Ligand source activities (1 row/activity)



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Ligands (move mouse cursor over ligand name to see structure) Receptor Assay information Chemical information
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name		 GPCRdb
ID		 #Vendors

 Reference
ligand		 Fold
selectivity		 # Tested
GPCRs		 Species

 p-value
(-log)		 Activity
Type		 Activity
Relation		 Activity
Value		 AssayType

 Assay
Description		 Source

 Mol
weight		 Rot
Bonds		 H don

 H acc

 LogP

 Smiles

 DOI
93149 107201 84 None -1 3 Human 6.0 pEC50 = 6 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
CHEMBL316589 107201 84 None -1 3 Human 6.0 pEC50 = 6 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
336912 83784 30 None - 1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1 10.1021/jm301121j
CHEMBL2205802 83784 30 None - 1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1 10.1021/jm301121j
2733927 83789 97 None -1 3 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
CHEMBL2205808 83789 97 None -1 3 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
667748 83786 86 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
CHEMBL2205805 83786 86 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
20445 83787 115 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
CHEMBL2205806 83787 115 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
667748 83786 86 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
CHEMBL2205805 83786 86 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
15783796 83792 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83792 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
602123 83785 55 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
CHEMBL2205803 83785 55 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
20445 83787 115 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
CHEMBL2205806 83787 115 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
15783796 83792 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83792 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
602123 83785 55 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
CHEMBL2205803 83785 55 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
74265 208347 115 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 208347 115 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
353741 72064 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
CHEMBL1976682 72064 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
65237 137624 105 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 137624 105 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
74265 208347 115 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 208347 115 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
353741 72064 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
CHEMBL1976682 72064 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
15664 83788 101 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83788 101 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
65237 137624 105 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 137624 105 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
15664 83788 101 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83788 101 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
72791 208240 76 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL98682 208240 76 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
77865 107286 82 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL317115 107286 82 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
72791 208240 76 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL98682 208240 76 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
12041800 203493 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
ChEMBL 410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 10.1016/j.bmcl.2011.11.014
CHEMBL66165 203493 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
ChEMBL 410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 10.1016/j.bmcl.2011.11.014
77865 107286 82 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL317115 107286 82 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
1474 154399 142 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 154399 142 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
1474 154399 142 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 154399 142 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
14338 4368 124 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4368 124 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
14338 4368 124 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4368 124 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
12987698 83790 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83790 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
14434082 83783 17 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83783 17 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
14434082 83783 17 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83783 17 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
12987698 83790 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83790 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
12425 6 126 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
1318 6 126 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
CHEMBL415879 6 126 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
DB02365 6 126 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
12425 6 126 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
1318 6 126 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
CHEMBL415879 6 126 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
DB02365 6 126 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
70848 206672 112 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 206672 112 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
70848 206672 112 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 206672 112 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
72792 199723 84 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 199723 84 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
72792 199723 84 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 199723 84 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
11151928 189487 0 None -1 4 Human 9.8 pED50 = 9.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assay
ChEMBL 338 11 2 2 4.3 CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O 10.1021/jm900133w
CHEMBL513863 189487 0 None -1 4 Human 9.8 pED50 = 9.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assay
ChEMBL 338 11 2 2 4.3 CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O 10.1021/jm900133w
10456104 71982 0 None 56 2 Human 10.0 pIC50 = 10 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71982 0 None 56 2 Human 10.0 pIC50 = 10 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
59278332 171072 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4457209 171072 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
59278286 171555 1 None 112 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 171555 1 None 112 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
45138759 172337 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4475581 172337 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
512282 758 59 None 141 2 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 758 59 None 141 2 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 758 59 None 141 2 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
6918497 113430 2 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 113430 2 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 113430 2 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
66686405 175239 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
CHEMBL4571977 175239 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
9980155 71816 0 None 23 2 Human 9.1 pIC50 = 9.1 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71816 0 None 23 2 Human 9.1 pIC50 = 9.1 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
