Ligand source activities (1 row/activity)



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Ligands Receptor Assay information Chemical information
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name		 GPCRdb ID #Vendors Reference
ligand		 Fold selectivity
(Potency)		 # tested GPCRs
(Potency)		 Species p-value
(-log)		 Type Activity
Relation		 Activity
Value		 Assay Type Assay Description Source Mol
weight		 Rot
Bonds		 H don H acc LogP Smiles DOI
93149 106704 78 None -1 3 Human 6.0 pEC50 = 6 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
CHEMBL316589 106704 78 None -1 3 Human 6.0 pEC50 = 6 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12 10.1021/jm301121j
336912 83356 26 None - 1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1 10.1021/jm301121j
CHEMBL2205802 83356 26 None - 1 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1 10.1021/jm301121j
2733927 83361 90 None -1 3 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
CHEMBL2205808 83361 90 None -1 3 Human 5.0 pEC50 = 5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1 10.1021/jm301121j
667748 83358 78 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
CHEMBL2205805 83358 78 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
20445 83359 105 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
CHEMBL2205806 83359 105 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
667748 83358 78 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
CHEMBL2205805 83358 78 None -3 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1 10.1021/jm301121j
15783796 83364 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83364 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
602123 83357 50 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
CHEMBL2205803 83357 50 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
20445 83359 105 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
CHEMBL2205806 83359 105 None -2 2 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1 10.1021/jm301121j
15783796 83364 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
CHEMBL2205810 83364 1 None -1 3 Human 5.9 pEC50 = 5.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1 10.1021/jm301121j
602123 83357 50 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
CHEMBL2205803 83357 50 None - 1 Human 4.9 pEC50 = 4.9 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1 10.1021/jm301121j
74265 206596 107 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 206596 107 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
353741 71705 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
CHEMBL1976682 71705 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
65237 137086 97 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 137086 97 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
74265 206596 107 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
CHEMBL99384 206596 107 None -3 3 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C 10.1021/jm301121j
353741 71705 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
CHEMBL1976682 71705 7 None - 1 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1 10.1021/jm301121j
15664 83360 93 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83360 93 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
65237 137086 97 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
CHEMBL375781 137086 97 None 28 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1 10.1021/jm301121j
15664 83360 93 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
CHEMBL2205807 83360 93 None -3 3 Human 4.8 pEC50 = 4.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1 10.1021/jm301121j
72791 206489 71 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL98682 206489 71 None 1 2 Human 5.8 pEC50 = 5.8 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
77865 106789 76 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL317115 106789 76 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
72791 206489 71 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL98682 206489 71 None 1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12 10.1021/jm301121j
12041800 201790 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
ChEMBL 410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 10.1016/j.bmcl.2011.11.014
CHEMBL66165 201790 0 None - 1 Human 5.7 pEC50 = 5.7 Functional
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
ChEMBL 410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1 10.1016/j.bmcl.2011.11.014
77865 106789 76 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
CHEMBL317115 106789 76 None -1 2 Human 5.7 pEC50 = 5.7 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12 10.1021/jm301121j
1474 153853 133 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 153853 133 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
1474 153853 133 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
CHEMBL39879 153853 133 None 1 3 Human 4.5 pEC50 = 4.5 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1 10.1021/jm301121j
14338 4287 115 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4287 115 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
14338 4287 115 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
CHEMBL101165 4287 115 None -3 3 Human 5.4 pEC50 = 5.4 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1 10.1021/jm301121j
12987698 83362 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83362 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
14434082 83355 11 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83355 11 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
14434082 83355 11 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
CHEMBL2205801 83355 11 None 1 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12 10.1021/jm301121j
12987698 83362 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
CHEMBL2205809 83362 4 None -2 3 Human 5.3 pEC50 = 5.3 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1 10.1021/jm301121j
12425 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
1318 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
CHEMBL415879 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
DB02365 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
12425 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
1318 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
CHEMBL415879 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
DB02365 6 116 None -5 4 Human 5.2 pEC50 = 5.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 180 0 0 2 2.8 C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1 10.1021/jm301121j
70848 204935 105 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 204935 105 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
70848 204935 105 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
CHEMBL89445 204935 105 None -12 3 Human 4.2 pEC50 = 4.2 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1 10.1021/jm301121j
72792 198031 76 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 198031 76 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
72792 198031 76 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
CHEMBL593442 198031 76 None -7 3 Human 6.1 pEC50 = 6.1 Functional
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
ChEMBL 208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12 10.1021/jm301121j
11151928 188887 0 None -1 4 Human 9.8 pED50 = 9.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assay
ChEMBL 338 11 2 2 4.3 CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O 10.1021/jm900133w
