Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ligand		 Fold
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GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
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Description		 Source

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 DOI
12607 10556 42 None 1 4 Human 10.4 pEC50 = 10.4 Functional
Positive allosteric modulation of human C-terminal eYFP-fused human NY1 receptor expressed in African green monkey COS7 cells co-expressing delta6Galphaqi4-myr assessed as potentiation of neuropeptide Y-mediated Ca2+ flux by measuring pancreatic polypeptide EC50 at 30 uM treated at 20 secs post baseline detection followed by addition of neuropeptide Y after 140 secs by Fluo2-AM fluorescent dye-based assay (Rvb = 10.3 +/- 0.1 No_unit)Positive allosteric modulation of human C-terminal eYFP-fused human NY1 receptor expressed in African green monkey COS7 cells co-expressing delta6Galphaqi4-myr assessed as potentiation of neuropeptide Y-mediated Ca2+ flux by measuring pancreatic polypeptide EC50 at 30 uM treated at 20 secs post baseline detection followed by addition of neuropeptide Y after 140 secs by Fluo2-AM fluorescent dye-based assay (Rvb = 10.3 +/- 0.1 No_unit)
ChEMBL 248 2 1 2 3.7 CC(C)(C)C1=CC=C(C=C1)OC2CCCCC2O 10.1021/acs.jmedchem.7b00976
16033 10556 42 None 1 4 Human 10.4 pEC50 = 10.4 Functional
Positive allosteric modulation of human C-terminal eYFP-fused human NY1 receptor expressed in African green monkey COS7 cells co-expressing delta6Galphaqi4-myr assessed as potentiation of neuropeptide Y-mediated Ca2+ flux by measuring pancreatic polypeptide EC50 at 30 uM treated at 20 secs post baseline detection followed by addition of neuropeptide Y after 140 secs by Fluo2-AM fluorescent dye-based assay (Rvb = 10.3 +/- 0.1 No_unit)Positive allosteric modulation of human C-terminal eYFP-fused human NY1 receptor expressed in African green monkey COS7 cells co-expressing delta6Galphaqi4-myr assessed as potentiation of neuropeptide Y-mediated Ca2+ flux by measuring pancreatic polypeptide EC50 at 30 uM treated at 20 secs post baseline detection followed by addition of neuropeptide Y after 140 secs by Fluo2-AM fluorescent dye-based assay (Rvb = 10.3 +/- 0.1 No_unit)
ChEMBL 248 2 1 2 3.7 CC(C)(C)C1=CC=C(C=C1)OC2CCCCC2O 10.1021/acs.jmedchem.7b00976
CHEMBL3559801 10556 42 None 1 4 Human 10.4 pEC50 = 10.4 Functional
Positive allosteric modulation of human C-terminal eYFP-fused human NY1 receptor expressed in African green monkey COS7 cells co-expressing delta6Galphaqi4-myr assessed as potentiation of neuropeptide Y-mediated Ca2+ flux by measuring pancreatic polypeptide EC50 at 30 uM treated at 20 secs post baseline detection followed by addition of neuropeptide Y after 140 secs by Fluo2-AM fluorescent dye-based assay (Rvb = 10.3 +/- 0.1 No_unit)Positive allosteric modulation of human C-terminal eYFP-fused human NY1 receptor expressed in African green monkey COS7 cells co-expressing delta6Galphaqi4-myr assessed as potentiation of neuropeptide Y-mediated Ca2+ flux by measuring pancreatic polypeptide EC50 at 30 uM treated at 20 secs post baseline detection followed by addition of neuropeptide Y after 140 secs by Fluo2-AM fluorescent dye-based assay (Rvb = 10.3 +/- 0.1 No_unit)
ChEMBL 248 2 1 2 3.7 CC(C)(C)C1=CC=C(C=C1)OC2CCCCC2O 10.1021/acs.jmedchem.7b00976
56841989 220199 6 None -2 6 Human 10.0 pEC50 = 10 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4281479 220199 6 None -2 6 Human 10.0 pEC50 = 10 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4279973 220180 0 None 2 4 Human 9.7 pEC50 = 9.7 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4284905 220229 0 None 10 4 Human 9.7 pEC50 = 9.7 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
CHEMBL4286615 220243 0 None -1 4 Human 9.7 pEC50 = 9.7 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
CHEMBL4279973 220180 0 None 2 4 Human 9.7 pEC50 = 9.7 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4284905 220229 0 None 10 4 Human 9.7 pEC50 = 9.7 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
CHEMBL4286615 220243 0 None -1 4 Human 9.7 pEC50 = 9.7 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
3260593 123846 10 None -1 2 Human 5.0 pEC50 = 5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 434 2 0 4 6.1 Clc1ccc(-n2c(-c3cccc(Br)c3)nc3nc4ccccc4nc32)cc1 nan
CHEMBL3392057 123846 10 None -1 2 Human 5.0 pEC50 = 5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 434 2 0 4 6.1 Clc1ccc(-n2c(-c3cccc(Br)c3)nc3nc4ccccc4nc32)cc1 nan
135469963 115879 5 None -1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 443 6 1 6 4.1 O=C(/C(=N/Nc1cccc([N+](=O)[O-])c1)C(=O)C(F)(F)F)c1ccc(Br)cc1 nan
CHEMBL3213459 115879 5 None -1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 443 6 1 6 4.1 O=C(/C(=N/Nc1cccc([N+](=O)[O-])c1)C(=O)C(F)(F)F)c1ccc(Br)cc1 nan
1192552 28885 12 None -4 4 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 384 6 2 6 5.3 CCOC(=O)c1nc(Nc2ccc(Nc3ccccc3)cc2)c2ccccc2n1 nan
CHEMBL1322039 28885 12 None -4 4 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 384 6 2 6 5.3 CCOC(=O)c1nc(Nc2ccc(Nc3ccccc3)cc2)c2ccccc2n1 nan
2803877 27806 5 None 1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 497 7 3 6 5.6 O=[N+]([O-])c1cc(C(F)(F)F)cc([N+](=O)[O-])c1NCCN=C(S)Nc1ccc(Cl)c(Cl)c1 nan
CHEMBL1311742 27806 5 None 1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 497 7 3 6 5.6 O=[N+]([O-])c1cc(C(F)(F)F)cc([N+](=O)[O-])c1NCCN=C(S)Nc1ccc(Cl)c(Cl)c1 nan
693933 54504 14 None -3 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 327 3 1 3 3.9 Nc1cc(-c2ccc(Br)cc2)nn1Cc1ccccc1 nan
CHEMBL1547757 54504 14 None -3 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 327 3 1 3 3.9 Nc1cc(-c2ccc(Br)cc2)nn1Cc1ccccc1 nan
2809885 53364 4 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 317 6 2 3 2.8 OC(CNC1Cc2ccccc2C1)COc1ccc(Cl)cc1 nan
CHEMBL1538224 53364 4 None - 1 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 317 6 2 3 2.8 OC(CNC1Cc2ccccc2C1)COc1ccc(Cl)cc1 nan
3235884 58124 5 None 1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 466 8 3 9 1.7 CCSc1nnc(NC(=O)CCNS(=O)(=O)c2cc(Br)cnc2N)s1 nan
CHEMBL1581332 58124 5 None 1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 466 8 3 9 1.7 CCSc1nnc(NC(=O)CCNS(=O)(=O)c2cc(Br)cnc2N)s1 nan
9665691 115870 1 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 273 2 1 4 3.5 Fc1ccc2c(c1)/C(=N/Nc1ccccn1)CCS2 nan
CHEMBL3213319 115870 1 None -1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 273 2 1 4 3.5 Fc1ccc2c(c1)/C(=N/Nc1ccccn1)CCS2 nan
56209 26266 27 None 1 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 296 6 1 3 3.5 CCN(CC)CC(O)Cn1c2ccccc2c2ccccc21 nan
CHEMBL1299267 26266 27 None 1 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 296 6 1 3 3.5 CCN(CC)CC(O)Cn1c2ccccc2c2ccccc21 nan
CHEMBL4294277 220309 0 None -12 3 Human 6.9 pEC50 = 6.9 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
1799038 47246 11 None 1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 355 4 2 3 4.9 CC(=O)C(=Nc1ccc(Cl)cc1Cl)NNc1cccc(Cl)c1 nan
CHEMBL1482637 47246 11 None 1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 355 4 2 3 4.9 CC(=O)C(=Nc1ccc(Cl)cc1Cl)NNc1cccc(Cl)c1 nan
3431315 60409 6 None 1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 551 7 2 5 4.7 O=C(Nc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl)c1ccccc1NS(=O)(=O)c1ccc(F)cc1 nan
CHEMBL1602800 60409 6 None 1 2 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 551 7 2 5 4.7 O=C(Nc1cc(S(=O)(=O)N2CCCCC2)ccc1Cl)c1ccccc1NS(=O)(=O)c1ccc(F)cc1 nan
CHEMBL4294277 220309 0 None -12 3 Human 6.9 pEC50 = 6.9 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
1192552 28885 12 None -4 4 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 384 6 2 6 5.3 CCOC(=O)c1nc(Nc2ccc(Nc3ccccc3)cc2)c2ccccc2n1 nan
CHEMBL1322039 28885 12 None -4 4 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 384 6 2 6 5.3 CCOC(=O)c1nc(Nc2ccc(Nc3ccccc3)cc2)c2ccccc2n1 nan
3244114 29674 4 None -1 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 431 8 2 5 3.6 CCN(CC)S(=O)(=O)c1ccc2ncc(C(=O)NCCC3=CCCCC3)c(O)c2c1 nan
CHEMBL1329027 29674 4 None -1 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 431 8 2 5 3.6 CCN(CC)S(=O)(=O)c1ccc2ncc(C(=O)NCCC3=CCCCC3)c(O)c2c1 nan
CHEMBL3099724 217802 0 None -131 4 Human 6.9 pEC50 = 6.9 Functional
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/ml400335g
136217230 51301 1 None -1 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 442 6 1 9 3.7 COc1ccc(Nc2oc(/C=C3/SC(=S)N(CC4CCCO4)C3=O)nc2C#N)cc1 nan
CHEMBL1519588 51301 1 None -1 3 Human 4.9 pEC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 442 6 1 9 3.7 COc1ccc(Nc2oc(/C=C3/SC(=S)N(CC4CCCO4)C3=O)nc2C#N)cc1 nan
CHEMBL2371911 216930 0 None -3 2 Human 5.9 pEC50 = 5.9 Functional
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesisAgonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
CHEMBL3099723 217801 0 None -2 4 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)O[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/ml400335g
44667100 200199 8 None 2 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 281 4 1 3 3.8 CN(C)Cc1c(O)ccc2oc(Cc3ccccc3)cc12 nan
657581 200199 8 None 2 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 281 4 1 3 3.8 CN(C)Cc1c(O)ccc2oc(Cc3ccccc3)cc12 nan
CHEMBL526034 200199 8 None 2 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 281 4 1 3 3.8 CN(C)Cc1c(O)ccc2oc(Cc3ccccc3)cc12 nan
2191297 49931 9 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 408 7 0 8 3.3 C=CCN1C(=O)/C(=C/c2ccc(OC(C)=O)c(OCC)c2[N+](=O)[O-])SC1=S nan
CHEMBL1505552 49931 9 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 408 7 0 8 3.3 C=CCN1C(=O)/C(=C/c2ccc(OC(C)=O)c(OCC)c2[N+](=O)[O-])SC1=S nan
CHEMBL4278700 220169 0 None -79 4 Human 7.8 pEC50 = 7.8 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
CHEMBL4292105 220292 0 None -15 4 Human 7.8 pEC50 = 7.8 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
682797 56635 19 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 316 3 2 4 4.2 Oc1ccccc1Cn1c(-c2ccccc2O)nc2ccccc21 nan
CHEMBL1567983 56635 19 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 316 3 2 4 4.2 Oc1ccccc1Cn1c(-c2ccccc2O)nc2ccccc21 nan
3911588 58326 7 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 418 6 2 3 4.5 O=C(Cc1ccc(Cl)cc1)Nc1cccc(S(=O)(=O)Nc2ccccc2F)c1 nan
CHEMBL1583097 58326 7 None 1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 418 6 2 3 4.5 O=C(Cc1ccc(Cl)cc1)Nc1cccc(S(=O)(=O)Nc2ccccc2F)c1 nan
CHEMBL4278700 220169 0 None -79 4 Human 7.8 pEC50 = 7.8 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
CHEMBL4292105 220292 0 None -15 4 Human 7.8 pEC50 = 7.8 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL3099724 217802 0 None -131 4 Human 6.8 pEC50 = 6.8 Functional
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/ml400335g
9700449 119433 0 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 356 10 2 5 4.4 CCCOc1ccc(/C=N/Nc2ccc(C(=O)O)cc2)c(OCCC)c1 nan
CHEMBL3192204 119433 0 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 356 10 2 5 4.4 CCCOc1ccc(/C=N/Nc2ccc(C(=O)O)cc2)c(OCCC)c1 nan
CHEMBL3303291 119433 0 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 356 10 2 5 4.4 CCCOc1ccc(/C=N/Nc2ccc(C(=O)O)cc2)c(OCCC)c1 nan
2167979 41589 10 None -2 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 369 3 2 2 4.2 O=C(CC(O)(C(F)(F)F)C(F)(F)F)Nc1ccc(Cl)c(Cl)c1 nan
CHEMBL1431189 41589 10 None -2 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 369 3 2 2 4.2 O=C(CC(O)(C(F)(F)F)C(F)(F)F)Nc1ccc(Cl)c(Cl)c1 nan
3093479 27498 11 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 510 6 3 5 4.9 COc1ccc(N=C(S)NC(NC(=O)c2cccc(Cl)c2)C(Cl)(Cl)Cl)c([N+](=O)[O-])c1 nan
CHEMBL1309183 27498 11 None -1 2 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 510 6 3 5 4.9 COc1ccc(N=C(S)NC(NC(=O)c2cccc(Cl)c2)C(Cl)(Cl)Cl)c([N+](=O)[O-])c1 nan
67275 54168 72 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 311 2 2 2 4.8 Cc1ccc(Cl)cc1NC(=O)c1cc2ccccc2cc1O nan
CHEMBL1544847 54168 72 None -1 3 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 311 2 2 2 4.8 Cc1ccc(Cl)cc1NC(=O)c1cc2ccccc2cc1O nan
2090677 35563 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 337 3 2 3 4.5 O=C(Nc1sc2c(c1-c1nc3ccccc3[nH]1)CCCC2)C1CC1 nan
CHEMBL1378687 35563 6 None - 1 Human 4.8 pEC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 337 3 2 3 4.5 O=C(Nc1sc2c(c1-c1nc3ccccc3[nH]1)CCCC2)C1CC1 nan
3641052 55747 2 None -1 3 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 375 4 0 8 3.1 CCn1nc([N+](=O)[O-])c(C(C#N)c2nc3ccccc3s2)c(Cl)c1=O nan
CHEMBL1560379 55747 2 None -1 3 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 375 4 0 8 3.1 CCn1nc([N+](=O)[O-])c(C(C#N)c2nc3ccccc3s2)c(Cl)c1=O nan
984148 53773 4 None -1 3 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 356 6 3 6 3.9 CCCc1cc(-c2[nH]ncc2-c2ccc(C(=O)OCC)o2)c(O)cc1O nan
CHEMBL1541596 53773 4 None -1 3 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 356 6 3 6 3.9 CCCc1cc(-c2[nH]ncc2-c2ccc(C(=O)OCC)o2)c(O)cc1O nan
1326639 41657 10 None 1 3 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 373 4 1 4 3.7 O=C(Nc1ccccc1C(=O)N1CCCC1)c1ccc(Cl)c([N+](=O)[O-])c1 nan
CHEMBL1431891 41657 10 None 1 3 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 373 4 1 4 3.7 O=C(Nc1ccccc1C(=O)N1CCCC1)c1ccc(Cl)c([N+](=O)[O-])c1 nan
1479154 53280 14 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 359 5 1 5 3.1 COc1ccc(Cn2cnc3c(NS(C)(=O)=O)c(C)c(C)cc32)cc1 nan
CHEMBL1537587 53280 14 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 359 5 1 5 3.1 COc1ccc(Cn2cnc3c(NS(C)(=O)=O)c(C)c(C)cc32)cc1 nan
CHEMBL439904 220633 13 None -134 4 Human 5.7 pEC50 = 5.7 Functional
Agonist activity NPY1R (unknown origin) by CRE-luciferase reporter gene assayAgonist activity NPY1R (unknown origin) by CRE-luciferase reporter gene assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c00740
2985425 62626 12 None 1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 263 5 1 3 2.5 Cc1ccccc1OCC(O)CN1CCC(C)CC1 nan
CHEMBL1538646 62626 12 None 1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 263 5 1 3 2.5 Cc1ccccc1OCC(O)CN1CCC(C)CC1 nan
CHEMBL1623239 62626 12 None 1 2 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 263 5 1 3 2.5 Cc1ccccc1OCC(O)CN1CCC(C)CC1 nan
4539353 31624 10 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 442 4 1 5 3.6 O=C(O)C1CC=CCC1C(=O)N1CCN(c2nc(-c3ccccc3)c3ccccc3n2)CC1 nan
660299 31624 10 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 442 4 1 5 3.6 O=C(O)C1CC=CCC1C(=O)N1CCN(c2nc(-c3ccccc3)c3ccccc3n2)CC1 nan
CHEMBL1345141 31624 10 None - 1 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 442 4 1 5 3.6 O=C(O)C1CC=CCC1C(=O)N1CCN(c2nc(-c3ccccc3)c3ccccc3n2)CC1 nan
1636339 51110 17 None -2 3 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 452 2 0 7 6.2 Cc1cc2c(cc1C)N(C(=O)CSC1=NCCS1)C(C)(C)c1ssc(=S)c1-2 nan
CHEMBL1517881 51110 17 None -2 3 Human 4.7 pEC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 452 2 0 7 6.2 Cc1cc2c(cc1C)N(C(=O)CSC1=NCCS1)C(C)(C)c1ssc(=S)c1-2 nan
CHEMBL3099721 217799 0 None -741 4 Human 6.7 pEC50 = 6.7 Functional
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/ml400335g
CHEMBL2371908 216927 0 None -16 2 Human 6.6 pEC50 = 6.6 Functional
Agonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesisAgonist activity at human NPY1 receptor in CHO cells by inhibition of forskolin-stimulated cAMP synthesis
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050907d
2315927 61933 2 None -1 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 427 5 0 1 7.0 CN(C)c1ccc(-[n+]2c(-c3ccccc3)cc(-c3ccccc3)cc2-c2ccccc2)cc1 nan
CHEMBL1343823 61933 2 None -1 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 427 5 0 1 7.0 CN(C)c1ccc(-[n+]2c(-c3ccccc3)cc(-c3ccccc3)cc2-c2ccccc2)cc1 nan
CHEMBL1617313 61933 2 None -1 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 427 5 0 1 7.0 CN(C)c1ccc(-[n+]2c(-c3ccccc3)cc(-c3ccccc3)cc2-c2ccccc2)cc1 nan
2816767 26675 6 None -1 3 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 356 3 2 6 5.1 Nc1sc(-c2ccccc2)cc1-c1nnc(S)n1C1CCCCC1 nan
CHEMBL1302519 26675 6 None -1 3 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 356 3 2 6 5.1 Nc1sc(-c2ccccc2)cc1-c1nnc(S)n1C1CCCCC1 nan
2945839 37248 12 None -1 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 487 8 2 8 3.5 COC(=O)c1ccc(NC(=O)CSc2nnc(C(C)NC(=O)c3ccccc3Cl)n2C)cc1 nan
CHEMBL1392858 37248 12 None -1 2 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 487 8 2 8 3.5 COC(=O)c1ccc(NC(=O)CSc2nnc(C(C)NC(=O)c3ccccc3Cl)n2C)cc1 nan
12004459 40098 1 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 407 6 2 6 3.4 O=C1C2CC=CCC2C(=O)N1c1ccc(NCCc2ccc(O)cc2)c([N+](=O)[O-])c1 nan
CHEMBL1418821 40098 1 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 407 6 2 6 3.4 O=C1C2CC=CCC2C(=O)N1c1ccc(NCCc2ccc(O)cc2)c([N+](=O)[O-])c1 nan
1929802 45487 10 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 414 5 4 3 5.1 CCOc1ccc(NC(S)=NN=C(S)Nc2cccc(C(F)(F)F)c2)cc1 nan
CHEMBL1465891 45487 10 None - 1 Human 4.6 pEC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 414 5 4 3 5.1 CCOc1ccc(NC(S)=NN=C(S)Nc2cccc(C(F)(F)F)c2)cc1 nan
660707 43245 12 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 251 2 1 2 4.1 CC(=O)Nc1ccc(-c2cc3ccccc3o2)cc1 nan
CHEMBL1447448 43245 12 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 251 2 1 2 4.1 CC(=O)Nc1ccc(-c2cc3ccccc3o2)cc1 nan
653127 61878 12 None 1 4 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 275 1 1 3 3.8 Cc1cccc(N2CCc3c2nc2ccccc2c3N)c1 nan
CHEMBL1366633 61878 12 None 1 4 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 275 1 1 3 3.8 Cc1cccc(N2CCc3c2nc2ccccc2c3N)c1 nan
CHEMBL1454903 61878 12 None 1 4 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 275 1 1 3 3.8 Cc1cccc(N2CCc3c2nc2ccccc2c3N)c1 nan
CHEMBL1616892 61878 12 None 1 4 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 275 1 1 3 3.8 Cc1cccc(N2CCc3c2nc2ccccc2c3N)c1 nan
CHEMBL4277676 220154 0 None -63 3 Human 6.5 pEC50 = 6.5 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4280392 220185 0 None -39 4 Human 6.5 pEC50 = 6.5 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4277676 220154 0 None -63 3 Human 6.5 pEC50 = 6.5 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4280392 220185 0 None -39 4 Human 6.5 pEC50 = 6.5 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
5883623 79441 3 None -2 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 288 4 2 5 2.2 N#C/C(=N/Nc1ccc(OC(F)(F)F)cc1)C(N)=S nan
CHEMBL1995800 79441 3 None -2 2 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 288 4 2 5 2.2 N#C/C(=N/Nc1ccc(OC(F)(F)F)cc1)C(N)=S nan
3148028 30581 17 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 313 5 1 6 2.7 O=C(COc1ccc(Cl)cc1)Nc1ncc([N+](=O)[O-])s1 nan
CHEMBL1336098 30581 17 None - 1 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 313 5 1 6 2.7 O=C(COc1ccc(Cl)cc1)Nc1ncc([N+](=O)[O-])s1 nan
16192803 54673 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 413 2 2 5 5.0 Cc1cccc2c(N)c3c(nc12)CCCC3.O=C(O)c1cc([N+](=O)[O-])ccc1Cl nan
CHEMBL1549309 54673 0 None 1 2 Human 5.5 pEC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 413 2 2 5 5.0 Cc1cccc2c(N)c3c(nc12)CCCC3.O=C(O)c1cc([N+](=O)[O-])ccc1Cl nan
1786 9298 85 None -363 7 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
4171 9298 85 None -363 7 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
553 9298 85 None -363 7 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
CHEMBL13 9298 85 None -363 7 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
DB00264 9298 85 None -363 7 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
570353 49838 6 None -134 4 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 464 5 2 6 4.9 O=C(NC(Nc1nc2ccc([N+](=O)[O-])cc2s1)(C(F)(F)F)C(F)(F)F)c1ccccc1 nan
CHEMBL1504701 49838 6 None -134 4 Human 4.5 pEC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 464 5 2 6 4.9 O=C(NC(Nc1nc2ccc([N+](=O)[O-])cc2s1)(C(F)(F)F)C(F)(F)F)c1ccccc1 nan
CHEMBL3099722 217800 0 None -173 4 Human 6.4 pEC50 = 6.4 Functional
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)O[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/ml400335g
CHEMBL439904 220633 13 None -134 4 Human 8.3 pEC50 = 8.3 Functional
Agonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assayAgonist activity at human NPYY1 receptor expressed in HEK293 cells assessed as decrease in isoproterenol-induced cAMP level measured every 30 secs for 360 secs by FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/ml400335g
2836861 39209 5 None 2 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 368 9 1 4 3.9 CCOC(=O)C(Cc1ccccc1)C(=O)Nc1ccc(N(CC)CC)cc1 nan
CHEMBL1411397 39209 5 None 2 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1546 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 368 9 1 4 3.9 CCOC(=O)C(Cc1ccccc1)C(=O)Nc1ccc(N(CC)CC)cc1 nan
16192803 54673 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 413 2 2 5 5.0 Cc1cccc2c(N)c3c(nc12)CCCC3.O=C(O)c1cc([N+](=O)[O-])ccc1Cl nan
CHEMBL1549309 54673 0 None 1 2 Human 5.3 pEC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for potentiators or agonists of NPY-Y2: cell-based high-throughput dose response assay for potentiators or agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1539 (Screening assay (NPY-Y2 potentiators or agonists).), 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1791 (Summary AID.)]
ChEMBL 413 2 2 5 5.0 Cc1cccc2c(N)c3c(nc12)CCCC3.O=C(O)c1cc([N+](=O)[O-])ccc1Cl nan
2803877 27806 5 None 1 3 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 497 7 3 6 5.6 O=[N+]([O-])c1cc(C(F)(F)F)cc([N+](=O)[O-])c1NCCN=C(S)Nc1ccc(Cl)c(Cl)c1 nan
CHEMBL1311742 27806 5 None 1 3 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 497 7 3 6 5.6 O=[N+]([O-])c1cc(C(F)(F)F)cc([N+](=O)[O-])c1NCCN=C(S)Nc1ccc(Cl)c(Cl)c1 nan
7066599 51267 10 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 293 3 1 4 4.5 Fc1ccc(Nc2c(-c3ccco3)nc3ccccn23)cc1 nan
CHEMBL1519263 51267 10 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 293 3 1 4 4.5 Fc1ccc(Nc2c(-c3ccco3)nc3ccccn23)cc1 nan
1078087 34898 41 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 220 2 2 3 2.1 Cc1c(C(=O)O)[nH]c2ccc([N+](=O)[O-])cc12 nan
CHEMBL1373205 34898 41 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 220 2 2 3 2.1 Cc1c(C(=O)O)[nH]c2ccc([N+](=O)[O-])cc12 nan
2836861 39209 5 None 2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 368 9 1 4 3.9 CCOC(=O)C(Cc1ccccc1)C(=O)Nc1ccc(N(CC)CC)cc1 nan
CHEMBL1411397 39209 5 None 2 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 368 9 1 4 3.9 CCOC(=O)C(Cc1ccccc1)C(=O)Nc1ccc(N(CC)CC)cc1 nan
1206899 57279 18 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 174 1 2 5 1.0 N#Cc1c(Cl)nsc1NN nan
CHEMBL1573719 57279 18 None 1 2 Human 5.2 pEC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 174 1 2 5 1.0 N#Cc1c(Cl)nsc1NN nan
2185441 26602 9 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 443 6 2 7 5.2 CCn1c(SCC(=O)Nc2ccc3c(c2)oc2ccccc23)nnc1-c1ccc(N)cc1 nan
CHEMBL1301994 26602 9 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 443 6 2 7 5.2 CCn1c(SCC(=O)Nc2ccc3c(c2)oc2ccccc23)nnc1-c1ccc(N)cc1 nan
2405497 35156 7 None -1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 431 5 2 5 5.9 Nc1c(-c2ccccc2)c(CSc2nc3ccccc3[nH]2)nn1-c1ccc(Cl)cc1 nan
CHEMBL1374954 35156 7 None -1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 431 5 2 5 5.9 Nc1c(-c2ccccc2)c(CSc2nc3ccccc3[nH]2)nn1-c1ccc(Cl)cc1 nan
3562031 57149 15 None -1 3 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 445 4 2 3 4.1 O=C(Nc1ccc(Cl)cc1Cl)NC1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 nan
CHEMBL1572588 57149 15 None -1 3 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 445 4 2 3 4.1 O=C(Nc1ccc(Cl)cc1Cl)NC1CCN(S(=O)(=O)c2ccc(F)cc2)CC1 nan
CHEMBL4277590 220152 0 None -50 3 Human 7.1 pEC50 = 7.1 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4277590 220152 0 None -50 3 Human 7.1 pEC50 = 7.1 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4279794 220178 0 None -794 4 Human 6.1 pEC50 = 6.1 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4279794 220178 0 None -794 4 Human 6.1 pEC50 = 6.1 Functional
Activation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assayActivation of human Y1R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
4055293 61873 8 None 1 3 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 392 2 0 2 6.1 Cc1sc2cc3c(c(C(=O)c4ccccc4)[n+]2c1C)-c1cccc2cccc-3c12 nan
CHEMBL1366987 61873 8 None 1 3 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 392 2 0 2 6.1 Cc1sc2cc3c(c(C(=O)c4ccccc4)[n+]2c1C)-c1cccc2cccc-3c12 nan
CHEMBL1616832 61873 8 None 1 3 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 392 2 0 2 6.1 Cc1sc2cc3c(c(C(=O)c4ccccc4)[n+]2c1C)-c1cccc2cccc-3c12 nan
3237370 54592 6 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 366 8 1 4 3.3 C=CCc1ccccc1OCC(O)CN1CCN(c2ccc(C)cc2)CC1 nan
CHEMBL1548605 54592 6 None 1 2 Human 5.1 pEC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 366 8 1 4 3.3 C=CCc1ccccc1OCC(O)CN1CCN(c2ccc(C)cc2)CC1 nan
5710119 114780 9 None 1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 283 4 1 4 3.5 N#C/C(=N\Nc1ccc(Cl)cc1)C(=O)c1ccccc1 nan
CHEMBL3194195 114780 9 None 1 3 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 283 4 1 4 3.5 N#C/C(=N\Nc1ccc(Cl)cc1)C(=O)c1ccccc1 nan
2919986 62062 6 None 1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 387 8 1 7 2.2 COc1ccc(N2CCN(CC(O)COc3ccccc3[N+](=O)[O-])CC2)cc1 nan
CHEMBL1342462 62062 6 None 1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 387 8 1 7 2.2 COc1ccc(N2CCN(CC(O)COc3ccccc3[N+](=O)[O-])CC2)cc1 nan
CHEMBL1618362 62062 6 None 1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 387 8 1 7 2.2 COc1ccc(N2CCN(CC(O)COc3ccccc3[N+](=O)[O-])CC2)cc1 nan
1786 9298 85 None -363 7 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
4171 9298 85 None -363 7 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
553 9298 85 None -363 7 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
CHEMBL13 9298 85 None -363 7 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
DB00264 9298 85 None -363 7 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 267 9 2 4 1.6 COCCc1ccc(cc1)OCC(CNC(C)C)O nan
708088 27954 11 None 1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 328 4 1 5 3.6 Cn1cc([N+](=O)[O-])c(C(=O)Nc2ccc(C3CCCCC3)cc2)n1 nan
CHEMBL1312767 27954 11 None 1 2 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based dose response cell-based high-throughput screening assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1697 (Screening assay (NPY-Y1 agonists).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1704 (Screening assay (CNGC inhibitors).), 1791 (Summary AID.)]
ChEMBL 328 4 1 5 3.6 Cn1cc([N+](=O)[O-])c(C(=O)Nc2ccc(C3CCCCC3)cc2)n1 nan
3598 194600 76 None -13 17 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
CHEMBL496 194600 76 None -13 17 Human 5.0 pEC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 404 2 2 2 6.6 Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl nan
3117655 46123 4 None 1 2 Human 5.0 pEC50 = 5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 322 4 1 5 3.3 CC1=NC(=O)C(N=Nc2ccccc2C(=O)O)N1c1ccccc1 nan
CHEMBL1471202 46123 4 None 1 2 Human 5.0 pEC50 = 5 Functional
PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]PUBCHEM_BIOASSAY: Fluorescence-based counterscreen for agonists of NPY-Y2: cell-based high-throughput dose response assay for agonists of NPY-Y1. (Class of assay: confirmatory) [Related pubchem assays: 1703 (Screening assay (CNGC inhibitors).), 1359 (Screening assay (NPY-Y2 potentiators or agonists).), 1304 (Screening assay (NPY-Y1 potentiators or agonists).), 1710 (Screening assay (NPY-Y2 agonists).), 1791 (Summary AID.)]
