Ligand source activities (1 row/activity)





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Ligands Receptor Assay information Chemical information
Sel. page Common
name
GPCRdb ID #Vendors Reference
ligand
Fold selectivity
(Potency)
# tested GPCRs
(Potency)
Species p-value
(-log)
Type Activity
Relation
Activity
Value
Assay Type Assay Description Source Mol
weight
Rot
Bonds
H don H acc LogP Smiles DOI
93149 106717 78 None -1 3 Human 6.0 pEC50 = 6 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
CHEMBL316589 106717 78 None -1 3 Human 6.0 pEC50 = 6 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
336912 83370 26 None - 1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1 10.1021/jm301121j
CHEMBL2205802 83370 26 None - 1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1 10.1021/jm301121j
2733927 83375 90 None -1 3 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
CHEMBL2205808 83375 90 None -1 3 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
667748 83372 78 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
CHEMBL2205805 83372 78 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
20445 83373 105 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
CHEMBL2205806 83373 105 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
667748 83372 78 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
CHEMBL2205805 83372 78 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
15783796 83378 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83378 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
602123 83371 50 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
CHEMBL2205803 83371 50 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
20445 83373 105 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
CHEMBL2205806 83373 105 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
15783796 83378 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83378 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
602123 83371 50 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
CHEMBL2205803 83371 50 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
74265 206606 107 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 206606 107 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
353741 71720 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
CHEMBL1976682 71720 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
65237 137099 97 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 137099 97 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
74265 206606 107 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 206606 107 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
353741 71720 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
CHEMBL1976682 71720 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
15664 83374 93 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83374 93 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
65237 137099 97 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 137099 97 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
15664 83374 93 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83374 93 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
72791 206499 71 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL98682 206499 71 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
77865 106802 76 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL317115 106802 76 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
72791 206499 71 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL98682 206499 71 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
12041800 201799 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
ChEMBL 410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 10.1016/j.bmcl.2011.11.014
CHEMBL66165 201799 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
ChEMBL 410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 10.1016/j.bmcl.2011.11.014
77865 106802 76 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL317115 106802 76 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
1474 153865 133 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 153865 133 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
1474 153865 133 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 153865 133 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
14338 4302 115 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4302 115 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
14338 4302 115 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4302 115 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
12987698 83376 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83376 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
14434082 83369 11 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83369 11 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
14434082 83369 11 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83369 11 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
12987698 83376 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83376 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
12425 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
1318 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
CHEMBL415879 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
DB02365 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
12425 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
1318 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
CHEMBL415879 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
DB02365 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
70848 204945 105 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 204945 105 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
70848 204945 105 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 204945 105 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
72792 198041 76 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 198041 76 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
72792 198041 76 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 198041 76 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
11151928 188897 0 None -1 4 Human 9.8 pED50 = 9.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assay
ChEMBL 338 11 2 2 4.3 CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O 10.1021/jm900133w
CHEMBL513863 188897 0 None -1 4 Human 9.8 pED50 = 9.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assay
ChEMBL 338 11 2 2 4.3 CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O 10.1021/jm900133w
10456104 71638 0 None 56 2 Human 10.0 pIC50 = 10 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71638 0 None 56 2 Human 10.0 pIC50 = 10 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
59278332 170505 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4457209 170505 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
59278286 170989 1 None 112 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 170989 1 None 112 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
45138759 171771 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4475581 171771 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
512282 747 55 None 9 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 747 55 None 9 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 747 55 None 9 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
6918497 112931 1 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 112931 1 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 112931 1 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
66686405 174667 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
CHEMBL4571977 174667 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
9980155 71472 0 None 23 2 Human 9.1 pIC50 = 9.1 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71472 0 None 23 2 Human 9.1 pIC50 = 9.1 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
10003548 71628 0 None 223 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71628 0 None 223 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
11743399 72138 12 None 32 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72138 12 None 32 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405176 134882 0 None 1 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL372807 134882 0 None 1 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44309143 201797 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN 10.1016/j.bmcl.2004.02.022
CHEMBL66159 201797 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN 10.1016/j.bmcl.2004.02.022
59278147 172425 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4518015 172425 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2018.12.024
512282 747 55 None 9 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
767 747 55 None 9 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