CHEMBL513863 188887 0 None -1 4 Human 9.8 pED50 = 9.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 2 hrs by microtiter format trans-well migration assay
ChEMBL 338 11 2 2 4.3 CCCCCCCCCCC(C)(C)C(=O)N[C@H]1CCCCNC1=O 10.1021/jm900133w
10456104 71623 0 None 56 2 Human 10.0 pIC50 = 10 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71623 0 None 56 2 Human 10.0 pIC50 = 10 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
59278332 170495 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4457209 170495 0 None - 1 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
59278286 170979 1 None 112 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 170979 1 None 112 2 Human 9.7 pIC50 = 9.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
45138759 171761 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4475581 171761 0 None - 1 Human 9.5 pIC50 = 9.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
512282 745 55 None 9 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 745 55 None 9 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 745 55 None 9 3 Human 9.4 pIC50 = 9.4 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
6918497 112918 1 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 112918 1 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 112918 1 None -1 4 Human 9.1 pIC50 = 9.1 Functional
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
66686405 174657 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
CHEMBL4571977 174657 0 None - 1 Human 9.1 pIC50 = 9.1 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2 10.1016/j.bmcl.2018.11.015
9980155 71457 0 None 23 2 Human 9.1 pIC50 = 9.1 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71457 0 None 23 2 Human 9.1 pIC50 = 9.1 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
10003548 71613 0 None 223 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71613 0 None 223 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
11743399 72123 12 None 32 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72123 12 None 32 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405176 134869 0 None 1 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL372807 134869 0 None 1 2 Human 9.0 pIC50 = 9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44309143 201788 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN 10.1016/j.bmcl.2004.02.022
CHEMBL66159 201788 0 None - 1 Human 9.0 pIC50 = 9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN 10.1016/j.bmcl.2004.02.022
59278147 172415 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4518015 172415 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1 10.1016/j.bmcl.2018.12.024
512282 745 55 None 9 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
767 745 55 None 9 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
CHEMBL232656 745 55 None 9 3 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2018.11.015
59278115 174253 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4562738 174253 0 None - 1 Human 8.9 pIC50 = 8.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
512282 745 55 None 9 3 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
767 745 55 None 9 3 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
CHEMBL232656 745 55 None 9 3 Human 8.8 pIC50 = 8.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1021/jm801416q
10434371 72596 0 None 5 2 Human 8.8 pIC50 = 8.8 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72596 0 None 5 2 Human 8.8 pIC50 = 8.8 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
52916803 170405 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4456123 170405 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 10.1016/j.bmcl.2018.12.024
155511620 169008 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
CHEMBL4436061 169008 0 None - 1 Human 8.0 pIC50 = 8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
11554849 72492 0 None 2 2 Human 8.0 pIC50 = 8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72492 0 None 2 2 Human 8.0 pIC50 = 8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453265 94929 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL256821 94929 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1 10.1016/j.bmcl.2007.09.068
44453400 95076 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL257509 95076 0 None - 1 Human 7.0 pIC50 = 7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl 10.1016/j.bmcl.2007.09.068
10003548 71613 0 None 223 2 Human 7.0 pIC50 = 7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71613 0 None 223 2 Human 7.0 pIC50 = 7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
10072252 72258 0 None -17 2 Mouse 6.0 pIC50 = 6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72258 0 None -17 2 Mouse 6.0 pIC50 = 6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405203 72126 0 None 31 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72126 0 None 31 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44405202 72633 0 None 17 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72633 0 None 17 2 Human 6.0 pIC50 = 6 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
76322249 105686 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3137848 105686 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138130 209363 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138370 209363 0 None - 1 Human 5.0 pIC50 = 5 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
44453225 95281 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL258368 95281 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10003548 71613 0 None 223 2 Human 5.0 pIC50 = 5.0 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71613 0 None 223 2 Human 5.0 pIC50 = 5.0 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
10789018 34935 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm990316l
CHEMBL143499 34935 0 None - 1 Human 5.0 pIC50 = 5.0 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1 10.1021/jm990316l
44453503 94623 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 10.1016/j.bmcl.2007.09.068
CHEMBL255338 94623 0 None - 1 Human 7.0 pIC50 = 7.0 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1 10.1016/j.bmcl.2007.09.068
58138765 173833 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4552741 173833 0 None - 1 Human 6.0 pIC50 = 6.0 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1 10.1016/j.bmcl.2018.12.024
44309194 201836 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL66457 201836 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
44430752 87555 0 None 7 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87555 0 None 7 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44430752 87555 0 None 7 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL234295 87555 0 None 7 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
59278305 169454 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4442765 169454 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
59278307 170975 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464575 170975 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
44470374 175293 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 10.1016/j.bmcl.2018.12.024
CHEMBL4586189 175293 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1 10.1016/j.bmcl.2018.12.024
44453162 94813 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
CHEMBL256272 94813 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
44453199 95210 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258064 95210 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1 10.1016/j.bmcl.2007.09.068
