Purchasability


Ligand source activities (1 row/activity)

Select all ChEMBL ID Receptor Species Purchasable p-value
(-log)
Activity
Type
Activity
Relation
Activity
Value
Unit Assay Type Assay Description Mol
weight
Rot
Bonds
H don H acc LogP Smiles
CHEMBL316589 ccr1_human Human Yes 6.0 EC50 = 1000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1ccnc2c1ccc1cccnc12
CHEMBL2205802 ccr1_human Human Yes 5.0 EC50 = 10000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
240 2 2 4 1.8 OCc1ccc2ccc3ccc(CO)nc3c2n1
CHEMBL2205808 ccr1_human Human Yes 5.0 EC50 = 10000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
216 3 0 4 2.2 COc1ccnc(-c2cc(OC)ccn2)c1
CHEMBL2205805 ccr1_human Human Yes 5.9 EC50 = 1200 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1
CHEMBL2205806 ccr1_human Human Yes 4.9 EC50 = 12000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1
CHEMBL2205805 ccr1_human Human Yes 5.9 EC50 = 1258.9 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
267 2 0 3 3.9 Clc1cc(-c2ccccn2)nc(-c2ccccn2)c1
CHEMBL2205810 ccr1_human Human Yes 5.9 EC50 = 1258.9 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1
CHEMBL2205803 ccr1_human Human Yes 4.9 EC50 = 12589.3 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1
CHEMBL2205806 ccr1_human Human Yes 4.9 EC50 = 12589.3 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1cccc(-c2cccc(C)n2)n1
CHEMBL2205810 ccr1_human Human Yes 5.9 EC50 = 1300 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1cnc2c(ccc3cccnc32)c1
CHEMBL2205803 ccr1_human Human Yes 4.9 EC50 = 13000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 2 0 4 2.4 O=Cc1ccc2ccc3ccc(C=O)nc3c2n1
CHEMBL99384 ccr1_human Human Yes 5.8 EC50 = 1500 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C
CHEMBL1976682 ccr1_human Human Yes 4.8 EC50 = 15000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1
CHEMBL375781 ccr1_human Human Yes 5.8 EC50 = 1584.9 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1
CHEMBL99384 ccr1_human Human Yes 5.8 EC50 = 1584.9 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 0 0 2 4.0 Cc1cnc2c(ccc3c(C)c(C)cnc32)c1C
CHEMBL1976682 ccr1_human Human Yes 4.8 EC50 = 15848.9 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
364 2 0 2 4.6 BrCc1ccc2ccc3ccc(CBr)nc3c2n1
CHEMBL2205807 ccr1_human Human Yes 4.8 EC50 = 15848.9 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1
CHEMBL375781 ccr1_human Human Yes 5.8 EC50 = 1600 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1ccc2ccc3ccc(C)nc3c2n1
CHEMBL2205807 ccr1_human Human Yes 4.8 EC50 = 17000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1ccc(-c2ccc(C)cn2)nc1
CHEMBL98682 ccr1_human Human Yes 5.8 EC50 = 1800 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12
CHEMBL317115 ccr1_human Human Yes 5.7 EC50 = 1995.3 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12
CHEMBL98682 ccr1_human Human Yes 5.7 EC50 = 1995.3 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
194 0 0 2 3.1 Cc1cc2cccnc2c2ncccc12
CHEMBL66165 ccr1_human Human No 5.7 EC50 = 2000 nM Funct
Agonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopyAgonist activity at human CCR1 expressed in CHO cells by cellular dielectric spectroscopy
410 7 2 4 6.4 Clc1ccc2c(NCCCCNc3ccnc4cc(Cl)ccc34)ccnc2c1
CHEMBL317115 ccr1_human Human Yes 5.7 EC50 = 2000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
214 0 0 2 3.4 Clc1cc2cccnc2c2ncccc12
CHEMBL39879 ccr1_human Human Yes 4.5 EC50 = 31622.8 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1
CHEMBL39879 ccr1_human Human Yes 4.5 EC50 = 34000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
156 1 0 2 2.1 c1ccc(-c2ccccn2)nc1
CHEMBL101165 ccr1_human Human Yes 5.4 EC50 = 3600 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1
CHEMBL101165 ccr1_human Human Yes 5.4 EC50 = 3981.1 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1
CHEMBL2205809 ccr1_human Human Yes 5.3 EC50 = 4900 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1
CHEMBL2205801 ccr1_human Human Yes 5.3 EC50 = 5000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12
CHEMBL2205801 ccr1_human Human Yes 5.3 EC50 = 5011.9 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
236 2 0 4 2.4 O=Cc1ccnc2c1ccc1c(C=O)ccnc12
CHEMBL2205809 ccr1_human Human Yes 5.3 EC50 = 5011.9 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1cnc2c(ccc3cc(C)cnc32)c1
CHEMBL415879 ccr1_human Human Yes 5.2 EC50 = 5900 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
180 0 0 2 2.8 c1cnc2c(c1)ccc1cccnc12
CHEMBL415879 ccr1_human Human Yes 5.2 EC50 = 6309.6 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
180 0 0 2 2.8 c1cnc2c(c1)ccc1cccnc12
CHEMBL89445 ccr1_human Human Yes 4.2 EC50 = 63095.7 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1
CHEMBL89445 ccr1_human Human Yes 4.2 EC50 = 64000 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
233 2 0 3 3.2 c1ccc(-c2cccc(-c3ccccn3)n2)nc1
CHEMBL593442 ccr1_human Human Yes 6.1 EC50 = 794.3 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12
CHEMBL593442 ccr1_human Human Yes 6.1 EC50 = 850 nM Funct
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysisAllosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12
CHEMBL4128926 ccr1_human Human No 10.1 IC50 = 0.1 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 receptor after 120 mins by scintillation counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 receptor after 120 mins by scintillation counting analysis
583 8 3 6 5.8 CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12
CHEMBL519240 ccr1_human Human Yes 10.1 IC50 = 0.1 nM Bind
Displacement of radiolabeled MIP1alpha from human CCR1 receptorDisplacement of radiolabeled MIP1alpha from human CCR1 receptor
327 1 2 6 1.7 Nc1nc2c(c(N3CCNCC3)n1)CCC1=C2[C@@H]2CCCC[C@@H]2O1
CHEMBL197375 ccr1_human Human No 10.0 IC50 = 0.1 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL4457209 ccr1_human Human No 9.7 IC50 = 0.2 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
453 6 1 7 3.2 CCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1
CHEMBL4464625 ccr1_human Human No 9.7 IC50 = 0.2 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1
CHEMBL4464625 ccr1_human Human No 9.5 IC50 = 0.3 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1
CHEMBL4475581 ccr1_human Human No 9.5 IC50 = 0.3 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
467 7 1 7 3.6 CCCC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1
CHEMBL2332935 ccr1_human Human No 9.4 IC50 = 0.4 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
446 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2332933 ccr1_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
432 6 2 5 3.1 CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL2332935 ccr1_human Human No 9.4 IC50 = 0.4 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
446 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL232656 ccr1_human Human Yes 9.4 IC50 = 0.4 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL2332936 ccr1_human Human No 9.3 IC50 = 0.5 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
430 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL2332936 ccr1_human Human No 9.3 IC50 = 0.5 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
430 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL3099947 ccr1_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
471 7 4 6 3.0 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1
CHEMBL2332931 ccr1_human Human No 9.2 IC50 = 0.6 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
448 6 2 5 3.6 CC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL3679659 ccr1_human Human No 9.2 IC50 = 0.7 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
493 5 4 4 3.8 C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O
CHEMBL3679659 ccr1_human Human No 9.2 IC50 = 0.7 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
493 5 4 4 3.8 C[C@H](NC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O
CHEMBL277930 ccr1_human Human Yes 9.1 IC50 = 0.7 nM Funct
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL331897 ccr1_human Human Yes 9.1 IC50 = 0.7 nM Funct
Inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptorInhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing human CCR1 receptor
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL2332940 ccr1_human Human No 9.1 IC50 = 0.8 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
445 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2322875 ccr1_human Human No 9.1 IC50 = 0.8 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL5/RANTES-induced chemotaxis
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL4571977 ccr1_human Human No 9.1 IC50 = 0.8 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2
CHEMBL2398726 ccr1_human Human No 9.1 IC50 = 0.8 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398729 ccr1_human Human No 9.1 IC50 = 0.8 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3099945 ccr1_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
487 7 4 6 3.5 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1
CHEMBL196860 ccr1_human Human No 9.1 IC50 = 0.9 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O
CHEMBL277930 ccr1_human Human Yes 9.1 IC50 = 0.9 nM Bind
Binding affinity towards C-C chemokine receptor type 1Binding affinity towards C-C chemokine receptor type 1
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL331897 ccr1_human Human Yes 9.1 IC50 = 0.9 nM Bind
Binding affinity towards C-C chemokine receptor type 1Binding affinity towards C-C chemokine receptor type 1
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL277930 ccr1_human Human Yes 9.1 IC50 = 0.9 nM Bind
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL331897 ccr1_human Human Yes 9.1 IC50 = 0.9 nM Bind
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL2332930 ccr1_human Human No 9.1 IC50 = 0.9 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
460 7 2 6 3.5 COc1ccc(NC(C)=O)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1
CHEMBL277930 ccr1_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL331897 ccr1_human Human Yes 9.1 IC50 = 0.9 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL2391803 ccr1_human Human No 9.0 IC50 = 0.9 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
536 6 3 7 3.1 O=C(c1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1
CHEMBL2332932 ccr1_human Human No 9.0 IC50 = 1.0 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
430 6 2 5 3.5 CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2332934 ccr1_human Human No 9.0 IC50 = 1.0 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
414 6 2 5 3.0 CC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL2398726 ccr1_human Human No 9.0 IC50 = 1 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of RANTES-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL197345 ccr1_human Human No 9.0 IC50 = 1 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C
CHEMBL198949 ccr1_human Human Yes 9.0 IC50 = 1 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL372807 ccr1_human Human No 9.0 IC50 = 1 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl
CHEMBL2398717 ccr1_human Human No 9.0 IC50 = 1 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
420 6 2 3 3.7 CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3679651 ccr1_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
533 5 3 5 3.0 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2398716 ccr1_human Human Yes 9.0 IC50 = 1 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 9.0 IC50 = 1 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334818 ccr1_human Human No 9.0 IC50 = 1 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
471 6 3 3 4.3 CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL66159 ccr1_human Human No 9.0 IC50 = 1 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
481 11 4 6 2.9 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NN
CHEMBL4464625 ccr1_human Human No 9.0 IC50 = 1 nM Bind
Inhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysisInhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysis
453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1
CHEMBL3679651 ccr1_human Human No 9.0 IC50 = 1 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
533 5 3 5 3.0 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(S(N)(=O)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2391810 ccr1_human Human No 9.0 IC50 = 1.1 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
516 6 3 7 2.9 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCC(O)CC1
CHEMBL232656 ccr1_human Human Yes 9.0 IC50 = 1.1 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL2398728 ccr1_human Human No 9.0 IC50 = 1.1 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398744 ccr1_human Human No 8.9 IC50 = 1.2 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
436 7 2 3 4.4 CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL4518015 ccr1_human Human No 8.9 IC50 = 1.2 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
492 5 1 6 3.9 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc(C(F)(F)F)c1
CHEMBL2398769 ccr1_human Human No 8.9 IC50 = 1.2 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
457 6 2 4 3.6 CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL277930 ccr1_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL331897 ccr1_human Human Yes 8.9 IC50 = 1.2 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL2391797 ccr1_human Human No 8.9 IC50 = 1.3 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
529 7 2 7 3.0 CN(C)[C@@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1
CHEMBL232656 ccr1_human Human Yes 8.9 IC50 = 1.3 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL3679655 ccr1_human Human No 8.9 IC50 = 1.3 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
446 4 2 3 4.3 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)C2CCCC2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3099942 ccr1_human Human No 8.9 IC50 = 1.3 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
461 6 4 6 3.0 CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL3679655 ccr1_human Human No 8.9 IC50 = 1.3 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
446 4 2 3 4.3 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)C2CCCC2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2391795 ccr1_human Human No 8.9 IC50 = 1.4 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
472 7 3 6 3.1 O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2391939 ccr1_human Human No 8.9 IC50 = 1.4 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
474 7 2 5 3.6 O=C(NC1CC1)c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL4562738 ccr1_human Human No 8.9 IC50 = 1.4 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
439 5 1 7 2.8 CC(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1
CHEMBL2398747 ccr1_human Human No 8.9 IC50 = 1.4 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
434 5 2 3 4.1 CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3099940 ccr1_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
485 6 2 5 4.2 O=C(Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1
CHEMBL2332941 ccr1_human Human No 8.9 IC50 = 1.4 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
429 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL2322875 ccr1_human Human No 8.8 IC50 = 1.5 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced chemotaxis
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2398716 ccr1_human Human Yes 8.8 IC50 = 1.5 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 8.8 IC50 = 1.5 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL232656 ccr1_human Human Yes 8.8 IC50 = 1.5 nM Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL200629 ccr1_human Human No 8.8 IC50 = 1.5 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl
CHEMBL4436541 ccr1_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
471 5 2 4 4.4 Cc1cc(C)c(C(=O)NC(C)(C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)cn1
CHEMBL4594791 ccr1_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
471 5 2 4 4.4 Cc1cc(C)c(C(=O)NC(C)(C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)cn1
CHEMBL3679653 ccr1_human Human No 8.8 IC50 = 1.5 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@H]2CC[C@@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679653 ccr1_human Human No 8.8 IC50 = 1.5 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@H]2CC[C@@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2398728 ccr1_human Human No 8.8 IC50 = 1.6 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3679654 ccr1_human Human No 8.8 IC50 = 1.6 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