10003548 71972 0 None 223 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71972 0 None 223 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
11743399 72483 12 None 32 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72483 12 None 32 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405176 135405 0 None 1 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL372807 135405 0 None 1 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44309143 203491 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN 10.1016/j.bmcl.2004.02.022
CHEMBL66159 203491 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN 10.1016/j.bmcl.2004.02.022
59278147 172994 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4518015 172994 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2018.12.024
512282 758 59 None 141 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
767 758 59 None 141 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
CHEMBL232656 758 59 None 141 2 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
59278115 174835 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4562738 174835 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
512282 758 59 None 141 2 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
767 758 59 None 141 2 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
CHEMBL232656 758 59 None 141 2 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
10434371 72957 0 None 5 2 Human 8.8 pIC50 = 8.8 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72957 0 None 5 2 Human 8.8 pIC50 = 8.8 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
52916803 170982 18 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4456123 170982 18 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.1016/j.bmcl.2018.12.024
155511620 169586 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
CHEMBL4436061 169586 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
11554849 72852 0 None 2 2 Human 8.0 pIC50 = 8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72852 0 None 2 2 Human 8.0 pIC50 = 8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453265 95386 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL256821 95386 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 10.1016/j.bmcl.2007.09.068
44453400 95533 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL257509 95533 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl 10.1016/j.bmcl.2007.09.068
10003548 71972 0 None 223 2 Human 7.0 pIC50 = 7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71972 0 None 223 2 Human 7.0 pIC50 = 7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
10072252 72618 0 None -17 2 Mouse 6.0 pIC50 = 6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72618 0 None -17 2 Mouse 6.0 pIC50 = 6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405203 72486 0 None 31 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72486 0 None 31 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44405202 72994 0 None 17 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72994 0 None 17 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
76322249 106180 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3137848 106180 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138130 211119 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138370 211119 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
44453225 95738 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL258368 95738 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10003548 71972 0 None 223 2 Human 5.0 pIC50 = 5.0 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71972 0 None 223 2 Human 5.0 pIC50 = 5.0 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
10789018 35176 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm990316l
CHEMBL143499 35176 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm990316l
44453503 95079 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 10.1016/j.bmcl.2007.09.068
CHEMBL255338 95079 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 10.1016/j.bmcl.2007.09.068
58138765 174415 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4552741 174415 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 10.1016/j.bmcl.2018.12.024
44309194 203539 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL66457 203539 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
44430752 87997 0 None 147 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87997 0 None 147 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44430752 87997 0 None 147 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87997 0 None 147 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
59278305 170032 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4442765 170032 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
59278307 171551 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464575 171551 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
44470374 175876 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 10.1016/j.bmcl.2018.12.024
CHEMBL4586189 175876 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 10.1016/j.bmcl.2018.12.024
44453162 95270 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
CHEMBL256272 95270 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
44453199 95667 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258064 95667 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmcl.2007.09.068
44469804 172018 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
CHEMBL4471579 172018 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
44405203 72486 0 None 31 2 Human 6.9 pIC50 = 6.9 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72486 0 None 31 2 Human 6.9 pIC50 = 6.9 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44309407 102964 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 10.1016/j.bmcl.2004.02.022
CHEMBL306457 102964 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 10.1016/j.bmcl.2004.02.022
44468442 170551 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4450029 170551 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
155530458 171539 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2018.11.015
CHEMBL4464403 171539 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2018.11.015
44468440 173358 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4527255 173358 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44453357 97523 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270419 97523 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453525 97503 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270358 97503 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44309161 204042 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 10.1016/j.bmcl.2004.02.022
CHEMBL69876 204042 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 10.1016/j.bmcl.2004.02.022
CHEMBL3138123 211117 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CSCC[C@H](NC(=O)c1cc(C(=CCC[C@H]2CC[C@@]3(C)C(CC[C@@H]4[C@@H]3CC[C@@]3(C)[C@H]4CC[C@@H]3C(C)CCCC(C)C)C2)c2cc(Cl)c(O)c(C(=O)N[C@@H](CCSC)C(=O)O)c2)cc(Cl)c1O)C(=O)O 10.1016/s0960-894x(00)00601-6
44453638 166482 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL427834 166482 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44430746 87117 0 None 41 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232638 87117 0 None 41 2 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
155564974 175477 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
CHEMBL4577357 175477 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
10388824 133438 0 None 4 2 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 133438 0 None 4 2 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44309397 203809 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL68366 203809 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
44453320 97489 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270253 97489 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453579 155588 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404465 155588 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44309364 203920 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.022