ChEMBL 322 4 1 5 3.3 CC1=NC(=O)C(N=Nc2ccccc2C(=O)O)N1c1ccccc1 nan
162647593 190417 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 619 15 7 5 1.8 N/C(=N/C(=O)NCCNC(=O)CF)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4746035 190417 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 619 15 7 5 1.8 N/C(=N/C(=O)NCCNC(=O)CF)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802520 190417 0 None - 1 Human 10.3 pIC50 = 10.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 619 15 7 5 1.8 N/C(=N/C(=O)NCCNC(=O)CF)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162667448 190516 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 679 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)CBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4786911 190516 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 679 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)CBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803593 190516 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 679 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)CBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162655600 190455 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 629 15 7 5 2.5 CC(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4755692 190455 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 629 15 7 5 2.5 CC(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802951 190455 0 None - 1 Human 10.2 pIC50 = 10.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 629 15 7 5 2.5 CC(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162673313 190550 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 635 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)CCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4794692 190550 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 635 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)CCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803933 190550 0 None - 1 Human 10.1 pIC50 = 10.1 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 635 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)CCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162675643 190563 0 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 617 15 8 6 0.8 N/C(=N/C(=O)NCCNC(=O)CO)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4798118 190563 0 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 617 15 8 6 0.8 N/C(=N/C(=O)NCCNC(=O)CO)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4804067 190563 0 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 617 15 8 6 0.8 N/C(=N/C(=O)NCCNC(=O)CO)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162645700 190408 0 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 637 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)C(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4743858 190408 0 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 637 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)C(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802419 190408 0 None - 1 Human 10.0 pIC50 = 10.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 637 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)C(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162652126 190434 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 655 14 7 5 2.4 N/C(=N/C(=O)NCCNC(=O)C(F)(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4751322 190434 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 655 14 7 5 2.4 N/C(=N/C(=O)NCCNC(=O)C(F)(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802763 190434 0 None - 1 Human 9.9 pIC50 = 9.9 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 655 14 7 5 2.4 N/C(=N/C(=O)NCCNC(=O)C(F)(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162653845 190446 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 613 15 7 5 2.0 C=CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4753520 190446 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 613 15 7 5 2.0 C=CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802860 190446 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 613 15 7 5 2.0 C=CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162649085 190421 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 627 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)C1CC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4745338 190421 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 627 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)C1CC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802600 190421 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 627 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)C1CC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162659745 190478 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 641 15 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)C1CCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4762044 190478 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 641 15 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)C1CCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803174 190478 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 641 15 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)C1CCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162653308 190444 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 616 15 8 6 0.8 NCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4752935 190444 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 616 15 8 6 0.8 NCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802829 190444 0 None - 1 Human 9.6 pIC50 = 9.6 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 616 15 8 6 0.8 NCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162669845 190527 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 693 16 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)CCBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4789673 190527 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 693 16 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)CCBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803729 190527 0 None - 1 Human 9.4 pIC50 = 9.4 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 693 16 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)CCBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162672910 190549 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 649 16 7 5 2.5 N/C(=N/C(=O)NCCNC(=O)CCCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4795468 190549 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 649 16 7 5 2.5 N/C(=N/C(=O)NCCNC(=O)CCCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803913 190549 0 None - 1 Human 9.2 pIC50 = 9.2 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 649 16 7 5 2.5 N/C(=N/C(=O)NCCNC(=O)CCCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
9959777 203449 9 None - 1 Human 8.9 pIC50 = 8.9 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 571 10 2 8 6.8 CCc1sc(CCc2cc(N3CCOCC3)cc(NC(C)c3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2009.05.069
CHEMBL564536 203449 9 None - 1 Human 8.9 pIC50 = 8.9 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 571 10 2 8 6.8 CCc1sc(CCc2cc(N3CCOCC3)cc(NC(C)c3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2009.05.069
44288313 169884 0 None - 1 Human 7.0 pIC50 = 7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 525 11 5 3 4.2 N=C(N)NCCCC(NC(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL417711 169884 0 None - 1 Human 7.0 pIC50 = 7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 525 11 5 3 4.2 N=C(N)NCCCC(NC(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
44288022 173312 0 None - 1 Human 6.0 pIC50 = 6 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 499 10 6 4 3.1 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NC1CCc2cc(O)ccc21 10.1016/s0960-894x(00)00292-4
CHEMBL42793 173312 0 None - 1 Human 6.0 pIC50 = 6 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 499 10 6 4 3.1 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NC1CCc2cc(O)ccc21 10.1016/s0960-894x(00)00292-4
563820 62307 7 None -2 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 321 3 1 2 4.3 OC1(c2ccccc2)CCN(Cc2ccccc2)C2CCCCC21 nan
CHEMBL1426022 62307 7 None -2 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 321 3 1 2 4.3 OC1(c2ccccc2)CCN(Cc2ccccc2)C2CCCCC21 nan
CHEMBL1620460 62307 7 None -2 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 321 3 1 2 4.3 OC1(c2ccccc2)CCN(Cc2ccccc2)C2CCCCC21 nan
2942743 48583 9 None -2 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 367 5 1 2 6.1 CC(Sc1ccc(Cl)cc1)C(=O)Nc1ccccc1-c1ccccc1 nan
CHEMBL1493277 48583 9 None -2 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 367 5 1 2 6.1 CC(Sc1ccc(Cl)cc1)C(=O)Nc1ccccc1-c1ccccc1 nan
9594209 114766 3 None -2 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 538 12 2 7 3.0 COc1ccc(/C=N/NC(=O)CN(CCc2ccccc2)S(=O)(=O)c2ccc(NC(C)=O)cc2)cc1OC nan
CHEMBL3194054 114766 3 None -2 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 538 12 2 7 3.0 COc1ccc(/C=N/NC(=O)CN(CCc2ccccc2)S(=O)(=O)c2ccc(NC(C)=O)cc2)cc1OC nan
3340390 36364 9 None -6 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 528 14 0 2 7.7 O=P(CCCCCCCCCP(=O)(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1 nan
CHEMBL1385608 36364 9 None -6 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 528 14 0 2 7.7 O=P(CCCCCCCCCP(=O)(c1ccccc1)c1ccccc1)(c1ccccc1)c1ccccc1 nan
44634614 79691 0 None -2 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 528 2 3 5 3.8 C/C1=C/[C@@H](C)C/C=C/[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@]23C(=O)/C=C\C(=O)[C@@H]1O nan
CHEMBL2004475 79691 0 None -2 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 528 2 3 5 3.8 C/C1=C/[C@@H](C)C/C=C/[C@H]2[C@@H]3O[C@]3(C)[C@@H](C)[C@H]3[C@H](Cc4c[nH]c5ccccc45)NC(=O)[C@@]23C(=O)/C=C\C(=O)[C@@H]1O nan
16192223 41046 5 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 403 7 1 5 4.6 Cc1ccc(-n2cc(CNCCn3nc(C)cc3C)c(-c3ccc(F)cc3)n2)cc1 nan
CHEMBL1426722 41046 5 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 403 7 1 5 4.6 Cc1ccc(-n2cc(CNCCn3nc(C)cc3C)c(-c3ccc(F)cc3)n2)cc1 nan
162670721 190531 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 663 15 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4792205 190531 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 663 15 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803781 190531 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 663 15 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44288140 107129 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 457 11 5 3 2.9 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL289620 107129 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 457 11 5 3 2.9 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
44288235 175422 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 531 9 4 3 4.2 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
CHEMBL43627 175422 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 531 9 4 3 4.2 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
865459 32186 5 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 244 3 0 4 3.2 CCSc1nc2ccc(OC)cc2cc1C#N nan
CHEMBL1349920 32186 5 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 244 3 0 4 3.2 CCSc1nc2ccc(OC)cc2cc1C#N nan
2948077 31266 17 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 327 4 0 6 3.6 O=C(CSc1nc2ccccc2o1)c1ccc2c(c1)OCCO2 nan
CHEMBL1342128 31266 17 None 1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 327 4 0 6 3.6 O=C(CSc1nc2ccccc2o1)c1ccc2c(c1)OCCO2 nan
44287731 168535 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 472 12 5 4 2.3 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCCc1ccccn1 10.1016/s0960-894x(00)00292-4
CHEMBL41392 168535 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 472 12 5 4 2.3 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCCc1ccccn1 10.1016/s0960-894x(00)00292-4
2788869 40638 12 None -2 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 444 8 0 6 5.4 CCC(Oc1ccc2c(=O)c(-c3ccccc3OC)coc2c1)C(=O)OCc1ccccc1 nan
CHEMBL1423382 40638 12 None -2 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 444 8 0 6 5.4 CCC(Oc1ccc2c(=O)c(-c3ccccc3OC)coc2c1)C(=O)OCc1ccccc1 nan
2243399 44319 9 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 254 4 1 4 2.8 C=CCNc1nc(N2CCCC2)nc2ccccc12 nan
CHEMBL1456185 44319 9 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 254 4 1 4 2.8 C=CCNc1nc(N2CCCC2)nc2ccccc12 nan
44287938 107186 0 None -20 3 Human 4.9 pIC50 = 4.9 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 631 13 4 4 5.4 N/C(=N/CCCC(NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCCc2cc(O)ccc2C1)NCCCc1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL290175 107186 0 None -20 3 Human 4.9 pIC50 = 4.9 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 631 13 4 4 5.4 N/C(=N/CCCC(NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCCc2cc(O)ccc2C1)NCCCc1ccccc1 10.1016/s0960-894x(00)00292-4
56841989 220199 6 None -2 6 Human 7.9 pIC50 = 7.9 Functional
Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assayAgonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c01783
CHEMBL4281479 220199 6 None -2 6 Human 7.9 pIC50 = 7.9 Functional
Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assayAgonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c01783
44288311 162426 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 565 9 4 3 4.8 N=C(N)NCCCC(NC(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
CHEMBL40475 162426 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 565 9 4 3 4.8 N=C(N)NCCCC(NC(=O)C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
1504749 36138 12 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 308 4 1 6 2.5 Cc1ccc(COC(=O)c2nn(-c3ccccc3)nc2N)cc1 nan
CHEMBL1383610 36138 12 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 308 4 1 6 2.5 Cc1ccc(COC(=O)c2nn(-c3ccccc3)nc2N)cc1 nan
5140222 52921 9 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 402 8 1 4 4.5 CCC(C)(C(=O)NC1CCCCC1)N(Cc1ccco1)C(=O)Cc1cccs1 nan
CHEMBL1533962 52921 9 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 402 8 1 4 4.5 CCC(C)(C(=O)NC1CCCCC1)N(Cc1ccco1)C(=O)Cc1cccs1 nan
2085549 60201 6 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 357 5 0 7 5.2 c1ccc(-c2nc(CSc3nnc(-c4cccs4)o3)cs2)cc1 nan
CHEMBL1600727 60201 6 None 1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 357 5 0 7 5.2 c1ccc(-c2nc(CSc3nnc(-c4cccs4)o3)cs2)cc1 nan
45267382 203168 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 374 9 1 7 2.6 CCc1oc(CCc2cc(N3CCOCC3)cc(NCCOC)n2)nc1C 10.1016/j.bmcl.2009.05.069
CHEMBL562677 203168 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 374 9 1 7 2.6 CCc1oc(CCc2cc(N3CCOCC3)cc(NCCOC)n2)nc1C 10.1016/j.bmcl.2009.05.069
2862130 26460 13 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 386 4 0 4 4.5 CCC1=Nc2ccc(Br)cc2C(c2ccccc2)N1CC(=O)OC nan
CHEMBL1300782 26460 13 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 386 4 0 4 4.5 CCC1=Nc2ccc(Br)cc2C(c2ccccc2)N1CC(=O)OC nan
1816029 33203 8 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 294 5 0 4 3.6 CCCCOc1nc2ccccc2c(=O)n1-c1ccccc1 nan
CHEMBL1359694 33203 8 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 294 5 0 4 3.6 CCCCOc1nc2ccccc2c(=O)n1-c1ccccc1 nan
854958 39352 9 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 324 3 3 5 3.4 CCc1cc(-c2[nH]ncc2-c2ccc3c(c2)OCO3)c(O)cc1O nan
CHEMBL1412538 39352 9 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 324 3 3 5 3.4 CCc1cc(-c2[nH]ncc2-c2ccc3c(c2)OCO3)c(O)cc1O nan
2285391 32388 9 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 349 8 1 3 4.1 Cc1cccc(CSCCNC(=O)COc2ccc(Cl)cc2)c1 nan
CHEMBL1351633 32388 9 None - 1 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 349 8 1 3 4.1 Cc1cccc(CSCCNC(=O)COc2ccc(Cl)cc2)c1 nan
860841 42341 7 None -1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 327 3 0 6 3.7 Clc1ccc(-c2nnn(Cc3nc4ccccc4s3)n2)cc1 nan
CHEMBL1439255 42341 7 None -1 3 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 327 3 0 6 3.7 Clc1ccc(-c2nnn(Cc3nc4ccccc4s3)n2)cc1 nan
667608 61872 10 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 299 4 0 3 4.3 CN1CCC(Oc2ccccc2Sc2ccccc2)CC1 nan
CHEMBL1364371 61872 10 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 299 4 0 3 4.3 CN1CCC(Oc2ccccc2Sc2ccccc2)CC1 nan
CHEMBL1616825 61872 10 None 1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 299 4 0 3 4.3 CN1CCC(Oc2ccccc2Sc2ccccc2)CC1 nan
12004848 33851 1 None -2 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 246 5 1 3 2.5 CCCCOc1ccc(C2=NNC(=O)CC2)cc1 nan
CHEMBL1365319 33851 1 None -2 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 246 5 1 3 2.5 CCCCOc1ccc(C2=NNC(=O)CC2)cc1 nan
5132730 32568 11 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 354 9 2 4 2.7 CCCCCCNS(=O)(=O)c1ccc(NC(=O)C2CCCO2)cc1 nan
CHEMBL1353075 32568 11 None -1 2 Human 4.9 pIC50 = 4.9 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 354 9 2 4 2.7 CCCCCCNS(=O)(=O)c1ccc(NC(=O)C2CCCO2)cc1 nan
162655171 190452 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 643 14 7 5 2.9 CC(C)(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4756494 190452 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 643 14 7 5 2.9 CC(C)(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802928 190452 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 643 14 7 5 2.9 CC(C)(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44287998 162330 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 483 10 5 3 3.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H]1CCc2ccccc21 10.1016/s0960-894x(00)00292-4
CHEMBL40430 162330 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 483 10 5 3 3.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H]1CCc2ccccc21 10.1016/s0960-894x(00)00292-4
11958626 37048 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 352 8 2 5 3.3 CCCCNC(=O)c1onc(CSc2ccccc2F)c1C(=O)O nan
CHEMBL1391119 37048 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 352 8 2 5 3.3 CCCCNC(=O)c1onc(CSc2ccccc2F)c1C(=O)O nan
9869677 68419 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
ChEMBL 477 8 2 7 4.9 CCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771260 68419 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
ChEMBL 477 8 2 7 4.9 CCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
44229545 202828 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 375 6 1 8 3.2 Cc1nc(SCc2cc(N3CCOCC3)cc(NCC#N)n2)sc1C 10.1016/j.bmcl.2009.05.069
CHEMBL560382 202828 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 375 6 1 8 3.2 Cc1nc(SCc2cc(N3CCOCC3)cc(NCC#N)n2)sc1C 10.1016/j.bmcl.2009.05.069
45269118 203185 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 402 9 1 8 2.5 CCOC(=O)CNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1 10.1016/j.bmcl.2009.05.069
CHEMBL562831 203185 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 402 9 1 8 2.5 CCOC(=O)CNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1 10.1016/j.bmcl.2009.05.069
3487983 62779 1 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 289 1 0 1 3.9 CC1CC(C)CN(C2=CC(=[N+]3CCCC3)CC(C)(C)C2)C1 nan
CHEMBL1550184 62779 1 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 289 1 0 1 3.9 CC1CC(C)CN(C2=CC(=[N+]3CCCC3)CC(C)(C)C2)C1 nan
CHEMBL1624501 62779 1 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 289 1 0 1 3.9 CC1CC(C)CN(C2=CC(=[N+]3CCCC3)CC(C)(C)C2)C1 nan
162662291 190493 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 681 15 7 5 3.3 N/C(=N/C(=O)NCCNC(=O)c1ccc(F)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4764296 190493 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 681 15 7 5 3.3 N/C(=N/C(=O)NCCNC(=O)c1ccc(F)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803298 190493 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 681 15 7 5 3.3 N/C(=N/C(=O)NCCNC(=O)c1ccc(F)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
45268225 203446 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 344 7 1 6 3.0 CCNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1 10.1016/j.bmcl.2009.05.069
CHEMBL564513 203446 0 None - 1 Human 4.8 pIC50 = 4.8 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 344 7 1 6 3.0 CCNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1 10.1016/j.bmcl.2009.05.069
16192231 49770 7 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 375 7 0 4 4.6 CCOC(=O)C1(CCCc2ccccc2)CCN(C2CCSCC2)CC1 nan
CHEMBL1504083 49770 7 None - 1 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 375 7 0 4 4.6 CCOC(=O)C1(CCCc2ccccc2)CCN(C2CCSCC2)CC1 nan
11958550 55220 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 368 8 2 5 3.8 CCCCNC(=O)c1onc(CSc2ccc(Cl)cc2)c1C(=O)O nan
CHEMBL1555711 55220 0 None -1 2 Human 4.8 pIC50 = 4.8 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 368 8 2 5 3.8 CCCCNC(=O)c1onc(CSc2ccc(Cl)cc2)c1C(=O)O nan
21129772 176203 4 None 7943 2 Human 7.8 pIC50 = 7.8 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
CHEMBL44246 176203 4 None 7943 2 Human 7.8 pIC50 = 7.8 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
2669460 54220 6 None - 1 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 323 4 1 3 4.5 CC(C)(C)NC(=O)c1oc2ccccc2c1COc1ccccc1 nan
CHEMBL1545205 54220 6 None - 1 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 323 4 1 3 4.5 CC(C)(C)NC(=O)c1oc2ccccc2c1COc1ccccc1 nan
3849628 115184 14 None 1 2 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 377 7 1 7 3.9 CCOC(=O)C(/C=N/c1cc(C)nn1-c1ccc(Cl)cc1)=C(\O)OCC nan
CHEMBL3198593 115184 14 None 1 2 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 377 7 1 7 3.9 CCOC(=O)C(/C=N/c1cc(C)nn1-c1ccc(Cl)cc1)=C(\O)OCC nan
1915932 32246 6 None -1 2 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 412 5 1 4 5.1 CC(C)OC(=O)/C(=C/c1ccc2c(c1)c1ccccc1n2C)NC(=O)c1ccccc1 nan
CHEMBL1350415 32246 6 None -1 2 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 412 5 1 4 5.1 CC(C)OC(=O)/C(=C/c1ccc2c(c1)c1ccccc1n2C)NC(=O)c1ccccc1 nan
1283502 53430 14 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 440 7 1 7 4.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2ccc(O)c(CN3CCOCC3)c12 nan
CHEMBL1538792 53430 14 None 4 2 Human 5.7 pIC50 = 5.7 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 440 7 1 7 4.2 CCOC(=O)c1c(CSc2ccccc2)n(C)c2ccc(O)c(CN3CCOCC3)c12 nan
44287999 169266 0 None 275 2 Human 6.7 pIC50 = 6.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 471 11 4 3 3.2 C[C@@H](NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL41673 169266 0 None 275 2 Human 6.7 pIC50 = 6.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 471 11 4 3 3.2 C[C@@H](NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00292-4
4896972 31227 9 None -2 3 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 457 5 1 6 4.6 Cc1ccc(-c2nn3c(C)nnc3c3ccccc23)cc1S(=O)(=O)NC(C)c1ccccc1 nan
CHEMBL1341841 31227 9 None -2 3 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 457 5 1 6 4.6 Cc1ccc(-c2nn3c(C)nnc3c3ccccc23)cc1S(=O)(=O)NC(C)c1ccccc1 nan
9805674 68420 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
ChEMBL 491 9 2 7 5.3 CCCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771261 68420 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
ChEMBL 491 9 2 7 5.3 CCCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
44229547 202042 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 373 7 1 8 3.0 CCc1oc(SCc2cc(N3CCOCC3)cc(NCC#N)n2)nc1C 10.1016/j.bmcl.2009.05.069
CHEMBL551197 202042 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 373 7 1 8 3.0 CCc1oc(SCc2cc(N3CCOCC3)cc(NCC#N)n2)nc1C 10.1016/j.bmcl.2009.05.069
45270796 202398 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 355 7 1 7 2.5 CCc1oc(CCc2cc(N3CCOCC3)cc(NCC#N)n2)nc1C 10.1016/j.bmcl.2009.05.069
CHEMBL556183 202398 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 355 7 1 7 2.5 CCc1oc(CCc2cc(N3CCOCC3)cc(NCC#N)n2)nc1C 10.1016/j.bmcl.2009.05.069
44288023 108080 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 483 10 5 3 3.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H]1CCc2ccccc21 10.1016/s0960-894x(00)00292-4
CHEMBL296523 108080 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 483 10 5 3 3.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H]1CCc2ccccc21 10.1016/s0960-894x(00)00292-4
4876785 50624 7 None -1 2 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 442 5 2 7 2.8 COc1ccc(NC(=O)c2nnc(O)c3ccccc23)cc1S(=O)(=O)N1CCCCC1 nan
CHEMBL1511420 50624 7 None -1 2 Human 4.7 pIC50 = 4.7 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 442 5 2 7 2.8 COc1ccc(NC(=O)c2nnc(O)c3ccccc23)cc1S(=O)(=O)N1CCCCC1 nan
44287730 167836 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 457 11 5 3 3.0 N=C(N)NCCCC(NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL41166 167836 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 457 11 5 3 3.0 N=C(N)NCCCC(NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
11755611 175518 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 497 9 4 3 3.5 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
CHEMBL43710 175518 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 497 9 4 3 3.5 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
44229621 202887 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 369 8 1 7 2.9 CCc1oc(CCc2cc(N3CCOCC3)cc(NCCC#N)n2)nc1C 10.1016/j.bmcl.2009.05.069
CHEMBL560921 202887 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 369 8 1 7 2.9 CCc1oc(CCc2cc(N3CCOCC3)cc(NCCC#N)n2)nc1C 10.1016/j.bmcl.2009.05.069
44288257 175575 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 487 12 6 4 2.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CO)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL43753 175575 0 None - 1 Human 4.7 pIC50 = 4.7 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 487 12 6 4 2.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](CO)c1ccccc1 10.1016/s0960-894x(00)00292-4
647823 61105 8 None -2 3 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 470 9 1 9 4.1 COc1ccccc1CN(Cc1cc2cc(C)ccc2nc1O)Cc1nnnn1Cc1ccco1 nan
CHEMBL1608455 61105 8 None -2 3 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 470 9 1 9 4.1 COc1ccccc1CN(Cc1cc2cc(C)ccc2nc1O)Cc1nnnn1Cc1ccco1 nan
44288137 175010 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 471 11 4 3 3.2 C[C@H](NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL433627 175010 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 471 11 4 3 3.2 C[C@H](NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00292-4
45272520 202542 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 358 7 1 6 3.4 CCc1oc(CCc2cc(N3CCOCC3)cc(NC(C)C)n2)nc1C 10.1016/j.bmcl.2009.05.069
CHEMBL557648 202542 0 None - 1 Human 4.6 pIC50 = 4.6 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 358 7 1 6 3.4 CCc1oc(CCc2cc(N3CCOCC3)cc(NC(C)C)n2)nc1C 10.1016/j.bmcl.2009.05.069
9651051 115896 5 None -1 2 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 334 7 1 6 2.1 CCCCC(=O)N/N=C/c1ccc(N2CCOCC2)c([N+](=O)[O-])c1 nan
CHEMBL3213775 115896 5 None -1 2 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 334 7 1 6 2.1 CCCCC(=O)N/N=C/c1ccc(N2CCOCC2)c([N+](=O)[O-])c1 nan
2330392 28600 7 None - 1 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 286 0 1 3 4.4 Nc1c2c(nc3sc4c(c13)CCCC4)CCCCCC2 nan
CHEMBL1319576 28600 7 None - 1 Human 4.6 pIC50 = 4.6 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 286 0 1 3 4.4 Nc1c2c(nc3sc4c(c13)CCCC4)CCCCCC2 nan
162651924 187134 0 None -56 4 Human 7.6 pIC50 = 7.6 Functional
Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assayAgonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay
ChEMBL 5195 171 80 72 -22.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c01783
CHEMBL4751466 187134 0 None -56 4 Human 7.6 pIC50 = 7.6 Functional
Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assayAgonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay
ChEMBL 5195 171 80 72 -22.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c01783
44517723 201661 0 None 5 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayAntagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay
ChEMBL 581 8 1 4 6.0 COc1ccc([C@H](N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)C(F)F)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL540466 201661 0 None 5 2 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assayAntagonist activity at human neuropeptide Y1 receptor expressed in HEK293 cells by [35S]GTPgammaS binding assay
ChEMBL 581 8 1 4 6.0 COc1ccc([C@H](N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)C(F)F)cc1 10.1016/j.bmcl.2009.06.050
44288067 173140 0 None 57 2 Human 6.6 pIC50 = 6.6 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 513 9 5 4 3.2 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N1CCCc2cc(O)ccc2C1 10.1016/s0960-894x(00)00292-4
CHEMBL42747 173140 0 None 57 2 Human 6.6 pIC50 = 6.6 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 513 9 5 4 3.2 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N1CCCc2cc(O)ccc2C1 10.1016/s0960-894x(00)00292-4
162652708 190439 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 669 15 7 5 3.4 N/C(=N/C(=O)NCCNC(=O)C1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4751668 190439 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 669 15 7 5 3.4 N/C(=N/C(=O)NCCNC(=O)C1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802795 190439 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 669 15 7 5 3.4 N/C(=N/C(=O)NCCNC(=O)C1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44288395 169351 0 None 3 3 Human 5.5 pIC50 = 5.5 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 517 10 5 3 4.0 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N[C@H]1CCc2ccccc21 10.1016/s0960-894x(00)00292-4
CHEMBL41686 169351 0 None 3 3 Human 5.5 pIC50 = 5.5 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 517 10 5 3 4.0 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N[C@H]1CCc2ccccc21 10.1016/s0960-894x(00)00292-4
1454987 56011 6 None -2 2 Human 4.5 pIC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 412 6 1 4 4.6 COc1ccccc1N(CC(=O)NC1CCCC1)C(=O)c1oc(C(C)(C)C)cc1C nan
CHEMBL1562842 56011 6 None -2 2 Human 4.5 pIC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 412 6 1 4 4.6 COc1ccccc1N(CC(=O)NC1CCCC1)C(=O)c1oc(C(C)(C)C)cc1C nan
826220 35317 18 None - 1 Human 4.5 pIC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 289 4 1 2 4.9 O=C(O)c1ccc(N(c2ccccc2)c2ccccc2)cc1 nan
CHEMBL1376342 35317 18 None - 1 Human 4.5 pIC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 289 4 1 2 4.9 O=C(O)c1ccc(N(c2ccccc2)c2ccccc2)cc1 nan
45271626 204444 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 330 6 1 6 2.6 CCc1oc(CCc2cc(N3CCOCC3)cc(NC)n2)nc1C 10.1016/j.bmcl.2009.05.069
CHEMBL571013 204444 0 None - 1 Human 4.5 pIC50 = 4.5 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 330 6 1 6 2.6 CCc1oc(CCc2cc(N3CCOCC3)cc(NC)n2)nc1C 10.1016/j.bmcl.2009.05.069
649706 27266 2 None 2 5 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 420 5 0 7 4.3 CCN(C(=O)c1ccc(C(C)(C)C)cc1)c1nnc(Cn2nnc3ccccc32)s1 nan
CHEMBL1307319 27266 2 None 2 5 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 420 5 0 7 4.3 CCN(C(=O)c1ccc(C(C)(C)C)cc1)c1nnc(Cn2nnc3ccccc32)s1 nan
3200707 61255 2 None - 1 Human 4.5 pIC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 479 7 1 8 3.5 O=C(NC1CCCCC1)C(c1ccncc1)N(Cc1ccc2c(c1)OCO2)C(=O)c1cnsn1 nan
CHEMBL1609697 61255 2 None - 1 Human 4.5 pIC50 = 4.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 479 7 1 8 3.5 O=C(NC1CCCCC1)C(c1ccncc1)N(Cc1ccc2c(c1)OCO2)C(=O)c1cnsn1 nan
3206677 27871 4 None 1 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 351 5 2 3 4.1 Cc1cc2cc(C)c(NCCNC(=O)c3cccc(F)c3)nc2cc1C nan
CHEMBL1312220 27871 4 None 1 2 Human 5.5 pIC50 = 5.5 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 351 5 2 3 4.1 Cc1cc2cc(C)c(NCCNC(=O)c3cccc(F)c3)nc2cc1C nan
4287464 62133 2 None 1 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 351 2 0 1 5.1 Cc1ccc(-[n+]2c(-c3ccccc3)cn3c2CCc2ccccc2-3)c(C)c1 nan
CHEMBL1381600 62133 2 None 1 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 351 2 0 1 5.1 Cc1ccc(-[n+]2c(-c3ccccc3)cn3c2CCc2ccccc2-3)c(C)c1 nan
CHEMBL1619019 62133 2 None 1 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 351 2 0 1 5.1 Cc1ccc(-[n+]2c(-c3ccccc3)cn3c2CCc2ccccc2-3)c(C)c1 nan
44288053 175427 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 458 11 5 4 2.3 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccccn1 10.1016/s0960-894x(00)00292-4
CHEMBL43628 175427 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 458 11 5 4 2.3 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccccn1 10.1016/s0960-894x(00)00292-4
44229544 201864 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 372 6 1 8 2.5 Cc1nc(SCc2cc(N3CCOCC3)cc(NCC#N)n2)n(C)c1C 10.1016/j.bmcl.2009.05.069
CHEMBL549699 201864 0 None - 1 Human 4.4 pIC50 = 4.4 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 372 6 1 8 2.5 Cc1nc(SCc2cc(N3CCOCC3)cc(NCC#N)n2)n(C)c1C 10.1016/j.bmcl.2009.05.069
5708012 31648 12 None 1 3 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 340 5 0 3 5.3 COc1ccc(Cn2c(/C=C/c3ccccc3)nc3ccccc32)cc1 nan
CHEMBL1345334 31648 12 None 1 3 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 340 5 0 3 5.3 COc1ccc(Cn2c(/C=C/c3ccccc3)nc3ccccc32)cc1 nan
5806576 41287 8 None -1 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 373 4 0 5 4.8 N#CC(C#N)=C1C=CC=CN1/C(=C\c1ccco1)C(=O)c1ccc(Cl)cc1 nan
CHEMBL1428935 41287 8 None -1 4 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 373 4 0 5 4.8 N#CC(C#N)=C1C=CC=CN1/C(=C\c1ccco1)C(=O)c1ccc(Cl)cc1 nan
4140078 32622 12 None -2 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 377 4 0 4 4.6 Cc1cccc(-n2ccnc2SCC(=O)N2CCCc3ccccc32)c1C nan
CHEMBL1353428 32622 12 None -2 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 377 4 0 4 4.6 Cc1cccc(-n2ccnc2SCC(=O)N2CCCc3ccccc32)c1C nan
162651402 186961 0 None -338 5 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assayAgonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay
ChEMBL 5221 175 80 73 -23.1 CC[C@H](C)[C@H](NC(=O)C(Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c01783
CHEMBL4749279 186961 0 None -338 5 Human 7.4 pIC50 = 7.4 Functional
Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assayAgonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay
ChEMBL 5221 175 80 73 -23.1 CC[C@H](C)[C@H](NC(=O)C(Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c01783
5740982 38134 7 None 1 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 366 5 0 3 5.1 Cc1ccccc1/C=C/c1nc2ccccc2c(=O)n1CCc1ccccc1 nan
CHEMBL1402158 38134 7 None 1 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 366 5 0 3 5.1 Cc1ccccc1/C=C/c1nc2ccccc2c(=O)n1CCc1ccccc1 nan
45269121 202803 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 398 7 1 6 3.5 CCc1oc(CCc2cc(N3CCOCC3)cc(NCC(F)(F)F)n2)nc1C 10.1016/j.bmcl.2009.05.069
CHEMBL560182 202803 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 398 7 1 6 3.5 CCc1oc(CCc2cc(N3CCOCC3)cc(NCC(F)(F)F)n2)nc1C 10.1016/j.bmcl.2009.05.069
2897425 27946 11 None 1 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 394 9 1 5 4.2 CCN(CC)CC(O)COc1ccc2c(c1)c(C(C)=O)c(C)n2-c1ccccc1 nan
CHEMBL1312713 27946 11 None 1 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 394 9 1 5 4.2 CCN(CC)CC(O)COc1ccc2c(c1)c(C(C)=O)c(C)n2-c1ccccc1 nan
1186757 49632 10 None - 1 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 375 4 1 7 2.1 O=c1c2ccccc2nc2c3ccccc3c(NCCN3CCOCC3)nn12 nan
CHEMBL1502859 49632 10 None - 1 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 375 4 1 7 2.1 O=c1c2ccccc2nc2c3ccccc3c(NCCN3CCOCC3)nn12 nan
1249075 58009 7 None 2 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 429 4 1 4 5.3 CN1CCN(c2ccccc2NC(=O)c2ccc(-c3ccc(Cl)cc3Cl)o2)CC1 nan
CHEMBL1580409 58009 7 None 2 2 Human 5.4 pIC50 = 5.4 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 429 4 1 4 5.3 CN1CCN(c2ccccc2NC(=O)c2ccc(-c3ccc(Cl)cc3Cl)o2)CC1 nan
254021 169894 26 None -3 4 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 223 0 1 3 2.3 Nc1ccc2c(c1)C(=O)C(=O)c1ccccc1-2 nan
CHEMBL417727 169894 26 None -3 4 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 223 0 1 3 2.3 Nc1ccc2c(c1)C(=O)C(=O)c1ccccc1-2 nan
162651028 190430 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 683 16 7 5 3.8 N/C(=N/C(=O)NCCNC(=O)CC1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4750988 190430 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 683 16 7 5 3.8 N/C(=N/C(=O)NCCNC(=O)CC1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802711 190430 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 683 16 7 5 3.8 N/C(=N/C(=O)NCCNC(=O)CC1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
1201829 52669 11 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 437 8 1 5 4.7 COc1cccc(-c2ccc(C#N)c(SCC(=O)NCCc3ccc(Cl)cc3)n2)c1 nan
CHEMBL1531745 52669 11 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 437 8 1 5 4.7 COc1cccc(-c2ccc(C#N)c(SCC(=O)NCCc3ccc(Cl)cc3)n2)c1 nan
44287982 173035 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 500 12 6 4 1.9 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](C(N)=O)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL42686 173035 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 500 12 6 4 1.9 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](C(N)=O)c1ccccc1 10.1016/s0960-894x(00)00292-4
1505224 40123 12 None 3 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 392 5 2 9 2.1 COC(=O)c1ccccc1NC(=O)Cn1c(-c2nonc2N)nc2ccccc21 nan
CHEMBL1419096 40123 12 None 3 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 392 5 2 9 2.1 COC(=O)c1ccccc1NC(=O)Cn1c(-c2nonc2N)nc2ccccc21 nan
4526399 46190 11 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 500 5 0 7 5.1 COC(=O)c1c(C)oc2ccc(N(C(=O)c3ccncc3)S(=O)(=O)c3ccc4ccccc4c3)cc12 nan
CHEMBL1471779 46190 11 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 500 5 0 7 5.1 COC(=O)c1c(C)oc2ccc(N(C(=O)c3ccncc3)S(=O)(=O)c3ccc4ccccc4c3)cc12 nan
1220296 49230 9 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 396 3 1 4 5.2 Cc1ccc(-c2cc(C(=O)Nc3ccc4c(c3)OCCO4)c3ccccc3n2)cc1 nan
CHEMBL1499276 49230 9 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 396 3 1 4 5.2 Cc1ccc(-c2cc(C(=O)Nc3ccc4c(c3)OCCO4)c3ccccc3n2)cc1 nan
9566117 115708 11 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 317 5 2 2 3.4 S=C(NCCc1ccccc1)N/N=C/c1ccccc1Cl nan
CHEMBL3211272 115708 11 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 317 5 2 2 3.4 S=C(NCCc1ccccc1)N/N=C/c1ccccc1Cl nan
2376964 45773 4 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 414 5 1 5 5.3 Nn1c(Cc2cccc3ccccc23)nnc1SCc1c(Cl)cccc1Cl nan
CHEMBL1468302 45773 4 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 414 5 1 5 5.3 Nn1c(Cc2cccc3ccccc23)nnc1SCc1c(Cl)cccc1Cl nan
44288236 173669 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 573 10 4 3 4.7 N=C(N)NCCCC(NC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
CHEMBL42861 173669 0 None - 1 Human 4.3 pIC50 = 4.3 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 573 10 4 3 4.7 N=C(N)NCCCC(NC(=O)C(c1ccccc1)(c1ccccc1)c1ccccc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
831603 58625 17 None -1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 330 5 0 5 4.3 COc1ccc(-c2noc(COc3ccc(Cl)c(C)c3)n2)cc1 nan
CHEMBL1585445 58625 17 None -1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 330 5 0 5 4.3 COc1ccc(-c2noc(COc3ccc(Cl)c(C)c3)n2)cc1 nan
3198 212292 76 None -18 37 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL1201049 212292 76 None -18 37 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
CHEMBL808 212292 76 None -18 37 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 380 6 0 3 5.8 Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1 nan
1302588 62409 8 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 346 8 2 3 4.0 O=C(COc1ccccc1CNCc1ccccc1)Nc1ccccc1 nan
CHEMBL1457093 62409 8 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 346 8 2 3 4.0 O=C(COc1ccccc1CNCc1ccccc1)Nc1ccccc1 nan
CHEMBL1621407 62409 8 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 346 8 2 3 4.0 O=C(COc1ccccc1CNCc1ccccc1)Nc1ccccc1 nan
2609912 55628 6 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 392 5 0 7 4.1 COC(=O)c1ccc(CSc2nc3ccccc3c(=O)n2-c2ccccc2)o1 nan
CHEMBL1559259 55628 6 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 392 5 0 7 4.1 COC(=O)c1ccc(CSc2nc3ccccc3c(=O)n2-c2ccccc2)o1 nan
162648914 190420 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 753 17 7 5 4.7 N/C(=N/C(=O)NCCNC(=O)C(c1ccccc1)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4746354 190420 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 753 17 7 5 4.7 N/C(=N/C(=O)NCCNC(=O)C(c1ccccc1)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802592 190420 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 753 17 7 5 4.7 N/C(=N/C(=O)NCCNC(=O)C(c1ccccc1)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
3706900 41148 8 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 405 7 1 4 3.5 CCC(NCCC(c1ccccc1)c1ccccc1)=C1C(=O)N(C)C(=O)N(C)C1=O nan
CHEMBL1427745 41148 8 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 405 7 1 4 3.5 CCC(NCCC(c1ccccc1)c1ccccc1)=C1C(=O)N(C)C(=O)N(C)C1=O nan
6413289 51625 15 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 372 3 0 3 5.8 Clc1ccc(CSc2cc3c(nn2)-c2ccccc2CC3)cc1Cl nan
CHEMBL1522356 51625 15 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 372 3 0 3 5.8 Clc1ccc(CSc2cc3c(nn2)-c2ccccc2CC3)cc1Cl nan
1183477 27945 16 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 375 4 1 4 4.7 COC(=O)c1cc(Cl)c(NC(=O)c2ccc(C(C)(C)C)cc2)cc1OC nan
CHEMBL1312703 27945 16 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 375 4 1 4 4.7 COC(=O)c1cc(Cl)c(NC(=O)c2ccc(C(C)(C)C)cc2)cc1OC nan
20846851 114855 4 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 398 6 1 4 4.4 O=C(N/N=C/c1ccco1)c1ccccc1OCc1ccc(Br)cc1 nan
CHEMBL3195229 114855 4 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 398 6 1 4 4.4 O=C(N/N=C/c1ccco1)c1ccccc1OCc1ccc(Br)cc1 nan
2181167 61843 4 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 367 7 1 2 5.0 Cc1cc(Cl)c(OCCCNCc2ccccc2)c(Br)c1 nan
CHEMBL1308845 61843 4 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 367 7 1 2 5.0 Cc1cc(Cl)c(OCCCNCc2ccccc2)c(Br)c1 nan
CHEMBL1616638 61843 4 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 367 7 1 2 5.0 Cc1cc(Cl)c(OCCCNCc2ccccc2)c(Br)c1 nan
1477664 53337 21 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 359 5 0 4 5.7 Cc1nc(-c2ccccc2)sc1C(=O)CSc1ccc(Cl)cc1 nan
CHEMBL1537995 53337 21 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 359 5 0 4 5.7 Cc1nc(-c2ccccc2)sc1C(=O)CSc1ccc(Cl)cc1 nan
5338258 56672 5 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 259 3 0 2 4.1 O=C(/C=C/c1cccc2ccccc12)c1ccncc1 nan
CHEMBL1568243 56672 5 None -1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 259 3 0 2 4.1 O=C(/C=C/c1cccc2ccccc12)c1ccncc1 nan
1894428 41567 10 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 388 8 0 7 3.8 CCOc1nc(SCCOc2ccc(Cl)cc2Cl)nc(N(C)C)n1 nan
CHEMBL1431004 41567 10 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 388 8 0 7 3.8 CCOc1nc(SCCOc2ccc(Cl)cc2Cl)nc(N(C)C)n1 nan
665164 61897 5 None 1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 363 7 0 5 3.6 CC(C)COc1ccc(C(=O)OC2CC(C)(C)OCC2CN(C)C)cc1 nan
CHEMBL1348426 61897 5 None 1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 363 7 0 5 3.6 CC(C)COc1ccc(C(=O)OC2CC(C)(C)OCC2CN(C)C)cc1 nan
CHEMBL1617044 61897 5 None 1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 363 7 0 5 3.6 CC(C)COc1ccc(C(=O)OC2CC(C)(C)OCC2CN(C)C)cc1 nan
647568 47758 5 None -1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 335 4 0 6 4.1 CC(C)c1ccc(-c2nnn(Cc3nc4ccccc4s3)n2)cc1 nan
CHEMBL1487131 47758 5 None -1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 335 4 0 6 4.1 CC(C)c1ccc(-c2nnn(Cc3nc4ccccc4s3)n2)cc1 nan
1543852 40691 15 None -1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 371 4 0 4 5.6 N#Cc1ccc(-c2cccnc2)nc1SCc1ccc(Cl)c(Cl)c1 nan
CHEMBL1423799 40691 15 None -1 3 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 371 4 0 4 5.6 N#Cc1ccc(-c2cccnc2)nc1SCc1ccc(Cl)c(Cl)c1 nan
2198291 41121 10 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 401 6 1 2 6.5 O=C(CSCc1c(Cl)cccc1Cl)Nc1ccccc1-c1ccccc1 nan
CHEMBL1427504 41121 10 None 1 2 Human 5.3 pIC50 = 5.3 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 401 6 1 2 6.5 O=C(CSCc1c(Cl)cccc1Cl)Nc1ccccc1-c1ccccc1 nan
2450538 44021 6 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 407 6 1 3 5.8 O=C(COC(=O)c1ccc(-c2ccccc2)cc1)Nc1ccccc1-c1ccccc1 nan
CHEMBL1453672 44021 6 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 407 6 1 3 5.8 O=C(COC(=O)c1ccc(-c2ccccc2)cc1)Nc1ccccc1-c1ccccc1 nan
2385257 48615 5 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 444 7 1 5 5.9 CCc1cccc(CC)c1NC(=O)COC(=O)c1ccccc1-c1nc2ccccc2s1 nan
CHEMBL1493500 48615 5 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 444 7 1 5 5.9 CCc1cccc(CC)c1NC(=O)COC(=O)c1ccccc1-c1nc2ccccc2s1 nan
5281371 41059 15 None -1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 426 5 0 7 4.4 C/C=C(/C)C(=O)O[C@@H]1c2c(ccc3ccc(=O)oc23)O[C@@H]1C(C)(C)OC(=O)/C(C)=C\C nan
CHEMBL1426896 41059 15 None -1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 426 5 0 7 4.4 C/C=C(/C)C(=O)O[C@@H]1c2c(ccc3ccc(=O)oc23)O[C@@H]1C(C)(C)OC(=O)/C(C)=C\C nan
44288112 106984 1 None 2238 2 Human 7.2 pIC50 = 7.2 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 487 11 5 4 2.9 CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
CHEMBL288355 106984 1 None 2238 2 Human 7.2 pIC50 = 7.2 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 487 11 5 4 2.9 CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
826626 61862 10 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 293 4 0 2 5.1 CN(C)Cc1ccccc1Sc1cccc2ccccc12 nan
CHEMBL1310577 61862 10 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 293 4 0 2 5.1 CN(C)Cc1ccccc1Sc1cccc2ccccc12 nan
CHEMBL1616775 61862 10 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 293 4 0 2 5.1 CN(C)Cc1ccccc1Sc1cccc2ccccc12 nan
876519 62363 8 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 345 4 0 2 4.4 Cc1ccc(C(=O)C[n+]2cc(-c3ccccc3)n3c2CCCCC3)cc1 nan
CHEMBL1452153 62363 8 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 345 4 0 2 4.4 Cc1ccc(C(=O)C[n+]2cc(-c3ccccc3)n3c2CCCCC3)cc1 nan
CHEMBL1621027 62363 8 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 345 4 0 2 4.4 Cc1ccc(C(=O)C[n+]2cc(-c3ccccc3)n3c2CCCCC3)cc1 nan
2446403 30455 3 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 391 6 1 3 5.2 O=C(COC(=O)/C=C/c1ccc(Cl)cc1)Nc1ccccc1-c1ccccc1 nan
CHEMBL1335124 30455 3 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 391 6 1 3 5.2 O=C(COC(=O)/C=C/c1ccc(Cl)cc1)Nc1ccccc1-c1ccccc1 nan
1141823 35618 5 None 2 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 422 6 2 4 4.8 Cc1cccc(N=C(S)N(CCN(C)C)Cc2cc3cc(C)cc(C)c3nc2O)c1 nan
CHEMBL1379143 35618 5 None 2 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 422 6 2 4 4.8 Cc1cccc(N=C(S)N(CCN(C)C)Cc2cc3cc(C)cc(C)c3nc2O)c1 nan
9550576 37336 7 None 2 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 458 8 1 5 3.6 Cc1ccccc1C(=O)c1cccn1CC(=O)NCCN1CCN(c2cccc(C)c2C)CC1 nan
CHEMBL1393538 37336 7 None 2 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 458 8 1 5 3.6 Cc1ccccc1C(=O)c1cccn1CC(=O)NCCN1CCN(c2cccc(C)c2C)CC1 nan
6871377 114462 1 None -1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 295 3 1 4 3.7 CC(C)COC(=O)c1cccc2c1-c1ccccc1/C2=N\O nan
CHEMBL3190644 114462 1 None -1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 295 3 1 4 3.7 CC(C)COC(=O)c1cccc2c1-c1ccccc1/C2=N\O nan
714054 29511 9 None 1 4 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 331 4 0 5 4.2 N#Cc1nc(COc2ccc(Cl)cc2)oc1N1CCCCCC1 nan
CHEMBL1327690 29511 9 None 1 4 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 331 4 0 5 4.2 N#Cc1nc(COc2ccc(Cl)cc2)oc1N1CCCCCC1 nan
955150 30609 9 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 335 4 0 3 5.2 O=C(c1ccco1)c1cn(Cc2ccc(Cl)cc2)c2ccccc12 nan
CHEMBL1336318 30609 9 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 335 4 0 3 5.2 O=C(c1ccco1)c1cn(Cc2ccc(Cl)cc2)c2ccccc12 nan
1490113 38734 18 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 446 4 0 4 5.6 Cc1c(OCc2c(F)cccc2Cl)c(=O)ccn1-c1ncc(C(F)(F)F)cc1Cl nan
CHEMBL1407634 38734 18 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 446 4 0 4 5.6 Cc1c(OCc2c(F)cccc2Cl)c(=O)ccn1-c1ncc(C(F)(F)F)cc1Cl nan
1460705 62279 4 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 326 3 1 2 4.4 CC1=CC(C)(C)N(C(=O)CNC2CCCCC2)c2cc(C)ccc21 nan
CHEMBL1414494 62279 4 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 326 3 1 2 4.4 CC1=CC(C)(C)N(C(=O)CNC2CCCCC2)c2cc(C)ccc21 nan
CHEMBL1620238 62279 4 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 326 3 1 2 4.4 CC1=CC(C)(C)N(C(=O)CNC2CCCCC2)c2cc(C)ccc21 nan
2744454 43094 17 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 314 3 1 3 4.7 O=C(Nc1ccc(Cl)cc1)c1csc(-c2ccccc2)n1 nan
CHEMBL1446166 43094 17 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 314 3 1 3 4.7 O=C(Nc1ccc(Cl)cc1)c1csc(-c2ccccc2)n1 nan
2577652 57375 6 None -1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 390 4 0 8 3.5 COC(=O)c1ccc(CSc2nc3sc4c(c3c(=O)n2C)CCCC4)o1 nan
CHEMBL1574689 57375 6 None -1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 390 4 0 8 3.5 COC(=O)c1ccc(CSc2nc3sc4c(c3c(=O)n2C)CCCC4)o1 nan
5854588 61338 11 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 328 5 0 4 5.2 Clc1ccccc1CSc1nnc(/C=C/c2ccccc2)o1 nan
CHEMBL1610409 61338 11 None 1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 328 5 0 4 5.2 Clc1ccccc1CSc1nnc(/C=C/c2ccccc2)o1 nan
4525145 62412 5 None -16 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 365 3 0 3 5.5 CC[n+]1c(/C=C2\SC(c3ccccc3C)=CN2C)sc2ccccc21 nan
6140197 62412 5 None -16 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 365 3 0 3 5.5 CC[n+]1c(/C=C2\SC(c3ccccc3C)=CN2C)sc2ccccc21 nan
73945770 62412 5 None -16 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 365 3 0 3 5.5 CC[n+]1c(/C=C2\SC(c3ccccc3C)=CN2C)sc2ccccc21 nan
CHEMBL1462215 62412 5 None -16 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 365 3 0 3 5.5 CC[n+]1c(/C=C2\SC(c3ccccc3C)=CN2C)sc2ccccc21 nan
CHEMBL1621471 62412 5 None -16 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 365 3 0 3 5.5 CC[n+]1c(/C=C2\SC(c3ccccc3C)=CN2C)sc2ccccc21 nan
9869041 68418 12 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
ChEMBL 463 7 2 7 4.5 COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771259 68418 12 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assayAntagonist activity at NPY Y1 receptor in human SK-N-MC cells assessed as inhibition of NPY-induced calcium mobilization by FLIPR assay
ChEMBL 463 7 2 7 4.5 COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
162654570 190448 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 655 15 7 5 3.0 N/C(=N/C(=O)NCCNC(=O)C1CCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4755079 190448 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 655 15 7 5 3.0 N/C(=N/C(=O)NCCNC(=O)C1CCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802896 190448 0 None - 1 Human 8.1 pIC50 = 8.1 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 655 15 7 5 3.0 N/C(=N/C(=O)NCCNC(=O)C1CCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44229546 203217 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 359 6 1 8 2.8 Cc1nc(SCc2cc(N3CCOCC3)cc(NCC#N)n2)oc1C 10.1016/j.bmcl.2009.05.069
CHEMBL563011 203217 0 None - 1 Human 4.2 pIC50 = 4.2 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 359 6 1 8 2.8 Cc1nc(SCc2cc(N3CCOCC3)cc(NCC#N)n2)oc1C 10.1016/j.bmcl.2009.05.069
6858398 115547 8 None -1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 322 6 0 6 3.1 COc1cc(/C=N/n2cnnc2)ccc1OCc1ccc(C)cc1 nan
CHEMBL3208997 115547 8 None -1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 322 6 0 6 3.1 COc1cc(/C=N/n2cnnc2)ccc1OCc1ccc(C)cc1 nan
9563579 79272 8 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 325 5 0 4 4.7 C/C(=N\OC(=O)c1ccc(OC(C)C)cc1)c1ccc(C)c(C)c1 nan
CHEMBL1990096 79272 8 None 1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 325 5 0 4 4.7 C/C(=N\OC(=O)c1ccc(OC(C)C)cc1)c1ccc(C)c(C)c1 nan
4557532 29666 6 None -1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 434 3 1 5 5.6 Cc1nc(N2CCCCC2)c2c(C)c(C(=O)Nc3ccccc3C(F)(F)F)sc2n1 nan
CHEMBL1328939 29666 6 None -1 2 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 434 3 1 5 5.6 Cc1nc(N2CCCCC2)c2c(C)c(C(=O)Nc3ccccc3C(F)(F)F)sc2n1 nan
649757 54309 16 None -1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 383 3 1 5 5.0 Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1sc2c(c1C#N)CCC2 nan
CHEMBL1545971 54309 16 None -1 3 Human 5.2 pIC50 = 5.2 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 383 3 1 5 5.0 Cc1onc(-c2ccccc2Cl)c1C(=O)Nc1sc2c(c1C#N)CCC2 nan
3235942 47017 7 None 1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 415 4 1 7 3.4 COc1ccc(-n2nc(C(=O)Nc3ccc4c(c3)OCO4)c3ccccc3c2=O)cc1 nan
CHEMBL1480648 47017 7 None 1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 415 4 1 7 3.4 COc1ccc(-n2nc(C(=O)Nc3ccc4c(c3)OCO4)c3ccccc3c2=O)cc1 nan
664856 27412 8 None -1 4 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 281 1 0 4 3.9 Cc1nc(N2CCC(C)CC2)c2oc3ccccc3c2n1 nan
CHEMBL1308461 27412 8 None -1 4 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 281 1 0 4 3.9 Cc1nc(N2CCC(C)CC2)c2oc3ccccc3c2n1 nan
1183030 203500 13 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 394 6 1 4 5.5 Cc1ccc(CCC(=O)Nc2ncc(Cc3cc(Cl)ccc3Cl)s2)o1 nan
CHEMBL564979 203500 13 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 394 6 1 4 5.5 Cc1ccc(CCC(=O)Nc2ncc(Cc3cc(Cl)ccc3Cl)s2)o1 nan
1998473 36481 11 None 2 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 313 6 0 4 3.7 CN(C)CCCSc1nc(-c2ccccc2)nc2c1CCC2 nan
CHEMBL1386511 36481 11 None 2 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 313 6 0 4 3.7 CN(C)CCCSc1nc(-c2ccccc2)nc2c1CCC2 nan
2311088 62424 4 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 387 3 0 2 5.2 COc1ccc(-[n+]2c(-c3ccc(Cl)cc3)cn3c2CCc2ccccc2-3)cc1 nan
CHEMBL1457690 62424 4 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 387 3 0 2 5.2 COc1ccc(-[n+]2c(-c3ccc(Cl)cc3)cn3c2CCc2ccccc2-3)cc1 nan
CHEMBL1621585 62424 4 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 387 3 0 2 5.2 COc1ccc(-[n+]2c(-c3ccc(Cl)cc3)cn3c2CCc2ccccc2-3)cc1 nan
2173045 36135 7 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 346 5 2 3 3.1 Cc1ccc(NC(=O)C(=O)NCCOc2ccc(Cl)cc2)c(C)c1 nan
CHEMBL1383592 36135 7 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 346 5 2 3 3.1 Cc1ccc(NC(=O)C(=O)NCCOc2ccc(Cl)cc2)c(C)c1 nan
972410 62423 10 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 325 4 1 2 4.7 CC(C)(C)NCc1cc(Br)ccc1OC1CCCC1 nan
CHEMBL1458887 62423 10 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 325 4 1 2 4.7 CC(C)(C)NCc1cc(Br)ccc1OC1CCCC1 nan
CHEMBL1621543 62423 10 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 325 4 1 2 4.7 CC(C)(C)NCc1cc(Br)ccc1OC1CCCC1 nan
663290 27780 12 None -3 4 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 426 6 0 6 5.0 Brc1ccc(CSc2nnc(-c3ccccn3)n2Cc2ccco2)cc1 nan
CHEMBL1311570 27780 12 None -3 4 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 426 6 0 6 5.0 Brc1ccc(CSc2nnc(-c3ccccn3)n2Cc2ccco2)cc1 nan
44287924 175266 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 500 12 6 4 1.9 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(N)=O)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL43523 175266 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 500 12 6 4 1.9 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](C(N)=O)c1ccccc1 10.1016/s0960-894x(00)00292-4
44287829 172931 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 497 9 4 3 3.6 N=C(N)NCCCC(NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
CHEMBL42625 172931 0 None - 1 Human 4.1 pIC50 = 4.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 497 9 4 3 3.6 N=C(N)NCCCC(NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCCc2ccccc2C1 10.1016/s0960-894x(00)00292-4
2940376 53483 10 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 496 10 1 8 4.0 COc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCN2CCCCC2)c(OC)c1 nan
CHEMBL1539256 53483 10 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 496 10 1 8 4.0 COc1ccc(NC(=O)CSc2nc3ccccc3c(=O)n2CCCN2CCCCC2)c(OC)c1 nan
5290139 29738 12 None -2 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 496 11 2 10 4.6 CCOC(=O)CCCCC(=O)c1[nH]c(O)nc1CSc1nnc2c3ccccc3n(C(C)C)c2n1 nan
CHEMBL1329549 29738 12 None -2 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 496 11 2 10 4.6 CCOC(=O)CCCCC(=O)c1[nH]c(O)nc1CSc1nnc2c3ccccc3n(C(C)C)c2n1 nan
1798157 34004 12 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 342 5 2 2 4.2 CCCCCC(=O)NC(=S)Nc1ccc(Br)cc1C nan
CHEMBL1366620 34004 12 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 342 5 2 2 4.2 CCCCCC(=O)NC(=S)Nc1ccc(Br)cc1C nan
1235256 36921 13 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 311 1 1 2 5.2 Oc1cccc(-c2nc3ccc4ccccc4c3c3c2CCC3)c1 nan
CHEMBL1389982 36921 13 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 311 1 1 2 5.2 Oc1cccc(-c2nc3ccc4ccccc4c3c3c2CCC3)c1 nan
8178372 60081 2 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 282 3 1 2 4.1 O=C(/C=C/c1cccc(Cl)c1)c1nc2ccccc2[nH]1 nan
CHEMBL1599610 60081 2 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 282 3 1 2 4.1 O=C(/C=C/c1cccc(Cl)c1)c1nc2ccccc2[nH]1 nan
15944687 31375 5 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 370 4 0 6 4.7 COC(=O)c1cc2occc2n1Cc1nc(-c2ccccc2Cl)oc1C nan
CHEMBL1342925 31375 5 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 370 4 0 6 4.7 COC(=O)c1cc2occc2n1Cc1nc(-c2ccccc2Cl)oc1C nan
664816 42423 7 None -2 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 349 6 1 6 4.4 COc1ccc(-c2nc(C#N)c(NC(C)c3ccccc3)o2)cc1OC nan
CHEMBL1439981 42423 7 None -2 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 349 6 1 6 4.4 COc1ccc(-c2nc(C#N)c(NC(C)c3ccccc3)o2)cc1OC nan
2890146 56978 10 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 441 6 1 5 4.9 COc1ccc(-c2[nH]nc3c2C(c2ccc(OC)c(OC)c2)N(c2ccccc2)C3=O)cc1 nan
CHEMBL1570844 56978 10 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 441 6 1 5 4.9 COc1ccc(-c2[nH]nc3c2C(c2ccc(OC)c(OC)c2)N(c2ccccc2)C3=O)cc1 nan
2930337 45803 8 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 331 2 0 3 2.6 O=C1C2CC=C(Cl)CC2C(=O)N1CC1Cc2ccccc2CO1 nan
CHEMBL1468490 45803 8 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 331 2 0 3 2.6 O=C1C2CC=C(Cl)CC2C(=O)N1CC1Cc2ccccc2CO1 nan
101430 103208 19 None -1698 5 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 343 4 4 9 0.2 OC[C@H]1O[C@@H](n2cnc3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O nan
CHEMBL262083 103208 19 None -1698 5 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 343 4 4 9 0.2 OC[C@H]1O[C@@H](n2cnc3c(Nc4ccccc4)ncnc32)[C@H](O)[C@@H]1O nan
44288390 168613 0 None 22 3 Human 7.1 pIC50 = 7.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 491 11 5 3 3.5 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL41457 168613 0 None 22 3 Human 7.1 pIC50 = 7.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 491 11 5 3 3.5 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
44287923 148415 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 516 12 7 5 1.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](C(N)=O)c1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
CHEMBL38531 148415 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 516 12 7 5 1.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](C(N)=O)c1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
162658382 187813 0 None -4 3 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assayAgonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay
ChEMBL 5831 196 92 80 -23.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c01783
CHEMBL4759334 187813 0 None -4 3 Human 7.1 pIC50 = 7.1 Functional
Agonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assayAgonist activity at human NPY1R expressed in HEK293 cells assessed as inhibition of adenosine-induced stimulation of cAMP accumulation by FRET assay
ChEMBL 5831 196 92 80 -23.5 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.0c01783
9590479 115924 8 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 386 6 1 3 5.0 O=C(CSCc1ccc(Cl)cc1)N/N=C/c1c(Cl)cccc1Cl nan
CHEMBL3214137 115924 8 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 386 6 1 3 5.0 O=C(CSCc1ccc(Cl)cc1)N/N=C/c1c(Cl)cccc1Cl nan
2182602 62494 4 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 361 8 0 2 5.0 Cc1ccc(OCCCCN(C)Cc2ccccc2)c(Br)c1 nan
CHEMBL1483730 62494 4 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 361 8 0 2 5.0 Cc1ccc(OCCCCN(C)Cc2ccccc2)c(Br)c1 nan
CHEMBL1622175 62494 4 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 361 8 0 2 5.0 Cc1ccc(OCCCCN(C)Cc2ccccc2)c(Br)c1 nan
2235311 50207 9 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 461 7 0 4 6.4 O=C(CCc1nc(-c2ccccc2)c(-c2ccccc2)o1)OCc1ccc(Br)cc1 nan
CHEMBL1507807 50207 9 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 461 7 0 4 6.4 O=C(CCc1nc(-c2ccccc2)c(-c2ccccc2)o1)OCc1ccc(Br)cc1 nan
650606 56047 12 None 1 4 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 481 8 1 7 4.1 O=C(CN(Cc1ccc2c(c1)OCO2)C(=O)CSc1nc2ccccc2o1)NC1CCCCC1 nan
CHEMBL1563162 56047 12 None 1 4 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 481 8 1 7 4.1 O=C(CN(Cc1ccc2c(c1)OCO2)C(=O)CSc1nc2ccccc2o1)NC1CCCCC1 nan
659248 201151 10 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 258 5 1 2 3.5 CCCCCCn1c2c(c(=N)c3c1CCC3)CCC2 nan
CHEMBL528708 201151 10 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 258 5 1 2 3.5 CCCCCCn1c2c(c(=N)c3c1CCC3)CCC2 nan
CHEMBL530291 201151 10 None -1 3 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 258 5 1 2 3.5 CCCCCCn1c2c(c(=N)c3c1CCC3)CCC2 nan
2313223 62692 2 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 353 3 0 2 4.5 COc1ccccc1-n1c(-c2ccccc2)c[n+]2c1CCc1ccccc1-2 nan
CHEMBL1525599 62692 2 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 353 3 0 2 4.5 COc1ccccc1-n1c(-c2ccccc2)c[n+]2c1CCc1ccccc1-2 nan
CHEMBL1623694 62692 2 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]PUBCHEM_BIOASSAY: Dose response cell-based screening assay for antagonists of neuropeptide Y receptor Y1 (NPY-Y1). (Class of assay: confirmatory) [Related pubchem assays: 1040, 1255, 1254 ]
ChEMBL 353 3 0 2 4.5 COc1ccccc1-n1c(-c2ccccc2)c[n+]2c1CCc1ccccc1-2 nan
943274 50439 9 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 348 2 1 2 5.2 Cc1nc2ccc(F)cc2cc1C(=O)Nc1ccc(Cl)c(Cl)c1 nan
CHEMBL1509886 50439 9 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 348 2 1 2 5.2 Cc1nc2ccc(F)cc2cc1C(=O)Nc1ccc(Cl)c(Cl)c1 nan
6892993 115056 3 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 378 7 1 6 3.8 CCOc1ccc(Oc2c(/C=N/NC(C)=O)c(C)nn2-c2ccccc2)cc1 nan
CHEMBL3197426 115056 3 None -1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 378 7 1 6 3.8 CCOc1ccc(Oc2c(/C=N/NC(C)=O)c(C)nn2-c2ccccc2)cc1 nan
44287971 170221 0 None 165 2 Human 6.1 pIC50 = 6.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 487 12 6 4 2.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](CO)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL41981 170221 0 None 165 2 Human 6.1 pIC50 = 6.1 Functional
NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.NPY Y1-antagonistic activity in HEL cells by measuring the inhibition of porcine NPY (10 nM) stimulated increase in the intracellular [Ca2+] concentration in a FURA-assay.