498 5 3 4 4.1 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679654 ccr1_human Human No 8.8 IC50 = 1.6 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
498 5 3 4 4.1 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2398739 ccr1_human Human No 8.8 IC50 = 1.7 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
484 8 2 3 5.0 CC(C)[C@@H](NC(=O)CCCc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398744 ccr1_human Human No 8.8 IC50 = 1.7 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
436 7 2 3 4.4 CC(C)CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL4574123 ccr1_human Human No 8.8 IC50 = 1.7 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
434 5 2 3 4.3 CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)C1CCCC1
CHEMBL2391793 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
446 6 3 6 2.6 CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2391808 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
486 6 2 6 3.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCC1
CHEMBL4571977 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
532 5 2 5 6.3 CC(C)(O)c1ccc2c(c1)/C(=C\CCN1CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C1)c1cccnc1CO2
CHEMBL2398737 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
456 6 2 3 4.2 CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL4456123 ccr1_human Human Yes 8.7 IC50 = 1.8 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1
CHEMBL2398746 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
420 5 2 3 3.7 CC(C)[C@@H](NC(=O)C1CCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL4476397 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
485 6 3 4 3.5 CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1cccc(C(N)=O)c1
CHEMBL3679656 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
497 5 3 4 3.5 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(N)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3099943 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
521 7 4 6 4.2 O=C(Nc1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1
CHEMBL3099944 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
501 8 3 6 3.8 COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1
CHEMBL3679656 ccr1_human Human No 8.7 IC50 = 1.8 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
497 5 3 4 3.5 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)c2cccc(C(N)=O)c2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2391804 ccr1_human Human No 8.7 IC50 = 1.9 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1
CHEMBL2398743 ccr1_human Human No 8.7 IC50 = 1.9 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
422 6 2 3 4.0 CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL4466344 ccr1_human Human No 8.7 IC50 = 1.9 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
467 6 4 4 3.4 C[C@H](NC(=O)NC(C)(C)CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)(C)O
CHEMBL1183314 ccr1_human Human No 8.7 IC50 = 1.9 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL289902 ccr1_human Human No 8.7 IC50 = 1.9 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL3334727 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398761 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
442 5 2 3 4.2 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398771 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
476 5 2 3 4.9 CC(C)[C@@H](NC(=O)c1cccc(Cl)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL4436061 ccr1_human Human No 8.0 IC50 = 10 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
453 6 1 3 6.3 CCC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F
CHEMBL200242 ccr1_human Human No 8.0 IC50 = 10 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2
CHEMBL2398762 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
432 5 2 3 4.3 CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2321887 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
460 5 0 7 2.3 COc1cc(N2CCN(C(=O)Cn3nc(S(C)(=O)=O)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2322847 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
407 4 0 6 2.7 COc1cc(N2CCN(C(=O)Cn3nc(C#N)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2322867 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
466 5 1 6 3.1 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3CO)CC2)ccc1Cl
CHEMBL2322880 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
484 4 0 5 4.5 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Cl)c1Cl
CHEMBL232441 ccr1_human Human No 8.0 IC50 = 10 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O
CHEMBL4441094 ccr1_human Human Yes 8.0 IC50 = 10 nM Bind
Inhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysisInhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysis
425 5 1 7 2.3 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1
CHEMBL256821 ccr1_human Human No 7.0 IC50 = 100 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1
CHEMBL257509 ccr1_human Human No 7.0 IC50 = 100 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl
CHEMBL197345 ccr1_human Human No 7.0 IC50 = 100 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C
CHEMBL2322874 ccr1_human Human No 7.0 IC50 = 100 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
434 3 0 4 4.2 Cc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2180511 ccr1_human Human No 7.0 IC50 = 100 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
426 5 1 2 5.1 Cc1cccc(C(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)c1C
CHEMBL199412 ccr1_mouse Mouse No 6.0 IC50 = 1000 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL198966 ccr1_human Human No 6.0 IC50 = 1000 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12
CHEMBL200794 ccr1_human Human No 6.0 IC50 = 1000 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12
CHEMBL397910 ccr1_mouse Mouse No 6.0 IC50 = 1000 nM Bind
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O
CHEMBL270563 ccr1_human Human No 6.0 IC50 = 1000 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
477 4 0 4 4.7 N#CC1(c2ccc(Cl)cc2)CCN(C2CCN(S(=O)(=O)c3ccccc3Cl)CC2)CC1
CHEMBL83338 ccr1_human Human Yes 5.0 IC50 = 10000 nM Bind
Compound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR1 receptorCompound concentration that causes 50 % inhibition of binding of specific radioligand to human CCR1 receptor
556 8 0 4 5.3 CN(C[C@@H](CCN1CCC2(CC1)C[S+]([O-])c1ccccc12)c1cccc(Cl)c1)S(=O)(=O)c1ccccc1
CHEMBL195433 ccr1_human Human Yes 5.0 IC50 = 10000 nM Bind
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
486 7 2 5 5.4 CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C
CHEMBL363840 ccr1_human Human No 5.0 IC50 = 10000 nM Bind
Inhibition of C-C chemokine receptor type 1Inhibition of C-C chemokine receptor type 1
505 7 2 6 4.7 Cn1nnnc1-c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)c1
CHEMBL3137848 ccr1_human Human No 5.0 IC50 = 10000 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
880 16 6 6 11.0 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)c5cc(Cl)c(O)c(C(=O)NCC(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL3138130 ccr1_human Human No 5.0 IC50 = 10000 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL3138370 ccr1_human Human No 5.0 IC50 = 10000 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(C(=O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL101165 ccr1_human Human Yes 4.0 IC50 = 100000 nM Bind
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsDisplacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
184 1 0 2 2.8 Cc1ccnc(-c2cc(C)ccn2)c1
CHEMBL593442 ccr1_human Human Yes 4.0 IC50 = 100000 nM Bind
Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsDisplacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
208 0 0 2 3.4 Cc1ccnc2c1ccc1c(C)ccnc12
CHEMBL3099947 q9jly8_rat Rat No 7.0 IC50 = 101 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
471 7 4 6 3.0 O=C(Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)NC1CC1
CHEMBL258368 ccr1_human Human No 6.0 IC50 = 1020 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
440 4 1 5 3.5 O=S(=O)(c1cccs1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL306683 ccr1_human Human No 5.0 IC50 = 10300 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
446 10 3 3 4.3 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2c1
CHEMBL2180194 ccr1_human Human No 7.0 IC50 = 105 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
440 7 1 2 5.1 Cc1ccc(CCC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1
CHEMBL197345 ccr1_human Human No 5.0 IC50 = 10500 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C
CHEMBL3679640 ccr1_human Human No 6.0 IC50 = 1065 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
526 4 2 5 4.1 CC1(C)CN(C(=O)[C@H]2CC3(CC[C@H]2NC(=O)c2ccccc2)OCCO3)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679640 ccr1_human Human No 6.0 IC50 = 1065 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
526 4 2 5 4.1 CC1(C)CN(C(=O)[C@H]2CC3(CC[C@H]2NC(=O)c2ccccc2)OCCO3)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2398768 ccr1_human Human No 7.0 IC50 = 107 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
413 6 1 3 3.8 CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2322878 ccr1_human Human No 7.0 IC50 = 107 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
464 4 0 5 4.2 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C)c1Cl
CHEMBL2180518 ccr1_human Human No 6.0 IC50 = 1077 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
428 6 1 3 5.0 CC(C)C(NC(=O)OCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL143499 ccr1_human Human No 5.0 IC50 = 10900 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
435 7 1 4 5.1 N#Cc1ccc(C2(O)CCN(CCCC(C#N)(c3ccccc3)c3ccccc3)CC2)cc1
CHEMBL2322854 ccr1_human Human No 8.0 IC50 = 11 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
480 5 1 6 3.2 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@H](CO)C2)ccc1Cl
CHEMBL475748 ccr1_human Human No 8.0 IC50 = 11 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
467 4 1 2 5.6 Cc1cc(C(F)(F)F)cc(C)c1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1
CHEMBL3334820 ccr1_human Human No 8.0 IC50 = 11 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
424 6 3 4 2.7 CC(C)[C@@H](NC(=O)C[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL4443024 ccr1_human Human No 8.0 IC50 = 11.3 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
503 5 3 5 3.7 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2cccc(C(=O)O)c2)CC[C@]1(O)c1ccc(C#N)cc1
CHEMBL3679657 ccr1_human Human No 8.0 IC50 = 11.3 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
503 5 3 4 4.4 [C-]#[N+]c1ccc([C@@]2(O)CCN(C(=O)[C@H]3CCCC[C@H]3NC(=O)c3cccc(C(=O)O)c3)CC2(C)C)cc1
CHEMBL3679639 ccr1_human Human No 7.9 IC50 = 11.5 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
469 4 3 3 4.8 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679639 ccr1_human Human No 7.9 IC50 = 11.5 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
469 4 3 3 4.8 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2391805 ccr1_human Human No 7.0 IC50 = 110 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
529 7 2 7 3.0 CN(C)[C@H]1CCN(C(=O)c2ccc(O)cc2OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)C1
CHEMBL255338 ccr1_human Human No 7.0 IC50 = 110 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1
CHEMBL269957 ccr1_human Human No 7.0 IC50 = 110 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl
CHEMBL2391809 q9jly8_rat Rat No 6.0 IC50 = 1100 nM Bind
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
500 6 2 6 3.9 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCCCC1
CHEMBL4552741 ccr1_human Human No 6.0 IC50 = 1100 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1cccc(F)c1
CHEMBL2322865 ccr1_human Human No 6.0 IC50 = 1100 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
478 5 0 5 4.7 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C(C)C)CC2)ccc1Cl
CHEMBL286355 ccr1_human Human No 6.0 IC50 = 1100 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
418 6 1 2 5.8 O=C(NC1CCN(CC2CCCCCCC2)CC1)C(c1ccccc1)c1ccccc1
CHEMBL2322873 ccr1_human Human No 5.0 IC50 = 11000 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
420 3 0 4 3.9 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2cccc(Cl)c2)CC1
CHEMBL256887 ccr1_human Human No 6.0 IC50 = 1120 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL2391795 q9jly8_rat Rat No 6.9 IC50 = 114 nM Bind
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
472 7 3 6 3.1 O=C(NC1CC1)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2180188 ccr1_human Human No 6.9 IC50 = 115 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
446 6 1 2 5.1 CC(C)[C@@H](NC(=O)Cc1ccc(Cl)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL271079 ccr1_human Human No 5.9 IC50 = 1150 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1
CHEMBL270358 ccr1_human Human No 5.9 IC50 = 1170 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1
CHEMBL2180507 ccr1_human Human No 6.9 IC50 = 118 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
416 5 1 2 4.6 CC(C)[C@@H](NC(=O)c1ccc(F)cc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL66457 ccr1_human Human No 5.9 IC50 = 1180 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
464 11 4 6 2.4 CC(C)(O)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O
CHEMBL308690 ccr1_human Human No 4.9 IC50 = 11800 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
413 10 3 4 3.5 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC(C)C)NC(=O)c1cnc2ccccc2c1
CHEMBL4460796 ccr1_human Human No 5.9 IC50 = 1181 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
484 5 2 4 4.2 CC1(C)CN(C(=O)CC2(NC(=O)c3ccccc3)CCOCC2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL4573109 ccr1_human Human No 5.9 IC50 = 1188 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
442 5 2 3 4.2 CC(NC(=O)c1ccccc1)C(C)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 nM Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O
CHEMBL2391802 ccr1_human Human No 7.9 IC50 = 12 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
488 6 2 6 2.4 O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2)N1CC[C@H](O)C1
CHEMBL2391812 ccr1_human Human No 7.9 IC50 = 12 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
476 8 4 7 2.0 O=C(NCCO)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2398727 ccr1_human Human No 7.9 IC50 = 12 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 nM Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O
CHEMBL4442765 ccr1_human Human No 7.9 IC50 = 12 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1
CHEMBL4464575 ccr1_human Human No 7.9 IC50 = 12 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
453 5 1 7 3.0 CC(C)(NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1
CHEMBL4586189 ccr1_human Human No 7.9 IC50 = 12 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
507 6 1 6 3.0 CN1CCN(S(=O)(=O)c2ccc(CNC(=O)c3cccc4c3cnn4-c3ccc(F)cc3)cc2)CC1
CHEMBL2322875 ccr1_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cellsDisplacement of [125I]-CCL15/Leukotactin1 from CCR1 in human THP1 cells
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2322876 ccr1_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
464 5 0 5 4.3 CCOc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2322886 ccr1_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
480 5 1 6 3.4 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CO)c1Cl
CHEMBL234295 ccr1_human Human No 7.9 IC50 = 12 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O
CHEMBL1183314 ccr1_mouse Mouse No 7.9 IC50 = 12 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL289902 ccr1_mouse Mouse No 7.9 IC50 = 12 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
615 5 1 2 7.8 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL277930 ccr1_mouse Mouse Yes 7.9 IC50 = 12 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL331897 ccr1_mouse Mouse Yes 7.9 IC50 = 12 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL3679638 ccr1_human Human No 7.9 IC50 = 12.1 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
450 3 2 4 4.5 CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3679638 ccr1_human Human No 7.9 IC50 = 12.1 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
450 3 2 4 4.5 CC(C)(C)OC(=O)N[C@@H]1CCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL256272 ccr1_human Human No 6.9 IC50 = 120 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br
CHEMBL258064 ccr1_human Human No 6.9 IC50 = 120 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1
CHEMBL4471579 ccr1_human Human No 6.9 IC50 = 120 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
424 5 1 6 2.9 CS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cn1
CHEMBL198966 ccr1_human Human No 6.9 IC50 = 120 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12