44469804 171442 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
CHEMBL4471579 171442 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
44405203 72126 0 None 31 2 Human 6.9 pIC50 = 6.9 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72126 0 None 31 2 Human 6.9 pIC50 = 6.9 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44309407 102478 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 10.1016/j.bmcl.2004.02.022
CHEMBL306457 102478 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1 10.1016/j.bmcl.2004.02.022
44468442 169974 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4450029 169974 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
155530458 170963 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2018.11.015
CHEMBL4464403 170963 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO 10.1016/j.bmcl.2018.11.015
44468440 172776 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4527255 172776 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44453357 97061 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270419 97061 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453525 97041 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270358 97041 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44309161 202335 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 10.1016/j.bmcl.2004.02.022
CHEMBL69876 202335 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1 10.1016/j.bmcl.2004.02.022
CHEMBL3138123 209361 0 None - 1 Human 4.9 pIC50 = 4.9 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CSCC[C@H](NC(=O)c1cc(C(=CCC[C@H]2CC[C@@]3(C)C(CC[C@@H]4[C@@H]3CC[C@@]3(C)[C@H]4CC[C@@H]3C(C)CCCC(C)C)C2)c2cc(Cl)c(O)c(C(=O)N[C@@H](CCSC)C(=O)O)c2)cc(Cl)c1O)C(=O)O 10.1016/s0960-894x(00)00601-6
44453638 165918 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL427834 165918 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44430746 86675 0 None -1 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232638 86675 0 None -1 3 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
155564974 174894 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
CHEMBL4577357 174894 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F 10.1016/j.bmcl.2018.11.015
10388824 132904 0 None 4 2 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 132904 0 None 4 2 Human 7.9 pIC50 = 7.9 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44309397 202103 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL68366 202103 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
44453320 97027 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270253 97027 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453579 155036 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404465 155036 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44309364 202213 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.022
CHEMBL69123 202213 0 None - 1 Human 6.9 pIC50 = 6.9 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1 10.1016/j.bmcl.2004.02.022
44453615 94708 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL255797 94708 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44453402 95116 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL257698 95116 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1 10.1016/j.bmcl.2007.09.068
10456104 71623 0 None 56 2 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71623 0 None 56 2 Human 5.9 pIC50 = 5.9 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44430723 86399 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232253 86399 0 None - 1 Human 7.9 pIC50 = 7.9 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453614 154714 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL402825 154714 0 None - 1 Human 5.9 pIC50 = 5.9 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
24758044 82436 0 None 14 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
ChEMBL 398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
CHEMBL2180528 82436 0 None 14 2 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
ChEMBL 398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1 10.1021/jm300896d
44480600 174479 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4568048 174479 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.11.015
44405212 72607 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72607 0 None 1 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
10001921 72093 0 None 3 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72093 0 None 3 2 Human 6.8 pIC50 = 6.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
512282 745 55 None -147 3 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 745 55 None -147 3 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 745 55 None -147 3 Mouse 5.8 pIC50 = 5.8 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
10388824 132904 0 None 4 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 132904 0 None 4 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
49865900 15992 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224118 15992 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
24782574 178772 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
CHEMBL473734 178772 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
9980155 71457 0 None 23 2 Human 7.8 pIC50 = 7.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71457 0 None 23 2 Human 7.8 pIC50 = 7.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
44405234 132756 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370447 132756 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10575889 33453 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL142199 33453 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
44453084 94811 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 6 2 3 4.6 O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
CHEMBL256264 94811 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 6 2 3 4.6 O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
44430713 86275 0 None 2 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL231829 86275 0 None 2 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
58138868 169970 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1 10.1016/j.bmcl.2018.12.024
CHEMBL4449996 169970 0 None - 1 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1 10.1016/j.bmcl.2018.12.024
58138852 173483 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 7 2 5 3.4 CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4544186 173483 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 7 2 5 3.4 CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
58138832 169298 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.9 COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4440452 169298 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.9 COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
155544726 174358 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4565390 174358 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44405194 71474 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 427 5 1 3 3.9 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
CHEMBL196908 71474 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 427 5 1 3 3.9 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
44405181 132290 0 None 51 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132290 0 None 51 2 Human 5.8 pIC50 = 5.8 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
512282 745 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