ChEMBL 487 12 6 4 2.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](CO)c1ccccc1 10.1016/s0960-894x(00)00292-4
45269117 202737 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 358 8 1 6 3.4 CCCNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1 10.1016/j.bmcl.2009.05.069
CHEMBL559593 202737 0 None - 1 Human 5.1 pIC50 = 5.1 Functional
Displacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation countingDisplacement of [125I]PYY from human recombinant NPY Y1 receptor expressed in CHO cells assessed as inhibition of [35S]GTPgammaS binding by scintillation counting
ChEMBL 358 8 1 6 3.4 CCCNc1cc(N2CCOCC2)cc(CCc2nc(C)c(CC)o2)n1 10.1016/j.bmcl.2009.05.069
1481087 36583 16 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 328 4 1 4 4.7 O=C(Nc1ccccc1)OCc1cc(-c2ccccc2Cl)on1 nan
CHEMBL1387309 36583 16 None 1 2 Human 5.1 pIC50 = 5.1 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 328 4 1 4 4.7 O=C(Nc1ccccc1)OCc1cc(-c2ccccc2Cl)on1 nan
1780041 35466 17 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 338 6 0 6 4.0 Clc1ccc(OCCSc2nnnn2C2CCCCC2)cc1 nan
CHEMBL1377743 35466 17 None 1 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 338 6 0 6 4.0 Clc1ccc(OCCSc2nnnn2C2CCCCC2)cc1 nan
2169010 58653 11 None -4 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 377 10 1 4 4.6 COc1ccccc1CCNCc1ccc(OC)c(OCc2ccccc2)c1 nan
CHEMBL1585652 58653 11 None -4 2 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 377 10 1 4 4.6 COc1ccccc1CCNCc1ccc(OC)c(OCc2ccccc2)c1 nan
4246341 33288 4 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 405 4 0 8 3.2 COc1ccc(-c2nnc3sc(C(C)N4C(=O)c5ccccc5C4=O)nn23)cc1 nan
CHEMBL1360426 33288 4 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 405 4 0 8 3.2 COc1ccc(-c2nnc3sc(C(C)N4C(=O)c5ccccc5C4=O)nn23)cc1 nan
2297248 62345 4 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 339 9 0 3 4.9 c1ccc(COc2ccc(OCCCCN3CCCCC3)cc2)cc1 nan
CHEMBL1453832 62345 4 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 339 9 0 3 4.9 c1ccc(COc2ccc(OCCCCN3CCCCC3)cc2)cc1 nan
CHEMBL1620870 62345 4 None - 1 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 339 9 0 3 4.9 c1ccc(COc2ccc(OCCCCN3CCCCC3)cc2)cc1 nan
162661307 190486 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 677 16 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)Cc1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4765023 190486 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 677 16 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)Cc1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803242 190486 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assayAntagonist activity at Y1 receptor in human HEL cells assessed as reduction in pNPY-induced calcium mobilization preincubated for 15 mins followed by pNPY stimulation and measured immediately by Fura-2 dye based fluorescence assay
ChEMBL 677 16 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)Cc1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
665910 52219 7 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 390 2 1 6 3.8 Clc1ccc(C2=Nn3c(nnc3-c3[nH]nc4c3CCC4)SC2)cc1Cl nan
CHEMBL1527817 52219 7 None -1 3 Human 5.0 pIC50 = 5.0 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 390 2 1 6 3.8 Clc1ccc(C2=Nn3c(nnc3-c3[nH]nc4c3CCC4)SC2)cc1Cl nan
972422 60470 10 None 1 2 Human 5.0 pIC50 = 5 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 314 3 2 3 3.9 Cc1ccc(NC(S)=NCc2ccc3c(c2)OCO3)cc1C nan
CHEMBL1603366 60470 10 None 1 2 Human 5.0 pIC50 = 5 Functional
PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]PUBCHEM_BIOASSAY: Dose response counterscreen for neuropeptide Y receptor Y2 (NPY-Y2): Cell-based high throughput assay to measure NPY-Y1 antagonism. (Class of assay: confirmatory) [Related pubchem assays: 1256, 793, 1257 ]
ChEMBL 314 3 2 3 3.9 Cc1ccc(NC(S)=NCc2ccc3c(c2)OCO3)cc1C nan
3081064 207214 12 None - 0 Human 4.4 pKd = 4.4 Functional
pA2 for inhibition of NPY-stimulated [Ca2+] mobilization in HEL cellspA2 for inhibition of NPY-stimulated [Ca2+] mobilization in HEL cells
ChEMBL 398 9 4 3 3.4 N=C(NCCCc1c[nH]cn1)NCCC(c1cc(F)cc(F)c1)c1ccccn1 10.1016/0960-894X(95)00369-5
CHEMBL59832 207214 12 None - 0 Human 4.4 pKd = 4.4 Functional
pA2 for inhibition of NPY-stimulated [Ca2+] mobilization in HEL cellspA2 for inhibition of NPY-stimulated [Ca2+] mobilization in HEL cells
ChEMBL 398 9 4 3 3.4 N=C(NCCCc1c[nH]cn1)NCCC(c1cc(F)cc(F)c1)c1ccccn1 10.1016/0960-894X(95)00369-5
9916525 119148 1 None - 0 Human 8.7 pKi = 8.7 Functional
Ability to reverse Neuropeptide Y receptor type 1-induced inhibition of forskolin-induced inhibition of forskolin-stimulated cAMPAbility to reverse Neuropeptide Y receptor type 1-induced inhibition of forskolin-induced inhibition of forskolin-stimulated cAMP
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC[C@@H]2CCCNC2)c2ccccc12 10.1021/jm970512x
CHEMBL329536 119148 1 None - 0 Human 8.7 pKi = 8.7 Functional
Ability to reverse Neuropeptide Y receptor type 1-induced inhibition of forskolin-induced inhibition of forskolin-stimulated cAMPAbility to reverse Neuropeptide Y receptor type 1-induced inhibition of forskolin-induced inhibition of forskolin-stimulated cAMP
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC[C@@H]2CCCNC2)c2ccccc12 10.1021/jm970512x
CHEMBL187555 73916 0 None - 1 Human 8.7 pKi = 8.7 Functional
Antagonist activity towards Neuropeptide Y receptor type 1Antagonist activity towards Neuropeptide Y receptor type 1
ChEMBL 591 10 4 9 4.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmcl.2004.10.005
10458754 43640 0 None - 0 Human 5.9 pKi = 5.9 Functional
Functional Neuropeptide Y receptor type 1 antagonism was evaluated by its ability to reverse NPY induced inhibition of forskolin-stimulated cyclic AMP production in SK-N-MC cellsFunctional Neuropeptide Y receptor type 1 antagonism was evaluated by its ability to reverse NPY induced inhibition of forskolin-stimulated cyclic AMP production in SK-N-MC cells
ChEMBL 502 8 1 5 5.3 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3CO)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145056 43640 0 None - 0 Human 5.9 pKi = 5.9 Functional
Functional Neuropeptide Y receptor type 1 antagonism was evaluated by its ability to reverse NPY induced inhibition of forskolin-stimulated cyclic AMP production in SK-N-MC cellsFunctional Neuropeptide Y receptor type 1 antagonism was evaluated by its ability to reverse NPY induced inhibition of forskolin-stimulated cyclic AMP production in SK-N-MC cells
ChEMBL 502 8 1 5 5.3 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3CO)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
9982218 108541 6 None - 1 Rat 4.7 pKi = 4.7 Functional
Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with Neuropeptide Y receptor type 1Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with Neuropeptide Y receptor type 1
ChEMBL 471 9 2 5 4.1 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL1435188 108541 6 None - 1 Rat 4.7 pKi = 4.7 Functional
Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with Neuropeptide Y receptor type 1Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with Neuropeptide Y receptor type 1
ChEMBL 471 9 2 5 4.1 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL299879 108541 6 None - 1 Rat 4.7 pKi = 4.7 Functional
Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with Neuropeptide Y receptor type 1Functional response of NPY to inhibit forskolin-stimulated cAMP in cells stably transfected with Neuropeptide Y receptor type 1
ChEMBL 471 9 2 5 4.1 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL187620 73931 0 None - 1 Human 8.4 pKi = 8.4 Functional
Antagonist activity towards Neuropeptide Y receptor type 1Antagonist activity towards Neuropeptide Y receptor type 1
ChEMBL 615 10 4 10 4.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3OC)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
44362574 40747 0 None - 0 Human 5.3 pKi = 5.3 Functional
Functional Neuropeptide Y receptor type 1 antagonism was evaluated by its ability to reverse NPY induced inhibition of forskolin-stimulated cyclic AMP production in SK-N-MC cellsFunctional Neuropeptide Y receptor type 1 antagonism was evaluated by its ability to reverse NPY induced inhibition of forskolin-stimulated cyclic AMP production in SK-N-MC cells
ChEMBL 462 7 0 4 6.4 CN(C)C1CCN(CCc2c(COc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL142427 40747 0 None - 0 Human 5.3 pKi = 5.3 Functional
Functional Neuropeptide Y receptor type 1 antagonism was evaluated by its ability to reverse NPY induced inhibition of forskolin-stimulated cyclic AMP production in SK-N-MC cellsFunctional Neuropeptide Y receptor type 1 antagonism was evaluated by its ability to reverse NPY induced inhibition of forskolin-stimulated cyclic AMP production in SK-N-MC cells
ChEMBL 462 7 0 4 6.4 CN(C)C1CCN(CCc2c(COc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
1545 9082 0 None -70 3 Human 7.1 pEC50 = 7.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 8590988
1504 9583 8 None -16 5 Rat 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
1518 9583 8 None -16 5 Rat 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
1521 9583 8 None -16 5 Rat 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
24868177 9583 8 None -16 5 Rat 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
44288922 9583 8 None -16 5 Rat 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
77068007 9583 8 None -16 5 Rat 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
90479759 9583 8 None -16 5 Rat 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
CHEMBL438945 9583 8 None -16 5 Rat 8.7 pIC50 = 8.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
1528 7417 22 None -1 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 9806339
5311022 7417 22 None -1 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 9806339
CHEMBL1774204 7417 22 None -1 2 Human 9.5 pIC50 = 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 9806339
1522 7124 0 None -158 5 Human 6.0 pIC50 None 6 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 12069595
1508 9664 0 None - 1 Rat 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10694200
155817417 9664 0 None - 1 Rat 6.3 pIC50 None 6.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10694200
1526 9085 0 None -14 5 Rat 7.4 pIC50 None 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10694200
CHEMBL438411 9085 0 None -14 5 Rat 7.4 pIC50 None 7.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10694200
1514 9827 0 None - 1 Rat 8.1 pIC50 None 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10694200
1514 9827 0 None - 1 Rat 8.1 pIC50 None 8.1 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
1545 9082 0 None -4 3 Rat 8.3 pIC50 None 8.3 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
1524 9083 0 None 1 2 Rat 8.4 pIC50 None 8.4 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10694200
1529 8632 0 None 1 2 Rat 9.5 pIC50 None 9.5 Functional
UnclassifiedUnclassified
Guide to Pharmacology None None None None 10694200
1528 7417 22 None 1 2 Rat 9.7 pIC50 None 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 10694200
5311022 7417 22 None 1 2 Rat 9.7 pIC50 None 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 10694200
CHEMBL1774204 7417 22 None 1 2 Rat 9.7 pIC50 None 9.7 Functional
UnclassifiedUnclassified
Guide to Pharmacology 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 10694200


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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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ity		 Common
name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 Assay
Type		 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

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 DOI
4212 205458 82 None - 4 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 444 12 8 10 -0.1 O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 10.1038/s41467-023-40064-9
CHEMBL1417019 205458 82 None - 4 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 444 12 8 10 -0.1 O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 10.1038/s41467-023-40064-9
CHEMBL58 205458 82 None - 4 Human 6.0 pAC50 = 6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 444 12 8 10 -0.1 O=C1c2c(O)ccc(O)c2C(=O)c2c(NCCNCCO)ccc(NCCNCCO)c21 10.1038/s41467-023-40064-9
72093 41835 9 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL1433361 41835 9 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
CHEMBL2103773 41835 9 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 483 16 1 4 6.3 CCCCCCCCOc1ccccc1C(=O)Nc1ccc(C(=O)OCC[N+](C)(CC)CC)cc1 10.1038/s41467-023-40064-9
4413 104849 57 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 347 4 5 4 2.6 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 10.1038/s41467-023-40064-9
CHEMBL273264 104849 57 None - 0 Human 5.0 pAC50 = 5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 347 4 5 4 2.6 N=C(N)Nc1ccc(C(=O)Oc2ccc3cc(C(=N)N)ccc3c2)cc1 10.1038/s41467-023-40064-9
135409453 10545 41 None - 2 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
226 10545 41 None - 2 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
CHEMBL76370 10545 41 None - 2 Human 4.9 pAC50 = 4.9 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 301 7 3 3 2.6 CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N 10.1038/s41467-023-40064-9
2335 18620 22 None - 12 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
8478 18620 22 None - 12 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL1182210 18620 22 None - 12 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
CHEMBL221753 18620 22 None - 12 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 412 11 0 2 6.1 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 10.1038/s41467-023-40064-9
6436173 61890 45 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL1617 61890 45 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 785 2 5 13 6.2 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c5c(nc6cc(C)ccn65)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
41684 37995 105 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
CHEMBL1401 37995 105 None - 0 Human 4.8 pAC50 = 4.8 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 307 4 1 7 2.2 CC(=O)Oc1ccccc1C(=O)Nc1ncc([N+](=O)[O-])s1 10.1038/s41467-023-40064-9
214 10632 58 None - 30 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
2740 10632 58 None - 30 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
5566 10632 58 None - 30 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
66064 10632 58 None - 30 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
CHEMBL422 10632 58 None - 30 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
DB00831 10632 58 None - 30 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 407 4 0 4 4.9 CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F 10.1038/s41467-023-40064-9
5029 22317 92 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C 10.1038/s41467-023-40064-9
CHEMBL1219 22317 92 None - 4 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 359 8 1 5 3.0 COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C 10.1038/s41467-023-40064-9
1016 10519 78 None - 35 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2561 10519 78 None - 35 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2733526 10519 78 None - 35 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
5384 10519 78 None - 35 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL83 10519 78 None - 35 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
DB00675 10519 78 None - 35 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 371 8 0 2 6.0 CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1 10.1038/s41467-023-40064-9
2713 212050 82 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5353524 212050 82 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
5360566 212050 82 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
88536661 212050 82 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
9552079 212050 82 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL1330113 212050 82 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
CHEMBL790 212050 82 None - 0 Human 5.7 pAC50 = 5.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 504 9 10 4 4.2 N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1 10.1038/s41467-023-40064-9
135398735 143746 32 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
136262914 143746 32 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
CHEMBL374478 143746 32 None - 0 Human 4.7 pAC50 = 4.7 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 822 4 6 15 4.3 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C)c(O)c4c(O)c(c(/C=N/N5CCN(C)CC5)c(O)c4c3C2=O)NC(=O)/C(C)=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C 10.1038/s41467-023-40064-9
118422671 9533 65 None - 4 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
1887 9533 65 None - 4 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
71301 9533 65 None - 4 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
7246 9533 65 None - 4 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
CHEMBL434394 9533 65 None - 4 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
DB04861 9533 65 None - 4 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 405 6 3 5 2.4 OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O 10.1038/s41467-023-40064-9
100 10577 58 None - 54 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
2637 10577 58 None - 54 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
5452 10577 58 None - 54 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
CHEMBL479 10577 58 None - 54 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
DB00679 10577 58 None - 54 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 370 4 0 4 5.9 CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1 10.1038/s41467-023-40064-9
3883 190314 112 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
CHEMBL480 190314 112 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 369 5 1 4 3.5 Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1 10.1038/s41467-023-40064-9
216416 118358 48 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
CHEMBL328190 118358 48 None - 0 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 413 6 1 3 5.7 Oc1ccc2c(c1)CC[C@H](c1ccccc1)[C@@H]2c1ccc(OCCN2CCCC2)cc1 10.1038/s41467-023-40064-9
2585 7590 103 None - 22 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
522 7590 103 None - 22 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
551 7590 103 None - 22 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
CHEMBL723 7590 103 None - 22 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
DB01136 7590 103 None - 22 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 406 10 3 5 3.7 COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O 10.1038/s41467-023-40064-9
2600 10551 74 None - 13 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
2608 10551 74 None - 13 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
5405 10551 74 None - 13 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
CHEMBL17157 10551 74 None - 13 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
DB00342 10551 74 None - 13 Human 4.6 pAC50 = 4.6 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 471 8 2 3 6.4 OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O 10.1038/s41467-023-40064-9
2540 11173 111 None - 4 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
CHEMBL1014 11173 111 None - 4 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 610 10 1 11 6.3 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1 10.1038/s41467-023-40064-9
51755 64180 54 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
CHEMBL1651990 64180 54 None - 0 Human 4.5 pAC50 = 4.5 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 454 8 0 4 7.3 Clc1ccc(C(Cn2ccnc2)OCc2ccc(Sc3ccccc3)cc2)c(Cl)c1 10.1038/s41467-023-40064-9
3149 19386 15 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1187011 19386 15 None - 0 Human 5.4 pAC50 = 5.4 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 334 15 0 1 6.1 CCCCCCCCCCCC[N+](C)(C)CCOc1ccccc1 10.1038/s41467-023-40064-9
2327 15614 41 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 257 5 7 7 -1.8 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 10.1038/s41467-023-40064-9
CHEMBL1096979 15614 41 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 257 5 7 7 -1.8 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 10.1038/s41467-023-40064-9
CHEMBL1255778 15614 41 None - 0 Human 5.3 pAC50 = 5.3 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 257 5 7 7 -1.8 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 10.1038/s41467-023-40064-9
5329102 201505 86 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
CHEMBL535 201505 86 None - 0 Human 5.2 pAC50 = 5.2 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 398 7 3 3 3.3 CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C 10.1038/s41467-023-40064-9
11980903 21264 19 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
22526 21264 19 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
5281035 21264 19 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
CHEMBL1201303 21264 19 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 382 4 0 2 5.3 Cc1cc(/C=C/c2ccc3cc(N(C)C)ccc3[n+]2C)c(C)n1-c1ccccc1 10.1038/s41467-023-40064-9
11626560 207716 94 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
CHEMBL601719 207716 94 None - 0 Human 5.1 pAC50 = 5.1 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 449 5 2 6 5.0 C[C@@H](Oc1cc(-c2cnn(C3CCNCC3)c2)cnc1N)c1c(Cl)ccc(F)c1Cl 10.1038/s41467-023-40064-9
2179 174297 76 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 393 5 2 5 4.5 COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
CHEMBL1256655 174297 76 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 393 5 2 5 4.5 COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
CHEMBL43 174297 76 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 393 5 2 5 4.5 COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12 10.1038/s41467-023-40064-9
2194 69857 101 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
CHEMBL178862 69857 101 None - 0 Human 5.0 pAC50 = 5.0 Binding
Binding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assayBinding affinity towards human NPY1R in an in vitro assay with cellular components measured by scintillation proximity assay
ChEMBL 240 2 0 4 4.2 COc1ccc(-c2cc(=S)ss2)cc1 10.1038/s41467-023-40064-9
CHEMBL5271459 200463 0 None - 0 Human 8.6 pEC50 = 8.6 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 5168 150 68 75 -11.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5270985 200445 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 4731 140 64 66 -12.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5277749 200725 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 5106 152 68 70 -12.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5270985 200445 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 4731 140 64 66 -12.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5271459 200463 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 5168 150 68 75 -11.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5277749 200725 0 None - 0 Human 8.5 pEC50 = 8.5 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 5106 152 68 70 -12.7 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5271764 200476 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 4251 131 62 59 -16.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5271764 200476 0 None - 0 Human 8.4 pEC50 = 8.4 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 4251 131 62 59 -16.1 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5285523 201079 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 4254 127 60 57 -13.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5285523 201079 0 None - 0 Human 8.3 pEC50 = 8.3 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 4254 127 60 57 -13.6 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5273099 200528 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 5916 174 76 83 -12.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
CHEMBL5273099 200528 0 None - 0 Human 8.1 pEC50 = 8.1 Binding
Agonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysisAgonist activity at human Y1R expressed in myo-[2-3H]-inositol labelled African green monkey COS7 cells coexpressing chimeric Galphadelta6qi4myr protein assessed as accumulation of [2-3H]-IP after 1 hr by scintillation counting analysis
ChEMBL 5916 174 76 83 -12.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)c1ccc(N(C)Cc2cnc3nc(N)nc(N)c3n2)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.6b00043
1515 9826 0 None - 6 Human 10.7 pIC50 = 10.7 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None None 10.1021/jm000052z
CHEMBL269503 9826 0 None - 6 Human 10.7 pIC50 = 10.7 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None None 10.1021/jm000052z
10008757 195792 0 None 7585 2 Human 10.3 pIC50 = 10.3 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 10.3 pIC50 = 10.3 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10008757 195792 0 None 7585 2 Human 10.3 pIC50 = 10.3 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 10.3 pIC50 = 10.3 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10008757 195792 0 None 7585 2 Human 10.2 pIC50 = 10.2 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 10.2 pIC50 = 10.2 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
1504 9583 8 None -1 10 Human 10.2 pIC50 = 10.2 Binding
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
1518 9583 8 None -1 10 Human 10.2 pIC50 = 10.2 Binding
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
1521 9583 8 None -1 10 Human 10.2 pIC50 = 10.2 Binding
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
24868177 9583 8 None -1 10 Human 10.2 pIC50 = 10.2 Binding
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
44288922 9583 8 None -1 10 Human 10.2 pIC50 = 10.2 Binding
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
77068007 9583 8 None -1 10 Human 10.2 pIC50 = 10.2 Binding
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
90479759 9583 8 None -1 10 Human 10.2 pIC50 = 10.2 Binding
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
CHEMBL438945 9583 8 None -1 10 Human 10.2 pIC50 = 10.2 Binding
Binding affinity to human neuropeptide Y1 receptor by radioligand displacement assayBinding affinity to human neuropeptide Y1 receptor by radioligand displacement assay
ChEMBL None None None None 10.1016/j.bmc.2013.03.016
10030299 195994 0 None - 1 Human 10.0 pIC50 = 10 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 10.0 pIC50 = 10 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041306 143838 0 None - 1 Human 10.0 pIC50 = 10 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 10.0 pIC50 = 10 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 10.0 pIC50 = 10 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.0 pIC50 = 10 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.0 pIC50 = 10 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.0 pIC50 = 10 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 30 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041306 143838 0 None - 1 Human 10.0 pIC50 = 10.0 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 10.0 pIC50 = 10.0 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10030299 195994 0 None - 1 Human 9.9 pIC50 = 9.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 9.9 pIC50 = 9.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10008757 195792 0 None 7585 2 Human 9.9 pIC50 = 9.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.9 pIC50 = 9.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 9.9 pIC50 = 9.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.9 pIC50 = 9.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.9 pIC50 = 9.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.9 pIC50 = 9.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 20 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
45487448 203805 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 473 9 1 8 5.0 CCc1sc(SCc2cc(N3CCOCC3)cc(NCc3cccc(C)n3)n2)nc1CF 10.1016/j.bmcl.2009.07.030
CHEMBL567112 203805 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 473 9 1 8 5.0 CCc1sc(SCc2cc(N3CCOCC3)cc(NCc3cccc(C)n3)n2)nc1CF 10.1016/j.bmcl.2009.07.030
72548703 168346 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]peptide YY from human Y1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]peptide YY from human Y1 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
CHEMBL4128926 168346 0 None - 0 Human 9.9 pIC50 = 9.9 Binding
Displacement of [125I]peptide YY from human Y1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]peptide YY from human Y1 receptor after 120 mins by scintillation counting analysis
ChEMBL 583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12 10.1016/j.bmcl.2018.03.093
1504 9583 8 None -1 10 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
1518 9583 8 None -1 10 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
1521 9583 8 None -1 10 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
24868177 9583 8 None -1 10 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
44288922 9583 8 None -1 10 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
77068007 9583 8 None -1 10 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
90479759 9583 8 None -1 10 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
CHEMBL438945 9583 8 None -1 10 Human 9.9 pIC50 = 9.9 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
127041306 143838 0 None - 1 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10008757 195792 0 None 7585 2 Human 9.8 pIC50 = 9.8 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.8 pIC50 = 9.8 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
45487490 205787 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 441 7 1 8 4.8 Cc1cccc(CNc2cc(N3CCSCC3)cc(CSc3nc(C)c(C)o3)n2)n1 10.1016/j.bmcl.2009.07.030
CHEMBL585669 205787 0 None - 0 Human 9.8 pIC50 = 9.8 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 441 7 1 8 4.8 Cc1cccc(CNc2cc(N3CCSCC3)cc(CSc3nc(C)c(C)o3)n2)n1 10.1016/j.bmcl.2009.07.030
127041306 143838 0 None - 1 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10008757 195792 0 None 7585 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.8 pIC50 = 9.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
91928728 217504 17 None -7 2 Human 9.8 pIC50 = 9.8 Binding
Displacement of radiolabeled NPY from human neuropeptide Y1 receptorDisplacement of radiolabeled NPY from human neuropeptide Y1 receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm8007618
CHEMBL267633 217504 17 None -7 2 Human 9.8 pIC50 = 9.8 Binding
Displacement of radiolabeled NPY from human neuropeptide Y1 receptorDisplacement of radiolabeled NPY from human neuropeptide Y1 receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm8007618
127041327 143909 0 None 1445 3 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3746851 143909 0 None 1445 3 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3747820 143909 0 None 1445 3 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
45487447 205789 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 459 8 1 8 4.8 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(CF)c(C)s3)n2)n1 10.1016/j.bmcl.2009.07.030
CHEMBL585711 205789 0 None - 0 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 459 8 1 8 4.8 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(CF)c(C)s3)n2)n1 10.1016/j.bmcl.2009.07.030
1504 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
1518 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
1521 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
24868177 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
44288922 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
77068007 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
90479759 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
CHEMBL438945 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting methodDisplacement of [125I]peptide YY from Y1 receptor in human SK-N-MC cells measured after 120 mins by scintillation counting method
ChEMBL None None None None 10.1016/j.bmc.2016.11.014
127041327 143909 0 None 1445 3 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3746851 143909 0 None 1445 3 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3747820 143909 0 None 1445 3 Human 9.7 pIC50 = 9.7 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
1504 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
1518 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
1521 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
24868177 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
44288922 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
77068007 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
90479759 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
CHEMBL438945 9583 8 None -1 10 Human 9.7 pIC50 = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
10030299 195994 0 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 9.6 pIC50 = 9.6 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
45487489 203659 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 445 7 1 8 4.7 Cc1nc(SCc2cc(N3CCSCC3)cc(NCc3cccc(F)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL566020 203659 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 445 7 1 8 4.7 Cc1nc(SCc2cc(N3CCSCC3)cc(NCc3cccc(F)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
45487435 203662 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 441 7 1 8 4.6 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(C)s3)n2)n1 10.1016/j.bmcl.2009.07.030
CHEMBL566041 203662 0 None - 0 Human 9.6 pIC50 = 9.6 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 441 7 1 8 4.6 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(C)s3)n2)n1 10.1016/j.bmcl.2009.07.030
127041619 143911 0 None 12302 2 Human 9.5 pIC50 = 9.5 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.5 pIC50 = 9.5 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.5 pIC50 = 9.5 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.5 pIC50 = 9.5 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041306 143838 0 None - 1 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041327 143909 0 None 1445 3 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3746851 143909 0 None 1445 3 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3747820 143909 0 None 1445 3 Human 9.5 pIC50 = 9.5 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
45487524 203804 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 439 8 1 8 4.4 CCc1oc(SCc2cc(N3CCOCC3)cc(NCc3cccc(C)n3)n2)nc1C 10.1016/j.bmcl.2009.07.030
CHEMBL567101 203804 0 None - 0 Human 9.4 pIC50 = 9.4 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 439 8 1 8 4.4 CCc1oc(SCc2cc(N3CCOCC3)cc(NCc3cccc(C)n3)n2)nc1C 10.1016/j.bmcl.2009.07.030
127041619 143911 0 None 12302 2 Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10008757 195792 0 None 7585 2 Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.4 pIC50 = 9.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
45487434 203661 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 451 7 1 8 4.4 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc4c(o3)CCCC4)n2)n1 10.1016/j.bmcl.2009.07.030
CHEMBL566040 203661 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 451 7 1 8 4.4 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc4c(o3)CCCC4)n2)n1 10.1016/j.bmcl.2009.07.030
10030299 195994 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041306 143838 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 9.3 pIC50 = 9.3 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
45487440 203699 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 459 8 1 8 4.8 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(CF)s3)n2)n1 10.1016/j.bmcl.2009.07.030
CHEMBL566255 203699 0 None - 0 Human 9.3 pIC50 = 9.3 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 459 8 1 8 4.8 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(CF)s3)n2)n1 10.1016/j.bmcl.2009.07.030
45487464 203898 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 425 7 1 8 4.1 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(C)o3)n2)n1 10.1016/j.bmcl.2009.07.030
CHEMBL567719 203898 0 None - 0 Human 9.2 pIC50 = 9.2 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 425 7 1 8 4.1 Cc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(C)o3)n2)n1 10.1016/j.bmcl.2009.07.030
10008757 195792 0 None 7585 2 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.2 pIC50 = 9.2 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041327 143909 0 None 1445 3 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3746851 143909 0 None 1445 3 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3747820 143909 0 None 1445 3 Human 9.1 pIC50 = 9.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 2 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
91928728 217504 17 None -7 2 Human 9.0 pIC50 = 9.0 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm801018u
CHEMBL267633 217504 17 None -7 2 Human 9.0 pIC50 = 9.0 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm801018u
1504 9583 8 None -1 10 Human 8.9 pIC50 = 8.9 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None None 10.1021/np900287e
1518 9583 8 None -1 10 Human 8.9 pIC50 = 8.9 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None None 10.1021/np900287e
1521 9583 8 None -1 10 Human 8.9 pIC50 = 8.9 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None None 10.1021/np900287e
24868177 9583 8 None -1 10 Human 8.9 pIC50 = 8.9 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None None 10.1021/np900287e
44288922 9583 8 None -1 10 Human 8.9 pIC50 = 8.9 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None None 10.1021/np900287e
77068007 9583 8 None -1 10 Human 8.9 pIC50 = 8.9 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None None 10.1021/np900287e
90479759 9583 8 None -1 10 Human 8.9 pIC50 = 8.9 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None None 10.1021/np900287e
CHEMBL438945 9583 8 None -1 10 Human 8.9 pIC50 = 8.9 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL None None None None 10.1021/np900287e
10030299 195994 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 8.9 pIC50 = 8.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44294536 195178 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 557 10 2 8 6.3 CCc1sc(CCc2cc(N3CCOCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL50184 195178 0 None - 0 Human 8.9 pIC50 = 8.9 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 557 10 2 8 6.3 CCc1sc(CCc2cc(N3CCOCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
127041306 143838 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
45487522 203940 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 429 7 1 8 4.0 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(F)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL567928 203940 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 429 7 1 8 4.0 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(F)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
127041327 143909 0 None 1445 3 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3746851 143909 0 None 1445 3 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3747820 143909 0 None 1445 3 Human 8.8 pIC50 = 8.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 1 min by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
45487523 203778 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 473 7 1 9 3.5 Cc1cccc(CNc2cc(N3CCS(=O)(=O)CC3)cc(CSc3nc(C)c(C)o3)n2)n1 10.1016/j.bmcl.2009.07.030
CHEMBL566889 203778 0 None - 0 Human 8.8 pIC50 = 8.8 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 473 7 1 9 3.5 Cc1cccc(CNc2cc(N3CCS(=O)(=O)CC3)cc(CSc3nc(C)c(C)o3)n2)n1 10.1016/j.bmcl.2009.07.030
10414488 209458 0 None - 1 Rat 8.8 pIC50 = 8.8 Binding
The compound was tested for the binding affinity against Neuropeptide Y receptor type 1 in ratThe compound was tested for the binding affinity against Neuropeptide Y receptor type 1 in rat
ChEMBL 524 12 1 6 6.3 Clc1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm980521l
CHEMBL61532 209458 0 None - 1 Rat 8.8 pIC50 = 8.8 Binding
The compound was tested for the binding affinity against Neuropeptide Y receptor type 1 in ratThe compound was tested for the binding affinity against Neuropeptide Y receptor type 1 in rat
ChEMBL 524 12 1 6 6.3 Clc1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm980521l
CHEMBL4299523 220354 0 None - 1 Human 8.8 pIC50 = 8.8 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells preincubated with radioligand followed by protein addition for 60 mins by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells preincubated with radioligand followed by protein addition for 60 mins by radioligand binding assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@H](C)CC 10.1021/acs.jmedchem.5b00925
45487445 203941 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 443 8 1 8 4.3 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(CF)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL567941 203941 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 443 8 1 8 4.3 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(CF)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
45487433 203763 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 487 11 1 9 4.3 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(COCCF)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL566664 203763 0 None - 0 Human 8.0 pIC50 = 8 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 487 11 1 9 4.3 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(COCCF)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL188790 74166 0 None - 0 Human 8.0 pIC50 = 8 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 585 9 4 9 4.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
1485 7418 31 None 1 4 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
3474 7418 31 None 1 4 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
5311023 7418 31 None 1 4 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL332347 7418 31 None 1 4 Human 8.0 pIC50 = 8.0 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
44409158 147457 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 523 5 1 5 6.2 CC1(F)CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL381510 147457 0 None - 0 Human 7.0 pIC50 = 7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 523 5 1 5 6.2 CC1(F)CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
44271460 67119 0 None - 0 Human 6.0 pIC50 = 6 Binding
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
ChEMBL 473 13 2 5 7.1 CCCCN(CCCC)CCCNc1nc(Nc2cccc(C(F)(F)F)c2)c2ccccc2n1 10.1016/s0960-894x(00)00177-3
CHEMBL17450 67119 0 None - 0 Human 6.0 pIC50 = 6 Binding
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
ChEMBL 473 13 2 5 7.1 CCCCN(CCCC)CCCNc1nc(Nc2cccc(C(F)(F)F)c2)c2ccccc2n1 10.1016/s0960-894x(00)00177-3
44439436 97299 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 516 5 1 5 5.6 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CC2CCCNC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL238729 97299 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 516 5 1 5 5.6 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CC2CCCNC2)CC1 10.1016/j.bmcl.2006.11.034
16146918 168007 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44342536 168007 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
91931438 168007 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL411800 168007 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44294522 103563 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 556 11 2 7 7.7 CCc1sc(CCc2cc(OC3CCCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL264820 103563 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 556 11 2 7 7.7 CCc1sc(CCc2cc(OC3CCCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
44294698 199906 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 542 11 2 7 7.3 CCc1sc(CCc2cc(OC3CCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL52282 199906 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 542 11 2 7 7.3 CCc1sc(CCc2cc(OC3CCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
44439431 154133 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 530 5 0 5 6.0 CN1CCC(Cn2c3ccccc3c3cc(C(=O)N4CCN(C)CC4)cc(Oc4ccc(Cl)cc4)c32)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL392943 154133 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 530 5 0 5 6.0 CN1CCC(Cn2c3ccccc3c3cc(C(=O)N4CCN(C)CC4)cc(Oc4ccc(Cl)cc4)c32)CC1 10.1016/j.bmcl.2006.11.034
1485 7418 31 None 1 4 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
3474 7418 31 None 1 4 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
5311023 7418 31 None 1 4 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL332347 7418 31 None 1 4 Human 7.9 pIC50 = 7.9 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL441007 220655 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44294538 108409 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 530 11 2 7 7.2 CCc1sc(CCc2cc(OC(C)C)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL298983 108409 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 530 11 2 7 7.2 CCc1sc(CCc2cc(OC(C)C)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL124152 23396 0 None - 1 Human 7.9 pIC50 = 7.9 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 591 10 3 9 4.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmcl.2004.10.005
CHEMBL324990 117288 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 606 10 3 8 6.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(S)=N/CCCN2CCC(c3cccc(OC)c3)CC2)c1 10.1016/s0960-894x(01)00765-x
9894291 82373 2 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 378 5 0 3 5.3 CCOc1cccc([C@]2(N3CCN(c4ccccc4)CC3)CC[C@@H](C)CC2)c1 10.1021/ml200265m
CHEMBL2046864 82373 2 None - 0 Human 6.9 pIC50 = 6.9 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 378 5 0 3 5.3 CCOc1cccc([C@]2(N3CCN(c4ccccc4)CC3)CC[C@@H](C)CC2)c1 10.1021/ml200265m
10052173 64347 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1
ChEMBL 513 6 1 6 4.5 COc1ccc2c(c1)CC(NCC1CCN(C(=O)Cn3c(=O)sc4ccc(Cl)cc43)CC1)CCC2 10.1016/s0960-894x(02)00018-5
CHEMBL166606 64347 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1
ChEMBL 513 6 1 6 4.5 COc1ccc2c(c1)CC(NCC1CCN(C(=O)Cn3c(=O)sc4ccc(Cl)cc43)CC1)CCC2 10.1016/s0960-894x(02)00018-5
44439493 98073 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 479 5 1 4 5.9 CN(C)C(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
CHEMBL240221 98073 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 479 5 1 4 5.9 CN(C)C(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
16144579 173878 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44342730 173878 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
91931426 173878 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL428992 173878 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL268409 217531 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(N)=O)C(c1ccccc1)c1ccccc1)[C@@H](C)O)C(C)C 10.1021/jm000052z
16146919 168459 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CN[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)Cc1ccc(O)cc1 10.1021/jm000052z
44342654 168459 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CN[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)Cc1ccc(O)cc1 10.1021/jm000052z
91931418 168459 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CN[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)Cc1ccc(O)cc1 10.1021/jm000052z
CHEMBL413232 168459 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](CN[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)Cc1ccc(O)cc1 10.1021/jm000052z
21336511 63957 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 476 8 2 3 5.3 O=S(=O)(NC[C@H]1CC[C@@H](CNCC2CCc3ccccc3C2)CC1)c1cccc2ccccc12 10.1016/s0960-894x(02)00002-1
CHEMBL164897 63957 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 476 8 2 3 5.3 O=S(=O)(NC[C@H]1CC[C@@H](CNCC2CCc3ccccc3C2)CC1)c1cccc2ccccc12 10.1016/s0960-894x(02)00002-1
62706261 82378 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 362 4 0 3 4.4 COc1ccccc1[C@@]1(N2CCN(c3ccccc3)CC2)[C@H]2C[C@H](C)C[C@H]21 10.1021/ml200265m
CHEMBL2046869 82378 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 362 4 0 3 4.4 COc1ccccc1[C@@]1(N2CCN(c3ccccc3)CC2)[C@H]2C[C@H](C)C[C@H]21 10.1021/ml200265m
44409205 81803 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 534 7 0 6 5.5 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CCCN3CCCCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL203433 81803 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 534 7 0 6 5.5 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CCCN3CCCCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL115722 16911 0 None - 0 Human 6.9 pIC50 = 6.9 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 583 9 3 8 5.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(S)=N/CCCN2CCN(C3CCCCC3)CC2)c1 10.1016/s0960-894x(01)00765-x
16146061 175736 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CN[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
44342840 175736 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CN[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
91931430 175736 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CN[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
CHEMBL438923 175736 0 None - 0 Human 5.9 pIC50 = 5.9 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CN[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
44439439 97741 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 601 7 0 6 5.4 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CC2CCN(CC(=O)N(C)C)CC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL239568 97741 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 601 7 0 6 5.4 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CC2CCN(CC(=O)N(C)C)CC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL189036 74218 0 None - 0 Human 7.9 pIC50 = 7.9 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 653 9 4 9 5.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3C(F)(F)F)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
44377450 62352 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 521 9 2 5 4.4 COc1ccc2c(c1)CC(NCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL162093 62352 0 None - 0 Human 4.9 pIC50 = 4.9 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 521 9 2 5 4.4 COc1ccc2c(c1)CC(NCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
44287999 169266 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 471 11 4 3 3.2 C[C@@H](NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL41673 169266 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 471 11 4 3 3.2 C[C@@H](NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccccc1 10.1016/s0960-894x(00)00292-4
44377460 59509 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 536 9 2 6 4.3 O=[N+]([O-])c1ccc2c(c1)CC(NCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL159450 59509 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 536 9 2 6 4.3 O=[N+]([O-])c1ccc2c(c1)CC(NCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
16147801 87266 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1989 63 30 26 -7.7 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44342360 87266 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1989 63 30 26 -7.7 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
91931424 87266 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1989 63 30 26 -7.7 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL214707 87266 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1989 63 30 26 -7.7 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44342809 168076 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1989 66 30 26 -7.3 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm000052z
91931442 168076 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1989 66 30 26 -7.3 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm000052z
CHEMBL412257 168076 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1989 66 30 26 -7.3 CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm000052z
44409210 145807 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 521 7 0 6 5.6 O=C1c2c(n(CCCN3CCCCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCOCC1 10.1016/j.bmcl.2005.11.104
CHEMBL378587 145807 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 521 7 0 6 5.6 O=C1c2c(n(CCCN3CCCCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCOCC1 10.1016/j.bmcl.2005.11.104
CHEMBL266021 217452 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm000052z
CHEMBL410792 219620 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
16146329 89255 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CN[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44342802 89255 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CN[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
91931419 89255 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CN[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL217692 89255 0 None - 0 Human 5.8 pIC50 = 5.8 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CN[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44294462 193635 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 544 13 2 7 7.6 CCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
CHEMBL48950 193635 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 544 13 2 7 7.6 CCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
44439430 167998 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 516 5 1 5 5.6 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CC2CCNCC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL411795 167998 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 516 5 1 5 5.6 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CC2CCNCC2)CC1 10.1016/j.bmcl.2006.11.034
1485 7418 31 None 1 4 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
3474 7418 31 None 1 4 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
5311023 7418 31 None 1 4 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL332347 7418 31 None 1 4 Human 7.8 pIC50 = 7.8 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 5 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
44409242 148145 0 None - 1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 538 5 0 6 4.9 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@@H]3CCN(C)C[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL383763 148145 0 None - 1 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 538 5 0 6 4.9 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@@H]3CCN(C)C[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
44294563 108509 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 530 12 2 7 7.2 CCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
CHEMBL299598 108509 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 530 12 2 7 7.2 CCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
44294529 199962 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 556 12 2 7 7.6 CCc1sc(CCc2cc(OCC3(C)CC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL52325 199962 0 None - 0 Human 7.8 pIC50 = 7.8 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 556 12 2 7 7.6 CCc1sc(CCc2cc(OCC3(C)CC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
62706424 82370 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 348 3 1 3 4.1 C[C@H]1C[C@H]2[C@@H](C1)[C@]2(c1ccc(O)cc1)N1CCN(c2ccccc2)CC1 10.1021/ml200265m
CHEMBL2046861 82370 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 348 3 1 3 4.1 C[C@H]1C[C@H]2[C@@H](C1)[C@]2(c1ccc(O)cc1)N1CCN(c2ccccc2)CC1 10.1021/ml200265m
44288390 168613 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 491 11 5 3 3.5 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL41457 168613 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 491 11 5 3 3.5 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)NCc1ccccc1 10.1016/s0960-894x(00)00292-4
44377440 64225 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 551 10 2 6 4.4 COc1cc2c(cc1OC)CC(NCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL165556 64225 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 551 10 2 6 4.4 COc1cc2c(cc1OC)CC(NCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL116864 17295 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 567 9 3 8 4.6 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCN(C3CCCCC3)CC2)c1 10.1016/s0960-894x(01)00765-x
62706426 82372 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 350 3 0 2 4.5 C[C@H]1C[C@H]2[C@@H](C1)[C@]2(c1ccc(F)cc1)N1CCN(c2ccccc2)CC1 10.1021/ml200265m
CHEMBL2046863 82372 0 None - 0 Human 6.8 pIC50 = 6.8 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 350 3 0 2 4.5 C[C@H]1C[C@H]2[C@@H](C1)[C@]2(c1ccc(F)cc1)N1CCN(c2ccccc2)CC1 10.1021/ml200265m
44377461 62353 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 505 8 2 4 4.7 Cc1ccc2c(c1)CC(NCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL162094 62353 0 None - 0 Human 4.8 pIC50 = 4.8 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 505 8 2 4 4.7 Cc1ccc2c(c1)CC(NCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL411200 219650 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm000052z
44287971 170221 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 487 12 6 4 2.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](CO)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL41981 170221 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 487 12 6 4 2.4 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@H](CO)c1ccccc1 10.1016/s0960-894x(00)00292-4