CHEMBL2322850 ccr1_human Human No 6.9 IC50 = 120 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
411 5 1 6 2.3 COc1cc(N2CCN(C(=O)Cn3nc(CN)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2322871 ccr1_human Human No 6.9 IC50 = 120 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
382 4 0 5 2.9 COc1cc(N2CCN(C(=O)Cn3ncc(Cl)c3C)CC2)ccc1Cl
CHEMBL473531 ccr1_human Human No 6.9 IC50 = 120 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl
CHEMBL2180538 ccr1_human Human No 6.9 IC50 = 120 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
398 6 1 2 4.6 CCCC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL306457 ccr1_human Human No 6.9 IC50 = 120 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
476 9 4 6 2.5 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1(O)CCCCC1
CHEMBL4539264 ccr1_human Human No 5.9 IC50 = 1200 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
427 4 1 3 5.4 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)cnn1-c1ccc(Cl)c(Cl)c1
CHEMBL4450029 ccr1_human Human No 5.9 IC50 = 1200 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
413 4 1 3 5.1 O=C(NCc1ccccc1C(F)(F)F)c1cccc2c1cnn2-c1ccc(F)cc1
CHEMBL4464403 ccr1_human Human No 5.9 IC50 = 1200 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
409 5 2 4 4.0 O=C(NCc1cccc(C(F)(F)F)c1)c1cnn(-c2ccc(Cl)cc2)c1CO
CHEMBL4527255 ccr1_human Human No 5.9 IC50 = 1200 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
346 4 1 4 3.5 O=C(NCc1ccncc1)c1cccc2c1cnn2-c1ccc(F)cc1
CHEMBL2180494 ccr1_human Human No 6.9 IC50 = 121 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 5 1 2 5.4 O=C(N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C1CCCCC1)c1ccccc1
CHEMBL2180527 ccr1_human Human No 6.9 IC50 = 121 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
384 5 1 2 4.3 CC[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2398766 ccr1_human Human No 6.9 IC50 = 123 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
477 6 2 4 3.1 CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL270419 ccr1_human Human No 5.9 IC50 = 1240 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL341306 ccr1_human Human No 6.9 IC50 = 125 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
587 11 3 3 7.3 O=C(NCC1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL270358 ccr1_human Human No 5.9 IC50 = 1250 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
452 4 1 4 3.6 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(F)cc3)CC2)CC1
CHEMBL69876 ccr1_human Human No 4.9 IC50 = 12500 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1
CHEMBL3099951 q9jly8_rat Rat No 5.9 IC50 = 1260 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
444 5 2 6 2.9 O=C1COc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1
CHEMBL270419 ccr1_human Human No 5.9 IC50 = 1270 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
434 4 1 4 3.5 O=S(=O)(c1ccccc1)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL3138123 ccr1_human Human No 4.9 IC50 = 12700 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
None None None CSCC[C@H](NC(=O)c1cc(C(=CCC[C@H]2CC[C@@]3(C)C(CC[C@@H]4[C@@H]3CC[C@@]3(C)[C@H]4CC[C@@H]3C(C)CCCC(C)C)C2)c2cc(Cl)c(O)c(C(=O)N[C@@H](CCSC)C(=O)O)c2)cc(Cl)c1O)C(=O)O
CHEMBL427834 ccr1_human Human No 5.9 IC50 = 1290 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL2398763 ccr1_human Human No 7.9 IC50 = 13 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
476 5 3 4 4.1 CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL232638 ccr1_human Human No 7.9 IC50 = 13 nM Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O
CHEMBL4577357 ccr1_human Human No 7.9 IC50 = 13 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
439 5 1 3 5.9 CC[C@H](NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cccc(C(F)(F)F)c1F
CHEMBL370596 ccr1_human Human No 7.9 IC50 = 13 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL234263 ccr1_human Human No 7.9 IC50 = 13 nM Bind
Binding Affinity at CCL3Binding Affinity at CCL3
490 9 1 5 4.0 C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)CCC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1
CHEMBL2398740 ccr1_human Human No 7.9 IC50 = 13 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
380 4 2 3 2.9 CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL2322875 ccr1_human Human No 7.9 IC50 = 13 nM Bind
Displacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytesDisplacement of [125I]-CCL15/Leukotactin1 from CCR1 in human monocytes
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2180186 ccr1_human Human No 7.9 IC50 = 13 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
430 6 1 2 4.6 CC(C)[C@@H](NC(=O)Cc1ccccc1F)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL3099960 ccr1_human Human No 7.9 IC50 = 13 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
459 7 3 6 2.8 CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL68366 ccr1_human Human No 7.9 IC50 = 13 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
466 11 3 5 3.4 CC(C)(F)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O
CHEMBL2391801 ccr1_human Human No 6.9 IC50 = 130 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
470 6 2 6 2.2 O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1ccccc1O2)N1CC[C@H](O)C1
CHEMBL270253 ccr1_human Human No 6.9 IC50 = 130 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL404465 ccr1_human Human No 6.9 IC50 = 130 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL397910 q9jly8_rat Rat No 6.9 IC50 = 130 nM Bind
Binding affinity at rat CCR1Binding affinity at rat CCR1
577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O
CHEMBL2180539 ccr1_human Human No 6.9 IC50 = 130 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 6 1 2 4.9 CC(C)CC(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL69978 ccr1_human Human No 6.9 IC50 = 130 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
447 10 3 4 3.7 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2n1
CHEMBL69123 ccr1_human Human No 6.9 IC50 = 130 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
494 12 3 5 4.0 CCNC(=O)C(CCC(C)(C)F)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1
CHEMBL255797 ccr1_human Human No 5.9 IC50 = 1300 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL517261 ccr1_human Human No 5.9 IC50 = 1300 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
389 4 1 2 4.1 CN(Cc1ccc(F)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1
CHEMBL3099956 ccr1_human Human No 5.9 IC50 = 1300 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
445 5 2 7 3.7 Nc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1
CHEMBL3099957 ccr1_human Human No 5.9 IC50 = 1300 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
444 5 1 6 4.5 Cc1nc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2s1
CHEMBL1178588 ccr1_mouse Mouse No 5.9 IC50 = 1300 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
523 6 1 2 7.6 O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21
CHEMBL33586 ccr1_mouse Mouse No 5.9 IC50 = 1300 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
523 6 1 2 7.6 O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21
CHEMBL256449 ccr1_human Human No 5.9 IC50 = 1330 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1
CHEMBL257698 ccr1_human Human No 5.9 IC50 = 1340 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)cc(Cl)c1
CHEMBL340491 ccr1_human Human No 5.9 IC50 = 1340 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
603 10 3 3 7.5 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cc(F)ccc1F
CHEMBL197375 ccr1_human Human No 5.9 IC50 = 1350 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL232253 ccr1_human Human No 7.9 IC50 = 14 nM Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL2322881 ccr1_human Human No 7.9 IC50 = 14 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
528 4 0 5 4.6 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(Br)c1Cl
CHEMBL3679652 ccr1_human Human No 7.9 IC50 = 14 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@@H]2CC[C@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2180508 ccr1_human Human No 7.9 IC50 = 14 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
434 5 1 2 4.8 CC(C)[C@@H](NC(=O)c1ccc(F)c(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL1178601 ccr1_human Human No 7.9 IC50 = 14 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
447 4 1 2 6.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL34165 ccr1_human Human No 7.9 IC50 = 14 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
447 4 1 2 6.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL3679652 ccr1_human Human No 7.9 IC50 = 14 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
462 4 3 4 3.2 CC1(C)CN(C(=O)[C@H]2CCC[C@H]2NC(=O)[C@@H]2CC[C@H](O)C2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2398716 ccr1_human Human Yes 7.8 IC50 = 14.3 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 7.8 IC50 = 14.3 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3679650 ccr1_human Human No 7.8 IC50 = 14.6 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
465 5 4 4 3.0 C[C@@H](O)CNC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3679650 ccr1_human Human No 7.8 IC50 = 14.6 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
465 5 4 4 3.0 C[C@@H](O)CNC(=O)N[C@@H]1CCCC[C@@H]1C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL514611 ccr1_human Human Yes 6.9 IC50 = 140 nM Bind
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1
CHEMBL514611 ccr1_human Human Yes 6.9 IC50 = 140 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1
CHEMBL2180189 ccr1_human Human No 6.9 IC50 = 140 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
426 6 1 2 4.7 Cc1ccc(CC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1
CHEMBL232455 ccr1_human Human No 6.9 IC50 = 140 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
502 8 2 7 2.6 CNc1c(Nc2cc(F)c(F)cc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL429591 ccr1_human Human No 6.9 IC50 = 140 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
486 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Br
CHEMBL33074 ccr1_human Human No 6.9 IC50 = 140 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
432 4 1 3 5.9 O=C(NC1CCN(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21
CHEMBL1178581 ccr1_mouse Mouse No 6.9 IC50 = 140 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
617 5 1 2 7.9 CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL33340 ccr1_mouse Mouse No 6.9 IC50 = 140 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
617 5 1 2 7.9 CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL1185511 ccr1_mouse Mouse No 6.9 IC50 = 140 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
631 6 1 2 8.3 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL418589 ccr1_mouse Mouse No 6.9 IC50 = 140 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
631 6 1 2 8.3 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL402825 ccr1_human Human No 5.9 IC50 = 1400 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL402825 ccr1_human Human No 5.9 IC50 = 1400 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL2391796 q9jly8_rat Rat No 4.9 IC50 = 14000 nM Bind
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@@H](O)C1
CHEMBL2391804 q9jly8_rat Rat No 4.9 IC50 = 14000 nM Bind
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
502 6 3 7 2.5 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1
CHEMBL338624 ccr1_human Human No 5.9 IC50 = 1410 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
635 10 3 3 8.2 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1cccc(C(F)(F)F)c1
CHEMBL2180523 ccr1_human Human No 4.8 IC50 = 14930 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
398 5 1 2 4.5 CC(C)[C@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2180528 ccr1_human Human No 7.8 IC50 = 15 nM Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPRAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced calcium flux by FLIPR
398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2322875 ccr1_human Human No 7.8 IC50 = 15 nM Bind
Antagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxisAntagonist activity at CCR1 in human monocytes assessed as inhibition of CCL15/Leukotactin1-induced chemotaxis
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2398740 ccr1_human Human No 7.8 IC50 = 15 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
380 4 2 3 2.9 CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL4568048 ccr1_human Human No 7.8 IC50 = 15 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
446 7 1 6 3.9 CCCC(NC(=O)c1cnn(-c2ccc(Cl)cc2)c1C)c1cncc(S(C)(=O)=O)c1
CHEMBL2398734 ccr1_human Human No 7.8 IC50 = 15 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
443 5 2 4 3.6 CC(C)[C@@H](NC(=O)c1ccccn1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL428193 ccr1_human Human No 7.8 IC50 = 15 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccccn2)c(=O)c1=O
CHEMBL69659 ccr1_human Human No 7.8 IC50 = 15 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
490 9 3 6 3.0 CC1CC([C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)C(N)=O)CC(C)O1
CHEMBL3679646 ccr1_human Human No 7.8 IC50 = 15.7 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
496 6 2 3 5.1 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679646 ccr1_human Human No 7.8 IC50 = 15.7 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
496 6 2 3 5.1 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)CCc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL200680 ccr1_human Human No 6.8 IC50 = 150 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
458 5 1 4 4.2 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2
CHEMBL198852 ccr1_human Human No 6.8 IC50 = 150 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1
CHEMBL256404 ccr1_human Human No 6.8 IC50 = 150 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL33580 ccr1_human Human No 6.8 IC50 = 150 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
586 4 1 3 7.3 O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21
CHEMBL232656 ccr1_mouse Mouse Yes 5.8 IC50 = 1500 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL370596 ccr1_human Human No 5.8 IC50 = 1500 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
445 5 1 3 4.7 CC(=O)Nc1cc2ccccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL69822 ccr1_human Human No 4.8 IC50 = 15000 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
453 10 3 4 4.5 CNC(=O)[C@@H](CC(C)C)C[C@@H](O)[C@@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1
CHEMBL2180524 ccr1_human Human No 6.8 IC50 = 152 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
364 6 1 2 4.0 CC[C@@H](NC(=O)CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2180541 ccr1_human Human No 6.8 IC50 = 152 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 6 1 2 5.0 CCCC(NC(=O)c1ccccc1C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2398764 ccr1_human Human No 6.8 IC50 = 153 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
532 7 3 3 5.7 CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL3099948 q9jly8_rat Rat No 5.8 IC50 = 1580 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
447 6 4 6 2.7 NC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL1224118 ccr1_human Human No 7.8 IC50 = 16 nM Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
448 4 1 3 6.0 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCCC1c1nccn1Cc1ccc(Cl)cc1
CHEMBL473734 ccr1_human Human No 7.8 IC50 = 16 nM Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
453 4 1 2 5.3 Cc1cc(C(F)(F)F)ccc1NC(=O)N1CCC[C@@H]1C(=O)N(C)Cc1ccc(Cl)cc1
CHEMBL196860 ccr1_human Human No 7.8 IC50 = 16 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O
CHEMBL2322845 ccr1_human Human No 7.8 IC50 = 16 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
440 5 1 6 3.1 COc1cc(N2CCN(C(=O)Cn3nc(C(C)(C)O)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2322887 ccr1_human Human No 7.8 IC50 = 16 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
479 5 1 6 3.3 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(CN)c1Cl
CHEMBL3099943 q9jly8_rat Rat No 7.8 IC50 = 16 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
521 7 4 6 4.2 O=C(Nc1cc(Cl)c(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)NC1CC1
CHEMBL2398716 ccr1_human Human Yes 7.8 IC50 = 16.2 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 7.8 IC50 = 16.2 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL2391793 q9jly8_rat Rat No 6.8 IC50 = 160 nM Bind
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
446 6 3 6 2.6 CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL3099955 ccr1_human Human No 6.8 IC50 = 160 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