CHEMBL232656 747 55 None 9 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
59278115 174263 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4562738 174263 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
512282 747 55 None 9 3 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
767 747 55 None 9 3 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
CHEMBL232656 747 55 None 9 3 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
10434371 72611 0 None 5 2 Human 8.8 pIC50 = 8.8 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72611 0 None 5 2 Human 8.8 pIC50 = 8.8 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
52916803 170415 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4456123 170415 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.1016/j.bmcl.2018.12.024
155511620 169019 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
CHEMBL4436061 169019 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
11554849 72507 0 None 2 2 Human 8.0 pIC50 = 8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72507 0 None 2 2 Human 8.0 pIC50 = 8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453265 94942 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL256821 94942 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 10.1016/j.bmcl.2007.09.068
44453400 95089 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL257509 95089 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl 10.1016/j.bmcl.2007.09.068
10003548 71628 0 None 223 2 Human 7.0 pIC50 = 7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71628 0 None 223 2 Human 7.0 pIC50 = 7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
10072252 72273 0 None -17 2 Mouse 6.0 pIC50 = 6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72273 0 None -17 2 Mouse 6.0 pIC50 = 6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405203 72141 0 None 31 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72141 0 None 31 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44405202 72648 0 None 17 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72648 0 None 17 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
76322249 105699 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3137848 105699 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138130 209373 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138370 209373 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
44453225 95294 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL258368 95294 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10003548 71628 0 None 223 2 Human 5.0 pIC50 = 5.0 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71628 0 None 223 2 Human 5.0 pIC50 = 5.0 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
10789018 34950 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm990316l
CHEMBL143499 34950 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm990316l
44453503 94636 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 10.1016/j.bmcl.2007.09.068
CHEMBL255338 94636 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 10.1016/j.bmcl.2007.09.068
58138765 173843 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4552741 173843 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 10.1016/j.bmcl.2018.12.024
44309194 201845 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL66457 201845 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
44430752 87569 0 None 7 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87569 0 None 7 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44430752 87569 0 None 7 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87569 0 None 7 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
59278305 169465 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4442765 169465 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
59278307 170985 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464575 170985 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
44470374 175303 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 10.1016/j.bmcl.2018.12.024
CHEMBL4586189 175303 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 10.1016/j.bmcl.2018.12.024
44453162 94826 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
CHEMBL256272 94826 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
44453199 95223 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258064 95223 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmcl.2007.09.068
44469804 171452 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
CHEMBL4471579 171452 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
44405203 72141 0 None 31 2 Human 6.9 pIC50 = 6.9 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72141 0 None 31 2 Human 6.9 pIC50 = 6.9 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44309407 102491 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 10.1016/j.bmcl.2004.02.022
CHEMBL306457 102491 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 10.1016/j.bmcl.2004.02.022
44468442 169984 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4450029 169984 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
155530458 170973 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2018.11.015
CHEMBL4464403 170973 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2018.11.015
44468440 172786 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4527255 172786 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44453357 97074 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270419 97074 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453525 97054 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270358 97054 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44309161 202344 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 10.1016/j.bmcl.2004.02.022
CHEMBL69876 202344 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 10.1016/j.bmcl.2004.02.022
CHEMBL3138123 209371 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CSCC[C@H](NC(=O)c1cc(C(=CCC[C@H]2CC[C@@]3(C)C(CC[C@@H]4[C@@H]3CC[C@@]3(C)[C@H]4CC[C@@H]3C(C)CCCC(C)C)C2)c2cc(Cl)c(O)c(C(=O)N[C@@H](CCSC)C(=O)O)c2)cc(Cl)c1O)C(=O)O 10.1016/s0960-894x(00)00601-6
44453638 165929 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL427834 165929 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44430746 86689 0 None -1 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232638 86689 0 None -1 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
155564974 174904 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
CHEMBL4577357 174904 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
10388824 132917 0 None 4 2 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 132917 0 None 4 2 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44309397 202112 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL68366 202112 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
44453320 97040 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270253 97040 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453579 155048 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404465 155048 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44309364 202222 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.022
CHEMBL69123 202222 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.022
44453615 94721 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL255797 94721 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44453402 95129 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL257698 95129 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 10.1016/j.bmcl.2007.09.068
10456104 71638 0 None 56 2 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71638 0 None 56 2 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44430723 86413 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232253 86413 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453614 154726 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL402825 154726 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
24758044 82450 0 None 14 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
ChEMBL 398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180528 82450 0 None 14 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
ChEMBL 398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
44480600 174489 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4568048 174489 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.11.015
44405212 72622 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72622 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
10001921 72108 0 None 3 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72108 0 None 3 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