44439437 157533 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 574 6 0 5 6.5 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCN(C3CC3)C[C@@H]2F)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL395640 157533 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 574 6 0 5 6.5 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCN(C3CC3)C[C@@H]2F)CC1 10.1016/j.bmcl.2006.11.034
44409237 147775 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 524 5 1 6 4.6 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@@H]3CCNC[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL382355 147775 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 524 5 1 6 4.6 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@@H]3CCNC[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
44439491 97997 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 562 8 2 5 6.4 CN1CCCC1CCNC(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
CHEMBL240038 97997 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 562 8 2 5 6.4 CN1CCCC1CCNC(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
44409161 172945 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 527 5 1 5 6.1 O=C1c2c(n(CC3CCNCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCC(F)(F)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL426314 172945 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 527 5 1 5 6.1 O=C1c2c(n(CC3CCNCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCC(F)(F)CC1 10.1016/j.bmcl.2005.11.104
45487446 203980 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 473 10 1 9 4.2 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(OCCF)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL568152 203980 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 473 10 1 9 4.2 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccc(OCCF)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
44288112 106984 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 487 11 5 4 2.9 CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
CHEMBL288355 106984 1 None - 0 Human 7.7 pIC50 = 7.7 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 487 11 5 4 2.9 CC(NC(=O)C(CCCN=C(N)N)NC(=O)C(c1ccccc1)c1ccccc1)c1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
62706421 82368 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 347 3 1 3 4.0 C[C@H]1C[C@H]2[C@@H](C1)[C@]2(c1cccc(N)c1)N1CCN(c2ccccc2)CC1 10.1021/ml200265m
CHEMBL2046858 82368 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 347 3 1 3 4.0 C[C@H]1C[C@H]2[C@@H](C1)[C@]2(c1cccc(N)c1)N1CCN(c2ccccc2)CC1 10.1021/ml200265m
44377689 64856 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 521 9 2 5 4.4 COc1ccc2c(c1)CC(NCCN1CCC(CNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL167318 64856 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 521 9 2 5 4.4 COc1ccc2c(c1)CC(NCCN1CCC(CNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
44439444 153706 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 557 5 1 6 6.0 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCn2ccnc2C1 10.1016/j.bmcl.2006.11.034
CHEMBL392583 153706 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 557 5 1 6 6.0 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCn2ccnc2C1 10.1016/j.bmcl.2006.11.034
44439486 98051 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 536 8 1 5 5.8 CN(C)CCN(C)C(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
CHEMBL240208 98051 0 None - 0 Human 6.7 pIC50 = 6.7 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 536 8 1 5 5.8 CN(C)CCN(C)C(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
CHEMBL187555 73916 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 591 10 4 9 4.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3OC)CC2)c1 10.1016/j.bmcl.2004.10.005
CHEMBL188271 74068 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 561 9 4 8 4.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3)CC2)c1 10.1016/j.bmcl.2004.10.005
44396821 134354 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 606 10 4 10 4.4 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3[N+](=O)[O-])CC2)c1 10.1016/j.bmcl.2004.10.005
CHEMBL366340 134354 0 None - 0 Human 8.7 pIC50 = 8.7 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 606 10 4 10 4.4 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3[N+](=O)[O-])CC2)c1 10.1016/j.bmcl.2004.10.005
25181112 185734 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL446342 185734 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470495 185734 0 None - 1 Human 8.7 pIC50 = 8.7 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
127041619 143911 0 None 12302 2 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
1504 9583 8 None -1 10 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
1518 9583 8 None -1 10 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
1521 9583 8 None -1 10 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
24868177 9583 8 None -1 10 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
44288922 9583 8 None -1 10 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
77068007 9583 8 None -1 10 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
90479759 9583 8 None -1 10 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
CHEMBL438945 9583 8 None -1 10 Human 8.6 pIC50 = 8.6 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
1526 9085 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None None 10.1021/jm000052z
CHEMBL438411 9085 0 None - 0 Human 8.6 pIC50 = 8.6 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None None 10.1021/jm000052z
10008757 195792 0 None 7585 2 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 8.6 pIC50 = 8.6 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44294565 193908 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 606 14 2 7 8.4 CCc1sc(CCc2cc(OCCCc3ccccc3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL49177 193908 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 606 14 2 7 8.4 CCc1sc(CCc2cc(OCCCc3ccccc3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
45487511 205502 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 429 7 1 8 4.0 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3ccc(F)nc3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL582790 205502 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 429 7 1 8 4.0 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3ccc(F)nc3)n2)oc1C 10.1016/j.bmcl.2009.07.030
44409121 147983 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 505 5 1 5 6.1 CC1CCN([C@H]2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL382836 147983 0 None - 0 Human 7.7 pIC50 = 7.7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 505 5 1 5 6.1 CC1CCN([C@H]2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
62706260 82377 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 332 3 0 2 4.4 C[C@H]1C[C@H]2[C@@H](C1)[C@]2(c1ccccc1)N1CCN(c2ccccc2)CC1 10.1021/ml200265m
CHEMBL2046868 82377 0 None - 0 Human 5.7 pIC50 = 5.7 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 332 3 0 2 4.4 C[C@H]1C[C@H]2[C@@H](C1)[C@]2(c1ccccc1)N1CCN(c2ccccc2)CC1 10.1021/ml200265m
44377854 126891 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 507 10 2 5 3.8 COc1ccc2c(c1)CC(CNCC1CN(CCNS(=O)(=O)c3cccc4ccccc34)C1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL351082 126891 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 507 10 2 5 3.8 COc1ccc2c(c1)CC(CNCC1CN(CCNS(=O)(=O)c3cccc4ccccc34)C1)CCC2 10.1016/s0960-894x(02)00002-1
44287938 107186 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 631 13 4 4 5.4 N/C(=N/CCCC(NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCCc2cc(O)ccc2C1)NCCCc1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL290175 107186 0 None - 0 Human 4.7 pIC50 = 4.7 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 631 13 4 4 5.4 N/C(=N/CCCC(NC(=O)Cc1ccc(-c2ccccc2)cc1)C(=O)N1CCCc2cc(O)ccc2C1)NCCCc1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL432237 174812 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 565 8 3 9 4.7 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)N1c1cccc(N/C(=N/CCCN2CCC(C(C)(C)C)CC2)NC#N)c1 10.1016/s0960-894x(01)00765-x
CHEMBL411637 219732 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44294671 194861 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 502 10 2 7 6.4 CCc1sc(CCc2cc(OC)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL49795 194861 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 502 10 2 7 6.4 CCc1sc(CCc2cc(OC)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
155512045 176398 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging methodAgonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging method
ChEMBL 1735 55 28 24 -2.7 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC 10.1021/acs.jmedchem.6b00310
CHEMBL4436741 176398 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Agonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging methodAgonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging method
ChEMBL 1735 55 28 24 -2.7 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC 10.1021/acs.jmedchem.6b00310
44294463 182681 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 578 12 2 7 8.0 CCc1sc(CCc2cc(OCc3ccccc3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL45869 182681 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 578 12 2 7 8.0 CCc1sc(CCc2cc(OCc3ccccc3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
44409268 146263 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 524 5 1 6 4.6 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@H]3CCNC[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL379443 146263 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 524 5 1 6 4.6 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@H]3CCNC[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
44287982 173035 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 500 12 6 4 1.9 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](C(N)=O)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL42686 173035 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 500 12 6 4 1.9 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N[C@@H](C(N)=O)c1ccccc1 10.1016/s0960-894x(00)00292-4
CHEMBL187902 73995 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 645 10 4 9 5.4 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3OC(F)(F)F)CC2)c1 10.1016/j.bmcl.2004.10.005
CHEMBL412698 219797 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44409191 176003 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 423 3 0 5 4.2 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL440944 176003 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 423 3 0 5 4.2 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL430274 220395 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](Cc1ccsc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL268351 217528 0 None - 0 Human 4.6 pIC50 = 4.6 Binding
Compound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cellsCompound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C1CCCCC1)C1CCCCC1 10.1016/S0960-894X(00)80696-4
44439489 173837 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 562 8 2 5 6.4 CCN1CCCC1CNC(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
CHEMBL428915 173837 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 562 8 2 5 6.4 CCN1CCCC1CNC(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
73353529 97798 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 378 5 0 5 3.6 CCOc1cccc(C2(N3CCN(c4cnccn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2397200 97798 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 378 5 0 5 3.6 CCOc1cccc(C2(N3CCN(c4cnccn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL114040 16615 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 585 9 3 9 4.9 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)N1c1cccc(N/C(=N/CCCN2CCC(c3ccccc3)CC2)NC#N)c1 10.1016/s0960-894x(01)00765-x
CHEMBL405527 219343 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL412378 219767 0 None - 0 Human 6.6 pIC50 = 6.6 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44439433 97068 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 548 5 0 5 5.9 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCN(C)C[C@@H]2F)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL238517 97068 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 548 5 0 5 5.9 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCN(C)C[C@@H]2F)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL187782 73969 0 None - 0 Human 7.6 pIC50 = 7.6 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 669 10 4 10 5.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3OC(F)(F)F)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
44377722 63969 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 535 10 2 5 4.6 COc1ccc2c(c1)CC(CNCCN1CCC(CNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL164971 63969 0 None - 0 Human 5.6 pIC50 = 5.6 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 535 10 2 5 4.6 COc1ccc2c(c1)CC(CNCCN1CCC(CNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
44439443 97854 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 557 5 2 5 6.1 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCc2[nH]cnc2C1 10.1016/j.bmcl.2006.11.034
CHEMBL239775 97854 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 557 5 2 5 6.1 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCc2[nH]cnc2C1 10.1016/j.bmcl.2006.11.034
44294503 194350 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 570 11 2 7 8.1 CCc1sc(CCc2cc(OC3CCCCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL49461 194350 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 570 11 2 7 8.1 CCc1sc(CCc2cc(OC3CCCCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
44377452 126937 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 521 9 2 5 4.4 COc1ccc2c(c1)CC(CNC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL351508 126937 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 521 9 2 5 4.4 COc1ccc2c(c1)CC(CNC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL187399 73882 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 586 9 4 9 4.4 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3C#N)CC2)c1 10.1016/j.bmcl.2004.10.005
CHEMBL187925 74001 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 631 10 4 10 4.9 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3SC)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
CHEMBL189412 74268 0 None - 0 Human 8.5 pIC50 = 8.5 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 610 9 4 10 4.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3C#N)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
91928728 217504 17 None -7 2 Human 8.5 pIC50 = 8.5 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm000052z
CHEMBL267633 217504 17 None -7 2 Human 8.5 pIC50 = 8.5 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm000052z
1485 7418 31 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
3474 7418 31 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
5311023 7418 31 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
CHEMBL332347 7418 31 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
1485 7418 31 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
3474 7418 31 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
5311023 7418 31 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL332347 7418 31 None 1 4 Human 8.4 pIC50 = 8.4 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cellsDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
44294383 193549 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 592 13 2 7 8.0 CCc1sc(CCc2cc(OCCc3ccccc3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL48897 193549 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 592 13 2 7 8.0 CCc1sc(CCc2cc(OCCc3ccccc3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
62706262 82379 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 362 4 0 3 4.4 COc1cccc([C@@]2(N3CCN(c4ccccc4)CC3)[C@H]3C[C@H](C)C[C@H]32)c1 10.1021/ml200265m
CHEMBL2046870 82379 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 362 4 0 3 4.4 COc1cccc([C@@]2(N3CCN(c4ccccc4)CC3)[C@H]3C[C@H](C)C[C@H]32)c1 10.1021/ml200265m
CHEMBL187492 73904 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 629 9 4 8 5.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3C(F)(F)F)CC2)c1 10.1016/j.bmcl.2004.10.005
44294672 193630 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 516 11 2 7 6.8 CCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
CHEMBL48947 193630 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 516 11 2 7 6.8 CCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
44409177 172607 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 520 5 0 6 5.0 CN1CCC(Cn2c3c(c4ccccc42)C(=O)C(N2CCN(C)CC2)C[C@H]3Oc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL424862 172607 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 520 5 0 6 5.0 CN1CCC(Cn2c3c(c4ccccc42)C(=O)C(N2CCN(C)CC2)C[C@H]3Oc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2005.11.104
44409330 83535 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 520 7 1 6 5.2 O=C1c2c(n(CCCN3CCCCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCNCC1 10.1016/j.bmcl.2005.11.104
CHEMBL206799 83535 0 None - 0 Human 6.5 pIC50 = 6.5 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 520 7 1 6 5.2 O=C1c2c(n(CCCN3CCCCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCNCC1 10.1016/j.bmcl.2005.11.104
44409236 82344 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 519 7 0 5 6.7 O=C1c2c(n(CCCN3CCCCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCCCC1 10.1016/j.bmcl.2005.11.104
CHEMBL204583 82344 0 None - 0 Human 5.5 pIC50 = 5.5 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 519 7 0 5 6.7 O=C1c2c(n(CCCN3CCCCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCCCC1 10.1016/j.bmcl.2005.11.104
44294315 191155 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 558 14 2 7 8.0 CCCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
CHEMBL48456 191155 0 None - 0 Human 7.5 pIC50 = 7.5 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 558 14 2 7 8.0 CCCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
CHEMBL266077 217454 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Compound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cellsCompound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1016/S0960-894X(00)80696-4
44377731 64216 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 507 8 2 5 4.1 COc1ccc2c(c1)CC(NC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL165506 64216 0 None - 0 Human 4.5 pIC50 = 4.5 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 507 8 2 5 4.1 COc1ccc2c(c1)CC(NC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
155524657 177768 0 None -794 4 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging methodAgonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging method
ChEMBL 1705 55 30 22 -4.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)CCCC[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00310
CHEMBL4456247 177768 0 None -794 4 Human 6.4 pIC50 = 6.4 Binding
Agonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging methodAgonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging method
ChEMBL 1705 55 30 22 -4.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)CCCC[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00310
44409367 147104 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 536 7 2 7 4.0 O=C1c2c(n(CC3CCNCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCN(CCO)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL380654 147104 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 536 7 2 7 4.0 O=C1c2c(n(CC3CCNCC3)c3ccccc23)[C@H](Oc2ccc(Cl)cc2)CC1N1CCN(CCO)CC1 10.1016/j.bmcl.2005.11.104
44409173 81802 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 520 5 1 6 4.1 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1=O 10.1016/j.bmcl.2005.11.104
CHEMBL203430 81802 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 520 5 1 6 4.1 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1=O 10.1016/j.bmcl.2005.11.104
CHEMBL414482 219912 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Compound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cellsCompound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C1CCCCC1 10.1016/S0960-894X(00)80696-4
CHEMBL189548 74289 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 615 10 3 10 4.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCCN2CCN(c3cccc(OC)c3)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
9931301 208668 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
The compound was tested for the binding affinity against Neuropeptide Y receptor type 1The compound was tested for the binding affinity against Neuropeptide Y receptor type 1
ChEMBL 408 7 0 4 5.3 CC[C@H]1CC[C@@](c2cccc(OCOC)c2)(N2CCN(c3ccccc3)CC2)CC1 10.1021/jm980521l
CHEMBL60737 208668 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
The compound was tested for the binding affinity against Neuropeptide Y receptor type 1The compound was tested for the binding affinity against Neuropeptide Y receptor type 1
ChEMBL 408 7 0 4 5.3 CC[C@H]1CC[C@@](c2cccc(OCOC)c2)(N2CCN(c3ccccc3)CC2)CC1 10.1021/jm980521l
CHEMBL410938 219630 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL187491 73903 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 575 9 4 8 4.8 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3C)CC2)c1 10.1016/j.bmcl.2004.10.005
CHEMBL187620 73931 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 615 10 4 10 4.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3OC)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
44396885 74126 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 630 10 4 11 4.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3[N+](=O)[O-])CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
CHEMBL188576 74126 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 630 10 4 11 4.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3[N+](=O)[O-])CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
CHEMBL361273 129948 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 599 9 4 9 4.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3C)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
CHEMBL324554 117204 0 None - 1 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against Neuropeptide Y receptor type 1 using I-PYY as a radioligand in human neuroblastoma SK-N-MC cellsBinding affinity against Neuropeptide Y receptor type 1 using I-PYY as a radioligand in human neuroblastoma SK-N-MC cells
ChEMBL 590 10 3 8 5.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3cccc(OC)c3)CC2)c1 10.1016/s0960-894x(01)00765-x
127041327 143909 0 None 1445 3 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3746851 143909 0 None 1445 3 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3747820 143909 0 None 1445 3 Human 8.4 pIC50 = 8.4 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 10 nM pNPY-induced Ca+2 response preincubated for 10 secs by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
45487432 203762 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 455 9 1 9 4.0 COCc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(C)o3)n2)n1 10.1016/j.bmcl.2009.07.030
CHEMBL566663 203762 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 455 9 1 9 4.0 COCc1cccc(CNc2cc(N3CCOCC3)cc(CSc3nc(C)c(C)o3)n2)n1 10.1016/j.bmcl.2009.07.030
10053818 199320 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 572 11 2 8 7.0 CCc1sc(CCc2cc(OC3CCOCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL52108 199320 0 None - 0 Human 8.4 pIC50 = 8.4 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 572 11 2 8 7.0 CCc1sc(CCc2cc(OC3CCOCC3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
71456264 86270 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 570 14 2 7 8.2 CC/C=C\CCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
CHEMBL2113710 86270 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 570 14 2 7 8.2 CC/C=C\CCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
101835328 7491 41 None - 5 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
16133800 7491 41 None - 5 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
16201612 7491 41 None - 5 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
616 7491 41 None - 5 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
91898967 7491 41 None - 5 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
CHEMBL437027 7491 41 None - 5 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
DB11724 7491 41 None - 5 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cellsDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells
ChEMBL None None None None 10.1016/j.bmcl.2012.11.110
72714999 97799 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 377 5 0 4 4.2 CCOc1cccc(C2(N3CCN(c4ccccn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2397201 97799 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 377 5 0 4 4.2 CCOc1cccc(C2(N3CCN(c4ccccn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
73353531 97801 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 379 5 0 6 3.0 CCOc1cccc(C2(N3CCN(c4ncncn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2397293 97801 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 379 5 0 6 3.0 CCOc1cccc(C2(N3CCN(c4ncncn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
44439438 175667 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 532 5 1 5 5.8 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CC2=C(F)CNCC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL438342 175667 0 None - 0 Human 7.4 pIC50 = 7.4 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 532 5 1 5 5.8 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CC2=C(F)CNCC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL331578 120098 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 568 9 3 9 4.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)N1c1cccc(NC(=O)NCCCN2CCN(C3CCCCC3)CC2)c1 10.1016/s0960-894x(01)00765-x
44409234 147688 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 538 5 0 6 4.9 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@H]3CCN(C)C[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL382204 147688 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 538 5 0 6 4.9 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@H]3CCN(C)C[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
73350550 97802 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 378 5 0 5 3.6 CCOc1cccc(C2(N3CCN(c4cccnn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2397294 97802 0 None - 0 Human 5.4 pIC50 = 5.4 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 378 5 0 5 3.6 CCOc1cccc(C2(N3CCN(c4cccnn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL415176 219956 0 None - 0 Human 4.4 pIC50 = 4.4 Binding
Compound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cellsCompound was evaluated for its inhibitory activity against human neuropeptide Y1 receptor expressing SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC)C1CCCCC1 10.1016/S0960-894X(00)80696-4
CHEMBL262221 217312 0 None - 0 Human 6.4 pIC50 = 6.4 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)C(c1ccccc1)c1ccccc1 10.1021/jm000052z
62706423 82369 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 346 3 0 2 4.7 Cc1ccc([C@@]2(N3CCN(c4ccccc4)CC3)[C@H]3C[C@H](C)C[C@H]32)cc1 10.1021/ml200265m
CHEMBL2046860 82369 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 346 3 0 2 4.7 Cc1ccc([C@@]2(N3CCN(c4ccccc4)CC3)[C@H]3C[C@H](C)C[C@H]32)cc1 10.1021/ml200265m
44439456 97340 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 548 6 1 5 6.0 CN(C)C1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCNC[C@H]2F)C1 10.1016/j.bmcl.2006.11.034
CHEMBL238736 97340 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 548 6 1 5 6.0 CN(C)C1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCNC[C@H]2F)C1 10.1016/j.bmcl.2006.11.034
CHEMBL2111764 215997 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL427594 220132 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
44409345 175820 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 506 5 1 6 4.6 CN1CCN([C@H]2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL439506 175820 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 506 5 1 6 4.6 CN1CCN([C@H]2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
155517347 176976 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Agonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging methodAgonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging method
ChEMBL 1703 54 30 22 -4.3 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C/C=C\C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00310
CHEMBL4445077 176976 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Agonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging methodAgonist activity at GFP-tagged neuropeptide Y1R (unknown origin) expressed in HEK293T cells assessed as beta-arrestin2 recruitment measured after 60 mins by H33342 staining-based imaging method
ChEMBL 1703 54 30 22 -4.3 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)C/C=C\C[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00310
CHEMBL362083 130447 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 607 10 4 9 5.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3SC)CC2)c1 10.1016/j.bmcl.2004.10.005
CHEMBL364380 131823 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 601 9 5 10 3.9 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3ccccc3O)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
45487514 205726 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 429 7 1 8 4.0 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3ccnc(F)c3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL584908 205726 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 429 7 1 8 4.0 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3ccnc(F)c3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL113935 16597 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 584 9 3 8 5.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCCN2CCC(c3ccccc3)CC2)NC#N)c1 10.1016/s0960-894x(01)00765-x
11757487 196151 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 558 13 2 7 8.0 CCc1sc(CCc2cc(OC(CC)CC)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL51284 196151 0 None - 0 Human 8.3 pIC50 = 8.3 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 558 13 2 7 8.0 CCc1sc(CCc2cc(OC(CC)CC)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
21129772 176203 4 None -2 9 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
CHEMBL44246 176203 4 None -2 9 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/s0960-894x(00)00292-4
44439440 97852 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 544 7 0 5 6.5 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CCCN2CCCCC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL239773 97852 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 544 7 0 5 6.5 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3CCCN2CCCCC2)CC1 10.1016/j.bmcl.2006.11.034
44439485 161175 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 522 8 2 5 5.5 CN(C)CCNC(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
CHEMBL398782 161175 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 522 8 2 5 5.5 CN(C)CCNC(=O)c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F 10.1016/j.bmcl.2006.11.034
73348990 97804 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 378 5 0 5 3.6 CCOc1cccc(C2(N3CCN(c4cncnc4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2397296 97804 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 378 5 0 5 3.6 CCOc1cccc(C2(N3CCN(c4cncnc4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
44439432 98308 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 534 5 1 5 5.6 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCNC[C@@H]2F)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL240404 98308 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 534 5 1 5 5.6 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCNC[C@@H]2F)CC1 10.1016/j.bmcl.2006.11.034
44439434 153943 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 534 5 1 5 5.6 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCNC[C@H]2F)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL392787 153943 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 534 5 1 5 5.6 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCNC[C@H]2F)CC1 10.1016/j.bmcl.2006.11.034
44288395 169351 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 517 10 5 3 4.0 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N[C@H]1CCc2ccccc21 10.1016/s0960-894x(00)00292-4
CHEMBL41686 169351 0 None - 0 Human 5.3 pIC50 = 5.3 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 517 10 5 3 4.0 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccc(Cl)cc1)C(=O)N[C@H]1CCc2ccccc21 10.1016/s0960-894x(00)00292-4
72715000 97800 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 378 5 0 5 3.6 CCOc1cccc(C2(N3CCN(c4ncccn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2397291 97800 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 378 5 0 5 3.6 CCOc1cccc(C2(N3CCN(c4ncccn4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
44294516 171781 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 558 11 2 7 7.8 CCc1sc(CCc2cc(OCC(C)(C)C)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL422583 171781 0 None - 0 Human 7.3 pIC50 = 7.3 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 558 11 2 7 7.8 CCc1sc(CCc2cc(OCC(C)(C)C)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
62706425 82371 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 362 4 0 3 4.4 COc1ccc([C@@]2(N3CCN(c4ccccc4)CC3)[C@H]3C[C@H](C)C[C@H]32)cc1 10.1021/ml200265m
CHEMBL2046862 82371 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 362 4 0 3 4.4 COc1ccc([C@@]2(N3CCN(c4ccccc4)CC3)[C@H]3C[C@H](C)C[C@H]32)cc1 10.1021/ml200265m
CHEMBL116230 17151 0 None - 0 Human 6.3 pIC50 = 6.3 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 591 10 3 9 5.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)N1c1cccc(NC(=O)NCCCN2CCC(c3cccc(OC)c3)CC2)c1 10.1016/s0960-894x(01)00765-x
CHEMBL360205 129378 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 577 9 5 9 4.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3ccccc3O)CC2)c1 10.1016/j.bmcl.2004.10.005
44294564 196160 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 607 14 2 8 7.8 CCc1sc(CCc2cc(OCCCc3cccnc3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL51290 196160 0 None - 0 Human 8.2 pIC50 = 8.2 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 607 14 2 8 7.8 CCc1sc(CCc2cc(OCCCc3cccnc3)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
20556258 70539 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
ChEMBL 419 4 1 7 2.9 COc1cc2nc(N3CCC(N4Cc5ccccc5C4=O)CC3)nc(N)c2cc1OC 10.1016/s0960-894x(00)00177-3
CHEMBL18016 70539 0 None - 0 Human 4.2 pIC50 = 4.2 Binding
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
ChEMBL 419 4 1 7 2.9 COc1cc2nc(N3CCC(N4Cc5ccccc5C4=O)CC3)nc(N)c2cc1OC 10.1016/s0960-894x(00)00177-3
73353533 97805 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 376 5 0 3 4.8 CCOc1cccc(C2(N3CCN(c4ccccc4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2397299 97805 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 376 5 0 3 4.8 CCOc1cccc(C2(N3CCN(c4ccccc4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
57384007 82376 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 376 5 0 3 4.8 CCOc1cccc([C@@]2(N3CCN(c4ccccc4)CC3)[C@H]3C[C@H](C)C[C@H]32)c1 10.1021/ml200265m
CHEMBL2046867 82376 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 376 5 0 3 4.8 CCOc1cccc([C@@]2(N3CCN(c4ccccc4)CC3)[C@H]3C[C@H](C)C[C@H]32)c1 10.1021/ml200265m
44294543 196317 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 572 15 2 7 8.4 CCCCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
CHEMBL51422 196317 0 None - 0 Human 7.2 pIC50 = 7.2 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 572 15 2 7 8.4 CCCCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
44409307 83515 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 533 7 0 5 7.0 CC1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CCCN3CCCCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL206671 83515 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 533 7 0 5 7.0 CC1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CCCN3CCCCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
44288067 173140 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 513 9 5 4 3.2 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N1CCCc2cc(O)ccc2C1 10.1016/s0960-894x(00)00292-4
CHEMBL42747 173140 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Inhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cellsInhibition of binding of [3H]propionyl-NPY (1 nM) to Neuropeptide Y receptor type 1 in SK-N-MC cells
ChEMBL 513 9 5 4 3.2 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)N1CCCc2cc(O)ccc2C1 10.1016/s0960-894x(00)00292-4
CHEMBL425095 220109 0 None - 0 Human 6.2 pIC50 = 6.2 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
127041619 143911 0 None 12302 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
45487512 203895 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 429 7 1 8 4.0 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccnc3F)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL567708 203895 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 429 7 1 8 4.0 Cc1nc(SCc2cc(N3CCOCC3)cc(NCc3cccnc3F)n2)oc1C 10.1016/j.bmcl.2009.07.030
44294626 191401 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 586 16 2 7 8.8 CCCCCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
CHEMBL48493 191401 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 586 16 2 7 8.8 CCCCCCCOc1cc(CCc2nc(C)c(CC)s2)nc(NCc2cc(Cl)cc(NC(=O)OC(C)C)c2)c1 10.1016/j.bmcl.2004.01.049
44409209 83316 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 436 6 0 4 6.3 O=C1CC[C@@H](Oc2ccc(Cl)cc2)c2c1c1ccccc1n2CCCN1CCCCC1 10.1016/j.bmcl.2005.11.104
CHEMBL206112 83316 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 436 6 0 4 6.3 O=C1CC[C@@H](Oc2ccc(Cl)cc2)c2c1c1ccccc1n2CCCN1CCCCC1 10.1016/j.bmcl.2005.11.104
16146616 173499 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
44342628 173499 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
91931428 173499 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
CHEMBL428292 173499 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](CN[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
CHEMBL2314835 216287 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Binding affinity to Y1 receptor in human SK-N-MC cellsBinding affinity to Y1 receptor in human SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)[C@H](CCCCNC(=O)COCC(=O)NCCOCCOCC(=O)NCC(=O)Nc1ccc(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)cc1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1016/j.bmcl.2012.11.110
CHEMBL428320 220215 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL438935 220593 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
CHEMBL413612 219856 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
16148366 176133 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CN[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
44342930 176133 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CN[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
91931417 176133 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CN[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
CHEMBL441936 176133 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL 1916 63 29 26 -8.4 CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](CN[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C)CC(C)C 10.1021/jm000052z
44409363 83523 1 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 506 5 1 6 4.6 CN1CCN([C@@H]2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL206723 83523 1 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 506 5 1 6 4.6 CN1CCN([C@@H]2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
44439445 97072 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 535 5 2 5 5.8 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCC(O)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL238527 97072 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 535 5 2 5 5.8 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCC(O)CC1 10.1016/j.bmcl.2006.11.034
10030299 195994 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
45487501 203733 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 477 7 1 9 3.4 Cc1nc(SCc2cc(N3CCS(=O)(=O)CC3)cc(NCc3cccc(F)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL566441 203733 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Displacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation countingDisplacement of [125I]-PYY from human NPYY1 receptor overexpressed in CHO cell membrane after 120 mins by scintillation counting
ChEMBL 477 7 1 9 3.4 Cc1nc(SCc2cc(N3CCS(=O)(=O)CC3)cc(NCc3cccc(F)n3)n2)oc1C 10.1016/j.bmcl.2009.07.030
CHEMBL187490 73902 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 619 9 4 9 4.9 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(N/C(=N/CCNC2CCN(c3cccc(Cl)c3)CC2)NC#N)c1 10.1016/j.bmcl.2004.10.005
CHEMBL360188 129356 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Inhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptorsInhibition of binding of [125I]PYY to membranes of SK-N-MC cells expressing the human Y1 receptors
ChEMBL 595 9 4 8 5.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCNC2CCN(c3cccc(Cl)c3)CC2)c1 10.1016/j.bmcl.2004.10.005
10008757 195792 0 None 7585 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 8.1 pIC50 = 8.1 Binding
Antagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysisAntagonist activity at NPY1R in human HEL cells assessed as inhibition of 300 nM pNPY-induced Ca+2 response preincubated for 15 mins by Fura-2 dye based spectrofluorimetric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44294458 169927 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 560 13 2 8 6.8 CCc1sc(CCc2cc(OC(C)COC)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
CHEMBL417912 169927 0 None - 0 Human 8.1 pIC50 = 8.1 Binding
Binding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYYBinding affinity against human recombinant NPY Y1 receptor in CHO/dhFr- cell membranes using [125I]PYY
ChEMBL 560 13 2 8 6.8 CCc1sc(CCc2cc(OC(C)COC)cc(NCc3cc(Cl)cc(NC(=O)OC(C)C)c3)n2)nc1C 10.1016/j.bmcl.2004.01.049
1485 7418 31 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/np900287e
3474 7418 31 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/np900287e
5311023 7418 31 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/np900287e
CHEMBL332347 7418 31 None 1 4 Human 8.1 pIC50 = 8.1 Binding
Inhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation countingInhibition of neuropeptide Y1 receptor in human SK-N-MC cells after 60 mins by scintillation counting
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/np900287e
CHEMBL2314835 216287 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)[C@H](CCCCNC(=O)COCC(=O)NCCOCCOCC(=O)NCC(=O)Nc1ccc(C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)cc1)NC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1016/j.bmcl.2012.11.110
44271463 67105 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
ChEMBL 307 6 3 5 3.0 NCCCCNc1nc(N)c2cc(-c3ccccc3)ccc2n1 10.1016/s0960-894x(00)00177-3
CHEMBL17441 67105 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
ChEMBL 307 6 3 5 3.0 NCCCCNc1nc(N)c2cc(-c3ccccc3)ccc2n1 10.1016/s0960-894x(00)00177-3
44439441 161641 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 564 7 2 6 4.9 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCN(CCO)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL400631 161641 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 564 7 2 6 4.9 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCN(CCO)CC1 10.1016/j.bmcl.2006.11.034
1562 7686 13 None - 2 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for human Neuropeptide Y receptor type 1Compound was tested for human Neuropeptide Y receptor type 1
ChEMBL 475 7 3 6 4.6 Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2 10.1016/s0960-894x(00)00177-3
5312114 7686 13 None - 2 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for human Neuropeptide Y receptor type 1Compound was tested for human Neuropeptide Y receptor type 1
ChEMBL 475 7 3 6 4.6 Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2 10.1016/s0960-894x(00)00177-3
CHEMBL17645 7686 13 None - 2 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for human Neuropeptide Y receptor type 1Compound was tested for human Neuropeptide Y receptor type 1
ChEMBL 475 7 3 6 4.6 Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2 10.1016/s0960-894x(00)00177-3
CHEMBL195380 7686 13 None - 2 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for human Neuropeptide Y receptor type 1Compound was tested for human Neuropeptide Y receptor type 1
ChEMBL 475 7 3 6 4.6 Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2 10.1016/s0960-894x(00)00177-3
44377468 63274 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 525 8 2 4 5.0 O=S(=O)(NCCN1CCC(CNC2CCCc3ccc(Cl)cc3C2)CC1)c1cccc2ccccc12 10.1016/s0960-894x(02)00002-1
CHEMBL163470 63274 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 525 8 2 4 5.0 O=S(=O)(NCCN1CCC(CNC2CCCc3ccc(Cl)cc3C2)CC1)c1cccc2ccccc12 10.1016/s0960-894x(02)00002-1
44439446 97333 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 560 6 1 5 6.1 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F)N1CCN(C2CC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL238733 97333 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 560 6 1 5 6.1 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@H]1F)N1CCN(C2CC2)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL429698 220321 0 None - 0 Human 7.1 pIC50 = 7.1 Binding
Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell lineAffinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1021/jm000052z
12822578 67128 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
ChEMBL 481 5 1 8 3.5 COc1cc2nc(N3CCC(N4C(=O)CC(C5CCCCC5)CC4=O)CC3)nc(N)c2cc1OC 10.1016/s0960-894x(00)00177-3
CHEMBL17456 67128 0 None - 0 Human 5.1 pIC50 = 5.1 Binding
Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1Compound was tested for its affinity to bind with Neuropeptide Y receptor type 1
ChEMBL 481 5 1 8 3.5 COc1cc2nc(N3CCC(N4C(=O)CC(C5CCCCC5)CC4=O)CC3)nc(N)c2cc1OC 10.1016/s0960-894x(00)00177-3
73353532 97803 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 377 5 0 4 4.2 CCOc1cccc(C2(N3CCN(c4cccnc4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2397295 97803 0 None - 0 Human 6.1 pIC50 = 6.1 Binding
Displacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysisDisplacement of [125I]PYY from NPY1 receptor in human SK-N-MC cells after 1 hr by microbeta scintillation counting analysis
ChEMBL 377 5 0 4 4.2 CCOc1cccc(C2(N3CCN(c4cccnc4)CC3)C3CC(C)CC32)c1 10.1016/j.bmcl.2013.04.095
CHEMBL2314836 216288 0 None - 0 Human 8.0 pIC50 = 8.0 Binding
Displacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBNDisplacement of [125I]-NPY from Y1 receptor in human MCF7 cells in presence of 1 uM BBN
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)CC1)C(=O)O 10.1016/j.bmcl.2012.11.110
44409340 82736 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 534 6 1 6 5.4 CNC1CCC(Cn2c3c(c4ccccc42)C(=O)C(N2CCN(C)CC2)C[C@H]3Oc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL205261 82736 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 534 6 1 6 5.4 CNC1CCC(Cn2c3c(c4ccccc42)C(=O)C(N2CCN(C)CC2)C[C@H]3Oc2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL265766 103674 0 None - 0 Human 6.0 pIC50 = 6.0 Binding
Inhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cellsInhibition of I-PYY binding to Nueopeptide Y1 receptor expressed in human neuroblastoma SK-N-MC cells
ChEMBL 607 10 3 9 5.7 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)N1c1cccc(N/C(S)=N/CCCN2CCC(c3cccc(OC)c3)CC2)c1 10.1016/s0960-894x(01)00765-x
44439435 97290 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 548 5 0 5 5.9 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCN(C)C[C@H]2F)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL238728 97290 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 548 5 0 5 5.9 CN1CCN(C(=O)c2cc(Oc3ccc(Cl)cc3)c3c(c2)c2ccccc2n3C[C@@H]2CCN(C)C[C@H]2F)CC1 10.1016/j.bmcl.2006.11.034
10007341 126843 3 None - 0 Human 5.0 pIC50 = 5.0 Binding
Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1
ChEMBL 535 10 2 5 4.6 COc1ccc2c(c1)CC(CNCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00018-5
CHEMBL350620 126843 3 None - 0 Human 5.0 pIC50 = 5.0 Binding
Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1Compound was evaluated for the inhibitory activity against human Neuropeptide Y receptor type 1
ChEMBL 535 10 2 5 4.6 COc1ccc2c(c1)CC(CNCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00018-5
10007341 126843 3 None - 0 Human 5.0 pIC50 = 5.0 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 535 10 2 5 4.6 COc1ccc2c(c1)CC(CNCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
CHEMBL350620 126843 3 None - 0 Human 5.0 pIC50 = 5.0 Binding
Concentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptorConcentration that inhibited 50% of total specific binding of [125I]PYY ligand to human NPY-Y1 receptor
ChEMBL 535 10 2 5 4.6 COc1ccc2c(c1)CC(CNCC1CCN(CCNS(=O)(=O)c3cccc4ccccc34)CC1)CCC2 10.1016/s0960-894x(02)00002-1
44409155 82187 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 505 5 1 5 6.1 CC1CCN([C@@H]2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL204050 82187 0 None - 0 Human 7.0 pIC50 = 7.0 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 505 5 1 5 6.1 CC1CCN([C@@H]2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3CC3CCNCC3)C2=O)CC1 10.1016/j.bmcl.2005.11.104
44439442 97853 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 602 6 1 5 6.5 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCN(CC(F)(F)F)CC1 10.1016/j.bmcl.2006.11.034
CHEMBL239774 97853 0 None - 0 Human 5.0 pIC50 = 5.0 Binding
Displacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cellsDisplacement of [125]peptide YY from human recombinant Y1 receptor expressed in CHO cells
ChEMBL 602 6 1 5 6.5 O=C(c1cc(Oc2ccc(Cl)cc2)c2c(c1)c1ccccc1n2C[C@@H]1CCNC[C@@H]1F)N1CCN(CC(F)(F)F)CC1 10.1016/j.bmcl.2006.11.034
127041619 143911 0 None 12302 2 Human 10.6 pKd = 10.6 Binding
Binding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constantBinding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constant
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.6 pKd = 10.6 Binding
Binding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constantBinding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constant
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.6 pKd = 10.6 Binding
Binding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constantBinding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constant
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.6 pKd = 10.6 Binding
Binding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constantBinding affinity to NPY1R in human SK-N-MC cells assessed as kinetically derived dissociation rate constant
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 10.4 pKd = 10.4 Binding
Binding affinity to NPY1R in human SK-N-MC cellsBinding affinity to NPY1R in human SK-N-MC cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.4 pKd = 10.4 Binding
Binding affinity to NPY1R in human SK-N-MC cellsBinding affinity to NPY1R in human SK-N-MC cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.4 pKd = 10.4 Binding
Binding affinity to NPY1R in human SK-N-MC cellsBinding affinity to NPY1R in human SK-N-MC cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.4 pKd = 10.4 Binding
Binding affinity to NPY1R in human SK-N-MC cellsBinding affinity to NPY1R in human SK-N-MC cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 10.4 pKd = 10.4 Binding
Binding affinity to NPY1R in human SK-N-MC cells after 90 minsBinding affinity to NPY1R in human SK-N-MC cells after 90 mins
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.4 pKd = 10.4 Binding
Binding affinity to NPY1R in human SK-N-MC cells after 90 minsBinding affinity to NPY1R in human SK-N-MC cells after 90 mins
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.4 pKd = 10.4 Binding
Binding affinity to NPY1R in human SK-N-MC cells after 90 minsBinding affinity to NPY1R in human SK-N-MC cells after 90 mins
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.4 pKd = 10.4 Binding
Binding affinity to NPY1R in human SK-N-MC cells after 90 minsBinding affinity to NPY1R in human SK-N-MC cells after 90 mins
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 10.3 pKd = 10.3 Binding
Binding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysisBinding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.3 pKd = 10.3 Binding
Binding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysisBinding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.3 pKd = 10.3 Binding
Binding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysisBinding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.3 pKd = 10.3 Binding
Binding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysisBinding affinity to NPY1R in human SK-N-MC cells by Scatchard plot analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 10.1 pKd = 10.1 Binding
Binding affinity to NPY1R in human MCF7 cellsBinding affinity to NPY1R in human MCF7 cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.1 pKd = 10.1 Binding
Binding affinity to NPY1R in human MCF7 cellsBinding affinity to NPY1R in human MCF7 cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.1 pKd = 10.1 Binding
Binding affinity to NPY1R in human MCF7 cellsBinding affinity to NPY1R in human MCF7 cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.1 pKd = 10.1 Binding
Binding affinity to NPY1R in human MCF7 cellsBinding affinity to NPY1R in human MCF7 cells
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 10.1 pKd = 10.1 Binding
Binding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysisBinding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.1 pKd = 10.1 Binding
Binding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysisBinding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.1 pKd = 10.1 Binding
Binding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysisBinding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.1 pKd = 10.1 Binding
Binding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysisBinding affinity to NPY1R in human MCF7-Y1 cells by Scatchard plot analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 9.9 pKd = 9.9 Binding
Binding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysisBinding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.9 pKd = 9.9 Binding
Binding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysisBinding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.9 pKd = 9.9 Binding
Binding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysisBinding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.9 pKd = 9.9 Binding
Binding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysisBinding affinity to NPY1R in human MCF7 cells after 90 mins by microbeta2 plate counting analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
25181112 185734 0 None - 1 Human 9.0 pKd = 9.0 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cells by kinetic experimentBinding affinity to neuropeptide Y1 receptor in human MCF7 cells by kinetic experiment
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL446342 185734 0 None - 1 Human 9.0 pKd = 9.0 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cells by kinetic experimentBinding affinity to neuropeptide Y1 receptor in human MCF7 cells by kinetic experiment
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470495 185734 0 None - 1 Human 9.0 pKd = 9.0 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cells by kinetic experimentBinding affinity to neuropeptide Y1 receptor in human MCF7 cells by kinetic experiment
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
25181112 185734 0 None - 1 Human 9.0 pKd = 9.0 Binding
Binding affinity to neuropeptide Y1 receptor in human SK-N-MC cells by kinetic experimentBinding affinity to neuropeptide Y1 receptor in human SK-N-MC cells by kinetic experiment
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL446342 185734 0 None - 1 Human 9.0 pKd = 9.0 Binding
Binding affinity to neuropeptide Y1 receptor in human SK-N-MC cells by kinetic experimentBinding affinity to neuropeptide Y1 receptor in human SK-N-MC cells by kinetic experiment
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470495 185734 0 None - 1 Human 9.0 pKd = 9.0 Binding
Binding affinity to neuropeptide Y1 receptor in human SK-N-MC cells by kinetic experimentBinding affinity to neuropeptide Y1 receptor in human SK-N-MC cells by kinetic experiment
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
25181112 185734 0 None - 1 Human 8.9 pKd = 8.9 Binding
Binding affinity to neuropeptide Y1 receptor in human SK-N-MC cellsBinding affinity to neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL446342 185734 0 None - 1 Human 8.9 pKd = 8.9 Binding
Binding affinity to neuropeptide Y1 receptor in human SK-N-MC cellsBinding affinity to neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470495 185734 0 None - 1 Human 8.9 pKd = 8.9 Binding
Binding affinity to neuropeptide Y1 receptor in human SK-N-MC cellsBinding affinity to neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
25181112 185734 0 None - 1 Human 8.9 pKd = 8.9 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL446342 185734 0 None - 1 Human 8.9 pKd = 8.9 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470495 185734 0 None - 1 Human 8.9 pKd = 8.9 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