767 745 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
CHEMBL232656 745 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
512282 745 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
767 745 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
CHEMBL232656 745 55 None 9 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2007.03.104
44430713 86275 0 None 2 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL231829 86275 0 None 2 3 Human 7.8 pIC50 = 7.8 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453467 95275 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL258359 95275 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453363 97064 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 10.1016/j.bmcl.2007.09.068
CHEMBL270433 97064 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12 10.1016/j.bmcl.2007.09.068
44453501 97344 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL271903 97344 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 512 4 1 4 4.2 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453292 154929 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 448 4 1 4 3.8 Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404033 154929 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 448 4 1 4 3.8 Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
58138893 174903 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4577460 174903 0 None - 1 Human 6.8 pIC50 = 6.8 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
11801020 12127 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
CHEMBL1184558 12127 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
CHEMBL356099 12127 0 None - 1 Human 5.8 pIC50 = 5.8 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
22725647 173117 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4535696 173117 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
44430745 141507 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387822 141507 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
45138458 171112 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 1 7 2.7 CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4466500 171112 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 1 7 2.7 CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
44453164 95277 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F 10.1016/j.bmcl.2007.09.068
CHEMBL258361 95277 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F 10.1016/j.bmcl.2007.09.068
10001921 72093 0 None 3 2 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72093 0 None 3 2 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
155533145 171245 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 4 1 2 6.3 Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4468514 171245 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 409 4 1 2 6.3 Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1 10.1016/j.bmcl.2018.11.015
10766998 33786 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 476 7 1 4 5.5 COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br 10.1021/jm990316l
CHEMBL142468 33786 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 476 7 1 4 5.5 COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br 10.1021/jm990316l
22725647 173117 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4535696 173117 0 None -52 2 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
10164 859 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
135565361 859 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
CHEMBL4444976 859 14 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 4 1 8 2.2 COc1cc(ccc1Cl)N1CCN(CC1)C(=O)Cn1[nH]c(=C2N=CC=N2)c2c1nccc2 10.1016/j.bmcl.2018.11.015
52917500 171692 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 465 5 1 7 3.2 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4474606 171692 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 465 5 1 7 3.2 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1 10.1016/j.bmcl.2018.12.024
59278436 171730 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 2 6 2.4 CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4475173 171730 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 439 6 2 6 2.4 CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
10049340 102157 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 448 11 3 5 3.3 CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
CHEMBL304358 102157 0 None - 1 Human 8.7 pIC50 = 8.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 448 11 3 5 3.3 CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O 10.1016/j.bmcl.2004.02.022
512282 745 55 None 9 3 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 745 55 None 9 3 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 745 55 None 9 3 Human 8.6 pIC50 = 8.6 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
44405181 132290 0 None 51 2 Human 8.6 pIC50 = 8.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132290 0 None 51 2 Human 8.6 pIC50 = 8.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
49865951 16008 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 463 4 1 4 5.7 Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224189 16008 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 463 4 1 4 5.7 Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
10072252 72258 0 None 17 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72258 0 None 17 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10434371 72596 0 None 5 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72596 0 None 5 2 Human 7.7 pIC50 = 7.7 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
11719164 139726 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL380568 139726 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453637 97527 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL272758 97527 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
6918497 112918 1 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL277930 112918 1 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
CHEMBL331897 112918 1 None -17 4 Mouse 7.7 pIC50 = 7.7 Functional
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
ChEMBL 527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1 10.1021/jm0004244
44453229 94942 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 426 7 2 4 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL256889 94942 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 426 7 2 4 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1 10.1016/j.bmcl.2007.09.068
58138845 175539 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 429 4 1 3 5.6 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4591935 175539 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 429 4 1 3 5.6 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.12.024
155562877 174644 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4571547 174644 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 403 5 1 5 3.2 Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
25254218 15994 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224120 15994 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
24782826 188985 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL514611 188985 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2010.07.082
25233755 178747 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 457 4 1 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F 10.1021/jm801416q