427 5 1 5 4.6 Cc1cc2c(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)cccc2o1
CHEMBL387821 ccr1_human Human No 6.8 IC50 = 160 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
557 11 2 8 2.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN(C)C)c(=O)c1=O
CHEMBL396700 ccr1_human Human No 6.8 IC50 = 160 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
484 8 2 7 2.5 CNc1c(Nc2cc(F)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL272097 ccr1_human Human No 6.8 IC50 = 160 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccs1
CHEMBL71242 ccr1_human Human No 6.8 IC50 = 160 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
516 10 3 5 4.4 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(Cl)c(Cl)c1)NC(=O)c1cnc2ccccc2n1
CHEMBL370447 ccr1_human Human No 5.8 IC50 = 1600 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL142199 ccr1_human Human No 5.8 IC50 = 1600 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
458 8 1 3 6.3 N#CC(CCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL33159 ccr1_human Human No 5.8 IC50 = 1600 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
434 6 2 3 4.9 O=C(NC1CCN(CC2CCCCCCC2)CC1)C(O)(c1ccccc1)c1ccccc1
CHEMBL2398720 ccr1_human Human No 5.8 IC50 = 1603 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
449 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3099950 q9jly8_rat Rat No 5.8 IC50 = 1620 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
449 6 3 5 3.2 NC(=O)Nc1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL256264 ccr1_human Human No 5.8 IC50 = 1650 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
422 6 2 3 4.6 O=C(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc2ccccc2c1
CHEMBL332277 ccr1_human Human No 6.8 IC50 = 167 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
568 10 3 4 6.6 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)Nc1ccncc1
CHEMBL387608 ccr1_mouse Mouse No 5.8 IC50 = 1670 nM Bind
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O
CHEMBL305420 ccr1_human Human No 4.8 IC50 = 16700 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
463 10 4 5 3.4 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc2ccccc2nc1O
CHEMBL231829 ccr1_human Human No 7.8 IC50 = 17 nM Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL4449996 ccr1_human Human No 7.8 IC50 = 17 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)nc1
CHEMBL232837 q9jly8_rat Rat No 7.8 IC50 = 17 nM Bind
Binding affinity at rat CCR1Binding affinity at rat CCR1
529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O
CHEMBL2398725 ccr1_human Human No 7.8 IC50 = 17 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
449 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@H]1N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL1224188 ccr1_human Human No 7.8 IC50 = 17 nM Bind
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1
CHEMBL1178597 ccr1_human Human No 7.8 IC50 = 17 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
515 4 1 2 7.3 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL33929 ccr1_human Human No 7.8 IC50 = 17 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
515 4 1 2 7.3 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL3679641 ccr1_human Human No 7.8 IC50 = 17.2 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
482 4 2 4 4.0 CC1(C)CN(C(=O)[C@H]2CC(=O)CC[C@H]2NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679641 ccr1_human Human No 7.8 IC50 = 17.2 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
482 4 2 4 4.0 CC1(C)CN(C(=O)[C@H]2CC(=O)CC[C@H]2NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL4544186 ccr1_human Human No 6.8 IC50 = 170 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
452 7 2 5 3.4 CCNS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1
CHEMBL234081 ccr1_human Human No 6.8 IC50 = 170 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
528 10 2 7 3.8 CCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL4440452 ccr1_human Human No 5.8 IC50 = 1700 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
403 5 1 5 3.9 COC(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1
CHEMBL4565390 ccr1_human Human No 5.8 IC50 = 1700 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
403 5 1 5 3.2 Cc1c(C(=O)NCc2ccc(S(C)(=O)=O)cc2)cnn1-c1ccc(Cl)cc1
CHEMBL196908 ccr1_human Human No 5.8 IC50 = 1700 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
427 5 1 3 3.9 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1
CHEMBL370162 ccr1_human Human No 5.8 IC50 = 1700 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL2180531 ccr1_human Human No 6.8 IC50 = 172 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
458 5 2 3 3.7 CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Br)cc2)CC1
CHEMBL3099942 q9jly8_rat Rat No 5.8 IC50 = 1760 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
461 6 4 6 3.0 CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2180512 ccr1_human Human No 6.8 IC50 = 177 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
426 5 1 2 5.1 Cc1cccc(C)c1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C
CHEMBL234295 ccr1_mouse Mouse No 5.8 IC50 = 1770 nM Bind
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
599 11 2 9 2.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCOCC2)c(=O)c1=O
CHEMBL3099960 q9jly8_rat Rat No 5.8 IC50 = 1780 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
459 7 3 6 2.8 CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL232656 ccr1_human Human Yes 7.8 IC50 = 18 nM Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL2398758 ccr1_human Human No 7.8 IC50 = 18 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
419 5 1 3 4.1 CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CCN(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL232656 ccr1_human Human Yes 7.8 IC50 = 18 nM Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL231829 ccr1_human Human No 7.8 IC50 = 18 nM Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL2398761 ccr1_human Human No 7.8 IC50 = 18 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
442 5 2 3 4.2 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2322863 ccr1_human Human No 7.8 IC50 = 18 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
436 4 0 5 3.6 COc1cc(N2CCN(C(=O)Cn3cc(Cl)c(C(F)(F)F)n3)CC2)ccc1Cl
CHEMBL2180192 ccr1_human Human No 7.8 IC50 = 18 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
444 7 1 2 5.0 CC(C)[C@@H](NC(=O)CCc1ccccc1F)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2180195 ccr1_human Human No 7.8 IC50 = 18 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
455 5 1 4 5.1 CC(C)[C@@H](NC(=O)c1nc2ccccc2s1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2332942 ccr1_human Human No 7.8 IC50 = 18 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
411 6 3 6 2.5 CC(=O)Nc1ccc(O)cc1OC[C@@H](N)CN1CCC2(CC1)Cc1ccccc1O2
CHEMBL232837 ccr1_human Human No 7.8 IC50 = 18 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O
CHEMBL3679642 ccr1_human Human No 7.7 IC50 = 18.5 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
483 4 3 3 5.2 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679642 ccr1_human Human No 7.7 IC50 = 18.5 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
483 4 3 3 5.2 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)Nc2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679644 ccr1_human Human No 7.7 IC50 = 18.7 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
470 4 2 5 3.6 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2cncnc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679644 ccr1_human Human No 7.7 IC50 = 18.7 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
470 4 2 5 3.6 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2cncnc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL258359 ccr1_human Human No 6.8 IC50 = 180 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
502 4 1 4 4.8 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(Cl)c3)CC2)CC1
CHEMBL270433 ccr1_human Human No 6.8 IC50 = 180 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
458 7 2 4 4.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc2ccccc12
CHEMBL271903 ccr1_human Human No 6.8 IC50 = 180 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
512 4 1 4 4.2 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1
CHEMBL404033 ccr1_human Human No 6.8 IC50 = 180 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
448 4 1 4 3.8 Cc1ccccc1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL4577460 ccr1_human Human No 6.8 IC50 = 180 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
466 7 2 5 3.8 CC(C)NS(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1
CHEMBL2180521 ccr1_human Human No 6.8 IC50 = 180 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
427 6 2 2 4.6 CC(C)[C@@H](NC(=O)NCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2180548 ccr1_human Human No 6.8 IC50 = 180 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
414 5 2 3 3.6 CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL2398751 ccr1_human Human No 5.8 IC50 = 1800 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
476 5 2 3 4.9 CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL1184558 ccr1_human Human No 5.8 IC50 = 1800 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL356099 ccr1_human Human No 5.8 IC50 = 1800 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
434 7 1 1 6.4 C[N+]1(CCCC(c2ccccc2)c2ccccc2)CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL1183306 ccr1_human Human No 5.8 IC50 = 1800 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
443 4 1 1 6.7 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)c2c3ccccc3cc3ccccc23)CC1
CHEMBL289682 ccr1_human Human No 5.8 IC50 = 1800 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
443 4 1 1 6.7 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)c2c3ccccc3cc3ccccc23)CC1
CHEMBL2322891 ccr1_human Human No 6.7 IC50 = 182 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
464 3 0 4 4.0 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(Br)cc2)CC1
CHEMBL2180532 ccr1_human Human No 6.7 IC50 = 185 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
396 5 1 2 4.4 CC(C)C(NC(=O)c1ccccc1)C(=O)N1CC=C(c2ccc(Cl)cc2)CC1
CHEMBL411476 ccr1_human Human No 5.7 IC50 = 1850 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1
CHEMBL303947 ccr1_human Human No 4.7 IC50 = 18500 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
447 10 3 4 3.7 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccnc2ccccc12
CHEMBL4535696 ccr1_human Human No 5.7 IC50 = 1862.1 nM Funct
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1
CHEMBL3334726 ccr1_human Human No 7.7 IC50 = 19 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL387822 ccr1_human Human No 7.7 IC50 = 19 nM Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
544 11 2 8 3.0 COCCNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL4466500 ccr1_human Human No 7.7 IC50 = 19 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
439 6 1 7 2.7 CCS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1
CHEMBL2322857 ccr1_human Human No 7.7 IC50 = 19 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
416 4 0 5 3.2 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)cc3C)CC2)ccc1Cl
CHEMBL2180190 ccr1_human Human No 7.7 IC50 = 19 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
440 7 1 2 5.1 Cc1ccccc1CCC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C
CHEMBL258361 ccr1_human Human No 6.7 IC50 = 190 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F
CHEMBL198852 ccr1_human Human No 6.7 IC50 = 190 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1
CHEMBL4468514 ccr1_human Human No 5.7 IC50 = 1900 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
409 4 1 2 6.3 Cc1cc(-c2ccc(Cl)cc2)sc1C(=O)NCc1cccc(C(F)(F)F)c1
CHEMBL20921 ccr1_human Human Yes 5.7 IC50 = 1900 nM Bind
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
480 6 2 6 5.1 O=C(NC1CCN(CC1)Cc1ccc(c(c1)Cl)Cl)CSc1nc2c(s1)cc(cc2)N
CHEMBL272758 ccr1_human Human No 5.7 IC50 = 1900 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL142468 ccr1_human Human No 5.7 IC50 = 1900 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
476 7 1 4 5.5 COc1ccc(C(C#N)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1Br
CHEMBL33639 ccr1_mouse Mouse No 5.7 IC50 = 1900 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
498 4 1 3 7.1 O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21
CHEMBL2180545 ccr1_human Human No 6.7 IC50 = 191 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
448 6 1 2 5.8 CCCC(NC(=O)c1ccc2ccccc2c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2398721 ccr1_human Human No 6.7 IC50 = 194 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
449 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL4535696 ccr1_human Human No 5.7 IC50 = 1940 nM Funct
Antagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assayAntagonist activity at human TEV protease site linked CCR1 expressed in human U20S cell membranes co-expressing Gal4-VP16 transcription factor assessed as reduction in CCL3-induced G-protein activation preincubated for 30 mins in presence of CCL3 followed by incubation of 90 mins by [35S]GTPgammaS binding assay
347 3 1 3 4.3 CC(=O)C1=C(O)C(=O)N(c2ccc(Cl)c(C)c2)C1C1CCCCC1
CHEMBL2398753 ccr1_human Human No 6.7 IC50 = 196 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
475 5 2 3 4.9 CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@](N)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL427834 ccr1_human Human No 5.7 IC50 = 1980 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL4456123 ccr1_human Human Yes 8.7 IC50 = 2 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
451 5 1 7 2.8 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CC2)ccn1
CHEMBL3334817 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
437 6 3 3 3.9 CC[C@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL2332935 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
446 6 3 6 3.2 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL4444976 ccr1_human Human Yes 8.7 IC50 = 2 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
451 5 1 7 2.8 COc1cc(N2CCN(C(=O)Cn3nc(-c4ncc[nH]4)c4cccnc43)CC2)ccc1Cl
CHEMBL4474606 ccr1_human Human No 8.7 IC50 = 2 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
465 5 1 7 3.2 CS(=O)(=O)c1cc(C2(NC(=O)c3cncc4c3cnn4-c3ccc(F)cc3)CCC2)ccn1
CHEMBL4475173 ccr1_human Human No 8.7 IC50 = 2 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
439 6 2 6 2.4 CNS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cc1
CHEMBL2322853 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
464 4 0 5 4.3 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@@H](C)C2)ccc1Cl
CHEMBL3334725 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
449 5 3 3 4.1 CC(C)[C@@H](NC(=O)NC1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3334728 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3334817 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
437 6 3 3 3.9 CC[C@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL3334821 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
439 6 4 4 2.5 CC(C)[C@@H](NC(=O)NC[C@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3334822 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
424 6 3 4 2.7 CC(C)[C@@H](NC(=O)C[C@@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3334823 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
439 6 4 4 2.5 CC(C)[C@@H](NC(=O)NC[C@@H](C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3334825 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
452 7 3 4 3.5 CC(C)[C@@H](NC(=O)CCC(C)(C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL304358 ccr1_human Human No 8.7 IC50 = 2 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
448 11 3 5 3.3 CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O
CHEMBL1178613 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
459 5 1 2 6.3 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL34732 ccr1_human Human No 8.7 IC50 = 2 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
459 5 1 2 6.3 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL2398726 ccr1_human Human No 8.7 IC50 = 2.1 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3679637 ccr1_human Human No 8.7 IC50 = 2.1 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP1 cells after 12 hrs by scintillation proximity assay
468 4 2 3 4.8 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL3679637 ccr1_human Human No 8.7 IC50 = 2.1 nM Bind
Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).Scintillation Proximity Assay (SPA): CCR1 ligand binding using scintillation proximity assay (SPA).
