2-c2nnn[nH]2)n1 | 10.1021/acs.jmedchem.2c01997 | ||
| 64855143 | 194107 | None | 1 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 359 | 3 | 2 | 2 | 4.9 | O=C(O)c1ccccc1Nc1ccc(Br)c(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5278834 | 194107 | None | 1 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 359 | 3 | 2 | 2 | 4.9 | O=C(O)c1ccccc1Nc1ccc(Br)c(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 63538677 | 194076 | None | 1 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 295 | 3 | 2 | 2 | 4.5 | Cc1ccc(Nc2ccccc2C(=O)O)cc1C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5278171 | 194076 | None | 1 | Human | Binding | pEC50 | = | 6.5 | 6.5 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 295 | 3 | 2 | 2 | 4.5 | Cc1ccc(Nc2ccccc2C(=O)O)cc1C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
| 171351286 | 193568 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 5 | 3.0 | FC(F)(F)c1cc(Nc2ccccc2-c2nnn[nH]2)ccn1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5265867 | 193568 | None | 0 | Human | Binding | pEC50 | = | 5.5 | 5.5 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 5 | 3.0 | FC(F)(F)c1cc(Nc2ccccc2-c2nnn[nH]2)ccn1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171352197 | 193926 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 5 | 3.0 | FC(F)(F)c1ccnc(Nc2ccccc2-c2nnn[nH]2)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5274470 | 193926 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 5 | 3.0 | FC(F)(F)c1ccnc(Nc2ccccc2-c2nnn[nH]2)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 171357797 | 194091 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 319 | 3 | 2 | 2 | 4.5 | CC#Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5278477 | 194091 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 319 | 3 | 2 | 2 | 4.5 | CC#Cc1cc(Nc2ccccc2C(=O)O)cc(C(F)(F)F)c1 | 10.1021/acs.jmedchem.2c01997 | ||
| 66477371 | 193944 | None | 1 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 295 | 3 | 2 | 2 | 4.5 | Cc1ccc(C(F)(F)F)cc1Nc1ccccc1C(=O)O | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5275001 | 193944 | None | 1 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 295 | 3 | 2 | 2 | 4.5 | Cc1ccc(C(F)(F)F)cc1Nc1ccccc1C(=O)O | 10.1021/acs.jmedchem.2c01997 | ||
| 12429 | 3453 | None | 9 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | Agonist activity at TAS2R14 (unknown origin) by stably expressed cell-based assayAgonist activity at TAS2R14 (unknown origin) by stably expressed cell-based assay |
ChEMBL | 381 | 5 | 1 | 7 | 2.2 | CC1=NOC(C)=C1CN2C=C(C=N2)N3C(=O)CN(CC4=CC=CC(O)=C4)C3=O | 10.1021/acs.jmedchem.0c00388 | ||
| 57422431 | 3453 | None | 9 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | Agonist activity at TAS2R14 (unknown origin) by stably expressed cell-based assayAgonist activity at TAS2R14 (unknown origin) by stably expressed cell-based assay |
ChEMBL | 381 | 5 | 1 | 7 | 2.2 | CC1=NOC(C)=C1CN2C=C(C=N2)N3C(=O)CN(CC4=CC=CC(O)=C4)C3=O | 10.1021/acs.jmedchem.0c00388 | ||
| CHEMBL3924866 | 3453 | None | 9 | Human | Binding | pEC50 | = | 4.4 | 4.4 | - | 0 | Agonist activity at TAS2R14 (unknown origin) by stably expressed cell-based assayAgonist activity at TAS2R14 (unknown origin) by stably expressed cell-based assay |
ChEMBL | 381 | 5 | 1 | 7 | 2.2 | CC1=NOC(C)=C1CN2C=C(C=N2)N3C(=O)CN(CC4=CC=CC(O)=C4)C3=O | 10.1021/acs.jmedchem.0c00388 | ||
| 171351277 | 194578 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 3 | 4.0 | N#Cc1ccc(C(F)(F)F)cc1Nc1ccccc1C(=O)O | 10.1021/acs.jmedchem.2c01997 | ||
| CHEMBL5289590 | 194578 | None | 0 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 306 | 3 | 2 | 3 | 4.0 | N#Cc1ccc(C(F)(F)F)cc1Nc1ccccc1C(=O)O | 10.1021/acs.jmedchem.2c01997 | ||
| 1193 | 1656 | None | 64 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 281 | 3 | 2 | 2 | 4.1 | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
| 2447 | 1656 | None | 64 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 281 | 3 | 2 | 2 | 4.1 | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
| 3371 | 1656 | None | 64 | Human | Binding | pEC50 | = | 6.4 | 6.4 | - | 0 | Agonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assayAgonist activity at human TAS2R14 transfected in HEK293T cells assessed as IP1 accumulation measured after 150 mins by IP1 accumulation assay |
ChEMBL | 281 | 3 | 2 | 2 | 4.1 | OC(=O)c1ccccc1Nc1cccc(c1)C(F)(F)F | 10.1021/acs.jmedchem.2c01997 | ||
Showing 1 to 50 of 309 entries