CHEMBL473532 178747 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 457 4 1 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F 10.1021/jm801416q
24782826 188985 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1021/jm801416q
CHEMBL514611 188985 8 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1 10.1021/jm801416q
58138826 169823 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4448064 169823 0 None - 1 Human 7.7 pIC50 = 7.7 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44309195 101665 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 496 9 3 5 3.6 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 10.1016/j.bmcl.2004.02.022
CHEMBL302533 101665 0 None - 1 Human 6.7 pIC50 = 6.7 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 496 9 3 5 3.6 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1 10.1016/j.bmcl.2004.02.022
44453167 95279 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258363 95279 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
44453195 154625 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 496 4 1 4 4.8 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL402327 154625 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 496 4 1 4 4.8 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
44453197 154862 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL403665 154862 0 None - 1 Human 5.7 pIC50 = 5.7 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
44430748 86779 0 None 1 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232837 86779 0 None 1 3 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453504 95070 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 10.1016/j.bmcl.2007.09.068
CHEMBL257452 95070 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1 10.1016/j.bmcl.2007.09.068
10003548 71613 0 None -223 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197345 71613 0 None -223 2 Mouse 4.6 pIC50 = 4.6 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C 10.1016/j.bmcl.2005.08.057
52916803 170405 14 None - 1 Human 7.6 pIC50 = 7.6 Functional
Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 nan
CHEMBL4456123 170405 14 None - 1 Human 7.6 pIC50 = 7.6 Functional
Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1
ChEMBL 451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1 nan
46858281 170832 3 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 394 4 1 4 4.2 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4462565 170832 3 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 394 4 1 4 4.2 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44453433 160280 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2007.09.068
CHEMBL411476 160280 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2007.09.068
44430723 86399 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232253 86399 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44469380 169668 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F 10.1016/j.bmcl.2018.12.024
CHEMBL4445779 169668 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F 10.1016/j.bmcl.2018.12.024
9889700 118070 13 None 11 4 Human 5.6 pIC50 = 5.6 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL34166 118070 13 None 11 4 Human 5.6 pIC50 = 5.6 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
44453464 94844 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256449 94844 0 None - 1 Human 5.6 pIC50 = 5.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
58138911 174032 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 463 4 1 3 6.3 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4557554 174032 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 463 4 1 3 6.3 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.12.024
76336764 105693 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 766 12 4 4 12.8 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138187 105693 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL 766 12 4 4 12.8 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138134 209364 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138376 209364 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
44453157 154716 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL402827 154716 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
155538947 172205 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 4 1 3 5.5 Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4513370 172205 0 None - 1 Human 7.6 pIC50 = 7.6 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 4 1 3 5.5 Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44405203 72126 0 None 31 2 Human 7.6 pIC50 = 7.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72126 0 None 31 2 Human 7.6 pIC50 = 7.6 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
44453161 94812 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL256271 94812 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.5 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
44453435 97139 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL270863 97139 0 None - 1 Human 6.6 pIC50 = 6.6 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl 10.1016/j.bmcl.2007.09.068
44537841 667 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
57889181 667 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
9497 667 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL2398716 667 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL3334824 667 8 None 114 2 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C 10.1016/j.bmcl.2018.11.015
45138007 169875 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4448761 169875 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
71462570 82140 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assayAntagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assay
ChEMBL 518 5 2 5 5.6 CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O 10.1021/jm300682j
CHEMBL2178569 82140 0 None - 1 Human 8.5 pIC50 = 8.5 Functional
Antagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assayAntagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assay
ChEMBL 518 5 2 5 5.6 CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O 10.1021/jm300682j
44453403 94680 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL255629 94680 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl 10.1016/j.bmcl.2007.09.068
44453202 94836 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256404 94836 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
11743399 72123 12 None 32 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72123 12 None 32 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10072252 72258 0 None 17 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72258 0 None 17 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
11554849 72492 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72492 0 None 2 2 Human 7.5 pIC50 = 7.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44405211 133057 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
CHEMBL371248 133057 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1 10.1016/j.bmcl.2005.08.057
9980155 71457 0 None -23 2 Mouse 6.5 pIC50 = 6.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71457 0 None -23 2 Mouse 6.5 pIC50 = 6.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
10072252 72258 0 None 17 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL199412 72258 0 None 17 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44405202 72633 0 None -17 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72633 0 None -17 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