CHEMBL69123 203920 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.022
44453615 95164 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL255797 95164 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44453402 95573 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL257698 95573 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 10.1016/j.bmcl.2007.09.068
10456104 71982 0 None 56 2 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71982 0 None 56 2 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44430723 86841 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232253 86841 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453614 155265 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL402825 155265 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
24758044 82863 0 None 14 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
ChEMBL 398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180528 82863 0 None 14 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
ChEMBL 398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
44480600 175061 1 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4568048 175061 1 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.11.015
44405212 72968 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72968 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
10001921 72453 0 None 3 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72453 0 None 3 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
512282 758 59 None -141 2 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 758 59 None -141 2 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 758 59 None -141 2 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
10388824 133438 0 None 4 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 133438 0 None 4 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
49865900 16183 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224118 16183 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
24782574 179362 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
CHEMBL473734 179362 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
9980155 71816 0 None 23 2 Human 7.8 pIC50 = 7.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71816 0 None 23 2 Human 7.8 pIC50 = 7.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
44405234 133290 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370447 133290 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10575889 33689 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL142199 33689 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
44453084 95268 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 6 2 3 4.6 O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
CHEMBL256264 95268 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 6 2 3 4.6 O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
44430713 86716 0 None 30 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL231829 86716 0 None 30 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
58138868 170548 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1 10.1016/j.bmcl.2018.12.024
CHEMBL4449996 170548 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1 10.1016/j.bmcl.2018.12.024
58138852 174065 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 7 2 5 3.4 CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4544186 174065 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 7 2 5 3.4 CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
58138832 169876 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.9 COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4440452 169876 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.9 COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
155544726 174940 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4565390 174940 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44405194 71833 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 427 5 1 3 3.9 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
CHEMBL196908 71833 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 427 5 1 3 3.9 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
44405181 132824 0 None 51 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132824 0 None 51 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
512282 758 59 None 141 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
767 758 59 None 141 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
CHEMBL232656 758 59 None 141 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
512282 758 59 None 141 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
767 758 59 None 141 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
CHEMBL232656 758 59 None 141 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
44430713 86716 0 None 30 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL231829 86716 0 None 30 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453467 95732 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL258359 95732 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453363 97526 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 10.1016/j.bmcl.2007.09.068
CHEMBL270433 97526 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 10.1016/j.bmcl.2007.09.068
44453501 97806 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL271903 97806 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453292 155479 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 448 4 1 4 3.8 Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404033 155479 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 448 4 1 4 3.8 Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
58138893 175486 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4577460 175486 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
11801020 12248 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
CHEMBL1184558 12248 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
CHEMBL356099 12248 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
22725647 173699 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4535696 173699 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
44430745 142051 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387822 142051 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
45138458 171688 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 1 7 2.7 CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4466500 171688 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 1 7 2.7 CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
44453164 95734 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F 10.1016/j.bmcl.2007.09.068
CHEMBL258361 95734 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F 10.1016/j.bmcl.2007.09.068
10001921 72453 0 None 3 2 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72453 0 None 3 2 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
155533145 171821 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 4 1 2 6.3 Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4468514 171821 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 4 1 2 6.3 Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2018.11.015
10766998 34023 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 476 7 1 4 5.5 COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br 10.1021/jm990316l
CHEMBL142468 34023 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 476 7 1 4 5.5 COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br 10.1021/jm990316l
22725647 173699 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4535696 173699 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
10164 874 24 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
135565361 874 24 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
CHEMBL4444976 874 24 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