468 4 2 3 4.8 CC1(C)CN(C(=O)[C@H]2CCCC[C@H]2NC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL2398724 ccr1_human Human No 8.7 IC50 = 2.2 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
449 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1N)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398748 ccr1_human Human No 8.7 IC50 = 2.2 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
448 5 2 3 4.5 CC(C)[C@@H](NC(=O)C1CCCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL4473668 ccr1_human Human No 8.7 IC50 = 2.2 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
510 6 2 7 3.4 CC(C)(CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1cccc(-n2cnnn2)c1
CHEMBL3099946 ccr1_human Human No 8.7 IC50 = 2.2 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
485 8 3 6 3.3 COc1ccc(NC(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(F)ccc2O3)c1
CHEMBL2398722 ccr1_human Human No 8.6 IC50 = 2.3 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398750 ccr1_human Human No 8.6 IC50 = 2.3 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
563 8 3 6 3.2 CC(C)[C@@H](NC(=O)C1CCCC1(O)CCN1CCOCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL232656 ccr1_human Human Yes 8.6 IC50 = 2.4 nM Funct
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL370162 ccr1_human Human No 8.6 IC50 = 2.4 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL2322875 ccr1_human Human No 8.6 IC50 = 2.5 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL23/CKbeta8.1-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL23/CKbeta8.1-induced chemotaxis
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2391800 ccr1_human Human No 8.6 IC50 = 2.5 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
504 6 2 6 2.9 O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1
CHEMBL2391938 ccr1_human Human No 8.6 IC50 = 2.5 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
486 8 2 6 3.5 COc1ccc(C(=O)NC2CC2)c(OC[C@@H](O)CN2CCC3(CC2)Cc2cc(Cl)ccc2O3)c1
CHEMBL2398747 ccr1_human Human No 8.6 IC50 = 2.5 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
434 5 2 3 4.1 CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL1178543 ccr1_human Human No 8.6 IC50 = 2.5 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
445 4 1 2 5.9 C[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL32257 ccr1_human Human No 8.6 IC50 = 2.5 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
445 4 1 2 5.9 C[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL2332936 ccr1_human Human No 8.6 IC50 = 2.6 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
430 6 3 6 2.7 CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL2398749 ccr1_human Human No 8.6 IC50 = 2.6 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
514 6 2 3 5.5 CC(C)[C@@H](NC(=O)CC12CC3CC(CC(C3)C1)C2)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398726 ccr1_human Human No 8.6 IC50 = 2.7 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MPIF-1-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MPIF-1-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2391937 ccr1_human Human No 8.6 IC50 = 2.8 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
456 7 2 5 3.4 O=C(NC1CC1)c1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL1178571 ccr1_human Human No 8.6 IC50 = 2.8 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
473 6 1 2 6.7 CCC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL33050 ccr1_human Human No 8.6 IC50 = 2.8 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
473 6 1 2 6.7 CCC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL1224189 ccr1_human Human No 8.5 IC50 = 2.9 nM Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
463 4 1 4 5.7 Cc1nnc([C@H]2CCCN2C(=O)Nc2ccc(C(F)(F)F)cc2)n1Cc1ccc(Cl)cc1
CHEMBL2398729 ccr1_human Human No 8.5 IC50 = 2.9 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398743 ccr1_human Human No 8.5 IC50 = 2.9 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
422 6 2 3 4.0 CC(C)CC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL2398763 ccr1_human Human No 8.5 IC50 = 2.9 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
476 5 3 4 4.1 CC(C)[C@@H](NC(=O)c1ccc(F)c(O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL199412 ccr1_human Human No 7.7 IC50 = 20 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL200629 ccr1_human Human No 7.7 IC50 = 20 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl
CHEMBL232441 q9jly8_rat Rat No 7.7 IC50 = 20 nM Bind
Binding affinity at rat CCR1Binding affinity at rat CCR1
486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O
CHEMBL2398723 ccr1_human Human No 7.7 IC50 = 20 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2322846 ccr1_human Human No 7.7 IC50 = 20 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
460 4 0 5 3.6 COc1cc(N2CCN(C(=O)Cn3nc(Br)c(Cl)c3C)CC2)ccc1Cl
CHEMBL1224119 ccr1_human Human No 7.7 IC50 = 20 nM Bind
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
450 4 1 5 4.8 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nnnn1Cc1ccc(Cl)cc1
CHEMBL2180504 ccr1_human Human No 7.7 IC50 = 20 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
404 6 1 2 4.8 CC(C)[C@@H](NC(=O)CC1CCCC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL3334724 ccr1_human Human No 7.7 IC50 = 20 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
457 5 3 3 4.6 CC(C)[C@@H](NC(=O)Nc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL232638 ccr1_human Human No 7.7 IC50 = 20 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O
CHEMBL302533 ccr1_human Human No 7.7 IC50 = 20 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
496 9 3 5 3.6 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1
CHEMBL380568 ccr1_human Human No 6.7 IC50 = 200 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2
CHEMBL390707 ccr1_human Human No 6.7 IC50 = 200 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
502 8 2 7 3.1 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)c(=O)c1=O
CHEMBL270253 ccr1_human Human No 6.7 IC50 = 200 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL34053 ccr1_human Human No 6.7 IC50 = 200 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
404 4 1 3 5.1 O=C(NC1CCN(CC2CCCCC2)CC1)C1c2ccccc2Oc2ccccc21
CHEMBL272758 ccr1_human Human No 5.7 IC50 = 2040 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
468 4 1 4 4.1 O=S(=O)(c1ccccc1Cl)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL2398759 ccr1_human Human No 6.7 IC50 = 208 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
502 5 2 3 5.4 CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)C2(CCCC2)C1
CHEMBL2398718 ccr1_human Human No 7.7 IC50 = 21 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
441 5 2 4 3.4 CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C2(CC2)C1
CHEMBL232638 q9jly8_rat Rat No 7.7 IC50 = 21 nM Bind
Binding affinity at rat CCR1Binding affinity at rat CCR1
530 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCO)c(=O)c1=O
CHEMBL277930 ccr1_mouse Mouse Yes 7.7 IC50 = 21 nM Funct
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL331897 ccr1_mouse Mouse Yes 7.7 IC50 = 21 nM Funct
inhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptorinhibitory activity against MIP-1 alpha- induced [Ca2+] response in U937 cells expressing mouse CCR1 receptor
527 5 1 2 7.6 CC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3cc(Cl)ccc3Oc3ccc(Cl)cc32)CC1
CHEMBL256889 ccr1_human Human No 6.7 IC50 = 210 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
426 7 2 4 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1
CHEMBL4591935 ccr1_human Human No 6.7 IC50 = 210 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
429 4 1 3 5.6 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)cc1
CHEMBL2322884 ccr1_human Human No 6.7 IC50 = 210 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
507 5 1 6 3.2 CNC(=O)c1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(OC)c1Cl
CHEMBL4571547 ccr1_human Human No 5.7 IC50 = 2100 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
403 5 1 5 3.2 Cc1c(C(=O)NCc2cccc(S(C)(=O)=O)c2)cnn1-c1ccc(Cl)cc1
CHEMBL1185795 ccr1_human Human No 5.7 IC50 = 2100 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
449 6 2 2 5.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C(O)(c2ccccc2)c2ccccc2)CC1
CHEMBL433232 ccr1_human Human No 5.7 IC50 = 2100 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
449 6 2 2 5.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C(O)(c2ccccc2)c2ccccc2)CC1
CHEMBL1178601 ccr1_mouse Mouse No 5.7 IC50 = 2100 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
447 4 1 2 6.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL34165 ccr1_mouse Mouse No 5.7 IC50 = 2100 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
447 4 1 2 6.0 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL3099949 q9jly8_rat Rat No 5.7 IC50 = 2110 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
431 6 3 5 3.0 NC(=O)Nc1ccccc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL1224120 ccr1_human Human No 7.7 IC50 = 22 nM Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1
CHEMBL514611 ccr1_human Human Yes 7.7 IC50 = 22 nM Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1
CHEMBL3334825 ccr1_human Human No 7.7 IC50 = 22 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
452 7 3 4 3.5 CC(C)[C@@H](NC(=O)CCC(C)(C)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL473532 ccr1_human Human No 7.7 IC50 = 22 nM Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
457 4 1 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F
CHEMBL514611 ccr1_human Human Yes 7.7 IC50 = 22 nM Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1
CHEMBL4448064 ccr1_human Human No 7.7 IC50 = 22 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(F)cc1
CHEMBL2180191 ccr1_human Human No 7.7 IC50 = 22 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
440 7 1 2 5.1 Cc1cccc(CCC(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)c1
CHEMBL304845 ccr1_human Human No 7.7 IC50 = 22 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
462 11 3 5 3.5 CNC(=O)[C@H](CCC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1
CHEMBL2322885 ccr1_human Human No 6.7 IC50 = 220 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
521 5 0 6 3.6 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C(=O)N(C)C)c1Cl
CHEMBL234276 ccr1_human Human No 6.7 IC50 = 220 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
522 8 2 8 3.5 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Cl)s3)C[C@H]2C)c(=O)c1=O
CHEMBL256272 ccr1_human Human No 6.7 IC50 = 220 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
526 4 1 4 4.6 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Br
CHEMBL302533 ccr1_human Human No 6.7 IC50 = 220 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
496 9 3 5 3.6 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCC(F)(F)CC1
CHEMBL258363 ccr1_human Human No 5.7 IC50 = 2200 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(C(F)(F)F)cc1
CHEMBL2398760 ccr1_human Human No 5.7 IC50 = 2240 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
428 6 2 3 4.7 CC(C)[C@H](CN1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)c1ccccc1
CHEMBL402327 ccr1_human Human No 5.7 IC50 = 2260 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
496 4 1 4 4.8 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL403665 ccr1_human Human No 5.7 IC50 = 2260 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
482 4 1 4 4.5 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2ccccc2Cl)CC1
CHEMBL68937 ccr1_human Human No 5.6 IC50 = 2280 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
453 10 3 4 4.5 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1
CHEMBL232837 ccr1_human Human No 7.6 IC50 = 23 nM Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
529 10 3 8 2.3 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN)c(=O)c1=O
CHEMBL430166 ccr1_human Human No 7.6 IC50 = 23 nM Bind
Binding Affinity at CCL3Binding Affinity at CCL3
484 7 1 5 3.4 C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CS(=O)(=O)O)[C@H](C)CN1Cc1ccc(F)cc1
CHEMBL2322856 ccr1_human Human No 7.6 IC50 = 23 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
464 4 0 5 4.3 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)C[C@@H]2C)ccc1Cl
CHEMBL473532 ccr1_human Human No 7.6 IC50 = 23 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
457 4 1 2 5.2 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1F
CHEMBL257452 ccr1_human Human No 6.6 IC50 = 230 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1
CHEMBL68937 ccr1_human Human No 5.6 IC50 = 2300 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
453 10 3 4 4.5 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1
CHEMBL197345 ccr1_mouse Mouse No 4.6 IC50 = 23000 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
443 5 1 3 4.6 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C[C@@H](C)N(Cc2ccc(F)cc2)C[C@@H]1C
CHEMBL68692 ccr1_human Human No 5.6 IC50 = 2320 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
520 11 2 5 4.5 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)N1CCCC1
CHEMBL2398731 ccr1_human Human No 6.6 IC50 = 233 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
521 6 3 5 2.9 CC(C)[C@@H](NC(=O)c1ccc(S(N)(=O)=O)cc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL232044 ccr1_human Human No 5.6 IC50 = 2340 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccccc3F)C[C@H]2C)c(=O)c1=O
CHEMBL387608 q9jly8_rat Rat No 7.6 IC50 = 24 nM Bind
Binding affinity at rat CCR1Binding affinity at rat CCR1
598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O
CHEMBL2180506 ccr1_human Human No 7.6 IC50 = 24 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
416 5 1 2 4.6 CC(C)[C@@H](NC(=O)c1cccc(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL257452 ccr1_human Human No 6.6 IC50 = 240 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1cccs1
CHEMBL33639 ccr1_human Human No 6.6 IC50 = 240 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
498 4 1 3 7.1 O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Cl)ccc2Oc2ccc(Cl)cc21
CHEMBL1178579 ccr1_mouse Mouse No 6.6 IC50 = 240 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
603 4 1 2 7.5 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL33223 ccr1_mouse Mouse No 6.6 IC50 = 240 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
603 4 1 2 7.5 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL126978 ccr1_human Human No 6.6 IC50 = 240 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
563 13 4 4 5.5 O=C(NCCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL4462565 ccr1_human Human Yes 5.6 IC50 = 2400 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
394 4 1 4 4.2 Cc1c(C(=O)NCc2cccc(C(F)(F)F)c2)nnn1-c1ccc(Cl)cc1
CHEMBL411476 ccr1_human Human No 5.6 IC50 = 2460 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)c(Cl)c1
CHEMBL67803 ccr1_human Human No 5.6 IC50 = 2490 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
447 10 3 4 3.7 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ncccc2c1
CHEMBL232253 ccr1_human Human No 7.6 IC50 = 25 nM Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL2398716 ccr1_human Human Yes 7.6 IC50 = 25 nM Bind
Antagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hrAntagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hr
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 7.6 IC50 = 25 nM Bind
Antagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hrAntagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hr
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL2180510 ccr1_human Human No 7.6 IC50 = 25 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 5 1 2 4.8 Cc1ccc(C(=O)N[C@@H](C(=O)N2CCC(c3ccc(Cl)cc3)CC2)C(C)C)cc1
CHEMBL232253 ccr1_human Human No 7.6 IC50 = 25 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
544 8 2 7 3.1 CNc1c(Nc2cc(Br)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL258065 ccr1_human Human No 6.6 IC50 = 250 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