44405181 132290 0 None -51 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132290 0 None -51 2 Mouse 5.5 pIC50 = 5.5 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
9804868 33601 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 5 1 4 6.0 N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 10.1021/jm990316l
CHEMBL142318 33601 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 5 1 4 6.0 N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21 10.1021/jm990316l
44309122 102334 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 482 11 4 6 3.4 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO 10.1016/j.bmcl.2004.02.022
CHEMBL305423 102334 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 482 11 4 6 3.4 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO 10.1016/j.bmcl.2004.02.022
1370410 86460 11 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 404 3 0 4 3.4 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2013.01.005
CHEMBL2322888 86460 11 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 404 3 0 4 3.4 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1 10.1016/j.bmcl.2013.01.005
11743399 72123 12 None 32 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72123 12 None 32 2 Human 6.5 pIC50 = 6.5 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10811393 34647 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 407 7 1 4 4.8 N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm990316l
CHEMBL143194 34647 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 407 7 1 4 4.8 N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1 10.1021/jm990316l
44453227 94940 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL256887 94940 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10649043 34316 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 499 5 1 4 5.5 CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 10.1021/jm990316l
CHEMBL142925 34316 0 None - 1 Human 5.5 pIC50 = 5.5 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 499 5 1 4 5.5 CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21 10.1021/jm990316l
45138010 170282 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
CHEMBL4454067 170282 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1 10.1016/j.bmcl.2018.12.024
25233754 178746 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl 10.1021/jm801416q
CHEMBL473531 178746 0 None - 1 Human 7.5 pIC50 = 7.5 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl 10.1021/jm801416q
44453469 95276 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL258360 95276 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl 10.1016/j.bmcl.2007.09.068
155526212 170460 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 406 4 1 2 5.7 Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4456839 170460 0 None - 1 Human 6.5 pIC50 = 6.5 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 406 4 1 2 5.7 Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
44453437 160281 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL411477 160281 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl 10.1016/j.bmcl.2007.09.068
44405180 140089 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 431 6 1 3 4.1 CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL381446 140089 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 431 6 1 3 4.1 CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
44453165 95278 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL258362 95278 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1 10.1016/j.bmcl.2007.09.068
44453263 155089 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2007.09.068
CHEMBL404732 155089 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1 10.1016/j.bmcl.2007.09.068
44430755 152879 0 None 5 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL397910 152879 0 None 5 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44453528 97078 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 10.1016/j.bmcl.2007.09.068
CHEMBL270564 97078 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1 10.1016/j.bmcl.2007.09.068
44430753 141479 0 None 1 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387608 141479 0 None 1 3 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
25252974 16007 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224188 16007 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
17753030 86569 0 None 3 3 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232441 86569 0 None 3 3 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
10434371 72596 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72596 0 None 5 2 Human 8.4 pIC50 = 8.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44405176 134869 0 None -1 2 Mouse 8.4 pIC50 = 8.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL372807 134869 0 None -1 2 Mouse 8.4 pIC50 = 8.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
58138789 171735 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4475237 171735 0 None - 1 Human 8.4 pIC50 = 8.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
21070989 86447 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86447 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
44453291 96960 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
CHEMBL269957 96960 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl 10.1016/j.bmcl.2007.09.068
44453361 166758 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 456 7 2 4 4.0 Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL429419 166758 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 456 7 2 4 4.0 Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1016/j.bmcl.2007.09.068
512282 745 55 None 9 3 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 745 55 None 9 3 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 745 55 None 9 3 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
11554849 72492 0 None -2 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72492 0 None -2 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
9980155 71457 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71457 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
9845614 120756 22 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 430 6 1 3 5.5 N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL357919 120756 22 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 430 6 1 3 5.5 N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL3138115 209366 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138540 209366 0 None - 1 Human 5.4 pIC50 = 5.4 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
59278474 171556 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 6 1 7 2.8 O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4472994 171556 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 451 6 1 7 2.8 O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
11554849 72492 0 None 2 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200242 72492 0 None 2 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
44453321 97028 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL270254 97028 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 502 4 1 4 4.8 O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
155561040 174791 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 418 6 2 5 2.7 CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4574870 174791 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 418 6 2 5 2.7 CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1 10.1016/j.bmcl.2018.11.015