44346892 168707 0 None - 1 Human 7.0 pKd = 7 Binding
Displacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cellsDisplacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cells
ChEMBL 3395 75 48 47 -15.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@]1(C)NC(=O)CC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm00098a009
91928654 168707 0 None - 1 Human 7.0 pKd = 7 Binding
Displacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cellsDisplacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cells
ChEMBL 3395 75 48 47 -15.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@]1(C)NC(=O)CC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm00098a009
CHEMBL415353 168707 0 None - 1 Human 7.0 pKd = 7 Binding
Displacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cellsDisplacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cells
ChEMBL 3395 75 48 47 -15.1 CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@]1(C)NC(=O)CC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)N[C@@H](C)C(=O)N[C@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm00098a009
CHEMBL3559527 218520 0 None -112 2 Human 7.0 pKd = 7 Binding
Displacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cellsDisplacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00098a009
127042586 143779 1 None - 1 Human 8.7 pKd = 8.7 Binding
Binding affinity to NPY1R in human SK-N-MC cells by liquid scintillation counting assayBinding affinity to NPY1R in human SK-N-MC cells by liquid scintillation counting assay
ChEMBL 643 17 7 5 3.0 CCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746028 143779 1 None - 1 Human 8.7 pKd = 8.7 Binding
Binding affinity to NPY1R in human SK-N-MC cells by liquid scintillation counting assayBinding affinity to NPY1R in human SK-N-MC cells by liquid scintillation counting assay
ChEMBL 643 17 7 5 3.0 CCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
1485 7418 31 None 1 4 Human 8.7 pKd = 8.7 Binding
Binding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assayBinding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
3474 7418 31 None 1 4 Human 8.7 pKd = 8.7 Binding
Binding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assayBinding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
5311023 7418 31 None 1 4 Human 8.7 pKd = 8.7 Binding
Binding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assayBinding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL332347 7418 31 None 1 4 Human 8.7 pKd = 8.7 Binding
Binding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assayBinding affinity to NPY1R in human SK-N-MC cells after 2 hrs by liquid scintillation counting assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
25181112 185734 0 None - 1 Human 8.5 pKd = 8.5 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cellsBinding affinity to neuropeptide Y1 receptor in human MCF7 cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL446342 185734 0 None - 1 Human 8.5 pKd = 8.5 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cellsBinding affinity to neuropeptide Y1 receptor in human MCF7 cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470495 185734 0 None - 1 Human 8.5 pKd = 8.5 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cellsBinding affinity to neuropeptide Y1 receptor in human MCF7 cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
52953220 69927 0 None - 1 Human 8.3 pKd = 8.3 Binding
Binding affinity at Y1R in human MCF-7 cells by flow cytometryBinding affinity at Y1R in human MCF-7 cells by flow cytometry
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774344 69927 0 None - 1 Human 8.3 pKd = 8.3 Binding
Binding affinity at Y1R in human MCF-7 cells by flow cytometryBinding affinity at Y1R in human MCF-7 cells by flow cytometry
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789732 69927 0 None - 1 Human 8.3 pKd = 8.3 Binding
Binding affinity at Y1R in human MCF-7 cells by flow cytometryBinding affinity at Y1R in human MCF-7 cells by flow cytometry
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL409167 219527 2 None -426 2 Human 6.1 pKd = 6.1 Binding
Displacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cellsDisplacement of l25I-PYY from Neuropeptide Y receptor type 1 of human neuroblastoma SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00098a009
162647593 190417 0 None - 1 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 619 15 7 5 1.8 N/C(=N/C(=O)NCCNC(=O)CF)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4746035 190417 0 None - 1 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 619 15 7 5 1.8 N/C(=N/C(=O)NCCNC(=O)CF)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802520 190417 0 None - 1 Human 10.5 pKi = 10.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 619 15 7 5 1.8 N/C(=N/C(=O)NCCNC(=O)CF)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
10008757 195792 0 None 7585 2 Human 10.4 pKi = 10.4 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 10.4 pKi = 10.4 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
9987422 126693 0 None - 1 Human 10.3 pKi = 10.3 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 720 15 0 6 8.2 Ic1ccc(CCN2CCC(CCCn3c(COc4ccccc4)nc4c(OCCCN5CCCCC5)cccc43)CC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL349328 126693 0 None - 1 Human 10.3 pKi = 10.3 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 720 15 0 6 8.2 Ic1ccc(CCN2CCC(CCCn3c(COc4ccccc4)nc4c(OCCCN5CCCCC5)cccc43)CC2)cc1 10.1016/s0960-894x(99)00082-7
162673313 190550 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 635 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)CCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4794692 190550 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 635 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)CCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803933 190550 0 None - 1 Human 10.3 pKi = 10.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 635 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)CCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162646865 190413 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 601 14 7 5 1.9 CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4743976 190413 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 601 14 7 5 1.9 CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802480 190413 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 601 14 7 5 1.9 CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
10008757 195792 0 None 7585 2 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10030299 195994 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)Displacement of [3H]propionyl-pNPY from NPY1R (unknown origin)
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
162659769 190479 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CC(=O)NCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4762668 190479 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CC(=O)NCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803176 190479 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CC(=O)NCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162645700 190408 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 637 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)C(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4743858 190408 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 637 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)C(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802419 190408 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 637 15 7 5 2.1 N/C(=N/C(=O)NCCNC(=O)C(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL2110365 215992 4 None 17 4 Human 10.2 pKi = 10.2 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm010031k
162652126 190434 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 655 14 7 5 2.4 N/C(=N/C(=O)NCCNC(=O)C(F)(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4751322 190434 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 655 14 7 5 2.4 N/C(=N/C(=O)NCCNC(=O)C(F)(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802763 190434 0 None - 1 Human 10.2 pKi = 10.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 655 14 7 5 2.4 N/C(=N/C(=O)NCCNC(=O)C(F)(F)F)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162652761 190440 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 629 16 7 5 2.6 CCC(=O)NCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4752392 190440 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 629 16 7 5 2.6 CCC(=O)NCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802798 190440 0 None - 1 Human 10.1 pKi = 10.1 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 629 16 7 5 2.6 CCC(=O)NCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
127041619 143911 0 None 12302 2 Human 10.1 pKi = 10.1 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.1 pKi = 10.1 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.1 pKi = 10.1 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.1 pKi = 10.1 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
1504 9583 8 None -1 10 Human 10.0 pKi = 10.0 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
1518 9583 8 None -1 10 Human 10.0 pKi = 10.0 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
1521 9583 8 None -1 10 Human 10.0 pKi = 10.0 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
24868177 9583 8 None -1 10 Human 10.0 pKi = 10.0 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
44288922 9583 8 None -1 10 Human 10.0 pKi = 10.0 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
77068007 9583 8 None -1 10 Human 10.0 pKi = 10.0 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
90479759 9583 8 None -1 10 Human 10.0 pKi = 10.0 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
CHEMBL438945 9583 8 None -1 10 Human 10.0 pKi = 10.0 Binding
Binding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assayBinding affinity to human neuropeptide Y receptor type 1 by radioligand displacement assay
ChEMBL None None None None 10.1016/j.ejmech.2013.01.044
10008757 195792 0 None 7585 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL508974 195792 0 None 7585 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
10030299 195994 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL511460 195994 0 None - 1 Human 10.0 pKi = 10 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
127041619 143911 0 None 12302 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 10.0 pKi = 10 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysis
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44372750 55476 0 None - 1 Human 10.0 pKi = 10.0 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 615 16 0 7 7.2 c1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCN(CCCN3CCCCC3)CC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL155802 55476 0 None - 1 Human 10.0 pKi = 10.0 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 615 16 0 7 7.2 c1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCN(CCCN3CCCCC3)CC2)cc1 10.1016/s0960-894x(99)00082-7
44372384 126527 0 None - 1 Human 10.0 pKi = 10.0 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 622 16 0 7 7.6 O=C(CCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1)c1ccccc1 10.1016/s0960-894x(99)00082-7
CHEMBL347807 126527 0 None - 1 Human 10.0 pKi = 10.0 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 622 16 0 7 7.6 O=C(CCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1)c1ccccc1 10.1016/s0960-894x(99)00082-7
162653845 190446 0 None - 1 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 613 15 7 5 2.0 C=CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4753520 190446 0 None - 1 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 613 15 7 5 2.0 C=CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802860 190446 0 None - 1 Human 10.0 pKi = 10.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 613 15 7 5 2.0 C=CC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
10008757 195792 0 None 7585 2 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
91928728 217504 17 None -7 2 Human 9.9 pKi = 9.9 Binding
Displacement of radiolabeled NPY from human neuropeptide Y1 receptorDisplacement of radiolabeled NPY from human neuropeptide Y1 receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm8007618
CHEMBL267633 217504 17 None -7 2 Human 9.9 pKi = 9.9 Binding
Displacement of radiolabeled NPY from human neuropeptide Y1 receptorDisplacement of radiolabeled NPY from human neuropeptide Y1 receptor
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm8007618
56841989 220199 6 None 1 7 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4281479 220199 6 None 1 7 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
162667448 190516 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 679 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)CBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4786911 190516 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 679 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)CBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803593 190516 0 None - 1 Human 9.9 pKi = 9.9 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 679 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)CBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
56841989 220199 6 None 1 7 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4281479 220199 6 None 1 7 Human 9.9 pKi = 9.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
44372383 175836 0 None - 1 Human 9.9 pKi = 9.9 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 636 17 0 7 8.0 O=C(CCCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1)c1ccccc1 10.1016/s0960-894x(99)00082-7
CHEMBL439643 175836 0 None - 1 Human 9.9 pKi = 9.9 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 636 17 0 7 8.0 O=C(CCCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1)c1ccccc1 10.1016/s0960-894x(99)00082-7
162675643 190563 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 617 15 8 6 0.8 N/C(=N/C(=O)NCCNC(=O)CO)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4798118 190563 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 617 15 8 6 0.8 N/C(=N/C(=O)NCCNC(=O)CO)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4804067 190563 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 617 15 8 6 0.8 N/C(=N/C(=O)NCCNC(=O)CO)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
10030299 195994 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 9.8 pKi = 9.8 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44372422 126370 0 None - 1 Human 9.7 pKi = 9.7 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 606 15 0 6 8.1 C(=C\c1ccccc1)\CN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL346243 126370 0 None - 1 Human 9.7 pKi = 9.7 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 606 15 0 6 8.1 C(=C\c1ccccc1)\CN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
44372692 126291 0 None - 1 Human 9.7 pKi = 9.7 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 594 15 0 6 7.6 c1ccc(CCN2CCC(CCCn3c(COc4ccccc4)nc4c(OCCCN5CCCCC5)cccc43)CC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL345581 126291 0 None - 1 Human 9.7 pKi = 9.7 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 594 15 0 6 7.6 c1ccc(CCN2CCC(CCCn3c(COc4ccccc4)nc4c(OCCCN5CCCCC5)cccc43)CC2)cc1 10.1016/s0960-894x(99)00082-7
1504 9583 8 None -1 10 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
1518 9583 8 None -1 10 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
1521 9583 8 None -1 10 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
24868177 9583 8 None -1 10 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
44288922 9583 8 None -1 10 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
77068007 9583 8 None -1 10 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
90479759 9583 8 None -1 10 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
CHEMBL438945 9583 8 None -1 10 Human 9.7 pKi = 9.7 Binding
Displacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 minsDisplacement of [125I]Peptide YY from neuropeptide Y receptor type 1 in human SK-N-MC cells after 60 mins
ChEMBL None None None None 10.1016/j.bmcl.2013.01.025
10008757 195792 0 None 7585 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.7 pKi = 9.7 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041619 143911 0 None 12302 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assayDisplacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assayDisplacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assayDisplacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assayDisplacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
162653308 190444 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 616 15 8 6 0.8 NCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4752935 190444 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 616 15 8 6 0.8 NCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802829 190444 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 616 15 8 6 0.8 NCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
10030299 195994 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in human HEL cells preincubated for 30 mins followed by radioligand addition at 60 to 90 mins by flow cytometric analysis
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL4284905 220229 0 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
1528 7417 22 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 10.1016/j.bmc.2011.03.045
5311022 7417 22 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 10.1016/j.bmc.2011.03.045
CHEMBL1774204 7417 22 None - 1 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 529 13 6 4 1.8 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)CNC(=O)N 10.1016/j.bmc.2011.03.045
CHEMBL4284905 220229 0 None 1 4 Human 9.6 pKi = 9.6 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
155523949 177637 0 None 676 2 Human 9.6 pKi = 9.6 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2259 56 35 29 -7.7 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4454036 177637 0 None 676 2 Human 9.6 pKi = 9.6 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2259 56 35 29 -7.7 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL411117 219644 0 None 123 4 Human 9.6 pKi = 9.6 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)OC)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)OC)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm010031k
155537755 179141 0 None 467 2 Human 9.6 pKi = 9.6 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2309 56 36 30 -7.8 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4476074 179141 0 None 467 2 Human 9.6 pKi = 9.6 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2309 56 36 30 -7.8 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
10008757 195792 0 None 7585 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assayDisplacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assay
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.6 pKi = 9.6 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assayDisplacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assay
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44372776 55780 0 None - 1 Human 9.5 pKi = 9.5 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 600 15 0 6 8.3 c1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCN(CCC3CCCCC3)CC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL156076 55780 0 None - 1 Human 9.5 pKi = 9.5 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 600 15 0 6 8.3 c1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCN(CCC3CCCCC3)CC2)cc1 10.1016/s0960-894x(99)00082-7
44373119 126563 0 None - 1 Human 9.5 pKi = 9.5 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 560 15 0 6 7.4 CC(C)CCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL348123 126563 0 None - 1 Human 9.5 pKi = 9.5 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 560 15 0 6 7.4 CC(C)CCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
10030299 195994 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assayDisplacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assay
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assayDisplacement of [3H]propionyl-pNPY from NPY1R in human SK-N-MC cells compound treated immediately post radioligand treatment measured after 2 hrs by radioligand binding assay
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
127041306 143838 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
10008757 195792 0 None 7585 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
162655600 190455 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 629 15 7 5 2.5 CC(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4755692 190455 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 629 15 7 5 2.5 CC(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802951 190455 0 None - 1 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 629 15 7 5 2.5 CC(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
127041619 143911 0 None 12302 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746386 143911 0 None 12302 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747715 143911 0 None 12302 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747822 143911 0 None 12302 2 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 615 15 7 5 2.2 CCC(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44372508 126872 0 None - 1 Human 9.5 pKi = 9.5 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 610 15 1 7 7.3 Oc1ccc(CCN2CCC(CCCn3c(COc4ccccc4)nc4c(OCCCN5CCCCC5)cccc43)CC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL350917 126872 0 None - 1 Human 9.5 pKi = 9.5 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 610 15 1 7 7.3 Oc1ccc(CCN2CCC(CCCn3c(COc4ccccc4)nc4c(OCCCN5CCCCC5)cccc43)CC2)cc1 10.1016/s0960-894x(99)00082-7
127041327 143909 0 None 1445 3 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3746851 143909 0 None 1445 3 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3747820 143909 0 None 1445 3 Human 9.5 pKi = 9.5 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
44372691 126369 0 None - 1 Human 9.4 pKi = 9.4 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 608 16 0 6 8.0 c1ccc(CCCN2CCC(CCCn3c(COc4ccccc4)nc4c(OCCCN5CCCCC5)cccc43)CC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL346242 126369 0 None - 1 Human 9.4 pKi = 9.4 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 608 16 0 6 8.0 c1ccc(CCCN2CCC(CCCn3c(COc4ccccc4)nc4c(OCCCN5CCCCC5)cccc43)CC2)cc1 10.1016/s0960-894x(99)00082-7
155517812 176989 0 None 467 2 Human 9.4 pKi = 9.4 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2266 54 33 29 -6.0 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4445317 176989 0 None 467 2 Human 9.4 pKi = 9.4 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2266 54 33 29 -6.0 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
162672910 190549 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 649 16 7 5 2.5 N/C(=N/C(=O)NCCNC(=O)CCCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4795468 190549 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 649 16 7 5 2.5 N/C(=N/C(=O)NCCNC(=O)CCCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803913 190549 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 649 16 7 5 2.5 N/C(=N/C(=O)NCCNC(=O)CCCl)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44372858 126562 0 None - 1 Human 9.4 pKi = 9.4 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 586 14 0 6 7.9 c1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCN(CC3CCCCC3)CC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL348119 126562 0 None - 1 Human 9.4 pKi = 9.4 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 586 14 0 6 7.9 c1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCN(CC3CCCCC3)CC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL4279973 220180 0 None -2 4 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4279973 220180 0 None -2 4 Human 9.4 pKi = 9.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
10030299 195994 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL511460 195994 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 544 12 6 4 2.7 CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL4299523 220354 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@H](C)CC 10.1021/acs.jmedchem.5b00925
CHEMBL4299523 220354 0 None - 1 Human 9.4 pKi = 9.4 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells preincubated with radioligand followed by protein addition for 60 mins by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells preincubated with radioligand followed by protein addition for 60 mins by radioligand binding assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@H](C)CC 10.1021/acs.jmedchem.5b00925
10008757 195792 0 None 7585 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL508974 195792 0 None 7585 2 Human 9.4 pKi = 9.4 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 602 14 6 6 2.3 CCOC(=O)CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44283050 166261 0 None 144 4 Human 9.3 pKi = 9.3 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL 2323 60 32 30 -6.7 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm010031k
91931647 166261 0 None 144 4 Human 9.3 pKi = 9.3 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL 2323 60 32 30 -6.7 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm010031k
CHEMBL410166 166261 0 None 144 4 Human 9.3 pKi = 9.3 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL 2323 60 32 30 -6.7 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/jm010031k
127041306 143838 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746870 143838 0 None - 1 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 616 15 6 6 2.7 CCOC(=O)CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
1504 9583 8 None -1 10 Human 9.3 pKi = 9.3 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None None 10.1021/jm4008505
1518 9583 8 None -1 10 Human 9.3 pKi = 9.3 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None None 10.1021/jm4008505
1521 9583 8 None -1 10 Human 9.3 pKi = 9.3 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None None 10.1021/jm4008505
24868177 9583 8 None -1 10 Human 9.3 pKi = 9.3 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None None 10.1021/jm4008505
44288922 9583 8 None -1 10 Human 9.3 pKi = 9.3 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None None 10.1021/jm4008505
77068007 9583 8 None -1 10 Human 9.3 pKi = 9.3 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None None 10.1021/jm4008505
90479759 9583 8 None -1 10 Human 9.3 pKi = 9.3 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None None 10.1021/jm4008505
CHEMBL438945 9583 8 None -1 10 Human 9.3 pKi = 9.3 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None None 10.1021/jm4008505
91928728 217504 17 None -7 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm801018u
CHEMBL267633 217504 17 None -7 2 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm801018u
CHEMBL429531 220316 15 None -6 4 Human 9.3 pKi = 9.3 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm010031k
127041327 143909 0 None 1445 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3746851 143909 0 None 1445 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
CHEMBL3747820 143909 0 None 1445 3 Human 9.3 pKi = 9.3 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 611 13 6 7 2.0 Cn1cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)nn1 10.1021/acs.jmedchem.5b00925
155541756 179818 0 None 426 2 Human 9.2 pKi = 9.2 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2266 54 33 29 -6.0 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4519035 179818 0 None 426 2 Human 9.2 pKi = 9.2 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2266 54 33 29 -6.0 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4299523 220354 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@H](C)CC 10.1021/acs.jmedchem.5b00925
162669845 190527 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 693 16 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)CCBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4789673 190527 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 693 16 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)CCBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803729 190527 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 693 16 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)CCBr)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4299523 220354 0 None - 1 Human 9.2 pKi = 9.2 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL None None None CC[C@@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@H](C)CC 10.1021/acs.jmedchem.5b00925
44373122 175141 0 None - 1 Human 9.2 pKi = 9.2 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 544 15 0 6 6.9 C=CCCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL434467 175141 0 None - 1 Human 9.2 pKi = 9.2 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 544 15 0 6 6.9 C=CCCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
10326097 57571 0 None - 1 Human 9.1 pKi = 9.1 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCCC2CCCNC2)c2ccccc12 10.1016/s0960-894x(99)00082-7
CHEMBL157661 57571 0 None - 1 Human 9.1 pKi = 9.1 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCCC2CCCNC2)c2ccccc12 10.1016/s0960-894x(99)00082-7
9916525 119148 1 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC[C@@H]2CCCNC2)c2ccccc12 10.1021/jm970512x
CHEMBL329536 119148 1 None - 1 Human 9.1 pKi = 9.1 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC[C@@H]2CCCNC2)c2ccccc12 10.1021/jm970512x
9916525 119148 1 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC[C@@H]2CCCNC2)c2ccccc12 10.1021/jm9706630
CHEMBL329536 119148 1 None - 1 Human 9.1 pKi = 9.1 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC[C@@H]2CCCNC2)c2ccccc12 10.1021/jm9706630
CHEMBL4286615 220243 0 None -79 4 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
CHEMBL4286615 220243 0 None -79 4 Human 9.1 pKi = 9.1 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
44373166 59327 0 None - 1 Human 9.1 pKi = 9.1 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 546 14 0 6 7.0 CC(C)CN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL159220 59327 0 None - 1 Human 9.1 pKi = 9.1 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 546 14 0 6 7.0 CC(C)CN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL3349022 218183 0 None -3 2 Human 9.1 pKi = 9.1 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
46934142 22920 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 643 18 6 7 4.3 COC(=O)CCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
CHEMBL1223992 22920 0 None - 1 Human 9.1 pKi = 9.1 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 643 18 6 7 4.3 COC(=O)CCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
1485 7418 31 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
3474 7418 31 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
5311023 7418 31 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL332347 7418 31 None 1 4 Human 9.0 pKi = 9 Binding
Displacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of (R)-Na-Diphenylacetyl-Nomega[2-([2,3-3H]-propionylamino)ethyl]aminocarbonyl (4-hydroxybenzyl)-argininamide from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
9869041 68418 12 None 3 2 Human 9.0 pKi = 9 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 463 7 2 7 4.5 COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771259 68418 12 None 3 2 Human 9.0 pKi = 9 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 463 7 2 7 4.5 COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
25181112 185734 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL446342 185734 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470495 185734 0 None - 1 Human 9.0 pKi = 9 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL2110365 215992 4 None 17 4 Human 9.0 pKi = 9.0 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
162659745 190478 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 641 15 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)C1CCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4762044 190478 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 641 15 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)C1CCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803174 190478 0 None - 1 Human 9.0 pKi = 9.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 641 15 7 5 2.6 N/C(=N/C(=O)NCCNC(=O)C1CCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162649085 190421 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 627 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)C1CC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4745338 190421 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 627 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)C1CC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802600 190421 0 None - 1 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 627 15 7 5 2.2 N/C(=N/C(=O)NCCNC(=O)C1CC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL3349022 218183 0 None -3 2 Human 8.9 pKi = 8.9 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
25181112 185734 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cellsBinding affinity to neuropeptide Y1 receptor in human MCF7 cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL446342 185734 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cellsBinding affinity to neuropeptide Y1 receptor in human MCF7 cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470495 185734 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity to neuropeptide Y1 receptor in human MCF7 cellsBinding affinity to neuropeptide Y1 receptor in human MCF7 cells
ChEMBL 529 12 5 4 2.9 CCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
1485 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2008.09.033
3474 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2008.09.033
5311023 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2008.09.033
CHEMBL332347 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2008.09.033
1485 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2011.03.045
3474 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2011.03.045
5311023 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2011.03.045
CHEMBL332347 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2011.03.045
1485 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2010.07.028
3474 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2010.07.028
5311023 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2010.07.028
CHEMBL332347 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2010.07.028
1485 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2013.08.065
3474 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2013.08.065
5311023 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2013.08.065
CHEMBL332347 7418 31 None 1 4 Human 8.9 pKi = 8.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2013.08.065
10531484 120246 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC[C@H]2CCCNC2)c2ccccc12 10.1021/jm970512x
CHEMBL331937 120246 0 None - 1 Human 8.9 pKi = 8.9 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 590 11 1 6 6.8 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC[C@H]2CCCNC2)c2ccccc12 10.1021/jm970512x
CHEMBL3349022 218183 0 None -3 2 Human 8.8 pKi = 8.8 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
1485 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
3474 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
5311023 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
CHEMBL332347 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
1485 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
3474 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
5311023 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL332347 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
1485 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
3474 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
5311023 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL332347 7418 31 None 1 4 Human 8.8 pKi = 8.8 Binding
Displacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysisDisplacement of [3H]propionyl-pNPY from NPY1R in HEL cells after 60 to 90 mins by flow cytometric analysis
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/acs.jmedchem.5b00925
CHEMBL3349022 218183 0 None -3 2 Human 8.8 pKi = 8.8 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
44372820 58437 0 None - 1 Human 8.8 pKi = 8.8 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 532 13 0 6 6.8 CC(C)N1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL158392 58437 0 None - 1 Human 8.8 pKi = 8.8 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 532 13 0 6 6.8 CC(C)N1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
44372775 55627 0 None - 1 Human 8.8 pKi = 8.8 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 504 12 0 6 6.0 CN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL155925 55627 0 None - 1 Human 8.8 pKi = 8.8 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 504 12 0 6 6.0 CN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
44372777 126526 0 None - 1 Human 8.8 pKi = 8.8 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 530 14 0 6 6.5 C=CCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL347804 126526 0 None - 1 Human 8.8 pKi = 8.8 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 530 14 0 6 6.5 C=CCN1CCC(CCCn2c(COc3ccccc3)nc3c(OCCCN4CCCCC4)cccc32)CC1 10.1016/s0960-894x(99)00082-7
10414488 209458 0 None - 1 Human 8.8 pKi = 8.8 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 524 12 1 6 6.3 Clc1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL61532 209458 0 None - 1 Human 8.8 pKi = 8.8 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 524 12 1 6 6.3 Clc1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1016/s0960-894x(99)00082-7
10414488 209458 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 1 6 6.3 Clc1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL61532 209458 0 None - 1 Human 8.8 pKi = 8.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 1 6 6.3 Clc1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL3349022 218183 0 None -3 2 Human 8.7 pKi = 8.7 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL3349022 218183 0 None -3 2 Human 8.7 pKi = 8.7 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
10555187 124749 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 576 10 1 6 6.4 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC2CCNCC2)c2ccccc12 10.1021/jm970512x
CHEMBL340369 124749 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 576 10 1 6 6.4 O=C(CN1CCC(N2CCCCC2)CC1)c1c(COc2ccc(Cl)cc2)n(CCC2CCNCC2)c2ccccc12 10.1021/jm970512x
45273656 202592 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 529 6 1 3 6.0 Cc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL558133 202592 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 529 6 1 3 6.0 Cc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL125807 24336 0 None - 1 Human 8.0 pKi = 8 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 560 9 3 7 5.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3ccccc3)CC2)c1 10.1016/s0960-894x(01)00761-2
44409242 148145 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 538 5 0 6 4.9 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@@H]3CCN(C)C[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
CHEMBL383763 148145 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cellsDisplacement of [125I]PYY from human recombinant NPY1 receptor expressed in CHO cells
ChEMBL 538 5 0 6 4.9 CN1CCN(C2C[C@@H](Oc3ccc(Cl)cc3)c3c(c4ccccc4n3C[C@@H]3CCN(C)C[C@@H]3F)C2=O)CC1 10.1016/j.bmcl.2005.11.104
54582376 69930 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1657 47 12 12 10.8 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
91932453 69930 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1657 47 12 12 10.8 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774346 69930 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1657 47 12 12 10.8 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789739 69930 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1657 47 12 12 10.8 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
10577912 213153 0 None - 1 Human 7.0 pKi = 7 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 521 6 4 3 5.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3cccc(F)c3F)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL87548 213153 0 None - 1 Human 7.0 pKi = 7 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 521 6 4 3 5.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3cccc(F)c3F)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL4277697 220155 0 None -25 4 Human 6.0 pKi = 6 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
73351127 109340 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 899 27 12 9 -0.8 NCCNC(=O)CCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440904 109340 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 899 27 12 9 -0.8 NCCNC(=O)CCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040737 109340 0 None - 1 Human 6.0 pKi = 6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 899 27 12 9 -0.8 NCCNC(=O)CCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL4281120 220193 0 None -39 4 Human 5.0 pKi = 5 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4283257 220216 0 None -5011 4 Human 5.0 pKi = 5 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4290488 220275 0 None -19 4 Human 5.0 pKi = 5 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(CCCNC(=N)N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
162661557 190487 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 821 18 6 5 6.1 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4763629 190487 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 821 18 6 5 6.1 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803258 190487 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 821 18 6 5 6.1 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL338296 123662 0 None - 1 Human 7.0 pKi = 7.0 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 605 11 3 9 4.8 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00761-2
46879455 12258 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 368 5 2 6 4.8 Cc1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1076207 12258 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 368 5 2 6 4.8 Cc1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
46879823 13051 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 478 6 2 6 7.3 Clc1cccc(C2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)c1 10.1016/j.bmcl.2009.09.048
CHEMBL1081713 13051 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 478 6 2 6 7.3 Clc1cccc(C2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)c1 10.1016/j.bmcl.2009.09.048
CHEMBL124335 23520 0 None - 1 Human 7.0 pKi = 7.0 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 591 10 4 9 4.5 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3O)CC2)c1 10.1016/s0960-894x(01)00761-2
21188508 126213 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 487 9 0 4 7.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(Cc2ccccc2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL344952 126213 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 487 9 0 4 7.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(Cc2ccccc2)CC1 10.1016/s0960-894x(98)00048-1
44362830 128059 0 None - 1 Human 8.0 pKi = 8.0 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 516 9 0 5 6.0 COCc1cc(Br)ccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL357914 128059 0 None - 1 Human 8.0 pKi = 8.0 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 516 9 0 5 6.0 COCc1cc(Br)ccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
44362352 126163 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 467 10 0 4 7.1 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCC(C)C)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL344530 126163 0 None - 1 Human 8.0 pKi = 8.0 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 467 10 0 4 7.1 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCC(C)C)CC1 10.1016/s0960-894x(98)00048-1
49865805 22921 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 861 21 6 15 2.0 CC(=O)OC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
CHEMBL1223993 22921 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 861 21 6 15 2.0 CC(=O)OC[C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](OC(C)=O)C(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
CHEMBL2440916 217741 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None CCC(=O)NCCN(CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040674 217741 0 None 4 2 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None CCC(=O)NCCN(CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
45270992 203224 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 5.7 COc1ccc([C@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL563052 203224 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 5.7 COc1ccc([C@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
44362822 41168 0 None - 1 Human 5.0 pKi = 5.0 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 371 5 0 3 6.1 Clc1ccc(OCc2sc3ccccc3c2CN2CCCCC2)cc1 10.1016/s0960-894x(99)00019-0
CHEMBL142796 41168 0 None - 1 Human 5.0 pKi = 5.0 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 371 5 0 3 6.1 Clc1ccc(OCc2sc3ccccc3c2CN2CCCCC2)cc1 10.1016/s0960-894x(99)00019-0
46879457 12679 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 372 5 2 6 4.6 Fc1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1079610 12679 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 372 5 2 6 4.6 Fc1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
15383697 108551 0 None - 1 Human 6.0 pKi = 6.0 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 359 4 1 7 2.6 COc1ccc(S(=O)(=O)c2cc(N)c3ncccc3c2[N+](=O)[O-])cc1 10.1016/0960-894X(96)00319-8
CHEMBL299965 108551 0 None - 1 Human 6.0 pKi = 6.0 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 359 4 1 7 2.6 COc1ccc(S(=O)(=O)c2cc(N)c3ncccc3c2[N+](=O)[O-])cc1 10.1016/0960-894X(96)00319-8
CHEMBL196546 78487 0 None - 1 Human 5.9 pKi = 5.9 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 633 10 3 9 5.6 CO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC(C)(C)C)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00761-2
CHEMBL269267 217563 0 None -13 2 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]PYY from NPY1 receptor expressed in human SK-N-MC cellsDisplacement of [125I]PYY from NPY1 receptor expressed in human SK-N-MC cells
ChEMBL None None None CC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1016/j.bmcl.2006.10.007
19426761 201524 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 343 3 1 6 2.9 Cc1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+](=O)[O-] 10.1016/0960-894X(96)00319-8
CHEMBL53657 201524 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 343 3 1 6 2.9 Cc1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+](=O)[O-] 10.1016/0960-894X(96)00319-8
44563341 186037 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 515 11 5 4 2.6 CC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL472901 186037 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 515 11 5 4 2.6 CC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL124152 23396 0 None - 1 Human 7.9 pKi = 7.9 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 591 10 3 9 4.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00761-2
CHEMBL4287140 220247 0 None -8 4 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
155565033 182321 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2407 58 36 30 -5.2 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4578617 182321 0 None 4 2 Human 7.9 pKi = 7.9 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2407 58 36 30 -5.2 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
44362411 40914 0 None - 1 Human 6.9 pKi = 6.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 550 7 0 4 6.6 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL142584 40914 0 None - 1 Human 6.9 pKi = 6.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 550 7 0 4 6.6 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
44362410 172036 0 None - 1 Human 6.9 pKi = 6.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 422 7 0 4 5.7 Cc1ccc(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)c(C)c1 10.1016/s0960-894x(99)00019-0
CHEMBL423012 172036 0 None - 1 Human 6.9 pKi = 6.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 422 7 0 4 5.7 Cc1ccc(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)c(C)c1 10.1016/s0960-894x(99)00019-0
CHEMBL2371910 216929 0 None -31 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
45270142 202103 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 530 7 1 6 5.8 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4nnc(C)o4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL551608 202103 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 530 7 1 6 5.8 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4nnc(C)o4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
73357158 109326 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 971 30 13 10 -1.3 NCCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440906 109326 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 971 30 13 10 -1.3 NCCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040672 109326 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 971 30 13 10 -1.3 NCCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
10720203 213169 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 500 5 3 4 5.7 CC(C)(C)OC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL87667 213169 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 500 5 3 4 5.7 CC(C)(C)OC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
44362998 127851 0 None - 1 Human 4.9 pKi = 4.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 490 7 0 4 7.1 CN(C)C1CCN(CCc2c(C(C)(C)Oc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL357010 127851 0 None - 1 Human 4.9 pKi = 4.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 490 7 0 4 7.1 CN(C)C1CCN(CCc2c(C(C)(C)Oc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
10815605 213585 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 397 8 1 4 5.4 Clc1ccc(OCc2nc3ccccc3n2CCCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL90369 213585 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 397 8 1 4 5.4 Clc1ccc(OCc2nc3ccccc3n2CCCCC2CCCNC2)cc1 10.1021/jm9706630
46879822 13050 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 478 6 2 6 7.3 Clc1ccc(C2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL1081712 13050 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 478 6 2 6 7.3 Clc1ccc(C2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
46879521 12839 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 388 5 2 6 5.1 Clc1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1080617 12839 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 388 5 2 6 5.1 Clc1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
44362921 171689 0 None - 1 Human 4.9 pKi = 4.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 458 6 0 3 6.9 CN(C)C1CCN(CCc2c(/C=C/c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL422294 171689 0 None - 1 Human 4.9 pKi = 4.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 458 6 0 3 6.9 CN(C)C1CCN(CCc2c(/C=C/c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
44296729 108349 0 None - 1 Human 5.9 pKi = 5.9 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 328 3 2 6 2.5 Nc1ccc([S+]([O-])c2cc(N)c3ncccc3c2[N+](=O)[O-])cc1 10.1016/0960-894X(96)00319-8
CHEMBL298542 108349 0 None - 1 Human 5.9 pKi = 5.9 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 328 3 2 6 2.5 Nc1ccc([S+]([O-])c2cc(N)c3ncccc3c2[N+](=O)[O-])cc1 10.1016/0960-894X(96)00319-8
46879606 12732 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 398 6 2 7 4.9 COc1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1079917 12732 0 None - 1 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 398 6 2 7 4.9 COc1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL4289021 220262 0 None -51 4 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4294418 220310 0 None -1000 4 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)[C@@H](C)O)C(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC1=O 10.1021/acs.jmedchem.8b01046
44362626 43877 0 None - 1 Human 5.9 pKi = 5.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 394 7 0 4 5.0 CN(C)C1CCN(CCc2c(COc3ccccc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145248 43877 0 None - 1 Human 5.9 pKi = 5.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 394 7 0 4 5.0 CN(C)C1CCN(CCc2c(COc3ccccc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
10692519 23236 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 402 5 0 3 6.1 Cn1c(COc2ccc(Cl)cc2Cl)c(CN2CCCCC2)c2ccccc21 10.1021/jm970512x
CHEMBL123410 23236 0 None - 1 Human 5.9 pKi = 5.9 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 402 5 0 3 6.1 Cn1c(COc2ccc(Cl)cc2Cl)c(CN2CCCCC2)c2ccccc21 10.1021/jm970512x
44362766 126006 0 None - 1 Human 4.9 pKi = 4.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 459 6 0 4 6.5 CN(C)C1CCN(CCc2c(/C=N/c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL343413 126006 0 None - 1 Human 4.9 pKi = 4.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 459 6 0 4 6.5 CN(C)C1CCN(CCc2c(/C=N/c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL592149 222586 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL None None None None 10.1016/j.bmcl.2009.12.068
11799055 213995 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 369 6 1 4 4.7 Clc1ccc(OCc2nc3ccccc3n2CCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL92685 213995 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 369 6 1 4 4.7 Clc1ccc(OCc2nc3ccccc3n2CCC2CCCNC2)cc1 10.1021/jm9706630
19426753 196559 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 357 4 1 6 3.1 CCc1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+](=O)[O-] 10.1016/0960-894X(96)00319-8
CHEMBL51611 196559 0 None - 1 Human 6.9 pKi = 6.9 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 357 4 1 6 3.1 CCc1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+](=O)[O-] 10.1016/0960-894X(96)00319-8
44324723 85088 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 794 14 2 8 10.7 Cc1ccc2c(c1)nc(COc1ccc(Cl)cc1)n2CCCC1CCCNC1.Cc1ccc2nc(COc3ccc(Cl)cc3)n(CCCC3CCCNC3)c2c1 10.1021/jm9706630
CHEMBL210900 85088 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 794 14 2 8 10.7 Cc1ccc2c(c1)nc(COc1ccc(Cl)cc1)n2CCCC1CCCNC1.Cc1ccc2nc(COc3ccc(Cl)cc3)n(CCCC3CCCNC3)c2c1 10.1021/jm9706630
21336507 196471 0 None -1288 2 Human 4.9 pKi = 4.9 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 490 8 2 3 5.7 O=S(=O)(NC[C@H]1CC[C@H](CNCc2ccc3ccccc3c2)CC1)c1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00287-1
CHEMBL51542 196471 0 None -1288 2 Human 4.9 pKi = 4.9 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 490 8 2 3 5.7 O=S(=O)(NC[C@H]1CC[C@H](CNCc2ccc3ccccc3c2)CC1)c1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00287-1
44363000 43489 0 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 497 7 0 5 5.7 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3C#N)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL144935 43489 0 None - 1 Human 7.9 pKi = 7.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 497 7 0 5 5.7 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3C#N)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL4287140 220247 0 None -8 4 Human 7.9 pKi = 7.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
54583330 69945 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 906 21 5 7 6.0 Cc1ccc(/C=C/c2cc3c4c(c2)CCCN4CCC3)c(C)[n+]1CCOCCOCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774214 69945 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 906 21 5 7 6.0 Cc1ccc(/C=C/c2cc3c4c(c2)CCCN4CCC3)c(C)[n+]1CCOCCOCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789823 69945 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 906 21 5 7 6.0 Cc1ccc(/C=C/c2cc3c4c(c2)CCCN4CCC3)c(C)[n+]1CCOCCOCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
11800628 119117 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 541 6 4 4 6.1 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4sccc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL329366 119117 0 None - 1 Human 7.9 pKi = 7.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 541 6 4 4 6.1 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4sccc4c3)CCc3ccccc32)c1 10.1021/jm990044m
54585271 69896 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1098 29 6 8 9.1 Cc1cc(/C=C\C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774342 69896 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1098 29 6 8 9.1 Cc1cc(/C=C\C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789354 69896 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1098 29 6 8 9.1 Cc1cc(/C=C\C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
54583332 69920 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1070 27 6 8 8.3 Cc1cc(/C=C/C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774220 69920 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1070 27 6 8 8.3 Cc1cc(/C=C/C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789557 69920 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1070 27 6 8 8.3 Cc1cc(/C=C/C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
49865812 22928 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 699 21 8 7 3.1 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCCCCC(=O)NCCC(N)=O 10.1016/j.bmc.2010.07.028