476 7 2 4 4.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1C(F)(F)F
CHEMBL2391800 q9jly8_rat Rat No 5.6 IC50 = 2500 nM Bind
Antagonist activity at rat CCR1Antagonist activity at rat CCR1
504 6 2 6 2.9 O=C(c1ccc(F)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CC[C@H](O)C1
CHEMBL4445779 ccr1_human Human No 5.6 IC50 = 2500 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
413 4 1 3 5.1 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccccc1F
CHEMBL34166 ccr1_human Human Yes 5.6 IC50 = 2500 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
444 7 1 3 5.9 N#CC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL33580 ccr1_mouse Mouse No 5.6 IC50 = 2500 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
586 4 1 3 7.3 O=C(NC1CCN(C/C2=C/CCCCCC2)CC1)C1c2cc(Br)ccc2Oc2ccc(Br)cc21
CHEMBL2398752 ccr1_human Human No 4.6 IC50 = 25000 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
490 6 1 3 5.5 CO[C@]1(c2ccc(Cl)cc2)CCN(C(=O)[C@H](NC(=O)c2ccc(Cl)cc2)C(C)C)CC1(C)C
CHEMBL256449 ccr1_human Human No 5.6 IC50 = 2550 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
488 4 1 4 3.9 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3cc(F)c(F)c(F)c3)CC2)CC1
CHEMBL309338 ccr1_human Human No 5.6 IC50 = 2570 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
448 10 3 5 3.1 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnnc2ccccc12
CHEMBL2180540 ccr1_human Human No 6.6 IC50 = 259 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 4 1 2 4.9 CC(C)(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2180502 ccr1_human Human No 7.6 IC50 = 26 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
392 7 1 2 4.6 CC(C)CCC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C
CHEMBL231829 ccr1_human Human No 7.6 IC50 = 26 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL232654 ccr1_human Human No 7.6 IC50 = 26 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2ccncc2)c(=O)c1=O
CHEMBL69274 ccr1_human Human No 7.6 IC50 = 26 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
446 9 3 5 3.0 NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCCC1
CHEMBL4557554 ccr1_human Human No 6.6 IC50 = 260 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
463 4 1 3 6.3 O=C(NCc1cccc(C(F)(F)F)c1)c1cccc2c1cnn2-c1ccc(Cl)c(Cl)c1
CHEMBL232441 ccr1_mouse Mouse No 6.6 IC50 = 260 nM Bind
Binding affinity at mouse CCR1Binding affinity at mouse CCR1
486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O
CHEMBL282285 ccr1_human Human Yes 6.6 IC50 = 260 nM Bind
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
431 6 1 5 4.8 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)cc2)CC1
CHEMBL3138187 ccr1_human Human No 6.6 IC50 = 260 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
766 12 4 4 12.8 CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(O)c(C(=O)O)c5)c5cc(Cl)c(O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL3138134 ccr1_human Human No 6.6 IC50 = 260 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL3138376 ccr1_human Human No 6.6 IC50 = 260 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)c5cc(Cl)c(OCc6ccccc6C(=O)O)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL307535 ccr1_human Human No 5.6 IC50 = 2600 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
466 10 3 5 3.3 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cnc2ccccc2n1
CHEMBL1910159 ccr1_human Human No 6.6 IC50 = 261 nM Bind
Displacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assayDisplacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assay
427 7 2 6 2.6 Cc1noc(C)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL2180544 ccr1_human Human No 6.6 IC50 = 262 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
426 4 1 2 5.2 Cc1ccccc1C(=O)NC(C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)(C)C
CHEMBL2180517 ccr1_human Human No 6.6 IC50 = 265 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
414 5 1 3 4.9 CC(C)C(NC(=O)Oc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL305423 ccr1_human Human No 7.6 IC50 = 27 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
482 11 4 6 3.4 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO
CHEMBL402827 ccr1_human Human No 6.6 IC50 = 270 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL454942 ccr1_human Human No 6.6 IC50 = 270 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
419 5 1 2 5.0 CCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1
CHEMBL455162 ccr1_human Human No 6.6 IC50 = 270 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
405 4 1 2 4.6 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1
CHEMBL232042 ccr1_human Human No 6.6 IC50 = 270 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
560 8 2 7 3.6 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccc(Br)cc3)C[C@H]2C)c(=O)c1=O
CHEMBL1178571 ccr1_mouse Mouse No 6.6 IC50 = 270 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
473 6 1 2 6.7 CCC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL33050 ccr1_mouse Mouse No 6.6 IC50 = 270 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
473 6 1 2 6.7 CCC[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL1178590 ccr1_mouse Mouse No 6.6 IC50 = 270 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
475 6 1 2 6.8 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL33614 ccr1_mouse Mouse No 6.6 IC50 = 270 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
475 6 1 2 6.8 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL2322872 ccr1_human Human No 5.6 IC50 = 2700 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
416 4 0 5 3.2 COc1cccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c1
CHEMBL4441094 ccr1_human Human Yes 7.6 IC50 = 28 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
425 5 1 7 2.3 CS(=O)(=O)c1cc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)ccn1
CHEMBL4513370 ccr1_human Human No 7.6 IC50 = 28 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
425 4 1 3 5.5 Cc1c(C(=O)N[C@@H](C)c2cccc(C(F)(F)F)c2F)cnn1-c1ccc(Cl)cc1
CHEMBL198966 ccr1_human Human No 7.6 IC50 = 28 nM Funct
Antagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cellsAntagonistic activity at human CCR1 by inhibition of MIP-1alpha induced calcium mobilization in THP1 cells
443 4 1 4 4.5 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)oc12
CHEMBL2180528 ccr1_human Human No 7.6 IC50 = 28 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL304358 ccr1_human Human No 7.6 IC50 = 28 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
448 11 3 5 3.3 CC(C)CC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O
CHEMBL256271 ccr1_human Human No 6.6 IC50 = 280 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
482 4 1 4 4.5 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl
CHEMBL270863 ccr1_human Human No 6.6 IC50 = 280 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc(Cl)ccc1Cl
CHEMBL68551 ccr1_human Human No 6.6 IC50 = 280 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
468 10 3 5 3.1 NC(=O)[C@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1
CHEMBL2180546 ccr1_human Human No 5.6 IC50 = 2832 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
416 5 3 4 2.3 CC(O)C(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL2398757 ccr1_human Human No 7.5 IC50 = 29 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
427 5 1 3 4.5 CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@H](c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL517290 ccr1_human Human No 6.5 IC50 = 290 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
401 5 1 3 4.0 COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1
CHEMBL67757 ccr1_human Human No 5.5 IC50 = 2900 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
478 11 3 6 3.1 CNC(=O)[C@H](CC(C)C)C[C@H](O)[C@H](Cc1ccc(OC)cc1)NC(=O)c1cnc2ccccc2n1
CHEMBL232251 ccr1_human Human No 5.5 IC50 = 2910 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
500 8 2 7 3.0 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3cccc(F)c3)C[C@H]2C)c(=O)c1=O
CHEMBL2398732 ccr1_human Human No 5.5 IC50 = 2940 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
486 6 3 4 3.9 CC(C)[C@@H](NC(=O)c1ccccc1C(=O)O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL333422 ccr1_human Human Yes 6.5 IC50 = 295 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
613 12 3 3 7.1 O=C(NCCc1ccc(F)cc1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL462442 ccr1_human Human No 5.5 IC50 = 2950 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
439 4 1 2 5.0 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1cccc(C(F)(F)F)c1
CHEMBL3334725 ccr1_human Human No 8.5 IC50 = 3 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
449 5 3 3 4.1 CC(C)[C@@H](NC(=O)NC1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398716 ccr1_human Human Yes 8.5 IC50 = 3 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 8.5 IC50 = 3 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL4448761 ccr1_human Human No 8.5 IC50 = 3 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1cncc2c1cnn2-c1ccc(F)cc1
CHEMBL2398745 ccr1_human Human No 8.5 IC50 = 3 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
406 5 2 3 3.3 CC(C)[C@@H](NC(=O)C1CC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398767 ccr1_human Human No 8.5 IC50 = 3 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
521 6 3 5 2.9 CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398716 ccr1_human Human Yes 8.5 IC50 = 3 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 8.5 IC50 = 3 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334727 ccr1_human Human No 8.5 IC50 = 3 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3334815 ccr1_human Human No 8.5 IC50 = 3 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL3334816 ccr1_human Human No 8.5 IC50 = 3 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
437 6 3 3 3.9 CC[C@@H](C)NC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL2398722 ccr1_human Human No 8.5 IC50 = 3.1 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CCC[C@@H]1O)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL1185511 ccr1_human Human No 8.5 IC50 = 3.1 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
631 6 1 2 8.3 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL418589 ccr1_human Human No 8.5 IC50 = 3.1 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
631 6 1 2 8.3 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL2391794 ccr1_human Human No 8.5 IC50 = 3.2 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
430 6 3 6 2.1 CNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL2398716 ccr1_human Human Yes 8.5 IC50 = 3.2 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 mins
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 8.5 IC50 = 3.2 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 mins
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3099948 ccr1_human Human No 8.5 IC50 = 3.2 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
447 6 4 6 2.7 NC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL3099961 ccr1_human Human No 8.5 IC50 = 3.2 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
445 6 4 6 2.5 CNC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(F)ccc1O2
CHEMBL2398716 ccr1_human Human Yes 8.5 IC50 = 3.3 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 mins
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 8.5 IC50 = 3.3 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 mins
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL2398730 ccr1_human Human No 8.5 IC50 = 3.3 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
476 5 2 3 4.9 CC(C)[C@@H](NC(=O)c1ccc(Cl)cc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL1178581 ccr1_human Human No 8.5 IC50 = 3.3 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
617 5 1 2 7.9 CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL33340 ccr1_human Human No 8.5 IC50 = 3.3 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
617 5 1 2 7.9 CC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL2178569 ccr1_human Human No 8.5 IC50 = 3.4 nM Funct
Antagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assayAntagonist activity at CCR1 assessed as inhibition of CCL3-induced chemotaxis by cell based assay
518 5 2 5 5.6 CC1(C)CN(CC/C=C2/c3cc(C(=O)O)ccc3OCc3ncccc32)C[C@H](c2ccc(Cl)cc2)[C@H]1O
CHEMBL2398765 ccr1_human Human No 8.5 IC50 = 3.4 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
576 7 4 4 5.4 CC(C)[C@@H](NC(=O)c1cccc(-c2ccccc2NC(N)=O)c1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398769 ccr1_human Human No 8.5 IC50 = 3.5 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
457 6 2 4 3.6 CC(C)[C@@H](NC(=O)Cc1ccncc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398741 ccr1_human Human No 8.4 IC50 = 3.6 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
394 5 2 3 3.3 CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL1178590 ccr1_human Human No 8.4 IC50 = 3.6 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
475 6 1 2 6.8 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL33614 ccr1_human Human No 8.4 IC50 = 3.6 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
475 6 1 2 6.8 CCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL2398757 ccr1_human Human No 8.4 IC50 = 3.7 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
427 5 1 3 4.5 CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@H](c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2322875 ccr1_human Human No 8.4 IC50 = 3.9 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced chemotaxisAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced chemotaxis
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL1178579 ccr1_human Human No 8.4 IC50 = 3.9 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
603 4 1 2 7.5 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL33223 ccr1_human Human No 8.4 IC50 = 3.9 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
603 4 1 2 7.5 C[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3cc(Br)ccc3Oc3ccc(Br)cc32)CC1
CHEMBL255629 ccr1_human Human No 7.5 IC50 = 30 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1c(Cl)cccc1Cl
CHEMBL256404 ccr1_human Human No 7.5 IC50 = 30 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
422 7 2 4 3.3 Cc1ccccc1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL198949 ccr1_human Human Yes 7.5 IC50 = 30 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL199412 ccr1_human Human No 7.5 IC50 = 30 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL200242 ccr1_human Human No 7.5 IC50 = 30 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2
CHEMBL391302 ccr1_human Human No 7.5 IC50 = 30 nM Bind
Binding Affinity at CCL3Binding Affinity at CCL3
476 8 2 5 2.7 C[C@H]1CN(C(=O)COc2ccc(Cl)cc2C(=O)NCCN)[C@H](C)CN1Cc1ccc(F)cc1
CHEMBL2180528 ccr1_human Human No 7.5 IC50 = 30 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
398 5 1 2 4.5 CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2180496 ccr1_human Human No 7.5 IC50 = 30 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 6 1 2 4.4 CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL371248 ccr1_human Human No 6.5 IC50 = 300 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
441 5 1 3 4.3 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CC2CCC(C1)N2Cc1ccc(F)cc1
CHEMBL196860 ccr1_mouse Mouse No 6.5 IC50 = 300 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O
CHEMBL199412 ccr1_human Human No 6.5 IC50 = 300 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
446 5 1 4 4.1 CC(=O)Nc1cc2ncccc2cc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL270631 ccr1_human Human No 6.5 IC50 = 300 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
408 7 2 4 3.0 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1
CHEMBL200794 ccr1_mouse Mouse No 5.5 IC50 = 3000 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
442 4 2 3 4.3 CC(=O)Nc1cc(Cl)cc2cc(C(=O)N3CCN(Cc4ccc(F)cc4)C[C@H]3C)[nH]c12