512282 747 55 None -147 3 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 747 55 None -147 3 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 747 55 None -147 3 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
10388824 132917 0 None 4 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 132917 0 None 4 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
49865900 16007 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224118 16007 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
24782574 178782 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
CHEMBL473734 178782 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
9980155 71472 0 None 23 2 Human 7.8 pIC50 = 7.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71472 0 None 23 2 Human 7.8 pIC50 = 7.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
44405234 132769 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370447 132769 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10575889 33468 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL142199 33468 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
44453084 94824 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 6 2 3 4.6 O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
CHEMBL256264 94824 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 6 2 3 4.6 O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
44430713 86289 0 None 2 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL231829 86289 0 None 2 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
58138868 169980 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1 10.1016/j.bmcl.2018.12.024
CHEMBL4449996 169980 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1 10.1016/j.bmcl.2018.12.024
58138852 173493 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 7 2 5 3.4 CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4544186 173493 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 7 2 5 3.4 CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
58138832 169309 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.9 COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4440452 169309 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.9 COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
155544726 174368 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4565390 174368 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44405194 71489 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 427 5 1 3 3.9 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
CHEMBL196908 71489 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 427 5 1 3 3.9 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
44405181 132303 0 None 51 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132303 0 None 51 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
512282 747 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
767 747 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
CHEMBL232656 747 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
512282 747 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
767 747 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
CHEMBL232656 747 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
44430713 86289 0 None 2 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL231829 86289 0 None 2 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453467 95288 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL258359 95288 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453363 97077 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 10.1016/j.bmcl.2007.09.068
CHEMBL270433 97077 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 10.1016/j.bmcl.2007.09.068
44453501 97357 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL271903 97357 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453292 154941 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 448 4 1 4 3.8 Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404033 154941 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 448 4 1 4 3.8 Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
58138893 174913 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4577460 174913 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
11801020 12142 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
CHEMBL1184558 12142 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
CHEMBL356099 12142 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
22725647 173127 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4535696 173127 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
44430745 141519 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387822 141519 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
45138458 171122 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 1 7 2.7 CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4466500 171122 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 1 7 2.7 CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
44453164 95290 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F 10.1016/j.bmcl.2007.09.068
CHEMBL258361 95290 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F 10.1016/j.bmcl.2007.09.068
10001921 72108 0 None 3 2 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72108 0 None 3 2 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
155533145 171255 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 4 1 2 6.3 Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4468514 171255 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 4 1 2 6.3 Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2018.11.015
10766998 33801 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 476 7 1 4 5.5 COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br 10.1021/jm990316l
CHEMBL142468 33801 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 476 7 1 4 5.5 COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br 10.1021/jm990316l
22725647 173127 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4535696 173127 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
10164 861 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
135565361 861 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
CHEMBL4444976 861 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
52917500 171702 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 465 5 1 7 3.2 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4474606 171702 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 465 5 1 7 3.2 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1 10.1016/j.bmcl.2018.12.024
59278436 171740 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 2 6 2.4 CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4475173 171740 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 2 6 2.4 CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
10049340 102170 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 448 11 3 5 3.3 CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL304358 102170 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 448 11 3 5 3.3 CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
512282 747 55 None 9 3 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 747 55 None 9 3 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 747 55 None 9 3 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
44405181 132303 0 None 51 2 Human 8.6 pIC50 = 8.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132303 0 None 51 2 Human 8.6 pIC50 = 8.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
49865951 16023 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 463 4 1 4 5.7 Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224189 16023 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 463 4 1 4 5.7 Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
10072252 72273 0 None 17 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72273 0 None 17 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10434371 72611 0 None 5 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72611 0 None 5 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
11719164 139739 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL380568 139739 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453637 97540 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL272758 97540 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
6918497 112931 1 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 112931 1 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 112931 1 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
44453229 94955 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 426 7 2 4 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL256889 94955 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 426 7 2 4 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1016/j.bmcl.2007.09.068