CHEMBL1224000 22928 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 699 21 8 7 3.1 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCCCCC(=O)NCCC(N)=O 10.1016/j.bmc.2010.07.028
72205486 109327 0 None 29 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 689 20 9 7 1.2 N=C(N)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440937 109327 0 None 29 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 689 20 9 7 1.2 N=C(N)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040689 109327 0 None 29 2 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 689 20 9 7 1.2 N=C(N)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2370633 216679 0 None -426 2 Human 6.9 pKi = 6.9 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CNC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CNC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCC(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
CHEMBL4289021 220262 0 None -51 4 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4294418 220310 0 None -1000 4 Human 5.9 pKi = 5.9 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)[C@@H](C)O)C(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC1=O 10.1021/acs.jmedchem.8b01046
44362637 44116 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 522 9 0 5 6.1 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CC(=O)N2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL145438 44116 0 None - 1 Human 6.9 pKi = 6.9 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 522 9 0 5 6.1 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CC(=O)N2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL3349038 218185 0 None -6 2 Human 7.9 pKi = 7.9 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
72205671 109328 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 657 19 9 6 1.5 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CN)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440919 109328 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 657 19 9 6 1.5 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CN)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040694 109328 0 None - 1 Human 7.9 pKi = 7.9 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 657 19 9 6 1.5 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CN)cc1 10.1016/j.bmc.2013.08.065
1485 7418 31 None 1 4 Human 7.8 pKi = 7.8 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/s0960-894x(01)00761-2
3474 7418 31 None 1 4 Human 7.8 pKi = 7.8 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/s0960-894x(01)00761-2
5311023 7418 31 None 1 4 Human 7.8 pKi = 7.8 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/s0960-894x(01)00761-2
CHEMBL332347 7418 31 None 1 4 Human 7.8 pKi = 7.8 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/s0960-894x(01)00761-2
44362574 40747 0 None - 1 Human 6.9 pKi = 6.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 462 7 0 4 6.4 CN(C)C1CCN(CCc2c(COc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL142427 40747 0 None - 1 Human 6.9 pKi = 6.9 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 462 7 0 4 6.4 CN(C)C1CCN(CCc2c(COc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL2371909 216928 0 None -33 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
CHEMBL2371910 216929 0 None -31 3 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
54587223 69935 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 875 18 6 5 7.0 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774215 69935 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 875 18 6 5 7.0 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789787 69935 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 875 18 6 5 7.0 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
10529375 213314 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 499 5 4 3 5.3 CC(C)(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL88576 213314 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 499 5 4 3 5.3 CC(C)(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
11800499 213362 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 536 6 4 4 5.4 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3cnc4ccccc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL88871 213362 0 None - 1 Human 6.9 pKi = 6.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 536 6 4 4 5.4 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3cnc4ccccc4c3)CCc3ccccc32)c1 10.1021/jm990044m
155561620 182429 0 None -117 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1590 51 25 19 -1.2 CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4581256 182429 0 None -117 3 Human 5.9 pKi = 5.9 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1590 51 25 19 -1.2 CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
10696695 113511 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 499 7 4 3 5.1 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(CNC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314425 113511 0 None - 1 Human 5.9 pKi = 5.9 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 499 7 4 3 5.1 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(CNC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
54583519 68422 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 491 7 2 7 5.3 COc1cc(Cl)c(-c2c(C)nn3c(NCC(C)(C)NC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771263 68422 0 None - 1 Human 6.9 pKi = 6.9 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 491 7 2 7 5.3 COc1cc(Cl)c(-c2c(C)nn3c(NCC(C)(C)NC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL2110196 215991 0 None 4 2 Human 6.8 pKi = 6.8 Binding
Compound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cellsCompound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm950811r
21336503 197848 0 None -549 2 Human 4.8 pKi = 4.8 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 490 8 2 3 5.7 O=S(=O)(NC[C@H]1CC[C@H](CNCc2cccc3ccccc23)CC1)c1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00287-1
CHEMBL51874 197848 0 None -549 2 Human 4.8 pKi = 4.8 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 490 8 2 3 5.7 O=S(=O)(NC[C@H]1CC[C@H](CNCc2cccc3ccccc23)CC1)c1ccccc1C(F)(F)F 10.1016/s0960-894x(02)00287-1
10458754 43640 0 None - 1 Human 7.8 pKi = 7.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 502 8 1 5 5.3 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3CO)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145056 43640 0 None - 1 Human 7.8 pKi = 7.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 502 8 1 5 5.3 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3CO)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL3349022 218183 0 None -3 2 Human 7.8 pKi = 7.8 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
45269317 203060 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 519 7 1 4 5.2 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N(C)C)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL562000 203060 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 519 7 1 4 5.2 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N(C)C)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
70686176 82374 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 486 13 5 4 3.9 N=C(N)NCCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)CCc1ccc(O)cc1 10.1021/ml200265m
CHEMBL2046865 82374 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation countingDisplacement of [125I]peptideYY from NPY1 receptor in human SK-N-MC cells after 1 hr by scintillation counting
ChEMBL 486 13 5 4 3.9 N=C(N)NCCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)CCc1ccc(O)cc1 10.1021/ml200265m
10625155 119347 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 498 6 4 3 4.8 C/N=C(/Nc1ccccc1)NC1CCc2ccccc2N(Cc2cccc(NC(=O)NC(C)C)c2)C1=O 10.1021/jm990044m
CHEMBL330095 119347 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 498 6 4 3 4.8 C/N=C(/Nc1ccccc1)NC1CCc2ccccc2N(Cc2cccc(NC(=O)NC(C)C)c2)C1=O 10.1021/jm990044m
45270153 202254 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 559 7 1 4 6.1 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL552762 202254 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 559 7 1 4 6.1 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
54582348 69934 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 849 20 6 5 6.9 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774218 69934 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 849 20 6 5 6.9 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789785 69934 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 849 20 6 5 6.9 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
10624998 213624 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 493 6 4 6 3.7 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3nncs3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL90560 213624 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 493 6 4 6 3.7 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3nncs3)CCc3ccccc32)c1 10.1021/jm990044m
49865799 22915 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 830 29 6 5 10.2 CCCCCCCCCCCCC#CC#CCCCCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
CHEMBL1223986 22915 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 830 29 6 5 10.2 CCCCCCCCCCCCC#CC#CCCCCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
10842778 118404 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCCC4CCNCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL328460 118404 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCCC4CCNCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
46879650 13058 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 382 6 2 6 5.2 CC[C@@H]1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1081733 13058 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 382 6 2 6 5.2 CC[C@@H]1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL4294277 220309 0 None -63 4 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4283846 220222 0 None -39 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CO)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
10605125 214112 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.4 Clc1ccc(OCc2nc3c(OCCCC4CCCCN4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL93535 214112 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.4 Clc1ccc(OCc2nc3c(OCCCC4CCCCN4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
91928728 217504 17 None -7 2 Human 7.8 pKi = 7.8 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00027
CHEMBL267633 217504 17 None -7 2 Human 7.8 pKi = 7.8 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.0c00027
44362801 42720 0 None - 1 Human 6.8 pKi = 6.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 472 7 0 4 5.8 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL144262 42720 0 None - 1 Human 6.8 pKi = 6.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 472 7 0 4 5.8 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL3349022 218183 0 None -3 2 Human 6.8 pKi = 6.8 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL4294277 220309 0 None -63 4 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
45267593 203479 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 515 6 1 3 5.7 C[C@@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)C(C)(C)C1)c1ccccc1 10.1016/j.bmcl.2009.06.050
CHEMBL564810 203479 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 515 6 1 3 5.7 C[C@@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)C(C)(C)C1)c1ccccc1 10.1016/j.bmcl.2009.06.050
10505296 213296 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 492 6 4 5 4.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3nccs3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL88450 213296 0 None - 1 Human 6.8 pKi = 6.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 492 6 4 5 4.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3nccs3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL266730 217475 0 None -51 2 Human 6.8 pKi = 6.8 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None None 10.1021/jm00055a010
CHEMBL4283846 220222 0 None -39 4 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CO)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
155547323 180405 0 None -144 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1590 51 25 19 -1.2 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4533775 180405 0 None -144 3 Human 5.8 pKi = 5.8 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1590 51 25 19 -1.2 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
9982218 108541 6 None -2041 6 Human 4.8 pKi = 4.8 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 471 9 2 5 4.1 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL1435188 108541 6 None -2041 6 Human 4.8 pKi = 4.8 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 471 9 2 5 4.1 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL299879 108541 6 None -2041 6 Human 4.8 pKi = 4.8 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 471 9 2 5 4.1 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1 10.1016/s0960-894x(02)00287-1
21188477 44902 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 483 11 1 5 5.9 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCC(=O)O)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL146116 44902 0 None - 1 Human 5.8 pKi = 5.8 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 483 11 1 5 5.9 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCC(=O)O)CC1 10.1016/s0960-894x(98)00048-1
46879456 12678 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 384 6 2 7 4.5 COc1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1079609 12678 0 None - 1 Human 5.8 pKi = 5.8 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 384 6 2 7 4.5 COc1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
10625949 113325 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 526 6 4 5 5.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ocnc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314123 113325 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 526 6 4 5 5.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ocnc4c3)CCc3ccccc32)c1 10.1021/jm990044m
10649777 212969 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 525 6 4 3 5.4 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)CCC4)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL86433 212969 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 525 6 4 3 5.4 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)CCC4)CCc3ccccc32)c1 10.1021/jm990044m
10509290 213656 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCC[C@@H]4CCCNC4)cccc3n2CCC[C@H]2CCCNC2)cc1 10.1021/jm9706630
CHEMBL90717 213656 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCC[C@@H]4CCCNC4)cccc3n2CCC[C@H]2CCCNC2)cc1 10.1021/jm9706630
44362838 44192 0 None - 1 Human 5.8 pKi = 5.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 461 7 1 4 6.4 CN(C)C1CCN(CCc2c(CNc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145501 44192 0 None - 1 Human 5.8 pKi = 5.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 461 7 1 4 6.4 CN(C)C1CCN(CCc2c(CNc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
44362997 128760 0 None - 1 Human 5.8 pKi = 5.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 476 7 0 4 6.9 CC(Oc1ccc(Cl)cc1Cl)c1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL359207 128760 0 None - 1 Human 5.8 pKi = 5.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 476 7 0 4 6.9 CC(Oc1ccc(Cl)cc1Cl)c1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
21336489 86271 0 None -1737 2 Human 4.8 pKi = 4.8 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 441 8 3 4 3.7 Nc1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL2113711 86271 0 None -1737 2 Human 4.8 pKi = 4.8 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 441 8 3 4 3.7 Nc1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1 10.1016/s0960-894x(02)00287-1
44362506 43662 0 None - 1 Human 6.8 pKi = 6.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 515 8 1 5 4.9 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3C(N)=O)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145078 43662 0 None - 1 Human 6.8 pKi = 6.8 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 515 8 1 5 4.9 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3C(N)=O)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
46879693 12734 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 430 6 2 6 6.2 c1ccc([C@@H]2CSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL1079927 12734 0 None - 1 Human 6.8 pKi = 6.8 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 430 6 2 6 6.2 c1ccc([C@@H]2CSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
15383696 201580 0 None - 1 Human 5.8 pKi = 5.8 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 363 3 1 6 3.2 Nc1cc(S(=O)(=O)c2ccc(Cl)cc2)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
CHEMBL53876 201580 0 None - 1 Human 5.8 pKi = 5.8 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 363 3 1 6 3.2 Nc1cc(S(=O)(=O)c2ccc(Cl)cc2)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
45269306 202968 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 6.1 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(N4CCCCC4=O)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL561392 202968 0 None - 1 Human 7.8 pKi = 7.8 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 6.1 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(N4CCCCC4=O)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
10626335 119334 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 543 6 4 5 4.7 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)OCCO4)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL329997 119334 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 543 6 4 5 4.7 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)OCCO4)CCc3ccccc32)c1 10.1021/jm990044m
10577995 174880 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 524 6 5 3 5.4 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4[nH]ccc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL432766 174880 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 524 6 5 3 5.4 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4[nH]ccc4c3)CCc3ccccc32)c1 10.1021/jm990044m
10795082 214091 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 510 11 2 6 5.8 Clc1ccc(OCc2nc3c(OCCC4CCCNC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL93375 214091 0 None - 1 Human 7.8 pKi = 7.8 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 510 11 2 6 5.8 Clc1ccc(OCc2nc3c(OCCC4CCCNC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
44351121 165769 0 None -6 2 Human 7.8 pKi = 7.8 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 91 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
91929374 165769 0 None -6 2 Human 7.8 pKi = 7.8 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 91 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
CHEMBL409634 165769 0 None -6 2 Human 7.8 pKi = 7.8 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 91 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
2317 74423 9 None 2 2 Human 5.8 pKi = 5.8 Binding
Binding affinity to NPY1 receptorBinding affinity to NPY1 receptor
ChEMBL 590 27 4 8 6.3 COc1ccccc1CNCCCCCCNCCSSCCNCCCCCCNCc1ccccc1OC 10.1016/j.bmcl.2011.06.124
CHEMBL19060 74423 9 None 2 2 Human 5.8 pKi = 5.8 Binding
Binding affinity to NPY1 receptorBinding affinity to NPY1 receptor
ChEMBL 590 27 4 8 6.3 COc1ccccc1CNCCCCCCNCCSSCCNCCCCCCNCc1ccccc1OC 10.1016/j.bmcl.2011.06.124
CHEMBL340824 124929 0 None - 1 Human 6.7 pKi = 6.7 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 636 10 3 7 7.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3cccc(-c4ccccc4)c3)CC2)c1 10.1016/s0960-894x(01)00761-2
CHEMBL3349022 218183 0 None -3 2 Human 7.7 pKi = 7.7 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
54587217 68741 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 586 16 6 5 3.1 NCCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774205 68741 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 586 16 6 5 3.1 NCCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
44362862 126002 0 None - 1 Human 6.7 pKi = 6.7 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 502 8 1 5 5.3 CN(C)C1CCN(CCc2c(COc3ccc(CO)cc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL343399 126002 0 None - 1 Human 6.7 pKi = 6.7 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 502 8 1 5 5.3 CN(C)C1CCN(CCc2c(COc3ccc(CO)cc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
44362821 41517 0 None - 1 Human 5.7 pKi = 5.7 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 385 6 0 3 6.2 Clc1ccc(OCc2sc3ccccc3c2CCN2CCCCC2)cc1 10.1016/s0960-894x(99)00019-0
CHEMBL143068 41517 0 None - 1 Human 5.7 pKi = 5.7 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 385 6 0 3 6.2 Clc1ccc(OCc2sc3ccccc3c2CCN2CCCCC2)cc1 10.1016/s0960-894x(99)00019-0
46879779 12790 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 472 8 2 6 6.9 c1ccc(CCC2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL1080301 12790 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 472 8 2 6 6.9 c1ccc(CCC2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL4283705 220220 0 None -1 4 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4282216 220209 0 None -316 4 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CN(C(=N)N)C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
91928728 217504 17 None -7 2 Human 8.7 pKi = 8.7 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL267633 217504 17 None -7 2 Human 8.7 pKi = 8.7 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL3349022 218183 0 None -3 2 Human 8.7 pKi = 8.7 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
10414488 209458 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity at cloned Neuropeptide Y receptor type 1 expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y receptor type 1 expressed in AV-12 cells is evaluated.
ChEMBL 524 12 1 6 6.3 Clc1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1016/s0960-894x(98)00048-1
CHEMBL61532 209458 0 None - 1 Human 8.7 pKi = 8.7 Binding
Binding affinity at cloned Neuropeptide Y receptor type 1 expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y receptor type 1 expressed in AV-12 cells is evaluated.
ChEMBL 524 12 1 6 6.3 Clc1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1016/s0960-894x(98)00048-1
1485 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
3474 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
5311023 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
CHEMBL332347 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm801018u
1505 9656 0 None -6 4 Human 8.7 pKi = 8.7 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None None 10.1021/jm00055a010
CHEMBL441396 9656 0 None -6 4 Human 8.7 pKi = 8.7 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None None 10.1021/jm00055a010
44283143 168477 0 None 28 4 Human 8.6 pKi = 8.6 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL 2361 75 32 32 -6.3 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CSSC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm010031k
91931648 168477 0 None 28 4 Human 8.6 pKi = 8.6 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL 2361 75 32 32 -6.3 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CSSC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm010031k
CHEMBL413455 168477 0 None 28 4 Human 8.6 pKi = 8.6 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL 2361 75 32 32 -6.3 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CSSC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm010031k
155563387 182096 0 None 269 2 Human 8.6 pKi = 8.6 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2259 56 35 29 -7.7 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4573545 182096 0 None 269 2 Human 8.6 pKi = 8.6 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2259 56 35 29 -7.7 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL126618 24836 0 None - 1 Human 8.6 pKi = 8.6 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 576 9 4 8 5.2 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3cccc(O)c3)CC2)c1 10.1016/s0960-894x(01)00761-2
CHEMBL437863 220516 0 None -3 2 Human 8.5 pKi = 8.5 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
10767712 118377 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 500 6 5 4 4.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(/N=C(\N)Nc3ccc(O)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL328288 118377 0 None - 1 Human 8.5 pKi = 8.5 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 500 6 5 4 4.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(/N=C(\N)Nc3ccc(O)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL4283705 220220 0 None -1 4 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
72205482 109324 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 671 19 8 5 2.7 NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440935 109324 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 671 19 8 5 2.7 NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040670 109324 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 671 19 8 5 2.7 NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440898 217743 0 None 10 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CNC(=O)CCC(=O)NCCN(CCN)CCNC(=O)CCC(=O)NCC(=O)NCCCCNC(=O)NCc2ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c3ccccc3)c3ccccc3)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040691 217743 0 None 10 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CNC(=O)CCC(=O)NCCN(CCN)CCNC(=O)CCC(=O)NCC(=O)NCCCCNC(=O)NCc2ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c3ccccc3)c3ccccc3)cc2)cc1 10.1016/j.bmc.2013.08.065
10625207 213350 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 500 6 5 4 4.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(N)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL88805 213350 0 None - 1 Human 6.7 pKi = 6.7 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 500 6 5 4 4.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(N)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL4282216 220209 0 None -316 4 Human 5.7 pKi = 5.7 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CN(C(=N)N)C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
21188661 44062 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 550 11 0 5 6.9 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCC(=O)N2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL145396 44062 0 None - 1 Human 7.7 pKi = 7.7 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 550 11 0 5 6.9 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCC(=O)N2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL5282574 200939 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assayDisplacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assay
ChEMBL 628 12 3 11 3.9 COC(=O)C1=CNC(C)=C(C(=O)OC)C1c1cccc(Nc2c(NCCCN3CCC(c4cccc(OC)c4)CC3)c(=O)c2=O)c1 10.1039/D1MD00058F
9908496 68415 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 391 6 2 5 4.9 Cc1cc(C)c(-c2c(C)nn3c(NCCNC4CCCC4)cc(C)nc23)c(C)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771256 68415 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 391 6 2 5 4.9 Cc1cc(C)c(-c2c(C)nn3c(NCCNC4CCCC4)cc(C)nc23)c(C)c1 10.1016/j.bmcl.2010.12.116
CHEMBL439904 220633 13 None -52 3 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]PYY from NPY1 receptor expressed in human SK-N-MC cellsDisplacement of [125I]PYY from NPY1 receptor expressed in human SK-N-MC cells
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1016/j.bmcl.2006.10.007
CHEMBL3349022 218183 0 None -3 2 Human 6.7 pKi = 6.7 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL428017 220181 17 None -41 2 Human 6.7 pKi = 6.7 Binding
Binding affinity to NPYY1 receptor (unknown origin)Binding affinity to NPYY1 receptor (unknown origin)
ChEMBL None None None CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1016/j.bmcl.2013.11.061
CHEMBL428017 220181 17 None -41 2 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]PYY from human NPY1 receptor in SK-N-MC cellsDisplacement of [125I]PYY from human NPY1 receptor in SK-N-MC cells
ChEMBL None None None CC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1016/j.bmcl.2007.01.045
45268477 203144 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 5.7 COc1cccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)c1 10.1016/j.bmcl.2009.06.050
CHEMBL562532 203144 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 5.7 COc1cccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)c1 10.1016/j.bmcl.2009.06.050
CHEMBL2440911 217750 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040758 217750 0 None 1 3 Human 6.7 pKi = 6.7 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL411979 219746 0 None -83 2 Human 6.7 pKi = 6.7 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N)Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@H](C)CC 10.1021/jm00055a010
11799136 113331 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 3 4 4.9 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Oc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314169 113331 0 None - 1 Human 5.7 pKi = 5.7 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 3 4 4.9 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Oc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
162651028 190430 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 683 16 7 5 3.8 N/C(=N/C(=O)NCCNC(=O)CC1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4750988 190430 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 683 16 7 5 3.8 N/C(=N/C(=O)NCCNC(=O)CC1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802711 190430 0 None - 1 Human 5.7 pKi = 5.7 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 683 16 7 5 3.8 N/C(=N/C(=O)NCCNC(=O)CC1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44362526 126188 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 455 9 1 5 5.2 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CC(=O)O)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL344722 126188 0 None - 1 Human 5.7 pKi = 5.7 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 455 9 1 5 5.2 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CC(=O)O)CC1 10.1016/s0960-894x(98)00048-1
54587431 68424 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 425 8 2 6 4.3 COc1cc(Cl)c(-c2c(C)nn3c(NCCNCCF)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771265 68424 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 425 8 2 6 4.3 COc1cc(Cl)c(-c2c(C)nn3c(NCCNCCF)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
44517723 201661 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 581 8 1 4 6.0 COc1ccc([C@H](N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)C(F)F)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL540466 201661 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 581 8 1 4 6.0 COc1ccc([C@H](N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)C(F)F)cc1 10.1016/j.bmcl.2009.06.050
52953218 69928 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 918 20 6 6 6.3 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774211 69928 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 918 20 6 6 6.3 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789734 69928 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 918 20 6 6 6.3 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
52953218 69928 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometryDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometry
ChEMBL 918 20 6 6 6.3 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774211 69928 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometryDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometry
ChEMBL 918 20 6 6 6.3 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789734 69928 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometryDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometry
ChEMBL 918 20 6 6 6.3 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
127041328 143910 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 559 13 7 5 1.7 NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746864 143910 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 559 13 7 5 1.7 NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747821 143910 0 None - 1 Human 7.7 pKi = 7.7 Binding
Displacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK136 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 559 13 7 5 1.7 NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
44351146 175991 0 None -3 2 Human 7.7 pKi = 7.7 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 89 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
91929377 175991 0 None -3 2 Human 7.7 pKi = 7.7 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 89 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
CHEMBL440824 175991 0 None -3 2 Human 7.7 pKi = 7.7 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 89 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
CHEMBL408891 219517 0 None -41 3 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
CHEMBL2370624 216671 0 None -95 2 Human 6.7 pKi = 6.7 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CNC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCC(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
46879560 13126 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 368 5 2 6 4.9 c1ccc2sc(NCCc3ccc(NC4=NCCCS4)cc3)nc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1082083 13126 0 None - 1 Human 6.7 pKi = 6.7 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 368 5 2 6 4.9 c1ccc2sc(NCCc3ccc(NC4=NCCCS4)cc3)nc2c1 10.1016/j.bmcl.2009.09.048
54587219 69929 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 931 21 6 5 7.0 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774210 69929 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 931 21 6 5 7.0 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789738 69929 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 931 21 6 5 7.0 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL2440899 217749 0 None -2 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)CC1(CC(=O)N2CCN(C3c4ccccc4NC(=O)c4ccccc43)CC2)CCCC1)C(=O)NCCn1c(=O)n(-c2ccccc2)n(-c2ccccc2)c1=O)CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040747 217749 0 None -2 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)CC1(CC(=O)N2CCN(C3c4ccccc4NC(=O)c4ccccc43)CC2)CCCC1)C(=O)NCCn1c(=O)n(-c2ccccc2)n(-c2ccccc2)c1=O)CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440911 217750 0 None 1 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040758 217750 0 None 1 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2370634 216680 0 None -208 2 Human 6.6 pKi = 6.6 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CNC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCC(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
44363007 43876 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 475 6 1 4 6.0 CN(C)C1CCN(CCc2c(C(=O)Nc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145243 43876 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 475 6 1 4 6.0 CN(C)C1CCN(CCc2c(C(=O)Nc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
22617869 68413 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 323 4 2 5 3.3 Cc1cc(C)c(-c2c(C)nn3c(NCCN)cc(C)nc23)c(C)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771254 68413 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 323 4 2 5 3.3 Cc1cc(C)c(-c2c(C)nn3c(NCCN)cc(C)nc23)c(C)c1 10.1016/j.bmcl.2010.12.116
10619067 171358 0 None - 1 Human 5.6 pKi = 5.6 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 368 5 0 3 5.4 Cn1c(COc2ccc(Cl)cc2)c(CN2CCCCC2)c2ccccc21 10.1021/jm9706630
CHEMBL421549 171358 0 None - 1 Human 5.6 pKi = 5.6 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 368 5 0 3 5.4 Cn1c(COc2ccc(Cl)cc2)c(CN2CCCCC2)c2ccccc21 10.1021/jm9706630
1485 7418 31 None 1 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm970512x
3474 7418 31 None 1 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm970512x
5311023 7418 31 None 1 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm970512x
CHEMBL332347 7418 31 None 1 4 Human 5.6 pKi = 5.6 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1021/jm970512x
10619067 171358 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 368 5 0 3 5.4 Cn1c(COc2ccc(Cl)cc2)c(CN2CCCCC2)c2ccccc21 10.1021/jm970512x
CHEMBL421549 171358 0 None - 1 Human 5.6 pKi = 5.6 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 368 5 0 3 5.4 Cn1c(COc2ccc(Cl)cc2)c(CN2CCCCC2)c2ccccc21 10.1021/jm970512x
19426744 201504 0 None - 1 Human 6.6 pKi = 6.6 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 407 3 1 6 3.3 Nc1cc(S(=O)(=O)c2ccccc2Br)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
CHEMBL53497 201504 0 None - 1 Human 6.6 pKi = 6.6 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 407 3 1 6 3.3 Nc1cc(S(=O)(=O)c2ccccc2Br)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
21336493 195986 0 None -1698 2 Human 4.6 pKi = 4.6 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 468 9 2 6 4.0 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCc2ccc3ccccc3n2)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL51138 195986 0 None -1698 2 Human 4.6 pKi = 4.6 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 468 9 2 6 4.0 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCc2ccc3ccccc3n2)CC1 10.1016/s0960-894x(02)00287-1
45271821 66248 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 555 8 1 5 6.6 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccc(OC)nc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL171377 66248 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 555 8 1 5 6.6 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccc(OC)nc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
54584290 69891 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 880 23 5 7 6.0 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCOCCOCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774217 69891 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 880 23 5 7 6.0 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCOCCOCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789346 69891 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 880 23 5 7 6.0 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCOCCOCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL2440914 217748 0 None 8 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040731 217748 0 None 8 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
10674056 212771 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 542 6 4 5 5.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4scnc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL84793 212771 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 542 6 4 5 5.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4scnc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL263848 217371 0 None -16 2 Human 7.6 pKi = 7.6 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CSSC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N)Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
10600984 112797 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 4 4 4.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccn3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL313292 112797 0 None - 1 Human 6.6 pKi = 6.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 4 4 4.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccn3)CCc3ccccc32)c1 10.1021/jm990044m
44362444 43926 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 436 7 0 4 6.0 Cc1cc(C)c(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)c(C)c1 10.1016/s0960-894x(99)00019-0
CHEMBL145289 43926 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 436 7 0 4 6.0 Cc1cc(C)c(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)c(C)c1 10.1016/s0960-894x(99)00019-0
44362459 125547 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 529 9 0 5 5.9 CN(C)Cc1cc(Br)ccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL341908 125547 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 529 9 0 5 5.9 CN(C)Cc1cc(Br)ccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
46880224 13004 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 354 5 2 6 4.5 c1ccc2sc(NCCc3ccc(NC4=NCCS4)cc3)nc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1081469 13004 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 354 5 2 6 4.5 c1ccc2sc(NCCc3ccc(NC4=NCCS4)cc3)nc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL2440927 217751 0 None 15 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040781 217751 0 None 15 3 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
10816575 213057 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 554 6 5 5 3.8 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)C(=O)NC4=O)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL86952 213057 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 554 6 5 5 3.8 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)C(=O)NC4=O)CCc3ccccc32)c1 10.1021/jm990044m
155533017 178589 0 None 6 2 Human 7.6 pKi = 7.6 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2435 58 36 30 -4.4 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4468261 178589 0 None 6 2 Human 7.6 pKi = 7.6 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2435 58 36 30 -4.4 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NCCCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL438914 220586 16 None 54 4 Human 7.6 pKi = 7.6 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC)[C@@H](C)CC 10.1021/jm010031k
CHEMBL4290445 220274 0 None -3981 4 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4290615 220276 0 None -12 4 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4290445 220274 0 None -3981 4 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4290615 220276 0 None -12 4 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
46879737 12784 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 384 6 2 7 4.4 COC1CN=C(Nc2ccc(CCNc3nc4ccccc4s3)cc2)S1 10.1016/j.bmcl.2009.09.048
CHEMBL1080289 12784 0 None - 1 Human 5.6 pKi = 5.6 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 384 6 2 7 4.4 COC1CN=C(Nc2ccc(CCNc3nc4ccccc4s3)cc2)S1 10.1016/j.bmcl.2009.09.048
10672357 23533 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 479 7 0 5 5.5 Cn1c(COc2ccc(Cl)cc2)c(C(=O)CN2CCC(N3CCCCC3)CC2)c2ccccc21 10.1021/jm970512x
CHEMBL124343 23533 0 None - 1 Human 7.6 pKi = 7.6 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 479 7 0 5 5.5 Cn1c(COc2ccc(Cl)cc2)c(C(=O)CN2CCC(N3CCCCC3)CC2)c2ccccc21 10.1021/jm970512x
52953220 69927 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774344 69927 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789732 69927 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
52953220 69927 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometryDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometry
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774344 69927 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometryDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometry
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789732 69927 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometryDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells by flow cytometry
ChEMBL 962 24 7 7 7.4 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
10554097 113780 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 525 6 5 4 4.8 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4[nH]ncc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL315299 113780 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 525 6 5 4 4.8 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4[nH]ncc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL3349341 218187 0 None -72 2 Human 6.6 pKi = 6.6 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
44362542 127802 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 536 10 0 5 6.5 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(C(=O)CCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL356585 127802 0 None - 1 Human 6.6 pKi = 6.6 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 536 10 0 5 6.5 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(C(=O)CCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
49865807 22922 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 714 21 7 8 3.8 COC(=O)CCNC(=O)CCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
CHEMBL1223995 22922 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 714 21 7 8 3.8 COC(=O)CCNC(=O)CCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
CHEMBL2440899 217749 0 None -2 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)CC1(CC(=O)N2CCN(C3c4ccccc4NC(=O)c4ccccc43)CC2)CCCC1)C(=O)NCCn1c(=O)n(-c2ccccc2)n(-c2ccccc2)c1=O)CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040747 217749 0 None -2 3 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)CC1(CC(=O)N2CCN(C3c4ccccc4NC(=O)c4ccccc43)CC2)CCCC1)C(=O)NCCn1c(=O)n(-c2ccccc2)n(-c2ccccc2)c1=O)CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
44362811 171838 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 399 7 0 3 6.6 Clc1ccc(OCc2sc3ccccc3c2CCCN2CCCCC2)cc1 10.1016/s0960-894x(99)00019-0
CHEMBL422655 171838 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 399 7 0 3 6.6 Clc1ccc(OCc2sc3ccccc3c2CCCN2CCCCC2)cc1 10.1016/s0960-894x(99)00019-0
44350924 175767 0 None -58 4 Human 6.6 pKi = 6.6 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
91929378 175767 0 None -58 4 Human 6.6 pKi = 6.6 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
CHEMBL439122 175767 0 None -58 4 Human 6.6 pKi = 6.6 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
45271004 202140 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 549 6 1 3 6.4 C[C@@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)C(C)(C)C1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL551876 202140 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 549 6 1 3 6.4 C[C@@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)C(C)(C)C1)c1ccc(Cl)cc1 10.1016/j.bmcl.2009.06.050
44563342 196427 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 515 13 5 4 3.4 CCC/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL515095 196427 0 None - 1 Human 7.6 pKi = 7.6 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 515 13 5 4 3.4 CCC/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
10676562 118414 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCC[C@H]4CCCNC4)cccc3n2CCC[C@@H]2CCCNC2)cc1 10.1021/jm9706630
CHEMBL328532 118414 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCC[C@H]4CCCNC4)cccc3n2CCC[C@@H]2CCCNC2)cc1 10.1021/jm9706630
49865801 22917 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 743 15 6 5 7.7 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCc1ccc2ccc3cccc4ccc1c2c34 10.1016/j.bmc.2010.07.028
CHEMBL1223988 22917 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 743 15 6 5 7.7 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCc1ccc2ccc3cccc4ccc1c2c34 10.1016/j.bmc.2010.07.028
CHEMBL592104 222584 0 None - 1 Human 6.6 pKi = 6.6 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL None None None CC[C@H](C)[C@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1016/j.bmcl.2009.12.068
44362774 171690 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 422 8 0 5 4.9 CN(C)C1CCN(CCc2c(COc3ccccc3C=O)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL422297 171690 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 422 8 0 5 4.9 CN(C)C1CCN(CCc2c(COc3ccccc3C=O)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
10673757 113662 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 529 6 4 5 4.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)OCO4)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314529 113662 0 None - 1 Human 7.6 pKi = 7.6 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 529 6 4 5 4.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)OCO4)CCc3ccccc32)c1 10.1021/jm990044m
44362627 45507 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 476 8 0 4 6.4 CN(C)C1CCN(CCc2c(CCOc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL146606 45507 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 476 8 0 4 6.4 CN(C)C1CCN(CCc2c(CCOc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL2440194 217262 0 None -3 2 Human 6.6 pKi = 6.6 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None CCCC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/jm4008505
10472655 201349 0 None - 1 Human 6.6 pKi = 6.6 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 344 3 2 7 2.1 Nc1ccc(S(=O)(=O)c2cc(N)c3ncccc3c2[N+](=O)[O-])cc1 10.1016/0960-894X(96)00319-8
CHEMBL53016 201349 0 None - 1 Human 6.6 pKi = 6.6 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 344 3 2 7 2.1 Nc1ccc(S(=O)(=O)c2cc(N)c3ncccc3c2[N+](=O)[O-])cc1 10.1016/0960-894X(96)00319-8
44362868 40093 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 464 7 0 4 6.7 Cc1ccc(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)c(C(C)(C)C)c1 10.1016/s0960-894x(99)00019-0
CHEMBL141879 40093 0 None - 1 Human 5.6 pKi = 5.6 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 464 7 0 4 6.7 Cc1ccc(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)c(C(C)(C)C)c1 10.1016/s0960-894x(99)00019-0
44362387 44473 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 439 9 0 4 6.5 CCCN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc32)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL145761 44473 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 439 9 0 4 6.5 CCCN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc32)CC1 10.1016/s0960-894x(98)00048-1
21188602 171526 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 501 10 0 4 7.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCc2ccccc2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL421770 171526 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 501 10 0 4 7.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCc2ccccc2)CC1 10.1016/s0960-894x(98)00048-1
21188717 172094 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 511 12 0 6 6.4 CCOC(=O)CCCN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc32)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL423383 172094 0 None - 1 Human 7.5 pKi = 7.5 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 511 12 0 6 6.4 CCOC(=O)CCCN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc32)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL2440183 217253 0 None 4 2 Human 7.5 pKi = 7.5 Binding
Binding affinity to Y1 receptor (unknown origin)Binding affinity to Y1 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)[C@H]1C(=O)OC)[C@@H](C)O)[C@@H](C)CC 10.1021/jm4008505
9868731 68414 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 457 9 2 6 5.2 COc1ccc(CCNCCNc2cc(C)nc3c(-c4c(C)cc(C)cc4C)c(C)nn23)cc1 10.1016/j.bmcl.2010.12.116
CHEMBL1771255 68414 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 457 9 2 6 5.2 COc1ccc(CCNCCNc2cc(C)nc3c(-c4c(C)cc(C)cc4C)c(C)nn23)cc1 10.1016/j.bmcl.2010.12.116
45272692 202677 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 525 7 1 4 6.5 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4cccnc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL559045 202677 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 525 7 1 4 6.5 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4cccnc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
54582343 69931 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 875 19 5 5 7.6 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774203 69931 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 875 19 5 5 7.6 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789769 69931 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 875 19 5 5 7.6 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL2440928 217740 0 None 7 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040658 217740 0 None 7 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
10744091 213613 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 503 6 4 3 5.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(F)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL90497 213613 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 503 6 4 3 5.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(F)cc3)CCc3ccccc32)c1 10.1021/jm990044m
10700181 213993 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 510 11 2 6 6.0 Clc1ccc(OCc2nc3c(OCCC4CCCCN4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL92679 213993 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 510 11 2 6 6.0 Clc1ccc(OCc2nc3c(OCCC4CCCCN4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
155549336 181042 0 None -102 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1761 57 30 22 -3.5 CCC(=O)N[C@H](CCCC[C@@H](N)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4549208 181042 0 None -102 4 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1761 57 30 22 -3.5 CCC(=O)N[C@H](CCCC[C@@H](N)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCNC(=N)N)C(=O)N[C@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL414051 219885 0 None -323 2 Human 6.5 pKi = 6.5 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
162648914 190420 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 753 17 7 5 4.7 N/C(=N/C(=O)NCCNC(=O)C(c1ccccc1)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4746354 190420 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 753 17 7 5 4.7 N/C(=N/C(=O)NCCNC(=O)C(c1ccccc1)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802592 190420 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 753 17 7 5 4.7 N/C(=N/C(=O)NCCNC(=O)C(c1ccccc1)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
162662291 190493 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 681 15 7 5 3.3 N/C(=N/C(=O)NCCNC(=O)c1ccc(F)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4764296 190493 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 681 15 7 5 3.3 N/C(=N/C(=O)NCCNC(=O)c1ccc(F)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803298 190493 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 681 15 7 5 3.3 N/C(=N/C(=O)NCCNC(=O)c1ccc(F)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
15383694 195915 0 None - 1 Human 6.5 pKi = 6.5 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 329 3 1 6 2.6 Nc1cc(S(=O)(=O)c2ccccc2)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
CHEMBL51065 195915 0 None - 1 Human 6.5 pKi = 6.5 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 329 3 1 6 2.6 Nc1cc(S(=O)(=O)c2ccccc2)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
9869677 68419 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 477 8 2 7 4.9 CCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771260 68419 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 477 8 2 7 4.9 CCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
49865808 22923 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 640 16 7 9 2.3 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCn1cc(CO)nn1 10.1016/j.bmc.2010.07.028
CHEMBL1223996 22923 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 640 16 7 9 2.3 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCn1cc(CO)nn1 10.1016/j.bmc.2010.07.028
CHEMBL604165 222600 0 None -8 3 Human 8.5 pKi = 8.5 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL None None None CSCC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1016/j.bmcl.2009.12.068
127041325 143907 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 714 15 6 8 4.4 [N-]=[N+]=Nc1cccc(-n2cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)c1 10.1021/acs.jmedchem.5b00925
CHEMBL3746893 143907 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 714 15 6 8 4.4 [N-]=[N+]=Nc1cccc(-n2cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)c1 10.1021/acs.jmedchem.5b00925
CHEMBL3747818 143907 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 714 15 6 8 4.4 [N-]=[N+]=Nc1cccc(-n2cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)c1 10.1021/acs.jmedchem.5b00925
9960164 82375 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assayDisplacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assay
ChEMBL 590 10 3 8 4.7 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3cccc(OC)c3)CC2)c1 10.1039/D1MD00058F
CHEMBL2046866 82375 0 None - 1 Human 8.5 pKi = 8.5 Binding
Displacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assayDisplacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assay
ChEMBL 590 10 3 8 4.7 COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3cccc(OC)c3)CC2)c1 10.1039/D1MD00058F
CHEMBL324554 117204 0 None - 1 Human 8.5 pKi = 8.5 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 590 10 3 8 5.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3cccc(OC)c3)CC2)c1 10.1016/s0960-894x(01)00761-2
9869041 68418 12 None -3 2 Rat 8.5 pKi = 8.5 Binding
Displacement of [125]sauvagin from rat recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125]sauvagin from rat recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 463 7 2 7 4.5 COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771259 68418 12 None -3 2 Rat 8.5 pKi = 8.5 Binding
Displacement of [125]sauvagin from rat recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125]sauvagin from rat recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 463 7 2 7 4.5 COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL4290048 220269 0 None -25 4 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL413871 219872 0 None -7 3 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