CHEMBL370162 ccr1_mouse Mouse No 5.5 IC50 = 3000 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
432 6 2 4 3.6 CC(=O)Nc1cc(Cl)ccc1NCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL2322875 ccr1_mouse Mouse No 5.5 IC50 = 3000 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in mouse WEHI274.1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in mouse WEHI274.1 cells
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL142318 ccr1_human Human No 5.5 IC50 = 3000 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
472 5 1 4 6.0 N#CC1(CCCN2CCC(O)(c3ccc(F)cc3)CC2)c2ccccc2CSc2ccccc21
CHEMBL308243 ccr1_human Human No 4.5 IC50 = 30000 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
453 10 3 4 4.5 CNC(=O)[C@@H](CC(C)C)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)c1cnc2ccccc2c1
CHEMBL2180519 ccr1_human Human No 6.5 IC50 = 303 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
448 7 1 3 4.2 CC(C)C(NS(=O)(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2322888 ccr1_human Human Yes 6.5 IC50 = 307 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
404 3 0 4 3.4 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1
CHEMBL232656 ccr1_human Human Yes 7.5 IC50 = 31 nM Bind
Binding Affinity at CCL3Binding Affinity at CCL3
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL305423 ccr1_human Human No 7.5 IC50 = 31 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
482 11 4 6 3.4 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NO
CHEMBL124127 ccr1_human Human No 7.5 IC50 = 31 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
549 12 4 4 5.1 O=C(NCCCO)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL2322888 ccr1_human Human Yes 6.5 IC50 = 310 nM Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3/MIP-1alpha-induced calcium flux by FLIPR assay
404 3 0 4 3.4 Cc1c(Cl)c(C(F)(F)F)nn1CC(=O)N1CCN(c2ccc(F)cc2)CC1
CHEMBL333063 ccr1_human Human No 6.5 IC50 = 310 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
664 12 3 4 7.4 O=C(NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1)NC1CCN(Cc2ccccc2)CC1
CHEMBL2391811 ccr1_human Human No 7.5 IC50 = 32 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
502 6 2 7 2.7 O=C(c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2)N1CCOCC1
CHEMBL1224120 ccr1_human Human No 7.5 IC50 = 32 nM Bind
Displacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPADisplacement of [125I]-MIP1-alpha from human recombinant CCR1 expressed in HEK293 cells after 4 hrs by SPA
449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1ncnn1Cc1ccc(Cl)cc1
CHEMBL2180509 ccr1_human Human No 7.5 IC50 = 32 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 5 1 2 4.8 Cc1ccccc1C(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C
CHEMBL2180525 ccr1_human Human No 7.5 IC50 = 32 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
378 6 1 2 4.2 CC(C)CC(=O)N[C@@H](C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C
CHEMBL3099952 ccr1_human Human No 7.5 IC50 = 32 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
442 5 2 5 3.4 O=C1CCc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2N1
CHEMBL2332939 ccr1_human Human No 7.5 IC50 = 32 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrsDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cells after 1.5 hrs
425 7 2 6 2.8 COc1ccc(NC(C)=O)c(OC[C@@H](N)CN2CCC3(CC2)Cc2ccccc2O3)c1
CHEMBL198949 ccr1_human Human Yes 6.5 IC50 = 320 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
429 5 1 3 4.2 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL256271 ccr1_human Human No 6.5 IC50 = 320 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
482 4 1 4 4.5 CC1CC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN1S(=O)(=O)c1ccccc1Cl
CHEMBL143194 ccr1_human Human No 5.5 IC50 = 3200 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
407 7 1 4 4.8 N#CCC(C#N)(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1
CHEMBL2322893 ccr1_human Human No 4.5 IC50 = 32000 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
416 4 0 5 3.2 COc1ccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc1
CHEMBL2180550 ccr1_human Human No 6.5 IC50 = 324 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
428 6 2 3 4.0 CC(C)CC(NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL256887 ccr1_human Human No 6.5 IC50 = 330 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
548 4 1 4 4.5 O=S(=O)(c1c(F)cc(F)cc1Br)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL2323422 ccr1_human Human No 5.5 IC50 = 3300 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
400 3 0 4 3.5 Cc1cccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)c1
CHEMBL142925 ccr1_human Human No 5.5 IC50 = 3300 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
499 5 1 4 5.5 CN1C(=O)c2ccccc2C(C#N)(CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c2ccccc21
CHEMBL4454067 ccr1_human Human No 7.5 IC50 = 34 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
425 5 1 7 2.3 CS(=O)(=O)c1ccc(CNC(=O)c2cncc3c2cnn3-c2ccc(F)cc2)cn1
CHEMBL2180526 ccr1_human Human No 7.5 IC50 = 34 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
392 7 1 2 4.6 CC[C@@H](C)[C@@H](NC(=O)CC(C)C)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2322848 ccr1_human Human No 6.5 IC50 = 340 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
397 4 1 6 2.4 COc1cc(N2CCN(C(=O)Cn3nc(N)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2322866 ccr1_human Human No 5.5 IC50 = 3400 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
512 5 0 5 5.2 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3-c3ccccc3)CC2)ccc1Cl
CHEMBL2398719 ccr1_human Human No 6.5 IC50 = 341 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
449 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](N)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL69876 ccr1_human Human No 5.5 IC50 = 3460 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
462 9 3 6 2.3 NC(=O)C(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1
CHEMBL473531 ccr1_human Human No 7.5 IC50 = 35 nM Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
473 4 1 2 5.7 CN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(C(F)(F)F)cc1Cl
CHEMBL2180515 ccr1_human Human No 7.5 IC50 = 35 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
426 7 1 2 4.8 CC(C)C(NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL258360 ccr1_human Human No 6.5 IC50 = 350 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1Cl
CHEMBL4456839 ccr1_human Human No 6.5 IC50 = 350 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
406 4 1 2 5.7 Cc1cc(C(=O)NCc2cccc(C(F)(F)F)c2)c(C)n1-c1ccc(Cl)cc1
CHEMBL231830 ccr1_human Human No 6.5 IC50 = 350 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
482 8 2 7 2.8 CNc1c(Nc2cc(Cl)ccc2OCC(=O)N2CCN(Cc3ccccc3)C[C@H]2C)c(=O)c1=O
CHEMBL255338 ccr1_human Human No 6.5 IC50 = 350 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
490 8 2 5 4.7 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1-c1ccsc1
CHEMBL258361 ccr1_human Human No 6.5 IC50 = 350 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1OC(F)(F)F
CHEMBL1178543 ccr1_mouse Mouse No 6.5 IC50 = 350 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
445 4 1 2 5.9 C[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL32257 ccr1_mouse Mouse No 6.5 IC50 = 350 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
445 4 1 2 5.9 C[N+]1(C/C2=C/CCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL68368 ccr1_human Human No 5.5 IC50 = 3500 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
462 9 3 6 2.3 NC(=O)[C@@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C1CCOCC1
CHEMBL402327 ccr1_human Human No 5.5 IC50 = 3570 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
496 4 1 4 4.8 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(C)(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL2180542 ccr1_human Human No 7.4 IC50 = 36 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 5 1 2 4.8 Cc1ccccc1C(=O)NC(C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C
CHEMBL411477 ccr1_human Human No 6.4 IC50 = 360 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl
CHEMBL381446 ccr1_human Human No 6.4 IC50 = 360 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
431 6 1 3 4.1 CC(=O)Nc1cc(Cl)ccc1CCC(=O)N1CCN(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL257509 ccr1_human Human No 6.4 IC50 = 360 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
460 7 2 4 3.8 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1Cl
CHEMBL339752 ccr1_human Human No 6.4 IC50 = 360 nM Bind
Inhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cellsInhibitory activity against human Chemokine receptor type 1 expressed in chinese hamster ovary cells
602 12 3 4 6.2 O=C(NCCN1CCCCC1)NCC(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL21143 ccr1_human Human No 5.4 IC50 = 3600 nM Bind
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
509 8 1 6 5.9 CCOc1ccc2nc(SCC(=O)NC3CCN(Cc4ccc(Cl)c(Cl)c4)CC3)sc2c1
CHEMBL509457 ccr1_human Human No 5.4 IC50 = 3600 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
433 6 1 2 5.4 CCCN(Cc1ccc(Cl)cc1)C(=O)[C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1
CHEMBL258369 ccr1_human Human No 5.4 IC50 = 3600 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
536 4 1 4 5.4 O=S(=O)(c1ccc(Cl)c(Cl)c1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL258362 ccr1_human Human No 5.4 IC50 = 3650 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
492 8 2 5 3.9 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(OC(F)(F)F)cc1
CHEMBL2322892 ccr1_human Human No 5.4 IC50 = 3650 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
400 3 0 4 3.5 Cc1ccc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc1
CHEMBL2322852 ccr1_human Human No 7.4 IC50 = 37 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
464 4 0 5 4.3 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)[C@H](C)C2)ccc1Cl
CHEMBL3099953 ccr1_human Human No 7.4 IC50 = 37 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
440 5 2 5 3.4 O=c1ccc2cccc(OC[C@@H](O)CN3CCC4(CC3)Cc3cc(Cl)ccc3O4)c2[nH]1
CHEMBL404732 ccr1_human Human No 6.4 IC50 = 370 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1
CHEMBL2180547 ccr1_human Human No 6.4 IC50 = 370 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
398 4 2 3 3.5 C/C=C(/NC(=O)c1ccccc1)C(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL269956 ccr1_human Human No 6.4 IC50 = 370 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL1178588 ccr1_human Human No 6.4 IC50 = 370 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
523 6 1 2 7.6 O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21
CHEMBL33586 ccr1_human Human No 6.4 IC50 = 370 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to human CCR1 receptors.
523 6 1 2 7.6 O=C(NC1CC[N+](Cc2ccccc2)(CC2CCCCCCC2)CC1)C1c2ccccc2Oc2ccccc21
CHEMBL2180536 ccr1_human Human No 6.4 IC50 = 375 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
433 5 1 3 4.1 CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCN(c2ccc(Cl)c(Cl)c2)CC1
CHEMBL397910 ccr1_human Human No 7.4 IC50 = 38 nM Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O
CHEMBL234262 ccr1_human Human No 7.4 IC50 = 38 nM Bind
Binding Affinity at CCL3Binding Affinity at CCL3
448 7 1 4 3.6 C[C@H]1CN(C(=O)COc2ccc(Cl)cc2CC(=O)O)[C@H](C)CN1Cc1ccc(F)cc1
CHEMBL2180497 ccr1_human Human No 7.4 IC50 = 38 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
426 7 1 2 4.8 CC[C@@H](C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL256821 ccr1_human Human No 6.4 IC50 = 380 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cccc(Cl)c1
CHEMBL1178558 ccr1_mouse Mouse No 6.4 IC50 = 380 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
489 7 1 2 7.2 CCCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL32713 ccr1_mouse Mouse No 6.4 IC50 = 380 nM Bind
Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.Inhibitory activity against [125I]-MIP-1 alpha binding to mouse CCR1 receptors.
489 7 1 2 7.2 CCCC[N+]1(CC2CCCCCCC2)CCC(NC(=O)C2c3ccccc3Oc3ccccc32)CC1
CHEMBL270564 ccr1_human Human No 6.4 IC50 = 385 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
414 7 2 5 3.1 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccsc1
CHEMBL1910160 ccr1_human Human No 6.4 IC50 = 387 nM Bind
Displacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assayDisplacement of [125I]-MIP-1alpha 125I]-MCP1 from CCR1 expressed in CHO-K1 cells by scintillation proximity assay
463 9 2 3 4.3 O=C(NCCCCN1CCC(Oc2ccc(F)cc2)C1)NCc1ccc(Br)cc1
CHEMBL2180537 ccr1_human Human No 6.4 IC50 = 388 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
364 5 1 2 3.8 CC(C)C(=O)NC(C(=O)N1CCC(c2ccc(Cl)cc2)CC1)C(C)C
CHEMBL272559 ccr1_human Human No 5.4 IC50 = 3880 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
438 8 2 5 3.0 COc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1
CHEMBL387608 ccr1_human Human No 7.4 IC50 = 39 nM Funct
Antagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxisAntagonist activity against human CCR1 receptor expressed in THP1 cells assessed as inhibition of chemotaxis
598 11 3 9 2.2 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCCN2CCNCC2)c(=O)c1=O
CHEMBL1628706 ccr1_human Human Yes 7.4 IC50 = 39 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
482 11 4 6 2.5 O[C@H]([C@@H](NC(=O)c1cnc2c(n1)cccc2)Cc1cccc(c1)F)C[C@H](C(=O)N)CCC(O)(C)C
CHEMBL402827 ccr1_human Human No 6.4 IC50 = 390 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL1224188 ccr1_human Human No 8.4 IC50 = 4 nM Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrsAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL3-induced chemotaxis after 3 hrs
449 4 1 4 5.4 O=C(Nc1ccc(C(F)(F)F)cc1)N1CCC[C@@H]1c1nncn1Cc1ccc(Cl)cc1
CHEMBL4444976 ccr1_human Human Yes 8.4 IC50 = 4 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay
451 5 1 7 2.8 COc1cc(N2CCN(C(=O)Cn3nc(-c4ncc[nH]4)c4cccnc43)CC2)ccc1Cl
CHEMBL3334728 ccr1_human Human No 8.4 IC50 = 4 nM Bind
Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 minsAntagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins
465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398726 ccr1_human Human No 8.4 IC50 = 4 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of HCC-1-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of HCC-1-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL232441 ccr1_human Human No 8.4 IC50 = 4 nM Funct
Antagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPRAntagonist activity at human CCR1 expressed in THP1 cells assessed as effect on MIP-1-alpha-induced calcium flux by FLIPR
486 7 2 7 2.5 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(N)c(=O)c1=O
CHEMBL200629 ccr1_human Human No 8.4 IC50 = 4 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
459 6 1 4 4.2 COc1cc(/C=C/C(=O)N2CCN(Cc3ccc(F)cc3)C[C@H]2C)c(NC(C)=O)cc1Cl
CHEMBL372807 ccr1_mouse Mouse No 8.4 IC50 = 4 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
471 6 1 4 4.3 COc1cc(/C=C/C(=O)N2C3CCC2CN(Cc2ccc(F)cc2)C3)c(NC(C)=O)cc1Cl
CHEMBL2322875 ccr1_human Human No 8.4 IC50 = 4 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL3334726 ccr1_human Human No 8.4 IC50 = 4 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
465 5 4 4 3.0 CC(C)[C@@H](NC(=O)N[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398737 ccr1_human Human No 8.4 IC50 = 4.1 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
456 6 2 3 4.2 CC(C)[C@@H](NC(=O)Cc1ccccc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398758 ccr1_human Human No 8.4 IC50 = 4.1 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
419 5 1 3 4.1 CC(C)[C@@H](NC(=O)C1CCCC1)C(=O)N1CCN(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398716 ccr1_human Human Yes 8.4 IC50 = 4.2 nM Bind
Displacement of [125I]hMIP-1alpha from CCR1 in human PBMCDisplacement of [125I]hMIP-1alpha from CCR1 in human PBMC
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 8.4 IC50 = 4.2 nM Bind