58138845 175549 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 429 4 1 3 5.6 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4591935 175549 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 429 4 1 3 5.6 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.12.024
155562877 174654 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4571547 174654 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
25254218 16009 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224120 16009 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
24782826 188995 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL514611 188995 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.07.082
25233755 178757 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 457 4 1 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F 10.1021/jm801416q
CHEMBL473532 178757 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 457 4 1 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F 10.1021/jm801416q
24782826 188995 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1021/jm801416q
CHEMBL514611 188995 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1021/jm801416q
58138826 169834 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4448064 169834 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44309195 101678 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 496 9 3 5 3.6 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 10.1016/j.bmcl.2004.02.022
CHEMBL302533 101678 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 496 9 3 5 3.6 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 10.1016/j.bmcl.2004.02.022
44453167 95292 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258363 95292 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
44453195 154637 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 496 4 1 4 4.8 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL402327 154637 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 496 4 1 4 4.8 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453197 154874 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL403665 154874 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
44430748 86793 0 None 1 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232837 86793 0 None 1 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453504 95083 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 10.1016/j.bmcl.2007.09.068
CHEMBL257452 95083 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 10.1016/j.bmcl.2007.09.068
10003548 71628 0 None -223 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71628 0 None -223 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
52916803 170415 14 None - 1 Human 7.6 pIC50 = 7.6 Functional
Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 nan
CHEMBL4456123 170415 14 None - 1 Human 7.6 pIC50 = 7.6 Functional
Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 nan
46858281 170842 3 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 394 4 1 4 4.2 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4462565 170842 3 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 394 4 1 4 4.2 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44453433 160292 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL411476 160292 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2007.09.068
44430723 86413 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232253 86413 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44469380 169679 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F 10.1016/j.bmcl.2018.12.024
CHEMBL4445779 169679 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F 10.1016/j.bmcl.2018.12.024
9889700 118083 13 None 11 4 Human 5.6 pIC50 = 5.6 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL34166 118083 13 None 11 4 Human 5.6 pIC50 = 5.6 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
44453464 94857 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256449 94857 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
58138911 174042 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 463 4 1 3 6.3 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4557554 174042 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 463 4 1 3 6.3 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.12.024
76336764 105706 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 766 12 4 4 12.8 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138187 105706 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 766 12 4 4 12.8 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138134 209374 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138376 209374 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
44453157 154728 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL402827 154728 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
155538947 172215 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 4 1 3 5.5 Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4513370 172215 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 4 1 3 5.5 Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44405203 72141 0 None 31 2 Human 7.6 pIC50 = 7.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72141 0 None 31 2 Human 7.6 pIC50 = 7.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44453161 94825 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL256271 94825 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
44453435 97152 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL270863 97152 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2007.09.068
44537841 668 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
57889181 668 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
9497 668 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL2398716 668 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL3334824 668 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
45138007 169885 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4448761 169885 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
71462570 82154 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assayAntagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assay
ChEMBL 518 5 2 5 5.6 CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O 10.1021/jm300682j
CHEMBL2178569 82154 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assayAntagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assay
ChEMBL 518 5 2 5 5.6 CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O 10.1021/jm300682j
44453403 94693 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL255629 94693 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl 10.1016/j.bmcl.2007.09.068
44453202 94849 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256404 94849 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
11743399 72138 12 None 32 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72138 12 None 32 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10072252 72273 0 None 17 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72273 0 None 17 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
11554849 72507 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72507 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44405211 133070 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
CHEMBL371248 133070 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
9980155 71472 0 None -23 2 Mouse 6.5 pIC50 = 6.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71472 0 None -23 2 Mouse 6.5 pIC50 = 6.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
10072252 72273 0 None 17 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72273 0 None 17 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405202 72648 0 None -17 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72648 0 None -17 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
44405181 132303 0 None -51 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132303 0 None -51 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
9804868 33616 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 5 1 4 6.0 N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 10.1021/jm990316l
CHEMBL142318 33616 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 5 1 4 6.0 N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 10.1021/jm990316l
44309122 102347 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 482 11 4 6 3.4 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO 10.1016/j.bmcl.2004.02.022
CHEMBL305423 102347 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 482 11 4 6 3.4 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO 10.1016/j.bmcl.2004.02.022
1370410 86474 11 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 404 3 0 4 3.4 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2013.01.005
CHEMBL2322888 86474 11 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 404 3 0 4 3.4 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2013.01.005