11640844 12788 0 None 199 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 444 6 2 6 6.6 c1ccc([C@@H]2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL1080298 12788 0 None 199 2 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 444 6 2 6 6.6 c1ccc([C@@H]2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL2440924 217269 0 None 12 3 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
10605127 118415 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCCC4CCCNC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL328541 118415 0 None - 1 Human 7.5 pKi = 7.5 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCCC4CCCNC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
45269310 203003 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 531 7 1 4 6.5 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(N4CCCCC4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL561594 203003 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 531 7 1 4 6.5 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(N4CCCCC4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
162661307 190486 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 677 16 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)Cc1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4765023 190486 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 677 16 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)Cc1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803242 190486 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 677 16 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)Cc1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
72205289 109319 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 703 21 8 7 1.2 NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440932 109319 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 703 21 8 7 1.2 NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040662 109319 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 703 21 8 7 1.2 NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
155564444 182035 0 None 28 2 Human 7.5 pKi = 7.5 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2181 50 30 28 -5.3 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4572358 182035 0 None 28 2 Human 7.5 pKi = 7.5 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2181 50 30 28 -5.3 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
44362820 41449 0 None - 1 Human 6.5 pKi = 6.5 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 428 7 0 4 5.7 CN(C)C1CCN(CCc2c(COc3ccc(Cl)cc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL143014 41449 0 None - 1 Human 6.5 pKi = 6.5 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 428 7 0 4 5.7 CN(C)C1CCN(CCc2c(COc3ccc(Cl)cc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL2440912 217746 0 None -10 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040729 217746 0 None -10 3 Human 5.5 pKi = 5.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
46879646 12269 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 436 5 2 6 6.2 Clc1cc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2cc1Cl 10.1016/j.bmcl.2009.09.048
CHEMBL1076268 12269 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 436 5 2 6 6.2 Clc1cc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2cc1Cl 10.1016/j.bmcl.2009.09.048
46879607 12756 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 386 5 2 6 5.0 Fc1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1080100 12756 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 386 5 2 6 5.0 Fc1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
45270136 202047 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 559 7 1 4 7.2 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccc(Cl)nc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL551206 202047 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 559 7 1 4 7.2 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccc(Cl)nc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL340208 124586 0 None - 1 Human 6.5 pKi = 6.5 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 609 10 3 8 5.5 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccc(Cl)cc3)CC2)c1 10.1016/s0960-894x(01)00761-2
10791454 119345 0 None - 1 Human 5.5 pKi = 5.5 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 383 7 1 4 5.2 Clc1ccc(OCc2nc3ccccc3n2CCCC2CCCCN2)cc1 10.1021/jm9706630
CHEMBL330066 119345 0 None - 1 Human 5.5 pKi = 5.5 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 383 7 1 4 5.2 Clc1ccc(OCc2nc3ccccc3n2CCCC2CCCCN2)cc1 10.1021/jm9706630
21336500 108451 0 None -190 2 Human 5.5 pKi = 5.5 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 500 10 3 4 4.8 O=S(=O)(NC[C@H]1CC[C@H](CNC(CO)Cc2ccc(Cl)cc2)CC1)c1cccc2ccccc12 10.1016/s0960-894x(02)00287-1
CHEMBL299295 108451 0 None -190 2 Human 5.5 pKi = 5.5 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 500 10 3 4 4.8 O=S(=O)(NC[C@H]1CC[C@H](CNC(CO)Cc2ccc(Cl)cc2)CC1)c1cccc2ccccc12 10.1016/s0960-894x(02)00287-1
15338882 185875 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 531 11 5 5 2.8 COC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL471710 185875 0 None - 1 Human 7.5 pKi = 7.5 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 531 11 5 5 2.8 COC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
45269300 202870 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 8 1 6 7.4 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)C3CCC(c4ccccc4)(c4nnc(C)s4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL560795 202870 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 8 1 6 7.4 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)C3CCC(c4ccccc4)(c4nnc(C)s4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL2440917 217738 0 None 9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CCCC(=O)NCCN(CCN)CCNC(=O)CCCC(=O)NCCCCNC(=O)NCc2ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c3ccccc3)c3ccccc3)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040656 217738 0 None 9 2 Human 6.5 pKi = 6.5 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CCCC(=O)NCCN(CCN)CCNC(=O)CCCC(=O)NCCCCNC(=O)NCc2ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c3ccccc3)c3ccccc3)cc2)cc1 10.1016/j.bmc.2013.08.065
46879609 12758 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 413 6 2 8 4.8 O=[N+]([O-])c1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1080102 12758 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 413 6 2 8 4.8 O=[N+]([O-])c1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
46879780 12791 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 450 6 2 6 6.8 c1ccc2sc(NCCc3ccc(NC4=NC(C5CCCCC5)CCS4)cc3)nc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1080302 12791 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 450 6 2 6 6.8 c1ccc2sc(NCCc3ccc(NC4=NC(C5CCCCC5)CCS4)cc3)nc2c1 10.1016/j.bmcl.2009.09.048
15421872 126095 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 397 7 1 4 5.4 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCNCC1 10.1016/s0960-894x(98)00048-1
CHEMBL344096 126095 0 None - 1 Human 6.5 pKi = 6.5 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 397 7 1 4 5.4 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCNCC1 10.1016/s0960-894x(98)00048-1
10820168 103635 0 None 47 4 Human 7.5 pKi = 7.5 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL 1192 37 16 15 -2.3 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)CC 10.1021/jm010031k
CHEMBL265391 103635 0 None 47 4 Human 7.5 pKi = 7.5 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL 1192 37 16 15 -2.3 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)CN[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)CC 10.1021/jm010031k
CHEMBL438548 220555 0 None -4 2 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CSSC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
46879608 12757 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 402 5 2 6 5.5 Clc1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1080101 12757 0 None - 1 Human 6.5 pKi = 6.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 402 5 2 6 5.5 Clc1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
46879453 12647 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 368 5 2 6 4.8 Cc1cccc2sc(NCCc3ccc(NC4=NCCS4)cc3)nc12 10.1016/j.bmcl.2009.09.048
CHEMBL1079440 12647 0 None - 1 Human 5.5 pKi = 5.5 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 368 5 2 6 4.8 Cc1cccc2sc(NCCc3ccc(NC4=NCCS4)cc3)nc12 10.1016/j.bmcl.2009.09.048
21336511 197926 0 None -323 2 Human 5.5 pKi = 5.5 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 476 8 2 3 5.3 O=S(=O)(NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1)c1cccc2ccccc12 10.1016/s0960-894x(02)00287-1
CHEMBL51884 197926 0 None -323 2 Human 5.5 pKi = 5.5 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 476 8 2 3 5.3 O=S(=O)(NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1)c1cccc2ccccc12 10.1016/s0960-894x(02)00287-1
CHEMBL439307 220615 17 None 57 2 Human 7.4 pKi = 7.4 Binding
Compound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cellsCompound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm950811r
10768859 112744 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 542 7 5 4 5.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(/N=C(/Nc3ccc(O)cc3)NC(C)C)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL313007 112744 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 542 7 5 4 5.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(/N=C(/Nc3ccc(O)cc3)NC(C)C)CCc3ccccc32)c1 10.1021/jm990044m
73354090 109347 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 757 21 10 7 0.2 NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440900 109347 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 757 21 10 7 0.2 NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040756 109347 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 757 21 10 7 0.2 NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
127030359 145985 0 None -309 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1845 61 29 21 -1.5 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL3787528 145985 0 None -309 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1845 61 29 21 -1.5 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL3787713 145985 0 None -309 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1845 61 29 21 -1.5 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4535525 145985 0 None -309 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1845 61 29 21 -1.5 CCC(=O)NCCCCNC(=O)/N=C(\N)NCCC[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
44362625 126096 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 628 7 0 4 7.3 CN(C)C1CCN(CCc2c(COc3c(Br)cc(Br)cc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL344101 126096 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 628 7 0 4 7.3 CN(C)C1CCN(CCc2c(COc3c(Br)cc(Br)cc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
46879524 12264 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 422 5 2 6 5.8 Clc1cc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2cc1Cl 10.1016/j.bmcl.2009.09.048
CHEMBL1076234 12264 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 422 5 2 6 5.8 Clc1cc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2cc1Cl 10.1016/j.bmcl.2009.09.048
44362553 125570 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 508 10 0 5 6.6 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL342112 125570 0 None - 1 Human 7.4 pKi = 7.4 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 508 10 0 5 6.6 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL2440927 217751 0 None 15 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040781 217751 0 None 15 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL124061 23372 0 None - 1 Human 7.4 pKi = 7.4 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 591 10 4 9 4.5 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3cccc(O)c3)CC2)c1 10.1016/s0960-894x(01)00761-2
44362784 126132 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 408 7 0 4 5.4 Cc1ccc(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)cc1 10.1016/s0960-894x(99)00019-0
CHEMBL344338 126132 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 408 7 0 4 5.4 Cc1ccc(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)cc1 10.1016/s0960-894x(99)00019-0
44362398 43645 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 470 8 0 4 6.7 CN(C)C1CCN(CCc2c(COc3ccc(-c4ccccc4)cc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145061 43645 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 470 8 0 4 6.7 CN(C)C1CCN(CCc2c(COc3ccc(-c4ccccc4)cc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
46879649 13057 1 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 368 5 2 6 4.9 C[C@@H]1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1081732 13057 1 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 368 5 2 6 4.9 C[C@@H]1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
54580549 68416 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 417 6 2 5 5.3 Cc1cc(NCCNC2CCCC2)n2nc(C)c(-c3c(Cl)cccc3Cl)c2n1 10.1016/j.bmcl.2010.12.116
CHEMBL1771257 68416 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 417 6 2 5 5.3 Cc1cc(NCCNC2CCCC2)n2nc(C)c(-c3c(Cl)cccc3Cl)c2n1 10.1016/j.bmcl.2010.12.116
54584288 68743 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 587 15 7 6 2.7 N=C(N)N(CCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)C(=O)NCCCCN 10.1016/j.bmc.2011.03.045
CHEMBL1774207 68743 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 587 15 7 6 2.7 N=C(N)N(CCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)C(=O)NCCCCN 10.1016/j.bmc.2011.03.045
54587221 69893 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 932 21 6 6 6.7 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774212 69893 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 932 21 6 6 6.7 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789348 69893 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 932 21 6 6 6.7 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
44362861 128131 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 497 7 0 5 5.7 CN(C)C1CCN(CCc2c(COc3ccc(C#N)cc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL358111 128131 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 497 7 0 5 5.7 CN(C)C1CCN(CCc2c(COc3ccc(C#N)cc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
44362989 175413 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 520 7 0 4 5.7 CN(C)C1CCN(CCc2c(COc3ccccc3I)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL436213 175413 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 520 7 0 4 5.7 CN(C)C1CCN(CCc2c(COc3ccccc3I)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
162652708 190439 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 669 15 7 5 3.4 N/C(=N/C(=O)NCCNC(=O)C1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4751668 190439 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 669 15 7 5 3.4 N/C(=N/C(=O)NCCNC(=O)C1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802795 190439 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 669 15 7 5 3.4 N/C(=N/C(=O)NCCNC(=O)C1CCCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44362895 40951 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 462 6 1 4 5.9 CN(C)C1CCN(CCc2c(C(O)c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL142603 40951 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 462 6 1 4 5.9 CN(C)C1CCN(CCc2c(C(O)c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
10624729 113685 0 None - 1 Human 5.4 pKi = 5.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 484 7 3 3 4.4 CC(C)NC(=O)Cc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314662 113685 0 None - 1 Human 5.4 pKi = 5.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 484 7 3 3 4.4 CC(C)NC(=O)Cc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
9911304 68425 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 443 8 2 6 4.6 COc1cc(Cl)c(-c2c(C)nn3c(NCCNCC(F)F)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771266 68425 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 443 8 2 6 4.6 COc1cc(Cl)c(-c2c(C)nn3c(NCCNCC(F)F)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL591971 222582 0 None -2 3 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL None None None None 10.1016/j.bmcl.2009.12.068
CHEMBL4278700 220169 0 None -398 4 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
CHEMBL4292105 220292 0 None -100 4 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL3349022 218183 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL238533 217172 0 None -128 2 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]PYY from NPY1 receptor expressed in human SK-N-MC cellsDisplacement of [125I]PYY from NPY1 receptor expressed in human SK-N-MC cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1016/j.bmcl.2006.10.007
44350924 175767 0 None -58 4 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
91929378 175767 0 None -58 4 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
CHEMBL439122 175767 0 None -58 4 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
CHEMBL4279794 220178 0 None -1584 4 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4279133 220172 0 None -50 4 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CC(=O)O)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4288294 220257 0 None -630 4 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
46879454 12648 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 384 6 2 7 4.5 COc1cccc2sc(NCCc3ccc(NC4=NCCS4)cc3)nc12 10.1016/j.bmcl.2009.09.048
CHEMBL1079441 12648 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 384 6 2 7 4.5 COc1cccc2sc(NCCc3ccc(NC4=NCCS4)cc3)nc12 10.1016/j.bmcl.2009.09.048
CHEMBL127282 215449 0 None -1 2 Human 8.4 pKi = 8.4 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL4290048 220269 0 None -25 4 Human 8.4 pKi = 8.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
127041011 143905 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 688 14 7 8 3.1 N/C(=N/C(=O)NCc1cn(-c2ccc(N)cc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747224 143905 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 688 14 7 8 3.1 N/C(=N/C(=O)NCc1cn(-c2ccc(N)cc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747816 143905 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 688 14 7 8 3.1 N/C(=N/C(=O)NCc1cn(-c2ccc(N)cc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL31913 114518 0 None - 1 Human 8.4 pKi = 8.4 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 590 10 3 8 5.5 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00761-2
54582344 68742 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 587 15 7 5 2.5 NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774206 68742 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 587 15 7 5 2.5 NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
44362660 44414 0 None - 1 Human 8.4 pKi = 8.4 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 522 11 0 5 6.9 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCN2CCCCC2)CC1 10.1016/s0960-894x(99)00082-7
CHEMBL145714 44414 0 None - 1 Human 8.4 pKi = 8.4 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 522 11 0 5 6.9 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCN2CCCCC2)CC1 10.1016/s0960-894x(99)00082-7
44373216 103673 27 None - 1 Human 8.4 pKi = 8.4 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 490 12 1 6 5.7 c1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCNCC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL265752 103673 27 None - 1 Human 8.4 pKi = 8.4 Binding
Ability to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cellsAbility to displace [125I]-peptide YY binding to cloned human Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 490 12 1 6 5.7 c1ccc(OCc2nc3c(OCCCN4CCCCC4)cccc3n2CCCC2CCNCC2)cc1 10.1016/s0960-894x(99)00082-7
CHEMBL3349039 218186 0 None -4 2 Human 8.4 pKi = 8.4 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
44362660 44414 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 522 11 0 5 6.9 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL145714 44414 0 None - 1 Human 8.4 pKi = 8.4 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 522 11 0 5 6.9 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
127041307 143832 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 714 15 6 8 4.4 [N-]=[N+]=Nc1ccc(-n2cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746796 143832 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 714 15 6 8 4.4 [N-]=[N+]=Nc1ccc(-n2cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)cc1 10.1021/acs.jmedchem.5b00925
10076108 185735 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 545 12 5 5 3.2 CCOC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
CHEMBL470496 185735 0 None - 1 Human 8.4 pKi = 8.4 Binding
Displacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cellsDisplacement of [3H]propionyl-pNPY from neuropeptide Y1 receptor in human SK-N-MC cells
ChEMBL 545 12 5 5 3.2 CCOC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm801018u
10524003 22301 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 382 6 0 3 5.4 Cn1c(COc2ccc(Cl)cc2)c(CCN2CCCCC2)c2ccccc21 10.1021/jm970512x
CHEMBL121799 22301 0 None - 1 Human 8.3 pKi = 8.3 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 382 6 0 3 5.4 Cn1c(COc2ccc(Cl)cc2)c(CCN2CCCCC2)c2ccccc21 10.1021/jm970512x
21129772 176203 4 None -2 9 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm9706630
CHEMBL44246 176203 4 None -2 9 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/jm9706630
CHEMBL413426 219845 0 None 20 4 Human 8.3 pKi = 8.3 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](CSSC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)[C@@H](C)CC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)OC 10.1021/jm010031k
CHEMBL4278700 220169 0 None -398 4 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
CHEMBL4292105 220292 0 None -100 4 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
49865804 22919 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 790 23 7 8 5.3 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCCCCC(=O)NCCC(=O)OCc1ccccc1 10.1016/j.bmc.2010.07.028
CHEMBL1223991 22919 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 790 23 7 8 5.3 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCCCCC(=O)NCCC(=O)OCc1ccccc1 10.1016/j.bmc.2010.07.028
CHEMBL2440925 217742 0 None 6 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040675 217742 0 None 6 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCC(=O)NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
44350924 175767 0 None -58 4 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
91929378 175767 0 None -58 4 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
CHEMBL439122 175767 0 None -58 4 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL 2220 73 32 30 -7.4 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/acs.jmedchem.8b01046
CHEMBL4279794 220178 0 None -1584 4 Human 6.4 pKi = 6.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
53359565 143823 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK114 from NPY1R (unknown origin)Displacement of [3H]UR-MK114 from NPY1R (unknown origin)
ChEMBL 860 18 6 12 4.1 CN(Cc1cn(-c2ccc(-n3cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c4ccccc4)c4ccccc4)C(=O)NCc4ccc(O)cc4)nn3)cc2)nn1)c1ccncc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746696 143823 0 None - 1 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK114 from NPY1R (unknown origin)Displacement of [3H]UR-MK114 from NPY1R (unknown origin)
ChEMBL 860 18 6 12 4.1 CN(Cc1cn(-c2ccc(-n3cc(CNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c4ccccc4)c4ccccc4)C(=O)NCc4ccc(O)cc4)nn3)cc2)nn1)c1ccncc1 10.1021/acs.jmedchem.5b00925
155543070 179968 0 None -245 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1761 57 30 22 -3.5 CCC(=O)N[C@@H](CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4522438 179968 0 None -245 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1761 57 30 22 -3.5 CCC(=O)N[C@@H](CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4570354 179968 0 None -245 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1761 57 30 22 -3.5 CCC(=O)N[C@@H](CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
10673317 119197 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 397 7 1 4 5.4 Cc1cccc2nc(COc3ccc(Cl)cc3)n(CCCC3CCCNC3)c12 10.1021/jm9706630
CHEMBL329786 119197 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 397 7 1 4 5.4 Cc1cccc2nc(COc3ccc(Cl)cc3)n(CCCC3CCCNC3)c12 10.1021/jm9706630
44362810 44540 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 476 7 0 4 6.5 COC(c1ccc(Cl)cc1Cl)c1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145808 44540 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 476 7 0 4 6.5 COC(c1ccc(Cl)cc1Cl)c1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL4279133 220172 0 None -50 4 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](CC(=O)O)Cc1ccc(O)cc1)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4288294 220257 0 None -630 4 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(C)[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL124150 23394 0 None - 1 Human 6.4 pKi = 6.4 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 605 11 3 9 4.8 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccc(OC)cc3)CC2)c1 10.1016/s0960-894x(01)00761-2
49865810 22925 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 735 16 10 12 -0.1 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCC(=O)OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O 10.1016/j.bmc.2010.07.028
CHEMBL1223998 22925 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 735 16 10 12 -0.1 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCC(=O)OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O 10.1016/j.bmc.2010.07.028
127041326 143908 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 687 14 5 7 3.8 CN(Cc1cn(-c2ccccc2)nn1)C(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746492 143908 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 687 14 5 7 3.8 CN(Cc1cn(-c2ccccc2)nn1)C(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747819 143908 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 687 14 5 7 3.8 CN(Cc1cn(-c2ccccc2)nn1)C(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
72205667 109345 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 600 17 8 5 2.4 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCN)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2441114 109345 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 600 17 8 5 2.4 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCN)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040753 109345 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 600 17 8 5 2.4 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCN)cc1 10.1016/j.bmc.2013.08.065
10818866 213902 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCC[C@H]4CCCNC4)cccc3n2CCC[C@H]2CCCNC2)cc1 10.1021/jm9706630
CHEMBL92148 213902 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCC[C@H]4CCCNC4)cccc3n2CCC[C@H]2CCCNC2)cc1 10.1021/jm9706630
127031281 145984 0 None -301 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1789 59 29 21 -2.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL3785569 145984 0 None -301 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1789 59 29 21 -2.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL3787712 145984 0 None -301 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1789 59 29 21 -2.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN/C(N)=N/C(=O)NCCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL410007 219574 0 None -1023 2 Human 6.4 pKi = 6.4 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N[C@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N2CCC[C@@H]2C(=O)N[C@H](C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CO)C(=O)N[C@H](C)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
10815247 113659 0 None - 1 Human 5.4 pKi = 5.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 500 7 3 4 5.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(COC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314520 113659 0 None - 1 Human 5.4 pKi = 5.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 500 7 3 4 5.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(COC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL2311081 216283 0 None -58 2 Human 7.4 pKi = 7.4 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
45268459 202953 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 547 7 1 5 5.9 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(N4CCCOC4=O)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL561332 202953 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 547 7 1 5 5.9 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(N4CCCOC4=O)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
54580353 69941 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1004 26 7 8 6.7 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774343 69941 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1004 26 7 8 6.7 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789807 69941 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1004 26 7 8 6.7 CN(C)c1ccc(/C=C/C=C/c2sc3ccccc3[n+]2CCCC(=O)NCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2011.03.045
CHEMBL2440926 217739 0 None 13 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040657 217739 0 None 13 3 Human 7.4 pKi = 7.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)CCCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCC(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
44362777 40897 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 408 7 0 4 5.4 Cc1ccccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL142561 40897 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 408 7 0 4 5.4 Cc1ccccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
44362832 44395 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 486 7 0 4 6.1 Cc1cc(Br)ccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145693 44395 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 486 7 0 4 6.1 Cc1cc(Br)ccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
44362723 127876 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 446 6 0 3 6.4 CN(C)C1CCN(CCc2c(Cc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL357184 127876 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 446 6 0 3 6.4 CN(C)C1CCN(CCc2c(Cc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
136216703 85680 0 None -208 5 Human 5.4 pKi = 5.4 Binding
Binding affinity against Neuropeptide Y receptor type 1 using [125I]PYYBinding affinity against Neuropeptide Y receptor type 1 using [125I]PYY
ChEMBL 482 2 4 7 4.0 N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2 10.1016/s0960-894x(99)00075-x
CHEMBL2112936 85680 0 None -208 5 Human 5.4 pKi = 5.4 Binding
Binding affinity against Neuropeptide Y receptor type 1 using [125I]PYYBinding affinity against Neuropeptide Y receptor type 1 using [125I]PYY
ChEMBL 482 2 4 7 4.0 N[C@H]1CCCC[C@@H]1NC(=O)c1c2c(c3c4c(ncnc14)-c1ccccc1C3=O)N[C@@H]1CCCC[C@H]1N2 10.1016/s0960-894x(99)00075-x
44362610 44366 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 483 10 0 6 5.6 CCOC(=O)CN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc32)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL145663 44366 0 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 483 10 0 6 5.6 CCOC(=O)CN1CCC(CCCn2c(COc3ccc(Cl)cc3)nc3c(C)cccc32)CC1 10.1016/s0960-894x(98)00048-1
25147723 19453 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1295 32 10 14 6.9 N/C(=N/C(=O)CCCn1cc(-c2ccc(-c3cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c4ccccc4)c4ccccc4)C(=O)NCc4ccc(O)cc4)nn3)cc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
25147724 19453 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1295 32 10 14 6.9 N/C(=N/C(=O)CCCn1cc(-c2ccc(-c3cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c4ccccc4)c4ccccc4)C(=O)NCc4ccc(O)cc4)nn3)cc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
91934897 19453 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1295 32 10 14 6.9 N/C(=N/C(=O)CCCn1cc(-c2ccc(-c3cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c4ccccc4)c4ccccc4)C(=O)NCc4ccc(O)cc4)nn3)cc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL1187385 19453 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1295 32 10 14 6.9 N/C(=N/C(=O)CCCn1cc(-c2ccc(-c3cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c4ccccc4)c4ccccc4)C(=O)NCc4ccc(O)cc4)nn3)cc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL501317 19453 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1295 32 10 14 6.9 N/C(=N/C(=O)CCCn1cc(-c2ccc(-c3cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c4ccccc4)c4ccccc4)C(=O)NCc4ccc(O)cc4)nn3)cc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
45268483 201558 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 599 7 1 4 6.3 COc1ccc([C@H](N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)C(F)(F)F)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL538380 201558 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 599 7 1 4 6.3 COc1ccc([C@H](N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)C(F)(F)F)cc1 10.1016/j.bmcl.2009.06.050
10624769 213341 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 485 6 4 3 4.9 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL88742 213341 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 485 6 4 3 4.9 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
10722606 214250 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 510 11 1 6 5.9 Clc1ccc(OCc2nc3c(OCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL94292 214250 0 None - 1 Human 7.4 pKi = 7.4 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 510 11 1 6 5.9 Clc1ccc(OCc2nc3c(OCCN4CCCCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL2440917 217738 0 None 9 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CCCC(=O)NCCN(CCN)CCNC(=O)CCCC(=O)NCCCCNC(=O)NCc2ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c3ccccc3)c3ccccc3)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040656 217738 0 None 9 2 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)CCCC(=O)NCCN(CCN)CCNC(=O)CCCC(=O)NCCCCNC(=O)NCc2ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c3ccccc3)c3ccccc3)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL265426 217429 0 None 77 2 Human 7.4 pKi = 7.4 Binding
Compound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cellsCompound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm950811r
45271861 201885 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 533 6 1 3 5.9 C[C@@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)C(C)(C)C1)c1ccc(F)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL549917 201885 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 533 6 1 3 5.9 C[C@@H](N[C@@H]1CC[C@@H](C(=O)N2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)C(C)(C)C1)c1ccc(F)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL3349022 218183 0 None -3 2 Human 6.4 pKi = 6.4 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
10625004 119846 1 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 493 6 0 5 5.1 Cn1c(COc2ccc(Cl)cc2)c(C(=O)C(=O)N2CCC(N3CCCCC3)CC2)c2ccccc21 10.1021/jm970512x
CHEMBL331202 119846 1 None - 1 Human 6.4 pKi = 6.4 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 493 6 0 5 5.1 Cn1c(COc2ccc(Cl)cc2)c(C(=O)C(=O)N2CCC(N3CCCCC3)CC2)c2ccccc21 10.1021/jm970512x
CHEMBL2440192 217260 0 None -831 3 Human 6.4 pKi = 6.4 Binding
Displacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometryDisplacement of Cy5-pNPY from human Y1 receptor expressed in HEL cells after 90 to 120 mins by flow cytometry
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](N)Cc1ccc(O)cc1 10.1021/jm4008505
155524657 177768 0 None -794 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1705 55 30 22 -4.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)CCCC[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4456247 177768 0 None -794 4 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1705 55 30 22 -4.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](N)CCCC[C@@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4540843 220772 19 None -467 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysisDisplacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysis
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/acs.jmedchem.1c01574
CHEMBL4540843 220772 19 None -467 3 Human 6.4 pKi = 6.4 Binding
Displacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysisDisplacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysis
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O 10.1021/acs.jmedchem.1c01574
45271838 202156 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 546 7 2 4 5.5 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(N4CCCNC4=O)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL551933 202156 0 None - 1 Human 7.4 pKi = 7.4 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 546 7 2 4 5.5 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(N4CCCNC4=O)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
162655171 190452 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 643 14 7 5 2.9 CC(C)(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4756494 190452 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 643 14 7 5 2.9 CC(C)(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802928 190452 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 643 14 7 5 2.9 CC(C)(C)C(=O)NCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44362773 39583 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 424 8 1 5 4.5 CN(C)C1CCN(CCc2c(COc3ccccc3CO)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL141442 39583 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 424 8 1 5 4.5 CN(C)C1CCN(CCc2c(COc3ccccc3CO)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
44362764 44433 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 472 7 0 4 5.8 CN(C)C1CCN(CCc2c(COc3ccccc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145726 44433 0 None - 1 Human 6.4 pKi = 6.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 472 7 0 4 5.8 CN(C)C1CCN(CCc2c(COc3ccccc3Br)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
10552954 113681 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 3 4 5.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(OC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314637 113681 0 None - 1 Human 6.4 pKi = 6.4 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 3 4 5.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(OC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
44362765 44053 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 474 7 1 5 6.2 CN(C)C1CCN(CCc2c(/C=N/Nc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145392 44053 0 None - 1 Human 5.4 pKi = 5.4 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 474 7 1 5 6.2 CN(C)C1CCN(CCc2c(/C=N/Nc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
46231126 205247 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL 2031 71 25 26 -0.7 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CN1CCN(CC(=O)NCCCCCCCC(=O)O)CCN(CC(=O)NCCCCCCCC(=O)O)CCN(CC(=O)NCCCCCCCC(=O)O)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1016/j.bmcl.2009.12.068
91937010 205247 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL 2031 71 25 26 -0.7 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CN1CCN(CC(=O)NCCCCCCCC(=O)O)CCN(CC(=O)NCCCCCCCC(=O)O)CCN(CC(=O)NCCCCCCCC(=O)O)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1016/j.bmcl.2009.12.068
CHEMBL577447 205247 0 None - 1 Human 5.4 pKi = 5.4 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL 2031 71 25 26 -0.7 CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CN1CCN(CC(=O)NCCCCCCCC(=O)O)CCN(CC(=O)NCCCCCCCC(=O)O)CCN(CC(=O)NCCCCCCCC(=O)O)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1016/j.bmcl.2009.12.068
164616390 192055 0 None -234 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysisDisplacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysis
ChEMBL 1093 27 20 14 -4.5 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.1c01574
CHEMBL4858915 192055 0 None -234 2 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysisDisplacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysis
ChEMBL 1093 27 20 14 -4.5 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.1c01574
CHEMBL438548 220555 0 None -4 2 Human 7.3 pKi = 7.3 Binding
Compound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cellsCompound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CSSC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm950811r
49865800 22916 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 711 25 6 5 8.2 CCCCCCCCCCCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
CHEMBL1223987 22916 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 711 25 6 5 8.2 CCCCCCCCCCCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
1507 9658 0 None -346 7 Human 6.3 pKi = 6.3 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None None 10.1021/jm00055a010
44351001 9658 0 None -346 7 Human 6.3 pKi = 6.3 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None None 10.1021/jm00055a010
91929182 9658 0 None -346 7 Human 6.3 pKi = 6.3 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None None 10.1021/jm00055a010
CHEMBL265849 9658 0 None -346 7 Human 6.3 pKi = 6.3 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None None 10.1021/jm00055a010
46879876 12843 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 444 6 2 6 6.6 c1ccc([C@H]2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL1080655 12843 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 444 6 2 6 6.6 c1ccc([C@H]2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
45273649 202576 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 531 7 1 4 5.2 COc1ccc(CN[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL557932 202576 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 531 7 1 4 5.2 COc1ccc(CN[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
10601025 119130 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 487 6 4 4 4.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)COc3ccccc32)c1 10.1021/jm990044m
CHEMBL329425 119130 0 None - 1 Human 6.3 pKi = 6.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 487 6 4 4 4.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)COc3ccccc32)c1 10.1021/jm990044m
9820766 172025 41 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 371 4 1 6 3.7 CC(C)c1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+](=O)[O-] 10.1016/0960-894X(96)00319-8
CHEMBL422942 172025 41 None - 1 Human 7.3 pKi = 7.3 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 371 4 1 6 3.7 CC(C)c1ccccc1S(=O)(=O)c1cc(N)c2ncccc2c1[N+](=O)[O-] 10.1016/0960-894X(96)00319-8
45273630 202481 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 504 8 2 4 6.3 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)C3CCC(NC(C)=O)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL556915 202481 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 504 8 2 4 6.3 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)C3CCC(NC(C)=O)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL2440914 217748 0 None 8 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040731 217748 0 None 8 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
46879690 12887 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 396 7 2 6 5.6 CCCC1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1080826 12887 0 None - 1 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 396 7 2 6 5.6 CCCC1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
21336495 108801 0 None -1737 2 Human 4.3 pKi = 4.3 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 468 9 2 6 4.0 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCc2ccnc3ccccc23)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL301747 108801 0 None -1737 2 Human 4.3 pKi = 4.3 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 468 9 2 6 4.0 O=[N+]([O-])c1ccccc1S(=O)(=O)NC[C@H]1CC[C@H](CNCc2ccnc3ccccc23)CC1 10.1016/s0960-894x(02)00287-1
CHEMBL3349022 218183 0 None -3 2 Human 7.3 pKi = 7.3 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL429071 220279 0 None 81 2 Human 7.3 pKi = 7.3 Binding
Compound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cellsCompound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm950811r
44588507 19235 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 686 16 5 7 4.3 N/C(=N/C(=O)CCCn1cc(-c2ccccc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL1186145 19235 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 686 16 5 7 4.3 N/C(=N/C(=O)CCCn1cc(-c2ccccc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL451670 19235 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 686 16 5 7 4.3 N/C(=N/C(=O)CCCn1cc(-c2ccccc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
45269305 202929 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 518 8 1 4 6.7 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)C3CCC(c4ccccc4)(N(C)C(C)=O)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL561193 202929 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 518 8 1 4 6.7 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)C3CCC(c4ccccc4)(N(C)C(C)=O)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL386823 219174 10 None 1 3 Human 8.3 pKi = 8.3 Binding
Affinity for cloned Y1 receptor using [125I]PYY as radioligandAffinity for cloned Y1 receptor using [125I]PYY as radioligand
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)CC 10.1021/jm010031k
54583518 68421 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 477 7 2 7 4.9 COc1cc(Cl)c(-c2c(C)nn3c(NCC(C)NC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771262 68421 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 477 7 2 7 4.9 COc1cc(Cl)c(-c2c(C)nn3c(NCC(C)NC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
9956814 68423 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 479 7 2 6 5.6 COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCCCC4F)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771264 68423 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 479 7 2 6 5.6 COc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCCCC4F)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL591971 222582 0 None -2 3 Human 8.3 pKi = 8.3 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL None None None None 10.1016/j.bmcl.2009.12.068
CHEMBL5288617 201214 0 None - 1 Human 8.3 pKi = 8.3 Binding
Displacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assayDisplacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assay
ChEMBL 600 10 3 9 4.0 COC(=O)C1=CNC(C)=C(C(=O)OC)C1c1cccc(N/C(=N/C#N)NCCCN2CCC(c3cccc(OC)c3)CC2)c1 10.1039/D1MD00058F
1485 7418 31 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cellsDisplacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2011.03.045
3474 7418 31 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cellsDisplacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2011.03.045
5311023 7418 31 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cellsDisplacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2011.03.045
CHEMBL332347 7418 31 None 1 4 Human 8.3 pKi = 8.3 Binding
Displacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cellsDisplacement of radiolabeled NPY from human Y1R expressed in human SK-N-MC cells
ChEMBL 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 10.1016/j.bmc.2011.03.045
9807379 213398 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 542 6 4 5 5.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ncsc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL89078 213398 0 None - 1 Human 8.3 pKi = 8.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 542 6 4 5 5.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ncsc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL437656 220508 0 None -3 2 Human 8.3 pKi = 8.3 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H]1CSSC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N)Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@H](C)CC 10.1021/jm00055a010
CHEMBL3349022 218183 0 None -3 2 Human 8.3 pKi = 8.3 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL3349022 218183 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
21188533 175025 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 536 12 0 5 7.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL433734 175025 0 None - 1 Human 8.2 pKi = 8.2 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 536 12 0 5 7.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL3349022 218183 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL2440182 217252 0 None 12 2 Human 7.3 pKi = 7.3 Binding
Binding affinity to Y1 receptor (unknown origin)Binding affinity to Y1 receptor (unknown origin)
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]1[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]2[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(N)=O)[C@H]2C(=O)OC)[C@H]1C(=O)OC 10.1021/jm4008505
CHEMBL4276961 220147 0 None -5011 4 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
11560009 12785 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 382 5 2 6 5.2 CC1CCSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1080291 12785 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 382 5 2 6 5.2 CC1CCSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
54581331 69919 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 848 21 5 5 7.5 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774216 69919 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 848 21 5 5 7.5 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789555 69919 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 848 21 5 5 7.5 Cc1cc(/C=C/C=C/c2ccc(N(C)C)cc2)cc(C)[n+]1CCCCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL2440928 217740 0 None 7 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)CCCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040658 217740 0 None 7 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human MCF7 cells
ChEMBL None None None NCCN(CCNC(=O)CCCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCC(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL4276961 220147 0 None -5011 4 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O 10.1021/acs.jmedchem.8b01046
CHEMBL4280392 220185 0 None -389 4 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4281010 220192 0 None -251 4 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)[C@@H](C)O)[C@@H](C)CC)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/acs.jmedchem.8b01046
CHEMBL4282616 220211 0 None -100 4 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4291016 220284 0 None -50 4 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4280392 220185 0 None -389 4 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4281010 220192 0 None -251 4 Human 6.3 pKi = 6.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CCCCCNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)CCC(=O)NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O)[C@@H](C)O)[C@@H](C)CC)NC(=O)[C@H](CC(N)=O)NC1=O 10.1021/acs.jmedchem.8b01046
CHEMBL4282616 220211 0 None -100 4 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N(CCC(N)=O)CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4291016 220284 0 None -50 4 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL124151 23395 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 589 10 3 8 5.1 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccc(C)cc3)CC2)c1 10.1016/s0960-894x(01)00761-2
49865813 22929 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 628 17 9 6 2.8 N=C(N)NCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
CHEMBL1224001 22929 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 628 17 9 6 2.8 N=C(N)NCCCCCC(=O)NC(=N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2010.07.028
21188533 175025 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 536 12 0 5 7.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL433734 175025 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 536 12 0 5 7.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCCN2CCCCC2)CC1 10.1016/s0960-894x(98)00048-1
21188571 176196 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 411 7 0 4 5.7 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(C)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL442412 176196 0 None - 1 Human 7.3 pKi = 7.3 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 411 7 0 4 5.7 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(C)CC1 10.1016/s0960-894x(98)00048-1
162654570 190448 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 655 15 7 5 3.0 N/C(=N/C(=O)NCCNC(=O)C1CCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4755079 190448 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 655 15 7 5 3.0 N/C(=N/C(=O)NCCNC(=O)C1CCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4802896 190448 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 655 15 7 5 3.0 N/C(=N/C(=O)NCCNC(=O)C1CCCC1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
46879610 12638 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 446 6 2 8 4.3 CS(=O)(=O)c1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1079388 12638 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 446 6 2 8 4.3 CS(=O)(=O)c1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL337939 123599 0 None - 1 Human 6.3 pKi = 6.3 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 484 8 3 7 4.1 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCCCC2)c1 10.1016/s0960-894x(01)00761-2
46879522 12696 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 399 6 2 8 4.4 O=[N+]([O-])c1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1079729 12696 0 None - 1 Human 5.3 pKi = 5.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 399 6 2 8 4.4 O=[N+]([O-])c1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
11654472 12786 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 410 6 2 6 5.9 CC(C)C1CCSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1080292 12786 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 410 6 2 6 5.9 CC(C)C1CCSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL2440913 217747 0 None 3 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)c1ccc(C(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040730 217747 0 None 3 3 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None NCCN(CCNC(=O)c1ccc(C(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
10839529 170587 0 None - 1 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 399 7 2 5 4.8 Oc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCCNC1 10.1021/jm9706630
CHEMBL420613 170587 0 None - 1 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 399 7 2 5 4.8 Oc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCCNC1 10.1021/jm9706630
46879781 12844 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 444 6 2 6 6.6 c1ccc(C2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL1080660 12844 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 444 6 2 6 6.6 c1ccc(C2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
11670084 13049 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 474 7 2 7 6.6 COc1ccc(C2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
CHEMBL1081711 13049 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 474 7 2 7 6.6 COc1ccc(C2CCSC(Nc3ccc(CCNc4nc5ccccc5s4)cc3)=N2)cc1 10.1016/j.bmcl.2009.09.048
10601682 170430 0 None - 1 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 506 7 3 4 4.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NS(=O)(=O)c3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL420426 170430 0 None - 1 Human 5.3 pKi = 5.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 506 7 3 4 4.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NS(=O)(=O)c3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
9806472 168770 0 None -257 2 Human 5.3 pKi = 5.3 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 476 8 2 3 5.3 O=S(=O)(NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00287-1
CHEMBL415926 168770 0 None -257 2 Human 5.3 pKi = 5.3 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 476 8 2 3 5.3 O=S(=O)(NC[C@H]1CC[C@H](CNCC2CCc3ccccc3C2)CC1)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00287-1
10671331 23237 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 451 6 0 4 5.9 Cn1c(COc2ccc(Cl)cc2)c(CN2CCC(N3CCCCC3)CC2)c2ccccc21 10.1021/jm970512x
CHEMBL123413 23237 0 None - 1 Human 6.3 pKi = 6.3 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 451 6 0 4 5.9 Cn1c(COc2ccc(Cl)cc2)c(CN2CCC(N3CCCCC3)CC2)c2ccccc21 10.1021/jm970512x
54586222 69895 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1743 49 14 14 8.2 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCNC(=O)CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCNC(=O)CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
91932454 69895 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1743 49 14 14 8.2 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCNC(=O)CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCNC(=O)CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774347 69895 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1743 49 14 14 8.2 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCNC(=O)CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCNC(=O)CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789351 69895 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1743 49 14 14 8.2 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCNC(=O)CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCNC(=O)CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