52917500 172268 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 465 5 1 7 3.2 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4474606 172268 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 465 5 1 7 3.2 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1 10.1016/j.bmcl.2018.12.024
59278436 172306 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 2 6 2.4 CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4475173 172306 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 2 6 2.4 CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
10049340 102643 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 448 11 3 5 3.3 CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL304358 102643 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 448 11 3 5 3.3 CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
512282 758 59 None 141 2 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 758 59 None 141 2 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 758 59 None 141 2 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
44405181 132824 0 None 51 2 Human 8.6 pIC50 = 8.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132824 0 None 51 2 Human 8.6 pIC50 = 8.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
49865951 16199 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 463 4 1 4 5.7 Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224189 16199 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 463 4 1 4 5.7 Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
10072252 72618 0 None 17 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72618 0 None 17 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10434371 72957 0 None 5 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72957 0 None 5 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
11719164 140269 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL380568 140269 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453637 97989 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL272758 97989 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
6918497 113430 2 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 113430 2 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 113430 2 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
44453229 95399 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 426 7 2 4 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL256889 95399 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 426 7 2 4 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1016/j.bmcl.2007.09.068
58138845 176123 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 429 4 1 3 5.6 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4591935 176123 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 429 4 1 3 5.6 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.12.024
155562877 175226 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4571547 175226 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
25254218 16185 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224120 16185 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
24782826 189586 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL514611 189586 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.07.082
25233755 179337 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 457 4 1 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F 10.1021/jm801416q
CHEMBL473532 179337 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 457 4 1 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F 10.1021/jm801416q
24782826 189586 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1021/jm801416q
CHEMBL514611 189586 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1021/jm801416q
58138826 170402 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4448064 170402 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44309195 102148 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 496 9 3 5 3.6 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 10.1016/j.bmcl.2004.02.022
CHEMBL302533 102148 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 496 9 3 5 3.6 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 10.1016/j.bmcl.2004.02.022
44453167 95736 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258363 95736 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
44453195 155176 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 496 4 1 4 4.8 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL402327 155176 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 496 4 1 4 4.8 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453197 155413 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL403665 155413 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
44430748 87221 0 None 72 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232837 87221 0 None 72 2 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453504 95527 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 10.1016/j.bmcl.2007.09.068
CHEMBL257452 95527 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 10.1016/j.bmcl.2007.09.068
10003548 71972 0 None -223 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71972 0 None -223 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
52916803 170982 18 None - 1 Human 7.6 pIC50 = 7.6 Functional
Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.6019/CHEMBL5209897
CHEMBL4456123 170982 18 None - 1 Human 7.6 pIC50 = 7.6 Functional
Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.6019/CHEMBL5209897
46858281 171408 3 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 394 4 1 4 4.2 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4462565 171408 3 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 394 4 1 4 4.2 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44453433 160839 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL411476 160839 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2007.09.068
44430723 86841 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232253 86841 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44469380 170246 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F 10.1016/j.bmcl.2018.12.024
CHEMBL4445779 170246 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F 10.1016/j.bmcl.2018.12.024
9889700 118588 17 None 11 4 Human 5.6 pIC50 = 5.6 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL34166 118588 17 None 11 4 Human 5.6 pIC50 = 5.6 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
44453464 95301 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256449 95301 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
58138911 174614 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 463 4 1 3 6.3 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4557554 174614 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 463 4 1 3 6.3 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.12.024
76336764 106187 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 766 12 4 4 12.8 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138187 106187 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 766 12 4 4 12.8 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138134 211120 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138376 211120 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
44453157 155267 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL402827 155267 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
155538947 172784 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 4 1 3 5.5 Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4513370 172784 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 4 1 3 5.5 Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44405203 72486 0 None 31 2 Human 7.6 pIC50 = 7.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72486 0 None 31 2 Human 7.6 pIC50 = 7.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44453161 95269 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL256271 95269 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
44453435 97601 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL270863 97601 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2007.09.068