11743399 72138 12 None 32 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72138 12 None 32 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10811393 34662 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 407 7 1 4 4.8 N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm990316l
CHEMBL143194 34662 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 407 7 1 4 4.8 N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm990316l
44453227 94953 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256887 94953 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10649043 34331 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 499 5 1 4 5.5 CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 10.1021/jm990316l
CHEMBL142925 34331 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 499 5 1 4 5.5 CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 10.1021/jm990316l
45138010 170292 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
CHEMBL4454067 170292 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
25233754 178756 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl 10.1021/jm801416q
CHEMBL473531 178756 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl 10.1021/jm801416q
44453469 95289 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL258360 95289 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2007.09.068
155526212 170470 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 406 4 1 2 5.7 Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4456839 170470 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 406 4 1 2 5.7 Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44453437 160293 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL411477 160293 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2007.09.068
44405180 140102 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 431 6 1 3 4.1 CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL381446 140102 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 431 6 1 3 4.1 CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44453165 95291 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258362 95291 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
44453263 155101 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL404732 155101 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2007.09.068
44430755 152891 0 None 5 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL397910 152891 0 None 5 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453528 97091 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 10.1016/j.bmcl.2007.09.068
CHEMBL270564 97091 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 10.1016/j.bmcl.2007.09.068
44430753 141491 0 None 1 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387608 141491 0 None 1 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
25252974 16022 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224188 16022 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
17753030 86583 0 None 3 3 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232441 86583 0 None 3 3 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
10434371 72611 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72611 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44405176 134882 0 None -1 2 Mouse 8.4 pIC50 = 8.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL372807 134882 0 None -1 2 Mouse 8.4 pIC50 = 8.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
58138789 171745 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4475237 171745 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
21070989 86461 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86461 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
44453291 96973 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL269957 96973 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
44453361 166769 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 456 7 2 4 4.0 Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL429419 166769 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 456 7 2 4 4.0 Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
512282 747 55 None 9 3 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 747 55 None 9 3 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 747 55 None 9 3 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
11554849 72507 0 None -2 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72507 0 None -2 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
9980155 71472 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71472 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
9845614 120769 22 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 430 6 1 3 5.5 N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL357919 120769 22 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 430 6 1 3 5.5 N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL3138115 209376 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138540 209376 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
59278474 171566 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 6 1 7 2.8 O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4472994 171566 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 6 1 7 2.8 O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
11554849 72507 0 None 2 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72507 0 None 2 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453321 97041 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270254 97041 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
155561040 174801 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 418 6 2 5 2.7 CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4574870 174801 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 418 6 2 5 2.7 CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1 10.1016/j.bmcl.2018.11.015
44453290 96972 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL269956 96972 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
59278286 170989 1 None -112 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 170989 1 None -112 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
44469942 174374 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4565496 174374 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
25233582 189509 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 401 5 1 3 4.0 COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 10.1021/jm801416q
CHEMBL517290 189509 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 401 5 1 3 4.0 COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 10.1021/jm801416q
44309245 201752 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 556 13 3 5 5.2 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 10.1016/j.bmcl.2004.02.022
CHEMBL65784 201752 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 556 13 3 5 5.2 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 10.1016/j.bmcl.2004.02.022
10001921 72108 0 None -3 2 Mouse 6.4 pIC50 = 6.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72108 0 None -3 2 Mouse 6.4 pIC50 = 6.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
9980155 71472 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71472 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
45138012 169642 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4445316 169642 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
58138781 174530 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 379 4 1 3 4.7 O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4568987 174530 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 379 4 1 3 4.7 O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44453198 95173 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 516 4 1 4 5.2 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL257853 95173 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 516 4 1 4 5.2 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
44430746 86689 0 None -1 3 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232638 86689 0 None -1 3 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44480348 175205 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1ccc(S(C)(=O)=O)nc1 10.1016/j.bmcl.2018.11.015
CHEMBL4583870 175205 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1ccc(S(C)(=O)=O)nc1 10.1016/j.bmcl.2018.11.015
44453639 158318 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL409498 158318 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44405203 72141 0 None -31 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72141 0 None -31 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
10503785 120606 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 451 7 1 4 5.3 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 10.1021/jm990316l