10816198 112711 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 536 6 4 4 5.4 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ncccc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL312841 112711 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 536 6 4 4 5.4 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ncccc4c3)CCc3ccccc32)c1 10.1021/jm990044m
10625178 113730 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 499 6 4 3 5.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314961 113730 0 None - 1 Human 7.3 pKi = 7.3 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 499 6 4 3 5.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCCc3ccccc32)c1 10.1021/jm990044m
162670721 190531 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 663 15 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4792205 190531 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 663 15 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
CHEMBL4803781 190531 0 None - 1 Human 7.3 pKi = 7.3 Binding
Displacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK299 from Y1 receptor in human SK-N-MC cells by radioligand binding assay
ChEMBL 663 15 7 5 3.1 N/C(=N/C(=O)NCCNC(=O)c1ccccc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1039/c9md00538b
44363018 128752 0 None - 1 Human 5.3 pKi = 5.3 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 460 6 0 4 6.0 CN(C)C1CCN(CCc2c(C(=O)c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL359174 128752 0 None - 1 Human 5.3 pKi = 5.3 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 460 6 0 4 6.0 CN(C)C1CCN(CCc2c(C(=O)c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
21188733 126217 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 515 11 0 4 7.7 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCc2ccccc2)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL344971 126217 0 None - 1 Human 7.2 pKi = 7.2 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 515 11 0 4 7.7 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCc2ccccc2)CC1 10.1016/s0960-894x(98)00048-1
19426762 200221 0 None - 1 Human 7.2 pKi = 7.2 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 347 3 1 6 2.7 Nc1cc(S(=O)(=O)c2ccccc2F)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
CHEMBL52643 200221 0 None - 1 Human 7.2 pKi = 7.2 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 347 3 1 6 2.7 Nc1cc(S(=O)(=O)c2ccccc2F)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
44588503 19479 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1439 46 10 19 5.3 N/C(=N/C(=O)CCCn1cc(COCCOCCOCCOCCOCc2cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
49797584 19479 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1439 46 10 19 5.3 N/C(=N/C(=O)CCCn1cc(COCCOCCOCCOCCOCc2cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL1187587 19479 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1439 46 10 19 5.3 N/C(=N/C(=O)CCCn1cc(COCCOCCOCCOCCOCc2cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL510439 19479 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1439 46 10 19 5.3 N/C(=N/C(=O)CCCn1cc(COCCOCCOCCOCCOCc2cn(CCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c3ccccc3)c3ccccc3)C(=O)NCc3ccc(O)cc3)nn2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
44362628 44387 0 None - 1 Human 5.2 pKi = 5.2 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 538 8 0 4 7.9 CN(C)C1CCN(CCc2c(C(Oc3ccc(Cl)cc3Cl)c3ccccc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145686 44387 0 None - 1 Human 5.2 pKi = 5.2 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 538 8 0 4 7.9 CN(C)C1CCN(CCc2c(C(Oc3ccc(Cl)cc3Cl)c3ccccc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
49865803 22918 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 949 25 8 10 4.2 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)COCCOCCOCC(=O)NCCNC(=O)C1=C2C=Cc3cccc4c3C2C(=CC4)C=C1 10.1016/j.bmc.2010.07.028
CHEMBL1223990 22918 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 949 25 8 10 4.2 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)COCCOCCOCC(=O)NCCNC(=O)C1=C2C=Cc3cccc4c3C2C(=CC4)C=C1 10.1016/j.bmc.2010.07.028
46879523 12697 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 432 6 2 8 3.9 CS(=O)(=O)c1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1079730 12697 0 None - 1 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 432 6 2 8 3.9 CS(=O)(=O)c1ccc2nc(NCCc3ccc(NC4=NCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
15383698 195903 0 None - 1 Human 6.2 pKi = 6.2 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 343 3 1 6 2.9 Cc1ccc(S(=O)(=O)c2cc(N)c3ncccc3c2[N+](=O)[O-])cc1 10.1016/0960-894X(96)00319-8
CHEMBL51048 195903 0 None - 1 Human 6.2 pKi = 6.2 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 343 3 1 6 2.9 Cc1ccc(S(=O)(=O)c2cc(N)c3ncccc3c2[N+](=O)[O-])cc1 10.1016/0960-894X(96)00319-8
10747659 119384 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCC[C@@H]4CCCNC4)cccc3n2CCC[C@@H]2CCCNC2)cc1 10.1021/jm9706630
CHEMBL330223 119384 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 524 12 2 6 6.2 Clc1ccc(OCc2nc3c(OCCC[C@@H]4CCCNC4)cccc3n2CCC[C@@H]2CCCNC2)cc1 10.1021/jm9706630
44588505 19229 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1133 32 10 11 4.1 N/C(=N/C(=O)COCCOCCOCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL1186104 19229 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1133 32 10 11 4.1 N/C(=N/C(=O)COCCOCCOCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL450031 19229 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cellsDisplacement of NG-([2,3-3H]propionyl)-BIBP-3226 from NPY Y1 receptor in human SK-N-MC cells
ChEMBL 1133 32 10 11 4.1 N/C(=N/C(=O)COCCOCCOCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2008.09.033
CHEMBL3349022 218183 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL3349022 218183 0 None -3 2 Human 8.2 pKi = 8.2 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
49865809 22924 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 639 16 7 9 2.3 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCn1cc(CN)nn1 10.1016/j.bmc.2010.07.028
CHEMBL1223997 22924 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 639 16 7 9 2.3 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCn1cc(CN)nn1 10.1016/j.bmc.2010.07.028
127041012 143906 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 673 14 6 7 3.5 N/C(=N/C(=O)NCc1cn(-c2ccccc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3746793 143906 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 673 14 6 7 3.5 N/C(=N/C(=O)NCc1cn(-c2ccccc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL3747817 143906 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assayDisplacement of [3H]UR-MK114 from NPY1R in human SK-N-MC cells by radioligand binding assay
ChEMBL 673 14 6 7 3.5 N/C(=N/C(=O)NCc1cn(-c2ccccc2)nn1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1021/acs.jmedchem.5b00925
CHEMBL429159 220286 0 None -100 2 Human 7.2 pKi = 7.2 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@H](N)Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)NCC(=O)N[C@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@H](C)CC 10.1021/jm00055a010
54584307 69892 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1601 43 12 12 9.2 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
91932452 69892 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1601 43 12 12 9.2 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774345 69892 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1601 43 12 12 9.2 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789347 69892 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1601 43 12 12 9.2 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCN(CCNC(=O)CCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)CCNC(=O)CCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
10554910 112930 0 None - 1 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 561 7 4 3 6.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(-c4ccccc4)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL313612 112930 0 None - 1 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 561 7 4 3 6.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(-c4ccccc4)cc3)CCc3ccccc32)c1 10.1021/jm990044m
46879563 12951 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 382 5 2 6 5.2 Cc1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
CHEMBL1081181 12951 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 382 5 2 6 5.2 Cc1ccc2nc(NCCc3ccc(NC4=NCCCS4)cc3)sc2c1 10.1016/j.bmcl.2009.09.048
11669044 12789 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 424 7 2 6 6.3 CC(C)CC1CCSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1080300 12789 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 424 7 2 6 6.3 CC(C)CC1CCSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL592100 222583 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCNC(=O)CN1CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1016/j.bmcl.2009.12.068
CHEMBL2440923 217268 0 None 31 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None N/C(=N/C(=O)CCCCCCC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL4277590 220152 0 None -1258 4 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4277676 220154 0 None -794 4 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4277590 220152 0 None -1258 4 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4277676 220154 0 None -794 4 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)CC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4287058 220246 0 None -2511 4 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4290891 220283 0 None -199 4 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4287058 220246 0 None -2511 4 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)CC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4290891 220283 0 None -199 4 Human 5.2 pKi = 5.2 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL2440916 217741 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None CCC(=O)NCCN(CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040674 217741 0 None 4 2 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL None None None CCC(=O)NCCN(CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1)CCNC(=O)c1ccc(C(=O)NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c2ccccc2)c2ccccc2)C(=O)NCc2ccc(O)cc2)cc1 10.1016/j.bmc.2013.08.065
10554549 212832 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 544 8 6 5 3.8 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(/N=C(\NCCO)Nc3ccc(O)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL85297 212832 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 544 8 6 5 3.8 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(/N=C(\NCCO)Nc3ccc(O)cc3)CCc3ccccc32)c1 10.1021/jm990044m
44362878 128757 0 None - 1 Human 5.2 pKi = 5.2 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 432 5 0 3 6.4 CN(C)C1CCN(CCc2c(-c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL359192 128757 0 None - 1 Human 5.2 pKi = 5.2 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 432 5 0 3 6.4 CN(C)C1CCN(CCc2c(-c3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
10649849 174774 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 528 7 4 4 5.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(N(C)C)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL431990 174774 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 528 7 4 4 5.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(N(C)C)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL124275 23460 0 None - 1 Human 7.2 pKi = 7.2 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 575 10 3 8 4.8 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3)CC2)c1 10.1016/s0960-894x(01)00761-2
44362460 40831 0 None - 1 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 515 9 1 5 5.5 CNCc1cc(Br)ccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL142495 40831 0 None - 1 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 515 9 1 5 5.5 CNCc1cc(Br)ccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL3349022 218183 0 None -3 2 Human 6.2 pKi = 6.2 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL340209 124587 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 643 10 3 8 6.1 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccc(Cl)c(Cl)c3)CC2)c1 10.1016/s0960-894x(01)00761-2
CHEMBL124953 23644 0 None - 1 Human 6.2 pKi = 6.2 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 558 9 3 8 4.8 CO/C(O)=C1\C(C)=NC(C)=C(C#N)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00761-2
46879691 12888 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 410 8 2 6 6.0 CCCCC1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1080827 12888 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 410 8 2 6 6.0 CCCCC1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
44362815 125990 0 None - 1 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 476 7 0 4 6.9 CC(CN1CCC(N(C)C)CC1)c1c(COc2ccc(Cl)cc2Cl)sc2ccccc12 10.1016/s0960-894x(99)00019-0
CHEMBL343313 125990 0 None - 1 Human 6.2 pKi = 6.2 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 476 7 0 4 6.9 CC(CN1CCC(N(C)C)CC1)c1c(COc2ccc(Cl)cc2Cl)sc2ccccc12 10.1016/s0960-894x(99)00019-0
10578417 174775 0 None - 1 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 542 6 4 5 5.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3nc4ccccc4s3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL431994 174775 0 None - 1 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 542 6 4 5 5.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3nc4ccccc4s3)CCc3ccccc32)c1 10.1021/jm990044m
10838640 212754 0 None - 1 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 3 4 5.3 CC(C)OC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL84632 212754 0 None - 1 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 3 4 5.3 CC(C)OC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
9932616 68417 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 433 6 2 6 4.5 Cc1cc(NCCNC2CCOCC2)n2nc(C)c(-c3c(Cl)cccc3Cl)c2n1 10.1016/j.bmcl.2010.12.116
CHEMBL1771258 68417 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 433 6 2 6 4.5 Cc1cc(NCCNC2CCOCC2)n2nc(C)c(-c3c(Cl)cccc3Cl)c2n1 10.1016/j.bmcl.2010.12.116
CHEMBL592121 222585 0 None - 1 Human 8.2 pKi = 8.2 Binding
Displacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 minsDisplacement of [125I]NPY from human neuropeptide Y1 receptor expressed in human MCF7 cells after 40 mins
ChEMBL None None None None 10.1016/j.bmcl.2009.12.068
10747569 213788 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 510 11 2 6 5.8 Clc1ccc(OCc2nc3c(OCCC4CCNCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL91462 213788 0 None - 1 Human 8.2 pKi = 8.2 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 510 11 2 6 5.8 Clc1ccc(OCc2nc3c(OCCC4CCNCC4)cccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
45269316 203058 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 5.7 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL561999 203058 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 5.7 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(C(=O)N4CCCC4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
72205287 109320 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 647 19 7 7 1.7 NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440930 109320 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 647 19 7 7 1.7 NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040665 109320 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 647 19 7 7 1.7 NCCOCCOCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
9806521 103321 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 514 6 5 4 4.5 C/N=C(/Nc1ccc(O)cc1)NC1CCc2ccccc2N(Cc2cccc(NC(=O)NC(C)C)c2)C1=O 10.1021/jm990044m
CHEMBL262904 103321 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 514 6 5 4 4.5 C/N=C(/Nc1ccc(O)cc1)NC1CCc2ccccc2N(Cc2cccc(NC(=O)NC(C)C)c2)C1=O 10.1021/jm990044m
45270973 201875 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 524 7 1 3 7.1 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL549851 201875 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 524 7 1 3 7.1 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4ccccc4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL2371908 216927 0 None -151 3 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O 10.1021/jm050907d
10601584 113947 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 503 6 4 3 5.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3F)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL316366 113947 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 503 6 4 3 5.0 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3F)CCc3ccccc32)c1 10.1021/jm990044m
10768834 113684 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 541 6 4 4 6.1 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ccsc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314656 113684 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 541 6 4 4 6.1 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ccsc4c3)CCc3ccccc32)c1 10.1021/jm990044m
10768322 202580 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 521 6 4 3 5.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(F)cc3F)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL557948 202580 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 521 6 4 3 5.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(F)cc3F)CCc3ccccc32)c1 10.1021/jm990044m
10649770 213045 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 525 6 4 4 5.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ccoc4c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL86898 213045 0 None - 1 Human 8.1 pKi = 8.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 525 6 4 4 5.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4ccoc4c3)CCc3ccccc32)c1 10.1021/jm990044m
10601376 213838 0 None - 1 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 383 7 1 4 5.0 Clc1ccc(OCc2nc3ccccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
CHEMBL91738 213838 0 None - 1 Human 6.2 pKi = 6.2 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 383 7 1 4 5.0 Clc1ccc(OCc2nc3ccccc3n2CCCC2CCCNC2)cc1 10.1021/jm9706630
10741628 213455 0 None - 1 Human 5.2 pKi = 5.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 437 6 4 3 3.9 CC(C)NC(=O)Nc1cccc(CN2CCCCC(NC(=O)Nc3ccccc3)C2=O)c1 10.1021/jm990044m
CHEMBL89460 213455 0 None - 1 Human 5.2 pKi = 5.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 437 6 4 3 3.9 CC(C)NC(=O)Nc1cccc(CN2CCCCC(NC(=O)Nc3ccccc3)C2=O)c1 10.1021/jm990044m
10786219 113935 0 None - 1 Human 5.2 pKi = 5.2 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 383 7 0 4 5.1 Clc1ccc(OCc2nc3ccccc3n2CCCN2CCCCC2)cc1 10.1021/jm9706630
CHEMBL316291 113935 0 None - 1 Human 5.2 pKi = 5.2 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 383 7 0 4 5.1 Clc1ccc(OCc2nc3ccccc3n2CCCN2CCCCC2)cc1 10.1021/jm9706630
73355615 109344 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 903 31 10 10 0.6 NCCCOCCOCCOCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440910 109344 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 903 31 10 10 0.6 NCCCOCCOCCOCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040752 109344 0 None - 1 Human 7.2 pKi = 7.2 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 903 31 10 10 0.6 NCCCOCCOCCOCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
10744516 213202 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 519 6 4 3 5.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL87896 213202 0 None - 1 Human 7.2 pKi = 7.2 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 519 6 4 3 5.5 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(Cl)cc3)CCc3ccccc32)c1 10.1021/jm990044m
46879692 12271 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 410 7 2 6 5.9 CC(C)C[C@@H]1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1076276 12271 0 None - 1 Human 6.2 pKi = 6.2 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 410 7 2 6 5.9 CC(C)C[C@@H]1CSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
44362831 125899 0 None - 1 Human 6.1 pKi = 6.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 540 7 0 4 6.8 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3C(F)(F)F)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL342751 125899 0 None - 1 Human 6.1 pKi = 6.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 540 7 0 4 6.8 CN(C)C1CCN(CCc2c(COc3ccc(Br)cc3C(F)(F)F)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
127029975 145994 0 None -144 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1675 55 28 20 -1.9 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL3785576 145994 0 None -144 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1675 55 28 20 -1.9 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL3787766 145994 0 None -144 4 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1675 55 28 20 -1.9 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCCCCCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
49865811 22926 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 700 21 8 7 3.7 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCCCCC(=O)NCCC(=O)O 10.1016/j.bmc.2010.07.028
CHEMBL1223999 22926 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from NPY1 receptor in human SK-N-MC cells
ChEMBL 700 21 8 7 3.7 N=C(NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1)NC(=O)CCCCCCC(=O)NCCC(=O)O 10.1016/j.bmc.2010.07.028
72205853 109322 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 713 21 9 6 2.1 CCC(=O)NCC(=O)NCCCCNC(=O)NCc1ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440920 109322 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 713 21 9 6 2.1 CCC(=O)NCC(=O)NCCCCNC(=O)NCc1ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040669 109322 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 713 21 9 6 2.1 CCC(=O)NCC(=O)NCCCCNC(=O)NCc1ccc(CNC(=O)[C@@H](CCCNC(=N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1 10.1016/j.bmc.2013.08.065
10599930 118323 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 457 5 4 3 4.1 CNC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL328000 118323 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 457 5 4 3 4.1 CNC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
44294942 193306 0 None -58 2 Human 5.1 pKi = 5.1 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 446 11 2 3 5.6 O=S(=O)(NCCCCCCNCc1ccc2ccccc2c1)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00287-1
CHEMBL48777 193306 0 None -58 2 Human 5.1 pKi = 5.1 Binding
Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1Tested for radioligand binding affinity against membranes from COS-7 cells transiently transfected with Neuropeptide Y receptor type 1
ChEMBL 446 11 2 3 5.6 O=S(=O)(NCCCCCCNCc1ccc2ccccc2c1)c1ccc2ccccc2c1 10.1016/s0960-894x(02)00287-1
44362412 44204 0 None - 1 Human 6.1 pKi = 6.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 462 7 0 4 6.1 CN(C)C1CCN(CCc2c(COc3ccc(C(F)(F)F)cc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145510 44204 0 None - 1 Human 6.1 pKi = 6.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 462 7 0 4 6.1 CN(C)C1CCN(CCc2c(COc3ccc(C(F)(F)F)cc3)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
10720174 213243 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 499 7 4 3 5.1 CC(C)CNC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL88141 213243 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 499 7 4 3 5.1 CC(C)CNC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL3104112 217832 0 None -83 3 Human 6.1 pKi = 6.1 Binding
Binding affinity to NPYY1 receptor (unknown origin)Binding affinity to NPYY1 receptor (unknown origin)
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)c1cccnc1SCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)C(C)C 10.1016/j.bmcl.2013.11.061
164616390 192055 0 None -234 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysisDisplacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysis
ChEMBL 1093 27 20 14 -4.5 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.1c01574
CHEMBL4858915 192055 0 None -234 2 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysisDisplacement of [3H]UR-MK299 from human neuropeptide Y Y1 receptor in human SK-N-MC cells measured after 90 mins by scintillation counting analysis
ChEMBL 1093 27 20 14 -4.5 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.1c01574
73352596 109329 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 845 27 10 9 0.2 NCCOCCOCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440908 109329 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 845 27 10 9 0.2 NCCOCCOCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040698 109329 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 845 27 10 9 0.2 NCCOCCOCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
44362863 43828 0 None - 1 Human 7.1 pKi = 7.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 486 7 0 4 6.1 Cc1ccc(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)c(Br)c1 10.1016/s0960-894x(99)00019-0
CHEMBL145205 43828 0 None - 1 Human 7.1 pKi = 7.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 486 7 0 4 6.1 Cc1ccc(OCc2sc3ccccc3c2CCN2CCC(N(C)C)CC2)c(Br)c1 10.1016/s0960-894x(99)00019-0
10531064 113790 0 None - 1 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 568 6 4 5 4.1 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)C(=O)N(C)C4=O)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL315378 113790 0 None - 1 Human 6.1 pKi = 6.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 568 6 4 5 4.1 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc4c(c3)C(=O)N(C)C4=O)CCc3ccccc32)c1 10.1021/jm990044m
10719643 119590 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 369 6 1 4 4.8 Clc1ccc(OCc2nc3ccccc3n2CCC2CCCCN2)cc1 10.1021/jm9706630
CHEMBL330703 119590 0 None - 1 Human 5.1 pKi = 5.1 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 369 6 1 4 4.8 Clc1ccc(OCc2nc3ccccc3n2CCC2CCCCN2)cc1 10.1021/jm9706630
45270156 201814 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 5.7 COc1ccccc1[C@@H](C)N[C@@H]1CC[C@@H](C(=O)N2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)C(C)(C)C1 10.1016/j.bmcl.2009.06.050
CHEMBL549377 201814 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 545 7 1 4 5.7 COc1ccccc1[C@@H](C)N[C@@H]1CC[C@@H](C(=O)N2CCC(C(=O)N3CCCC3)(c3ccccc3)CC2)C(C)(C)C1 10.1016/j.bmcl.2009.06.050
44362704 43761 0 None - 1 Human 5.1 pKi = 5.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 456 4 0 3 6.2 CN(C)C1CCN(CCc2c(C#Cc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL145161 43761 0 None - 1 Human 5.1 pKi = 5.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 456 4 0 3 6.2 CN(C)C1CCN(CCc2c(C#Cc3ccc(Cl)cc3Cl)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL4282168 220208 0 None -2511 4 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccccc1N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
CHEMBL4282168 220208 0 None -2511 4 Human 5.1 pKi = 5.1 Binding
Displacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assayDisplacement of [125I]-PYY(1 to 36 residues) from human Y1R expressed in BHK-21 cell membranes after 2 hrs by scintillation proximity assay
ChEMBL None None None CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccccc1N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C 10.1021/acs.jmedchem.8b01046
9805674 68420 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 491 9 2 7 5.3 CCCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
CHEMBL1771261 68420 0 None - 1 Human 8.1 pKi = 8.1 Binding
Displacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cellsDisplacement of [125I]-PYY from human recombinant NPY Y1 receptor overexpressed in membrane of Sf9 cells
ChEMBL 491 9 2 7 5.3 CCCOc1cc(Cl)c(-c2c(C)nn3c(NCCNC4CCOCC4)cc(C)nc23)c(Cl)c1 10.1016/j.bmcl.2010.12.116
155546907 180414 0 None 19 2 Human 8.1 pKi = 8.1 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2379 58 36 30 -6.0 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL4534028 180414 0 None 19 2 Human 8.1 pKi = 8.1 Binding
Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assayDisplacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by (sCy5)-[Lys2 Arg4]-BVD15 addition and measured after 30 mins by fluorescence based assay
ChEMBL 2379 58 36 30 -6.0 CC[C@H](C)[C@H](N)C(=O)N[C@H]1CCC(=O)NCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)[C@@H](N)[C@@H](C)CC)CCC(=O)NCC[C@@H](C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc2ccc(O)cc2)C(N)=O)NC(=O)[C@@H]2CCCN2C1=O 10.1021/acs.jmedchem.0c00027
CHEMBL2371911 216930 0 None -29 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
10577766 119561 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 515 7 4 4 4.9 COc1ccc(NC(=O)NC2CCc3ccccc3N(Cc3cccc(NC(=O)NC(C)C)c3)C2=O)cc1 10.1021/jm990044m
CHEMBL330574 119561 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 515 7 4 4 4.9 COc1ccc(NC(=O)NC2CCc3ccccc3N(Cc3cccc(NC(=O)NC(C)C)c3)C2=O)cc1 10.1021/jm990044m
10696766 174808 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 501 6 5 4 4.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(O)cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL432188 174808 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 501 6 5 4 4.6 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc(O)cc3)CCc3ccccc32)c1 10.1021/jm990044m
10838641 213026 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 4 4 4.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccncc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL86775 213026 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 486 6 4 4 4.3 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccncc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL271525 104505 0 None - 1 Human 7.1 pKi = 7.1 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 574 10 3 7 5.6 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCC(Cc3ccccc3)CC2)c1 10.1016/s0960-894x(01)00761-2
CHEMBL3349022 218183 0 None -3 2 Human 7.1 pKi = 7.1 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
73349568 109342 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 828 24 11 8 -0.3 NCCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440902 109342 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 828 24 11 8 -0.3 NCCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040743 109342 0 None - 1 Human 7.1 pKi = 7.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 828 24 11 8 -0.3 NCCC(=O)NCCNC(=O)CCC(=O)NCCNC(=O)/N=C(\N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(N)=O)cc1 10.1016/j.bmc.2013.08.065
10554007 175714 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 521 6 4 3 5.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3cc(F)cc(F)c3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL438777 175714 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 521 6 4 3 5.2 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3cc(F)cc(F)c3)CCc3ccccc32)c1 10.1021/jm990044m
44351120 175589 0 None -16 2 Human 7.1 pKi = 7.1 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 89 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
91929372 175589 0 None -16 2 Human 7.1 pKi = 7.1 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 89 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
CHEMBL437671 175589 0 None -16 2 Human 7.1 pKi = 7.1 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL 3255 89 45 45 -10.8 CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H]1CSSC[C@H](NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
21188674 41094 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 482 11 1 5 5.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCC(N)=O)CC1 10.1016/s0960-894x(98)00048-1
CHEMBL142720 41094 0 None - 1 Human 7.1 pKi = 7.1 Binding
Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.Binding affinity at cloned Neuropeptide Y-1 receptor expressed in AV-12 cells is evaluated.
ChEMBL 482 11 1 5 5.3 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCN(CCCC(N)=O)CC1 10.1016/s0960-894x(98)00048-1
10673787 113723 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 530 7 4 5 4.8 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCc3ccccc32)c1 10.1021/jm990044m
CHEMBL314926 113723 0 None - 1 Human 7.1 pKi = 7.1 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 530 7 4 5 4.8 CC(C)NC(=O)Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccc([N+](=O)[O-])cc3)CCc3ccccc32)c1 10.1021/jm990044m
44362839 40581 0 None - 1 Human 4.1 pKi = 4.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 318 5 1 4 3.0 CN(C)C1CCN(CCc2c(CO)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL142292 40581 0 None - 1 Human 4.1 pKi = 4.1 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 318 5 1 4 3.0 CN(C)C1CCN(CCc2c(CO)sc3ccccc23)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL341329 125253 0 None - 1 Human 7.1 pKi = 7.1 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 574 10 3 7 5.9 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCC(c3ccccc3)CC2)c1 10.1016/s0960-894x(01)00761-2
45271828 202037 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 516 7 1 6 5.5 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4nnco4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
CHEMBL551132 202037 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation countingDisplacement of [125I]PYY from human recombinant neuropeptide Y1 receptor expressed in CHO (NFAT-bla) cells by scintillation counting
ChEMBL 516 7 1 6 5.5 COc1ccc([C@@H](C)N[C@@H]2CC[C@@H](C(=O)N3CCC(c4ccccc4)(c4nnco4)CC3)C(C)(C)C2)cc1 10.1016/j.bmcl.2009.06.050
72205669 109343 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 686 20 10 6 1.7 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)NCCN)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440918 109343 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 686 20 10 6 1.7 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)NCCN)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040749 109343 0 None - 1 Human 6.1 pKi = 6.1 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 686 20 10 6 1.7 N=C(N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(CNC(=O)NCCCCNC(=O)NCCN)cc1 10.1016/j.bmc.2013.08.065
19426755 108717 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 363 3 1 6 3.2 Nc1cc(S(=O)(=O)c2cccc(Cl)c2)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
CHEMBL301150 108717 0 None - 1 Human 6.1 pKi = 6.1 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 363 3 1 6 3.2 Nc1cc(S(=O)(=O)c2cccc(Cl)c2)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
CHEMBL3349022 218183 0 None -3 2 Human 8.0 pKi = 8.0 Binding
Affinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cellsAffinity against Neuropeptide Y1 receptor on SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00076a007
CHEMBL420514 170502 0 None - 1 Human 8.0 pKi = 8.0 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 566 9 3 7 5.9 COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(NC(=O)NCCCN2CCC(C3CCCCC3)CC2)c1 10.1016/s0960-894x(01)00761-2
72205291 109339 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 615 17 7 5 3.2 NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2440934 109339 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 615 17 7 5 3.2 NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL3040736 109339 0 None - 1 Human 8.0 pKi = 8 Binding
Displacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cellsDisplacement of [3H]UR-MK114 from human neuropeptide Y receptor type 1 expressed in human SK-N-MC cells
ChEMBL 615 17 7 5 3.2 NCCCCCCNC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2013.08.065
CHEMBL2371911 216930 0 None -29 3 Human 7.1 pKi = 7.1 Binding
Displacement of [125I]NPY from human NPY1 receptor expressed in CHO cellsDisplacement of [125I]NPY from human NPY1 receptor expressed in CHO cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm050907d
10743445 118208 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 483 6 4 3 4.6 O=C(Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1)NC1CC1 10.1021/jm990044m
CHEMBL327410 118208 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cellsIn vitro binding affinity towards Neuropeptide Y receptor type 1 was determined as potency to displace [125I]-peptide YY binding to human neuroblastoma SK-N-MC cells
ChEMBL 483 6 4 3 4.6 O=C(Nc1cccc(CN2C(=O)C(NC(=O)Nc3ccccc3)CCc3ccccc32)c1)NC1CC1 10.1021/jm990044m
11798404 23106 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 465 7 0 4 5.9 Cn1c(COc2ccc(Cl)cc2)c(CCN2CCC(N3CCCCC3)CC2)c2ccccc21 10.1021/jm970512x
CHEMBL122841 23106 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 465 7 0 4 5.9 Cn1c(COc2ccc(Cl)cc2)c(CCN2CCC(N3CCCCC3)CC2)c2ccccc21 10.1021/jm970512x
19426760 108465 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 363 3 1 6 3.2 Nc1cc(S(=O)(=O)c2ccccc2Cl)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
CHEMBL299384 108465 0 None - 1 Human 7.0 pKi = 7.0 Binding
Compound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligandCompound was tested for binding affinity against neuropeptide Y1 (NPY1) receptor from SK-N-MC membranes using [125I]PYY as radioligand
ChEMBL 363 3 1 6 3.2 Nc1cc(S(=O)(=O)c2ccccc2Cl)c([N+](=O)[O-])c2cccnc12 10.1016/0960-894X(96)00319-8
CHEMBL410780 219619 0 None 6 2 Human 7.0 pKi = 7.0 Binding
Compound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cellsCompound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm950811r
85472343 179081 0 None -151 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1705 55 30 22 -4.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
CHEMBL4475071 179081 0 None -151 4 Human 6.0 pKi = 6.0 Binding
Displacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation countingDisplacement of [3H]UR-MK136 from human NPY Y1 receptor expressed in human MCF7 cells by liquid scintillation counting
ChEMBL 1705 55 30 22 -4.0 CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/acs.jmedchem.6b00309
10791009 213628 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 369 6 1 4 4.7 Clc1ccc(OCc2nc3ccccc3n2CCC2CCNCC2)cc1 10.1021/jm9706630
CHEMBL90574 213628 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 369 6 1 4 4.7 Clc1ccc(OCc2nc3ccccc3n2CCC2CCNCC2)cc1 10.1021/jm9706630
CHEMBL441204 220664 0 None 10 2 Human 7.0 pKi = 7.0 Binding
Compound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cellsCompound was tested for the displacement of [125I]-PYY (SK-N-MC) from Neuropeptide Y receptor type 1 in the membranes prepared from cells
ChEMBL None None None CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)CC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O 10.1021/jm950811r
46879824 13090 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 478 6 2 6 7.3 Clc1ccccc1C1CCSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
CHEMBL1081890 13090 0 None - 1 Human 6.0 pKi = 6.0 Binding
Displacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation countingDisplacement of [125I]pig PPY from human NPY1 receptor expressed in CHOK1 cells by scintillation counting
ChEMBL 478 6 2 6 7.3 Clc1ccccc1C1CCSC(Nc2ccc(CCNc3nc4ccccc4s3)cc2)=N1 10.1016/j.bmcl.2009.09.048
54582350 69944 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1056 26 6 8 7.9 Cc1cc(/C=C/C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774219 69944 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1056 26 6 8 7.9 Cc1cc(/C=C/C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789821 69944 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 1056 26 6 8 7.9 Cc1cc(/C=C/C=C2\N(C)c3ccc4ccccc4c3C2(C)C)cc(C)[n+]1CCOCCOCCNC(=O)CCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL127962 25595 0 None - 1 Human 7.0 pKi = 7.0 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 589 10 3 8 5.1 CCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3C)CC2)c1 10.1016/s0960-894x(01)00761-2
CHEMBL427966 220176 0 None -25 2 Human 7.0 pKi = 7.0 Binding
Tested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cellsTested against neuropeptide Y1 receptors using SK-N-MC human neuroblastoma cells
ChEMBL None None None CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H]1CCCCNC(=O)CC[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]2CCCN2C(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)N2CCC[C@@H]2C(=O)N[C@H](C)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC 10.1021/jm00055a010
54586208 69936 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 965 25 5 8 6.5 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCOCCOCCOCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1774213 69936 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 965 25 5 8 6.5 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCOCCOCCOCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
CHEMBL1789790 69936 0 None - 1 Human 7.0 pKi = 7.0 Binding
Displacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cellsDisplacement of [3H]-UR-MK114 from Y1R in human SK-N-MC cells
ChEMBL 965 25 5 8 6.5 Cc1cc(/C=C/c2cc3c4c(c2)CCCN4CCC3)cc(C)[n+]1CCOCCOCCOCCC(=O)/N=C(/N)NCCC[C@@H](NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 10.1016/j.bmc.2011.03.045
10625562 119093 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 397 7 1 4 5.4 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCCNC1 10.1021/jm9706630
CHEMBL329224 119093 0 None - 1 Human 7.0 pKi = 7.0 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 397 7 1 4 5.4 Cc1cccc2c1nc(COc1ccc(Cl)cc1)n2CCCC1CCCNC1 10.1021/jm9706630
10554658 22274 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 548 9 0 5 6.8 Clc1ccc(OCc2c(CN3CCC(N4CCCCC4)CC3)c3ccccc3n2CCN2CCCCC2)cc1 10.1021/jm970512x
CHEMBL121636 22274 0 None - 1 Human 7.0 pKi = 7.0 Binding
Binding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cellsBinding affinity for Neuropeptide Y receptor type 1 expressed in AV-12 cells
ChEMBL 548 9 0 5 6.8 Clc1ccc(OCc2c(CN3CCC(N4CCCCC4)CC3)c3ccccc3n2CCN2CCCCC2)cc1 10.1021/jm970512x
44362999 127724 0 None - 1 Human 6.0 pKi = 6.0 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 434 9 0 4 5.8 C=CCc1ccccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
CHEMBL356118 127724 0 None - 1 Human 6.0 pKi = 6.0 Binding
Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.Ability to displace [125I]pPYY from AV12 cell line stably transfected with cloned human neuropeptide Y receptor type 1.
ChEMBL 434 9 0 4 5.8 C=CCc1ccccc1OCc1sc2ccccc2c1CCN1CCC(N(C)C)CC1 10.1016/s0960-894x(99)00019-0
10601378 213630 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 383 7 1 4 5.0 Clc1ccc(OCc2nc3ccccc3n2CCCC2CCNCC2)cc1 10.1021/jm9706630
CHEMBL90605 213630 0 None - 1 Human 6.0 pKi = 6.0 Binding
In vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YYIn vitro binding affinity towards human neuropeptide Y receptor type 1, determined by measuring its ability to displace [125]peptide YY
ChEMBL 383 7 1 4 5.0 Clc1ccc(OCc2nc3ccccc3n2CCCC2CCNCC2)cc1 10.1021/jm9706630
CHEMBL5288434 201203 0 None - 1 Human 7.0 pKi = 7 Binding
Displacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assayDisplacement of 125I-PYY from human neuropeptide Y Y1 receptor expressed in human SK-N-MC cell membrane assessed as inhibition constant incubated for 1 hrs by competitive binding assay
ChEMBL 573 9 2 11 4.4 COC(=O)C1=CNC(C)=C(C(=O)OC)C1c1cccc(Nc2nnc(CN3CCC(c4cccc(OC)c4)CC3)o2)c1 10.1039/D1MD00058F
CHEMBL339255 123859 0 None - 1 Human 6.0 pKi = 6 Binding
Inhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membraneInhibition of binding of [125I]PYY radioligand to human neuropeptide Y1 receptor in SK-N-MC cell membrane
ChEMBL 633 13 3 9 5.6 CCCCO/C(O)=C1\C(C)=NC(C)=C(C(=O)OC)C1c1cccc(NC(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1 10.1016/s0960-894x(01)00761-2
1485 7418 31 None 1 4 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O None
3474 7418 31 None 1 4 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O None
5311023 7418 31 None 1 4 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O None
CHEMBL332347 7418 31 None 1 4 Human 8.7 pKd = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O None
1504 9583 8 None -11 10 Mouse 8.8 pKd None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7623780
1518 9583 8 None -11 10 Mouse 8.8 pKd None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7623780
1521 9583 8 None -11 10 Mouse 8.8 pKd None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7623780
24868177 9583 8 None -11 10 Mouse 8.8 pKd None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7623780
44288922 9583 8 None -11 10 Mouse 8.8 pKd None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7623780
77068007 9583 8 None -11 10 Mouse 8.8 pKd None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7623780
90479759 9583 8 None -11 10 Mouse 8.8 pKd None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7623780
CHEMBL438945 9583 8 None -11 10 Mouse 8.8 pKd None 8.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 7623780
1504 9583 8 None 1 10 Rat 9.2 pKd None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
1518 9583 8 None 1 10 Rat 9.2 pKd None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
1521 9583 8 None 1 10 Rat 9.2 pKd None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
24868177 9583 8 None 1 10 Rat 9.2 pKd None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
44288922 9583 8 None 1 10 Rat 9.2 pKd None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
77068007 9583 8 None 1 10 Rat 9.2 pKd None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
90479759 9583 8 None 1 10 Rat 9.2 pKd None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
CHEMBL438945 9583 8 None 1 10 Rat 9.2 pKd None 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 1316999
164509830 222834 0 [125I] - Peptide YY -1 8 Guinea pig 10.3 pKi = 10.3 Binding
NoneNone
PDSP KiDatabase 1343 78 1 7 27.5 CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCCC/C=C\C/C=C\C/C=C\C/C=C\CC None
None 222835 0 125I-[Leu31,Pro34]PYY -26 13 Rat 10.1 pKi = 10.1 Binding
NoneNone
PDSP KiDatabase None None None None None
164509830 222834 0 [125I] - Peptide YY -3 8 Rat 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 1343 78 1 7 27.5 CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCCC/C=C\C/C=C\C/C=C\C/C=C\CC None
126455957 222833 0 [125I] - Peptide YY 1 5 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 4307 134 63 59 -16.4 CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC5=CC=C(C=C5)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC6=CNC=N6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)NC(=O)[C@@H]9CCCN9C(=O)[C@H](CC1=CC=C(C=C1)O)N None
164509830 222834 0 125I-PYY -4 8 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 1343 78 1 7 27.5 CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCCC/C=C\C/C=C\C/C=C\C/C=C\CC None
164509830 222834 0 125I-PYY -4 8 Human 9.9 pKi = 9.9 Binding
NoneNone
PDSP KiDatabase 1343 78 1 7 27.5 CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCCC/C=C\C/C=C\C/C=C\C/C=C\CC None
None 222838 0 125I-PYY 15 2 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase None None None None None
126455957 222833 0 125I-PYY 1 5 Human 9.8 pKi = 9.8 Binding
NoneNone
PDSP KiDatabase 4307 134 63 59 -16.4 CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC5=CC=C(C=C5)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC6=CNC=N6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)NC(=O)[C@@H]9CCCN9C(=O)[C@H](CC1=CC=C(C=C1)O)N None
126455957 222833 0 [125I] - Peptide YY -1 5 Rhesus macaque 9.7 pKi = 9.7 Binding
NoneNone
PDSP KiDatabase 4307 134 63 59 -16.4 CC[C@H](C)[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC4=CC=C(C=C4)O)C(=O)N[C@@H](CC5=CC=C(C=C5)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC6=CNC=N6)C(=O)N[C@@H](CC7=CC=C(C=C7)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC8=CC=C(C=C8)O)C(=O)N)NC(=O)[C@@H]9CCCN9C(=O)[C@H](CC1=CC=C(C=C1)O)N None
56841989 220199 6 125I-PYY -1 7 Mouse 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C None
CHEMBL4281479 220199 6 125I-PYY -1 7 Mouse 9.5 pKi = 9.5 Binding
NoneNone
PDSP KiDatabase None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C None
None 223267 0 [125I] - Peptide YY 1 3 Guinea pig 9.1 pKi = 9.1 Binding
NoneNone
PDSP KiDatabase 750 15 3 6 5.2 CN(C)CC1CCC(CC1)CN=C(C2=CC=C(C=C2)CC(C(=O)N3CCCC3)NC(=O)C(CC4=CC=CC=C4)NS(=O)(=O)C5=CC6=CC=CC=C6C=C5)N None
1562 7686 13 125I-[Leu31,Pro34]PYY -2 2 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 475 7 3 6 4.6 Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2 None
5312114 7686 13 125I-[Leu31,Pro34]PYY -2 2 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 475 7 3 6 4.6 Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2 None
CHEMBL17645 7686 13 125I-[Leu31,Pro34]PYY -2 2 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 475 7 3 6 4.6 Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2 None
CHEMBL195380 7686 13 125I-[Leu31,Pro34]PYY -2 2 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 475 7 3 6 4.6 Nc1nc(NCC2CCC(CC2)CNS(=O)(=O)c2cccc3c2cccc3)nc2c1cccc2 None
None 223267 0 [125I] - Peptide YY -1 3 Rat 8.9 pKi = 8.9 Binding
NoneNone
PDSP KiDatabase 750 15 3 6 5.2 CN(C)CC1CCC(CC1)CN=C(C2=CC=C(C=C2)CC(C(=O)N3CCCC3)NC(=O)C(CC4=CC=CC=C4)NS(=O)(=O)C5=CC6=CC=CC=C6C=C5)N None
202 8290 77 UNDEFINED -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
60835 8290 77 UNDEFINED -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
972 8290 77 UNDEFINED -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
CHEMBL1175 8290 77 UNDEFINED -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
DB00476 8290 77 UNDEFINED -9 33 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 297 6 1 3 4.6 CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2 None
5656 209845 87 UNDEFINED -7 43 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
CHEMBL637 209845 87 UNDEFINED -7 43 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 277 5 1 3 3.0 COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1 None
54841 209906 52 UNDEFINED -1 30 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
CHEMBL641 209906 52 UNDEFINED -1 30 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 255 6 1 2 3.7 CNCC[C@@H](Oc1ccccc1C)c1ccccc1 None
3075702 224111 0 125I-Peptide YY -2 37 Human 6.0 pKi = 6 Binding
NoneNone
PDSP KiDatabase 198 3 1 3 1.5 C1CNC1COC2=CN=C(C=C2)Cl None
44208932 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
CHEMBL381689 147485 7 UNDEFINED -89125 37 Human 5.0 pKi = 5 Binding
NoneNone
PDSP KiDatabase 475 5 1 3 6.8 Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1 None
None 222835 0 125I-PYY -40738 13 Mouse 6.9 pKi = 6.9 Binding
NoneNone
PDSP KiDatabase None None None None None
None 222835 0 3H-Propionyl-NPY -20892 13 Human 6.8 pKi = 6.8 Binding
NoneNone
PDSP KiDatabase None None None None None
None 222835 0 [125I] - Peptide YY -20892 13 Human 7.7 pKi = 7.7 Binding
NoneNone
PDSP KiDatabase None None None None None
56841989 220199 6 125I-PYY 1 7 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C None
CHEMBL4281479 220199 6 125I-PYY 1 7 Human 8.7 pKi = 8.7 Binding
NoneNone
PDSP KiDatabase None None None CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C None
None 222836 0 125I-PYY -34673 4 Human 6.7 pKi = 6.7 Binding
NoneNone
PDSP KiDatabase None None None None None
21129772 176203 4 [125I] - Peptide YY 1 9 Rat 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 None
CHEMBL44246 176203 4 [125I] - Peptide YY 1 9 Rat 8.5 pKi = 8.5 Binding
NoneNone
PDSP KiDatabase 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 None
21129772 176203 4 [125I] - Peptide YY -1 9 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 None
CHEMBL44246 176203 4 [125I] - Peptide YY -1 9 Guinea pig 8.3 pKi = 8.3 Binding
NoneNone
PDSP KiDatabase 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 None
None 222837 0 125I-PYY -173780 8 Human 6.3 pKi = 6.3 Binding
NoneNone
PDSP KiDatabase 444 3 1 3 7.0 C1C(CC2=CC=CC=C2C1C3=C(OC4=CC=CC=C4C3=O)O)C5=CC=C(C=C5)C6=CC=CC=C6 None
None 222835 0 [125I] - Peptide YY -16595 13 Rhesus macaque 7.3 pKi = 7.3 Binding
NoneNone
PDSP KiDatabase None None None None None
21129772 176203 4 [125I] - Peptide YY -2 9 Rhesus macaque 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 None
CHEMBL44246 176203 4 [125I] - Peptide YY -2 9 Rhesus macaque 8.2 pKi = 8.2 Binding
NoneNone
PDSP KiDatabase 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 None
None 222835 0 125I-PYY -20892 13 Human 7.1 pKi = 7.1 Binding
NoneNone
PDSP KiDatabase None None None None None
21129772 176203 4 [125I] - Peptide YY -2 9 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 None
CHEMBL44246 176203 4 [125I] - Peptide YY -2 9 Human 8.0 pKi = 8.0 Binding
NoneNone
PDSP KiDatabase 473 11 6 4 2.6 N=C(N)NCCCC(NC(=O)C(c1ccccc1)c1ccccc1)C(=O)NCc1ccc(O)cc1 None
None 222837 0 125I-[Leu31,Pro34]PYY -33884 8 Rat 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase 444 3 1 3 7.0 C1C(CC2=CC=CC=C2C1C3=C(OC4=CC=CC=C4C3=O)O)C5=CC=C(C=C5)C6=CC=CC=C6 None
None 222839 0 125I-PYY -1 2 Human 7.0 pKi = 7.0 Binding
NoneNone
PDSP KiDatabase None None None None None
1504 9583 8 None 1 10 Rat 10.5 pKi = 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1518 9583 8 None 1 10 Rat 10.5 pKi = 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1521 9583 8 None 1 10 Rat 10.5 pKi = 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
24868177 9583 8 None 1 10 Rat 10.5 pKi = 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
44288922 9583 8 None 1 10 Rat 10.5 pKi = 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
77068007 9583 8 None 1 10 Rat 10.5 pKi = 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
90479759 9583 8 None 1 10 Rat 10.5 pKi = 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
CHEMBL438945 9583 8 None 1 10 Rat 10.5 pKi = 10.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1485 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562541
1485 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 8886416
1485 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 9145427
3474 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562541
3474 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 8886416
3474 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 9145427
5311023 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562541
5311023 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 8886416
5311023 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 9145427
CHEMBL332347 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562541
CHEMBL332347 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 8886416
CHEMBL332347 7418 31 None -1 4 Rat 8.2 pKi = 8.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 9145427
1485 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562541
1485 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562543
3474 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562541
3474 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562543
5311023 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562541
5311023 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562543
CHEMBL332347 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562541
CHEMBL332347 7418 31 None 1 4 Human 8.7 pKi = 8.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology 473 11 5 4 2.4 O=C([C@H](NC(=O)C(c1ccccc1)c1ccccc1)CCCN=C(N)N)NCc1ccc(cc1)O 7562543
1549 9663 0 None 1 5 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
155817422 9663 0 None 1 5 Rat 9.2 pKi = 9.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1505 9656 0 None 4 4 Rat 10.0 pKi None 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
CHEMBL441396 9656 0 None 4 4 Rat 10.0 pKi None 10 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1527 9084 0 None 1 5 Rat 10.2 pKi None 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1515 9826 0 None 1 6 Rat 10.2 pKi None 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
CHEMBL269503 9826 0 None 1 6 Rat 10.2 pKi None 10.2 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1545 9082 0 None 50 4 Rat 10.6 pKi None 10.6 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1529 8632 0 None 1 5 Rat 10.9 pKi None 10.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1513 9774 0 None -5011 6 Rat 7.0 pKi None 7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1517 10017 0 None -112 3 Rat 7.4 pKi None 7.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1516 10016 0 None -39 5 Rat 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
57339564 10016 0 None -39 5 Rat 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
91898411 10016 0 None -39 5 Rat 7.5 pKi None 7.5 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1510 9666 0 None -31 6 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
155817418 9666 0 None -31 6 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
16142730 9666 0 None -31 6 Rat 7.7 pKi None 7.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1507 9658 0 None -12 7 Rat 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
44351001 9658 0 None -12 7 Rat 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
91929182 9658 0 None -12 7 Rat 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
CHEMBL265849 9658 0 None -12 7 Rat 7.8 pKi None 7.8 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1511 9775 0 None -354 2 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1512 9777 0 None -630 6 Rat 7.9 pKi None 7.9 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 9145427
1530 10436 0 None - 1 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 750 15 3 6 5.2 CN(C[C@@H]1CC[C@@H](CC1)C/N=C(/c1ccc(cc1)C[C@H](C(=O)N1CCCC1)NC(=O)[C@H](NS(=O)(=O)c1ccc2c(c1)cccc2)Cc1ccccc1)\N)C 16097949
5312150 10436 0 None - 1 Human 8.4 pKi None 8.4 Binding
UnclassifiedUnclassified
Guide to Pharmacology 750 15 3 6 5.2 CN(C[C@@H]1CC[C@@H](CC1)C/N=C(/c1ccc(cc1)C[C@H](C(=O)N1CCCC1)NC(=O)[C@H](NS(=O)(=O)c1ccc2c(c1)cccc2)Cc1ccccc1)\N)C 16097949
1505 9656 0 None -6 4 Human 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16097949
CHEMBL441396 9656 0 None -6 4 Human 9.7 pKi None 9.7 Binding
UnclassifiedUnclassified
Guide to Pharmacology None None None None 16097949