44537841 675 13 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
57889181 675 13 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
9497 675 13 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL2398716 675 13 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL3334824 675 13 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
45138007 170453 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4448761 170453 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
71462570 82566 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assayAntagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assay
ChEMBL 518 5 2 5 5.6 CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O 10.1021/jm300682j
CHEMBL2178569 82566 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assayAntagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assay
ChEMBL 518 5 2 5 5.6 CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O 10.1021/jm300682j
44453403 95136 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL255629 95136 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl 10.1016/j.bmcl.2007.09.068
44453202 95293 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256404 95293 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
11743399 72483 12 None 32 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72483 12 None 32 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10072252 72618 0 None 17 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72618 0 None 17 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
11554849 72852 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72852 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44405211 133593 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
CHEMBL371248 133593 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
9980155 71816 0 None -23 2 Mouse 6.5 pIC50 = 6.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71816 0 None -23 2 Mouse 6.5 pIC50 = 6.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
10072252 72618 0 None 17 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72618 0 None 17 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405202 72994 0 None -17 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72994 0 None -17 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
44405181 132824 0 None -51 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132824 0 None -51 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
9804868 33838 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 5 1 4 6.0 N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 10.1021/jm990316l
CHEMBL142318 33838 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 5 1 4 6.0 N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 10.1021/jm990316l
44309122 102820 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 482 11 4 6 3.4 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO 10.1016/j.bmcl.2004.02.022
CHEMBL305423 102820 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 482 11 4 6 3.4 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO 10.1016/j.bmcl.2004.02.022
1370410 86902 11 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 404 3 0 4 3.4 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2013.01.005
CHEMBL2322888 86902 11 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 404 3 0 4 3.4 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2013.01.005
11743399 72483 12 None 32 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72483 12 None 32 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10811393 34886 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 407 7 1 4 4.8 N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm990316l
CHEMBL143194 34886 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 407 7 1 4 4.8 N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm990316l
44453227 95397 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256887 95397 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10649043 34554 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 499 5 1 4 5.5 CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 10.1021/jm990316l
CHEMBL142925 34554 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 499 5 1 4 5.5 CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 10.1021/jm990316l
45138010 170859 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
CHEMBL4454067 170859 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
25233754 179336 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl 10.1021/jm801416q
CHEMBL473531 179336 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl 10.1021/jm801416q
44453469 95733 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL258360 95733 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2007.09.068
155526212 171037 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 406 4 1 2 5.7 Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4456839 171037 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 406 4 1 2 5.7 Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44453437 160840 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL411477 160840 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2007.09.068
44405180 140633 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 431 6 1 3 4.1 CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL381446 140633 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 431 6 1 3 4.1 CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44453165 95735 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258362 95735 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
44453263 155641 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL404732 155641 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2007.09.068
44430755 153425 0 None 42 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL397910 153425 0 None 42 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453528 97540 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 10.1016/j.bmcl.2007.09.068
CHEMBL270564 97540 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 10.1016/j.bmcl.2007.09.068
44430753 142023 0 None 77 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387608 142023 0 None 77 2 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
25252974 16198 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224188 16198 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
17753030 87011 0 None 39 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232441 87011 0 None 39 2 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
10434371 72957 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72957 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44405176 135405 0 None -1 2 Mouse 8.4 pIC50 = 8.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL372807 135405 0 None -1 2 Mouse 8.4 pIC50 = 8.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
58138789 172311 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4475237 172311 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
21070989 86889 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86889 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
44453291 97423 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL269957 97423 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
44453361 167323 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 456 7 2 4 4.0 Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL429419 167323 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 456 7 2 4 4.0 Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
512282 758 59 None 141 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 758 59 None 141 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 758 59 None 141 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
11554849 72852 0 None -2 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72852 0 None -2 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
9980155 71816 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71816 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