CHEMBL357434 120606 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 451 7 1 4 5.3 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 10.1021/jm990316l
59687824 82157 1 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 469 5 1 5 3.6 CO[C@@H]1COCC[C@@H]1NC1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1 10.1021/jm300682j
CHEMBL2178572 82157 1 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 469 5 1 5 3.6 CO[C@@H]1COCC[C@@H]1NC1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1 10.1021/jm300682j
44430753 141491 0 None 1 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387608 141491 0 None 1 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44470083 171012 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4465000 171012 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
44309312 202082 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 460 9 3 5 3.4 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 10.1016/j.bmcl.2004.02.022
CHEMBL68145 202082 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 460 9 3 5 3.4 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 10.1016/j.bmcl.2004.02.022
21070989 86461 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86461 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
44453200 95224 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2007.09.068
CHEMBL258065 95224 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2007.09.068
44405181 132303 0 None 51 2 Human 7.3 pIC50 = 7.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132303 0 None 51 2 Human 7.3 pIC50 = 7.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10434371 72611 0 None -5 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72611 0 None -5 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44405212 72622 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72622 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
155549724 173289 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4539264 173289 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.11.015
10388824 132917 0 None -4 2 Mouse 6.3 pIC50 = 6.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 132917 0 None -4 2 Mouse 6.3 pIC50 = 6.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
9870185 83682 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2207666 83682 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
162658125 180514 0 None -125 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 10.1021/acs.jmedchem.0c01137
CHEMBL4760108 180514 0 None -125 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 10.1021/acs.jmedchem.0c01137
162666730 181692 0 None -707 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 589 9 2 6 6.5 N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.0c01137
CHEMBL4783861 181692 0 None -707 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 589 9 2 6 6.5 N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.0c01137
44453436 97198 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
CHEMBL271079 97198 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
44453293 166850 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
CHEMBL429591 166850 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
9869274 118808 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 468 5 1 3 6.4 N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 10.1021/jm990316l
CHEMBL344073 118808 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 468 5 1 3 6.4 N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 10.1021/jm990316l
44430745 141519 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387822 141519 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
10111333 174894 0 None -19 2 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4577133 174894 0 None -19 2 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
58138841 169069 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4437170 169069 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
512282 747 55 None 9 3 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 747 55 None 9 3 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 747 55 None 9 3 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
44405202 72648 0 None 17 2 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72648 0 None 17 2 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
10576419 33976 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 9 1 3 6.7 N#CC(CCCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL142620 33976 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 9 1 3 6.7 N#CC(CCCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL3138380 209375 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138437 209375 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
10001921 72108 0 None 3 2 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72108 0 None 3 2 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
11743399 72138 12 None -32 2 Mouse 6.2 pIC50 = 6.2 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72138 12 None -32 2 Mouse 6.2 pIC50 = 6.2 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10572669 118936 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 393 6 1 4 4.6 N#Cc1ccccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
CHEMBL344989 118936 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 393 6 1 4 4.6 N#Cc1ccccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
3497 1158 20 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 482 11 4 6 2.5 O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C 10.1016/j.bmcl.2018.11.015
5311123 1158 20 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 482 11 4 6 2.5 O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL1628706 1158 20 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 482 11 4 6 2.5 O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C 10.1016/j.bmcl.2018.11.015
44453499 154864 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 4 1 4 4.3 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL403613 154864 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 4 1 4 4.3 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10111333 174894 0 None -19 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4577133 174894 0 None -19 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
44430748 86793 0 None 1 3 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232837 86793 0 None 1 3 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44430758 142278 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 482 6 2 6 3.1 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL389293 142278 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 482 6 2 6 3.1 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
25233756 180300 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 467 4 1 2 5.6 Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
CHEMBL475748 180300 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 467 4 1 2 5.6 Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
58138880 171786 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4475918 171786 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
44405212 72622 0 None 1 2 Human 8.2 pIC50 = 8.2 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72622 0 None 1 2 Human 8.2 pIC50 = 8.2 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
25253284 16008 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 450 4 1 5 4.8 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224119 16008 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 450 4 1 5 4.8 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
59278314 169351 16 None 54 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4441094 169351 16 None 54 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
11211557 169287 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 393 4 1 3 4.8 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4440166 169287 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 393 4 1 3 4.8 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
10456104 71638 0 None -56 2 Mouse 6.2 pIC50 = 6.2 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71638 0 None -56 2 Mouse 6.2 pIC50 = 6.2 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
59278235 172516 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cncc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4519965 172516 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cncc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
44468708 174119 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 423 5 1 5 3.5 CS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4559388 174119 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 423 5 1 5 3.5 CS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
44453466 155109 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 4 1 4 4.3 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404757 155109 0 None - 1 Human