44453290 96959 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL269956 96959 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1 10.1016/j.bmcl.2007.09.068
59278286 170979 1 None -112 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4464625 170979 1 None -112 2 Mouse 7.4 pIC50 = 7.4 Functional
Antagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1 10.1016/j.bmcl.2018.12.024
44469942 174364 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4565496 174364 0 None - 1 Human 7.4 pIC50 = 7.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
25233582 189499 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 401 5 1 3 4.0 COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 10.1021/jm801416q
CHEMBL517290 189499 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 401 5 1 3 4.0 COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1 10.1021/jm801416q
44309245 201743 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 556 13 3 5 5.2 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 10.1016/j.bmcl.2004.02.022
CHEMBL65784 201743 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 556 13 3 5 5.2 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1 10.1016/j.bmcl.2004.02.022
10001921 72093 0 None -3 2 Mouse 6.4 pIC50 = 6.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72093 0 None -3 2 Mouse 6.4 pIC50 = 6.4 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
9980155 71457 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
CHEMBL196860 71457 0 None 23 2 Human 7.4 pIC50 = 7.4 Functional
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
ChEMBL 430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O 10.1016/j.bmcl.2005.08.057
45138012 169631 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4445316 169631 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
58138781 174520 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 379 4 1 3 4.7 O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4568987 174520 0 None - 1 Human 6.4 pIC50 = 6.4 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 379 4 1 3 4.7 O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1 10.1016/j.bmcl.2018.12.024
44453198 95160 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 516 4 1 4 5.2 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL257853 95160 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 516 4 1 4 5.2 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1 10.1016/j.bmcl.2007.09.068
44430746 86675 0 None -1 3 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232638 86675 0 None -1 3 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44480348 175195 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1ccc(S(C)(=O)=O)nc1 10.1016/j.bmcl.2018.11.015
CHEMBL4583870 175195 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1ccc(S(C)(=O)=O)nc1 10.1016/j.bmcl.2018.11.015
44453639 158306 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
CHEMBL409498 158306 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1 10.1016/j.bmcl.2007.09.068
44405203 72126 0 None -31 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
CHEMBL198966 72126 0 None -31 2 Mouse 5.3 pIC50 = 5.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12 10.1016/j.bmcl.2005.08.057
10503785 120593 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 451 7 1 4 5.3 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 10.1021/jm990316l
CHEMBL357434 120593 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 451 7 1 4 5.3 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)N1CCCCC1 10.1021/jm990316l
59687824 82143 1 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 469 5 1 5 3.6 CO[C@@H]1COCC[C@@H]1NC1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1 10.1021/jm300682j
CHEMBL2178572 82143 1 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 469 5 1 5 3.6 CO[C@@H]1COCC[C@@H]1NC1CC[C@@](C(=O)N2CCc3ncc(C(F)(F)F)cc3C2)(C(C)C)C1 10.1021/jm300682j
44430753 141479 0 None 1 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387608 141479 0 None 1 3 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44470083 171002 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4465000 171002 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 466 7 2 5 3.8 CC(C)NS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
44309312 202073 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 460 9 3 5 3.4 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 10.1016/j.bmcl.2004.02.022
CHEMBL68145 202073 0 None - 1 Human 8.3 pIC50 = 8.3 Functional
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
ChEMBL 460 9 3 5 3.4 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCCC1 10.1016/j.bmcl.2004.02.022
21070989 86447 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
CHEMBL2322875 86447 0 None 354 2 Human 8.3 pIC50 = 8.3 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
ChEMBL 450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl 10.1016/j.bmcl.2013.01.005
44453200 95211 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2007.09.068
CHEMBL258065 95211 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F 10.1016/j.bmcl.2007.09.068
44405181 132290 0 None 51 2 Human 7.3 pIC50 = 7.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370162 132290 0 None 51 2 Human 7.3 pIC50 = 7.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10434371 72596 0 None -5 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
CHEMBL200629 72596 0 None -5 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl 10.1016/j.bmcl.2005.08.057
44405212 72607 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72607 0 None -1 2 Mouse 7.3 pIC50 = 7.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
155549724 173279 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.11.015
CHEMBL4539264 173279 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1 10.1016/j.bmcl.2018.11.015
10388824 132904 0 None -4 2 Mouse 6.3 pIC50 = 6.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL370596 132904 0 None -4 2 Mouse 6.3 pIC50 = 6.3 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
9870185 83668 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
CHEMBL2207666 83668 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at CCR1Antagonist activity at CCR1
ChEMBL 489 7 3 5 3.5 O=C(NC[C@@H](O)CN1CCC(Oc2ccc(Cl)c(Cl)c2)CC1)c1c[nH]c(=O)c2ccccc12 10.1016/j.bmcl.2012.09.113
162658125 180504 0 None -125 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 10.1021/acs.jmedchem.0c01137
CHEMBL4760108 180504 0 None -125 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 471 6 2 4 5.9 O=C(O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1 10.1021/acs.jmedchem.0c01137
162666730 181682 0 None -707 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 589 9 2 6 6.5 N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.0c01137
CHEMBL4783861 181682 0 None -707 3 Human 5.3 pIC50 = 5.3 Functional
Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting methodAntagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL3 stimulation and followed by further incubation for 90 mins by scintillation counting method
ChEMBL 589 9 2 6 6.5 N#CSCCNC(=O)c1ccc(Oc2ccc(Cl)cc2NS(=O)(=O)c2ccc(Cl)c(C(F)(F)F)c2)cc1 10.1021/acs.jmedchem.0c01137
44453436 97185 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
CHEMBL271079 97185 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1 10.1016/j.bmcl.2007.09.068
44453293 166839 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
CHEMBL429591 166839 0 None - 1 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br 10.1016/j.bmcl.2007.09.068