Displacement of [125I]hMIP-1alpha from CCR1 in human PBMCDisplacement of [125I]hMIP-1alpha from CCR1 in human PBMC
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL2398735 ccr1_human Human No 8.4 IC50 = 4.3 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
443 5 2 4 3.6 CC(C)[C@@H](NC(=O)c1cccnc1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2398742 ccr1_human Human No 8.4 IC50 = 4.4 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
408 5 2 3 3.6 CC(C)C(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL2398726 ccr1_human Human No 8.4 IC50 = 4.4 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of ieukotactin-1-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of ieukotactin-1-induced chemotaxis
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL4475237 ccr1_human Human No 8.4 IC50 = 4.5 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
438 6 2 5 3.0 CNS(=O)(=O)c1ccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)cc1
CHEMBL2398741 ccr1_human Human No 8.4 IC50 = 4.5 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
394 5 2 3 3.3 CCC(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL3099941 ccr1_human Human No 8.4 IC50 = 4.5 nM Bind
Displacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysisDisplacement of [125I]MIP-1alpha from human recombinant CCR1 expressed in HEK293 cell membranes after 1.5 hrs by microbeta counting analysis
475 7 3 6 3.3 CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL2398742 ccr1_human Human No 8.3 IC50 = 4.6 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
408 5 2 3 3.6 CC(C)C(=O)N[C@@H](C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)C(C)C
CHEMBL2398770 ccr1_human Human No 8.3 IC50 = 4.7 nM Bind
Antagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxisAntagonist activity at human CCR1 assessed as inhibition of MIP1alpha-induced chemotaxis
476 5 2 3 4.9 CC(C)[C@@H](NC(=O)c1ccccc1Cl)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2322875 ccr1_human Human No 8.3 IC50 = 4.8 nM Funct
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of CCL15/Leukotactin1-induced calcium flux by FLIPR assay
450 4 0 5 3.9 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)ccc1Cl
CHEMBL269957 ccr1_human Human No 7.4 IC50 = 40 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
442 7 2 4 3.6 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccccc1Cl
CHEMBL429419 ccr1_human Human No 7.4 IC50 = 40 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
456 7 2 4 4.0 Cc1cccc(Cl)c1S(=O)(=O)NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1
CHEMBL232656 ccr1_human Human Yes 7.4 IC50 = 40 nM Funct
Antagonistic activity at human CCR1 in CHO-K1 cellsAntagonistic activity at human CCR1 in CHO-K1 cells
434 6 2 4 3.1 NC(=O)Nc1cc(Cl)ccc1OCC(=O)N1CCN(C[C@H]1C)Cc1ccc(cc1)F
CHEMBL200242 ccr1_mouse Mouse No 7.4 IC50 = 40 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2
CHEMBL196860 ccr1_human Human No 7.4 IC50 = 40 nM Funct
Antagonistic activity at rat CCR1 in CHO-K1 cellsAntagonistic activity at rat CCR1 in CHO-K1 cells
430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O
CHEMBL2398766 ccr1_human Human No 7.4 IC50 = 40 nM Bind
Binding affinity to human CCR1Binding affinity to human CCR1
477 6 2 4 3.1 CC(C)[C@@H](NC(=O)c1cccc(S(N)(=O)=O)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2322843 ccr1_human Human No 7.4 IC50 = 40 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
396 4 0 5 3.2 COc1cc(N2CCN(C(=O)Cn3nc(C)c(Cl)c3C)CC2)ccc1Cl
CHEMBL2180499 ccr1_human Human No 7.4 IC50 = 40 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
426 7 1 2 4.8 CC(C)[C@@H](NC(=O)CCc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2180514 ccr1_human Human No 7.4 IC50 = 40 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 6 1 2 4.4 CC(C)C(NC(=O)Cc1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2391936 ccr1_human Human No 6.4 IC50 = 400 nM Bind
Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assayAntagonist activity at CCR1 in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 2 hrs by fluorescence assay
475 8 4 7 1.9 NCCNC(=O)c1ccc(O)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL404465 ccr1_human Human No 6.4 IC50 = 400 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
482 4 1 4 4.5 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL357919 ccr1_human Human Yes 6.4 IC50 = 400 nM Funct
Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorInhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptor
430 6 1 3 5.5 N#CC(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
CHEMBL460535 ccr1_human Human No 5.4 IC50 = 4000 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
419 4 1 2 5.0 Cc1cc(CN(C)C(=O)[C@H]2CCCN2C(=O)Nc2ccc(Cl)cc2)ccc1Cl
CHEMBL3138115 ccr1_human Human No 5.4 IC50 = 4000 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL3138540 ccr1_human Human No 5.4 IC50 = 4000 nM Funct
Inhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectantsInhibition of RANTES-induced migration of human embryonic kidney (CCR1/HEK) cell transfectants
None None None CC(C)CCCC(C)[C@H]1CC[C@H]2[C@@H]3CCC4C[C@@H](CCC=C(c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)c5cc(Cl)c(OCc6cccc(B(O)O)c6)c(C(=O)O)c5)CC[C@]4(C)[C@H]3CC[C@@]21C
CHEMBL4472994 ccr1_human Human No 7.4 IC50 = 41 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
451 6 1 7 2.8 O=C(NCc1ccnc(S(=O)(=O)C2CC2)c1)c1cncc2c1cnn2-c1ccc(F)cc1
CHEMBL200242 ccr1_human Human No 7.4 IC50 = 41 nM Funct
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
484 7 1 4 3.9 CN(C)CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1C2CCC1CN(Cc1ccc(F)cc1)C2
CHEMBL4444092 ccr1_human Human No 7.4 IC50 = 41.6 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
414 5 2 3 3.6 CC1(C)CN(C(=O)CCNC(=O)c2ccccc2)CC[C@]1(O)c1ccc(Cl)cc1
CHEMBL411477 ccr1_human Human No 6.4 IC50 = 410 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
476 7 2 4 4.3 O=S(=O)(NCCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(Cl)cc1Cl
CHEMBL2398716 ccr1_human Human Yes 7.4 IC50 = 42 nM Bind
Antagonist activity at CCR1 receptor in human whole blood assessed as blocked of LKN1-mediated CD11b upregulation preincubated for 1 hrAntagonist activity at CCR1 receptor in human whole blood assessed as blocked of LKN1-mediated CD11b upregulation preincubated for 1 hr
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL3334824 ccr1_human Human Yes 7.4 IC50 = 42 nM Bind
Antagonist activity at CCR1 receptor in human whole blood assessed as blocked of LKN1-mediated CD11b upregulation preincubated for 1 hrAntagonist activity at CCR1 receptor in human whole blood assessed as blocked of LKN1-mediated CD11b upregulation preincubated for 1 hr
438 6 3 4 3.1 O=C(CC(O)(C)C)N[C@@H](C(=O)N1CC[C@](C(C1)(C)C)(O)c1ccc(cc1)Cl)C(C)C
CHEMBL4443458 ccr1_human Human No 7.4 IC50 = 42 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
420 5 2 3 3.7 CC(CNC(=O)C1CCCC1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL397910 ccr1_human Human No 7.4 IC50 = 42 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 expressed in THP1 cells
577 10 2 8 3.9 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc1ccc(Cl)cc1Nc1c(NCc2cccnc2)c(=O)c1=O
CHEMBL270254 ccr1_human Human No 6.4 IC50 = 420 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
502 4 1 4 4.8 O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL4574870 ccr1_human Human No 6.4 IC50 = 420 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
418 6 2 5 2.7 CNS(=O)(=O)c1ccc(CNC(=O)c2cnn(-c3ccc(Cl)cc3)c2C)cc1
CHEMBL2322882 ccr1_human Human No 6.4 IC50 = 420 nM Bind
Displacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]-CCL3/MIP-1alpha from CCR1 in human THP1 cells
494 5 1 6 3.6 COc1cc(N2CCN(C(=O)Cn3nc(C(F)(F)F)c(Cl)c3C)CC2)cc(C(=O)O)c1Cl
CHEMBL270254 ccr1_human Human No 6.4 IC50 = 420 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
502 4 1 4 4.8 O=S(=O)(c1c(Cl)cccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL69816 ccr1_human Human No 6.4 IC50 = 420 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
462 12 3 5 3.7 CC(C)CCC[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(N)=O
CHEMBL21199 ccr1_human Human No 5.4 IC50 = 4200 nM Bind
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
411 7 1 5 4.4 O=C(CSc1nc2ccccc2s1)NCC1CCCN(Cc2ccccc2)C1
CHEMBL257853 ccr1_human Human No 5.4 IC50 = 4200 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
516 4 1 4 5.2 CC1(N2CCC(O)(c3ccc(Cl)cc3)CC2)CCN(S(=O)(=O)c2c(Cl)cccc2Cl)CC1
CHEMBL420924 ccr1_human Human No 5.4 IC50 = 4200 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
414 10 3 5 2.9 CC[C@H](C)[C@H](NC(=O)c1cnc2ccccc2n1)[C@@H](O)C[C@@H](CC(C)C)C(=O)NC
CHEMBL2180533 ccr1_human Human No 6.4 IC50 = 423 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
382 5 1 2 4.0 CC(C)C(NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(F)cc2)CC1
CHEMBL4546558 ccr1_human Human No 7.4 IC50 = 43.9 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
477 6 3 4 3.0 CC(=O)N[C@@H]1CC[C@@H](C(=O)N[C@H](C)CC(=O)N2CC[C@](O)(c3ccc(Cl)cc3)C(C)(C)C2)C1
CHEMBL269956 ccr1_human Human No 6.4 IC50 = 430 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assayAntagonist activity at human CCR1 receptor expressed in THP1 cells assessed as human MIP-1-alpha-stimulated intracellular calcium level by FLIPR assay
482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC(N2CCC(O)(c3ccc(Cl)cc3)CC2)CC1
CHEMBL258064 ccr1_human Human No 6.4 IC50 = 430 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
422 7 2 4 3.3 Cc1ccc(S(=O)(=O)NCCCN2CCC(O)(c3ccc(Cl)cc3)CC2)cc1
CHEMBL404757 ccr1_human Human No 6.4 IC50 = 430 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
486 4 1 4 4.3 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Cl)c(F)c3)CC2)CC1
CHEMBL409498 ccr1_human Human No 6.4 IC50 = 430 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
482 4 1 4 4.4 Cc1cccc(Cl)c1S(=O)(=O)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL462650 ccr1_human Human No 4.4 IC50 = 43000 nM Bind
Displacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cellsDisplacement of [125I]MIP-1-alpha from human recombinant CCR1 expressed in HEK293 cells
435 6 2 3 4.0 O=C([C@H]1CCCN1C(=O)Nc1ccc(Cl)cc1)N(CCO)Cc1ccccc1Cl
CHEMBL4464625 ccr1_mouse Mouse No 7.4 IC50 = 44 nM Funct
Antagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
453 6 1 7 3.2 CC[C@H](NC(=O)c1cncc2c1cnn2-c1ccc(F)cc1)c1ccnc(S(C)(=O)=O)c1
CHEMBL4565496 ccr1_human Human No 7.4 IC50 = 44 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
452 6 1 5 3.3 CN(C)S(=O)(=O)c1cccc(CNC(=O)c2cccc3c2cnn3-c2ccc(F)cc2)c1
CHEMBL391239 ccr1_human Human No 7.4 IC50 = 44 nM Bind
Binding Affinity at CCL3Binding Affinity at CCL3
541 9 1 7 2.5 COS(=O)(=O)NC(=O)Cc1cc(Cl)ccc1OCC(=O)N1C[C@H](C)N(Cc2ccc(F)cc2)C[C@H]1C
CHEMBL2180187 ccr1_human Human No 7.4 IC50 = 44 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
430 6 1 2 4.6 CC(C)[C@@H](NC(=O)Cc1cccc(F)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL517290 ccr1_human Human No 6.4 IC50 = 440 nM Funct
Antagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrsAntagonist activity at human CCR1 in THP1 cells assessed as inhibition of MIP-1-alpha-induced chemotaxis after 3 hrs
401 5 1 3 4.0 COc1ccc(NC(=O)N2CCC[C@@H]2C(=O)N(C)Cc2ccc(Cl)cc2)cc1
CHEMBL271903 ccr1_human Human No 6.4 IC50 = 440 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
512 4 1 4 4.2 O=S(=O)(c1ccccc1Cl)N1CCC(N2CCC(O)(c3ccc(Br)cc3)CC2)CC1
CHEMBL65784 ccr1_human Human No 6.4 IC50 = 440 nM Funct
Inhibition of CCL3 induced chemotaxis in human T lymphocytesInhibition of CCL3 induced chemotaxis in human T lymphocytes
556 13 3 5 5.2 CC(C)(F)CCC(C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1)C(=O)NCc1ccccc1
CHEMBL3099941 q9jly8_rat Rat No 6.4 IC50 = 447 nM Bind
Displacement of [125I]MIP-1alpha from rat CCR1Displacement of [125I]MIP-1alpha from rat CCR1
475 7 3 6 3.3 CNC(=O)Nc1ccc(OC)cc1OC[C@@H](O)CN1CCC2(CC1)Cc1cc(Cl)ccc1O2
CHEMBL198852 ccr1_mouse Mouse No 6.4 IC50 = 448 nM Funct
Antagonistic activity at mouse CCR1 in CHO-K1 cellsAntagonistic activity at mouse CCR1 in CHO-K1 cells
415 5 1 3 3.8 CC(=O)Nc1cc(Cl)ccc1/C=C/C(=O)N1CCN(Cc2ccc(F)cc2)CC1
CHEMBL302038 ccr1_human Human No 4.4 IC50 = 44800 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
516 9 3 5 4.7 CC1(C)CC([C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)c2cnc3ccccc3n2)C(N)=O)CC(C)(C)C1
CHEMBL2177135 ccr1_human Human No 7.4 IC50 = 45 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
446 6 1 2 5.1 CC(C)[C@@H](NC(=O)Cc1cccc(Cl)c1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL2180493 ccr1_human Human No 7.4 IC50 = 45 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
412 6 1 2 4.9 CC[C@@H](C)[C@@H](NC(=O)c1ccccc1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL196860 ccr1_human Human No 7.4 IC50 = 45 nM Funct
Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1Inhibitory effect on transwell chemotaxis induced by 1 nM MIP-1alpha in mouse pre-B cells transfected with human CCR1
430 5 2 3 3.7 C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)/C=C/c1ccc(Cl)cc1NC(N)=O
CHEMBL4593102 ccr1_human Human No 7.3 IC50 = 45.3 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
433 5 2 4 3.6 CC(C)(CC(=O)N1CCC(O)(c2ccc(C#N)cc2)C(C)(C)C1)NC(=O)c1ccccc1
CHEMBL4445316 ccr1_human Human No 6.4 IC50 = 450 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
414 4 1 4 4.5 O=C(NCc1cccc(C(F)(F)F)c1)c1nccc2c1cnn2-c1ccc(F)cc1
CHEMBL4568987 ccr1_human Human No 6.4 IC50 = 450 nM Funct
Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assayAntagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay
379 4 1 3 4.7 O=C(NCc1cccc(Cl)c1)c1cccc2c1cnn2-c1ccc(F)cc1
CHEMBL20532 ccr1_human Human No 6.4 IC50 = 450 nM Bind
Binding affinity to CCR1Binding affinity to CCR1
465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1
CHEMBL20532 ccr1_human Human No 6.4 IC50 = 450 nM Bind
Concentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cellsConcentration required for 50% inhibition of [125I]eotaxin binding to human CCR1 receptor expressed in CHO cells
465 6 1 5 5.5 O=C(CSc1nc2ccccc2s1)NC1CCN(Cc2ccc(Cl)c(Cl)c2)CC1
CHEMBL2398726 ccr1_human Human No 7.3 IC50 = 46 nM Bind
Antagonist activity at CCR1 in whole blood (unknown origin) assessed as inhibition of MIP1alpha-induced upregulation of beta2-integrin CD11bAntagonist activity at CCR1 in whole blood (unknown origin) assessed as inhibition of MIP1alpha-induced upregulation of beta2-integrin CD11b
450 5 3 4 3.1 CC(C)[C@@H](NC(=O)[C@@H]1CC[C@@H](O)C1)C(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1
CHEMBL2180503 ccr1_human Human No 7.3 IC50 = 46 nM Bind
Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cellsDisplacement of [125I]MIP-1alpha from CCR1 in human THP1 cells
376 6 1 2 4.0 CC(C)[C@@H](NC(=O)CC1CC1)C(=O)N1CCC(c2ccc(Cl)cc2)CC1
CHEMBL308473 ccr1_human Human No 7.3 IC50 = 46 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
482 11 4 6 2.5 CC(C)(O)CCC(C[C@H](O)[C@H](Cc1cccc(F)c1)NC(=O)c1cnc2ccccc2n1)C(N)=O
CHEMBL4592423 ccr1_human Human No 7.3 IC50 = 46.7 nM Bind
Displacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assayDisplacement of [125I]-MIP-1alpha from CCR1 in human THP-1 cells after 12 h by scintillation proximity assay
535 6 3 5 4.4 C[C@H](CC(=O)N1CC[C@](O)(c2ccc(Cl)cc2)C(C)(C)C1)NC(=O)[C@@H]1CC[C@@H](NC(=O)OC(C)(C)C)C1
CHEMBL255797 ccr1_human Human No 6.3 IC50 = 460 nM Bind
Displacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cellsDisplacement of [125I]MIP1-alpha from human CCR1 receptor expressed in THP1 cells
512 4 1 4 4.2 O=S(=O)(c1ccccc1Br)N1CCC[C@H](N2CCC(O)(c3ccc(Cl)cc3)CC2)C1
CHEMBL69735 ccr1_human Human No 5.3 IC50 = 4600 nM Bind
Inhibition of CCL3 binding to C-C chemokine receptor type 1Inhibition of CCL3 binding to C-C chemokine receptor type 1
422 10 4 6 1.2 NC(=O)[C@H](CCO)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cnc2ccccc2n1
CHEMBL257853 ccr1_human Human No 5.3 IC50 = 4650 nM Funct
Antagonist activity at human CCR1 receptor expressed in THP1