9845614 121282 26 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 430 6 1 3 5.5 N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL357919 121282 26 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 430 6 1 3 5.5 N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL3138115 211122 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138540 211122 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
59278474 172132 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 6 1 7 2.8 O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4472994 172132 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 6 1 7 2.8 O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
11554849 72852 0 None 2 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72852 0 None 2 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453321 97490 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270254 97490 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
155561040 175373 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 418 6 2 5 2.7 CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4574870 175373 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 418 6 2 5 2.7 CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1 10.1016/j.bmcl.2018.11.015
44453290 97422 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL269956 97422 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
59278286 171555 1 None -112 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 171555 1 None -112 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
44469942 174946 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4565496 174946 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
25233582 190102 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 401 5 1 3 4.0 COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 10.1021/jm801416q
CHEMBL517290 190102 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 401 5 1 3 4.0 COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 10.1021/jm801416q
44309245 203444 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 556 13 3 5 5.2 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 10.1016/j.bmcl.2004.02.022
CHEMBL65784 203444 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 556 13 3 5 5.2 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 10.1016/j.bmcl.2004.02.022
10001921 72453 0 None -3 2 Mouse 6.4 pIC50 = 6.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72453 0 None -3 2 Mouse 6.4 pIC50 = 6.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
9980155 71816 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71816 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
45138012 170209 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4445316 170209 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
58138781 175102 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 379 4 1 3 4.7 O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4568987 175102 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 379 4 1 3 4.7 O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44453198 95617 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 516 4 1 4 5.2 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL257853 95617 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 516 4 1 4 5.2 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
44430746 87117 0 None 41 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232638 87117 0 None 41 2 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44480348 175778 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1ccc(S(C)(=O)=O)nc1 10.1016/j.bmcl.2018.11.015
CHEMBL4583870 175778 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1ccc(S(C)(=O)=O)nc1 10.1016/j.bmcl.2018.11.015
44453639 158864 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL409498 158864 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44405203 72486 0 None -31 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72486 0 None -31 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
10503785 121119 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 451 7 1 4 5.3 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 10.1021/jm990316l
CHEMBL357434 121119 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 451 7 1 4 5.3 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 10.1021/jm990316l
59687824 82569 1 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 469 5 1 5 3.6 CO[C@@H]1COCC[C@@H]1NC1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1 10.1021/jm300682j
CHEMBL2178572 82569 1 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 469 5 1 5 3.6 CO[C@@H]1COCC[C@@H]1NC1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1 10.1021/jm300682j
44430753 142023 0 None 77 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387608 142023 0 None 77 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44470083 171578 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4465000 171578 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
44309312 203778 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 460 9 3 5 3.4 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 10.1016/j.bmcl.2004.02.022
CHEMBL68145 203778 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 460 9 3 5 3.4 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 10.1016/j.bmcl.2004.02.022
21070989 86889 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86889 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
44453200 95668 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2007.09.068
CHEMBL258065 95668 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2007.09.068
44405181 132824 0 None 51 2 Human 7.3 pIC50 = 7.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132824 0 None 51 2 Human 7.3 pIC50 = 7.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10434371 72957 0 None -5 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72957 0 None -5 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44405212 72968 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72968 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
155549724 173861 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4539264 173861 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.11.015
10388824 133438 0 None -4 2 Mouse 6.3 pIC50 = 6.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 133438 0 None -4 2 Mouse 6.3 pIC50 = 6.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
9870185 84096 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2207666 84096 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
162658125 181096 0 None -125 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 10.1021/acs.jmedchem.0c01137
CHEMBL4760108 181096 0 None -125 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 10.1021/acs.jmedchem.0c01137
162666730 182274 1 None -707 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 589 9 2 6 6.5 N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.0c01137
CHEMBL4783861 182274 1 None -707 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 589 9 2 6 6.5 N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.0c01137
44453436 97647 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
CHEMBL271079 97647 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
44453293 167404 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
CHEMBL429591 167404 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
9869274 119313 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 468 5 1 3 6.4 N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 10.1021/jm990316l
CHEMBL344073 119313 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 468 5 1 3 6.4 N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 10.1021/jm990316l
44430745 142051 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387822 142051 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
10111333 175467 0 None -19 2 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4577133 175467 0 None -19 2 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
58138841 169636 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4437170 169636 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5<