9869274 118795 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 468 5 1 3 6.4 N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 10.1021/jm990316l
CHEMBL344073 118795 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 468 5 1 3 6.4 N#CC1(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc2C=Cc2ccccc21 10.1021/jm990316l
44430745 141507 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL387822 141507 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
ChEMBL 544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
10111333 174884 0 None -19 2 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4577133 174884 0 None -19 2 Human 6.3 pIC50 = 6.3 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
58138841 169058 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4437170 169058 0 None - 1 Human 7.3 pIC50 = 7.3 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 438 6 2 5 3.0 CNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
512282 745 55 None 9 3 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
767 745 55 None 9 3 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
CHEMBL232656 745 55 None 9 3 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F 10.1016/j.bmcl.2005.08.057
44405202 72633 0 None 17 2 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
CHEMBL200794 72633 0 None 17 2 Human 6.3 pIC50 = 6.3 Functional
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
ChEMBL 442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12 10.1016/j.bmcl.2005.08.057
10576419 33961 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 9 1 3 6.7 N#CC(CCCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL142620 33961 0 None - 1 Human 5.3 pIC50 = 5.3 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 472 9 1 3 6.7 N#CC(CCCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1 10.1021/jm990316l
CHEMBL3138380 209365 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
CHEMBL3138437 209365 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
ChEMBL None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc([N+](=O)[O-])c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C 10.1016/s0960-894x(00)00601-6
10001921 72093 0 None 3 2 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
CHEMBL198852 72093 0 None 3 2 Human 7.2 pIC50 = 7.2 Functional
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
ChEMBL 415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1 10.1016/j.bmcl.2005.08.057
11743399 72123 12 None -32 2 Mouse 6.2 pIC50 = 6.2 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL198949 72123 12 None -32 2 Mouse 6.2 pIC50 = 6.2 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
10572669 118923 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 393 6 1 4 4.6 N#Cc1ccccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
CHEMBL344989 118923 0 None - 1 Human 5.2 pIC50 = 5.2 Functional
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
ChEMBL 393 6 1 4 4.6 N#Cc1ccccc1C(C#N)CCCN1CCC(O)(c2ccc(Cl)cc2)CC1 10.1021/jm990316l
3497 1154 20 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 482 11 4 6 2.5 O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C 10.1016/j.bmcl.2018.11.015
5311123 1154 20 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 482 11 4 6 2.5 O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C 10.1016/j.bmcl.2018.11.015
CHEMBL1628706 1154 20 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 482 11 4 6 2.5 O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C 10.1016/j.bmcl.2018.11.015
44453499 154852 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 4 1 4 4.3 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL403613 154852 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 4 1 4 4.3 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)c(Cl)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
10111333 174884 0 None -19 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
CHEMBL4577133 174884 0 None -19 2 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
ChEMBL 395 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Br)cc2F)C1C1CCCCC1 10.1021/acs.jmedchem.8b00605
44430748 86779 0 None 1 3 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL232837 86779 0 None 1 3 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
44430758 142266 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 482 6 2 6 3.1 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
CHEMBL389293 142266 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
ChEMBL 482 6 2 6 3.1 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1Nc1c(N)c(=O)c1=O 10.1016/j.bmcl.2007.03.104
25233756 180290 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 467 4 1 2 5.6 Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
CHEMBL475748 180290 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
ChEMBL 467 4 1 2 5.6 Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1 10.1021/jm801416q
58138880 171776 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
CHEMBL4475918 171776 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 452 6 1 5 3.3 CN(C)S(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1 10.1016/j.bmcl.2018.12.024
44405212 72607 0 None 1 2 Human 8.2 pIC50 = 8.2 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
CHEMBL200680 72607 0 None 1 2 Human 8.2 pIC50 = 8.2 Functional
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
ChEMBL 458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2 10.1016/j.bmcl.2005.08.057
25253284 15993 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 450 4 1 5 4.8 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
CHEMBL1224119 15993 0 None - 1 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
ChEMBL 450 4 1 5 4.8 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1 10.1016/j.bmcl.2010.07.082
59278314 169340 16 None 54 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
CHEMBL4441094 169340 16 None 54 2 Human 8.2 pIC50 = 8.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1 10.1016/j.bmcl.2018.12.024
11211557 169276 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 393 4 1 3 4.8 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
CHEMBL4440166 169276 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 393 4 1 3 4.8 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)cc1 10.1016/j.bmcl.2018.11.015
10456104 71623 0 None -56 2 Mouse 6.2 pIC50 = 6.2 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
CHEMBL197375 71623 0 None -56 2 Mouse 6.2 pIC50 = 6.2 Functional
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
ChEMBL 443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C 10.1016/j.bmcl.2005.08.057
59278235 172506 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cncc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4519965 172506 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 425 5 1 7 2.3 CS(=O)(=O)c1cncc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
44468708 174109 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 423 5 1 5 3.5 CS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
CHEMBL4559388 174109 0 None - 1 Human 7.2 pIC50 = 7.2 Functional
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
ChEMBL 423 5 1 5 3.5 CS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1 10.1016/j.bmcl.2018.12.024
44453466 155097 0 None - 1 Human 6.2 pIC50 = 6.2 Functional
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
ChEMBL 486 4 1 4 4.3 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(F)c3)CC2)CC1 10.1016/j.bmcl.2007.09.068
CHEMBL404757 155097 0 None - 1 Human